WO2009036876A1 - Selective product applicator - Google Patents

Selective product applicator Download PDF

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Publication number
WO2009036876A1
WO2009036876A1 PCT/EP2008/007119 EP2008007119W WO2009036876A1 WO 2009036876 A1 WO2009036876 A1 WO 2009036876A1 EP 2008007119 W EP2008007119 W EP 2008007119W WO 2009036876 A1 WO2009036876 A1 WO 2009036876A1
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WO
WIPO (PCT)
Prior art keywords
skin
product applicator
product
cosmetic
spray head
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PCT/EP2008/007119
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German (de)
French (fr)
Inventor
Sören JASPERS
Nils Hoffmann
Thomas Blatt
Original Assignee
Beiersdorf Ag
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Publication of WO2009036876A1 publication Critical patent/WO2009036876A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/02Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A61M15/025Bubble jet droplet ejection devices

Definitions

  • the present invention relates to a method for the selective application of cosmetic or pharmaceutical formulations to the skin and to a selective product applicator for cosmetic or pharmaceutical formulations.
  • US 2006/0016999 A1 discloses a device which indicates to the user the type of cosmetic sunscreen preparation needed.
  • the intensity of the UVA and UVB radiation of the sunlight is detected by corresponding sensors.
  • the preparation needed to protect the skin is calculated on the basis of appropriately preselected data on the individual skin properties and displayed to the user via optical or acoustic signals.
  • automatic application of the corresponding preparation does not take place.
  • WO 02/087681 a method for the administration of therapeutic agents is known, in which a device implanted to the patient generates a signal which controls the delivery of an active substance from an active substance plaster adhered to the skin of the patient.
  • a device implanted to the patient generates a signal which controls the delivery of an active substance from an active substance plaster adhered to the skin of the patient.
  • no substances acting on or only in the upper layers of the skin can be used, since they do not or only in very small, ineffective amounts enter the body of a patient.
  • the method of skin care or skin treatment is not suitable because only relatively small areas of skin can be covered with a patch. It is therefore an object of the present invention to provide a method and a suitable device which enable a selective application of cosmetic or pharmaceutical preparations for skin care or skin treatment.
  • the object is achieved in a first aspect by a method in which first the coloration of the skin, the skin relief or both over the entire surface of a selected skin surface is optically detected, the areas are determined within which the data deviate from target values, and then the cosmetic or pharmaceutical preparations are released on these surfaces.
  • Preferred embodiments of the method are the subject of the subclaims.
  • Measurements of the skin roughness on the measurement of shadows of an obliquely illuminated skin area are known. The deeper the grooves in the viewed skin section, the longer shadows they cast. Also known are methods for determining skin color, in which light rays reflected at the skin surface are detected. It uses the phenomenon that a light beam incident on the skin is reflected with changed wavelength distribution depending on the color of the skin. These measurements can be performed with both white light and narrowband (colored) light.
  • the light reflected on the skin surface is detected via corresponding sensors.
  • the change in intensity, the change in the wavelength of the reflected light or both are detected in comparison to the incident light.
  • the values obtained are compared with setpoints or setpoint ranges.
  • the setpoint values can be determined in advance, for example, by appropriate measurements on wrinkle-free skin areas with a lower relief depth or uniformly pigmented skin areas.
  • Another method for determining the setpoint values is, for example, to determine mean values from the measured values during the measurement itself, which values are used as setpoint values or setpoint range. It is important to be able to record the structure of the skin surface either cell-like (line scanner) or flat (CCD camera).
  • Preparations which contain active ingredients are preferably used according to the invention.
  • the choice of active ingredients depends on the type of skin change and the desired effect. Thus, for example, to smooth the skin roughness moisturizing or wrinkle-reducing agents are suitable, while for alleviating unwanted color change lightening, tinting or anti-inflammatory agents are suitable.
  • the method according to the invention is preferably used for targeted reduction of wrinkles, for targeted pigment lightening or coloring and for targeted treatment of acne, inflammations, redness and irritation, and insect bites.
  • the pharmaceutical or cosmetic preparations used in the process according to the invention have active substances, individually or in combination, which are suitable for the particular application.
  • Suitable active ingredients are, for example, the following active ingredients selected from the group of biochinones, in particular ubiquinone (QlO), ubiquinol, folic acid and its derivatives, in particular tetrahydrofolic acid and dihydrofolic acid, niacin and its derivatives, in particular niacinamide, creatine and creatinine, carnitine, biotin, isoflavone, cardiolipin , Lipoic acid, anti-freezing proteins, Pimpinella anis fruit extract, hop and hop malt extracts, agents that promote connective tissue restructuring such as natural and synthetic isoflavonoids and isoflavonoid-containing plant extracts such as soy and clover - Extracts, active ingredients to support the skin functions in dry skin such as vitamin C, biotin, carnitine, propionic acid, green tea extracts, eucalyptus oil, urea and mineral salts such as NaCl, marine minerals and osmolytes eg inos
  • Active substances in encapsulated form can also be used in the process according to the invention, in particular alpha-, beta-, HP-beta, random-Me-beta, gamma-cyclodextrin, cellulose, gelatin, wax or liposomes being used as encapsulation materials serve.
