WO2006133006A3 - 1-methyl-1h-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents - Google Patents

1-methyl-1h-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents Download PDF

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Publication number
WO2006133006A3
WO2006133006A3 PCT/US2006/021550 US2006021550W WO2006133006A3 WO 2006133006 A3 WO2006133006 A3 WO 2006133006A3 US 2006021550 W US2006021550 W US 2006021550W WO 2006133006 A3 WO2006133006 A3 WO 2006133006A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrazole
methyl
chemotherapeutic agents
cancer chemotherapeutic
carboxamides useful
Prior art date
Application number
PCT/US2006/021550
Other languages
French (fr)
Other versions
WO2006133006A2 (en
Inventor
Philip Wickens
Harold C E Kluender
Zhenqiu Hong
Ellalahewage Sath Kumarasinghe
Charles Kreiman
Mingbao Zhang
Istvan Enyedy
Chih-Yuan Chuang
Original Assignee
Bayer Pharmaceuticals Corp
Philip Wickens
Harold C E Kluender
Zhenqiu Hong
Ellalahewage Sath Kumarasinghe
Charles Kreiman
Mingbao Zhang
Istvan Enyedy
Chih-Yuan Chuang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp, Philip Wickens, Harold C E Kluender, Zhenqiu Hong, Ellalahewage Sath Kumarasinghe, Charles Kreiman, Mingbao Zhang, Istvan Enyedy, Chih-Yuan Chuang filed Critical Bayer Pharmaceuticals Corp
Priority to JP2008514922A priority Critical patent/JP2008545756A/en
Priority to CA002610509A priority patent/CA2610509A1/en
Priority to EP06772019A priority patent/EP1891047A4/en
Publication of WO2006133006A2 publication Critical patent/WO2006133006A2/en
Publication of WO2006133006A3 publication Critical patent/WO2006133006A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

This invention relates to novel 1 -Methyl- lH-pyrazole-4-carboxamide compounds, pharmaceutical compositions containing such compounds, and the use of those compounds or compositions as cancer chemotherapeutic agents.
PCT/US2006/021550 2005-06-03 2006-06-02 1-methyl-1h-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents WO2006133006A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008514922A JP2008545756A (en) 2005-06-03 2006-06-02 1-methyl-1H-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents
CA002610509A CA2610509A1 (en) 2005-06-03 2006-06-02 1-methyl-1h-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents
EP06772019A EP1891047A4 (en) 2005-06-03 2006-06-02 1-methyl-1h-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68745405P 2005-06-03 2005-06-03
US60/687,454 2005-06-03

Publications (2)

Publication Number Publication Date
WO2006133006A2 WO2006133006A2 (en) 2006-12-14
WO2006133006A3 true WO2006133006A3 (en) 2007-02-22

Family

ID=37498955

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/021550 WO2006133006A2 (en) 2005-06-03 2006-06-02 1-methyl-1h-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents

Country Status (4)

Country Link
EP (1) EP1891047A4 (en)
JP (1) JP2008545756A (en)
CA (1) CA2610509A1 (en)
WO (1) WO2006133006A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9340555B2 (en) 2009-09-03 2016-05-17 Allergan, Inc. Compounds as tyrosine kinase modulators
SG178963A1 (en) * 2009-09-03 2012-04-27 Allergan Inc Compounds as tyrosine kinase modulators
US9546165B2 (en) * 2009-10-06 2017-01-17 Sunesis Pharmaceuticals, Inc. Heterocyclic compounds useful as PDK1 inhibitors
EP2788349B1 (en) 2011-12-09 2016-10-26 Chiesi Farmaceutici S.p.A. Kinase inhibitors
JP6145849B2 (en) 2011-12-09 2017-06-14 チエシ ファルマスーティシ エス．ピー．エー． Kinase inhibitor
KR20160018567A (en) 2013-06-06 2016-02-17 키에시 파르마슈티시 엣스. 피. 에이. Kinase inhibitors
AR105955A1 (en) * 2015-09-08 2017-11-29 Santen Pharmaceutical Co Ltd METHOD FOR PRODUCING A PYRIDINACARBOXAMIDE
EP3692045A1 (en) 2017-10-04 2020-08-12 Bayer Aktiengesellschaft Derivatives of heterocyclic compounds as pest control agents
ES2929476T3 (en) 2018-03-12 2022-11-29 Bayer Ag Condensed bicyclic heterocyclic derivatives as pesticides
JP2021522182A (en) 2018-04-20 2021-08-30 バイエル・アクチエンゲゼルシヤフト Heterocyclene derivative as a pesticide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838458B2 (en) * 2001-11-02 2005-01-04 Pfizer, Inc. 5-(alkylidene-cycloalkyl)-and 5-(alkylidene-heterocyclyl)-pyrazoles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838458B2 (en) * 2001-11-02 2005-01-04 Pfizer, Inc. 5-(alkylidene-cycloalkyl)-and 5-(alkylidene-heterocyclyl)-pyrazoles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1891047A4 *

Also Published As

Publication number Publication date
EP1891047A2 (en) 2008-02-27
JP2008545756A (en) 2008-12-18
EP1891047A4 (en) 2008-07-09
WO2006133006A2 (en) 2006-12-14
CA2610509A1 (en) 2006-12-14

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