US2783908A - Closures for bottles, vials and the like - Google Patents

Closures for bottles, vials and the like Download PDF

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US2783908A
US2783908A US409173A US40917354A US2783908A US 2783908 A US2783908 A US 2783908A US 409173 A US409173 A US 409173A US 40917354 A US40917354 A US 40917354A US 2783908 A US2783908 A US 2783908A
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Prior art keywords
stopper
neck
container
vials
closures
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Expired - Lifetime
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US409173A
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Winfield John Leslie
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Glaxo Laboratories Ltd
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Glaxo Laboratories Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D39/00—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/03—Medical

Definitions

  • This invention is concerned with improvements in or relating to closures for bottles, jars, vials and like containers, and more particularly, although not exclusively to such containers as are intended to carry substances where it is of great importance that moisture should be as far as possible completely excluded from the contents of the container.
  • antibiotic preparations such as penicillin and its salts since activity will be lost as a result of such contact.
  • Many of these antibiotic preparations are administered by injection and it is usual for them to be packed in vials or other containers under sterile conditions, which containers have closures or stoppers through which the needle of a syringe can 'be inserted to withdraw a dose without removing the closure.
  • vials or containers of rubber in the form of conventional stoppers having a shoulder which abuts against the upper surface of the neck of the container.
  • a glass bottle, jar, vial or like container which is substantially completely moisture-proof and which comprises a shoulder or seating within the neck of the container, and a stopper member disposed on said seating and of such dimensions that it is flush with or lower than the top edge of said neck characterised by the provision of a disc or the like of metallic foil adhesively secured to the upper surface of said neck.
  • the said metallic foil is preferably aluminium foil and we prefer to use an aluminium foil backed with a heat sealing adhesive composition which is known per se.
  • the stopper does not extend above the top of the container neck, but is at most flush therewith this manufacturing difiiculty is overcome and the foil may be simply stamped out .in fiat discs of a diameter equal to the outer diameter of the container neck to which they are applied in the presence of heat.
  • foil discs with a tongue or flap adapted to lie down the side of the neck and which serves as a tear oif strip.
  • foils or other metals than aluminium such as tinor lead and a separate application of a suitable adhesive may also be used.
  • the shoulder or seating in the neck of the container preferably forms substantially a right angle with the bore of the neck and preferably extends right around the inf'the neck, it will be apparent however that the shape, size and extent of the shoulder or seatingmay be varied provided that it serves to retain the stopper and prevent the latter from being pushed into the container, and that it is of sufiicient depth in relation to the dimensions of the stopper to prevent the latter from being pulled out when a hypodermic needle is withdrawn ,cross' sections of stopper may be employed according to this invention.
  • the latter may be of reduced thickness over the whole or part of the central area thereof and may have a concavity or recessed portron. in the outer surface, and may also have a corresponding recessed portion on the underside as'well.
  • the stopper may have an annular rim or edge of greater thickness than that of the central portion thereof.
  • WeZinay also provide the stopper in the form of a disc of uniform thickness, or again the underside of the stopper may have a plug-like extension adapted to extend downwardly into the neck. It will however be understood that in all cases the dimensions of the stopper will be so selected that it will not protrude above the top edge of the neck of the container. We may in some cases radius off the upper edge of the stopper to allow for slightly oversize stoppers and to facilitate proper adhesion between the foil disc and the edge of the container.
  • a target area on the centre part of the stopper may indicate where a needle should be inserted.
  • the stopper we prefer to shape the stopper so that its outer afisspos surface at the centre is spaced inwardly from the plane of the upper edge of the neck of the container so that whilst the foil disc will adhere to the top of the container and in some cases the peripheral portion of the stopper, it will not adhere to the central area.
  • Figure 1 is a section through a vial suitable for an antibiotic preparation.
  • Figures 2 to 8 each show a section through the neck of the vial of Figure 1 with a different form of stopper therein.
  • Figure 9 shows a sectional side view of a vial completely closed in accordance with this invention.
  • Figure 9 shows a plan view of Figure 9 and Figure 11 shows a preferred form of foil disc.
  • Figure 1 shows a glass vial 1 having a neck 2 with a square shoulder 3 extending around the inside.
  • the neck 2 of the vial has a fiat upper surface 4.
  • Such vials may conveniently be used for penicillin and other antibiotics and for quantities of say from 5-30 cc. it is only necessary to increase the height of the vial without necessarily varying the dimensions of the neck.