  • a selective product applicator which has at least one optoelectronic sensor, at least one product reservoir, a data processing unit and at least one electrically triggered device for releasing liquids.
  • Preferred embodiments of the product applicator are the subject of the subclaims.
  • the opto-electronic sensors and the liquid-dispensing devices connected to the product reservoirs are connected to the data processing unit.
  • the product applicator according to the invention in the form of a pin, which can be operated or applied with one hand. All components are chosen so that they can be arranged in a housing which can be held in one hand.
  • the electrically triggered device for releasing liquids has a spray head.
  • the spray head can have a micropump, wherein, for example, diaphragm pumps or piston pumps are used. Micro diaphragm pumps often use the piezo effect (piezo diaphragm micropumps) mentioned below.
  • a preferred embodiment of the present invention is the use of overpressure containers and microvalves (corresponding to the technique used in the airbrush method).
  • the spray head comprises a bubble jet spray head or a piezo spray head. In a spray head according to the bubble jet method, which is referred to below as a bubble jet spray head, tiny drops of liquid are generated by means of a heating element.
  • a vapor bubble forms explosively, which presses a drop of liquid out of a nozzle by its pressure.
  • the property of piezocrystals is used to deform under electrical tension to force fluid through a nozzle.
  • the drop formation of the liquid occurs, whereby the drop volume can be controlled via the applied electrical pulse.
  • the operating frequency of a piezocrystal reaches up to 23 kHz.
  • the preparation to be released must not be too hot, so that the active ingredients are not destroyed.
  • the viscosity, the maximum Ambichen Anlagen- 'and the agglomeration behavior of the particles of the composition to be released on the pump power and the nozzle geometry of the device used must be tuned to allow a targeted release.
  • CCD Charge Coupled Device
  • the measured value acquisition according to the present invention is an evaluation of the light intensity distribution.
  • a special optical arrangement e.g. Angle between the optical axes of the light source and the recording unit to better determine the wrinkle expression is to pay attention to the exact location assignment between the intensity signal and the application target area.
  • the light intensity can be recorded as a sum signal or spectrally differentiating via optical or electronic filters.
  • the trigger signal for the application can be obtained via a threshold value of the intensity or from threshold value combinations of different spectral intensities.
  • the threshold value or the threshold value combinations must be determined individually for each skin in a "training mode.”
  • optical iris may be required in order to focus the training particularly selectively on specific skin characteristics.
  • the present object is achieved by the use of the product applicator according to the invention for the selective application of cosmetic or pharmaceutical preparations on the skin.
  • the applicator according to the invention is preferred for the application of pharmaceutical and cosmetic preparations for the treatment of acne, wrinkles and other signs of aging as well as pigmentation disorders.
  • Preparations suitable according to the invention are solutions, for example aqueous and / or alcoholic solutions (concentrates), emulsions, gels, melts, serums and make-up.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a method and a device for the selective application of cosmetic or pharmaceutical preparations on the skin.

Description

Selektiver Produktapplikator Selective product applicator
Die vorliegende Erfindung betrifft ein Verfahren zur selektiven Applikation von kosmetischen oder pharmazeutischen Formulierungen auf die Haut sowie einen selektiven Produktapplikator für kosmetische oder pharmazeutische Formulierungen.The present invention relates to a method for the selective application of cosmetic or pharmaceutical formulations to the skin and to a selective product applicator for cosmetic or pharmaceutical formulations.
Aus US 2006/0016999 Al ist eine Vorrichtung bekannt, welche dem Verwender die Art der benotigten kosmetischen Sonnenschutz-Zubereitung anzeigt. Dabei wird die Intensität der UVA- und UVB-Strahlung des Sonnenlichts über entsprechende Sensoren erfasst. Über eine Datenverarbeitungseinheit wird anhand entsprechend vorgewählter Daten zu den individuellen Hauteigenschaften die zum Schutz der Haut benötigte Zubereitung berechnet und dem Verwender über optische oder akustische Signale angezeigt. Eine automatische Applikation der entsprechenden Zubereitung erfolgt jedoch nicht.US 2006/0016999 A1 discloses a device which indicates to the user the type of cosmetic sunscreen preparation needed. The intensity of the UVA and UVB radiation of the sunlight is detected by corresponding sensors. By means of a data processing unit, the preparation needed to protect the skin is calculated on the basis of appropriately preselected data on the individual skin properties and displayed to the user via optical or acoustic signals. However, automatic application of the corresponding preparation does not take place.
