WO2008129157A3 - Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs - Google Patents

Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs Download PDF

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Publication number
WO2008129157A3
WO2008129157A3 PCT/FR2008/000216 FR2008000216W WO2008129157A3 WO 2008129157 A3 WO2008129157 A3 WO 2008129157A3 FR 2008000216 W FR2008000216 W FR 2008000216W WO 2008129157 A3 WO2008129157 A3 WO 2008129157A3
Authority
WO
WIPO (PCT)
Prior art keywords
carboxamide
pyrazole
amorphous
composition containing
solid composition
Prior art date
Application number
PCT/FR2008/000216
Other languages
English (en)
Other versions
WO2008129157A4 (fr
WO2008129157A2 (fr
Inventor
Jean Alie
Michel Bauer
Jerome Menegotto
Original Assignee
Sanofi Aventis
Jean Alie
Michel Bauer
Jerome Menegotto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020097017532A priority Critical patent/KR20090113305A/ko
Priority to EA200970792A priority patent/EA200970792A1/ru
Priority to BRPI0807575-1A priority patent/BRPI0807575A2/pt
Priority to CA002678801A priority patent/CA2678801A1/fr
Application filed by Sanofi Aventis, Jean Alie, Michel Bauer, Jerome Menegotto filed Critical Sanofi Aventis
Priority to EP08775573A priority patent/EP2132182A2/fr
Priority to CN200880009562A priority patent/CN101641333A/zh
Priority to MX2009008991A priority patent/MX2009008991A/es
Priority to AU2008240507A priority patent/AU2008240507A1/en
Priority to JP2009550302A priority patent/JP2010519246A/ja
Publication of WO2008129157A2 publication Critical patent/WO2008129157A2/fr
Publication of WO2008129157A3 publication Critical patent/WO2008129157A3/fr
Publication of WO2008129157A4 publication Critical patent/WO2008129157A4/fr
Priority to IL200370A priority patent/IL200370A0/en
Priority to US12/543,942 priority patent/US20100076023A1/en
Priority to MA32210A priority patent/MA31244B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention se rapporte à un dérivé de pyrazole-3-carboxamide sous forme amorphe, à une solution solide amorphe le contenant, et plus généralement aux compositions pharmaceutiques le contenant.
PCT/FR2008/000216 2007-02-23 2008-02-20 Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs WO2008129157A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN200880009562A CN101641333A (zh) 2007-02-23 2008-02-20 包含无定形形式的吡唑-3-羧酰胺和稳定赋形剂的无定形固体组合物
BRPI0807575-1A BRPI0807575A2 (pt) 2007-02-23 2008-02-20 Composição sólida amorfa contendo uma pirazol-3-carboxamida em forma amorfa e veículos estabilizantes
CA002678801A CA2678801A1 (fr) 2007-02-23 2008-02-20 Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs
AU2008240507A AU2008240507A1 (en) 2007-02-23 2008-02-20 Amorphous solid composition containing a pyrazole-3-carboxamide in amorphous form and stabilising carriers
EP08775573A EP2132182A2 (fr) 2007-02-23 2008-02-20 Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs
EA200970792A EA200970792A1 (ru) 2007-02-23 2008-02-20 Аморфный твёрдый раствор, содержащий производное пиразол-3-карбоксамида в аморфной форме и стабилизирующие эксципиенты
MX2009008991A MX2009008991A (es) 2007-02-23 2008-02-20 Solucion solida amorfa que contiene un derivado de pirazol-3-carboxamida en forma amorfa y excipientes estabilizadores.
KR1020097017532A KR20090113305A (ko) 2007-02-23 2008-02-20 무정형 형태의 피라졸-3-카르복스아미드 및 안정화 부형제를 함유하는 무정형 고체 조성물
JP2009550302A JP2010519246A (ja) 2007-02-23 2008-02-20 非晶質形態であるピラゾール−３−カルボキサミドおよび安定化担体を含有する非晶質固体組成物
IL200370A IL200370A0 (en) 2007-02-23 2009-08-12 Amorphous solid composition containing a pyrazole-3-carboxamide in amorphous form and stabilising carriers
US12/543,942 US20100076023A1 (en) 2007-02-23 2009-08-19 Amorphous solid composition containing a pyrazole-3-carboxamide in amorphous form and stabilising carriers
MA32210A MA31244B1 (fr) 2007-02-23 2009-09-10 Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0701377A FR2913018A1 (fr) 2007-02-23 2007-02-23 Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs
FR07/01377 2007-02-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/543,942 Continuation US20100076023A1 (en) 2007-02-23 2009-08-19 Amorphous solid composition containing a pyrazole-3-carboxamide in amorphous form and stabilising carriers

Publications (3)

Publication Number Publication Date
WO2008129157A2 WO2008129157A2 (fr) 2008-10-30
WO2008129157A3 true WO2008129157A3 (fr) 2008-12-31
WO2008129157A4 WO2008129157A4 (fr) 2009-03-05

