WO2007075963A3 - Systems and methods for the delivery of corticosteroids - Google Patents
Systems and methods for the delivery of corticosteroids Download PDFInfo
- Publication number
- WO2007075963A3 WO2007075963A3 PCT/US2006/048927 US2006048927W WO2007075963A3 WO 2007075963 A3 WO2007075963 A3 WO 2007075963A3 US 2006048927 W US2006048927 W US 2006048927W WO 2007075963 A3 WO2007075963 A3 WO 2007075963A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- delivery
- corticosteroid
- systems
- methods
- inhalable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
Abstract
The present invention relates to methods and systems for the delivery of a corticosteroid comprising (1) an inhalable aqueous mixture comprising a corticosteroid and a solubility enhancer and (2) an inhalable nebulizer, wherein the delivery of the aqueous mixture comprising the corticosteroid by the nebulizer results in an enhanced pharmacokinetic profile of the corticosteroid as compared to conventional inhalable therapies and/or increase lung deposition.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008547580A JP2009520828A (en) | 2005-12-20 | 2006-12-19 | Systems and methods for delivering corticosteroids |
EP06845981A EP1971346A2 (en) | 2005-12-20 | 2006-12-19 | Systems and methods for the delivery of corticosteroids |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75273505P | 2005-12-20 | 2005-12-20 | |
US75276505P | 2005-12-20 | 2005-12-20 | |
US75233205P | 2005-12-20 | 2005-12-20 | |
US77399906P | 2006-02-15 | 2006-02-15 | |
US77399806P | 2006-02-15 | 2006-02-15 | |
US82009206P | 2006-07-21 | 2006-07-21 | |
US82009406P | 2006-07-21 | 2006-07-21 | |
US82009606P | 2006-07-21 | 2006-07-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007075963A2 WO2007075963A2 (en) | 2007-07-05 |
WO2007075963A3 true WO2007075963A3 (en) | 2008-11-27 |
Family
ID=38218568
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/048630 WO2007075800A2 (en) | 2005-12-20 | 2006-12-19 | Methods and systems for the delivery of corticosteroids |
PCT/US2006/048629 WO2007075799A2 (en) | 2005-12-20 | 2006-12-19 | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
PCT/US2006/048735 WO2007075859A2 (en) | 2005-12-20 | 2006-12-19 | Systems and methods for the delivery of corticosteroids having an increased lung deposition |
PCT/US2006/048628 WO2007075798A2 (en) | 2005-12-20 | 2006-12-19 | Methods and systems for the delivery of corticosteroids having an increased lung deposition |
PCT/US2006/048927 WO2007075963A2 (en) | 2005-12-20 | 2006-12-19 | Systems and methods for the delivery of corticosteroids |
PCT/US2006/048631 WO2007075801A2 (en) | 2005-12-20 | 2006-12-19 | Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/048630 WO2007075800A2 (en) | 2005-12-20 | 2006-12-19 | Methods and systems for the delivery of corticosteroids |
PCT/US2006/048629 WO2007075799A2 (en) | 2005-12-20 | 2006-12-19 | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
PCT/US2006/048735 WO2007075859A2 (en) | 2005-12-20 | 2006-12-19 | Systems and methods for the delivery of corticosteroids having an increased lung deposition |
PCT/US2006/048628 WO2007075798A2 (en) | 2005-12-20 | 2006-12-19 | Methods and systems for the delivery of corticosteroids having an increased lung deposition |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/048631 WO2007075801A2 (en) | 2005-12-20 | 2006-12-19 | Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
Country Status (5)
Country | Link |
---|---|
EP (6) | EP1971346A2 (en) |
JP (6) | JP2009520822A (en) |
BR (1) | BRPI0620225A2 (en) |
CA (2) | CA2634413A1 (en) |
WO (6) | WO2007075800A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
CN101911139B (en) * | 2007-11-16 | 2013-03-20 | 粒子监测系统有限公司 | System and method for calibration verification of an optical particle counter |
US20120022032A1 (en) * | 2008-10-10 | 2012-01-26 | Schering Corporation | Corticosteroid compositions and methods of treatments thereof |
CA2934961A1 (en) * | 2014-01-17 | 2015-07-23 | Nephron Pharmaceuticals Corporation | Budesonide cyclodextrin formulation |
EP4122469A1 (en) * | 2014-03-28 | 2023-01-25 | Paul Maes | Composition comprising cyclodextrin and budesonide derivatives for the treatment and prophylaxis of pulmonary inflammations |
EP2923702A1 (en) * | 2014-03-28 | 2015-09-30 | Universite De Liege | Composition of cyclodextrin with budesonide derivatives for treatment and prevention of pulmonary inflammatory disease |
WO2019217286A1 (en) | 2018-05-07 | 2019-11-14 | Prana Biosciences Inc | Metaxalone formulations |
AU2020204925A1 (en) | 2019-01-03 | 2021-07-22 | Cyclarity Therapeutics, Inc. | Cyclodextrin dimers, compositions thereof, and uses thereof |
CN113491677B (en) * | 2020-03-18 | 2023-09-26 | 南京知和医药科技有限公司 | Novel medicinal antiviral drug inhalant preparation and preparation method thereof |
