WO2010079630A1

WO2010079630A1 - Analyzer

Info

Publication number: WO2010079630A1
Application number: PCT/JP2009/055507
Authority: WO
Inventors: 修野澤
Original assignee: オリンパス株式会社
Priority date: 2009-01-09
Filing date: 2009-03-19
Publication date: 2010-07-15
Also published as: JP2010160103A

Abstract

Provided is an analyzer which can perform analysis of a reagent blank by using an optimal blank sample for each item of analysis without increasing the time being spent for analysis of a reagent blank. The analyzer comprises a blank sample information storage section (35a) for storing correspondence information between an item of analysis and the kind of a blank sample to be used for analysis of a reagent blank, an acquisition section (36) for acquiring the kind of a blank sample in a second sample container (12a) held at a sample holding section (12) from information in a holding position information storage section (35b) and a detection result from a section (20) for detecting the presence/absence of a container, an extraction section (37) for extracting an item of analysis conforming to the kind thus acquired, a collation section (38) for collating the extracted item of analysis with an item of analysis received at an input section (32), a determination section (39) for determining the order of analysis of a reagent blank according to each item of analysis for an item of analysis matched by the collating such that analyses using the same kind of blank sample are sequenced, and a control section (31) performing control for executing analysis of reagent blank according to the order of analysis thus determined.

Description

Analysis equipment

The present invention relates to an analyzer for analyzing a sample by mixing a sample and a reagent of a type corresponding to the analysis item of the sample, and measuring the absorbance of the mixed solution of the sample and the reagent.

Conventionally, in an analyzer that analyzes a sample by measuring the absorbance of a mixed solution of the sample and the reagent, a reagent blank analysis is performed every predetermined period and a blank sample (when the target component concentration in the sample is 0) Analyze the sample by determining the absorbance (reagent blank value) at the measurement wavelength of the sample and reagent mixture, and using this reagent blank value as a correction value to set the calibration curve used to calculate the absorbance of the sample and reagent mixture Analysis accuracy is maintained.

For example, Patent Document 1 below describes an analyzer that automatically performs a reagent blank analysis at an arbitrarily determined time. In this analyzer, reagent blank analysis is performed by using one type of blank sample.

JP 59-182347 A

By the way, in the reagent blank analysis, different calibration curves may be created depending on the type of blank sample. In such a case, in the analysis item, what kind of blank sample is used to perform the reagent blank analysis is important. For example, in the analysis of albumin (ALB), it is more suitable to use physiological saline than ion-exchanged water as a blank sample used for reagent blank analysis.

However, in order to perform reagent blank analysis using the optimal type of blank sample for each analysis item, it is necessary to prepare multiple types of blank samples and perform analysis while changing the blank sample for each analysis item. There was a problem that the time spent for reagent blank analysis would increase.

The present invention has been made in view of the above, and provides an analyzer capable of performing a reagent blank analysis using an optimal blank sample for each analysis item without increasing the time spent for reagent blank analysis. The purpose is to do.

In order to solve the above-described problems and achieve the object, an analyzer according to the present invention mixes a sample and a reagent of a type corresponding to an analysis item of the sample, and provides a mixture of the sample and the reagent. In an analyzer for analyzing the sample by measuring absorbance, blank sample information storage for storing blank sample information in which the analysis item is associated with a type of blank sample to be used for reagent blank analysis of the analysis item Each of the plurality of sample containers held by the holding means, holding means for receiving the analysis items to be subjected to the reagent blank analysis, holding means for holding the plurality of sample containers in which the blank samples are accommodated, and Acquisition means for acquiring the type of the blank sample accommodated by the apparatus, and analysis items suitable for the type of blank sample acquired by the acquisition means. Extraction means for extracting based on the sample information, collation means for collating the analysis item extracted by the extraction means and the analysis item accepted by the acceptance means, and analysis items matched by the collation of the collation means, Reagent blank analysis according to each analysis item is determined according to the analysis order determined by the determination means for determining the analysis order of the reagent blank analysis so that at least the analysis items using the same type of blank sample are continuous. And a control means for performing control.

In order to solve the above-described problems and achieve the object, an analyzer according to the present invention mixes a sample and a reagent of a type corresponding to the analysis item of the sample, and provides a mixture of the sample and the reagent. In the analyzer for analyzing the sample by measuring absorbance, blank sample information storage for storing blank sample information in which the analysis item is associated with the type of blank sample to be used for the reagent blank analysis of the analysis item Each of the plurality of sample containers held by the holding means, holding means for receiving an analysis item to be subjected to reagent blank analysis, holding means for holding a plurality of sample containers in which the blank sample is accommodated, and Acquiring means for acquiring the type of the blank sample accommodated by the apparatus, and the type of blank sample suitable for the analysis item received by the receiving means. Extraction means for extracting based on rank sample information, collation means for collating the type of blank sample extracted by the extraction means with the type of blank sample obtained by the acquisition means, and a blank matched by the collation of the collation means Determination means for determining the analysis order of the reagent blanks corresponding to each analysis item with respect to the analysis items suitable for the type of sample so that the analysis items using at least the same type of blank sample are continuous, and the determination means Control means for performing control to execute reagent blank analysis in accordance with the determined analysis order.

Further, in the analysis apparatus according to the present invention, in the above invention, the acquisition unit stores holding position information that associates the type of the blank sample with the holding position of the sample container determined for each type of the blank sample. A holding position information storing means; and a detecting means for detecting the presence or absence of the sample container at the holding position, and using the holding position information stored in the holding position information storing means and the result detected by the detecting means. Thus, the type of the blank sample stored in each of the plurality of sample containers held by the holding means is obtained.

