CN108209934B - Auditory sensitivity detection system based on stimulation frequency otoacoustic emission - Google Patents
Auditory sensitivity detection system based on stimulation frequency otoacoustic emission Download PDFInfo
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Abstract
The invention relates to an auditory sensitivity detection system based on the otoacoustic emission of stimulation frequency, which comprises a sound card, an acoustic sensor, a computer and a signal feedback device, wherein the sound card is used for receiving a sound signal; the test execution system comprises an intensity sensitivity detection module based on SFOAEs and a frequency sensitivity detection module based on SFOAEs, and the intensity sensitivity detection module based on SFOAEs is used for determining the hearing intensity threshold corresponding to the corresponding frequency point by detecting the stimulus frequency otoacoustic emission detection data of each frequency point; the SFOAEs-based frequency sensitivity detection module is used for extracting the otoacoustic emission suppression tuning curve of the stimulation frequency at a specified frequency point and determining the frequency sensitivity at the specified frequency point.
Description
Technical Field
The invention relates to an auditory sense detection system, in particular to an auditory sense detection system for carrying out objective, quantitative and comprehensive detection on the intensity sensitivity and frequency sensitivity of an auditory system based on stimulation frequency otoacoustic emission.
Background
Otoacoustic Emissions (OAEs) are a weak audio energy generated in the cochlea of the inner ear, conducted through the ossicular chain and tympanic membrane, and released into the external auditory canal, and are part of the normal function of the human ear. This phenomenon was first discovered in 1978 by David Kemp, a scholarly in the united kingdom and applied clinically. The discovery of otoacoustic emission proves that the cochlea, as a peripheral auditory receptor, not only can passively convert external acoustic signals into bioelectric signals and transmit the bioelectric signals to the center to cause auditory sensation, but also has an active energy release process, thereby establishing the theory that the cochlea is a bidirectional transducer. Because the existence of OAE becomes an objective index for evaluating whether the functions of the auditory peripheral system are intact or not, a brand-new concept and research direction are provided for auditory physiology research, and the discovery of OAE becomes one of important breakthroughs of modern auditory physiology. The otoacoustic Emissions can be classified into two major categories, i.e., Spontaneous otoacoustic Emissions (SOAEs) and evoked otoacoustic Emissions (EOAEs), according to the presence or absence of external stimulus sounds. EOAEs can be divided into Transient-induced Otoacoustic Emissions (TEOAEs), Distortion-Product Otoacoustic Emissions (DPOAEs), and Stimulus-Frequency Otoacoustic Emissions (SFOAEs) according to the difference of the induced Stimulus sound.
Currently, the subjective behavioral response audiometry method is clinically used for the hearing threshold intensity test, for example: pure tone audiometry, which requires subjective cooperation, cannot perform objective tests on infants. The clinically adopted tests of transient evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) can only carry out qualitative screening, give a screening result of whether the peripheral function of the auditory sense is normal or not, and lack a quantitative detection result of the intensity sensitivity (hearing threshold). Therefore, a quantitative, objective and comprehensive detection method for the intensity sensitivity of the auditory system is lacking clinically at present. In addition, there is no objective, quantitative, comprehensive detection method for the frequency sensitivity of the auditory system in clinic.
The stimulating frequency otoacoustic emissions (SFOAEs) are the active emission of a weak acoustic signal with the same stimulating acoustic frequency after the cochlea of the inner ear is stimulated by a signal with a single frequency. Since it can reflect the active mechanism of the outer hair cells of the cochlea, it further reflects the function of the auditory peripheral system. Thus, stimulating frequency otoacoustic emissions has the potential to objectively, quantitatively, non-invasively detect auditory system function. The frequency of the stimulus frequency otoacoustic emissions is referred to as stimulus frequency otoacoustic emissions since the frequency of the stimulus frequency otoacoustic emissions is identical to the frequency of the stimulus sound. The intensity of the otoacoustic emissions at the stimulation frequency is very low, typically between-15 dB SPL and +20dB SPL. Its frequency sensitivity at a characteristic frequency can be characterized by the Q value of the tuning characteristic represented by the otoacoustic emission suppression tuning curve at the stimulation frequency. SFOAEs under pure tone stimulation are pure tones of the same frequency as the stimulating sound, so the intensity of SFOAEs has the potential to objectively and quantitatively reflect the hearing threshold at a certain frequency. The SFOAEs signals and the stimulus sound signals are completely aliased in the frequency domain; also, most of the time, the SFOAEs signals are aliased with the stimulation artifacts in the time domain. In addition, the strength of SFOAEs signals is also extremely small relative to the strength of the stimulus sound, typically about 30dBSPL or more below the strength of the stimulus sound. Therefore, using SFOAEs signals to quantitatively and objectively reflect the threshold of hearing intensity requires more sophisticated detection techniques to suppress the stimulus artifacts.
In the prior art, patent application No. 200910237175.3 entitled "a portable full-function otoacoustic emission detection system" discloses a portable otoacoustic emission detection system based on a USB multimedia sound card, and realizes full-function quantitative detection and analysis of transient-induced otoacoustic emission (TEOAEs) and distorted otoacoustic emission (DPOAEs) signals on a VC + + Studio 2005-based software platform. However, this patent does not relate to the detection of the otoacoustic emissions at the stimulation frequency and to the technique and method for the objective quantitative detection of the intensity threshold of the auditory system using SFOAEs, and, at the same time, to the technique and method for the quantitative detection of the frequency sensitivity of the auditory system using SFOAE STCs; further, patent application No. 201210333260.1 entitled "a stimulus frequency otoacoustic emission tuning curve detection and calibration system" discloses only a detection method of a stimulus frequency otoacoustic emission tuning curve and a detection technique of a calibration system, but does not relate to a technique and a method for objective and quantitative detection of an intensity hearing threshold of an auditory system using stimulus frequency otoacoustic emission, nor does it relate to a detailed technique and a method for quantitative detection of frequency sensitivity of an auditory system using SFOAE STCs.