Aus WO 02/087681 ist ein Verfahren zur Verabreichung therapeutischer Wirkstoffe bekannt, in dem eine dem Patienten implantierte Vorrichtung ein Signal erzeugt, welches die Abgabe eines Wirkstoffes aus einem auf die Haut des Patienten geklebten Wirkstoff-Pflasters steuert. Jedoch können in diesem Verfahren keine auf bzw. nur in den oberen Schichten der Haut wirkenden Substanzen eingesetzt werden, da diese nicht oder nur in sehr geringen, unwirksamen Mengen in den Körper eines Patienten gelangen. Auch ist das Verfahren zur Hautpflege oder Hautbehandlung nicht geeignet, da nur verhältnismäßig kleine Hautareale mit einem Pflaster abgedeckt werden können. Aufgabe der vorliegenden Erfindung ist es daher ein Verfahren sowie eine geeignete Vorrichtung zur Verfügung zu stellen, welche eine selektive Applikation von kosmetischen oder pharmazeutischen Zubereitungen zur Hautpflege oder Hautbehandlung ermöglichen.From WO 02/087681 a method for the administration of therapeutic agents is known, in which a device implanted to the patient generates a signal which controls the delivery of an active substance from an active substance plaster adhered to the skin of the patient. However, in this method, no substances acting on or only in the upper layers of the skin can be used, since they do not or only in very small, ineffective amounts enter the body of a patient. Also, the method of skin care or skin treatment is not suitable because only relatively small areas of skin can be covered with a patch. It is therefore an object of the present invention to provide a method and a suitable device which enable a selective application of cosmetic or pharmaceutical preparations for skin care or skin treatment.
Die Aufgabe wird in einem ersten Aspekt durch ein Verfahren gelöst, in welchem zunächst die Färbung der Haut, das Hautrelief oder beides über die gesamte Fläche einer ausgewählten Hautoberfläche optisch erfasst wird, die Flächen bestimmt werden, innerhalb derer die Daten von Sollwerten abweichen, und dann die kosmetischen oder pharmazeutischen Zubereitungen auf diesen Flächen freigesetzt werden. Bevorzugte Ausführungsformen des Verfahrens sind Gegenstand der Unteransprüche.The object is achieved in a first aspect by a method in which first the coloration of the skin, the skin relief or both over the entire surface of a selected skin surface is optically detected, the areas are determined within which the data deviate from target values, and then the cosmetic or pharmaceutical preparations are released on these surfaces. Preferred embodiments of the method are the subject of the subclaims.
Messungen der Hautrauhigkeit über das Ausmessen von Schatten eines schräg angeleuchteten Hautareals sind bekannt. Je tiefer die Rillen in dem .betrachteten Hautabschnitt sind, desto längere Schatten werfen sie. Ebenso sind Verfahren zur Bestimmung der Hautfarbe bekannt, in denen an der Hautoberfläche reflektierte Lichtstrahlen erfasst werden. Dabei wird das Phänomen genutzt, dass ein auf die Haut auftreffender Lichtstrahl in Abhängigkeit von der Farbe der Haut mit veränderter Wellenlängenverteilung reflektiert wird. Diese Messungen können sowohl mit Weißlicht als auch mit engerbandigem (farbigem) Licht durchgeführt werden.Measurements of the skin roughness on the measurement of shadows of an obliquely illuminated skin area are known. The deeper the grooves in the viewed skin section, the longer shadows they cast. Also known are methods for determining skin color, in which light rays reflected at the skin surface are detected. It uses the phenomenon that a light beam incident on the skin is reflected with changed wavelength distribution depending on the color of the skin. These measurements can be performed with both white light and narrowband (colored) light.
In dem erfindungsgemäßen Verfahren wird das an der Hautoberfläche reflektierte Licht über entsprechende Sensoren erfasst. In einer bevorzugten Ausführungsform der Erfindung werden die Änderung der Intensität, die Änderung der Wellenlänge des reflektierten Lichts oder beides im Vergleich zum eingestrahlten Licht erfasst.In the method according to the invention, the light reflected on the skin surface is detected via corresponding sensors. In a preferred embodiment According to the invention, the change in intensity, the change in the wavelength of the reflected light or both are detected in comparison to the incident light.