Moreover, the analyzer according to the present invention outputs information in which the type of the blank sample and the holding position are associated with each other based on the holding position information stored in the holding position information storage means in the above invention. An output means is provided.

Moreover, in the analysis apparatus according to the present invention, in the above invention, the blank sample information storage unit stores the amount of the blank sample used as the blank sample information together with the type of the blank sample for each analysis item, and the reception unit Comprises calculating means for calculating the amount used for each type of blank sample necessary for the reagent blank analysis according to the analysis item received based on the blank sample information stored in the blank sample information storage means, and the output means The use amount for each type of the blank sample calculated by the calculation means is output.

In the analysis apparatus according to the present invention, in the above invention, the acquisition unit is provided in the sample container, and the identification unit is configured to record the identification information for identifying the type of the blank sample in the sample container. The type of the blank sample is acquired by reading information.

According to this invention, the blank sample information storage means for storing the blank sample information in which the analysis item of the sample and the type of the blank sample to be used for the reagent blank analysis of the analysis item are associated, and the target of the reagent blank analysis Each of the plurality of sample containers held by the holding means accommodates an analysis apparatus including a receiving means for receiving the analysis item and a holding means for holding the plurality of sample containers in which the blank samples are accommodated. The type of the blank sample is acquired, the analysis item that matches the type of the acquired blank sample is extracted based on the blank sample information, the extracted analysis item and the analysis item received by the reception unit are verified, and verification is performed. For analysis items that match each other, use at least the same type of blank sample in the reagent blank analysis order according to each analysis item. Since the analysis blanks are determined to be continuous and the reagent blank analysis is controlled in accordance with the determined analysis order, the optimal blank sample can be selected for each analysis item without increasing the time spent on the reagent blank analysis. The used reagent blank analysis can be performed.

FIG. 1 is a schematic diagram showing the configuration of the analyzer according to the first embodiment of the present invention. FIG. 2 is a diagram showing blank sample information stored in the blank sample information storage unit shown in FIG. FIG. 3 is a diagram showing the holding position information stored in the holding position information storage unit shown in FIG. FIG. 4 is a flowchart showing the procedure of the reagent blank analysis process by the analyzer shown in FIG. FIG. 5 is a diagram showing a reception menu screen output by the output unit shown in FIG. FIG. 6 is a diagram illustrating a holding position information screen output by the output unit illustrated in FIG. FIG. 7 is a diagram illustrating analysis items extracted by the extraction unit illustrated in FIG. 1. FIG. 8 is a diagram illustrating analysis items that are matched by the collation performed by the collation unit illustrated in FIG. 1. FIG. 9 is a schematic diagram showing the configuration of the analyzer according to the second embodiment of the present invention. FIG. 10 is a flowchart showing the procedure of the reagent blank analysis process by the analyzer shown in FIG. FIG. 11 is a diagram showing types of blank samples extracted by the extraction unit shown in FIG. FIG. 12 is a diagram showing a usage amount display screen output by the output unit shown in FIG. FIG. 13 is a diagram illustrating types of blank samples that are matched by collation performed by the collation unit illustrated in FIG. 9. FIG. 14 is a schematic diagram showing the configuration of the analyzer according to the third embodiment of the present invention. FIG. 15 is a flowchart showing a procedure of reagent blank analysis processing by the analyzer shown in FIG. FIG. 16 is a diagram showing information in which the code number recorded on the sample container identification label shown in FIG. 14 is associated with the type of blank sample.

Explanation of symbols

1, 2, 3

Analyzer

10, 60 Measuring unit 11 Sample supply unit 11a First sample vessel 11b Rack 11c Reaction vessel 11f Sample vessel identification label 12 Sample holder 12a Second sample vessel 13 Reaction tank 13a Wheel 14 Reagent chamber 14a Reagent Container 15

Sample dispensing mechanism

15a, 16a Nozzle 15b, 16b Arm 16 Reagent dispensing mechanism 17 Stirring unit 18 Photometric unit 19 Washing unit 20 Container presence /

absence detecting unit

30, 50, 70

Control unit

31, 51, 71 Control unit 32 Input unit 33 Analyzing unit 34

Output unit

35, 52, 72

Storage unit

35a, 52a Blank sample information storage unit 35b Holding position

information storage unit

36, 73 Acquisition unit 37, 53 Extraction unit 38, 54

Verification unit

39, 55 Determination unit 56 Calculation unit P ₁ to P _n , p ₁ to p ₅ positions

Hereinafter, preferred embodiments of an analyzer according to the present invention will be described in detail with reference to the drawings. The present invention is not limited to the embodiments.
(Embodiment 1)

FIG. 1 is a schematic diagram showing the configuration of the analyzer according to the first embodiment of the present invention. As shown in FIG. 1, the analysis device 1 includes a measurement unit 10 and a control device 30. The measurement unit 10 dispenses a sample such as a specimen and a reagent into the reaction container 11c, and optically measures the reaction occurring in the reaction container 11c. The control device 30 controls the entire analyzer 1 including the measurement unit 10 and analyzes measurement data in the measurement unit 10. The analysis apparatus 1 automatically performs biochemical analysis of a plurality of samples sequentially in cooperation with each other.

