US20030134407A1

US20030134407A1 - Nucleic acids and proteins from Streptococcus pneumoniae

Info

Publication number: US20030134407A1
Application number: US09/769,744
Authority: US
Inventors: Richard William Le Page; Jeremy Wells; Sean Hanniffy; Philip Hansbro
Original assignee: Microbial Technics Ltd
Current assignee: Microbial Technics Ltd
Priority date: 1998-07-27
Filing date: 2001-01-26
Publication date: 2003-07-17
Also published as: US20060263378A1; US8632784B2

Abstract

Novel proteins from Streptococcus pneumoniae are described, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.

Description

The present invention relates to proteins derived from Streptococcus pneumoniae, nucleic acid molecules encoding such proteins, the use of the nucleic acid and/or proteins as antigens/immunogens and in detection/diagnosis, as well as methods for screening the proteins/nucleic acid sequences as potential anti-microbial targets.

Streptococcus pneumoniae, commonly referred to as the pneumococcus, is an important pathogenic organism. The continuing significance of Streptoccocus pneumoniae infections in relation to human disease in developing and developed countries has been authoritatively reviewed (Fiber, G. R., Science, 265: 1385-1387 (1994)). That indicates that on a global scale this organism is believed to be the most common bacterial cause of acute respiratory infections, and is estimated to result in 1 million childhood deaths each year, mostly in developing countries (Stansfield, S. K., Pediatr. Infect. Dis., 6: 622 (1987)). In the USA it has been suggested (Breiman et al, Arch. Intern. Med., 150: 1401 (1990)) that the pneumococcus is still the most common cause of bacterial pneumonia, and that disease rates are particularly high in young children, in the elderly, and in patients with predisposing conditions such as asplenia, heart, lung and kidney disease, diabetes, alcoholism, or with immunosupressive disorders, especially AIDS. These groups are at higher risk of pneumococcal septicaemia and hence meningitis and therefore have a greater risk of dying from pneumococcal infection. The pneumococcus is also the leading cause of otitis media and sinusitis, which remain prevalent infections in children in developed countries, and which incur substantial costs.

The need for effective preventative strategies against pneumococcal infection is highlighted by the recent emergence of penicillin-resistant pneumococci. It has been reported that 6.6% of pneumoccal isolates in 13 US hospitals in 12 states were found to be resistant to penicillin and some isolates were also resistant to other antibiotics including third generation cyclosporins (Schappert, S. M., Vital and Health Statistics of the Centres for Disease Control/National Centre for Health Statistics, 214:1 (1992)). The rates of penicillin resistance can be higher (up to 20%) in some hospitals (Breiman et al, J. Am. Med. Assoc., 271: 1831 (1994)). Since the development of penicillin resistance among pneumococci is both recent and sudden, coming after decades during which penicillin remained an effective treatment, these findings are regarded as alarming.

For the reasons given above, there are therefore compelling grounds for considering improvements in the means of preventing, controlling, diagnosing or treating pneumococcal diseases.

Various approaches have been taken in order to provide vaccines for the prevention of pneumococcal infections. Difficulties arise for instance in view of the variety of serotypes (at least 90) based on the structure of the polysaccharide capsule surrounding the organism. Vaccines against individual serotypes are not effective against other serotypes and this means that vaccines must include polysaccharide antigens from a whole range of serotypes in order to be effective in a majority of cases. An additional problem arises because it has been found that the capsular polysaccharides (each of which determines the serotype and is the major protective antigen) when purified and used as a vaccine do not reliably induce protective antibody responses in children under two years of age, the age group which suffers the highest incidence of invasive pneumococcal infection and meningitis.

A modification of the approach using capsule antigens relies on conjugating the polysaccharide to a protein in order to derive an enhanced immune response, particularly by giving the response T-cell dependent character. This approach has been used in the development of a vaccine against Haemophilus influenzae, for instance. There are, however, issues of cost concerning both the multi-polysaccharide vaccines and those based on conjugates.

A third approach is to look for other antigenic components which offer the potential to be vaccine candidates. This is the basis of the present invention. Using a specially developed bacterial expression system, we have been able to identify a group of protein antigens from pneomococcus which are associated with the bacterial envelope or which are secreted.

Thus, in a first aspect the present invention provides a Streptococcus pneumoniae protein or polypeptide having a sequence selected from those shown in table 1.

In a second aspect, the present invention provides a Streptococcus pneumoniae protein or polypeptide having a sequence selected from those shown in table 2.

A protein or polypeptide of the present invention may be provided in substantially pure form. For example, it may be provided in a form which is substantially free of other proteins.

As discussed herein, the proteins and polypeptides of the invention are useful as antigenic material. Such material can be “antigenic” and/or “immunogenic”,. Generally, “antigenic” is taken to mean that the protein or polypeptide is capable of being used to raise antibodies or indeed is capable of inducing an antibody response in a subject. “Immunogenic” is taken to mean that the protein or polypeptide is capable of eliciting a protective immune response in a subject. Thus, in the latter case, the protein or polypeptide may be capable of not only generating an antibody response but, in addition, a non-antibody based immune response.

The skilled person will appreciate that homologues or derivatives of the proteins or polypeptides of the invention will also find use in the context of the present invention, ie as antigenic/immunogenic material. Thus, for instance proteins or polypeptides which include one or more additions, deletions, substitutions or the like are encompassed by the present invention. In addition, it may be possible to replace one amino acid with another of similar “type”. For instance replacing one hydrophobic amino acid with another.

One can use a program such as the CLUSTAL program to compare amino acid sequences. This program compares amino acid sequences and finds the optimal alignment by inserting spaces in either sequence as appropriate. It is possible to calculate amino acid identity or similarity (identity plus conservation of amino acid type) for an optimal alignment. A program like BLASTx will align the longest stretch of similar sequences and assign a value to the fit. It is thus possible to obtain a comparison where several regions of similarity are found, each having a different score. Both types of identity analysis are contemplated in the present invention.

In the case of homologues and derivatives, the degree of identity with a protein or polypeptide as described herein is less important than that the homologue or derivative should retain the antigenicity or immunogenicity of the original protein or polypeptide. However, suitably, homologues or derivatives having at least 60% similarity (as discussed above) with the proteins or polypeptides described herein are provided. Preferably, homologues or derivatives having at least 70% similarity, more preferably at least 80% similarity are provided. Most preferably, homologues or derivatives having at least 90% or even 95% similarity are provided.