Die erhaltenen Werte werden mit Sollwerten bzw. Sollwertbereichen verglichen. Die Sollwerte können beispielsweise vorab durch entsprechende Messungen an faltenfreien Hautarealen mit geringerer Relieftiefe oder gleichmäßig pigmentierten Hautarealen ermittelt werden. Ein anderes Verfahren zur Bestimmung der Sollwerte ist beispielsweise während der Messung selbst aus den gemessenen Werten Mittelwerte zu bestimmen, welche als Sollwerte oder Sollwertbereich eingesetzt werden. Wichtig dabei ist die Möglichkeit, die Struktur der Hautoberfläche entweder zellenförmig (Linienscanner) oder flächig (CCD-Kamera) zu erfassen.The values obtained are compared with setpoints or setpoint ranges. The setpoint values can be determined in advance, for example, by appropriate measurements on wrinkle-free skin areas with a lower relief depth or uniformly pigmented skin areas. Another method for determining the setpoint values is, for example, to determine mean values from the measured values during the measurement itself, which values are used as setpoint values or setpoint range. It is important to be able to record the structure of the skin surface either cell-like (line scanner) or flat (CCD camera).
Liegen die gemessenen Daten einer Hautfläche außerhalb der vorgegebenen Bereiche, wird gezielt auf dieser Fläche eine kosmetische oder pharmazeutische Zubereitung freigesetzt .If the measured data of a skin area lie outside the predetermined areas, a cosmetic or pharmaceutical preparation is deliberately released on this area.
Erfindungsgemäß bevorzugt werden Zubereitungen eingesetzt, welche Wirkstoffe enthalten. Die Wahl der Wirkstoffe hängt dabei von der Art der Hautveränderung und der gewünschten Wirkung ab. So sind beispielsweise zur Glättung der Hautrauhigkeit feuchtigkeitsspendende oder faltenmindernde Wirkstoffe geeignet, während zur Milderung von unerwünschten Farbveränderung aufhellende, tönende oder entzündungshemmende Wirkstoffe geeignet sind. Das erfindungsgemäße Verfahren wird bevorzugt zur gezielten Faltenminderung, zur gezielten Pigmentaufhellung oder Färbung und zur gezielten Behandlung bei Akne, Entzündungen, Rötungen und Irritationen sowie Insektenstichen eingesetzt werden.Preparations which contain active ingredients are preferably used according to the invention. The choice of active ingredients depends on the type of skin change and the desired effect. Thus, for example, to smooth the skin roughness moisturizing or wrinkle-reducing agents are suitable, while for alleviating unwanted color change lightening, tinting or anti-inflammatory agents are suitable. The method according to the invention is preferably used for targeted reduction of wrinkles, for targeted pigment lightening or coloring and for targeted treatment of acne, inflammations, redness and irritation, and insect bites.
Es ist besonders vorteilhaft, wenn die im erfindungsgemäßen Verfahren eingesetzten pharmazeutischen oder kosmetischen Zubereitungen Wirkstoffe, einzeln oder in Kombination, aufweisen, die für die jeweilige Anwendung geeignet sind.It is particularly advantageous if the pharmaceutical or cosmetic preparations used in the process according to the invention have active substances, individually or in combination, which are suitable for the particular application.
Geeignete Wirkstoffe sind beispielsweise die folgenden Wirkstoffe, gewählt aus der Gruppe der Biochinone, insbesondere Ubichinon (QlO), Ubichinol, Folsäure und ihre Derivate insbesondere TetrahydrofÖlsäure und DihydrofÖlsäure, Niacin und seine Derivate insbesondere Niacinamid, Kreatin und Kreatinin, Carnitin, Biotin, Isoflavon, Cardiolipin, Liponsäure, Anti-Freezing-Pro- teine, Pimpinella-anis-fruit-extract , Hopfen- und Hopfen- Malz-Extrakte, Wirkstoffe, welche die Restrukturierung des Bindegewebes fördern wie natürliche und synthetische Isoflavonoide und isoflavonoidhaltige Pflanzenextrakte wie z.B. Soja- und Klee-Extrakte, Wirkstoffe zur Unterstützung der Hautfunktionen bei trockener Haut wie beispielsweise Vitamin C, Biotin, Carnitin, Propionsäure, Grüntee-Extrakte, Eucalyptusöl, Harnstoff und Mineralsalze wie z.B. NaCl, Meeresmineralien sowie Osmolyte z.B. Inositol, Betain und quartäre Ammoniumverbindungen, Wirkstoffe zur Linderung bzw. positiven Beeinflussung von irritativen Hautzuständen bei empfindlicher Haut im allgemeinen oder bei durch Noxen wie beispielsweise UV- Strahlung oder Chemikalien gereizter Haut wie Sericoside, verschiedene Extrakte des Süßholzes, Licochalcone insbesondere Licochalcon A, Silymarin, Silyphos, Dexpanthenol, Inhibitoren des Prostaglandinstoffwechsels insbesondere der Cyclooxygenase und des Leukotrien- stoffwechsels insbesondere der 5-Lipoxygenase und des 5- Lipoxygenase-Inhibitor-Proteins, FLAP, Modulatoren der Pigmentierung, welche die Pigmentierung der Haut vermindern, wie