WO2007145322A1 - 包装材及び薬剤包装用袋 - Google Patents
包装材及び薬剤包装用袋 Download PDFInfo
- Publication number
- WO2007145322A1 WO2007145322A1 PCT/JP2007/062123 JP2007062123W WO2007145322A1 WO 2007145322 A1 WO2007145322 A1 WO 2007145322A1 JP 2007062123 W JP2007062123 W JP 2007062123W WO 2007145322 A1 WO2007145322 A1 WO 2007145322A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- layer
- moisture
- packaging material
- packaging
- bag
- Prior art date
Links
- 239000005022 packaging material Substances 0.000 title claims abstract description 78
- 238000004806 packaging method and process Methods 0.000 title claims abstract description 36
- 229940126601 medicinal product Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 229920005989 resin Polymers 0.000 claims abstract description 13
- 239000011347 resin Substances 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims description 63
- 238000009512 pharmaceutical packaging Methods 0.000 claims description 34
- 238000007789 sealing Methods 0.000 claims description 27
- 238000010521 absorption reaction Methods 0.000 claims description 25
- 229920001684 low density polyethylene Polymers 0.000 claims description 23
- 239000004702 low-density polyethylene Substances 0.000 claims description 23
- 239000003230 hygroscopic agent Substances 0.000 claims description 21
- 229920002239 polyacrylonitrile Polymers 0.000 claims description 17
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims description 8
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims description 8
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 4
- 238000003860 storage Methods 0.000 abstract description 7
- 230000002745 absorbent Effects 0.000 abstract description 5
- 239000002250 absorbent Substances 0.000 abstract description 5
- 230000007774 longterm Effects 0.000 abstract description 5
- 239000010410 layer Substances 0.000 description 132
- 229940079593 drug Drugs 0.000 description 28
- 230000035699 permeability Effects 0.000 description 23
- 238000000034 method Methods 0.000 description 19
- 229920001903 high density polyethylene Polymers 0.000 description 15
- 239000004700 high-density polyethylene Substances 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 12
- 238000001179 sorption measurement Methods 0.000 description 12
- 229920000139 polyethylene terephthalate Polymers 0.000 description 10
- 239000005020 polyethylene terephthalate Substances 0.000 description 10
- 239000011888 foil Substances 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 229910052782 aluminium Inorganic materials 0.000 description 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- -1 polypropylene, ethylene butyl acetate Polymers 0.000 description 7
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 6
- 235000019341 magnesium sulphate Nutrition 0.000 description 6
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 6
- 239000012488 sample solution Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 229920000298 Cellophane Polymers 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000012086 standard solution Substances 0.000 description 4
- 239000006200 vaporizer Substances 0.000 description 4
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 3
- 101100468589 Arabidopsis thaliana RH30 gene Proteins 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 238000003475 lamination Methods 0.000 description 3
- 229960001047 methyl salicylate Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000002274 desiccant Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical compound CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 101100468575 Arabidopsis thaliana RH25 gene Proteins 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 229910018001 MKC210 Inorganic materials 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000005219 brazing Methods 0.000 description 1
- YZDQQFAZKLGTQK-UHFFFAOYSA-N butanoic acid;ethene Chemical compound C=C.CCCC(O)=O YZDQQFAZKLGTQK-UHFFFAOYSA-N 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N butyl alcohol Substances CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009820 dry lamination Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229920005992 thermoplastic resin Polymers 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009816 wet lamination Methods 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
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- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
- B32B27/304—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl halide (co)polymers, e.g. PVC, PVDC, PVF, PVDF
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
- B32B27/306—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl acetate or vinyl alcohol (co)polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
- B32B27/308—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising acrylic (co)polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/34—Layered products comprising a layer of synthetic resin comprising polyamides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B3/00—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form
- B32B3/02—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form characterised by features of form at particular places, e.g. in edge regions
- B32B3/06—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form characterised by features of form at particular places, e.g. in edge regions for securing layers together; for attaching the product to another member, e.g. to a support, or to another product, e.g. groove/tongue, interlocking
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2264/00—Composition or properties of particles which form a particulate layer or are present as additives
- B32B2264/10—Inorganic particles
- B32B2264/102—Oxide or hydroxide
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2264/00—Composition or properties of particles which form a particulate layer or are present as additives
- B32B2264/10—Inorganic particles
- B32B2264/104—Oxysalt, e.g. carbonate, sulfate, phosphate or nitrate particles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2264/00—Composition or properties of particles which form a particulate layer or are present as additives
- B32B2264/10—Inorganic particles
- B32B2264/105—Metal
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- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2264/00—Composition or properties of particles which form a particulate layer or are present as additives
- B32B2264/10—Inorganic particles
- B32B2264/107—Ceramic
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- B32B2307/00—Properties of the layers or laminate
- B32B2307/30—Properties of the layers or laminate having particular thermal properties
- B32B2307/31—Heat sealable
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/71—Resistive to light or to UV
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/726—Permeability to liquids, absorption
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
- B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
- B65D81/267—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants the absorber being in sheet form
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
Definitions
- the hygroscopic layer is formed of a first composition containing a hygroscopic agent and a resin component,
- the moisture permeable layer is formed of a second composition containing a rosin component
- an organic hygroscopic agent or an inorganic hygroscopic agent may be shifted.