In an alternative approach, the homologues or derivatives could be fusion proteins, incorporating moieties which render purification easier, for example by effectively tagging the desired protein or polypeptide. It may be necessary to remove the “tag” or it may be the case that the fusion protein itself retains sufficient antigenicity to be useful.

In an additional aspect of the invention there are provided antigenic/immunogenic fragments of the proteins or polypeptides of the invention, or of homologues or derivatives thereof.

For fragments of the proteins or polypeptides described herein, or of homologues or derivatives thereof, the situation is slightly different. It is well known that is possible to screen an antigenic protein or polypeptide to identify epitopic regions, ie those regions which are responsible for the protein or polypeptide's antigenicity or immunogenicity. Methods for carrying out such screening are well known in the art. Thus; the fragments of the present invention should include one or more such epitopic regions or be sufficiently similar to such regions to retain their antigenic/immunogenic properties. Thus, for fragments according to the present invention the degree of identity is perhaps irrelevant, since they may be 100% identical to a particular part of a protein or polypeptide, homologue or derivative as described herein. The key issue, once again, is that the fragment retains the antigenic/immunogenic properties.

Thus, what is important for homologues, derivatives and fragments is that they possess at least a degree of the antigenicity/immunogenicity of the protein or polypeptide from which they are derived.

Gene cloning techniques may be used to provide a protein of the invention in substantially pure form. These techniques are disclosed, for example, in J. Sambrook et al Molecular Cloning 2nd Edition, Cold Spring Harbor Laboratory Press (1989). Thus, in a third aspect, the present invention provides a nucleic acid molecule comprising or consisting of a sequence which is:

(i) any of the DNA sequences set out in Table 1 or their RNA equivalents;

(ii) a sequence which is complementary to any of the sequences of (i);

(iii) a sequence which codes for the same protein or polypeptide, as those sequences of (i) or (ii);

(iv) a sequence which has substantial identity with any of those of (i), (ii) and (iii);

(v) a sequence which codes for a homologue, derivative or fragment of a protein as defined in Table 1.

In a fourth aspect the present invention provides a nucleic acid molecule comprising or consisting of a sequence which is:

(i) any of the DNA sequences set out in Table 2 or their RNA equivalents;

(ii) a sequence which is complementary to any of the sequences of (i);

(iv) a sequence which has substantial identity with any of those of (i), (ii) and (iii); or

(v) a sequence which codes for a homologue, derivative or fragment of a protein as defined in Table 2.

The nucleic acid molecules of the invention may include a plurality of such sequences, and/or fragments. The skilled person will appreciate that the present invention can include novel variants of those particular novel nucleic acid molecules which are exemplified herein. Such variants are encompassed by the present invention. These may occur in nature, for example because of strain variation. For example, additions, substitutions and/or deletions are included. In addition, and particularly when utilising microbial expression systems, one may wish to engineer the nucleic acid sequence by making use of known preferred codon usage in the particular organism being used for expression. Thus, synthetic or non-naturally occurring variants are also included within the scope of the invention.

The term “RNA equivalent” when used above indicates that a given RNA molecule has a sequence which is complementary to that of a given DNA molecule (allowing for the fact that in RNA “U” replaces “T” in the genetic code).

When comparing nucleic acid sequences for the purposes of determining the degree of homology or identity one can use programs such as BESTFIT and GAP (both from the Wisconsin Genetics Computer Group (GCG) software package) BESTFIT, for example, compares two sequences and produces an optimal alignment of the most similar segments. GAP enables sequences to be aligned along their whole length and finds the optimal alignment by inserting spaces in either sequence as appropriate. Suitably, in the context of the present invention when discussing identity of nucleic acid sequences, the comparison is made by alignment of the sequences along their whole length.

Preferably, sequences which have substantial identity have at least 50% sequence identity, desirably at least 75% sequence identity and more desirably at least 90 or at least 95% sequence identity with said sequences. In some cases the sequence identity may be 99% or above.

Desirably, the term “substantial identity” indicates that said sequence has a greater degree of identity with any of the sequences described herein than with prior art nucleic acid sequences.

It should however be noted that where a nucleic acid sequence of the present invention codes for at least part of a novel gene product the present invention includes within its scope all possible sequence coding for the gene product or for a novel part thereof.

The nucleic acid molecule may be in isolated or recombinant form. It may be incorporated into a vector and the vector may be incorporated into a host. Such vectors and suitable hosts form yet further aspects of the present invention.

Therefore, for example, by using probes based upon the nucleic acid sequences provided herein, genes in Streptococcus pneumoniae can be identified. They can then be excised using restriction enzymes and cloned into a vector. The vector can be introduced into a suitable host for expression.

Nucleic acid molecules of the present invention may be obtained from S. pneumoniae by the use of appropriate probes complementary to part of the sequences of the nucleic acid molecules. Restriction enzymes or sonication techniques can be used to obtain appropriately sized fragments for probing.

Alternatively PCR techniques may be used to amplify a desired nucleic acid sequence. Thus the sequence data provided herein can be used to design two primers for use in PCR so that a desired sequence, including whole genes or fragments thereof, can be targeted and then amplified to a high degree.

Typically primers will be at least 15-25 nucleotides long.

As a further alternative chemical synthesis may be used. This may be automated. Relatively short sequences may be chemically synthesised and ligated together to provide a longer sequence.

There is another group of proteins from S. pneumoniae which have been identified using the bacterial expression system described herein. These are known proteins from S. pneumoniae, which have not previously been identified as antigenic proteins. The amino acid sequences of this group of proteins, together with DNA sequences coding for them are shown in Table 3. These proteins, or homologues, derivatives and/or fragments thereof also find use as antigens/immunogens. Thus, in another aspect the present invention provides the use of a protein or polypeptide having a sequence selected from those shown in Tables 1-3, or homologues, derivatives and/or fragments thereof, as an immunogen/antigen.

In yet a further aspect the present invention provides an immunogenic/antigenic composition comprising one or more proteins or polypeptides selected from those whose sequences are shown in Tables 1-3, or homologues or derivatives thereof, and/or fragments of any of these. In preferred embodiments, the immunogenic/antigenic composition is a vaccine or is for use in a diagnostic assay.