beispielsweise Tyrosinsulfat , Dioic acid (8-Hexadecen-l, 16-dicarbonsäure) sowie Liponsäure und Liponamid, verschiedene Extrakte des Süßholzes, Koji- säure, Hydrochinon, Arbutin, Alpha-Arbutin, Deoxyarbutin, Fruchtsäuren insbesondere Alpha-Hydroxy-Säuren (AHAs) , Bärentrauben-Extrakte (Bearberry oder Uvae ursi), Ursolsäure, Ascorbinsäure, Grüntee-Extrakte, Amino- guanidin, Pyridoxamin, Niacinamid, Inhibitoren des Proteinase Activated Receptors 2 (PAR-2), Wirkstoffe, die eine verstärkte oder schnellere Bräunung der Haut mit oder ohne Einfluss von UV-Licht herbeiführen, beispielsweise Advanced Glycation Endproducts (AGE) , Lipofuscine, Nukleinsäure-Oligonukleotide, Purine und Pyrimidine, NO-freisetzende Substanzen, Tyrosin und seine Derivate insbesondere N-Acetyl-Tyrosin, Phenylalanin und seine Derivate insbesondere N-Acetyl-Phenylalanin sowie Aktivatoren des Proteinase Activated Receptors 2 (PAR-2) , Antifaltenwirkstoffe wie Flavonglycoside insbesondere α- Glycosylrutin, Coenzym QlO, Vitamin E und seine Derivate. In dem erfindungsgemäßen Verfahren können auch Wirkstoffe in verkapselter Form eingesetzt werden, wobei als Verkapselungsmaterialien z.B. Kollagenmatrices, cyclische Oligosaccharide insbesondere alpha-, beta-, HP-beta-, random-Me-beta, gamma-Cyclodextrin, Cellulose, Gelatine, Wachs oder Liposomen dienen. In einem weiteren Aspekt wird die vorliegende Aufgabe durch selektiven Produktapplikator gelöst, welcher mindestens einen optoelektronischen Sensor, mindestens ein Produktreservoir, eine Datenverarbeitungseinheit und mindestens eine elektrisch ausgelöste Vorrichtung zur Freisetzung von Flüssigkeiten aufweist. Bevorzugte Ausführungsformen des Produktapplikators sind Gegenstand der Unteransprüche.Suitable active ingredients are, for example, the following active ingredients selected from the group of biochinones, in particular ubiquinone (QlO), ubiquinol, folic acid and its derivatives, in particular tetrahydrofolic acid and dihydrofolic acid, niacin and its derivatives, in particular niacinamide, creatine and creatinine, carnitine, biotin, isoflavone, cardiolipin , Lipoic acid, anti-freezing proteins, Pimpinella anis fruit extract, hop and hop malt extracts, agents that promote connective tissue restructuring such as natural and synthetic isoflavonoids and isoflavonoid-containing plant extracts such as soy and clover - Extracts, active ingredients to support the skin functions in dry skin such as vitamin C, biotin, carnitine, propionic acid, green tea extracts, eucalyptus oil, urea and mineral salts such as NaCl, marine minerals and osmolytes eg inositol, betaine and quaternary ammonium compounds, active ingredients for relief or positive influence of irritati skin conditions in sensitive skin in general or in skin irritated by noxious substances such as UV radiation or chemicals such as sericosides, various extracts of licorice, Licochalcone particular licochalcone A, silymarin, silyphos, dexpanthenol, inhibitors of prostaglandin metabolism in particular the cyclooxygenase and leukotriene metabolism in particular the 5-lipoxygenase and the 5-lipoxygenase inhibitor protein, FLAP, modulators of pigmentation, which Pigmentation of the skin, such as tyrosine sulfate, dioic acid (8-hexadecene-l, 16-dicarboxylic acid) and lipoic acid and lipoamide, various extracts of licorice, kojic acid, hydroquinone, arbutin, alpha-arbutin, deoxyarbutin, fruit acids, especially alpha Hydroxy acids (AHAs), bearberry extracts (Bearberry or Uvae ursi), ursolic acid, ascorbic acid, green tea extracts, amino guanidine, pyridoxamine, niacinamide, inhibitors of Proteinase Activated Receptor 2 (PAR-2), agents that have been enhanced or bring about faster tanning of the skin with or without the influence of UV light, for example Advanced Glycation endproducts (AGE), lipofuscins, nucleic acid oligonucleotides, purines and pyrimidines, NO-releasing substances, tyrosine and its derivatives, in particular N-acetyl-tyrosine, phenylalanine and its derivatives, in particular N-acetyl-phenylalanine and activators of the proteinase activated receptor 2 (PAR-2), anti-wrinkle agents such as flavone glycosides especially α-glycosylrutin, coenzyme Q10, vitamin E and its derivatives. Active substances in encapsulated form can also be used in the process according to the invention, in particular alpha-, beta-, HP-beta, random-Me-beta, gamma-cyclodextrin, cellulose, gelatin, wax or liposomes being used as encapsulation materials serve. In a further aspect, the present object is achieved by a selective product applicator which has at least one optoelectronic sensor, at least one product reservoir, a data processing unit and at least one electrically triggered device for releasing liquids. Preferred embodiments of the product applicator are the subject of the subclaims.
