WO2006042858A3 - Complex comprising an antibiotic, a cyclodextrin and an interaction agent - Google Patents

Complex comprising an antibiotic, a cyclodextrin and an interaction agent Download PDF

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Publication number
WO2006042858A3
WO2006042858A3 PCT/EP2005/055389 EP2005055389W WO2006042858A3 WO 2006042858 A3 WO2006042858 A3 WO 2006042858A3 EP 2005055389 W EP2005055389 W EP 2005055389W WO 2006042858 A3 WO2006042858 A3 WO 2006042858A3
Authority
WO
WIPO (PCT)
Prior art keywords
complex
antibiotic
cyclodextrin
interaction agent
advantageously
Prior art date
Application number
PCT/EP2005/055389
Other languages
French (fr)
Other versions
WO2006042858A2 (en
Inventor
Bernard Freiss
Hubert Lochard
Original Assignee
Pf Medicament
Bernard Freiss
Hubert Lochard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament, Bernard Freiss, Hubert Lochard filed Critical Pf Medicament
Publication of WO2006042858A2 publication Critical patent/WO2006042858A2/en
Publication of WO2006042858A3 publication Critical patent/WO2006042858A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a complex comprising an antibiotic selected from the group of macrolides, a cyclodextrin and an interaction agent characterized in that the solubilization rate of the complexed antibiotic in water measured for a solution of 10g/l antibiotic in water at room temperature after 5 - 120 minutes of agitation is more than 20 %, advantageously more than 40 % and advantageously more than à 60 % at a pH of 9. The invention also relates to a method for the preparation of said complex and an aqueous formulation containing said complex.
PCT/EP2005/055389 2004-10-21 2005-10-19 Complex comprising an antibiotic, a cyclodextrin and an interaction agent WO2006042858A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0411200A FR2876914A1 (en) 2004-10-21 2004-10-21 COMPLEX COMPRISING AN ANTIBIOTICS, A CYCLODEXTRIN AND AN INTERACTION AGENT
FR0411200 2004-10-21

Publications (2)

Publication Number Publication Date
WO2006042858A2 WO2006042858A2 (en) 2006-04-27
WO2006042858A3 true WO2006042858A3 (en) 2006-07-20

Family

ID=34952492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/055389 WO2006042858A2 (en) 2004-10-21 2005-10-19 Complex comprising an antibiotic, a cyclodextrin and an interaction agent

Country Status (2)

Country Link
FR (1) FR2876914A1 (en)
WO (1) WO2006042858A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2944280B1 (en) * 2009-04-09 2012-08-03 Galderma Res & Dev PROCESS FOR THE PREPARATION OF MOLECULAR COMPLEXES BETWEEN ADAPALENE AND CYCLODEXTRINS
CA2822995C (en) * 2010-12-31 2021-05-11 Eastpond Laboratories Limited Cellular hydration compositions containing cyclodextrins
US20120171184A1 (en) 2010-12-31 2012-07-05 Lajos Szente Cellular hydration compositions
ES2899756T3 (en) * 2013-03-12 2022-03-14 Primal Therapies Inc Dental composition comprising chelator and base

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920006911B1 (en) * 1989-06-14 1992-08-22 신풍제약 주식회사 Process for preparing stablized injectable piroxicam composition
US5472954A (en) * 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
WO2002032459A2 (en) * 2000-10-17 2002-04-25 Massachusetts Institute Of Technology Method of increasing the efficacy of antibiotics by complexing with cyclodextrins
FR2815540A1 (en) * 2000-10-19 2002-04-26 Separex Sa A method and apparatus for making very fine particles containing a complex of an active principle and a cyclodextrin for e.g. pharmaceutical use by placing them in a solvent or solvents and contacting with a supercritical liquid
WO2002089851A1 (en) * 2001-03-06 2002-11-14 Separex (Societe Anonyme) Method for making host-client complexes
FR2830760A1 (en) * 2001-10-12 2003-04-18 Pf Medicament New process to complex active materials with a solid support in order to improve water solubility, using a supercritical fluid
WO2003095498A1 (en) * 2002-05-10 2003-11-20 Yunqing Liu Complex of organic medicines and beta-cyclodextrin derivatives and its preparing process
FR2854079A1 (en) * 2003-04-25 2004-10-29 Pf Medicament Preparation of soluble molecular complexes, useful for delivering e.g. pharmaceuticals, by molecular diffusion of active agents into host molecules in presence of diffusion agent
CN1562063A (en) * 2004-03-17 2005-01-12 陕西省微生物研究所 Medicinal preparation containing erythromycine ethylsuccinate
WO2005097201A2 (en) * 2004-04-01 2005-10-20 Pierre Fabre Medicament Inclusion complexes containing piroxicam, a cyclodextrin and arginine
WO2005112637A1 (en) * 2004-05-14 2005-12-01 Decode Chemistry, Inc. Formulations for non-parenteral use including hydrophobic cyclodextrins