In the case of vaccines suitable additional excipients, diluents, adjuvants or the like may be included. Numerous examples of these are well known in the art.

It is also possible to utilise the nucleic acid sequences shown in Tables 1-3 in the preparation of so-called DNA vaccines. Thus, the invention also provides a vaccine composition comprising one or more nucleic acid sequences as defined herein. DNA vaccines are described in the art (see for instance, Donnelly et al, Ann. Rev. Immunol., 15:617-648 (1997)) and the skilled person can use such art described techniques to produce and use DNA vaccines according to the present invention.

As already discussed herein the proteins or polypeptides described herein, their homologues or derivatives, and/or fragments of any of these, can be used in methods of detecting/diagnosing S. pneumoniae. Such methods can be based on the detection of antibodies against such proteins which may be present in a subject. Therefore the present invention provides a method for the detection/diagnosis of S. pneumoniae which comprises the step of bringing into contact a sample to be tested with at least one protein, or homologue, derivative or fragment thereof, as described herein. Suitably, the sample is a biological sample, such as a tissue sample or a sample of blood or saliva obtained from a subject to be tested.

In an alternative approach, the proteins described herein, or homologues, derivatives and/or fragments thereof, can be used to raise antibodies, which in turn can be used to detect the antigens, and hence S. pneumoniae. Such antibodies form another aspect of the invention. Antibodies within the scope of the present invention may be monoclonal or polyclonal.

Polyclonal antibodies can be raised by stimulating their production in a suitable animal host (e.g. a mouse, rat, guinea pig, rabbit, sheep, goat or monkey) when a protein as described herein, or a homologue, derivative or fragment thereof, is injected into the animal. If desired, an adjuvant may be administered together with the protein. Well-known adjuvants include Freund's adjuvant (complete and incomplete) and aluminium hydroxide. The antibodies can then be purified by virtue of their binding to a protein as described herein.

Monoclonal antibodies can be produced from hybridomas. These can be formed by fusing myeloma cells and spleen cells which produce the desired antibody in order to form an immortal cell line. Thus the well-known Kohler & Milstein technique (Nature 256 (1975)) or subsequent variations upon this technique can be used.

Techniques for producing monoclonal and polyclonal antibodies that bind to a particular polypeptide/protein are now well developed in the art. They are discussed in standard immunology textbooks, for example in Roitt et al, Immunology second edition (1989), Churchill Livingstone, London.

In addition to whole antibodies, the present invention includes derivatives thereof which are capable of binding to proteins etc as described herein. Thus the present invention includes antibody fragments and synthetic constructs. Examples of antibody fragments and synthetic constructs are given by Dougall et al in Tibtech 12 372-379 (September 1994).

Antibody fragments include, for example, Fab, F(ab′) ₂and Fv fragments. Fab fragments (These are discussed in Roitt et al [supra]). Fv fragments can be modified to produce a synthetic construct known as a single chain Fv (scFv) molecule. This includes a peptide linker covalently joining V_hand V_lregions, which contributes to the stability of the molecule. Other synthetic constructs that can be used include CDR peptides. These are synthetic peptides comprising antigen-binding determinants. Peptide mimetics may also be used. These molecules are usually conformationally restricted organic rings that mimic the structure of a CDR loop and that include antigen-interactive side chains.

Synthetic constructs include chimaeric molecules. Thus, for example, humanised (or primatised) antibodies or derivatives thereof are within the scope of the present invention. An example of a humanised antibody is an antibody having human framework regions, but rodent hypervariable regions. Ways of producing chimaeric antibodies are discussed for example by Morrison et al in PNAS, 81, 6851-6855 (1984) and by Takeda et al in Nature. 314, 452454 (1985).

Synthetic constructs also include molecules comprising an additional moiety that provides the molecule with some desirable property in addition to antigen binding. For example the moiety may be a label (e.g. a fluorescent or radioactive label). Alternatively, it may be a pharmaceutically active agent.

Antibodies, or derivatives thereof, find use in detection/diagnosis of S. pneumoniae. Thus, in another aspect the present invention provides a method for the detection/diagnosis of S. pneumoniae which comprises the step of bringing into contact a sample to be tested and antibodies capable of binding to one or more proteins described herein, or to homologues, derivatives and/or fragments thereof.

In addition, so-called “Affibodies” may be utilised. These are binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain (Nord et al,) Thus, Small protein domains, capable of specific binding to different target proteins can be selected using combinatorial approaches.

It will also be clear that the nucleic acid sequences described herein may be used to detect/diagnose S. pneumoniae. Thus, in yet a further aspect, the present invention provides a method for the detection/diagnosis of S. pneumoniae which comprises the step of bringing into contact a sample to be tested with at least one nucleic acid sequence as described herein. Suitably, the sample is a biological sample, such as a tissue sample or a sample of blood or saliva obtained from a subject to be tested. Such samples may be pretreated before being used in the methods of the invention. Thus, for example, a sample may be treated to extract DNA. Then, DNA probes based on the nucleic acid sequences described herein (ie usually fragments of such sequences) may be used to detect nucleic acid from S. pneumoniae.

In additional aspects, the present invention provides:

(a) a method of vaccinating a subject against S. pneumoniae which comprises the step of administering to a subject a protein or polypeptide of the invention, or a derivative, homologue or fragment thereof, or an immunogenic composition of the invention;

(b) a method of vaccinating a subject against S. pneumoniae which comprises the step of administering to a subject a nucleic acid molecule as defined herein;

(c) a method for the prophylaxis or treatment of S. pneumoniae infection which comprises the step of administering to a subject a protein or polypeptide of the invention, or a derivative, homologue or fragment thereof, or an immunogenic composition of the invention;

(d) a method for the prophylaxis or treatment of S. pneumoniae infection which comprises the step of administering to a subject a nucleic acid molecule as defined herein;

(e) a kit for use in detecting/diagnosing S. pneumoniae infection comprising one or more proteins or polypeptides of the invention, or homologues, derivatives or fragments thereof, or an antigenic composition of the invention; and

(f) a kit for use in detecting/diagnosing S. pneumoniae infection comprising one or more nucleic acid molecules as defined herein.

