WO2004025266A3 - Method and apparatus for sorting particles - Google Patents

Method and apparatus for sorting particles Download PDF

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Publication number
WO2004025266A3
WO2004025266A3 PCT/US2003/029198 US0329198W WO2004025266A3 WO 2004025266 A3 WO2004025266 A3 WO 2004025266A3 US 0329198 W US0329198 W US 0329198W WO 2004025266 A3 WO2004025266 A3 WO 2004025266A3
Authority
WO
WIPO (PCT)
Prior art keywords
sorting
particle
particles
pressure pulse
rate
Prior art date
Application number
PCT/US2003/029198
Other languages
French (fr)
Other versions
WO2004025266A2 (en
Inventor
John R Gilbert
Sebastian Boehm
Manish Deshpande
Original Assignee
Cytonome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/329,008 external-priority patent/US6976590B2/en
Application filed by Cytonome Inc filed Critical Cytonome Inc
Priority to AU2003270722A priority Critical patent/AU2003270722A1/en
Priority to BR0314268-0A priority patent/BR0314268A/en
Priority to EP03752432A priority patent/EP1581350A4/en
Priority to CA002499245A priority patent/CA2499245A1/en
Priority to JP2004536583A priority patent/JP2005538727A/en
Publication of WO2004025266A2 publication Critical patent/WO2004025266A2/en
Publication of WO2004025266A3 publication Critical patent/WO2004025266A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03B—SEPARATING SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS
    • B03B5/00—Washing granular, powdered or lumpy materials; Wet separating
    • B03B5/02—Washing granular, powdered or lumpy materials; Wet separating using shaken, pulsated or stirred beds as the principal means of separation
    • B03B5/10—Washing granular, powdered or lumpy materials; Wet separating using shaken, pulsated or stirred beds as the principal means of separation on jigs
    • B03B5/22—Washing granular, powdered or lumpy materials; Wet separating using shaken, pulsated or stirred beds as the principal means of separation on jigs using pulses generated by liquid injection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
    • B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
    • B07C5/34—Sorting according to other particular properties
    • G01N15/149—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1477—Multiparameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1497—Particle shape

Abstract

A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
PCT/US2003/029198 2002-09-16 2003-09-16 Method and apparatus for sorting particles WO2004025266A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003270722A AU2003270722A1 (en) 2002-09-16 2003-09-16 Method and apparatus for sorting particles
BR0314268-0A BR0314268A (en) 2002-09-16 2003-09-16 Particle Separation Method and Apparatus
EP03752432A EP1581350A4 (en) 2002-09-16 2003-09-16 Method and apparatus for sorting particles
CA002499245A CA2499245A1 (en) 2002-09-16 2003-09-16 Method and apparatus for sorting particles
JP2004536583A JP2005538727A (en) 2002-09-16 2003-09-16 Method and apparatus for classifying particles

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US41114302P 2002-09-16 2002-09-16
US41105802P 2002-09-16 2002-09-16
US60/411,058 2002-09-16
US60/411,143 2002-09-16
US10/329,008 US6976590B2 (en) 2002-06-24 2002-12-23 Method and apparatus for sorting particles
US10/329,008 2002-12-23

Publications (2)

Publication Number Publication Date
WO2004025266A2 WO2004025266A2 (en) 2004-03-25
WO2004025266A3 true WO2004025266A3 (en) 2005-08-04

Family

ID=31999089

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/029198 WO2004025266A2 (en) 2002-09-16 2003-09-16 Method and apparatus for sorting particles

Country Status (7)

Country Link
EP (1) EP1581350A4 (en)
JP (1) JP2005538727A (en)
KR (1) KR100990016B1 (en)
AU (1) AU2003270722A1 (en)
BR (1) BR0314268A (en)
CA (1) CA2499245A1 (en)
WO (1) WO2004025266A2 (en)