In einer bevorzugten Ausführungsform der vorliegenden Erfindung sind die optoelektronischen Sensoren und die mit den Produktreservoiren verbundenen Vorrichtungen zur Freisetzung von Flüssigkeiten mit der Datenverarbeitungseinheit verbunden.In a preferred embodiment of the present invention, the opto-electronic sensors and the liquid-dispensing devices connected to the product reservoirs are connected to the data processing unit.
In einer weiteren bevorzugten Ausführungsform der Erfindung weist der erfindungsgemäße Produktapplikator die Form eines Stifts auf, der mit einer Hand betätigt bzw. angewendet werden kann. Alle Bauelemente sind dabei so gewählt, dass sie in einem Gehäuse angeordnet werden können, welches in einer Hand gehalten werden kann.In a further preferred embodiment of the invention, the product applicator according to the invention in the form of a pin, which can be operated or applied with one hand. All components are chosen so that they can be arranged in a housing which can be held in one hand.
Es ist erfindungsgemäß bevorzugt, dass die elektrisch ausgelöste Vorrichtung zur Freisetzung von Flüssigkeiten einen Sprühkopf aufweist. Der Sprühkopf kann dabei eine Mikropumpe aufweisen, wobei beispielsweise Membranpumpen oder Kolbenpumpen eingesetzt werden. Mikromembranpumpen nutzen häufig den unten angeführten Piezoeffekt (Piezomembran-Mikropumpen) . Eine bevorzugte Ausführungsform der vorliegenden Erfindung ist die Verwendung von Überdruckbehältern und Mikroventilen (entsprechend der beim Airbrush-Verfahren eingesetzten Technik) . Es ist weiterhin erfindungsgemäß bevorzugt, dass der Sprühkopf einen Bubble-Jet-Sprühkopf oder einen Piezo- Sprühkopf aufweist. In einem Sprühkopf nach dem Bubble- Jet-Verfahren, der im Folgenden als Bubble-Jet-Sprühkopf bezeichnet wird, werden winzige Flüssigkeitstropfen mit Hilfe eines Heizelements erzeugt. Dabei bildet sich explosionsartig eine Dampfblase, die durch ihren Druck einen Flüssigkeitstropfen aus einer Düse presst. In einem Piezo-Sprühkopf wird die Eigenschaft von Piezokristallen genutzt, sich unter elektrischer Spannung zu verformen, um Flüssigkeit durch eine Düse zu pressen. Es erfolgt die Tropfenbildung der Flüssigkeit, wobei sich das Tropfenvolumen über den angelegten elektrischen Impuls steuern lässt. Die Arbeitsfrequenz eines Piezokristalls reicht bis zu 23 kHz.It is inventively preferred that the electrically triggered device for releasing liquids has a spray head. The spray head can have a micropump, wherein, for example, diaphragm pumps or piston pumps are used. Micro diaphragm pumps often use the piezo effect (piezo diaphragm micropumps) mentioned below. A preferred embodiment of the present invention is the use of overpressure containers and microvalves (corresponding to the technique used in the airbrush method). It is further preferred according to the invention that the spray head comprises a bubble jet spray head or a piezo spray head. In a spray head according to the bubble jet method, which is referred to below as a bubble jet spray head, tiny drops of liquid are generated by means of a heating element. As a result, a vapor bubble forms explosively, which presses a drop of liquid out of a nozzle by its pressure. In a piezo spray head, the property of piezocrystals is used to deform under electrical tension to force fluid through a nozzle. The drop formation of the liquid occurs, whereby the drop volume can be controlled via the applied electrical pulse. The operating frequency of a piezocrystal reaches up to 23 kHz.
Wichtig ist dabei, dass die freizusetzende Zubereitung nicht zu heiß werden darf, damit die Wirkstoffe nicht zerstört werden. Darüber hinaus müssen auch die Viskosität, die maximale Partikelgröße-' und das Agglomerationsverhalten der Partikel der freizusetzenden Zubereitung auf die Pumpleistung und die Düsengeometrie der eingesetzten Vorrichtung abgestimmt sein, um eine gezielte Freisetzung zu ermöglichen.It is important that the preparation to be released must not be too hot, so that the active ingredients are not destroyed. In addition, the viscosity, the maximum Teilchengröße- 'and the agglomeration behavior of the particles of the composition to be released on the pump power and the nozzle geometry of the device used must be tuned to allow a targeted release.
