WO2005070464A3 - A tablet formulation of clopidogrel bisulphate - Google Patents

A tablet formulation of clopidogrel bisulphate Download PDF

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Publication number
WO2005070464A3
WO2005070464A3 PCT/TR2005/000005 TR2005000005W WO2005070464A3 WO 2005070464 A3 WO2005070464 A3 WO 2005070464A3 TR 2005000005 W TR2005000005 W TR 2005000005W WO 2005070464 A3 WO2005070464 A3 WO 2005070464A3
Authority
WO
WIPO (PCT)
Prior art keywords
tablet formulation
clopidogrel bisulphate
thieno
new
bisulphate
Prior art date
Application number
PCT/TR2005/000005
Other languages
French (fr)
Other versions
WO2005070464A2 (en
Inventor
Hatice Oencel
Ayse Guel Erkahraman
Original Assignee
Biofarma Ilac Sanayi Ve Ticare
Hatice Oencel
Ayse Guel Erkahraman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofarma Ilac Sanayi Ve Ticare, Hatice Oencel, Ayse Guel Erkahraman filed Critical Biofarma Ilac Sanayi Ve Ticare
Publication of WO2005070464A2 publication Critical patent/WO2005070464A2/en
Publication of WO2005070464A3 publication Critical patent/WO2005070464A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Abstract

This invention comprises a new formulation which solves the stability problems of a thieno pyridine derivative, anthitrombotic clopidogrel bisulphate compositions. The object of the present invention is to use a new lubricant other than magnesium stearate which cause degradation in thieno[3,2-c] pyridine derivatives. Another object of the invention is to form a new formulation and to increase stability.
PCT/TR2005/000005 2004-01-21 2005-01-17 A tablet formulation of clopidogrel bisulphate WO2005070464A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2004/00111 2004-01-21
TR200400111 2004-01-21

Publications (2)

Publication Number Publication Date
WO2005070464A2 WO2005070464A2 (en) 2005-08-04
WO2005070464A3 true WO2005070464A3 (en) 2005-11-03

Family

ID=34806336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2005/000005 WO2005070464A2 (en) 2004-01-21 2005-01-17 A tablet formulation of clopidogrel bisulphate

Country Status (2)

Country Link
TR (1) TR200505165T1 (en)
WO (1) WO2005070464A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070044323A (en) * 2005-10-24 2007-04-27 에스케이케미칼주식회사 Stabilized pharmaceutical oral preparation containing clopidogrel bisulfate
IS2385B (en) * 2006-02-10 2008-07-15 Actavis Group Hf. Clopidogrel bisulfate pharmaceutical compositions
DK1847258T4 (en) 2006-04-13 2013-04-15 Acino Pharma Ag Partial glycerides as lubricant for pharmaceutical compositions containing thieno [3,2-c] pyridine derivatives
WO2007128476A1 (en) * 2006-05-04 2007-11-15 Sandoz Ag Pharmaceutical compositions containing clopidogrel hydrochloride
CN100400035C (en) * 2006-10-18 2008-07-09 深圳信立泰药业股份有限公司 Clopidogrel sulfate solid preparation, and its preparing method
HUP0600839A3 (en) * 2006-11-14 2008-09-29 Egis Gyogyszergyar Nyrt Solid pharmaceutical composition containing polymorph i of clopidogrel hydrogensulfate and process for the preparation thereof
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
EP2095815B1 (en) 2008-02-26 2011-10-26 Laboratorios Lesvi, S.L. Pharmaceutical formulations containing clopidogrel
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
JP6004524B2 (en) * 2012-07-11 2016-10-12 大原薬品工業株式会社 Method for producing clopidogrel sulfate-containing tablets
HUP1400294A2 (en) 2014-06-13 2015-12-28 Skillpharm Kft Novel application of clopidogrel

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789875A (en) * 1993-09-20 1995-04-04 Dai Ichi Seiyaku Co Ltd Tablet free from disintegration delay
WO2000066130A1 (en) * 1999-04-30 2000-11-09 Sanofi-Synthelabo Pharmaceutical composition in unit form containing acetylsalcylic acid and clopidogrel hydrogenosulphate
WO2001012194A1 (en) * 1999-08-11 2001-02-22 Sanofi-Synthelabo Combinations with antithrombotic activity consisting of clopidogrel hydrogenosulphate and a gpiib/iiia receptor antagonist
EP1310245A1 (en) * 2001-11-09 2003-05-14 SHERMAN, Bernard Charles Clopidogrel bisulfate tablet formulation
WO2004026879A1 (en) * 2002-09-19 2004-04-01 Cipla Limited Clopidogrel
WO2004074215A1 (en) * 2003-02-03 2004-09-02 Sunil Sadanand Nadkarni Process for preparation of clopidogrel, its salts and pharmaceutical compositions
WO2005048992A1 (en) * 2003-11-03 2005-06-02 Sandoz Ag Process for preparing clopidogrel compositions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789875A (en) * 1993-09-20 1995-04-04 Dai Ichi Seiyaku Co Ltd Tablet free from disintegration delay
WO2000066130A1 (en) * 1999-04-30 2000-11-09 Sanofi-Synthelabo Pharmaceutical composition in unit form containing acetylsalcylic acid and clopidogrel hydrogenosulphate
WO2001012194A1 (en) * 1999-08-11 2001-02-22 Sanofi-Synthelabo Combinations with antithrombotic activity consisting of clopidogrel hydrogenosulphate and a gpiib/iiia receptor antagonist
EP1310245A1 (en) * 2001-11-09 2003-05-14 SHERMAN, Bernard Charles Clopidogrel bisulfate tablet formulation
WO2004026879A1 (en) * 2002-09-19 2004-04-01 Cipla Limited Clopidogrel
WO2004074215A1 (en) * 2003-02-03 2004-09-02 Sunil Sadanand Nadkarni Process for preparation of clopidogrel, its salts and pharmaceutical compositions
WO2005048992A1 (en) * 2003-11-03 2005-06-02 Sandoz Ag Process for preparing clopidogrel compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MATSUMOTO, TAKAHIRO ET AL: "Pharmaceutical tablets prevented from delayed disintegration", XP002343276, retrieved from STN Database accession no. 123:17941 *

Also Published As

Publication number Publication date
TR200505165T1 (en) 2007-01-22
WO2005070464A2 (en) 2005-08-04

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