WO2000024741A3 - Dihydropyridine compounds and their use as potassium channel openers - Google Patents

Dihydropyridine compounds and their use as potassium channel openers Download PDF

Info

Publication number
WO2000024741A3
WO2000024741A3 PCT/US1999/025536 US9925536W WO0024741A3 WO 2000024741 A3 WO2000024741 A3 WO 2000024741A3 US 9925536 W US9925536 W US 9925536W WO 0024741 A3 WO0024741 A3 WO 0024741A3
Authority
WO
WIPO (PCT)
Prior art keywords
potassium channel
channel openers
dihydropyridine compounds
compounds
potassium
Prior art date
Application number
PCT/US1999/025536
Other languages
French (fr)
Other versions
WO2000024741A2 (en
Inventor
William A Carroll
Konstantinos A Agrios
Fatima Z Basha
Yiyuan Chen
Michael E Kort
Philip R Kym
Rui Tang
Sean C Turner
Lin Yi
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to AU14595/00A priority Critical patent/AU1459500A/en
Priority to CA002348165A priority patent/CA2348165A1/en
Priority to EP99970991A priority patent/EP1131322A2/en
Priority to JP2000578311A priority patent/JP2002528452A/en
Publication of WO2000024741A2 publication Critical patent/WO2000024741A2/en
Publication of WO2000024741A3 publication Critical patent/WO2000024741A3/en
Priority to HK02101513.4A priority patent/HK1041878A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
PCT/US1999/025536 1998-10-28 1999-10-28 Dihydropyridine compounds and their use as potassium channel openers WO2000024741A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU14595/00A AU1459500A (en) 1998-10-28 1999-10-28 Dihydropyridine compounds and methods of use
CA002348165A CA2348165A1 (en) 1998-10-28 1999-10-28 Dihydropyridine compounds and methods of use
EP99970991A EP1131322A2 (en) 1998-10-28 1999-10-28 Dihydropyridine compounds and methods of use
JP2000578311A JP2002528452A (en) 1998-10-28 1999-10-28 Dihydropyridine compounds and methods of use
HK02101513.4A HK1041878A1 (en) 1998-10-28 2002-02-27 Dihydropyridine compounds and methods of use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18123998A 1998-10-28 1998-10-28
US09/181,239 1998-10-28
US42191299A 1999-10-20 1999-10-20
US09/421,912 1999-10-20

Publications (2)

Publication Number Publication Date
WO2000024741A2 WO2000024741A2 (en) 2000-05-04
WO2000024741A3 true WO2000024741A3 (en) 2000-07-13

Family

ID=26877009

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025536 WO2000024741A2 (en) 1998-10-28 1999-10-28 Dihydropyridine compounds and their use as potassium channel openers

Country Status (6)

Country Link
EP (1) EP1131322A2 (en)
JP (1) JP2002528452A (en)
AU (1) AU1459500A (en)
CA (1) CA2348165A1 (en)
HK (1) HK1041878A1 (en)
WO (1) WO2000024741A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191140B1 (en) * 1998-10-28 2001-02-20 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
DE60103615T2 (en) * 2000-03-03 2005-06-09 Abbott Laboratories, Abbott Park TRICYCLIC DIHYDROPYRAZOLONES AND TRICYCLIC DIHYDROISOAXAZOLONES AS KALIUM CHANNEL OPENERS
JP2004509840A (en) * 2000-05-02 2004-04-02 アボット・ラボラトリーズ Dihydropyridine compounds and methods of use
CN114516774A (en) * 2021-02-08 2022-05-20 中国科学院成都生物研究所 Preparation method of chiral bromo-1, 4-dihydropyridine compound