Given that we have identified a group of important proteins, such proteins are potential targets for anti-microbial therapy. It is necessary, however, to determine whether each individual protein is essential for the organism's viability. Thus, the present invention also provides a method of determining whether a protein or polypeptide as described herein represents a potential anti-microbial target which comprises antagonising, inhibiting or otherwise interfering with the function or a expression of said protein and determining whether S. pneumoniae is still viable.

A suitable method for inactivating the protein is to effect selected gene knockouts, ie prevent expression of the protein and determine whether this results in a lethal change. Suitable methods for carrying out such gene knockouts are described in Li et al, P.N.A.S., 94:13251-13256 (1997) and Kolkman et al, 178:3736-3741(1996).

In a final aspect the present invention provides the use of an agent capable of antagonising, inhibiting or otherwise interfering with the function or expression of a protein or polypeptide of the invention in the manufacture of a medicament for use in the treatment or prophylaxis of S. pneumoniae infection.

As mentioned above, we have used a bacterial expression system as a means of identifying those proteins which are surface associated, secreted or exported and thus, would find use as antigens.

The information necessary for the secretion/export of proteins has been extensively studied in bacteria. In the majority of cases, protein export requires a signal peptide to be present at the N-terminus of the precursor protein so that it becomes directed to the translocation machinery on the cytoplasmic membrane. During or after translocation, the signal peptide is removed by a membrane associated signal peptidase. Ultimately the localization of the protein (i.e. whether it be secreted, an integral membrane protein or attached to the cell wall) is determined by sequences other than the leader peptide itself.

We are specifically interested in surface located or exported proteins as these are likely to be antigens for use in vaccines, as diagnostic reagents or as targets for therapy with novel chemical entities. We have therefore developed a screening vector-system in Lactococcus lactis that permits genes encoding exported proteins to be identified and isolated. We provide below a representative example showing how given novel surface associated proteins from Streptococcus pneumoniae have been identified and characterized. The screening vector incorporates the staphylococcal nuclease gene nuc lacking its own export signal as a secretion reporter. Staphylococcal nuclease is a naturally secreted heat-stable, monomeric enzyme which has been efficiently expressed and secreted in a range of Gram positive bacteria (Shortle, Gene, 22:181-189 (1983); Kovacevic et al., J. Bacteriol., 162:521-528 (1985); Miller et al., J. Bacteriol., 169:3508-3514 (1987); Liebl et al., J. Bacterol., 174:1854-1861 (1992); Le Loir et al., J. Bacteriol., 176:5135-5139 (1994); Poquet et al., J. Bacteriol., 180:1904-1912 (1998)).

Recently, Poquet et al. ((1998), supra) have described a screening vector incorporating the nuc gene lacking its own signal leader as a reporter to identify exported proteins in Gram positive bacteria, and have applied it to L. lactis. This vector (pFUN) contains the pAMβ1 replicon which functions in a broad host range of Gram-positive bacteria in addition to the ColE1 replicon that promotes replication in Escherichia coli and certain other Gram negative bacteria. Unique cloning sites present in the vector can be used to generate transcriptional and translational fusions between cloned genomic DNA fragments and the open reading frame of the truncated nuc gene devoid of its own signal secretion leader. The nuc gene makes an ideal reporter gene because the secretion of nuclease can readily be detected using a simple and sensitive plate test: Recombinant colonies secreting the nuclease develop a pink halo whereas control colonies remain white (Shortle, (1983), supra; Le Loir et al., (1994), supra).

Thus, the invention will now be described with reference to the following representative example, which provides details of how the proteins, polypeptides and nucleic acid sequences described herein identified as antigenic targets.

We describe herein the construction of three reporter vectors and their use in L. lactis to identify and isolate genomic DNA fragments from Streptococcus pneumoniae encoding secreted or surface associated proteins.

The invention will now be described with reference to the examples, which should not be construed as in any way limiting the invention. The examples refer to the figures in which: [0075]
FIG. 1: shows the results of a number of DNA vaccine trials; and [0076]
FIG. 2: shows the results of further DNA vaccine trials.[0077]

