WO2007134181A3 - 5'-modified bicyclic nucleic acid analogs - Google Patents
5'-modified bicyclic nucleic acid analogs Download PDFInfo
- Publication number
- WO2007134181A3 WO2007134181A3 PCT/US2007/068690 US2007068690W WO2007134181A3 WO 2007134181 A3 WO2007134181 A3 WO 2007134181A3 US 2007068690 W US2007068690 W US 2007068690W WO 2007134181 A3 WO2007134181 A3 WO 2007134181A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- acid analogs
- nucleoside analogs
- bicyclic nucleic
- modified bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2007249349A AU2007249349B2 (en) | 2006-05-11 | 2007-05-10 | 5'-Modified bicyclic nucleic acid analogs |
CA2651453A CA2651453C (en) | 2006-05-11 | 2007-05-10 | 5'-modified bicyclic nucleic acid analogs |
DK07797414.5T DK2066684T3 (en) | 2006-05-11 | 2007-05-10 | 5'-Modified Bicyclic Nucleic Acid Analogs |
EP07797414A EP2066684B1 (en) | 2006-05-11 | 2007-05-10 | 5'-modified bicyclic nucleic acid analogs |
CN2007800262854A CN101490074B (en) | 2006-05-11 | 2007-05-10 | 5'-modified bicyclic nucleic acid analogs |
ES07797414T ES2389737T3 (en) | 2006-05-11 | 2007-05-10 | 5 'modified bicyclic nucleic acid analogs |
JP2009510176A JP5441688B2 (en) | 2006-05-11 | 2007-05-10 | 5 'modified bicyclic nucleic acid analogs |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74705906P | 2006-05-11 | 2006-05-11 | |
US60/747,059 | 2006-05-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007134181A2 WO2007134181A2 (en) | 2007-11-22 |
WO2007134181A3 true WO2007134181A3 (en) | 2008-01-10 |
Family
ID=38686833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/068690 WO2007134181A2 (en) | 2006-05-11 | 2007-05-10 | 5'-modified bicyclic nucleic acid analogs |
Country Status (9)
Country | Link |
---|---|
US (4) | US7547684B2 (en) |
EP (1) | EP2066684B1 (en) |
JP (1) | JP5441688B2 (en) |
CN (1) | CN101490074B (en) |
AU (1) | AU2007249349B2 (en) |
CA (1) | CA2651453C (en) |
DK (1) | DK2066684T3 (en) |
ES (1) | ES2389737T3 (en) |
WO (1) | WO2007134181A2 (en) |
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US8846637B2 (en) | 2010-06-08 | 2014-09-30 | Isis Pharmaceuticals, Inc. | Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom |
US8883752B2 (en) | 2008-10-24 | 2014-11-11 | Isis Pharmaceuticals, Inc. | 5′ and 2′ BIS-substituted nucleosides and oligomeric compounds prepared therefrom |
US8916694B2 (en) | 2004-05-05 | 2014-12-23 | Genzyme Corporation | SNPs of apolipoprotein B and modulation of their expression |
US8957200B2 (en) | 2010-06-07 | 2015-02-17 | Isis Pharmaceuticals, Inc. | Bicyclic nucleosides and oligomeric compounds prepared therefrom |
US8987435B2 (en) | 2008-10-24 | 2015-03-24 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and methods |
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US8993738B2 (en) | 2010-04-28 | 2015-03-31 | Isis Pharmaceuticals, Inc. | Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom |
US9005906B2 (en) | 2007-08-15 | 2015-04-14 | Isis Pharmaceuticals, Inc. | Tetrahydropyran nucleic acid analogs |
US9012421B2 (en) | 2009-08-06 | 2015-04-21 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
US9107933B2 (en) | 2009-03-16 | 2015-08-18 | Isis Pharmaceuticals, Inc. | Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III |
US9127276B2 (en) | 2013-05-01 | 2015-09-08 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
US9156873B2 (en) | 2010-04-28 | 2015-10-13 | Isis Pharmaceuticals, Inc. | Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom |
US9175291B2 (en) | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
US9221864B2 (en) | 2012-04-09 | 2015-12-29 | Isis Pharmaceuticals, Inc. | Tricyclic nucleic acid analogs |
US9347061B2 (en) | 2007-03-24 | 2016-05-24 | Genzyme Corporation | Administering antisense oligonucleotides complementary to human apolipoprotein B |
US9382540B2 (en) | 2014-05-01 | 2016-07-05 | Isis Pharmaceuticals, Inc | Compositions and methods for modulating angiopoietin-like 3 expression |
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US11852627B2 (en) | 2015-11-12 | 2023-12-26 | Hoffmann-La Roche Inc. | Oligonucleotides for inducing paternal UBE3A expression |
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CN101490074A (en) | 2009-07-22 |
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US20090192302A1 (en) | 2009-07-30 |
US20070287831A1 (en) | 2007-12-13 |
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US8030467B2 (en) | 2011-10-04 |
US7547684B2 (en) | 2009-06-16 |
US8268980B2 (en) | 2012-09-18 |
CA2651453C (en) | 2014-10-14 |
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ES2389737T3 (en) | 2012-10-31 |
JP2009536955A (en) | 2009-10-22 |
JP5441688B2 (en) | 2014-03-12 |
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CN101490074B (en) | 2013-06-26 |
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