WO2015035585A1

WO2015035585A1 - Shampoo composition containing complexing agent for efficiently preventing hair loss

Info

Publication number: WO2015035585A1
Application number: PCT/CN2013/083393
Authority: WO
Inventors: 胡卫华; 庄严
Original assignee: 拉芳家化股份有限公司
Priority date: 2013-09-12
Filing date: 2013-09-12
Publication date: 2015-03-19
Also published as: CN104168883B; CN104168883A

Abstract

The present invention relates to a shampoo composition containing a complexing agent for efficiently preventing hair loss, wherein, in addition to water, the shampoo contains: (A) 5.0% to 40% of an anionic surfactant by weight of the composition; (B) 1.0% to 10.0% of a composition of coconut oil-based amphoteric sodium acetate and alkyl glucoside by weight of the composition; (C) 0.1% to 10% of an anti-hair loss composite active material by weight of the composition, wherein the anti-hair loss composite active material is hydrolyzed soy proteins, amino acids, amino sugars, vitamin B groups, zinc salts, ginseng essence, arctium majus root essence and a composition of organic silicon and polyquaternary ammonium salts; and (D) 0.05% to 3.0% of a cationic polymer by weight of the composition.

Description

Instruction book

Fragrance compound containing high-efficiency anti-debinding agent

Technical field

The invention belongs to the field of daily chemicals, and particularly relates to a shampoo composition containing a high-efficiency anti-debonding agent.

Background technique

Hair is the first element of human beauty, and hair loss is a major social problem facing many people. Hair loss is the biggest damage to the appearance. It will affect the shape of the person, reduce the attractiveness and charm, and it will be a great blow to self-confidence. It will also affect career choice, marriage, and even future. The hair's growth cycle can be divided into raw to maintain normal 50-75 hairs per day. Abnormal hair loss or excessive shedding causes pathological hair loss. The main causes of hair loss include internal factors such as mental factors, congenital genetic factors and hormones, and nutritional factors such as protein, amino acids, and vitamins, as well as seborrheic alopecia. It is an object of the present invention to provide a shampoo composition comprising a synergistic anti-hair loss complex derived from plant and biochemical synthesis, which can promote hair growth, improve the ratio of long-term and rest periods of the head, and promote healthy formation. The scalp and hair help the hair loss to return to normal hair loss.

Summary of the invention

The anti-deodorizing composition of the present invention, in addition to water, the shampoo contains: the shampoo contains: (A) an anionic surfactant in an amount of from 0.5% to 40% by weight of the composition;

(B) a composition of 1. 0% to 10. 0% by weight of the composition of coconut oil amphoteric acid acetate and alkyl glucoside; (C) an anti-de-complexing active comprising from 0.1% to 10% by weight of the composition, said anti-de-complexing active comprising, in addition to water,

10 to 25% of the weight of the composite active ginseng essence;

Hydrolyzed soy protein comprising 1-5% by weight of the composite active;

a mixture of amino acids 4-20% by weight of the composite active substance, the amino acid mixture is arginine: acetyl tyrosine: citrulline: ornithine hydrochloride is mixed in a weight ratio of 1: 1: 1: 1:

a mixture of vitamin B groups of 3-10% by weight of the composite active substance, the vitamin B group mixture is vitamin B3: vitamin B5: vitamin H is mixed in a weight ratio of 1: 1: 1:

5-10% by weight of the complex active glucosamine hydrochloride;

Zinc gluconate, 1-5% by weight of the composite active;

May burdock root extract, 1-5% by weight of the composite active;

PEG-12 disiloxane based on 5% by weight of the composite active;

Polyquaternium-11 of 1-5% by weight of the composite active;

(D) a cationic polymer in an amount of from 0.05% to 3.0% by weight of the composition.

The shampoo composition of the present invention, wherein the anti-de-complexing active is hydrolyzed soy protein, an amino acid mixture containing arginine, acetyl tyrosine, citrulline, ornithine hydrochloride, glucosamine hydrochloride, A mixture of a vitamin B group containing vitamin B3, vitamin B5, vitamin H, zinc gluconate, ginseng essence, May burdock root essence and a combination of PEG-12 dimercaptosilicone oil and polyquaternium-11. The shampoo composition of the present invention, wherein the anionic surfactant is selected from the group consisting of: alkyl sulfate salts, alkyl polyoxyethylene ether sulfate salts, fatty acid monoglyceride sulfates, alkyl sulfonates, N-acyl groups At least one of a salt, an N-glutamate, and a thiophosphate salt. The shampoo composition of the present invention, wherein the ratio of the sodium cocoamphoacetate to the alkyl glucoside is

3: 1-1: 3. The shampoo composition of the present invention, wherein the cationic polymer is selected from the group consisting of at least one of a cationic cellulose polymer and a cationic guar polymer. Compared with the prior art, the present invention has the following advantages:

The shampoo composition of the present invention is a synergistic anti-hair loss complex derived from plant and biochemical synthesis, which can promote hair growth, improve the ratio of long-term and rest periods of the head, and promote the formation of healthy scalp and hair, and help The hair loss patient returns to normal hair loss rate.