EXAMPLE 1

(i) Construction of the pTREP1-nuc Series of Reporter Vectors [0078]
(a) Construction of Expression Plasmid PTREP1 [0079]
The pTREP1 plasmid is a high-copy number (40-80 per cell) theta-replicating gram positive plasmid, which is a derivative of the pTREX plasmid which is itself a derivative of the previously published pIL253 plasmid. pIL253 incorporates the broad Gram-positive host range replicon of pAMβ1 (Simon and Chopin, [0080] Biochimie, 70:559-567 (1988)) and is non-mobilisable by the L lactis sex-factor. pIL253 also lacks the tra function which is necessary for transfer or efficient mobilisation by conjugative parent plasmids exemplified by pIL501. The Enterococcal pAMβ1 replicon has previously been transferred to various species including Streptococcus, Lactobacillus and Bacillus species as well as Clostridium acetobutylicum, (Oultram and Klaenhammer, FEMS Microbiological Letters, 27:129-134 (1985); Gibson et al., (1979); LeBlanc et al., Proceedings of the National Academy of Science USA, 75:3484-3487 (1978)) indicating the potential broad host range utility. The pTREP1 plasmid represents a constitutive transcription vector.
The pTREX vector was constructed as follows. An artificial DNA fragment containing a putative RNA stabilising sequence, a translation initiation region (TIR), a multiple cloning site for insertion of the target genes and a transcription terminator was created by annealing 2 complementary oligonucleotides and extending with Tfl DNA polymerase. The sense and anti-sense oligonucleotides contained the recognition sites for NheI and BamHI at their 5′ ends respectively to facilitate cloning. This fragment was cloned between the XbaI and BamHI sites in pUC19NT7, a derivative of pUC19 which contains the T7 expression cassette from pLET1 (Wells et al, [0081] J. Appl. Bacteriol., 74:629-636 (1993)) cloned between the EcoRI and HindIII sites. The resulting construct was designated pUCLEX. The complete expression cassette of pUCLEX was then removed by cutting with HindIII and blunting followed by cutting with EcoRI before cloning into EcoRI and SacI (blunted) sites of pIL253 to generate the vector pTREX (Wells and Schofield, In Current advances in metabolism, genetics and applications-NATO ASI Series, H 98:37-62 (1996)). The putative RNA stabilising sequence and TIR are derived from the Escherichia coli T7 bacteriophage sequence and modified at one nucleotide position to enhance the complementarity of the Shine Dalgarno (SD) motif to the ribosomal 16s RNA of Lactococcus lactis (Schofield et al. pers. corns. University of Cambridge Dept. Pathology.).
A [0082] Lactococcus lactis MG1363 chromosomal DNA fragment exhibiting promoter activity which was subsequently designated P7 was cloned between the EcoRI and BglII sites present in the expression cassette, creating pTREX7. This active promoter region had been previously isolated using the promoter probe vector pSB292 (Waterfield et al, Gene, 165:9-15 (1995)). The promoter fragment was amplified by PCR using the Vent DNA polymerase according to the manufacturer.
The pTREP1 vector was then constructed as follows. An artificial DNA fragment which included a transcription terminator, the forward pUC sequencing primer, a promoter multiple -cloning site region and a universal translation stop sequence was created by annealing two overlapping partially complementary synthetic oligonucleotides together and extending with sequenase according to manufacturers instructions. The sense and anti-sense (pTREP[0083] _Fand pTREP_R) oligonucleotides contained the recognition sites for EcoRV and BamHI at their 5′ ends respectively to facilitate cloning into pTREX7. The transcription terminator was that of the Bacillus penicillinase gene, which has been shown to be effective in Lactococcus (Jos et al., Applied and Environmental Microbiology, 50:540-542 (1985)). This was considered necessary as expression of target genes in the pTREX vectors was observed to be leaky and is thought to be the result of cryptic promoter activity in the origin region (Schofield et al. pers. coms. University of Cambridge Dept. Pathology.). The forward pUC primer sequencing was included to enable direct sequencing of cloned DNA fragments. The translation stop sequence which encodes a stop codon in 3 different frames was included to prevent translational fusions between vector genes and cloned DNA fragments The pTREX7 vector was first digested with EcoRI and blunted using the 5′-3′ polymerase activity of T4 DNA polymerase (NEB) according to manufacturer's instructions. The EcoRI digested and blunt ended pTREX7 vector was then digested with Bgl II thus removing the P7 promoter. The artificial DNA fragment derived from the annealed synthetic oligonucleotides was then digested with EcoRV and Bam HI and cloned into the EcoRI(blunted)-Bgl II digested pTREX7 vector to generate pTREP. A Lactococcus lactis MG1363 chromosomal promoter designated P1 was then cloned between the EcoRI and BglII sites present in the pTREP expression cassette forming pTREP1. This promoter was also isolated using the promoter probe vector pSB292 and characterised by Waterfield et al., (1995), supra. The P1 promoter fragment was originally amplified by PCR using vent DNA polymerase according to manufacturers instructions and cloned into the pTREX as an EcoRI-BglII DNA fragment. The EcoRI-BglII P1 promoter containing fragment was removed from pTREX1 by restriction enzyme digestion and used for cloning into pTREP (Schofield et al. pers. coms. University of Cambridge, Dept. Pathology.).
(b) PCR Amplification of the [0084] S. aureus nuc Gene.
The nucleotide sequence of the [0085] S. aureus nuc gene (EMBL database accession number V01281) was used to design synthetic oligonucleotide primers for PCR amplification. The primers were designed to amplify the mature form of the nuc gene designated nucA which is generated by proteolytic cleavage of the N-terminal 19 to 21 amino acids of the secreted propeptide designated Snase B (Shortle, (1983), supra). Three sense primers (nucS1, nucS2 and nucS3, Appendix 1) were designed, each one having a blunt-ended restriction endonuclease cleavage site for EcoRV or SmaI in a different reading frame with respect to the nuc gene. Additionally BglII and BamHI were incorporated at the 5′ ends of the sense and anti-sense primers respectively to facilitate cloning into BamHI and BglII cut pTREP1. The sequences of all the primers are given in Appendix 1. Three nuc gene DNA fragments encoding the mature form of the nuclease gene (NucA) were amplified by PCR using each of the sense primers combined with the anti-sense primer described above. The nuc gene fragments were amplified by PCR using S. aureus genomic DNA template, Vent DNA Polymerase (NEB) and the conditions recommended by the manufacturer. An initial denaturation step at 93° C. for 2 min was followed by 30 cycles of denaturation at 93° C. for 45 sec, annealing at 50° C. for 45 seconds, and extension at 73° C. for 1 minute and then a final 5 Tin extension step at 73° C. The PCR amplified products were purified using a Wizard clean up column (Promega) to remove unincorporated nucleotides and primers.
(c) Construction of the pTREP1-nuc Vectors [0086]