Disclosure of Invention
In view of the above problems, the present invention provides an auditory sensitivity detection system based on the otoacoustic emission of stimulation frequency, which can not only realize quantitative and objective detection of intensity resolution sensitivity at different frequencies through the test of the otoacoustic emission of stimulation frequency; and the quantitative and objective detection of the frequency resolution sensitivity at different frequencies can be completed by testing the otoacoustic emission inhibition tuning curve of the stimulation frequency.
In order to achieve the purpose, the invention adopts the following technical scheme: an auditory sensitivity detection system based on the otoacoustic emission at a stimulation frequency, which is characterized by comprising a sound card, an acoustic sensor and a computer, wherein the acoustic sensor comprises a micro-speaker and a micro-microphone; the computer is internally provided with an auditory sensitivity comprehensive detection system which comprises a sound card driving system and a test execution system; the sound card driving system is used for driving the sound card to receive the signal sent by the computer and sending the signal to the ear of the subject through the micro loudspeaker; simultaneously driving the sound card to receive the signal sent back by the miniature microphone and sending the signal to a test execution system; the test execution system comprises an SFOAEs-based intensity sensitivity detection module and an SFOAEs-based frequency sensitivity detection module, wherein the SFOAEs-based intensity sensitivity detection module is used for determining an auditory intensity threshold value corresponding to each frequency point by detecting the stimulation frequency otoacoustic emission data of each frequency point; the SFOAEs-based frequency sensitivity detection module is used for extracting the otoacoustic emission suppression tuning curve of the stimulation frequency at a specified frequency point and determining the frequency sensitivity at the specified frequency point.
Further, the SFOAEs-based intensity sensitivity detection module comprises a stimulus sound parameter setting module, an inhibition sound parameter setting module, a stimulus sound signal generating module, an inhibition sound signal generating module, a stimulus sound signal stimulating module, an inhibition sound signal stimulating module, a detection signal collecting module, a signal processing module, a frequency domain waveform display module, a test data display module, an intensity sensitivity conversion module and a test result report generating and storing module; the stimulation sound parameter setting module is used for setting stimulation sound frequency, frequency band range, stimulation sound frequency test step length and stimulation intensity; the suppressed sound parameter setting module is used for setting the frequency and the intensity of suppressed sound; the stimulating sound signal generating module and the suppressing sound signal generating module respectively generate corresponding digital stimulating sound signals and digital suppressing sound signals according to set parameters and send corresponding signals to the stimulating sound signal stimulating module and the suppressing sound signal stimulating module; the stimulating sound signal stimulating module and the inhibiting sound signal stimulating module send out stimulating sound signals and inhibiting sound signals to the ears of a testee through the sound card and the micro loudspeaker, the micro microphone receives signals sent back by the external auditory canal of the testee, amplifies the signals and sends the amplified signals to the sound card, the sound card carries out A/D conversion on the signals and sends the signals to the detection signal acquisition module, the detection signal acquisition module sends the acquired signals to the signal processing module, the signal processing module extracts stimulating frequency otoacoustic emissions under different stimulating frequencies and respectively sends detection results to the frequency domain waveform display module, the test data display module, the intensity sensitivity conversion module and the test result report generation and storage module, and the waveform display module dynamically displays the amplitude, the baseline and the position of SFOAEs in different frequencies, The waveform of the phase and noise; the test data display module dynamically displays detection data of the SFOAEs under different frequencies, wherein the detection data comprises amplitude, waveform, phase, baseline and noise, the intensity sensitivity conversion module carries out grouping according to the detection frequency, carries out cluster analysis in each group according to the amplitude, the waveform, the baseline and the noise, and obtains a specific intensity sensitivity value according to a priori mathematical relationship model; the test result report generating and storing module is used for generating and storing all the test results and test information of the testee.
Further, the specific calculation process of the intensity sensitivity conversion module is as follows: the signal spectrum appearing at the detection frequency is classified into four categories:
the first type: no pure tone spectrum is present or below 0dB for signal to noise ratio;
the second type: pure tone spectrum occurs and the signal to noise ratio is higher than 10 dB;
in the third category: pure tone spectra occur with signal-to-noise ratios between 5dB and 10 dB;
the fourth type: pure tone frequency spectrum appears and the signal-to-noise ratio is between 5dB and 0 dB;
performing secondary classification on the first class, judging that the detection fails if no pure tone spectrum appears, detecting again or performing frequency conversion detection, and setting the strength sensitivity of the SFOAEs (the SFOAE amplitude-baseline amplitude) as a (the SFOAE amplitude-baseline amplitude) for the signal-to-noise ratio lower than 0dB but higher than the baseline by 6dB, wherein the a value is set according to different frequencies;
for the second class, performing secondary classification when a pure tone spectrum appears and the signal-to-noise ratio is higher than 10dB, and for the class with the base line higher than the noise by more than 3dB, setting the SFOAEs intensity sensitivity as b (SFOAE amplitude-base line amplitude) + c (SFOAE base line amplitude-noise amplitude), wherein the b and c values are set according to different frequencies; if the base line is larger than the noise value and is smaller than 3dB, the mathematical model of the SFOAEs intensity sensitivity is d (SFOAE amplitude-base line amplitude), and the d value is set according to different frequencies;
for the third category, performing secondary classification when a pure tone spectrum appears and the signal-to-noise ratio is between 5dB and 10dB, wherein for a baseline higher than noise, the SFOAEs intensity sensitivity is e (SFOAE amplitude-f) and for a baseline lower than noise, the SFOAEs intensity sensitivity is g (SFOAE amplitude-h) and the e, f, g and h values are set according to different frequencies;
for the fourth category, pure tone spectrum appears and the signal-to-noise ratio is between 5dB-0dB, the second classification is performed, for the baseline higher than noise, the SFOAEs intensity sensitivity is i (SFOAE amplitude-j noise amplitude), for the baseline lower than noise, the SFOAEs intensity sensitivity is k (SFOAE amplitude-l baseline amplitude), and the values of i, j, k, and l are set according to the frequency.
