WO2007075801A3 - Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile - Google Patents

Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile Download PDF

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Publication number
WO2007075801A3
WO2007075801A3 PCT/US2006/048631 US2006048631W WO2007075801A3 WO 2007075801 A3 WO2007075801 A3 WO 2007075801A3 US 2006048631 W US2006048631 W US 2006048631W WO 2007075801 A3 WO2007075801 A3 WO 2007075801A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
corticosteroid
pharmacokinetic profile
corticosteroids
enhanced pharmacokinetic
Prior art date
Application number
PCT/US2006/048631
Other languages
French (fr)
Other versions
WO2007075801A2 (en
Inventor
Malcolm R Hill
Original Assignee
Tika Laekemedel Ab
Malcolm R Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tika Laekemedel Ab, Malcolm R Hill filed Critical Tika Laekemedel Ab
Priority to CA002634413A priority Critical patent/CA2634413A1/en
Priority to BRPI0620154-7A priority patent/BRPI0620154A2/en
Priority to JP2008547498A priority patent/JP2009520823A/en
Priority to EP06845904A priority patent/EP1971345A2/en
Publication of WO2007075801A2 publication Critical patent/WO2007075801A2/en
Publication of WO2007075801A3 publication Critical patent/WO2007075801A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to methods and systems for the delivery of a corticosteroid comprising (1) an inhalable aqueous mixture comprising a corticosteroid and a solubility enhancer and (2) an inhalable nebulizer, wherein the delivery of the aqueous mixture comprising the corticosteroid by the nebulizer results in an enhanced pharmacokinetic profile of the corticosteroid as compared to conventional inhalable therapies and/or increased lung deposition.
PCT/US2006/048631 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile WO2007075801A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002634413A CA2634413A1 (en) 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile
BRPI0620154-7A BRPI0620154A2 (en) 2005-12-20 2006-12-19 method and system for corticosteroid distribution having an improved pharmacokinetic profile
JP2008547498A JP2009520823A (en) 2005-12-20 2006-12-19 Methods and systems for delivering corticosteroids with improved pharmacokinetic profiles
EP06845904A EP1971345A2 (en) 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US75233205P 2005-12-20 2005-12-20
US75276505P 2005-12-20 2005-12-20
US75273505P 2005-12-20 2005-12-20
US60/752,735 2005-12-20
US60/752,765 2005-12-20
US60/752,332 2005-12-20
US77399906P 2006-02-15 2006-02-15
US77399806P 2006-02-15 2006-02-15
US60/773,998 2006-02-15
US60/773,999 2006-02-15
US82009606P 2006-07-21 2006-07-21
US82009206P 2006-07-21 2006-07-21
US82009406P 2006-07-21 2006-07-21
US60/820,092 2006-07-21
US60/820,096 2006-07-21
US60/820,094 2006-07-21

Publications (2)

Publication Number Publication Date
WO2007075801A2 WO2007075801A2 (en) 2007-07-05
WO2007075801A3 true WO2007075801A3 (en) 2008-12-31

Family

ID=38218568

Family Applications (6)

Application Number Title Priority Date Filing Date
PCT/US2006/048628 WO2007075798A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048927 WO2007075963A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids
PCT/US2006/048631 WO2007075801A2 (en) 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048629 WO2007075799A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048735 WO2007075859A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048630 WO2007075800A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2006/048628 WO2007075798A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048927 WO2007075963A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids

Family Applications After (3)

Application Number Title Priority Date Filing Date
PCT/US2006/048629 WO2007075799A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048735 WO2007075859A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048630 WO2007075800A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids

Country Status (5)