The purified nuc gene fragments described in section b were digested with Bgl II and BamHI using standard conditions and ligated to BamHI and BglII cut and dephosphorylated pTREP1 to generate the pTREP1-nuc1, pTREP1-nuc2 and pTREP1-nuc3 series of reporter vectors. General molecular biology techniques were carried out using the reagents and buffer supplied by the manufacture or using standard conditions (Sambrook and Maniatis, (1989), supra). In each of the pTREP1-nuc vectors the expression cassette comprises a transcription terminator, lactococcal promoter P1, unique cloning sites (BglII, EcoRV or SmaI) followed by the mature form of the nuc gene and a second transcription terminator. Note that the sequences required for translation and secretion of the nuc gene were deliberately excluded in this construction. Such elements can only be provided by appropriately digested foreign DNA fragments (representing the target bacterium) which can be cloned into the unique restriction sites present immediately upstream of the nuc gene. [0087]
In possessing a promoter, the pTREP1-nuc vectors differ from the pFUN vector described by Poquet et al. (1998), supra, which was used to identify [0088] L. lactis exported proteins by screening directly for Nuc activity directly in L. lactis. As the pFUN vector does not contain a promoter upstream of the nuc open reading frame the cloned genomic DNA fragment must also provide the signals for transcription in addition to those elements required for translation initiation and secretion of Nuc. This limitation may prevent the isolation of genes that are distant from a promoter for example genes which are within polycistronic operons. Additionally there can be no guarantee that promoters derived from other species of bacteria will be recognised and functional in L. lactis. Certain promoters may be under stringent regulation in the natural host but not in L. lactis. In contrast, the presence of the P1 promoter in the pTREP1-nuc series of vectors ensures that promoterless DNA fragments (or DNA fragments containing promoter sequences not active in L. lactis) will still be transcribed.
(d) Screening for Secreted Proteins in [0089] S. pneumoniae
Genomic DNA isolated from [0090] S. pneumoniae was digested with the restriction enzyme Tru9I. This enzyme which recognises the sequence 5′-TTAA -3′ was used because it cuts A/T rich genomes efficiently and can generate random genomic DNA fragments within the preferred size range (usually averaging 0.5-1.0 kb). This size range was preferred because there is an increased probability that the PI promoter can be utilised to transcribe a novel gene sequence. However, the PI promoter may not be necessary in all cases as it is possible that many Streptococcal promoters are recognised in L. lactis. DNA fragments of different size ranges were purified from partial Tru9I digests of S. pneumoniae genomic DNA. As the Tru 9I restriction enzyme generates staggered ends the DNA fragments had to be made blunt ended before ligation to the EcoRV or SmaI cut pTREP1-nuc vectors. This was achieved by the partial fill-in enzyme reaction using the 5′-3′ polymerase activity of Klenow enzyme. Briefly Tru9I digested DNA was dissolved in a solution (usually between 10-20 μl in total) supplemented with T4 DNA ligase buffer (New England Biolabs; NEB) (1×) and 33 μM of each of the required dNTPs, in this case dATP and dTTP. Klenow enzyme was added (1 unit Klenow enzyme (NEB) per μg of DNA) and the reaction incubated at 25° C. for 15 minutes. The reaction was stopped by incubating the mix at 75° C. for 20 minutes. EcoRV or SmaI digested pTREP-nuc plasmid DNA was then added (usually between 200400 ng). The mix was then supplemented with 400 units of T4 DNA ligase (NEB) and T4 DNA ligase buffer (1×) and incubated overnight at 16° C. The ligation mix was precipitated directly in 100% Ethanol and {fraction (1/10)} volume of 3M sodium acetate (pH 5.2) and used to transform L. lactis MG1363 (Gasson, 1983). Alternatively, the gene cloning site of the pTREP-nuc vectors also contains a BglII site which can be used to clone for example Sau3AI digested genomic DNA fragments.
[0091] L. lactis transformant colonies were grown on brain heart infusion agar and nuclease secreting (Nuc⁺) clones were detected by a toluidine blue-DNA-agar overlay (0.05 M Tris pH 9.0, 10 g of agar per liter, 10 g of NaCl per liter, 0.1 mM CaCl₂, 0.03% wt/vol. salmon sperm DNA and 90 mg of Toluidine blue 0 dye) essentially as -described by Shortle, 1983, supra and Le Loir et al., 1994, supra). The plates were then incubated at 37° C. for up to 2 hours. Nuclease secreting clones develop an easily identifiable pink halo. Plasmid DNA was isolated from Nuc⁺ recombinant L. lactis clones and DNA inserts were sequenced on one strand using the NucSeq sequencing primer described in Appendix 1, which sequences directly through the DNA insert.
Isolation of Genes Encoding Exported Proteins from [0092] S. pneumoniae
A large number of gene sequences putatively encoding exported proteins in [0093] S. pneumoniae have been identified using the nuclease screening system. These have now been further analysed to remove artefacts. The sequences identified using the screening system have been analysed using a number of parameters.
1. All putative surface proteins were analysed for leader/signal peptide sequences using the software programs Sequencher (Gene Codes Corporation) and DNA Strider (Marck, [0094] Nucleic Acids Res., 16:1829-1836 (1988)). Bacterial signal peptide sequences share a common design. They are characterised by a short positively charged N-terminus (N region) immediately preceding a stretch of hydrophobic residues (central portion-h region) followed by a more polar C-terminal portion which contains the cleavage site α-region). Computer software is available which allows hydropathy profiling of putative proteins and which can readily identify the very distinctive hydrophobic portion (h-region) typical of leader peptide sequences. In addition, the sequences were checked for the presence of or absence of a potential ribosomal binding site (Shine-Dalgarno motif) required for translation initiation of the putative nuc reporter fusion protein.
2. All putative surface protein sequences were also matched with all of the protein/DNA sequences using the publicly databases [OWL-proteins inclusive of SwissProt and GenBank translations]. This allows us to identify sequences similar to known genes or homologues of genes for which some function has been ascribed. Hence it has been possible to predict a function for some of the genes identified using the LEEP system and to unequivocally establish that the system can be used to identify and isolate gene sequences of surface associated proteins. We should also be able to confirm that these proteins are indeed surface related and not artifacts. The LEEP system has been used to identify novel gene targets for vaccine and therapy. [0095]
3. Some of the genes identified proteins did not possess a typical leader peptide sequence and did not show homology with any DNA/protein sequences in the database. Indeed these proteins may indicate the primary advantage of our screening method, i.e. the isolation of atypical surface-related proteins, which may have been missed in all previously described screening protocols or approaches based on sequence homology searches. [0096]
In all cases, only partial gene sequences were initially obtained. Full length genes were obtained in all cases by reference to the TIGR [0097] S. pneumoniae database (www@tigr.org). Thus, by matching the originally obtained partial sequences with the database, we were able to identify the full length gene sequences. In this way, as described herein, three groups of genes were clearly identified, ie a group of genes encoding previously unidentified S. pneumoniae proteins, a second group exhibiting some homology with known proteins from a variety of sources and a third group which encoded known S. pneumoniae proteins, which were, however, not known as antigens.