The measurement unit 10 includes a sample supply unit 11, a sample holding unit 12, a reaction tank 13, a reagent storage 14, a sample dispensing mechanism 15, a reagent dispensing mechanism 16, a stirring unit 17, a photometric unit 18, a washing unit 19, and a container presence / absence A detection unit 20 is included.

The sample supply unit 11 transports the first sample container 11a to the sample suction position by transporting the rack 11b holding the first sample container 11a containing a sample such as a general specimen. The sample in the first sample container 11a conveyed to the sample suction position is dispensed by the sample dispensing mechanism 15 into the reaction container 11c conveyed to the sample dispensing position.

The sample holder 12 is a second sample container 12a that accommodates various samples (blank samples, emergency samples, etc.) other than general samples at holding positions P _v (v = 1,..., N,..., 30: n is a natural number). Has a concave accommodating portion. The sample holding unit 12 can be rotated clockwise or counterclockwise about a vertical line passing through the center of the sample holding unit 12 as a rotation axis by driving a driving mechanism (not shown) under the control of the control device 30. Yes, the predetermined second sample container 12a is transferred to the sample suction position by the sample dispensing mechanism 15. In addition, although the sample holding | maintenance part 12 illustrated what has 30 accommodating parts, it should just have not only this but a several accommodating part.

The reaction tank 13 has a heat insulating member (not shown) and a wheel 13a. The wheel 13a holds a plurality of reaction vessels 11c and rotates by a drive mechanism (not shown) to transfer the reaction vessels 11c in the circumferential direction. The reaction tank 13 is covered with a disk-shaped lid (not shown), and a heat insulation tank that keeps the internal temperature at a human body temperature is provided along with a heat insulation member (not shown) disposed on the inside and outside in the radial direction of the wheel 13a. It is composed.

The reagent storage 14 detachably stores a plurality of reagent containers 14a in which reagents to be dispensed in the reaction container 11c are stored. The reagent storage 14 can be rotated clockwise or counterclockwise about a vertical line passing through the center of the reagent storage 14 as a rotation axis by driving a drive mechanism (not shown) under the control of the control device 30. The predetermined reagent container 14a is transferred to the reagent suction position by the reagent dispensing mechanism 16.

The sample dispensing mechanism 15 has an arm 15b to which a nozzle 15a for sucking and discharging a sample is attached at the tip. The arm 15b freely moves up and down in the vertical direction and rotates around a vertical line passing through its base end as a central axis. The sample dispensing mechanism 15 has an intake / exhaust mechanism using an intake / exhaust syringe or a piezoelectric element. The sample dispensing mechanism 15 sucks the sample from the first sample container 11a transferred to the sample suction position of the sample supply unit 11 by the nozzle 15a, rotates the arm 15b counterclockwise in the drawing, The sample is discharged into the reaction container 11c conveyed to the sample discharge position.

The reagent dispensing mechanism 16 has an arm 16b to which a nozzle 16a for sucking and discharging the reagent is attached to the tip. The arm 16b freely moves up and down in the vertical direction and rotates around the vertical line passing through its base end as a central axis. The reagent dispensing mechanism 16 has an intake / exhaust mechanism using an unillustrated intake / exhaust syringe or piezoelectric element. The reagent dispensing mechanism 16 sucks the reagent in the reagent container 14a transferred to a predetermined position on the reagent storage 14 by the nozzle 16a, rotates the arm 16b clockwise in the drawing, and moves the arm 16b to the predetermined position on the reaction tank 13. The reagent is discharged into the transported reaction container 11c.

The stirring unit 17 stirs the mixed solution of the reagent and the sample dispensed in the reaction vessel 11c to promote the reaction between the sample and the reagent.

The photometry unit 18 irradiates the reaction vessel 11c, which has been transferred to a predetermined measurement position, with measurement light from the light source 18a, disperses the light transmitted through the mixture of the sample and the reagent in the reaction vessel 11c, and uses the light receiving element 18b. By measuring the intensity of each wavelength light, the absorbance at a wavelength peculiar to the mixed solution of the sample to be analyzed and the reagent is measured.

The cleaning unit 19 performs cleaning by sucking and discharging the mixed solution in the reaction vessel 11c that has been measured by the photometry unit 18 by using a nozzle (not shown) and injecting and sucking cleaning liquid such as detergent and cleaning water. .

The container presence / absence detection unit 20 is disposed in the vicinity of the sample holding unit 12. The container presence / absence detection unit 20 detects the presence / absence of the second sample container 12a at the holding position _Pv as detection means. The container presence / absence detection unit 20 is realized by, for example, an optical sensor that optically detects the presence / absence of the second sample container 12a. The container presence / absence detection unit 20 outputs a detection signal to the control device 30 when detecting the second sample container 12a.

The control device 30 includes a control unit 31, an input unit 32, an analysis unit 33, an output unit 34, a storage unit 35, an acquisition unit 36, an extraction unit 37, a collation unit 38, and a determination unit 39. The control unit 31 is realized by a CPU or the like, and controls processing and operation of each unit of the analyzer 1. The control unit 31 performs predetermined input / output control on information input / output to / from each of these components, and performs predetermined information processing on this information.

The input unit 32 is realized by a keyboard, a mouse, or the like, and can input various information such as the number of samples or analysis items. The input unit 32 receives input of analysis items corresponding to reagent blank analysis as receiving means.

The analysis unit 33 obtains the concentration of the detection target in the sample based on the measurement result measured by the photometry unit 18, and performs component analysis of the sample. The output unit 34 is realized by a display panel, a printer, or the like, and outputs various types of information such as sample analysis data and alarms as output means. The output unit 34 can output information that assists the input of analysis items corresponding to the reagent blank analysis by the input unit 32.