Furthermore, the SFOAEs frequency sensitivity detection module comprises a stimulus sound parameter setting module, an inhibition sound parameter setting module, a stimulus sound signal generating module, an inhibition sound signal generating module, a stimulus sound signal stimulating module, an inhibition sound signal stimulating module, a detection signal collecting module, a detection signal processing module, an SFOAE STCs waveform display module, a test data display module, a frequency sensitivity conversion module, and a test result report generating and storing module; the stimulation sound parameter setting module is used for setting stimulation sound frequency and stimulation sound intensity; the suppression sound parameter setting module is used for setting a suppression sound frequency upper limit, a suppression sound frequency lower limit, a suppression sound frequency step length and a suppression criterion; the stimulating sound signal generating module and the suppressing sound signal generating module generate corresponding digital stimulating signals and digital suppressing signals according to set parameters; the stimulation sound signal stimulation module and the inhibition sound signal stimulation module send stimulation sound under stimulation frequency and inhibition sound with different frequencies and different intensities to ears of a subject through the sound card and the micro loudspeaker, the frequency of the inhibition sound is adjusted in a range around the stimulation frequency by a set inhibition sound frequency step length, the micro microphone amplifies signals in ear canals and then sends the amplified signals to the sound card, and finally the amplified signals are transmitted to the detection signal processing module through the detection signal acquisition module, the detection signal processing module extracts the stimulation frequency otoacoustic emission meeting set inhibition criteria under each inhibition frequency in an inhibition sound frequency range to obtain a test result of an SFOAE STCs curve, and the SFOAE STCs waveform display module is used for displaying a test waveform; the test data display module dynamically displays the detection data of the SFOAE STCs under different frequencies, the frequency sensitivity conversion module groups the detection frequencies, performs cluster classification according to the amplitude, waveform, base line and noise of SFOAE STCs curves in each group, and obtains a specific frequency sensitivity value according to a priori mathematical relationship model; the test result report generating and storing module is used for generating and storing all the test results and test information of the testee.
Further, the specific calculation process of the frequency sensitivity conversion module is as follows: dividing the SFOAE STCs into two types according to the curve shape and the position of the SFOAE STCs appearing at the detection frequency, wherein the first type is an SFOAE STCs curve with double vertexes, and the second type is an SFOAE STCs curve with single vertex;
for the first category, the SFOAE STCs curves with double vertices were binned, with frequency sensitivity a Q10+ b high-end slope-c low-end slope if the vertices were above the stimulus sound intensity and a Q10 if the vertices were below the stimulus sound intensity;
for the second type of SFOAE STCs curve with a single vertex, if the right offset is found, the frequency sensitivity is d × Q10+ e (high-end slope-f × low-end slope), if the left offset is found, the frequency sensitivity is g × Q10+ h (high-end slope), and if the left offset is not found, the frequency sensitivity is i × Q10, wherein Q10 is a quality factor at 10dB point, and different values of a, b, c, d, e, f, g, and h are selected according to the detected frequency.
Furthermore, the detection system also comprises a pure tone audiometry detection module with the resolution of 1dB, wherein the pure tone audiometry detection module obtains an audiometric threshold with the resolution of 1dB at each frequency point by adopting a subjective behavior method, and is used for comparing the audiometric threshold with the result of the SFOAEs-based intensity sensitivity detection module and establishing a model relation between the SFOAEs-based intensity detection and the audiometric threshold of the pure tone audiometric.
Further, the detection system also comprises a psychophysical tuning curve detection module, wherein the psychophysical tuning curve detection module obtains the frequency sensitivity at a specified frequency point by adopting a subjective behavior method, compares the frequency sensitivity with the result of the SFOAEs-based frequency sensitivity detection module, and establishes a model relation between the frequency sensitivity detection result based on the SFOAEs and the frequency sensitivity detection result of the PTCs.
Furthermore, the detection system also comprises a preamplifier, wherein the input end of the preamplifier is connected with the output end of the miniature microphone, and the output end of the preamplifier is connected with the sound card.
Further, the detection system also comprises a signal feedback device which is connected with the computer and is used for the subject to perform signal feedback and sending the feedback result of the subject to the computer; the signal feedback device adopts a handle, and the handle is connected with the computer through a USB interface.
Due to the adoption of the technical scheme, the invention has the following advantages: 1. the test module (comprising a conventional test module and a test module under a specified frequency point) based on the SFOAEs intensity sensitivity is used for objectively, quantitatively and quickly extracting the intensity sensitivity under the set frequency point, and can objectively detect the hearing threshold clinically. 2. The test based on the stimulus frequency otoacoustic emission inhibition tuning curves (SFOAE STCs) realizes quantitative and objective detection of frequency resolution sensitivity at different frequencies, and is compared with a resolution result of the frequency sensitivity detected by Psychophysical Tuning Curves (PTCs) in subjective behavior reaction, so that the quantitative detection of the frequency resolution sensitivity can be realized clinically. 3. In the invention, under the condition that both the frequency domain and the time domain of the SFOAEs are mixed with the stimulus sound, weak SFOAEs signals are extracted, the intensity sensitivity (hearing threshold) of the auditory system is objectively and quantitatively reflected by the intensity of the SFOAEs signals, a stimulus frequency otoacoustic emission suppression tuning curve (SFOAE STCs) is a tuning curve under a certain stimulus frequency, has the potential of reflecting the cochlea resolution frequency sensitivity under the frequency, and objectively and quantitatively reflects the frequency sensitivity of the auditory system by the SFOAE STCs.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic diagram of the test execution system of the present invention;
FIG. 3 is a schematic diagram of the SFOAEs-based intensity sensitivity routine detection module of the present invention;
FIG. 4 is a schematic diagram of the SFOAE STCs-based frequency sensitivity detection module of the present invention;
FIG. 5 is a schematic flow diagram of the pure tone audiometric test module of the present invention with a resolution of 1 dB;
FIG. 6 is a flow chart of the Psychophysical Tuning Curves (PTCs) detection module of the present invention.