WO2022217029A1 (en) * | 2021-04-09 | 2022-10-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for delivering pharmaceutical agents |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5192528A (en) * | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
US20040228805A1 (en) * | 2002-08-17 | 2004-11-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic |
US20050065141A1 (en) * | 2003-07-31 | 2005-03-24 | Odink Debra A. | Carbapenems useful in treating and preventing pulmonary infections, pharmaceutical compositions thereof and modes of administration thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
US6598603B1 (en) * | 1997-12-31 | 2003-07-29 | Astra Aktiebolag | Method for treating respiratory diseases |
US20020183292A1 (en) * | 2000-10-31 | 2002-12-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and corticosteroids |
GB0029562D0 (en) * | 2000-12-04 | 2001-01-17 | Novartis Ag | Organic compounds |
WO2002060896A1 (en) * | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
WO2002074200A1 (en) * | 2001-03-20 | 2002-09-26 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
US20030055026A1 (en) * | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
EP3470084A1 (en) * | 2002-12-09 | 2019-04-17 | Abraxis BioScience, LLC | Compositions and methods of delivery of pharmacological agents |
AU2004292445B2 (en) * | 2003-11-21 | 2010-02-04 | Zalicus Inc. | Methods and reagents for the treatment of inflammatory disorders |
AU2004311478A1 (en) * | 2003-12-31 | 2005-07-21 | Cydex Pharmaceuticals, Inc. | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
-
2006
- 2006-12-19 WO PCT/US2006/048630 patent/WO2007075800A2/en active Application Filing
- 2006-12-19 CA CA002634413A patent/CA2634413A1/en not_active Abandoned
- 2006-12-19 EP EP06845981A patent/EP1971346A2/en not_active Withdrawn
- 2006-12-19 JP JP2008547497A patent/JP2009520822A/en not_active Withdrawn
- 2006-12-19 WO PCT/US2006/048629 patent/WO2007075799A2/en active Application Filing
- 2006-12-19 EP EP06845904A patent/EP1971345A2/en not_active Withdrawn
- 2006-12-19 EP EP06847888A patent/EP1971348A2/en not_active Withdrawn
- 2006-12-19 CA CA002634398A patent/CA2634398A1/en not_active Abandoned
- 2006-12-19 JP JP2008547580A patent/JP2009520828A/en not_active Withdrawn
- 2006-12-19 JP JP2008547496A patent/JP2009524590A/en not_active Withdrawn
- 2006-12-19 JP JP2008547495A patent/JP2009520821A/en not_active Withdrawn
- 2006-12-19 WO PCT/US2006/048735 patent/WO2007075859A2/en active Application Filing
- 2006-12-19 JP JP2008547498A patent/JP2009520823A/en not_active Withdrawn
- 2006-12-19 JP JP2008547534A patent/JP2009520827A/en not_active Withdrawn
- 2006-12-19 WO PCT/US2006/048628 patent/WO2007075798A2/en active Application Filing
- 2006-12-19 BR BRPI0620225-0A patent/BRPI0620225A2/en not_active Application Discontinuation
- 2006-12-19 EP EP06848786A patent/EP1971349A2/en not_active Withdrawn
- 2006-12-19 WO PCT/US2006/048927 patent/WO2007075963A2/en active Application Filing
- 2006-12-19 EP EP06847837A patent/EP1973550A2/en not_active Withdrawn
- 2006-12-19 WO PCT/US2006/048631 patent/WO2007075801A2/en active Application Filing
- 2006-12-19 EP EP06847838A patent/EP1971347A2/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5192528A (en) * | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
US20040228805A1 (en) * | 2002-08-17 | 2004-11-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic |
US20050065141A1 (en) * | 2003-07-31 | 2005-03-24 | Odink Debra A. | Carbapenems useful in treating and preventing pulmonary infections, pharmaceutical compositions thereof and modes of administration thereof |
Non-Patent Citations (1)
Title |
---|
GESSLER ET AL.: "Ultrasonic versus jet nebulization of iloprost in several pulmonary ypertension?", EUROPEAN RESPIRATORY JOURNAL, vol. 17, 2001, pages 14 - 19, XP008129043 * |
Also Published As
Publication number | Publication date |
---|---|
EP1971346A2 (en) | 2008-09-24 |
WO2007075963A2 (en) | 2007-07-05 |
JP2009520828A (en) | 2009-05-28 |
JP2009524590A (en) | 2009-07-02 |
JP2009520822A (en) | 2009-05-28 |
EP1971348A2 (en) | 2008-09-24 |
EP1973550A2 (en) | 2008-10-01 |
WO2007075798A9 (en) | 2007-08-23 |
EP1971347A2 (en) | 2008-09-24 |
WO2007075799A2 (en) | 2007-07-05 |
WO2007075801A2 (en) | 2007-07-05 |
WO2007075859A2 (en) | 2007-07-05 |
EP1971349A2 (en) | 2008-09-24 |
BRPI0620225A2 (en) | 2011-11-01 |
JP2009520827A (en) | 2009-05-28 |
WO2007075800A2 (en) | 2007-07-05 |
WO2007075799A3 (en) | 2009-01-15 |
WO2007075859A3 (en) | 2008-12-11 |
JP2009520823A (en) | 2009-05-28 |
WO2007075800A3 (en) | 2008-11-20 |
WO2007075798A3 (en) | 2008-11-20 |
WO2007075801A3 (en) | 2008-12-31 |
WO2007075798A2 (en) | 2007-07-05 |
CA2634413A1 (en) | 2007-07-05 |
JP2009520821A (en) | 2009-05-28 |
CA2634398A1 (en) | 2007-07-05 |
EP1971345A2 (en) | 2008-09-24 |
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