BEST MODE FOR CARRYING OUT THE INVENTION The component selection and action of the present invention will be described in detail below. The shampoo composition of the present invention contains from 0.1% to 10% by weight of the composition, preferably from 5% to 10%, of the anti-de-complexing active, which is a clear pale yellow liquid with 。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。. The specific composition and activity of the anti-debonding active substance are as follows: Hydrolyzed soy protein (hydrolyzed soybean sulfurized peptide, MW "15000Da") can provide cell nutrition and growth regulation, and promote protein biosynthesis; amino acids including tyrosine, sulphuric acid , ornithine, citrulline is a precursor of protein and melanin; alcohol-based glucose strengthens the dermal papilla and its surrounding matrix; vitamin B group regulates cell nutrition; zinc salt regulates oil secretion; ginseng essence and May burdock root extract The substance can improve microcirculation; silicone and polyquaternium provide conditioning of the hair. The shampoo composition of the present invention comprises a composition of 5.0% to 40% by weight of the composition of ammonium lauryl sulfate and lauryl ammonium polyoxyethylene sulfate, the ammonium lauryl sulfate and lauryl polyoxyethylene acid. The ratio of ammonium sulfate is 1: 2 - 2: 1. The ammonium lauryl citrate is abbreviated as K ₁₂ A or SLSA, and its structural formula is:

ROS0 ₃ NH ₄ ⁺ , R=C ₁₂ _C ₁₆ fluorenyl group, having an active content of 70%, and its appearance is a white or pale yellow paste. The ammonium lauryl sulfate has a mild action, can leave a good conditioning on the hair, has good bubble performance and cleaning performance, and can provide better compatibility for the appearance and viscosity rheological properties of the product. The fatty alcohol polyoxyethylene ether LS LS is referred to as AESA, and its structural formula is

RO (CH ₂ CH ₂ 0) _n SO phos +, R = C ₁₂ _C ₁₆ alkyl, n is 2 - 3, preferably the average degree of ethoxylation is n = 3. The commercial product of the ammonium laureth sulfate ammonium sulfate product has an active content of 70%, and its appearance is a white or pale yellow paste. The lauryl polyoxyethylene ether ammonium sulfate also has the characteristics of a nonionic surfactant, and still has a good detergency in hard water. The combination of ammonium lauryl sulfate and lauryl polyoxyethylene §4 ammonium sulfate can produce good synergistic effects, such as: good washing ability, excellent mildness and excellent thickening performance. The composition of the shampoo composition of the present invention comprises from 1.0% to 1.0% by weight of the composition of sodium cocoamphoacetate and alkyl glucoside, the ratio of sodium cocoamphoacetate to alkyl glucoside. For 3: Γΐ: 3. The sodium cocoamphoacetate is a colorless to slightly yellow transparent viscous liquid, and the commercial product has an active content of 30%, a viscosity of 5000-10000 at 25 ° C, and a sodium chloride content of less than 9 0%, 1% aqueous solution has a pH of 6. 0~8. 0, and its structural formula is RN (CH2C00Na) ₂ , the coconut oil-based amphoteric sodium acetate has low irritation, is particularly mild to the skin and eyes, and an anionic surface. The active agent can significantly reduce the irritation, and has good foaming power. The foam is rich and fine, and the skin feel is good, which can significantly improve the foam state of the formulation system. The alkyl glucoside comprises lauryl glucoside, coco glucoside, decyl glucoside, and octyl/decyl glucoside, preferably decyl glucoside, which is a pale yellow turbid viscous liquid, which is commercially available. 5, 25, 25, 5, 25, 5, 25 Under the condition of °C, the viscosity is 1000-6000. The mercaptoglucoside is derived from nature and has excellent mild cleansing ability to improve the foaming properties of shampoo. Increase the amount of foam and foam stability. The combination of sodium cocoamphoacetate and decyl glucoside has good foam and skin compatibility, minimizing irritation. The cationic composition of the present invention comprises from 0.05% to 3.0% by weight of the composition of the cationic polymer, the cationic polymer being selected from the group consisting of: at least one of a cationic cellulose polymer and a cationic guar polymer. Kind of cationic guar gum is preferred. The cationic guar gum is a product obtained by quaternizing guar gum, and the main component thereof is guar gum propyltrimethylammonium chloride, and a series of cationic guar gum can be obtained according to the degree of substitution. The product has a preferred degree of substitution of from 0.1 to 0.2, a nitrogen content of from 1. 3-1. 7%, of the cationic guar gum used in the present invention at 25 ° C, 1 ° /. The viscosity of the aqueous solution is from 3500 mPa·s to 4500 mPa·s; the cationic cellulose polymer is a copolymer of hydroxyethyl cellulose and alkyltrimethyl ammonium chloride, which can be classified according to the degree of cationic substitution: There are three types of high cationic substitution degree JR, medium cationic substitution degree LR and low cationic substitution degree LK, and cationic cellulose having a degree of cationic substitution is preferred. The shampoo compositions of the present invention may also contain other optional ingredients including pearlizing agents, viscosity modifiers, chelating agents, pH adjusting agents, preservatives, colors, flavors and the like. The pearlescent agent comprises from 0. 05% to 3.0% by weight of the composition, and non-limiting examples of the pearlizing agent are: ethylene glycol stearic acid monoester and ethylene glycol stearic acid diester, single hard Fatty acid and propylene glycol palmitate and glycerides, magnesium stearate amide, magnesium stearate, finely divided zinc oxide and titanium dioxide, preferably ethylene glycol stearate. The viscosity adjusting agent comprises 0.1% to 5.0% by weight of the composition, and non-limiting examples of the viscosity adjusting agent are: sodium chloride, ammonium chloride, monoethanolamine chloride, sodium sulfate, ammonium phosphate , hydroxyethyl cellulose, hydroxypropyl cellulose, acrylic acid and long-chain alkyl methacrylate copolymer, acrylate/stearyl ether-20/mercapto acrylate copolymer, decyl glucoside polyoxyethylene Ether (120) dioleate and the like. 01%至至重量。 The chelating agent by weight of the composition of 0.01% to 0. 30%, non-limiting examples of the chelating agent are: ethylenediaminetetraacetic acid, disodium edetate, trisodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, etc., preferably ethylene至5. 5至6. 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 The selection of the preservatives, flavors and pigments meets the requirements of cosmetic hygiene standards and uses safe raw materials. The shampoo compositions of the present invention are supplemented with water to the required amount in addition to the components described above. Preparation