In einer weiteren bevorzugten Ausführungsform der vorliegenden Erfindung werden als optoelektronische Sensoren Photodioden, Phototransistoren oder CCD-Elemente bzw. CCD-Sensoren (CCD: Charge coupled device) einzeln oder in Kombination eingesetzt. Erfindungsgemäß bevorzugt ist der Einsatz von CCD-Sensoren wie sie beispielsweise in Scannern verwendet werden. CCD-Sensoren erlauben durch ihre hohe Empfindlichkeit die Erfassung von sehr schwachen Lichtstrahlen. Sie besitzen darüber hinaus eine breite spektrale Empfindlichkeit und einen hohen Dynamikumfang, d.h. sie können gleichzeitig sehr lichtschwache und sehr helle Bereiche eines Bildes erfassen.In a further preferred embodiment of the present invention, photodiodes, phototransistors or CCD elements or CCD sensors (CCD: Charge Coupled Device) are used individually or in combination as optoelectronic sensors. According to the invention, the use of CCD sensors, as used for example in scanners, is preferred. Due to their high sensitivity, CCD sensors allow very high detection weak light rays. They also have a wide spectral sensitivity and a high dynamic range, ie they can simultaneously capture very faint and very bright areas of an image.
Die Messwerterfassung gemäß der vorliegenden Erfindung ist eine Auswertung der Lichtintensitätsverteilung. Bei spezieller optischer Anordnung z.B. Winkel zwischen den optischen Achsen der Lichtquelle und der Aufnahmeeinheit zur besseren Bestimmung der Faltenausprägung ist auf die exakte Ortszuordnung zwischen Intensitätssignal und Applikationszielgebiet zu achten. Die Lichtintensität kann als Summensignal oder spektral differenzierend über optische oder elektronische Filter aufgenommen werden. Das Triggersignal zur Applikation kann über einen Schwellwert der Intensität oder aus Schwellwertkombinationen verschiedener spektraler Intensitäten gewonnen werden. Der Schwellwert bzw. die Schwellwertkombinationen müssen hautindividuell in einem „Trainingsmode" bestimmt werden. Eventuell sind hier optische Blenden erforderlich, um das Training besonders selektiv auf spezifische Hautmerkmale zu fokussieren.The measured value acquisition according to the present invention is an evaluation of the light intensity distribution. For a special optical arrangement, e.g. Angle between the optical axes of the light source and the recording unit to better determine the wrinkle expression is to pay attention to the exact location assignment between the intensity signal and the application target area. The light intensity can be recorded as a sum signal or spectrally differentiating via optical or electronic filters. The trigger signal for the application can be obtained via a threshold value of the intensity or from threshold value combinations of different spectral intensities. The threshold value or the threshold value combinations must be determined individually for each skin in a "training mode." Optionally, optical iris may be required in order to focus the training particularly selectively on specific skin characteristics.
In einem weiteren Aspekt wird die vorliegende Aufgabe gelöst durch die Verwendung des erfindungsgemäßen Produktapplikators zur selektiven Applikation von kosmetischen oder pharmazeutischen Zubereitungen auf der Haut.In a further aspect, the present object is achieved by the use of the product applicator according to the invention for the selective application of cosmetic or pharmaceutical preparations on the skin.
Bevorzugt wird der erfindungsgemäße Applikator zur Applikation von pharmazeutischen und kosmetischen Zubereitungen zur Behandlung von Akne, Falten und anderen Alterserscheinungen sowie Pigmentstörungen. Erfindungsgemäß geeignete Zubereitungen sind Lösungen, beispielsweise wässrige und/oder alkoholische Lösungen (Konzentrate) , Emulsionen, Gele, Schmelzen, Seren und Make-up. The applicator according to the invention is preferred for the application of pharmaceutical and cosmetic preparations for the treatment of acne, wrinkles and other signs of aging as well as pigmentation disorders. Preparations suitable according to the invention are solutions, for example aqueous and / or alcoholic solutions (concentrates), emulsions, gels, melts, serums and make-up.