Detailed Description
The present invention is described in detail below with reference to the attached drawings. It is to be understood, however, that the drawings are provided solely for the purposes of promoting an understanding of the invention and that they are not to be construed as limiting the invention.
As shown in fig. 1, the auditory sensitivity detection system based on the otoacoustic emission at the stimulation frequency provided by the invention is used for acquiring the intensity sensitivity and the frequency sensitivity of the otoacoustic emission at the stimulation frequency, and comprises a computer 1, a sound card 2, an acoustic sensor (miniature probe) 3, a preamplifier and a signal feedback device; the acoustic sensor 3 includes a micro speaker 31 and a micro microphone 32, and the micro speaker 31 and the micro microphone 32 may be inserted into the same soft earplug in order to isolate the sound in the external auditory canal of the subject from the external sound.
The sound card 2 adopts a multimedia sound card which can be connected with the computer 1 and is used for converting digital signals sent by the computer 1 into analog voltage signals, and when the detection is carried out, a portable multimedia sound card which is produced by RME company and has 24bit sampling depth and the highest sampling rate of 192kHz is adopted to be connected with the computer 1 through an IEEE1394 interface, for example, but not limited to the above, the sound card 2 can also adopt other structural forms and connection modes, such as a multimedia sound card or a common sound card which is connected with the computer 1 through a USB interface.
The micro-speaker 31 includes two electro-acoustic transducers for respectively generating stimulating sound and suppressing sound for inducing the stimulating frequency otoacoustic emission signal, the two electro-acoustic transducers are inserted in the ear plugs through two sound tubes, the input ends of the two electro-acoustic transducers are respectively connected with the sound card 2 through two TRS interfaces for electro-acoustically converting the analog voltage signal into the sound signal, and the sound signal is transmitted to the ears of the subject through the ear plugs. The micro-speaker 31 may be implemented in a variety of products known in the art, such as the ER2 insert earphone from Etymotic for testing purposes.
The miniature microphone 32 includes an acousto-electric transducer for collecting the otoacoustic emission signal and other signals in the external auditory canal of the human ear and converting the collected acoustic signals into electrical signals, the input end of the miniature microphone 32 is inserted into the earplug via a transmission sound tube, the sound signal in the ear canal is converted into an analog voltage signal by the transmission sound tube to the acousto-electric transducer, and the output end of the miniature microphone 32 is connected to the input end of the preamplifier. The miniature microphone 32 may be any of a variety of products known in the art, such as ER-10B + from Etymotic, USA, for testing in accordance with the present invention.
The preamplifier is used for amplifying the signal output by the miniature microphone 32, the amplification factor can be adjusted according to actual needs, and the adjustment factor can be selected from 0dB, 20dB and 40 dB. In order to avoid signal interference caused by a grounding loop, the preamplifier is powered by two 9V batteries, and the output end of the preamplifier is connected with the sound card 2.
The signal feedback device is connected with the computer 1 and used for the subject to perform signal feedback and sending the feedback result of the subject to the computer 1, the signal feedback device can adopt various devices, the signal feedback device of the invention adopts a handle 4, and the handle 4 is connected with the computer 1 through a USB interface.
As shown in fig. 2, the computer 1 is provided with an auditory sensitivity comprehensive detection system, which includes a sound card driving system and a test execution system. The sound card driving system is used for driving the sound card 2 to receive the signal sent by the computer 1 and sending the signal to the ear of the subject through the micro loudspeaker 31; the sound card 2 is simultaneously driven to receive the signal sent back by the preamplifier and send it to the test execution system.
The test execution system comprises an intensity sensitivity detection module based on SFOAEs, a frequency sensitivity detection module based on SFOAEs, a pure tone audiometry (PT) detection module with the resolution of 1dB and a detection module based on Psychophysical Tuning Curves (PTCs).
The detection module based on the strength sensitivity of the SFOAEs is used for determining the hearing strength threshold value corresponding to the corresponding frequency point by detecting the amplitude, waveform, baseline, phase and noise of the otoacoustic emission of the stimulation frequency of each frequency point;
the SFOAEs-based frequency sensitivity detection module is used for extracting a stimulation frequency otoacoustic emission suppression tuning curve (SFOAE STCs) at a specified frequency point and determining the frequency sensitivity at the specified frequency point;
the pure tone audiometry detection module with the resolution of 1dB obtains an audiometric threshold with the resolution of 1dB at each frequency point by adopting a subjective behavior method, and is used for comparing the audiometric threshold with the result of the SFOAEs-based intensity sensitivity detection module, and establishing a model relation between the SFOAEs-based intensity detection and the pure tone audiometric auditory threshold in an early stage, so that the SFOAEs-based intensity sensitivity detection which can be consistent with the clinical pure tone audiometric detection result is realized;
the psychophysical tuning curve detection module obtains frequency sensitivity at a designated frequency point by adopting a subjective behavior method, and is used for comparing the frequency sensitivity with the result of the SFOAEs-based frequency sensitivity detection module, and establishing a model relation between the frequency sensitivity detection result based on the SFOAEs and the frequency sensitivity detection result of the PTCs in an early stage, so that the SFOAEs-based frequency sensitivity detection applied to clinic is realized.