- acid salts such as acid calcium, magnesium oxide, and acid silica (silica gel)
- metal salts such as calcium carbonate and magnesium sulfate can be preferably used.
- zeolite can be used. These may be in the form of hydrate or anhydride. It is desirable to use magnesium sulfate as the above-mentioned hygroscopic agent from the viewpoint of having an equilibrium humidity suitable for the drug 3 and excellent handleability.
- Magnesium sulfate is preferably used in the form of a hydrate and has a low hydration number in view of the function of the drug packaging bag 1 that absorbs a large amount of water.
- hygroscopic agents are usually used in the form of a powder, but the average particle diameter can be appropriately set within a range of about 4 to 6 ⁇ m.
- the moisture permeable layer 6 constituting the packaging material 2 preferably has a moisture permeability of 40 to 120 gZm 2 Z days.
- PAN is superior in moisture permeability compared to HDPE and the like, so that the moisture permeability in the above range can be achieved more reliably.
- the layer thickness must be extremely thin, and the strength of the moisture permeable layer 6 decreases to a level that cannot be practically used. Then, since the layer thickness can be appropriately secured, the strength of the moisture permeable layer 6 can be effectively secured.
- the shielding layer has at least one kind of force selected from metal foil, polyethylene terephthalate film (PET) and high-density polyethylene (HDPE) layer force.
- Low density polyethylene (LDPE) is superior in water permeability compared to high density resin such as HDPE.
- the shielding layer is made of at least one selected from metal foil, HDPE layer, and PET layer strength, the moisture barrier property is remarkably enhanced.
- the medicine packaging bag 1 is used for a medicine that does not require blocking light of a specific wavelength, it may be formed of a member transparent to the light of the wavelength, but the medicine is effective. From the viewpoint of stably maintaining the components, those having a blocking property to near-infrared light, infrared light, and ultraviolet light are preferable.
- a resin other than LDPE may be used.
- a resin having an appropriate water permeability and excellent dispersibility of the hygroscopic agent examples include polypropylene and ethylene butyrate.
- the moisture absorbing layer can be used as an inflation film together with the intervening layer.
- LDPE, HDPE, PET, etc. having a thickness of about 10 to 30 ⁇ m can be used as the intervening layer.
- the thickness of the shielding layer depends on the material used for the shielding layer, but is usually about 14 to 60 / ⁇ ⁇ , and more preferably 15 to 40 / ⁇ ⁇ . By setting the thickness within the above range, the moisture absorption performance can be achieved more reliably.
- one layer or two or more layers of other layers can be further laminated as necessary.
- adhesive layer, coloring layer, printing layer, vapor deposition layer, brazing Examples include an image layer, a surface protective layer (overcoat layer), and an adhesive layer. These can be the same layers as those used in known packaging materials.
- packaging materials that absorb moisture up to RH 10% may absorb moisture in the space 7 into the packaging material, resulting in a dry state unsuitable for the medicine 3.
- the performance of the medicine 3 may be deteriorated as a result of evaporation of the adhesive component or volatile component contained in the medicine.
- the drug packaging bag 1 shown in Fig. 1 has a structure in which the two moisture permeable layers of the packaging material 2 are laminated so as to be inside.
- the two packaging materials constitute a bag body by being heat-sealed (heat-sealed), leaving a portion that becomes an opening of the medicine packaging bag.
- heat sealing is performed leaving a space (opening) for storing the contents.
- the moisture absorption performance as a packaging material is 25 ° C.
- the equilibrium humidity of this packaging material is RH 40% or more, the moisture present in the internal space of the drug packaging bag is not sufficiently absorbed by the packaging material, and the drug is contained in the drug packaging bag. There exists a tendency for the component in it to precipitate easily.
- the method for producing the packaging drug is not particularly limited.
- the sheet-like (film-like) packaging material 2 is placed on the inside of the moisture permeable layer 6 side so that the patch 3 is sandwiched from both sides.
- the sealing is performed by applying heat to a desired position with a normal sealer or the like (so-called heat sealing), and cutting the outline of the sealing portion as necessary. it can.
- the heat sealing method is not limited to the heat sealing method using a hot plate.
- known methods such as an ultrasonic sealing method and an induction heating sealing method can be widely applied.
- the moisture permeability is in accordance with the moisture permeability test method specified in JIS Z 0208 (1976).