EXAMPLE 2

Vaccine Trials

pcDNA3.1+ as a DNA Vaccine Vector [0098]
pcDNA3.1+[0099]
The vector chosen for use as a DNA vaccine vector was pcDNA3.1 (Invitrogen) (actually pcDNA3.1+, the forward orientation was used in all cases but may be referred to as pcDNA3.1 here on). This vector has been widely and successfully employed as a host vector to test vaccine candidate genes to give protection against pathogens in the literature (Zhang, et al., Kurar and Splitter, Anderson et al.). The vector was designed for high-level stable and non-replicative transient expression in mammalian cells. pcDNA3.1 contains the ColE1 origin of replication which allows convenient high-copy number replication and growth in [0100] E. coli. This in turn allows rapid and efficient cloning and testing of many genes. The pcDNA3.1 vector has a large number of cloning sites and also contains the gene encoding ampicillin resistance to aid in cloning selection and the human cytomegalovirus (CMV) immediate-early promoter/enhancer which permits efficient, high-level expression of the recombinant protein. The CMV promoter is a strong viral promoter in a wide range of cell types including both muscle and immune (antigen presenting) cells. This is important for optimal immune response as it remains unknown as to which cells types are most important in generating a protective response in vivo. A T7 promoter upstream of the multiple cloning site affords efficient expression of the modified insert of interest and which allows in vitro transcription of a cloned gene in the sense orientation.
Zhang, D., Yang, X., Berry, J. Shen, C., McClarty, G. and Brunham, R. C. (1997) “DNA vaccination with the major outer-membrane protein genes induces acquired immunity to [0101] Chlamydia trachomatis (mouse pneumonitis) infection”. Infection and Immunity, 176, 103540.
Kurar, E. and Splitter, G. A. (1997) “Nucleic acid vaccination of [0102] Brucella abortus ribosomal L7/L12 gene elicits immune response”. Vaccine, 15, 1851-57.
Anderson, R., Gao, X. -M., Papakonstantinopoulou, A., Roberts, M. and Dougan, G. (1996) “Immune response in mice following immunisation with DNA encoding fragment C of tetanus toxin”. [0103] Infection and Immunity, 64, 3168-3173.
Preparation of DNA Vaccines [0104]
Oligonucleotide primers were designed for each individual gene of interest derived using the LEEP system. Each gene was examined thoroughly, and where possible, primers were designed such that they targeted that portion of the gene thought to encode only the mature portion of the gene protein. It was hoped that expressing those sequences that encode only the mature portion of a target gene protein, would facilitate its correct folding when expressed in mammalian cells. For example, in the majority of cases primers were designed such that putative N-terminal signal peptide sequences would not be included in the final amplification product to be cloned into the pcDNA3.1 expression vector. The signal peptide directs the polypeptide precursor to the cell membrane via the protein export pathway where it is normally cleaved off by signal peptidase I (or signal peptidase Id if a lipoprotein). Hence the signal peptide does not make up any part of the mature protein whether it be displayed on the surface of the bacteria surface or secreted. Where an N-terminal leader peptide sequence was not immediately obvious, primers were designed to target the whole of the gene sequence for cloning and ultimately, expression in pcDNA3.1. [0105]
Having said that, however, other additional features of proteins may also affect the expression and presentation of a soluble protein. DNA sequences encoding such features in the genes encoding the proteins of interest were excluded during the design of oligonucleotides. These features included: [0106]
1. LPXTG cell wall anchoring motifs. [0107]
2. LXXC ipoprotein attachment sites. [0108]
3. Hydrophobic C-terminal domain. [0109]
4. Where no N-terminal signal peptide or LXXC was present the start codon was excluded. [0110]
5. Where no hydrophobic C-terminal domain or LPXTG motif was present the stop codon was removed. [0111]
Appropriate PCR primers were designed for each gene of interest and any and all of the regions encoding the above features was removed from the gene when designing these primers. The primers were designed with the appropriate enzyme restriction site followed by a conserved Kozak nucleotide sequence (in most cases(NB except in occasional instances for example ID59) GCCACC was used. The Kozak sequence facilitates the recognition of initiator sequences by eukaryotic ribosomes) and an ATG start codon upstream of the insert of the gene of interest. For example the forward primer using a BamH1 site the primer would begin GCGGGATCCGCCACCATG followed by a small section of the 5′ end of the gene of interest. The reverse primer was designed to be compatible with the forward primer and with a NotI restriction site at the 5′ end in most cases (this site is TTGCGGCCGC) (NB except in occasional instances for example ID59 where a XhoI site was used instead of NotI). [0112]
PCR Primers [0113]
The following PCR primers were designed and used to amplify the truncated genes of interest. [0114]
ID5 [0115]
[0116] Forward Primer 5′
[0117] CGGATCCGCCACCATGGGTCTAATTGAAGACTTAAAAAATCAA 3′
[0118] Reverse Primer 5′ TTGCGGCCGCCAATGCTAGACTAAACACAAGACTCA 3′
ID59 [0119]
[0120] Forward Primer 5′ CGCGGATCCATGAAAAAAATCTATTCATTTTTAGCA 3′
[0121] Reverse Primer 5′ CCCTCGAGGGCTACTTCCGATACATTTTAAACTGTAGG 3′
ID51 [0122]
[0123] Forward Primer 5′ CGGATCCGCCACCATGAGTCATGTCGCTGCAAATG 3′
[0124] Reverse Primer 5′ TTGCGGCCGCATACCAAACGCTGACATCTACG 3′
ID29 [0125]
[0126] Forward Primer 5′ CGGATCCGCCACCATGCAAAAAGAGCGGTATGGTTATG 3′
[0127] Reverse Primer 5′ TTGCGGCCGCACCCCCATTCTTAATCCCTT 3′
ID50 [0128]
[0129] Forward Primer 5′
[0130] CGGATCCGCCACCATGGAGGTATGTGAAATGTCACGTAAA 3′
[0131] Reverse Primer 5′TTGCGGCCGCTTTTACAAAGTCAAGCAAAGCC 3′
Cloning [0132]
The insert along with the flanking features described above was amplified using PCR against a template of genomic DNA isolated from [0133] type 4 S. pneumoniae strain 11886 obtained from the National Collection of Type Cultures. The PCR product was cut with the appropriate restriction enzymes and cloned in to the multiple cloning site of pcDNA3.1 using conventional molecular biological techniques. Suitably mapped clones of the genes of interested were cultured and the plasmids isolated on a large scale (>1.5 mg) using Plasmid Mega Kits (Qiagen). Successful cloning and maintenance of genes was confirmed by restriction mapping and sequencing 700 base pairs through the 5′ cloning junction of each large scale preparation of each construct.
Strain Validation [0134]
A strain of [0135] type 4 was used in cloning and challenge methods which is the strain from which the S. pneumoniae genome was sequenced. A freeze dried ampoule of a homogeneous laboratory strain of type 4 S. pneumoniae strain NCTC 11886 was obtained from the National Collection of Type Strains. The ampoule was opened and the cultured re suspended with 0.5 ml of tryptic soy broth (0.5% glucose, 5% blood). The suspension was subcultured into 10 ml tryptic soy broth (0.5% glucose, 5% blood) and incubated statically overnight at 37° C. This culture was streaked on to 5% blood agar plates to check for contaminants and confirm viability and on to blood agar slopes and the rest of the culture was used to make 20% glycerol stocks. The slopes were sent to the Public Health Laboratory Service where the type 4 serotype was confirmed.
A glycerol stock of NCTC 11886 was streaked on a 5% blood agar plate and incubated overnight in a CO[0136] ₂gas jar at 37° C. Fresh streaks were made and optochin sensitivity was confirmed.
Pneumococcal Challenge [0137]

A standard inoculum of type 4 S. pneumoniae was prepared and frozen down by passaging a culture of pneumococcus 1× through mice, harvesting from the blood of infected animals, and grown up to a predetermined viable count of around 10⁹cfu/ml in broth before freezing down. The preparation is set out below as per the flow chart.