In a preferred embodiment, as shown in fig. 3, the SFOAEs-based intensity sensitivity detection module is used for testing each frequency, and includes a stimulus sound parameter setting module, a suppression sound parameter setting module, a stimulus sound signal generation module, a suppression sound signal generation module, a stimulus sound signal stimulation module, a suppression sound signal stimulation module, a detection signal acquisition module, a signal processing module, a frequency domain waveform display module, a test data display module, an intensity sensitivity conversion module, and a test result report generation and storage module. The stimulating sound parameter setting module is used for setting the frequency, the frequency band range, the stimulating sound frequency testing step length and the stimulating intensity of the stimulating sound; the suppression sound parameter setting module is used for setting the frequency and the intensity of suppression sound; the stimulating sound signal generating module and the suppressing sound signal generating module respectively generate corresponding digital stimulating sound signals and digital suppressing sound signals according to the set parameters and send the corresponding signals to the stimulating sound signal stimulating module and the suppressing sound signal stimulating module; the stimulating sound signal stimulating module and the suppressing sound signal stimulating module send out stimulating sound signals and suppressing sound signals to the ears of a testee through the sound card 2 and the micro loudspeaker 31, the micro microphone 32 receives the signals sent back by the external auditory meatus of the testee, the signals are sent to the preamplifier to be amplified and then sent to the sound card 2, the sound card 2 carries out A/D conversion on the signals and sends the signals to the detection signal acquisition module, the detection signal acquisition module sends the acquired signals to the signal processing module, the signal processing module extracts stimulating frequency otoacoustic emission under different stimulating frequencies and sends detection results to the frequency domain waveform display module, the test data display module, the intensity sensitivity conversion module and the test result report generating and storing module respectively. The waveform display module dynamically displays the waveforms of the amplitude, the baseline, the phase and the noise of the detection data of the SFOAEs under different frequencies; the test data display module dynamically displays the detection data (amplitude, waveform, phase, baseline and noise) of the SFOAEs under different frequencies, and the intensity sensitivity conversion module carries out grouping according to the detection frequency; performing cluster analysis in each group according to the amplitude, the waveform, the base line and the noise, and obtaining a specific strength sensitivity value according to a prior mathematical relation model; the test result report generating and storing module is used for generating and storing all the test results and test information of the testee.
In a preferred embodiment, the intensity sensitivity conversion module groups according to the detection frequency, performs cluster analysis in each group according to the amplitude, waveform, baseline and noise, and obtains a specific intensity sensitivity value according to a prior mathematical relationship model, which comprises the following specific processes:
the signal spectrum appearing at the detection frequency is classified into four categories:
the first type: no pure tone signal spectrum is present or below 0dB for signal to noise ratio;
the second type: pure tone spectrum occurs and the signal to noise ratio is higher than 10 dB;
in the third category: pure tone spectra occur with signal-to-noise ratios between 5dB and 10 dB;
the fourth type: pure tone spectrum occurs and the signal-to-noise ratio is between 5 dB-0;
in the first class, secondary classification is carried out again, if no pure tone signal spectrum appears, the detection is judged to be failed, re-detection or frequency conversion detection (possibly overlapping with SOAE) is carried out, and for the signal-to-noise ratio lower than 0dB but higher than the baseline by 6dB, the SFOAEs intensity sensitivity is a (SFOAE amplitude-baseline amplitude), and the a value is set according to different frequencies;
for the second class, pure tone frequency spectrum appears and the signal-to-noise ratio is higher than 10dB, secondary classification is carried out, for the class with the base line higher than the noise by 3dB, the SFOAEs intensity sensitivity is b (SFOAE amplitude-base line amplitude) + c (SFOAE base line amplitude-noise amplitude), and proper b and c values are selected according to different detected frequencies; for baseline values greater than the noise value by less than 3dB, the SFOAEs intensity sensitivity mathematical model is d (SFOAE amplitude-baseline amplitude). Selecting different d values according to different detected frequencies;
for the third class, a pure tone spectrum appears, the signal-to-noise ratio is between 5dB and 10dB, secondary classification is carried out, for the base line higher than noise, the SFOAEs intensity sensitivity is e (SFOAE amplitude-f base line amplitude), for the base line lower than noise, the SFOAEs intensity sensitivity is g (SFOAE amplitude-h noise amplitude), different values of e, f, g and h are selected according to different detected frequencies;
for the fourth category, pure tone spectra occur with signal-to-noise ratios between 5 dB-0; then, secondary classification is performed, and for baseline higher than noise, SFOAEs intensity sensitivity is equal to i (SFOAE amplitude-j noise amplitude), and for baseline lower than noise, SFOAEs intensity sensitivity is equal to k (SFOAE amplitude-l baseline amplitude), and different values of i, j, k, and l are selected according to different detected frequencies
In a preferred embodiment, as shown in fig. 4, the SFOAEs frequency sensitivity detection module includes a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generation module, a suppression sound signal generation module, a stimulation sound signal stimulation module, a suppression sound signal stimulation module, a detection signal acquisition module, a detection signal processing module, an SFOAEs STCs waveform display module, a test data display module, a frequency sensitivity conversion module, and a test result report generation and storage module. The stimulation sound parameter setting module is used for setting stimulation sound frequency and stimulation sound intensity; the suppression sound parameter setting module is used for setting a suppression sound frequency upper limit, a suppression sound frequency lower limit, a suppression sound frequency step length and a suppression criterion; the stimulating sound signal generating module and the suppressing sound signal generating module generate corresponding digital stimulating signals and digital suppressing signals according to the set parameters; the stimulating sound signal stimulating module and the suppressing sound signal stimulating module send out stimulating sound under stimulating frequency and suppressing sound with different frequencies and different intensities to ears of a subject through the sound card 2 and the micro loudspeaker 31, the frequency of the suppressing sound is adjusted in a range around the stimulating frequency by a set suppressing sound frequency step length, the micro microphone 32 sends signals in ear canals to the sound card 2 through the preamplifier, and finally the signals are transmitted to the detection signal processing module through the detection signal acquisition module, the detection signal processing module extracts stimulating frequency ear sound emission meeting set suppressing criteria under each suppressing frequency in a suppressing sound frequency range, and the specific process is as follows: continuously increasing or decreasing the intensity of the suppression sound, stopping adjustment when the residual quantity of the otoacoustic emission of the stimulation frequency reaches a set suppression criterion, and determining the point (the corresponding suppression frequency point and the suppression intensity) at the moment as one point in the otoacoustic emission tuning curve of the stimulation frequency; measuring the next inhibition frequency point by analogy, connecting points under different inhibition frequencies in the inhibition frequency range point by point to obtain a test result of the otoacoustic emission tuning curve of the stimulation frequency, wherein the SFOAE STCs waveform display module is used for displaying a test waveform; the test data display module dynamically displays the detection data (amplitude, baseline and noise) of the SFOAE STCs at different frequencies; the frequency sensitivity conversion module firstly carries out grouping according to the detection frequency; then, in each group, carrying out cluster classification according to the amplitude, waveform, base line and noise of the SFOAE STCs curve; in different classes, specific frequency sensitivity values are obtained according to a prior mathematical relation model; the test result report generating and storing module is used for generating and storing all the test results and test information of the testee.