Family

ID=38561793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/000216 WO2008129157A2 (fr) 2007-02-23 2008-02-20 Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs

Country Status (20)

Country Link
US (1) US20100076023A1 (fr)
EP (1) EP2132182A2 (fr)
JP (1) JP2010519246A (fr)
KR (1) KR20090113305A (fr)
CN (1) CN101641333A (fr)
AR (1) AR065410A1 (fr)
AU (1) AU2008240507A1 (fr)
BR (1) BRPI0807575A2 (fr)
CA (1) CA2678801A1 (fr)
CL (1) CL2008000550A1 (fr)
CO (1) CO6210812A2 (fr)
EA (1) EA200970792A1 (fr)
FR (1) FR2913018A1 (fr)
IL (1) IL200370A0 (fr)
MA (1) MA31244B1 (fr)
MX (1) MX2009008991A (fr)
PE (1) PE20081778A1 (fr)
TW (1) TW200846339A (fr)
UY (1) UY30937A1 (fr)
WO (1) WO2008129157A2 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656354A1 (fr) * 1993-12-02 1995-06-07 Sanofi N-pipéridino-3-pyrazolecarboxamide substitué
WO2000046209A1 (fr) * 1999-02-01 2000-08-10 Sanofi-Synthelabo Derives d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant
WO2006021652A1 (fr) * 2004-07-22 2006-03-02 Sanofi-Aventis Procede de preparation de derives n-piperidino-1,5-diphenylpyrazole-3-carboxamide
EP1816125A1 (fr) * 2006-02-02 2007-08-08 Ranbaxy Laboratories, Ltd. Formes cristallines d'un antagoniste du récepteur cannabinoïde CB1 et son procédé de préparation
WO2007103711A2 (fr) * 2006-03-01 2007-09-13 Dr. Reddy's Laboratories Ltd. Formes polymorphes du rimonabant

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761266B1 (fr) * 1997-03-28 1999-07-02 Sanofi Sa Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
EP1844017A1 (fr) * 2005-01-06 2007-10-17 Cadila Healthcare Ltd. Forme amorphe et trois formes cristallines de chlorhydrate de rimonabant
AR053662A1 (es) * 2005-01-21 2007-05-16 Astex Therapeutics Ltd Compuestos de pirazol inhibidores de la actividad quinasa cdk y gsk
KR100678824B1 (ko) * 2005-02-04 2007-02-05 한미약품 주식회사 용해성이 증가된 무정형 타크로리무스 고체분산체 및 이를포함하는 약제학적 조성물
DE102005026755A1 (de) * 2005-06-09 2006-12-14 Basf Ag Herstellung von festen Lösungen schwerlöslicher Wirkstoffe durch Kurzzeitüberhitzung und schnelle Trocknung
US8431609B2 (en) * 2007-02-19 2013-04-30 Darmesh Mahendrabhai Shah Process for preparation of pyrazole derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656354A1 (fr) * 1993-12-02 1995-06-07 Sanofi N-pipéridino-3-pyrazolecarboxamide substitué
WO2000046209A1 (fr) * 1999-02-01 2000-08-10 Sanofi-Synthelabo Derives d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant
WO2006021652A1 (fr) * 2004-07-22 2006-03-02 Sanofi-Aventis Procede de preparation de derives n-piperidino-1,5-diphenylpyrazole-3-carboxamide
EP1816125A1 (fr) * 2006-02-02 2007-08-08 Ranbaxy Laboratories, Ltd. Formes cristallines d'un antagoniste du récepteur cannabinoïde CB1 et son procédé de préparation
WO2007103711A2 (fr) * 2006-03-01 2007-09-13 Dr. Reddy's Laboratories Ltd. Formes polymorphes du rimonabant

Also Published As

Publication number Publication date
FR2913018A1 (fr) 2008-08-29
TW200846339A (en) 2008-12-01
WO2008129157A4 (fr) 2009-03-05
CL2008000550A1 (es) 2008-07-04
US20100076023A1 (en) 2010-03-25
AR065410A1 (es) 2009-06-03
AU2008240507A1 (en) 2008-10-30
IL200370A0 (en) 2010-04-29
MA31244B1 (fr) 2010-03-01
JP2010519246A (ja) 2010-06-03
EP2132182A2 (fr) 2009-12-16
UY30937A1 (es) 2008-09-30
KR20090113305A (ko) 2009-10-29
CA2678801A1 (fr) 2008-10-30
EA200970792A1 (ru) 2010-04-30
PE20081778A1 (es) 2009-01-01
WO2008129157A2 (fr) 2008-10-30
CN101641333A (zh) 2010-02-03
CO6210812A2 (es) 2010-10-20
BRPI0807575A2 (pt) 2014-07-01
MX2009008991A (es) 2009-09-03

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