  • a depth of shoulder from the edge 4 of A" and a radial width of shoulder of ;8" gives satisfactory results although it will be understood that we do not in any way limit the invention to such dimensions.
  • Figure 2 shows a rubber stopper inserted into the neck .of the vial 1.
  • the stopper has a rim 5 adapted to seat on the shoulder 3 and of such thickness that it is just flush with surface 4 when so seated.
  • the edge is radiused as at 6 to facilitate the application to the closure-of a foil disc 7 for instance as shown in Figure 11.
  • the central portion 8 of the stopper is of less thickness than the rim 5 to facihtate entry of a hypodermic needle.
  • Figure 3 shows a modified stopper having recessed portions 9 in the central area on the upper and lower side.
  • Figure 4 shows a flat disc of thickness less than the depth of shoulder 3.
  • Figure 5 shows another form of stopper having a rim ,10, radiused at 11 and 12 and having a flat recessed central portion 13 on the upper side only.
  • Figure 6 shows a stopper similar to that of Figure 3 only having small concave recesses 14 on each surface.
  • the stopper in Figure 7 has a concave recess 15 in the upper surface only.
  • FIG 8 a preferred form of stopper is shown having a plug portion 16 extending into the neck of the vial.
  • This stopper has a concave central portion 17 onthe upper surface and is hollowed out at 18 on the underside to enable a hypodermic needie to be easily inserted.
  • Figure 11 shows a disc of aluminium foil 7 having a heat sealing adhesive on its underside which, according to this invention is secured directly to the upper surface 4 of the vials shown in any of Figures 1 to 9.
  • the said disc 7 has a tab 20 to serve as a tear off tab for the closure.
  • a heat sealing adhesive based on polyisobutylene and rosin and preferably we employ an adhesive sold under the trademark Telstic.”
  • Figure 9 shows the vial 1 completely closed.
  • a stopper 21 is seated on shoulder 3 and is so dimensioned that it does not extend beyond surface 4.
  • a centre point 22 (see Figure 10) and a target ring 23 are moulded or otherwise marked on the upper surface, to indicate where a needle should be inserted.
  • a disc ( Figure 11) is applied to the upper surface 4 of the vial and when heated adheres thereto and to the portions of the stopper flush therewith but not to the central portion 24.
  • the vial is then completely sealed against moisture.
  • the neck of the vial is preferably of a diameter not greater than that of the base to facilitate packing a number of such vials.
  • closure means have been provided which, whilst giving a better and more moisture tight seal than those hitherto proposed, are simpler in construction and are less expensive since the fact that the porosity of the stopper is no longer of critical importance, enables a wider range of cheaper compositions to be used, and makes it unnecessary to use the somewhat costly rubber mixes hitherto used. Furthermore variation in batches of rubber becomes relatively unimportant.
  • thermoplastic adhesive comprises polyisobutylene and rosin.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Description

I J. L. WINFlELD CLOSURES FOR BOTTLES, VIALS AND THE LIKE March 5, 1957 Filed Feb. 9, 1954 2 Sheets-Sheet l Ton/Y L E $1.15 WIN Fl EL L A ttorney March 5, 1957 J. L. WINFIELD CLOSURES FOR BOTTLES, VIALS AND THE LIKE 2 Sheets-Sheet 2" Filed Feb. 9, 1954 U G F Inve zn Lesus w for l'NFIEL. D
ilo vw Attorneys United 2,783,908 CLOSURES FOR BOTTLES, VIALS AND THE LIKE Application February 9, 1954, Serial No. 409,173?
Claims priority, application Great Britain February 13, 1953 2 Claims. (Cl. 215-37) This invention is concerned with improvements in or relating to closures for bottles, jars, vials and like containers, and more particularly, although not exclusively to such containers as are intended to carry substances where it is of great importance that moisture should be as far as possible completely excluded from the contents of the container.