The storage unit 35 includes a blank sample information storage unit 35a and a holding position information storage unit 35b. The blank sample information storage unit 35a stores, as blank sample information storage means, blank sample information in which sample analysis items are associated with types of blank samples to be used for reagent blank analysis of the analysis items. FIG. 2 shows, for each analysis item A _i (i = 1,..., M: m is a natural number), a blank sample type B _j (j = 1,..., N: to be used for the reagent blank analysis of the analysis item A _i. FIG. 11 is a diagram showing a blank sample information table 35a-1 in which n is a natural number). In the blank sample information table 35a-1, for example, indicates that the blank sample type B ₁ is, it is associated as blank sample to be used for the reagent blank analysis of analysis items A _1.

The holding position information storage unit 35b stores, as holding position information storage means, holding position information that associates the type of blank sample with the holding position of the second sample container 12a determined for each type. Figure 3 is a diagram showing a holding position P ₁ ~ P _n, the holding position P ₁ ~ type B ₁ ~ holding position information table 35b-1 that the B _n in correspondence of the blank sample to be retained in the P _n . Holding position information table 35b-1, for example, indicates that it should retain the blank sample type B ₁ in the holding position P _1. In addition, although the example which the position which hold | maintains a blank sample adjoins continuously was illustrated, it is not restricted to this, What is necessary is just to be able to hold | maintain a several blank sample in the holding position predetermined for every kind of blank sample. For example, the blank sample may be held at the holding position P _1, and the blank sample may be held at the holding position P ₃ without holding the blank sample at the holding position P ₂ .

The storage unit 35 includes a hard disk that magnetically stores information, and a memory that electrically reads various programs related to this process from the hard disk when the analyzer 1 executes the process. The storage unit 35 stores analysis data of the sample including the absorbance and the like that have been subjected to arithmetic processing.

The acquisition unit 36 acquires the type of blank sample accommodated in each of the plurality of second sample containers 12a held by the sample holding unit 12 as an acquisition unit. The acquisition unit 36 uses each of the plurality of second sample containers 12a held by the sample holding unit 12 by using the holding position information stored in the holding position information storage unit 35b and the result detected by the container presence / absence detection unit 20. The type of the blank sample accommodated by is acquired.

The extraction unit 37 extracts analysis items that match the type of blank sample acquired by the acquisition unit 36 based on the blank sample information stored in the blank sample information storage unit 35a.

The collation unit 38 collates the analysis item extracted by the extraction unit 37 and the analysis item received by the input unit 32.

The determination unit 39 determines the analysis order of the reagent blank analysis corresponding to each analysis item for the analysis items matched by the verification of the verification unit 38 so that the analysis items using at least the same type of blank sample are continuous. .

In the analyzer 1 configured as described above, the reagent dispensing mechanism 16 dispenses a reagent from the reagent container 14a to the reaction container 11c with respect to the plurality of reaction containers 11c that are sequentially transported, and the sample dispensing mechanism. 15 dispenses a predetermined amount of sample from the first sample container 11a to the reaction container 11c. Subsequently, after the stirring unit 17 stirs and reacts the reagent and the sample in the reaction vessel 11c, the photometry unit 18 measures the absorbance of the mixed solution of the reagent and the sample. Thereafter, the analysis unit 33 performs an operation for analyzing the measurement result of the photometry unit 18 and automatically performs a component analysis of the sample. In addition, the cleaning unit 19 cleans and dries the reaction vessel 11 c that has been measured by the photometry unit 18.

Next, the reagent blank analysis process performed by the analyzer 1 will be described with reference to the flowchart shown in FIG. First, the analyzer 1 determines whether or not an analysis item corresponding to the reagent blank analysis is received (step S101). The reception of the analysis item corresponding to the reagent blank analysis is performed via the input unit 32 using the reception menu screen output by the output unit 34, for example.

FIG. 5 is a display example of a reception menu screen for receiving an analysis item corresponding to the reagent blank analysis output by the output unit 34. Operator selects a reception menu analysis item A ₁ ~ A predetermined analysis item from _m on the screen 34a through the input unit 32, by registering, receiving the analysis item corresponding to the reagent blank analysis is performed . For example, when registering analysis items A ₁ , A ₃ , and A ₄ , the operator selects each analysis item button 34 a-3, 34 a-4, 34 a-5 on the reception menu screen 34 a via a mouse or the like. After that, the analysis items A ₁ , A ₃ , A ₄ are accepted by selecting the registration button 34a-1. Here, the case where the analysis item is received using the reception menu screen 34a output by the output unit 34 is illustrated, but the code assigned to each analysis item may be input via the keyboard. Good.

When an analysis item corresponding to the reagent blank analysis is received in step S101 (step S101: Yes), the output unit 34 outputs a holding position information screen (step S102). FIG. 6 is a display example of a holding position information screen that the output unit 34 outputs to the display panel based on the holding position information stored in the holding position information storage unit 35b. The holding position information screen 34b shown in the figure is output, for example, by selecting the holding position button 34a-2 on the reception menu screen 34a. Holding position information screen 34b is a holding position P _1, it indicates that it should retain the blank sample type B _1. Since the type of blank sample to be held for each holding position is determined in advance, the holding position information screen 34b need not be output. On the other hand, when the analysis item corresponding to the reagent blank analysis is not received in step S101 (step S101: No), the control unit 31 repeats this determination process.