The shampoo compositions of the present invention can be prepared by any of the known or otherwise effective techniques suitable for providing shampoo compositions. The methods of preparing the shampoo compositions of the present invention include conventional formulation and mixing techniques.

Instructions

The shampoo compositions of the present invention are used in a conventional manner for cleansing and conditioning hair, and include the following steps:

(A) moisturizing the hair with water;

(B) applying to the hair an effective amount of the shampoo composition of any of the preceding claims, the effective dose generally ranging from 1 gram to 50 grams, preferably from 2 to 20 grams;

(C) rinsing the shampoo composition on the hair with water.

These steps can be repeated as many times as needed to achieve the cleansing, conditioning, moisturizing and moisturizing properties sought.

Example

The following are non-limiting examples of shampoo compositions of the present invention. The examples are given for illustrative purposes only and are not to be construed as limiting the invention, as Many modifications of the invention are possible on the basis of the scope. In these examples, all concentrations are by weight unless otherwise stated. The term "minor matter" refers to those substances which are optional, such as preservatives, viscosity modifiers, pH adjusters, perfumes, pigments, etc. These small amounts of materials will be selected

PREPARATION EXAMPLE I - X Suitable methods for preparing the shampoo compositions of Examples I-X are as follows: Add an appropriate amount of water to the reaction tank, add guar gum for dispersion under slow agitation, and heat to 60 with slow agitation. From °C to 80 ° C, add an appropriate amount of citric acid to neutralize. Next, add ammonium lauryl sulfate, ammonium laureth sulfate, sodium cocoamphoacetate, decyl glucoside, ethylene glycol stearate, disodium edetate (if these substances are used) After completely dissolving and dissolving these substances, keep them warm for 30 minutes and start to cool down. When the temperature drops to 5 (about TC, add anti-debonding active, sodium chloride, citric acid, preservative, pigment, flavor, etc., continue to stir, to ensure a mixture of all the hooks. After adding all the components, according to It is necessary to add a viscosity modifier and a pH adjuster to adjust the viscosity and pH of the product to a suitable extent. Optionally, a small amount of water can be added to make up. Example I -V Weight (%)

Component

I II III IV V ammonium lauryl sulfate ( 70% ) 8. 0 8. 0 8. 0 8. 0 8. 0 Lauryl alcohol polyoxyethylene ether ammonium sulfate (70%) 10. 0 10. 0 12. 0 12. 0 12. 0 Sodium acetylate acetate 3. 0 4. 0 4. 5 5. 0 6. 0 decyl glucoside 6. 0 5. 5 5. 0 4. 5 4. 0 guar gum 0. 3 0. 3 0. 3 1. 3 1. 2 Anti-desorption compound active 5. 0 5. 0 6. 0 6. 0 7. 0 ethylene glycol stearate diester 1. 2 1. 2 1. 2 1. 2 1. 2 Disodium edetate 0. 1 0. 1 0. 1 0. 1 0. 1 citric acid, preservatives, colorants, perfumes, chlorine