It is, for instance, extremely important that moisture should be excluded from contact with antibiotic preparations such as penicillin and its salts since activity will be lost as a result of such contact. Many of these antibiotic preparations are administered by injection and it is usual for them to be packed in vials or other containers under sterile conditions, which containers have closures or stoppers through which the needle of a syringe can 'be inserted to withdraw a dose without removing the closure. for such vials or containers of rubber in the form of conventional stoppers having a shoulder which abuts against the upper surface of the neck of the container. In order to reduce the possibility of moisture entering the container it has hitherto been the practice to provide an annulus of channel section, of aluminium for instance which surrounds the junction of the stopper and the neck of the container, the sides of the channel engaging over the upper edge of the stopper and a shoulder on the neck of the container respectively. In the manufacture of such closures it has been necessary to useonly specially selected rubber mixtures which have the minimum porosity and which at the same time, will not flake or fragment when pierced by a hypodermic needle, and which will not form a core or plug in the bore of the needle. Such special rubber mixtures are costly and closures of the above mentioned variety are not entirely satisfactory in excluding moisture from the contents of the container, since penetration does take place either through the rubber itself or between the said annulus and the vial or stopper and thence between the neck of the container and the shoulder of the stopper.
"It is an object of the present invention to provide an improved closure for glass bottles, jars, vials and like containers which compares favourably in price withthose hitherto known for comparable purposes and'whic'h at the same time substantially completely excludes moisture from the contents.
According to the present invention therefore, we provide a glass bottle, jar, vial or like container, which is substantially completely moisture-proof and which comprises a shoulder or seating within the neck of the container, and a stopper member disposed on said seating and of such dimensions that it is flush with or lower than the top edge of said neck characterised by the provision of a disc or the like of metallic foil adhesively secured to the upper surface of said neck.
The said metallic foil is preferably aluminium foil and we prefer to use an aluminium foil backed with a heat sealing adhesive composition which is known per se.
We have found that a very suitable adhesive for this rates Patent It is known to provide closures side '0 2,783,908 Patented Mar. 5, 19 57 purpose is a thermoplastic adhesive based upon polyisobutylene and rosin, and we prefer to use such an adhesive known under the trademark Telstic. We have found that this adhesive which has been known for other sealing purposes, and which has. the advantage of being completely impervious to moisture, is also capable of making a moisture tight seal directly on glass. It has not however hitherto been convenient to use it for the purpose now proposed owing to the difficulties of. mass producing a cap portion having a disc and skirt, as would be' necessary for known stoppers and containers, without such cap adhering to one of the die parts, by which it is formed due to the heat of stamping, making the adhesive tacky.
Since, according to this invention the stopper does not extend above the top of the container neck, but is at most flush therewith this manufacturing difiiculty is overcome and the foil may be simply stamped out .in fiat discs of a diameter equal to the outer diameter of the container neck to which they are applied in the presence of heat. We prefer to provide such foil discs with a tongue or flap adapted to lie down the side of the neck and which serves as a tear oif strip. If desired we may use foils or other metals than aluminium such as tinor lead and a separate application of a suitable adhesive may also be used.
Owing to the metallic foil used to provide the eflective seal against moisture it will be appreciated that a wider choice of materials is available for the stopper as critical considerations of porosity no longer arise. We prefer to use rubber or a rubber composition for the stopper and in selecting the material for the stopper it is important only that the material should be inert to the intended contents of the container and should not flake or fragment or form a core when pierced e. g. by a hypodermic needle.
The shoulder or seating in the neck of the container preferably forms substantially a right angle with the bore of the neck and preferably extends right around the inf'the neck, it will be apparent however that the shape, size and extent of the shoulder or seatingmay be varied provided that it serves to retain the stopper and prevent the latter from being pushed into the container, and that it is of sufiicient depth in relation to the dimensions of the stopper to prevent the latter from being pulled out when a hypodermic needle is withdrawn ,cross' sections of stopper may be employed according to this invention.
Thus to facilitate entry of a hypodermic needle through the stopper the latter may be of reduced thickness over the whole or part of the central area thereof and may have a concavity or recessed portron. in the outer surface, and may also have a corresponding recessed portion on the underside as'well. If
desired the stopper may have an annular rim or edge of greater thickness than that of the central portion thereof. WeZinay also provide the stopper in the form of a disc of uniform thickness, or again the underside of the stopper may have a plug-like extension adapted to extend downwardly into the neck. It will however be understood that in all cases the dimensions of the stopper will be so selected that it will not protrude above the top edge of the neck of the container. We may in some cases radius off the upper edge of the stopper to allow for slightly oversize stoppers and to facilitate proper adhesion between the foil disc and the edge of the container.