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920006911B1 (en) * 1989-06-14 1992-08-22 신풍제약 주식회사 Process for preparing stablized injectable piroxicam composition
US5472954A (en) * 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
WO2002032459A2 (en) * 2000-10-17 2002-04-25 Massachusetts Institute Of Technology Method of increasing the efficacy of antibiotics by complexing with cyclodextrins
FR2815540A1 (en) * 2000-10-19 2002-04-26 Separex Sa A method and apparatus for making very fine particles containing a complex of an active principle and a cyclodextrin for e.g. pharmaceutical use by placing them in a solvent or solvents and contacting with a supercritical liquid
WO2002089851A1 (en) * 2001-03-06 2002-11-14 Separex (Societe Anonyme) Method for making host-client complexes
FR2830760A1 (en) * 2001-10-12 2003-04-18 Pf Medicament New process to complex active materials with a solid support in order to improve water solubility, using a supercritical fluid
WO2003095498A1 (en) * 2002-05-10 2003-11-20 Yunqing Liu Complex of organic medicines and beta-cyclodextrin derivatives and its preparing process
EP1514877A1 (en) * 2002-05-10 2005-03-16 Yunqing Liu Complex of organic medicines and beta-cyclodextrin derivatives and its preparing process
FR2854079A1 (en) * 2003-04-25 2004-10-29 Pf Medicament Preparation of soluble molecular complexes, useful for delivering e.g. pharmaceuticals, by molecular diffusion of active agents into host molecules in presence of diffusion agent
CN1562063A (en) * 2004-03-17 2005-01-12 陕西省微生物研究所 Medicinal preparation containing erythromycine ethylsuccinate
WO2005097201A2 (en) * 2004-04-01 2005-10-20 Pierre Fabre Medicament Inclusion complexes containing piroxicam, a cyclodextrin and arginine
WO2005112637A1 (en) * 2004-05-14 2005-12-01 Decode Chemistry, Inc. Formulations for non-parenteral use including hydrophobic cyclodextrins

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CSERHATI, TIBOR ET AL: "Interaction of some antibiotics with hydroxypropyl-.beta.- cyclodextrin", JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY , 18(3), 265-74 CODEN: JIMCEN; ISSN: 0923-0750, 1994, XP008063855 *
DATABASE WPI Section Ch Week 199312, Derwent World Patents Index; Class A96, AN 1993-098122, XP002375837 *
DATABASE WPI Section Ch Week 200532, Derwent World Patents Index; Class B02, AN 2005-306970, XP002379930 *
HEES VAN T ET AL: "APPLICATION OF SUPERCRITICAL CARBON DIOXIDE FOR THE PREPARATION OF A PIROXICAM-BETA-CYCLODEXTRIN INCLUSION COMPOUND", PHARMACOLOGICAL RESEARCH, ACADEMIC PRESS, LONDON, GB, vol. 16, no. 12, 1999, pages 1864 - 1870, XP008006992, ISSN: 1043-6618 *
HEES VAN T ET AL: "APPLICATION OF SUPERCRITICAL CARBON DIOXIDE FOR THE PREPARATION OF DRUG-CYCLODEXTRIN INCLUSION COMPOUNDS", JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, KLUWER, DORDRECHT, NL, vol. 44, 2002, pages 271 - 274, XP008040794, ISSN: 1388-3127 *
MURA P ET AL: "TERNARY SYSTEMS OF NAPROXEN WITH HYDROXYPROPYL-BETA-CYCLODEXTRIN AND AMINOACIDS", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 260, no. 2, 24 July 2003 (2003-07-24), pages 293 - 302, XP008062550, ISSN: 0378-5173 *

Also Published As

Publication number Publication date
WO2006042858A2 (en) 2006-04-27
FR2876914A1 (en) 2006-04-28

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