After the output unit 34 outputs the holding position information screen in step S102, the control unit 31 determines whether or not the setting of the second sample container 12a to the sample holding unit 12 is completed (step S103). The determination in step S103 is performed based on, for example, whether or not a signal indicating completion of setting, that is, a signal indicating that reagent blank analysis is started is output from the input unit 32 to the control unit 31.

When the setting of the second sample container 12a to the sample holding unit 12 is completed in step S103 (step S103: Yes), the container presence / absence detection unit 20 performs the second operation at the holding positions P ₁ to P _n where the blank sample is held. The presence or absence of the sample container 12a is detected (step S104). This detection is performed while the sample holder 12 makes a round clockwise or counterclockwise with a vertical line passing through the center of the sample holder 12 as a rotation axis. On the other hand, when the setting of the second sample container 12a to the sample holding unit 12 is not completed (step S103: No), the output unit 34 repeats this determination process.

After detecting the presence or absence of the second sample container 12a at the holding positions P ₁ to P _n in step S104, the acquiring unit 36 acquires the type of blank sample in the second sample container 12a held by the sample holding unit 12. (Step S105). Specifically, the acquisition unit 36 obtains the holding position information of the second sample container 12a determined for each type of blank sample stored in the holding position information storage unit 35b and the result detected by the container presence / absence detection unit 20. By using it, the type of the blank sample is acquired. For example, as when the container presence detector 20 detects that the second sample container 12a is in the holding position P _1, the blank sample B ₁ corresponding to the holding position P ₁ is accommodated in the second sample vessel 12a To do.

Then, the extraction part 37 extracts the analysis item suitable for the kind of blank sample which the acquisition part 36 acquired (step S106). The analysis item is extracted based on the blank sample information stored in the blank sample information storage unit 35a. FIG. 7 is a diagram illustrating an example of analysis items extracted by the extraction unit 37. FIG. 7 shows a case where the acquisition unit 36 acquires the types B ₁ and B ₂ of the blank sample. The extraction unit 37 extracts the analysis item A ₁ as an analysis item suitable for the type B ₁ blank sample, and extracts the analysis items A ₂ to A ₅ as analysis items suitable for the type B ₂ blank sample.

Thereafter, the collation unit 38 collates the analysis item extracted by the extraction unit 37 with the analysis item received by the input unit 32 (hereinafter referred to as reception analysis item) (step S107). FIG. 8 is a diagram showing analysis items matched by collation by the collation unit 38 among the analysis items A ₁ to A ₅ extracted by the extraction unit 37 shown in FIG. Figure 8 is accepted analysis items in step S101 shows the case of A _1, A ₃ and A _4, analysis item A _1, A ₃ and that meet in the analysis item A ₁ ~ A ₅ shown in FIG. 7 and a _4, showing the correspondence between the type of the obtained blank sample.

Thereafter, the control unit 31 determines whether or not it is possible to perform all of the reagent blank analysis of the received analysis items (step S108). This determination is made based on whether or not all the reagent blank analyzes of the received analysis items can be performed when the reagent blank analysis of the analysis items matched by the verification of the verification unit 38 is performed.

When it is possible to perform all the reagent blank analysis of the received analysis items (step S108: Yes), the determination unit 39 performs the reagent blank analysis corresponding to each analysis item with respect to the analysis item matched by the collation of the collation unit 38. The analysis order is determined (step S109). This analysis order is determined so that analysis items using the same type of blank sample are continuous. As shown in FIG. 8, analysis item using the blank sample type B ₂ be a A ₃ and A _4, the reagent blank analysis of analysis items A ₃ and A ₄ determines the analysis order to continuously. On the other hand, when it is not possible to perform all the reagent blank analysis of the reception analysis item (step S108: No), the output unit 34 outputs abnormality information indicating that the reagent blank analysis process is abnormal (step S110). Then, the control part 31 complete | finishes this process.

After determining the analysis order of the reagent blank analysis of the reception analysis item in step S109, the control unit 31 causes the analyzer 1 to perform the reagent blank analysis of the reception analysis item according to the analysis order determined by the determination unit 39 (step S111). . Then, the control part 31 complete | finishes this process.

In Embodiment 1 of the present invention, a blank sample information storage unit 35a for storing blank sample information in which a sample analysis item is associated with a type of blank sample to be used for a reagent blank analysis of the analysis item, and a reagent blank analysis The sample holding unit 12 holds the analyzer 1 including an input unit 32 that receives an analysis item that is a target of the sample and a sample holding unit 12 that holds a plurality of second sample containers 12a in which blank samples are stored. The type of blank sample accommodated in each of the plurality of second sample containers 12a is acquired, analysis items that match the acquired type of blank sample are extracted based on the blank sample information, and the extracted analysis items and input unit 32 are provided. The analysis order received is collated, and the analysis order of the reagent blank analysis according to each analysis item is set to at least the analysis item matched by the collation. The analysis items that use different types of blank samples are determined to be continuous, and the reagent blank analysis is controlled according to the determined order of analysis, so there is no increase in the time spent on reagent blank analysis. Reagent blank analysis using an optimal blank sample can be performed.

In the first embodiment, the output unit 34 outputs information that associates the type of the blank sample with the holding position based on the holding position information stored in the holding position information storage unit 35b. The operator can reliably set the blank sample for each type in the sample holder 12.