- the permeation cell containing anhydrous calcium chloride is sealed with a film sample (moisture permeability area: 28.274 cm 2 )
- moisture permeability area 28.274 cm 2
- Equilibrium humidity is determined by holding the film-like packaging material (test piece) in a closed space of high humidity (absolute humidity not exceeding the maximum moisture absorption amount of the test piece) at a temperature of 25 ° C. This is the relative humidity when the relative humidity indicated by is in equilibrium. In other words, this is the relative humidity when the moisture absorption / release rate of the specimen is constant and the relative humidity in the sealed space is apparently constant (equilibrium).
- Fabrication of drug packaging bags The following layers are laminated in that order (unless otherwise noted, lamination by a dry laminating method using polyurethane adhesive), and the surface of the shielding layer is covered with cellophane (thickness 20). A packaging material was prepared by coating with ⁇ m).
- Moisture permeable layer PAN (thickness 30 m, moisture permeability 70 gZm 2 Z days)
- LDPE thinness 30 mu m, magnesium sulfate 30 wt 0/0 containing
- Intervening layer 2 LDPE (thickness 20 m)
- Shielding layer Aluminum foil (thickness 9 ⁇ m)
- the equilibrium humidity was RH30% ( ⁇ 5%) at 25 ° C.
- heat-sealing three-sided seal, temperature: 160 ° C, time: 1 second, pressure: 0.
- seal width 10mm
- Intervening layer 1 LDPE (thickness 10 ⁇ m)
- LDPE thinness 30 mu m, magnesium sulfate 42 wt 0/0 containing
- Intervening layer 2 LDPE (thickness 20 m)
- Shielding layer Aluminum foil (thickness 15 m)
- Moisture permeable layer PAN (thickness 30 m, moisture permeability 70 gZm 2 Z days)
- Intervening layer LDPE (thickness 10 m)
- Shielding layer Aluminum foil (thickness 6 m)
- a drug packaging bag was obtained in the same manner as in Example 1 except that LDP E having a thickness of m and a moisture permeability of 60 gZm 2 Z was used instead of the moisture permeable layer of Example 1.
- Moisture adsorption rate (%) ⁇ (measurement result) X 400 ⁇ Z10 6 ⁇ Z maximum adsorption amount X 100
- Methyl salicylate 120, 152
- Carrier gas helium, lmlZmin
- the content of the drug component in the sample solution and the standard solution was measured by the GCZMS.
- a calibration curve was prepared from the measurement results of the standard solution, and the content of the drug component in the sample solution was also calculated as the calibration curve force.
- the sample solution of Conventional Example 1 was diluted 20 times with ethanol. was prepared and remeasured.
- the calculated concentration power of the drug component was also calculated as the amount of adsorption per 100 cm 2 g). The results are shown in Table 1.
Landscapes
- Packages (AREA)
- Wrappers (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Laminated Bodies (AREA)
- Bag Frames (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/304,567 US20090324142A1 (en) | 2006-06-16 | 2007-06-15 | Packaging material and bag for packaging of medicinal product |
JP2008521272A JP5030952B2 (ja) | 2006-06-16 | 2007-06-15 | 薬剤包装用包装材及び薬剤包装用袋 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006-167757 | 2006-06-16 | ||
JP2006167757 | 2006-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007145322A1 true WO2007145322A1 (ja) | 2007-12-21 |
Family
ID=38831835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2007/062123 WO2007145322A1 (ja) | 2006-06-16 | 2007-06-15 | 包装材及び薬剤包装用袋 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20090324142A1 (ja) |
JP (1) | JP5030952B2 (ja) |
WO (1) | WO2007145322A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009160388A (ja) * | 2007-12-14 | 2009-07-23 | Nitto Denko Corp | 貼付剤包装構造 |
