WO2008081473A3 - Process for preparing clopidogrel - Google Patents

Process for preparing clopidogrel Download PDF

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Publication number
WO2008081473A3
WO2008081473A3 PCT/IN2007/000612 IN2007000612W WO2008081473A3 WO 2008081473 A3 WO2008081473 A3 WO 2008081473A3 IN 2007000612 W IN2007000612 W IN 2007000612W WO 2008081473 A3 WO2008081473 A3 WO 2008081473A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid
thieno
pyridin
acetamide
chlorophenyl
Prior art date
Application number
PCT/IN2007/000612
Other languages
French (fr)
Other versions
WO2008081473A2 (en
Inventor
Niraj Shyamlal Shah
Shriprakash Dhar Dwivedi
Original Assignee
Cadila Healthcare Ltd
Niraj Shyamlal Shah
Shriprakash Dhar Dwivedi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd, Niraj Shyamlal Shah, Shriprakash Dhar Dwivedi filed Critical Cadila Healthcare Ltd
Publication of WO2008081473A2 publication Critical patent/WO2008081473A2/en
Publication of WO2008081473A3 publication Critical patent/WO2008081473A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

A process for the preparation of clopidogrel of formula (I) or its pharmaceutically acceptable salts, solvates, hydrates thereof is disclosed. The process comprises treating (+)-(S)-2-Chlorophenyl-(6,7-dihydro-4H-thieno[3,2- c]pyridin-5-yl)acetamide of formula (II) with acid to provide novel acid salt of (+)-(S)- 2-Chlorophenyl-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetamide of formula (III) wherein in S represent acid selected from hydrochloric acid, hydrobromic acid, phosphoric acid, benzoic acid, succinic acid, oxalic acid, malic acid, maleic acid, methanesulfonic acid, ethane sulfonic acid, benzenesulfonic acid, p-toluene sulfonic acid, nephthalene sulfonic acid and converting acid salt of (+)-(S)-2-Chlorophenyl- (6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetamide to Clopidogrel (I) and its pharmaceutically acceptable salts, hydrates, solvates thereof.
PCT/IN2007/000612 2006-12-29 2007-12-27 Process for preparing clopidogrel WO2008081473A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2165/MUM/2006 2006-12-29
IN2165MU2006 2006-12-29

Publications (2)

Publication Number Publication Date
WO2008081473A2 WO2008081473A2 (en) 2008-07-10
WO2008081473A3 true WO2008081473A3 (en) 2008-11-20

Family

ID=39472559

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000612 WO2008081473A2 (en) 2006-12-29 2007-12-27 Process for preparing clopidogrel

Country Status (1)

Country Link
WO (1) WO2008081473A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020177712A1 (en) * 2001-01-24 2002-11-28 Cadila Healthcare Limited Process to prepare clopidogrel
WO2005026174A1 (en) * 2003-09-11 2005-03-24 Generics [Uk] Limited Novel crystalline polymorphs of clopidogrel
US20050256152A1 (en) * 2003-02-13 2005-11-17 Karlheinz Doser Salt of a sulfonic acid containing clopidogrel and use thereof for the production of pharmaceutical formulations
WO2007144895A1 (en) * 2006-06-12 2007-12-21 Cadila Healthcare Limited Process for the preparation of (s) - (+)-clopidogrel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020177712A1 (en) * 2001-01-24 2002-11-28 Cadila Healthcare Limited Process to prepare clopidogrel
US20050256152A1 (en) * 2003-02-13 2005-11-17 Karlheinz Doser Salt of a sulfonic acid containing clopidogrel and use thereof for the production of pharmaceutical formulations
WO2005026174A1 (en) * 2003-09-11 2005-03-24 Generics [Uk] Limited Novel crystalline polymorphs of clopidogrel
WO2007144895A1 (en) * 2006-06-12 2007-12-21 Cadila Healthcare Limited Process for the preparation of (s) - (+)-clopidogrel

Also Published As

Publication number Publication date
WO2008081473A2 (en) 2008-07-10

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