(Embodiment 2)
Next, a second embodiment of the present invention will be described. FIG. 9 is a schematic diagram showing the configuration of the analyzer according to the second embodiment of the present invention. The analysis device 2 illustrated in FIG. 9 includes a measurement unit 10 and a control device 50. In addition, the same code | symbol is attached | subjected to the same component as Embodiment 1. FIG. The control unit 51 of the control device 50 includes an extraction unit 53, a collation unit 54, a determination unit 55, and a calculation unit 56. The storage unit 52 includes a blank sample information storage unit 52a.

The extraction unit 53 extracts the type of blank sample that matches the analysis item received by the input unit 32 (hereinafter referred to as reception analysis item) based on the blank sample information described above. The collation unit 54 collates the type of the blank sample extracted by the extraction unit 53 and the type of the blank sample acquired by the acquisition unit 36. For the analysis item that matches the type of the blank sample matched by the collation of the collation unit 54, the determination unit 55 sets the analysis order of the reagent blanks according to each analysis item to the analysis item that uses at least the same type of blank sample. Decide to be continuous. The calculation part 56 calculates the usage-amount for every kind of blank sample required for the reagent blank analysis according to a reception analysis item based on the blank sample information which the blank sample information storage part 52a memorize | stores. The blank sample information storage unit 52a stores the amount of the blank sample used together with the type of the blank sample for each analysis item as blank sample information.

Next, the reagent blank analysis process performed by the analyzer 2 will be described with reference to the flowchart shown in FIG. First, the analyzer 2 determines whether or not an analysis item corresponding to the reagent blank analysis is received (step S201). The analysis item corresponding to the reagent blank analysis is received via the input unit 32 using the reception menu screen 34a output to the display panel by the output unit 34, for example, as in the first embodiment.

When the analysis item corresponding to the reagent blank analysis is received in step S201 (step S201: Yes), the extraction unit 53 stores the blank sample type that matches the received analysis item in the blank sample information storage unit 52a. Extraction is performed based on the sample information (step S202). FIG. 11 is a diagram illustrating the types of blank samples extracted by the extraction unit 53. The case shown in FIG. 11, the extraction unit 53 extracts the type B ₁ as a blank sample type conforming to the acceptance analysis item A _1, type B ₂ as a blank kinds of samples conform to the accepted analysis item A ₃ and A ₄ To extract. On the other hand, when no analysis item corresponding to the reagent blank analysis is received in step S201 (step S201: No), the control unit 51 repeats this determination process.

After the blank sample type is extracted in step S202, the calculation unit 56 calculates the usage amount of each blank sample type necessary for the reagent blank analysis according to the received analysis item (step S203). The calculation of the usage amount is performed based on the usage amount of the blank sample that the blank sample information storage unit 52a stores together with the type of the blank sample. Thereafter, the output unit 34 outputs the usage amount of the blank sample calculated by the calculation unit 56 (step S204). FIG. 12 is a usage amount display screen 54a in which the usage amount calculated by the calculation unit 56 is further associated with the type of blank sample in association with the information that associates the type of blank sample with the holding positions P ₁ to P _n . The usage amount display screen 54a indicates that 10 μL of the type B ₁ blank sample should be held at the holding position P ₁ , and indicates that 20 μL of the type B ₂ blank sample should be held at the holding position P ₂ . Since the type of blank sample for each holding position is determined in advance, the output unit 34 may output only information in which the amount used corresponds to the type of blank sample.

After the output unit 34 outputs the usage amount of the blank sample in step S204, the control unit 51 determines whether or not the setting of the second sample container 12a to the sample holding unit 12 is completed (step S205). The determination as to whether or not the setting of the second sample container 12a to the sample holding unit 12 has been completed is, for example, a signal indicating the completion of setting, that is, a signal indicating the start of reagent blank analysis, as in the first embodiment. Is performed depending on whether or not is output from the input unit 32 to the control unit 51.

When the setting of the second sample container 12a to the sample holding unit 12 is completed in step S205 (step S205: Yes), the container presence / absence detection unit 20 performs the second operation at the holding positions P ₁ to P _n where the blank sample is held. The presence or absence of the sample container 12a is detected (step S206). This detection is performed while the sample holder 12 makes a round clockwise or counterclockwise with a vertical line passing through the center of the sample holder 12 as a rotation axis. On the other hand, when the setting of the second sample container 12a to the sample holding unit 12 is not completed (step S205: No), the output unit 34 repeats this determination process.

After detecting the presence or absence of the second sample container 12a at the holding positions P ₁ to P _n in step S206, the acquisition unit 36 acquires the type of blank sample in the second sample container 12a held by the sample holding unit 12. (Step S207). The acquisition unit 36 uses the holding position information of the second sample container 12a determined for each type of blank sample stored in the holding position information storage unit 35b and the result detected by the container presence / absence detection unit 20 to perform the second operation. The type of blank sample in the sample container 12a is acquired.

Thereafter, the collation unit 54 collates the type of the blank sample extracted by the extraction unit 53 with the type of the blank sample acquired by the acquisition unit 36 (Step S208). FIG. 13 is a diagram illustrating the types of blank samples that are matched by the collation by the collation unit 54. FIG. 13 shows a case where the acquisition unit 36 acquires only a blank sample of type B ₁ in step S207, which matches among the types of blank samples B ₁ and B ₂ shown in FIG. 11 extracted by the extraction unit 53. the type B ₁ of the blank sample, showing the correspondence between the reception analysis item.