Country Link
EP (6) EP1973550A2 (en)
JP (6) JP2009520822A (en)
BR (1) BRPI0620225A2 (en)
CA (2) CA2634398A1 (en)
WO (6) WO2007075798A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US7973929B2 (en) * 2007-11-16 2011-07-05 Particle Measuring Systems, Inc. System and method for calibration verification of an optical particle counter
AU2009302362A1 (en) * 2008-10-10 2010-04-15 Merck Sharp & Dohme Corp. Corticosteroid compositions for use in treating diseases of the upper and lower airway passages
CA2934961A1 (en) * 2014-01-17 2015-07-23 Nephron Pharmaceuticals Corporation Budesonide cyclodextrin formulation
ES2942710T3 (en) * 2014-03-28 2023-06-06 Univ Liege Composition comprising cyclodextrin and budesonide derivatives for use in the treatment and prophylaxis of pulmonary inflammations
EP2923702A1 (en) * 2014-03-28 2015-09-30 Universite De Liege Composition of cyclodextrin with budesonide derivatives for treatment and prevention of pulmonary inflammatory disease
US11672781B2 (en) 2018-05-07 2023-06-13 Prana Biosciences Inc Metaxalone formulations
EP3906263A4 (en) 2019-01-03 2022-08-31 Underdog Pharmaceuticals, Inc. Cyclodextrin dimers, compositions thereof, and uses thereof
CN113491677B (en) * 2020-03-18 2023-09-26 南京知和医药科技有限公司 Novel medicinal antiviral drug inhalant preparation and preparation method thereof
WO2022217029A1 (en) * 2021-04-09 2022-10-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for delivering pharmaceutical agents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004002A1 (en) * 2002-12-09 2005-01-06 American Bioscience, Inc. Compositions and methods of delivery of pharmacological agents
WO2005065435A2 (en) * 2003-12-31 2005-07-21 Cydex, Inc. Et Al. Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US20050187203A1 (en) * 2003-11-21 2005-08-25 Jost-Price Edward R. Methods and reagents for the treatment of inflammatory disorders

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
GB0029562D0 (en) * 2000-12-04 2001-01-17 Novartis Ag Organic compounds
DE60113731T2 (en) * 2001-01-31 2006-06-29 Pfizer Products Inc., Groton ETHER DERIVATIVES SUITABLE AS INHIBITORS OF PDE4 ISOZYME
JP4334229B2 (en) * 2001-03-20 2009-09-30 サイデックス・ファーマシューティカルズ・インコーポレイテッド Formulation containing propofol and sulfoalkyl ether cyclodextrin
US20030055026A1 (en) * 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US7244742B2 (en) * 2002-08-17 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
US20050065141A1 (en) * 2003-07-31 2005-03-24 Odink Debra A. Carbapenems useful in treating and preventing pulmonary infections, pharmaceutical compositions thereof and modes of administration thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004002A1 (en) * 2002-12-09 2005-01-06 American Bioscience, Inc. Compositions and methods of delivery of pharmacological agents
US20050187203A1 (en) * 2003-11-21 2005-08-25 Jost-Price Edward R. Methods and reagents for the treatment of inflammatory disorders
WO2005065435A2 (en) * 2003-12-31 2005-07-21 Cydex, Inc. Et Al. Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid

Also Published As

Publication number Publication date
WO2007075798A9 (en) 2007-08-23
WO2007075798A3 (en) 2008-11-20
JP2009524590A (en) 2009-07-02
WO2007075963A3 (en) 2008-11-27
EP1973550A2 (en) 2008-10-01
EP1971349A2 (en) 2008-09-24
WO2007075799A2 (en) 2007-07-05
JP2009520823A (en) 2009-05-28
WO2007075859A2 (en) 2007-07-05
BRPI0620225A2 (en) 2011-11-01
WO2007075800A3 (en) 2008-11-20
WO2007075859A3 (en) 2008-12-11
JP2009520822A (en) 2009-05-28
WO2007075799A3 (en) 2009-01-15
JP2009520828A (en) 2009-05-28
WO2007075801A2 (en) 2007-07-05
EP1971347A2 (en) 2008-09-24
EP1971348A2 (en) 2008-09-24
CA2634413A1 (en) 2007-07-05
EP1971345A2 (en) 2008-09-24
WO2007075800A2 (en) 2007-07-05
WO2007075798A2 (en) 2007-07-05
CA2634398A1 (en) 2007-07-05
EP1971346A2 (en) 2008-09-24
WO2007075963A2 (en) 2007-07-05
JP2009520827A (en) 2009-05-28
JP2009520821A (en) 2009-05-28

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