In a preferred embodiment, the frequency sensitivity conversion modules are firstly grouped according to the detection frequency; then, in each group, carrying out cluster classification according to the amplitude, waveform, base line and noise of the SFOAE STCs curve; in different classes, according to the prior mathematical relationship model, the specific process of obtaining the specific frequency sensitivity value is as follows:
the two categories are based on the shape and position of the SFOAE STCs occurring at the detection frequency, the SFOAE STCs curves that occur double-vertex and that occur single-vertex.
For the first category, a double-vertex SFOAE STCs curve is generated, and then secondary classification is performed, if the vertex is higher than the stimulus sound intensity, the frequency sensitivity is a × Q10 (quality factor at 10 dB) + b × high-end slope-c × low-end slope, and if the vertex is lower than the stimulus sound intensity, the frequency sensitivity is a × Q10 (quality factor at 10 dB);
2) for the second type of SFOAE STCs curve with a single vertex, if the right is shifted, the frequency sensitivity is d × Q10 (quality factor at 10 Db) + e (high-end slope-f × low-end slope), if the left is shifted, the frequency sensitivity is g × Q10 (quality factor at 10 Db) + h (high-end slope), if the left is not shifted, the frequency sensitivity is i × Q10 (quality factor at 10 Db), and different values of a, b, c, d, e, f, g, and h are selected according to the detected frequencies.
In a preferred embodiment, as shown in fig. 5, the pure tone audiometric detection module with a resolution of 1dB includes a handle configuration module, a feedback signal receiving module, a test type selection module, a test parameter selection module, a test control analysis module, a pure tone signal stimulation module, a result analysis module, and a display module; the handle configuration module is used for performing binding configuration on the buttons of the handle 4 and sending a binding configuration result to the feedback signal receiving module; the test type selection module is used for selecting test types (the selectable test types comprise a lifting method and a lifting method); the test parameter selection module is used for setting a test method, a test frequency and upper and lower limits of pure tone intensity; the test control analysis module sends a test frequency and a pure tone initial test intensity to the pure tone signal stimulation module according to the selected test method and test parameters, the pure tone signal stimulation module sends a digital pure tone stimulation signal to the ears of a subject, the feedback signal receiving module receives a judgment result fed back by the subject through a handle button and sends the judgment result back to the test control analysis module, the test control analysis module increases or decreases the pure tone intensity according to the result to obtain an auditory threshold value stimulated by the pure tone signal and sends the auditory threshold value to the result analysis module for storage or updating, and meanwhile, whether the auditory threshold values of all the test frequencies are obtained is judged; if the signals are obtained, an audiogram is drawn and sent to a display module for display, and a pure tone audiometric detection module with the resolution of 1dB is used for establishing a mathematical model relation with an SFOAEs-based intensity test result in early-stage large data volume analysis, so that SFOAEs-based intensity sensitivity detection which can be consistent with a clinical pure tone audiometric detection result is realized.
In a preferred embodiment, as shown in fig. 6, the psychophysical tuning curve-based detection module includes a handle configuration module, a test parameter selection module, a test signal generation module, a test control module, a test signal stimulation module, a feedback signal receiving module, a result analysis module and a display module; the handle configuration module is used for performing binding configuration on the buttons of the handle 4 and sending a binding configuration result to the feedback signal receiving module; the test parameter selection module sets the upper limit of the stimulus sound frequency, the stimulus sound intensity and the masking sound intensity; the test signal generation module generates pure tone stimulating sound and sweep frequency narrowband masking sound according to the received test parameters, sends the pure tone stimulating sound and the sweep frequency narrowband masking sound to the test control module, and sends a signal to the test signal stimulation module by the test control module so as to enable the test signal stimulation module to send out the stimulating sound and the masking sound; the feedback signal receiving module receives the judgment result fed back by the subject through the handle button, and sends the judgment result back to the test control module, the test control module increases or decreases the masking sound intensity according to the result, and records the masking sound intensity in real time, and sends the recorded value to the result analysis module, the result analysis module draws a masking sound intensity change diagram, and carries out smooth and positive and negative average processing to obtain a psychophysical tuning curve, and sends the psychophysical tuning curve to the display module for displaying, the frequency sensitivity detection module based on the psychophysical tuning curve is used for establishing a mathematical model relationship with the test result of the suppression tuning curve based on SFOAEs in the early large data volume analysis, and prepares for obtaining the detection result of the frequency sensitivity based on SFOAE STCs,
in a preferred embodiment, the detection signal acquisition modules of the SFOAEs-based intensity sensitivity detection module and the SFOAEs-based frequency sensitivity detection module, that is, the test signal extraction of the otoacoustic emission at the stimulation frequency, and the method for extracting the otoacoustic emission at the stimulation frequency is substantially the same, and mainly includes three existing methods: nonlinear compression, two-tone suppression and frequency spectrum smoothing processing, wherein each method utilizes a different cochlear phenomenon or signal processing technology to extract the stimulus frequency otoacoustic emission, and the nonlinear compression method fully utilizes the linear growth relation between the compression growth of the stimulus frequency otoacoustic emission amplitude and the stimulus sound; the method of binaural suppression is to define SFOAEs as the composite difference between the ear canal sound pressure detected by increasing the suppressed sound and not increasing the suppressed sound near the stimulation frequency, considering that the suppressed sound can substantially reduce or eliminate otoacoustic emissions; the spectrum smoothing process is to convolute the spectrum of the sound pressure of the composite auditory canal by using a smoothing function, and the analysis method is to use the fact that the latencies of the stimulated sound and the otoacoustic emission are different and is equivalent to windowing in the corresponding latency area.