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0539154A1 (en) * 1991-10-21 1993-04-28 Zeneca Limited Acridine-1,8-dione-derivatives as therapeutic agents
EP0539153A1 (en) * 1991-10-21 1993-04-28 Zeneca Limited Acridine derivative as therapeutic agent
WO1994008966A1 (en) * 1992-10-20 1994-04-28 Zeneca Limited Quinolone and acridinone derivatives for the treatment of urinary incontinence
EP0705830A1 (en) * 1994-08-25 1996-04-10 Bayer Ag 2,3-Cyclic condensed 1,4-dihydropyridines, process for their preparation and their use as K-channel modulators
US5646166A (en) * 1994-12-16 1997-07-08 Bayer Aktiengesellschaft Use of 5-acyl-1,4-dihydropyridines
WO1999031059A1 (en) * 1997-12-18 1999-06-24 Abbott Laboratories Potassium channel openers

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0539154A1 (en) * 1991-10-21 1993-04-28 Zeneca Limited Acridine-1,8-dione-derivatives as therapeutic agents
EP0539153A1 (en) * 1991-10-21 1993-04-28 Zeneca Limited Acridine derivative as therapeutic agent
WO1994008966A1 (en) * 1992-10-20 1994-04-28 Zeneca Limited Quinolone and acridinone derivatives for the treatment of urinary incontinence
EP0705830A1 (en) * 1994-08-25 1996-04-10 Bayer Ag 2,3-Cyclic condensed 1,4-dihydropyridines, process for their preparation and their use as K-channel modulators
US5646166A (en) * 1994-12-16 1997-07-08 Bayer Aktiengesellschaft Use of 5-acyl-1,4-dihydropyridines
WO1999031059A1 (en) * 1997-12-18 1999-06-24 Abbott Laboratories Potassium channel openers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
C.A. FRANK ET. AL.: "Dihydropyridine KATP Potassium Channel Openers", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 3, no. 12, December 1993 (1993-12-01), pages 2725 - 6, XP000882160 *
JACK H. LI ET. AL.: "Pharmacology of ZM244085. A Novel Bladder-Selective Dihydropyridine KATP Channel Activator.", CARDIOVASCULAR DRUG REVIEWS, vol. 15, no. 3, pages 220 - 31, XP000882178 *

Also Published As

Publication number Publication date
EP1131322A2 (en) 2001-09-12
AU1459500A (en) 2000-05-15
JP2002528452A (en) 2002-09-03
WO2000024741A2 (en) 2000-05-04
CA2348165A1 (en) 2000-05-04
HK1041878A1 (en) 2002-07-26

Similar Documents

Publication Publication Date Title
HK1047088A1 (en) Potassium channel openers
WO2001009096A3 (en) Potassium channel openers
AU2002343561A1 (en) Composition and method for growing, protecting, and healing tissues and cells
AU1837800A (en) Compositions and methods for whitening teeth
AU6579494A (en) 1,4-benzoxazine derivatives as potassium channel openers
BG104999A (en) Cyclopentanone dihydropyridine compositions useful as potassium channel openers
AU1747400A (en) Multiple-thickness gate oxide formed by oxygen implantation
WO2002062762A3 (en) Potassium channel openers
MXPA03007071A (en) Aminal diones as potassium channel openers.
IL135985A0 (en) Potassium channel openers
WO2000024741A3 (en) Dihydropyridine compounds and their use as potassium channel openers
WO2001066544A3 (en) Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
AU1612100A (en) Compositions and methods for whitening teeth
WO1999051779A3 (en) Glaucoma therapeutics and diagnostics
AU4859399A (en) Compositions and methods for treating papillomavirus-infected cells
WO2001083480A3 (en) Dihydropyridine compounds and methods of use
AU2001238288A1 (en) Method and compositions for treating fibrotic diseases
AU2002305700A1 (en) Composition and method for treating cells
AU2002324441A1 (en) Composition and method for treating cells and plants
GB9407432D0 (en) Heterocyclic derivative
AU7743500A (en) Methods and compositions relating to novel sodium channel $(b)1a subunits
AU2002361711A1 (en) METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL DISORDERS USING 252, 304, 19870, 14717, 9941, 19310 and 17832
AU2001296075A1 (en) Composition for treating acne vulgaris and fabrication method

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref country code: AU

Ref document number: 2000 14595

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2348165

Country of ref document: CA

Ref country code: CA

Ref document number: 2348165

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 578311

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/004246

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 1999970991

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1999970991

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1999970991

Country of ref document: EP