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JP4047336B2 (en) * 2005-02-08 2008-02-13 独立行政法人科学技術振興機構 Cell sorter chip with gel electrode
JP4509166B2 (en) * 2007-11-02 2010-07-21 ソニー株式会社 Method and apparatus for measuring fine particles
KR100940099B1 (en) * 2008-04-02 2010-02-02 한국기계연구원 Device and Method for Discriminating between Cancerous and Normal Cells
JP4661942B2 (en) 2008-05-13 2011-03-30 ソニー株式会社 Microchip and its channel structure
JP2010226978A (en) * 2009-03-26 2010-10-14 Mitsui Eng & Shipbuild Co Ltd Cell sorter
EP2462442A4 (en) 2009-08-06 2016-08-03 Univ Cornell Device and method for molecular analysis
KR101252829B1 (en) * 2009-10-06 2013-04-11 한국전자통신연구원 Array apparatus for separation of single cell
EP2641094B1 (en) * 2010-11-18 2019-03-06 The Regents of The University of California Method for high-throughput solution exchange for cell and particle suspensions
US9815060B2 (en) 2010-11-18 2017-11-14 The Regents Of The University Of California Method and device for high-throughput solution exchange for cell and particle suspensions
JP5720233B2 (en) 2010-12-17 2015-05-20 ソニー株式会社 Microchip and fine particle sorting device
EP2602608B1 (en) * 2011-12-07 2016-09-14 Imec Analysis and sorting of biological cells in flow
US9429500B2 (en) 2012-02-29 2016-08-30 Fluidigm Corporation Methods, systems and devices for multiple single-cell capturing and processing using microfluidics
CA2874343C (en) * 2012-05-21 2021-11-09 Fluidigm Corporation Single-particle analysis of particle populations
JP6172147B2 (en) 2012-07-18 2017-08-02 ソニー株式会社 Fine particle sorting device and fine particle sorting method
JP6036496B2 (en) 2012-07-24 2016-11-30 ソニー株式会社 Fine particle sorting method
JP5910412B2 (en) 2012-08-16 2016-04-27 ソニー株式会社 Microparticle sorting method and microchip for sorting microparticles
US10578633B2 (en) 2013-03-15 2020-03-03 Fluidigm Corporation Methods and devices for analysis of defined multicellular combinations
JP2016527494A (en) 2013-07-05 2016-09-08 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション Methods, compositions and systems for microfluidic assays
JP6725495B2 (en) * 2014-08-14 2020-07-22 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Apparatus and method for analyzing the output of a microfluidic device
CN107209198B (en) * 2015-04-30 2019-07-19 惠普发展公司，有限责任合伙企业 Target component positioning and discharge
US11254557B2 (en) 2016-05-17 2022-02-22 Sony Corporation Particle extraction apparatus and particle extraction method
CN108251291A (en) * 2016-12-29 2018-07-06 上海新微技术研发中心有限公司 Cell screening device and cell screening method
EP3662254A1 (en) * 2017-08-04 2020-06-10 SBT Instruments A/S Microfluidic particle analysis device
EP3672732A4 (en) * 2017-08-22 2021-05-19 Elegen Corporation Positional tracking and encoding in microfluidic devices
JP2020041881A (en) * 2018-09-10 2020-03-19 ソニー株式会社 Control device, device and system for fractionating fine particle using control device, control method, and control program
WO2021257068A1 (en) * 2020-06-17 2021-12-23 Hewlett-Packard Development Company, L.P. Determining an error in detected passage of a target particle population

Citations (3)

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US6221654B1 (en) * 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6432630B1 (en) * 1996-09-04 2002-08-13 Scandinanian Micro Biodevices A/S Micro-flow system for particle separation and analysis
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems

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JPS63259466A (en) * 1987-04-16 1988-10-26 Hitachi Ltd Cell analyzer
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Patent Citations (3)

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US6432630B1 (en) * 1996-09-04 2002-08-13 Scandinanian Micro Biodevices A/S Micro-flow system for particle separation and analysis
US6221654B1 (en) * 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems

Also Published As

Publication number Publication date
BR0314268A (en) 2005-07-26
CA2499245A1 (en) 2004-03-25
AU2003270722A1 (en) 2004-04-30
EP1581350A2 (en) 2005-10-05
JP2005538727A (en) 2005-12-22
EP1581350A4 (en) 2009-09-23
KR100990016B1 (en) 2010-10-26
WO2004025266A2 (en) 2004-03-25
KR20050047540A (en) 2005-05-20

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