If desired we may mark a target area on the centre part of the stopper to indicate where a needle should be inserted. We prefer to shape the stopper so that its outer afisspos surface at the centre is spaced inwardly from the plane of the upper edge of the neck of the container so that whilst the foil disc will adhere to the top of the container and in some cases the peripheral portion of the stopper, it will not adhere to the central area.
In order that the invention may be well understood some preferred embodiments thereof by way of example only will now be described with reference to the accompanying drawing in which:
Figure 1 is a section through a vial suitable for an antibiotic preparation.
Figures 2 to 8 each show a section through the neck of the vial of Figure 1 with a different form of stopper therein.
Figure 9 shows a sectional side view of a vial completely closed in accordance with this invention.
' Figure shows a plan view of Figure 9 and Figure 11 shows a preferred form of foil disc.
Figure 1 shows a glass vial 1 having a neck 2 with a square shoulder 3 extending around the inside. The neck 2 of the vial has a fiat upper surface 4. Such vials may conveniently be used for penicillin and other antibiotics and for quantities of say from 5-30 cc. it is only necessary to increase the height of the vial without necessarily varying the dimensions of the neck. We have found that for such vials a depth of shoulder from the edge 4 of A" and a radial width of shoulder of ;8" gives satisfactory results although it will be understood that we do not in any way limit the invention to such dimensions.
Figure 2 shows a rubber stopper inserted into the neck .of the vial 1. The stopper has a rim 5 adapted to seat on the shoulder 3 and of such thickness that it is just flush with surface 4 when so seated. The edge is radiused as at 6 to facilitate the application to the closure-of a foil disc 7 for instance as shown in Figure 11. The central portion 8 of the stopper is of less thickness than the rim 5 to facihtate entry of a hypodermic needle.
Figure 3 shows a modified stopper having recessed portions 9 in the central area on the upper and lower side.
Figure 4 shows a flat disc of thickness less than the depth of shoulder 3. V
Figure 5 shows another form of stopper having a rim ,10, radiused at 11 and 12 and having a flat recessed central portion 13 on the upper side only.
Figure 6 shows a stopper similar to that of Figure 3 only having small concave recesses 14 on each surface.
The stopper in Figure 7 has a concave recess 15 in the upper surface only.
In Figure 8 a preferred form of stopper is shown having a plug portion 16 extending into the neck of the vial. This stopper has a concave central portion 17 onthe upper surface and is hollowed out at 18 on the underside to enable a hypodermic needie to be easily inserted.
Figure 11 shows a disc of aluminium foil 7 having a heat sealing adhesive on its underside which, according to this invention is secured directly to the upper surface 4 of the vials shown in any of Figures 1 to 9. The said disc 7 has a tab 20 to serve as a tear off tab for the closure. We prefer to use a heat sealing adhesive based on polyisobutylene and rosin and preferably we employ an adhesive sold under the trademark Telstic."
Figure 9 shows the vial 1 completely closed. A stopper 21 is seated on shoulder 3 and is so dimensioned that it does not extend beyond surface 4. A centre point 22 (see Figure 10) and a target ring 23 are moulded or otherwise marked on the upper surface, to indicate where a needle should be inserted. A disc (Figure 11) is applied to the upper surface 4 of the vial and when heated adheres thereto and to the portions of the stopper flush therewith but not to the central portion 24.
The vial is then completely sealed against moisture. As will be seen from Figures 1 and 9 the neck of the vial is preferably of a diameter not greater than that of the base to facilitate packing a number of such vials.
It will be seen that closure means have been provided which, whilst giving a better and more moisture tight seal than those hitherto proposed, are simpler in construction and are less expensive since the fact that the porosity of the stopper is no longer of critical importance, enables a wider range of cheaper compositions to be used, and makes it unnecessary to use the somewhat costly rubber mixes hitherto used. Furthermore variation in batches of rubber becomes relatively unimportant.
It will be understood that we have only described certain preferred embodiments of our invention by way of example and that variations and modifications may be made therein without departing from the scope of the .invention. Thus whilst we have described in particular small vials for antibiotics it will be understood that the invention can be applied to larger containers for any sub stances or contents where the complete exclusion of moisture is of importance.
,wardly beyond said end surface, a separate flat sealing disc of imperforate metal foil extending across said open end and said end surface, and a moisture impervious thermoplas'tic adhesive securing said fiat foil disc to said flat end surface, the peripheral edge of at least the major portion of said disc being sealed to said flat end surface.
