WO2011092720A3 - Pharmaceutical composition of prasugrel and its pharmaceutically acceptable salts and process for their preparation - Google Patents

Pharmaceutical composition of prasugrel and its pharmaceutically acceptable salts and process for their preparation Download PDF

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Publication number
WO2011092720A3
WO2011092720A3 PCT/IN2011/000066 IN2011000066W WO2011092720A3 WO 2011092720 A3 WO2011092720 A3 WO 2011092720A3 IN 2011000066 W IN2011000066 W IN 2011000066W WO 2011092720 A3 WO2011092720 A3 WO 2011092720A3
Authority
WO
WIPO (PCT)
Prior art keywords
prasugrel
pharmaceutical composition
pharmaceutically acceptable
acceptable salts
preparation
Prior art date
Application number
PCT/IN2011/000066
Other languages
French (fr)
Other versions
WO2011092720A2 (en
Inventor
Manne Satyanarayana Reddy
Srinivasan Thirumalai Rajan
Madhu Elevathingal Nicholas
Karamala Rama Subba Reddy
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2011092720A2 publication Critical patent/WO2011092720A2/en
Publication of WO2011092720A3 publication Critical patent/WO2011092720A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A pharmaceutical composition of prasugrel or its pharmaceutically acceptable salts, especially hydrochloride salts as well as process for their preparation are provided. The pharmaceutical composition comprises: a) prasugrel hydrochloride, b) a water insoluble dry binder, c) at least one diluent, d )at least one disintegrant and e) at least one lubricant. The pharmaceutical composition is optionally coated with a film. An improved process for preparing of prasugrel and its pharmaceutically acceptable salts, a process for purifying 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2 -one hydrochloride compound, a process for preparing crystalline form-B2 of prasugrel hydrochloride and a process for preparing a-cyclopropylcarbonyl-2-fluorobenzyl bromide compound are provided.
PCT/IN2011/000066 2010-02-01 2011-01-31 Pharmaceutical composition of prasugrel and its pharmaceutically acceptable salts WO2011092720A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN244CH2010 2010-02-01
IN244/CHE/2010 2010-02-01

Publications (2)

Publication Number Publication Date
WO2011092720A2 WO2011092720A2 (en) 2011-08-04
WO2011092720A3 true WO2011092720A3 (en) 2011-09-22

Family

ID=44319930

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000066 WO2011092720A2 (en) 2010-02-01 2011-01-31 Pharmaceutical composition of prasugrel and its pharmaceutically acceptable salts

Country Status (1)

Country Link
WO (1) WO2011092720A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103565773B (en) * 2012-08-07 2017-12-05 广东东阳光药业有限公司 A kind of pharmaceutical composition of prasugrel hydrochloride
WO2016122421A1 (en) 2015-01-29 2016-08-04 Pharmactive Ilaç Sanayi Ve Ticaret A.Ş. Stable pharmaceutical compositions containing prasugrel base
GR1009230B (en) 2016-10-12 2018-02-22 Φαρματεν Αβεε Pharmaceutical prasugrel besylate-containing formula

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1298132A1 (en) * 2000-07-06 2003-04-02 Sankyo Company, Limited Hydropyridine derivative acid addition salts
WO2006135605A2 (en) * 2005-06-10 2006-12-21 Eli Lilly And Company Formulation of a thienopyridine platelet aggregation inhibitor
WO2009062044A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel, and its salts and polymorphs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1298132A1 (en) * 2000-07-06 2003-04-02 Sankyo Company, Limited Hydropyridine derivative acid addition salts
WO2006135605A2 (en) * 2005-06-10 2006-12-21 Eli Lilly And Company Formulation of a thienopyridine platelet aggregation inhibitor
WO2009062044A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel, and its salts and polymorphs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JING, YAPING ET AL.: "Synthesis of the intermediate of prasugrel", JOURNAL OF GUANGDONG PHARMACEUTICAL COLLEGE, vol. 25, no. 3, June 2009 (2009-06-01), pages 272 - 274 *

Also Published As

Publication number Publication date
WO2011092720A2 (en) 2011-08-04

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