The above embodiments are only used for illustrating the present invention, and the structure, connection mode, manufacturing process, etc. of the components may be changed, and all equivalent changes and modifications performed on the basis of the technical solution of the present invention should not be excluded from the protection scope of the present invention.
Claims (8)
1. An auditory sensitivity detection system based on the otoacoustic emission at a stimulation frequency, which is characterized by comprising a sound card, an acoustic sensor and a computer, wherein the acoustic sensor comprises a micro-speaker and a micro-microphone; the computer is internally provided with an auditory sensitivity comprehensive detection system which comprises a sound card driving system and a test execution system;
the sound card driving system is used for driving the sound card to receive the signal sent by the computer and sending the signal to the ear of the subject through the micro loudspeaker; simultaneously driving the sound card to receive the signal sent back by the miniature microphone and sending the signal to a test execution system;
the test execution system comprises an SFOAEs-based intensity sensitivity detection module and an SFOAEs-based frequency sensitivity detection module, wherein the SFOAEs-based intensity sensitivity detection module is used for determining an auditory intensity threshold value corresponding to each frequency point by detecting the stimulation frequency otoacoustic emission data of each frequency point; the SFOAEs-based frequency sensitivity detection module is used for extracting an SFOAE STCs curve at a specified frequency point and determining the frequency sensitivity at the specified frequency point, wherein the SFOAESTCs curve is a stimulation frequency otoacoustic emission inhibition tuning curve; the SFOAEs-based frequency sensitivity detection module is provided with a frequency sensitivity conversion module, and the specific calculation process of the frequency sensitivity conversion module is as follows:
dividing the SFOAE STCs into two types according to the curve shape and the position of the SFOAE STCs appearing at the detection frequency, wherein the first type is an SFOAE STCs curve with double vertexes, and the second type is an SFOAE STCs curve with single vertex;
for the first category, the SFOAE STCs curves with double vertices were binned, with frequency sensitivity a Q10+ b high-end slope-c low-end slope if the vertices were above the stimulus sound intensity and a Q10 if the vertices were below the stimulus sound intensity;
for the second type of SFOAE STCs curve with a single vertex, if the right offset is found, the frequency sensitivity is d × Q10+ e (high-end slope-f × low-end slope), if the left offset is found, the frequency sensitivity is g × Q10+ h (high-end slope), and if the left offset is not found, the frequency sensitivity is i × Q10, wherein Q10 is a quality factor at 10dB point, and different values of a, b, c, d, e, f, g, and h are selected according to the detected frequency.
2. The otoacoustic emission-based auditory sensitivity detection system according to claim 1, wherein the SFOAEs-based intensity sensitivity detection module comprises a stimulus sound parameter setting module, a suppression sound parameter setting module, a stimulus sound signal generation module, a suppression sound signal generation module, a stimulus sound signal stimulation module, a suppression sound signal stimulation module, a detection signal acquisition module, a signal processing module, a frequency domain waveform display module, a test data display module, an intensity sensitivity conversion module, and a test result report generation and storage module;
the stimulation sound parameter setting module is used for setting stimulation sound frequency, frequency band range, stimulation sound frequency test step length and stimulation intensity; the suppressed sound parameter setting module is used for setting the frequency and the intensity of suppressed sound; the stimulating sound signal generating module and the suppressing sound signal generating module respectively generate corresponding digital stimulating sound signals and digital suppressing sound signals according to set parameters and send corresponding signals to the stimulating sound signal stimulating module and the suppressing sound signal stimulating module; the stimulating sound signal stimulating module and the inhibiting sound signal stimulating module send out stimulating sound signals and inhibiting sound signals to the ears of a testee through the sound card and the micro loudspeaker, the micro microphone receives signals sent back by the external auditory canal of the testee, amplifies the signals and sends the amplified signals to the sound card, the sound card carries out A/D conversion on the signals and sends the signals to the detection signal acquisition module, the detection signal acquisition module sends the acquired signals to the signal processing module, the signal processing module extracts stimulating frequency otoacoustic emissions under different stimulating frequencies and respectively sends detection results to the frequency domain waveform display module, the test data display module, the intensity sensitivity conversion module and the test result report generation and storage module, and the waveform display module dynamically displays the amplitude, the baseline and the position of SFOAEs in different frequencies, The waveform of the phase and noise; the test data display module dynamically displays detection data of the SFOAEs under different frequencies, wherein the detection data comprises amplitude, waveform, phase, baseline and noise, the intensity sensitivity conversion module carries out grouping according to the detection frequency, carries out cluster analysis in each group according to the amplitude, the waveform, the baseline and the noise, and obtains a specific intensity sensitivity value according to a priori mathematical relationship model; the test result report generating and storing module is used for generating and storing all the test results and test information of the testee.