.2. A sealed container as defined in claim 1 in which said thermoplastic adhesive comprises polyisobutylene and rosin.
References Cited in the file of this patent UNITED STATES PATENTS 711,146 Yerby Oct. 14, 1902 1,630,867 Smith May 31, 1927 1,683,313 Stewart Sept. 4, 1928 1,814,650 Waite July 14, 1931 2,305,744 Sonnenberg Dec. 22, 1942 I 2,373,847 Osborne Apr. 17, 1945 FOREIGN PATENTS 411,081 Germany Mar. 14, 1925 325,629 Great Britain Feb. 27, 1930 368,818 Great Britain Mar. 9, 1932 w; an
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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3424218A (en) * 1966-12-07 1969-01-28 Garrett Corp Medical material container
US3655084A (en) * 1970-01-30 1972-04-11 Bosch Gmbh Robert Container with pressure retaining sealing elements
US3759374A (en) * 1969-07-03 1973-09-18 Merck Patent Gmbh Cuvette
US3870183A (en) * 1973-04-09 1975-03-11 Viceroy Mfg Co Closure for liquid containers
EP0189391A2 (en) * 1985-01-24 1986-07-30 C.A. Greiner & Söhne Gesellschaft M.B.H. Blood sample tube
US4863453A (en) * 1987-12-22 1989-09-05 Sherwood Medical Company Sterile closure device
US4984415A (en) * 1987-04-07 1991-01-15 Fuso Pharmaceutical Industries, Ltd. Method and apparatus for blockading an opening through a cylindrical mouthpiece of a synthetic resin container
US5611792A (en) * 1992-04-12 1997-03-18 Dicamed Ab Value device for aseptic injection and removal of a medical fluid into/from a container
US5947274A (en) * 1994-08-05 1999-09-07 Smithkline Beecham P.L.C. Desiccating container for moisture-sensitive material
US6299131B1 (en) * 1998-10-05 2001-10-09 Rymed Technologies, Inc. Swabbable needleless injection port system having low reflux
US20030083606A1 (en) * 1998-06-03 2003-05-01 Epstein Gordon Howard Direct dual filling device for sealing agents
US20060091098A1 (en) * 2002-08-16 2006-05-04 Jacques Thilly Closure system for a vial, vial, method of closing and filling a vial and stand for a vial
US20070102393A1 (en) * 2005-09-20 2007-05-10 Biomerieux Specimen enclosure apparatus and containers and closure devices for the same
US20090134114A1 (en) * 2005-05-17 2009-05-28 Glaxosmithkline Biologicals, S.A. Closure system and method of filling a vial
US20090158612A1 (en) * 2004-10-27 2009-06-25 Jacques Thilly Process for preparing a lyophilised material
US20090306620A1 (en) * 2006-03-07 2009-12-10 Jacques Thilly Medicinal vial
US7832078B2 (en) 2003-07-08 2010-11-16 Aseptic Technologies S.A. Process and apparatus for producing a vial in a sterile environment
US20100327010A1 (en) * 2009-06-30 2010-12-30 Manera David A Press in bottle adapter
US20130102989A1 (en) * 2011-10-25 2013-04-25 Target Brands, Inc. Dispensing insert for a medicine containment and dispensing system and associated method
EP2817237A2 (en) * 2012-02-24 2014-12-31 Krones AG Pierceable plastic closure for closing containers
US20170190484A1 (en) * 2007-08-31 2017-07-06 Saint-Gobain Performance Plastics Corporation Septa
US9763854B2 (en) 2015-05-20 2017-09-19 L. Perrigo Company Flow restrictor
USD840239S1 (en) 2011-10-25 2019-02-12 Cvs Pharmacy, Inc. Bottle
US11903902B2 (en) 2022-01-03 2024-02-20 Benjamin Martin DAVIS Fluid transfer couplings

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US711146A (en) * 1901-12-30 1902-10-14 Ross B Yerby Closure device for bottles or similar vessels.