JP2009160389A (ja) * | 2007-12-14 | 2009-07-23 | Nitto Denko Corp | 貼付剤包装構造 |
JP2013023230A (ja) * | 2011-07-15 | 2013-02-04 | Hipack Co Ltd | 密閉構造式チャック付き湿分吸収包材 |
JP5208209B2 (ja) * | 2008-05-30 | 2013-06-12 | 日東電工株式会社 | ドネペジル含有貼付製剤およびその包装体 |
JP2014091547A (ja) * | 2012-11-01 | 2014-05-19 | Star Plastic Kogyo Kk | 易開封性包装体用の積層フィルム及び易開封性包装体 |
JP2018115011A (ja) * | 2017-01-18 | 2018-07-26 | 共同印刷株式会社 | 包装袋及びその製造方法 |
JP2020082625A (ja) * | 2018-11-29 | 2020-06-04 | 共同印刷株式会社 | 低吸着性吸湿フィルム |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101588802A (zh) * | 2006-12-01 | 2009-11-25 | 日东电工株式会社 | 含有稳定化的多奈哌齐的贴剂 |
BRPI0719308A2 (pt) * | 2006-12-01 | 2014-02-04 | Nitto Denko Corp | Método para supressão da coloração de preparação adesiva contendo donepzil e método para redução da quantidade de substâncias formadas relacionadas à donepezil. |
JP5421252B2 (ja) * | 2008-05-30 | 2014-02-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 経皮吸収製剤 |
TWI511885B (zh) * | 2009-04-20 | 2015-12-11 | Toyo Aluminium Kk | 積層體、包裝體、包裝用薄片、包裝材料、標籤及容器 |
CL2017002724A1 (es) * | 2017-10-26 | 2018-07-13 | Univ Adolfo Ibanez | Dispositivo que permite controlar los niveles de humedad dentro de un contenedor |
CN111731671A (zh) * | 2020-06-28 | 2020-10-02 | 四川汇利实业有限公司 | 一种液体药品包装袋用复合材料 |
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JPH0539379A (ja) * | 1991-08-08 | 1993-02-19 | Sasaki Kagaku Yakuhin Kk | 調湿性組成物及び調湿性成形品 |
JPH0728550U (ja) * | 1993-11-08 | 1995-05-30 | 積水化学工業株式会社 | 貼付剤用包装袋 |
JP2001009985A (ja) * | 1999-07-02 | 2001-01-16 | Hisamitsu Pharmaceut Co Inc | 貼付剤用包装袋及び包装貼付剤 |
JP2001080004A (ja) * | 1999-09-14 | 2001-03-27 | Sumitomo Chem Co Ltd | 積層フィルムとそれを用いてなる容器 |
WO2005072716A1 (ja) * | 2004-01-30 | 2005-08-11 | Hisamitsu Pharmaceutical Co., Inc. | 貼付剤入り包装袋 |
JP2006044793A (ja) * | 2004-07-01 | 2006-02-16 | Nitto Denko Corp | 貼付材包装体 |
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2007
- 2007-06-15 JP JP2008521272A patent/JP5030952B2/ja not_active Expired - Fee Related
- 2007-06-15 US US12/304,567 patent/US20090324142A1/en not_active Abandoned
- 2007-06-15 WO PCT/JP2007/062123 patent/WO2007145322A1/ja active Application Filing
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JPH0539379A (ja) * | 1991-08-08 | 1993-02-19 | Sasaki Kagaku Yakuhin Kk | 調湿性組成物及び調湿性成形品 |
JPH0728550U (ja) * | 1993-11-08 | 1995-05-30 | 積水化学工業株式会社 | 貼付剤用包装袋 |
JP2001009985A (ja) * | 1999-07-02 | 2001-01-16 | Hisamitsu Pharmaceut Co Inc | 貼付剤用包装袋及び包装貼付剤 |
JP2001080004A (ja) * | 1999-09-14 | 2001-03-27 | Sumitomo Chem Co Ltd | 積層フィルムとそれを用いてなる容器 |
WO2005072716A1 (ja) * | 2004-01-30 | 2005-08-11 | Hisamitsu Pharmaceutical Co., Inc. | 貼付剤入り包装袋 |
JP2006044793A (ja) * | 2004-07-01 | 2006-02-16 | Nitto Denko Corp | 貼付材包装体 |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009160388A (ja) * | 2007-12-14 | 2009-07-23 | Nitto Denko Corp | 貼付剤包装構造 |
JP2009160389A (ja) * | 2007-12-14 | 2009-07-23 | Nitto Denko Corp | 貼付剤包装構造 |
JP5208209B2 (ja) * | 2008-05-30 | 2013-06-12 | 日東電工株式会社 | ドネペジル含有貼付製剤およびその包装体 |
JP2013023230A (ja) * | 2011-07-15 | 2013-02-04 | Hipack Co Ltd | 密閉構造式チャック付き湿分吸収包材 |
JP2014091547A (ja) * | 2012-11-01 | 2014-05-19 | Star Plastic Kogyo Kk | 易開封性包装体用の積層フィルム及び易開封性包装体 |
JP2018115011A (ja) * | 2017-01-18 | 2018-07-26 | 共同印刷株式会社 | 包装袋及びその製造方法 |
JP2020082625A (ja) * | 2018-11-29 | 2020-06-04 | 共同印刷株式会社 | 低吸着性吸湿フィルム |
JP7320938B2 (ja) | 2018-11-29 | 2023-08-04 | 共同印刷株式会社 | 低吸着性吸湿フィルム |
Also Published As
Publication number | Publication date |
---|---|
JPWO2007145322A1 (ja) | 2009-11-12 |
JP5030952B2 (ja) | 2012-09-19 |
US20090324142A1 (en) | 2009-12-31 |
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