Thereafter, the control unit 51 determines whether or not it is possible to perform all of the reagent blank analysis of the received analysis items (step S209). This determination is based on whether or not all the reagent blank analyzes of the reception analysis items can be performed when the reagent blank analysis of the analysis items matching the type of the blank sample matched by the verification of the verification unit 54 is performed. To be judged. When it is possible to perform all of the reagent blank analysis of the received analysis items (step S209: Yes), the determination unit 55 performs each analysis on the analysis item that matches the type of the blank sample matched by the collation of the collation unit 54. An analysis order of reagent blank analysis corresponding to the item is determined (step S210). This analysis order is determined so that analysis items using at least the same type of blank sample are continuous. On the other hand, when it is not possible to perform all the reagent blank analysis of the received analysis items (step S209: No), the output unit 34 outputs abnormality information indicating that the reagent blank analysis process is abnormal (step S211). Then, the control part 51 complete | finishes this process.

In step S211, after determining the analysis order of the reagent blank analysis of the reception analysis item, the control unit 51 causes the analyzer 2 to execute the reagent blank analysis of the reception analysis item according to the analysis order determined by the determination unit 55 (step S212). ). Then, the control part 51 complete | finishes this process.

In Embodiment 2 of the present invention, the analysis device 2 acquires the type of blank sample stored in each of the plurality of second sample containers 12a held by the sample holding unit 12, and the analysis item received by the input unit 32 The blank sample type that conforms to the criteria is extracted based on the blank sample information, the extracted blank sample type is collated with the acquired blank sample type, , Because the reagent blank analysis order according to each analysis item is determined so that at least the analysis items using the same type of blank sample are continuous, and the reagent blank analysis is performed according to the determined analysis order, As in the first embodiment, a reagent using an optimal blank sample for each analysis item without increasing the time spent for reagent blank analysis It is possible to perform the rank analysis.

Moreover, in Embodiment 2, the calculation part 56 calculates based on the blank sample information which the blank sample information storage part 52a memorize | stores the usage-amount for every kind of blank sample required for the reagent blank analysis according to a reception analysis item. The output unit 34 outputs information in which the type of the blank sample is associated with the holding positions P ₁ to P _n and information in which the usage amount calculated by the calculation unit 56 is associated with the type of the blank sample. Therefore, the operator can reliably set the blank sample for each type in the sample holding unit 12 and can set the blank sample corresponding to the amount used.

The analysis apparatus 1 according to the first embodiment includes the calculation unit 56, and after the collation unit 38 collates the analysis item extracted by the extraction unit 37 with the received analysis item, the calculation unit 56 uses the reagent blank of the blank sample. The usage amount in the analysis may be calculated, and the output unit 34 may output the usage amount calculated by the calculation unit 56 according to the type of the blank sample.

(Embodiment 3)
Next, a third embodiment of the present invention will be described. FIG. 14 is a schematic diagram showing the configuration of the analyzer according to the third embodiment of the present invention. The analysis device 3 illustrated in FIG. 14 includes a measurement unit 60 and a control device 70. In addition, the same code | symbol is attached | subjected to the same component as Embodiment 1. FIG. The measurement unit 60 includes a sample container identification label reading unit 61, and the control unit 71 of the control device 70 includes a storage unit 72 and an acquisition unit 73 that do not include the holding position information storage unit 35b. Further, the blank sample is accommodated not in the second sample container 12a but in, for example, the first sample container 11a held in the rack 11b having _five holding positions p ₁ to p ₅ .

The sample container identification label reading unit 61 is disposed in the vicinity of the sample supply unit 11. The sample container identification label reading unit 61 is provided in the first sample container 11a, and reads and reads the identification information of the sample container identification label 11f in which the identification information for identifying the type of the blank sample in the first sample container 11a is recorded. The identification information is output to the control device 70. The sample container identification label 11f is realized by, for example, a barcode. The sample container identification label reading unit 61 may use, for example, an apparatus that reads an information recording medium on which information for identifying the type of specimen in the first sample container 11a is recorded.

The acquisition unit 73 accommodates each of the plurality of first sample containers 11a held by the rack 11b based on the identification information recorded on the sample container identification label 11f output to the control device 70 by the sample container identification label reading unit 61. The type of blank sample to be acquired is acquired.

Next, a reagent blank analysis process performed by the analyzer 3 will be described with reference to the flowchart shown in FIG. First, the analyzer 3 determines whether or not an analysis item corresponding to the reagent blank analysis is received (step S301). The analysis item corresponding to the reagent blank analysis is received through the input unit 32 using the reception menu screen 34a output to the display panel by the output unit 34, for example, as in the first and second embodiments.

When an analysis item corresponding to the reagent blank analysis is received in step S301 (step S301: Yes), the control unit 71 determines whether or not the setting of the rack 11b to the sample supply unit 11 is completed (step S302). ). The determination in step S302 is performed based on, for example, whether a signal indicating completion of setting, that is, a signal indicating that reagent blank analysis is started is output from the input unit 32 to the control unit 71. On the other hand, when the analysis item corresponding to the reagent blank analysis is not received in step S301 (step S301: No), the control unit 71 repeats this determination process.

When the setting of the rack 11b to the sample supply unit 11 is completed in step S302 (step S302: Yes), the sample container identification label reading unit 61 applies the first sample container 11a at the holding positions p ₁ to p ₅ of the rack 11b. The identification information of the provided sample container identification label 11f is read (step S303). This reading is performed while the rack 11 b is transported in the vicinity of the sample container identification label reading unit 61 by the sample supply unit 11. On the other hand, when the setting of the rack 11b to the sample supply unit 11 is not completed (step S302: No), the control unit 71 repeats this determination process.