DE411081C (en) * 1924-03-01 1925-03-14 Albert Russ Rubber plates to close evacuated preservation vessels
US1630867A (en) * 1925-12-28 1927-05-31 Edward D Smith Milk-bottle cover and receptacle
US1683313A (en) * 1926-12-14 1928-09-04 Stewart Mfg Company Bottle cap
GB325629A (en) * 1928-12-13 1930-02-27 Arthur Clarence Forster Improvements in and connected with closures or seals for jars, bottles, and similar containers, and in jars, bottles, and similar containers
US1814650A (en) * 1928-11-16 1931-07-14 Antidolor Mfg Co Inc Medicament container
GB368818A (en) * 1930-12-09 1932-03-09 Kathleen Joy Earle Improvements in and relating to closures for bottles, pots, and the like
US2305744A (en) * 1938-06-24 1942-12-22 Mid West Bottle Cap Co Bottle cap
US2373847A (en) * 1940-08-03 1945-04-17 Aluminum Co Of America Coated foil closure

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US711146A (en) * 1901-12-30 1902-10-14 Ross B Yerby Closure device for bottles or similar vessels.
DE411081C (en) * 1924-03-01 1925-03-14 Albert Russ Rubber plates to close evacuated preservation vessels
US1630867A (en) * 1925-12-28 1927-05-31 Edward D Smith Milk-bottle cover and receptacle
US1683313A (en) * 1926-12-14 1928-09-04 Stewart Mfg Company Bottle cap
US1814650A (en) * 1928-11-16 1931-07-14 Antidolor Mfg Co Inc Medicament container
GB325629A (en) * 1928-12-13 1930-02-27 Arthur Clarence Forster Improvements in and connected with closures or seals for jars, bottles, and similar containers, and in jars, bottles, and similar containers
GB368818A (en) * 1930-12-09 1932-03-09 Kathleen Joy Earle Improvements in and relating to closures for bottles, pots, and the like
US2305744A (en) * 1938-06-24 1942-12-22 Mid West Bottle Cap Co Bottle cap
US2373847A (en) * 1940-08-03 1945-04-17 Aluminum Co Of America Coated foil closure

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3424218A (en) * 1966-12-07 1969-01-28 Garrett Corp Medical material container
US3759374A (en) * 1969-07-03 1973-09-18 Merck Patent Gmbh Cuvette
US3655084A (en) * 1970-01-30 1972-04-11 Bosch Gmbh Robert Container with pressure retaining sealing elements
US3870183A (en) * 1973-04-09 1975-03-11 Viceroy Mfg Co Closure for liquid containers
EP0189391A2 (en) * 1985-01-24 1986-07-30 C.A. Greiner & Söhne Gesellschaft M.B.H. Blood sample tube
US4664274A (en) * 1985-01-24 1987-05-12 C. A. Greiner & Sohne Gesellschaft Mbh Blood-sampling tube
EP0189391A3 (en) * 1985-01-24 1989-05-10 C.A. Greiner & Söhne Gesellschaft M.B.H. Blood sample tube
US4984415A (en) * 1987-04-07 1991-01-15 Fuso Pharmaceutical Industries, Ltd. Method and apparatus for blockading an opening through a cylindrical mouthpiece of a synthetic resin container
US4863453A (en) * 1987-12-22 1989-09-05 Sherwood Medical Company Sterile closure device
US5611792A (en) * 1992-04-12 1997-03-18 Dicamed Ab Value device for aseptic injection and removal of a medical fluid into/from a container
US5947274A (en) * 1994-08-05 1999-09-07 Smithkline Beecham P.L.C. Desiccating container for moisture-sensitive material
US20030010668A1 (en) * 1994-08-05 2003-01-16 West Pharmaceutical Services, Inc. Desiccating container for moisture-sensitive material
US20030083606A1 (en) * 1998-06-03 2003-05-01 Epstein Gordon Howard Direct dual filling device for sealing agents
US7081103B2 (en) * 1998-06-03 2006-07-25 Baxter International Inc. Direct dual filling device for sealing agents
US6299131B1 (en) * 1998-10-05 2001-10-09 Rymed Technologies, Inc. Swabbable needleless injection port system having low reflux
US20060091098A1 (en) * 2002-08-16 2006-05-04 Jacques Thilly Closure system for a vial, vial, method of closing and filling a vial and stand for a vial
US7946437B2 (en) * 2002-08-16 2011-05-24 Aseptic Technologies S.A. Closure system for a vial, vial, method of closing and filling a vial and stand for a vial
US7832078B2 (en) 2003-07-08 2010-11-16 Aseptic Technologies S.A. Process and apparatus for producing a vial in a sterile environment
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