3. The auditory sensitivity detection system based on stimulus frequency otoacoustic emissions of claim 2, wherein the intensity sensitivity conversion module is specifically calculated by: the signal spectrum appearing at the detection frequency is classified into four categories:
the first type: no pure tone spectrum is present or below 0dB for signal to noise ratio;
the second type: pure tone spectrum occurs and the signal to noise ratio is higher than 10 dB;
in the third category: pure tone spectra occur with signal-to-noise ratios between 5dB and 10 dB;
the fourth type: pure tone frequency spectrum appears and the signal-to-noise ratio is between 5dB and 0 dB;
performing secondary classification on the first class, judging that the detection fails if no pure tone spectrum appears, detecting again or performing frequency conversion detection, and setting the strength sensitivity of the SFOAEs (the SFOAE amplitude-baseline amplitude) as a (the SFOAE amplitude-baseline amplitude) for the signal-to-noise ratio lower than 0dB but higher than the baseline by 6dB, wherein the a value is set according to different frequencies;
for the second class, performing secondary classification when a pure tone spectrum appears and the signal-to-noise ratio is higher than 10dB, and for the class with the base line higher than the noise by more than 3dB, setting the SFOAEs intensity sensitivity as b (SFOAE amplitude-base line amplitude) + c (SFOAE base line amplitude-noise amplitude), wherein the b and c values are set according to different frequencies; if the base line is larger than the noise value and is smaller than 3dB, the mathematical model of the SFOAEs intensity sensitivity is d (SFOAE amplitude-base line amplitude), and the d value is set according to different frequencies;
for the third category, performing secondary classification when a pure tone spectrum appears and the signal-to-noise ratio is between 5dB and 10dB, wherein for a baseline higher than noise, the SFOAEs intensity sensitivity is e (SFOAE amplitude-f) and for a baseline lower than noise, the SFOAEs intensity sensitivity is g (SFOAE amplitude-h) and the e, f, g and h values are set according to different frequencies;
for the fourth category, pure tone spectrum appears and the signal-to-noise ratio is between 5dB-0dB, the second classification is performed, for the baseline higher than noise, the SFOAEs intensity sensitivity is i (SFOAE amplitude-j noise amplitude), for the baseline lower than noise, the SFOAEs intensity sensitivity is k (SFOAE amplitude-l baseline amplitude), and the values of i, j, k, and l are set according to the frequency.
4. The otoacoustic emission-based auditory sensitivity detection system according to claim 1 or 2, wherein the SFOAEs frequency sensitivity detection module further comprises a stimulus sound parameter setting module, a suppression sound parameter setting module, a stimulus sound signal generation module, a suppression sound signal generation module, a stimulus sound signal stimulation module, a suppression sound signal stimulation module, a detection signal acquisition module, a detection signal processing module, an SFOAE STCs waveform display module, a test data display module, a test result report generation and storage module; the stimulation sound parameter setting module is used for setting stimulation sound frequency and stimulation sound intensity; the suppression sound parameter setting module is used for setting a suppression sound frequency upper limit, a suppression sound frequency lower limit, a suppression sound frequency step length and a suppression criterion; the stimulating sound signal generating module and the suppressing sound signal generating module generate corresponding digital stimulating signals and digital suppressing signals according to set parameters; the stimulation sound signal stimulation module and the inhibition sound signal stimulation module send stimulation sound under stimulation frequency and inhibition sound with different frequencies and different intensities to ears of a subject through the sound card and the micro loudspeaker, the frequency of the inhibition sound is adjusted in a range around the stimulation frequency by a set inhibition sound frequency step length, the micro microphone amplifies signals in ear canals and then sends the amplified signals to the sound card, and finally the amplified signals are transmitted to the detection signal processing module through the detection signal acquisition module, the detection signal processing module extracts the stimulation frequency otoacoustic emission meeting set inhibition criteria under each inhibition frequency in an inhibition sound frequency range to obtain a test result of an SFOAE STCs curve, and the SFOAE STCs waveform display module is used for displaying a test waveform; the test data display module dynamically displays the detection data of the SFOAE STCs under different frequencies, the frequency sensitivity conversion module groups the detection frequencies, performs cluster classification according to the amplitude, waveform, base line and noise of SFOAE STCs curves in each group, and obtains a specific frequency sensitivity value according to a priori mathematical relationship model; the test result report generating and storing module is used for generating and storing all the test results and test information of the testee.
5. The otoacoustic emission-based auditory sensitivity detection system according to claim 1, further comprising a pure tone audiometric detection module with a resolution of 1dB, wherein the pure tone audiometric detection module employs a subjective behavior method to obtain an audiometric threshold with a resolution of 1dB at each frequency point for comparison with the results of the SFOAEs-based intensity sensitivity detection module to establish a model relationship between SFOAEs-based intensity detection and the audiometric threshold of pure tone audiometric.
6. An otoacoustic sensitivity detection system as claimed in claim 1, wherein the detection system further comprises a psychophysical tuning curve detection module, the psychophysical tuning curve detection module using a subjective behavioral method to obtain frequency sensitivity at a designated frequency point for comparison with results of the SFOAEs-based frequency sensitivity detection module by establishing a model relationship between the SFOAEs-based frequency sensitivity detection results and frequency sensitivity detection results of PTCs, wherein the PTCs are psychophysical tuning curves.
7. An auditory sensitivity detection system according to claim 1 based on stimulation frequency otoacoustic emissions, further comprising a preamplifier, the input of which is connected to the output of the microphone and the output of which is connected to the sound card.
8. An auditory sensitivity detection system according to claim 6, which is based on the otoacoustic emission at the stimulation frequency, and is characterized in that the detection system further comprises a signal feedback device, which is connected with the computer and is used for the subject to perform signal feedback and send the feedback result of the subject to the computer; the signal feedback device adopts a handle, and the handle is connected with the computer through a USB interface.
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| CN109620251B (en) * | 2018-12-29 | 2024-05-14 | 天津工业大学 | Auditory noninvasive detection method based on composite nerve action potential |
| TWI693926B (en) * | 2019-03-27 | 2020-05-21 | 美律實業股份有限公司 | Hearing test system and setting method thereof |
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| CN111768834A (en) * | 2020-03-03 | 2020-10-13 | 天津工业大学 | Wearable intelligent hearing comprehensive detection analysis rehabilitation system |
| CN111631728B (en) * | 2020-05-26 | 2023-01-24 | 广州大学 | Method and device for measuring bone conduction transfer function and storage medium |
| CN111669676B (en) * | 2020-05-27 | 2021-06-08 | 中国科学院声学研究所 | Bone conduction earphone equalization method based on stimulation frequency otoacoustic emission |
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