After reading the identification information of the sample container identification label 11f provided in the first sample container 11a at the holding positions p ₁ to p ₅ in step S303, the acquisition unit 73 stores the inside of the first sample container 11a held in the rack 11b. The type of blank sample is acquired (step S304). FIG. 16 shows an information table 72-1 in which code numbers as identification information recorded on the sample container identification label 11f are associated with the types of blank samples. Using the information table 72-1 stored in the storage unit 72, the acquisition unit 73 acquires the type of blank sample in the first sample container 11a from the code number read by the sample container identification label reading unit 61.

Thereafter, the analysis device 3 performs the same processing as the processing of steps S106 to S111 performed by the analysis device 1 (steps S305 to S310).

In Embodiment 3 of the present invention, the analysis device 3 acquires the type of blank sample accommodated in each of the plurality of first sample containers 11a held by the rack 11b, and analyzes that match the acquired type of blank sample. The items are extracted based on the blank sample information, the extracted analysis items and the analysis items received by the input unit 32 are collated, and the analysis order of the reagent blank analysis corresponding to each analysis item is performed on the analysis items matched by the collation. Is determined so that at least analysis items using the same type of blank sample are continuous, and the reagent blank analysis is performed in accordance with the determined analysis order. Therefore, as in the first and second embodiments, the reagent It is possible to perform reagent blank analysis using an optimal blank sample for each analysis item without increasing the time spent for blank analysis. Rutotomoni, sample container identification label reader 61, so as to read each sample vessel identification label 11f the holding position p ₁ ~ p ₅ which records the code number identifying the blank type of sample in the first sample vessel 11a Therefore, even if the first sample container 11a is held at an arbitrary holding position in the rack 11b, the type of blank sample in the first sample container 11a can be acquired.

As described above, the analyzer according to the present invention is useful for a medical analyzer that automatically analyzes different analysis items for a specimen.

Claims

In an analyzer for analyzing a sample by mixing a sample and a reagent of a type corresponding to the analysis item of the sample, and measuring the absorbance of a mixed solution of the sample and the reagent,
Blank sample information storage means for storing blank sample information in which the analysis item is associated with the type of blank sample to be used for the reagent blank analysis of the analysis item;
Receiving means for receiving an analysis item to be subjected to reagent blank analysis;
Holding means for holding a plurality of sample containers in which the blank sample is stored;
Obtaining means for obtaining the type of the blank sample contained in each of the plurality of sample containers held by the holding means;
An extraction means for extracting an analysis item suitable for the type of blank sample acquired by the acquisition means based on the blank sample information;
Collating means for collating the analysis items extracted by the extracting means with the analysis items received by the accepting means;
Determination means for determining the analysis order of the reagent blank analysis according to each analysis item so that the analysis items using at least the same type of blank sample are continuous for the analysis items matched by the verification of the verification means;
Control means for performing control to execute reagent blank analysis according to the analysis order determined by the determination means;
An analyzer characterized by comprising:
In an analyzer for analyzing a sample by mixing a sample and a reagent of a type corresponding to the analysis item of the sample, and measuring the absorbance of a mixed solution of the sample and the reagent,
Blank sample information storage means for storing blank sample information in which the analysis item is associated with the type of blank sample to be used for the reagent blank analysis of the analysis item;
Receiving means for receiving an analysis item to be subjected to reagent blank analysis;
Holding means for holding a plurality of sample containers in which the blank sample is stored;
Obtaining means for obtaining the type of the blank sample contained in each of the plurality of sample containers held by the holding means;
An extraction means for extracting the type of blank sample suitable for the analysis item received by the reception means based on the blank sample information;
Collating means for collating the type of blank sample extracted by the extracting means and the type of blank sample acquired by the acquiring means;
For analysis items that match the type of blank sample matched by the verification of the verification means, the analysis order of reagent blanks according to each analysis item is determined so that at least analysis items that use the same type of blank sample are continuous. A decision means to
Control means for performing control to execute reagent blank analysis according to the analysis order determined by the determination means;
An analyzer characterized by comprising:
The acquisition means includes
Holding position information storage means for storing holding position information that associates the type of the blank sample with the holding position of the sample container determined for each type of the blank sample;
Detecting means for detecting the presence or absence of the sample container in the holding position;
With
By using the holding position information stored in the holding position information storage unit and the result detected by the detection unit, the type of the blank sample stored in each of the plurality of sample containers held by the holding unit is determined. The analyzer according to claim 1, wherein the analyzer is acquired.
The output means which outputs the information which matched the kind of the said blank sample and the said holding position based on the said holding position information which the said holding position information storage means memorize | stores, The output means is characterized by the above-mentioned. Analysis equipment.
The blank sample information storage means stores the usage amount of the blank sample together with the type of blank sample for each analysis item as the blank sample information,
Comprising calculating means for calculating the amount used for each type of blank sample necessary for reagent blank analysis according to the analysis item received by the receiving means based on the blank sample information stored in the blank sample information storing means,
The analyzer according to claim 4, wherein the output unit outputs a usage amount for each type of the blank sample calculated by the calculation unit.
The acquisition means includes
The blank sample type is obtained by reading the identification information from a recording means provided in the sample container and recording identification information for identifying the type of the blank sample in the sample container. 3. The analyzer according to 1 or 2.