WO1995006726A3 - Dna molecule encoding for cellular uptake of mycobacterium tuberculosis - Google Patents
Dna molecule encoding for cellular uptake of mycobacterium tuberculosis Download PDFInfo
- Publication number
- WO1995006726A3 WO1995006726A3 PCT/US1994/009863 US9409863W WO9506726A3 WO 1995006726 A3 WO1995006726 A3 WO 1995006726A3 US 9409863 W US9409863 W US 9409863W WO 9506726 A3 WO9506726 A3 WO 9506726A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mycobacterium tuberculosis
- dna molecule
- protein
- molecule encoding
- cellular uptake
- Prior art date
Links
- 241000187479 Mycobacterium tuberculosis Species 0.000 title abstract 4
- 108020004414 DNA Proteins 0.000 title abstract 2
- 102000053602 DNA Human genes 0.000 title abstract 2
- 230000004700 cellular uptake Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention relates to a DNA molecule conferring on Mycobacterium tuberculosis an ability to enter mammalian cells and to survive within macrophages. The protein encoded by this gene fragment is useful in vaccines to prevent infection by Mycobacterium tuberculosis, while the antibodies raised against this protein can be employed in passively immunizing those already infected by the organism. Both these proteins and antibodies may be utilized in diagnostic assays to detect Mycobacterium tuberculosis in tissue or bodily fluids. The protein of the present invention can be associated with various other therapeutic materials, for administration to mammals, particularly humans, to achieve uptake of those materials by such cells.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7508259A JPH09502095A (en) | 1993-09-02 | 1994-09-01 | DNA molecule encoding the cellular uptake of Mycobacterium tuberculosis |
| CA002170148A CA2170148A1 (en) | 1993-09-02 | 1994-09-01 | Dna molecule encoding for cellular uptake of mycobacterium tuberculosis |
| BR9407527A BR9407527A (en) | 1993-09-02 | 1994-09-01 | Isolated dna molecule isolated protein or polypeptide recombinant dna expression system host cell vaccine to prevent infection and disease in mammals isolated antibody or binding portion of it and product for uptake of materials into mammalian cells and mammalian vaccination processes against passive immunization infection of infected mammals for detection of mycobacterium tuberculosis in a sample and cell uptake |
| EP94926657A EP0724635A1 (en) | 1993-09-02 | 1994-09-01 | Dna molecule encoding for cellular uptake of mycobacterium tuberculosis |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11844293A | 1993-09-02 | 1993-09-02 | |
| US08/118,442 | 1993-09-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1995006726A2 WO1995006726A2 (en) | 1995-03-09 |
| WO1995006726A3 true WO1995006726A3 (en) | 1995-04-27 |
Family
ID=22378619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1994/009863 WO1995006726A2 (en) | 1993-09-02 | 1994-09-01 | Dna molecule encoding for cellular uptake of mycobacterium tuberculosis |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0724635A1 (en) |
| JP (1) | JPH09502095A (en) |
| CN (1) | CN1133063A (en) |
| BR (1) | BR9407527A (en) |
| CA (1) | CA2170148A1 (en) |
| WO (1) | WO1995006726A2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6509151B1 (en) * | 1993-09-02 | 2003-01-21 | Cornell Research Foundation, Inc. | DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof |
| US6008201A (en) * | 1993-09-02 | 1999-12-28 | Cornell Research Foundation, Inc. | DNA molecule encoding for cellular uptake of mycobacterium tuberculosis and uses thereof |
| JP2000509981A (en) * | 1996-04-29 | 2000-08-08 | ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ） | DNA, RNA and proteins useful for detecting Mycobacterium infection |
| US6444444B1 (en) * | 1996-07-10 | 2002-09-03 | Aventis Pasteur Limited | Genes encoding mycobacterial proteins associated with cell binding and cell entry and uses thereof |
| US6224881B1 (en) | 1996-08-07 | 2001-05-01 | Cornell Research Foundation, Inc. | DNA molecule fragments encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof |
| US6072048A (en) * | 1997-03-10 | 2000-06-06 | Cornell Research Foundation, Inc. | DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof |
| US6177086B1 (en) | 1997-05-06 | 2001-01-23 | Cornell Research Foundation, Inc. | DNA molecule conferring on Mycobacterium tuberculosis resistance against antimicrobial reactive oxygen and nitrogen intermediates |
| FR2767337B1 (en) * | 1997-08-14 | 2002-07-05 | Pasteur Institut | NUCLEIC SEQUENCES OF POLYPEPTIDES EXPORTED FROM MYCOBACTERI ES, VECTORS COMPRISING THEM AND APPLICATIONS TO DIAGNOSIS AND THE PREVENTION OF TUBERCULOSIS |
| US6136324A (en) | 1997-08-21 | 2000-10-24 | Connaught Laboratories Limited | Attenuated strains of mycobacteria |
| CN112899329B (en) * | 2021-02-02 | 2022-05-10 | 成都可恩生物科技有限公司 | Method for producing tuberculin pure protein derivative |
-
1994
- 1994-09-01 JP JP7508259A patent/JPH09502095A/en active Pending
- 1994-09-01 WO PCT/US1994/009863 patent/WO1995006726A2/en not_active Application Discontinuation
- 1994-09-01 CA CA002170148A patent/CA2170148A1/en not_active Abandoned
- 1994-09-01 BR BR9407527A patent/BR9407527A/en not_active Application Discontinuation
- 1994-09-01 CN CN94193768.2A patent/CN1133063A/en active Pending
- 1994-09-01 EP EP94926657A patent/EP0724635A1/en not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| ARRUDA S;BOMFIM G;JOHNSON W D JR;RILEY L W;: "CLONING OF A MYCOBACTERIUM-TUBERCULOSIS GENE NECESSARY FOR INVASION OF CULTURED EPITHELIAL CELLS", ABSTR GEN MEET AM SOC MICROBIOL, vol. 92, 1992, pages 41 * |
| ARRUDA S;BOMFIN G;KNIGHTS R;HUIMA-BYRON T;RILEY L W ;: "Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells", SCIENCE, vol. 261, 10 September 1993 (1993-09-10), LANCASTER, PA, pages 1454 - 1457 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995006726A2 (en) | 1995-03-09 |
| BR9407527A (en) | 1997-11-11 |
| EP0724635A1 (en) | 1996-08-07 |
| JPH09502095A (en) | 1997-03-04 |
| CA2170148A1 (en) | 1995-03-09 |
| CN1133063A (en) | 1996-10-09 |
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