Claims

Patentansprüche claims
1. Verfahren zur selektiven Applikation von kosmetischen oder pharmazeutischen Zubereitungen auf der Haut, dadurch gekennzeichnet, dass zunächst die Färbung und/oder das Relief über die gesamte Fläche einer ausgewählten Hautoberfläche optisch erfasst wird, die Flächen bestimmt werden, innerhalb derer die Daten von Sollwerten abweichen, und dann die kosmetischen oder pharmazeutischen Zubereitungen auf diesen Flächen freigesetzt werden.1. A method for the selective application of cosmetic or pharmaceutical preparations on the skin, characterized in that first the color and / or the relief over the entire surface of a selected skin surface is optically detected, the areas are determined within which the data deviate from target values and then the cosmetic or pharmaceutical preparations are released on these surfaces.
2. Verfahren nach Anspruch 1 zur selektiven Applikation kosmetischer oder pharmazeutischer Zubereitungen auf Hautverfärbungen, Hautvertiefungen oder Hauterhöhungen.2. The method of claim 1 for the selective application of cosmetic or pharmaceutical preparations on skin discoloration, skin pits or skin elevations.
3. Verfahren nach Anspruch 2 zur selektiven Applikation kosmetischer oder pharmazeutischer Zubereitungen auf Hautfalten, Hautporen und/oder Hautbereiche mit Pigmentstörungen, insbesondere Pigmentflecke.3. The method according to claim 2 for the selective application of cosmetic or pharmaceutical preparations on skin folds, skin pores and / or skin areas with pigmentation disorders, in particular pigmentation spots.
4. Produktapplikator zur selektiven Applikation, dadurch gekennzeichnet, dass er mindestens einen optoelektronischen Sensor, mindestens ein Produktreservoir, eine Datenverarbeitungseinheit und mindestens eine elektrisch ausgelöste Vorrichtung zur Freisetzung von Flüssigkeiten aufweist.4. Product applicator for selective application, characterized in that it comprises at least one optoelectronic sensor, at least one product reservoir, a data processing unit and at least one electrically triggered device for releasing liquids.
5. Produktapplikator nach Anspruch 4, dadurch gekennzeichnet, dass der oder die Sensoren und die mit einem oder mehreren Produktreservoiren verbundene Vorrichtung oder die mit einem oder mehreren Produktreservoiren verbundenen Vorrichtungen zur Freisetzung der Flüssigkeiten mit der Datenverarbeitungseinheit verbunden sind.5. Product applicator according to claim 4, characterized in that the one or more sensors and connected to one or more product reservoirs Device or connected to one or more product reservoirs devices for releasing the liquids are connected to the data processing unit.
6. Produktapplikator nach einem der Ansprüche 4 bis 5, dadurch gekennzeichnet, dass alle Bauelemente in einem Gehäuse angeordnet sind, wobei das Gehäuse so dimensioniert ist, das es in einer Hand gehalten werden kann, und der Produktapplikator mit einer Hand angewendet werden kann.6. Product applicator according to one of claims 4 to 5, characterized in that all the components are arranged in a housing, wherein the housing is dimensioned so that it can be held in one hand, and the product applicator can be applied with one hand.
7. Produktapplikator nach einem der Ansprüche 4 bis 6, dadurch gekennzeichnet, dass die elektrisch ausgelöste Vorrichtung zur Freisetzung der Flüssigkeiten einen Sprühkopf aufweist.7. Product applicator according to one of claims 4 to 6, characterized in that the electrically triggered device for releasing the liquids has a spray head.
8. Produktapplikator nach Anspruch 7, dadurch gekennzeichnet, dass der Sprühkopf eine Mikropumpe aufweist.8. Product applicator according to claim 7, characterized in that the spray head has a micropump.
9. Produktapplikator nach Anspruch 7 oder 8, dadurch gekennzeichnet, dass der Sprühkopf einen Bubble-Jet- Sprühkopf oder einen Piezo-Sprühkopf aufweist.9. Product applicator according to claim 7 or 8, characterized in that the spray head comprises a bubble jet spray head or a piezo spray head.
10. Produktapplikator nach einem der Ansprüche 4 bis 9, dadurch gekennzeichnet, dass der oder die Sensoren Photodioden, Phototransistoren oder CCD-Elemente aufweisen .10. Product applicator according to one of claims 4 to 9, characterized in that the one or more sensors have photodiodes, phototransistors or CCD elements.
11. Verwendung des Produktapplikators nach einem der Ansprüche 4 bis 10 zur selektiven Applikation von kosmetischen oder pharmazeutischen Zubereitungen auf die Haut.11. Use of the product applicator according to one of claims 4 to 10 for the selective application of cosmetic or pharmaceutical preparations on the skin.
12. Verwendung nach Anspruch 11, dadurch gekennzeichnet, dass die Zubereitungen Lösungen, bevorzugt wässrige und/oder alkoholische Lösungen, Emulsionen, Gele oder Schmelzen sind. 12. Use according to claim 11, characterized in that the preparations are solutions, preferably aqueous and / or alcoholic solutions, emulsions, gels or melts.
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