Moderate amount

Sodium

Water added to 100%

Example VI-X

The preferred embodiment of the invention is: Component content % by weight ammonium lauryl ammonium sulfate (70%) 10. 0 Lauryl alcohol polyoxyethylene ether ammonium sulfate (70%) 12. 0 Cocoamphos sodium acetate 3. 0 Mercaptoglucoside 5.0 guar 0.3 anti-decomplex active 8

Glycol stearate diester 1.2

Disodium edetate 0.1 citric acid, preservative, colorant, perfume, sodium chloride, water, 100%. The components and contents (weight ratio) of the anti-debonding active in Example I-X are: Contains 23% ginseng essence, 4% hydrolyzed soy protein, 16% amino acid mixture (arginine: acetyl tyrosine: citrulline: ornithine hydrochloride = 1: 1 : 1 : 1), 7.5% vitamin Group B mixture (vitamin B3: vitamin B5: vitamin H = l : 1 : 1 ), 6% glucosamine hydrochloride, 2.5% zinc gluconate, 4% May burdock root extract and 2% PEG-12 diterpenoid Base silicone oil and 1.5% polyquaternium - 11 and the balance of water. Sensory physical and chemical indicators Item Test data Appearance Milky white pearlescent liquid

pH 5.5 fly.5 foam 100-170 legs viscosity 5000~10000mpa - s

( ⁴⁰ ± 1) °C for 4 weeks, return to room heat stability, qualitative

No separation after temperature

- 2 ° C - - 5 ° C for 4 weeks, return to room Cold resistance

After the temperature, there is no separation and water precipitation. The health indicators are all qualified. Anti-hair loss effect

Test Method: Forty volunteers with hair loss who were allergic, no wounds, and no systemic local disease were selected. The ratio of growth period and rest period of the patient's hair was lower than normal. Before the trial, the patient was evaluated for sensory and hair images, and the patient was treated with the best embodiment of the shampoo, for 112 days, and for sensory evaluation and hair image evaluation on days 56 and 112. During the trial, volunteers used the shampoo at the usual frequency of shampooing, requiring the shampoo to stay on the hair for 3-5 minutes and perform a gentle scalp massage before rinsing with warm water. For the sensory evaluation of the hair before and after the use of the shampoo, see Table 1, Table 2 and hair image evaluation are shown in Table 3:

Table 1

table 3

Forehead head head total In the first 56 days of the growing season 30% 60% 140% 80% Growth rate 112 days 110% 95% 170% 120%

Claims

Rights request

A shampoo composition comprising a high-efficiency anti-debinding agent, which, in addition to water, contains:

(A) an anionic surfactant in an amount of from 0.5% to 40% by weight of the composition;

(B) The weight of the composition is 1. 0 ° /. a composition of up to 10.0% of sodium cocoamphoacetate and an alkyl glucoside;

(C) 0.001% to 10% by weight of the composition of the anti-de-complexing active, the anti-de-complexing active is composed of the following components:

Ginseng essence of 10-25% by weight of the composite active substance;

Hydrolyzed soy protein comprising 1-5% by weight of the composite active;

a mixture of vitamin B groups of 3-10% by weight of the composite active substance, the vitamin B group mixture is vitamin B3: vitamin B5: vitamin H is mixed at a weight ratio of 1: 1:1;

5-10% by weight of the complex active glucosamine hydrochloride;

Zinc gluconate, 1-5% by weight of the composite active;

May burdock root extract, 1-5% by weight of the composite active;

PEG- 12 dimercaptosilicone oil, 1-5% by weight of the composite active;

Polyquaternium-11 of 1-5% by weight of the composite active;

And the balance of water;

(D) The cationic polymer in an amount of from 0. 05% to 3. 0% by weight of the composition.

2. The shampoo composition according to claim 1, wherein the anionic surfactant is selected from the group consisting of: mercaptosulfate, alkyl polyoxyethylene ether sulfate, fatty acid monoglyceride sulfate, alkylsulfonic acid Salt, N-acyl At least one of sarcosinate, N-glutamic acid salt, and alkyl phosphate salt.

3. The shampoo composition according to claim 1, wherein the ratio of sodium cocoamphoacetate to pit-based glucoside is from 3:1 to 1:3.

4. The shampoo composition of claim 1 wherein the cationic polymer is selected from the group consisting of: a cationic cellulose polymer or a cationic guar polymer.