Streak pneumococcal culture and confirm identity
\|
V
Grow over-night culture from 4-5 colonies on plate above
\|
V
Animal passage pneumococcal culture
(i.p. injection of cardiac bleed to harvest)
\|
V
Grow over-night culture from animal passaged pneumococcus
\|
V
Grow day culture (to pre-determined optical density) from over-night of
animal passage and freeze down at −70° C. - This is standard
minimum
\|
V
Thaw one aliquot of standard inoculum to viable count
\|
V
Use standard inoculum to determine effective dose (called Virulence
Testing)
\|
V

All subsequent challenges—use standard inoculum to effective dose [0139]
An aliquot of standard inoculum was diluted 500× in PBS and used to inoculate the mice. [0140]
Mice were lightly anaesthetised using halothane and then a dose of 1.4×10[0141] ⁵cfu of pneumococcus was applied to the nose of each mouse. The uptake was facilitated by the normal breathing of the mouse, which was left to recover on its back.
[0142] S. pneumoniae Vaccine Trials
Vaccine trials in mice were carried out by the administration of DNA to 6 week old CBA/ca mice (Harlan, UK). Mice to be vaccinated were divided into groups of six and each group was immunised with recombinant pcDNA3.1+ plasmid DNA containing a specific target-gene sequence of interest. A total of 100 Ag of DNA in Dulbecco's PBS (Sigma) was injected intramuscularly into the tibialis anterior muscle of both legs (50 μl in each leg). A boost was carried using the [0143] same procedure 4 weeks later. For comparison, control groups were included in all vaccine trials. These control groups were either unvaccinated animals or those administered with non-recombinant pcDNA3.1+ DNA (sham vaccinated) only, using the same time course described above. 3 weeks after the second immunisation, all mice groups were challenged intra-nasally with a lethal dose of S. pneumoniae serotype 4 (strain NCTC 11886). The number of bacteria administered was monitored by plating serial dilutions of the inoculum on 5% blood agar plates. A problem with intranasal immunisations is that in some mice the inoculum bubbles out of the nostrils, this has been noted in results table and taken account of in calculations. A less obvious problem is that a certain amount of the inoculum for each mouse may be swallowed. It is assumed that this amount will be the same for each mouse and will average out over the course of inoculations. However, the sample sizes that have been used are small and this problem may have significant effects in some experiments. All mice remaining after the challenge were killed 3 or 4 days after infection. During the infection process, challenged mice were monitored for the development of symptoms associated with the onset of S. pneumoniae induced-disease. Typical symptoms in an appropriate order included piloerection, an increasingly hunched posture, discharge from eyes, increased lethargy and reluctance to move. The latter symptoms usually coincided with the development of a moribund state at which stage the mice were culled to prevent further suffering. These mice were deemed to be very close to death, and the time of culling was used to determine a survival time for statistical analysis. Where mice were found dead, the survival time was taken as the last time point when the mouse was monitored alive.
Interpretation of Results [0144]
A positive result was taken as any DNA sequence that was cloned and used in challenge experiments as described above which gave protection against that challenge. Protection was taken as those DNA sequences that gave statistically significant protection (to a 95% confidence level (p<0.05)) and also those which were marginal or close to significant using Mann-Whitney or which show some protective features for example there were one or more outlying mice or because the time to the first death was prolonged. It is acceptable to allow marginal or non-significant results to be considered as potential positives when it is considered that the clarity of some of the results may be clouded by the problems associated with the administration of intranasal infections. [0145]
Results [0146]

Trials 1-6 (see FIG. 1)



	Mean survival times (hours)

Unvacc

Mouse	control	pcDNA	ID5	control	ID59	control	ID59	control	ID51
number	(1)	3.1 + (1)	(1)	(2)	(2)	(5)	(5)	(6)	(6)

1	47.5	61.0	61.0	49.0	55.0	58.0	55.3	71.6*	50.0
2	57.0	47.5	61.0	51.0	55.0	75.0	98.0	60.7	99.9T
3	47.5	50.5	57.0	49.0	55.0	48.0	58.5	98.5	53.6
4	47.5	50.5	72.0	55.0	69.5	46.7	55.3	(101.2)*T	99.9
5	77.0	72.0	47.5	49.0	74.0	58.0	53.5	60.7	59.4
6	57.0	50.5	mouse	49.0	mouse	75.0	98.0	50.8	50.0*
			died		died
Mean	55.6	55.3	59.7	50.3	61.7	60.1	69.8	68.4	68.8
sd	11.5	9.4	8.8	2.4	9.3	12.5	21.9	18.3	24.4
p value 1	—	—	0.1722	—	0.0064	—	0.2862	—	<36.0
p value 2	—	—	0.2565	—	—	—	—	—	—

Statistical Analyses. [0148]
[0149] Trial 1—None of the other groups had significantly longer survival times than the controls. The survival times of the unvaccinated and pcDNA3. 1 control groups were not significantly different. One of the mice from ID5 was an outlying result and the mean survival times for ID5 were extended but not significantly so.
[0150] Trial 2—The group vaccinated with ID59 had significantly longer survival times than the unvaccinated control group.
[0151] Trial 5—The group vaccinated with ID59 again survived for an average of almost 10 hours longer than the controls but the results were not quite statistically significant.
[0152] Trial 6—The group vaccinated with ID51 did not have survival times significantly higher than unvaccinated controls (p=<36.0), however, there were 2 outlying mice in the vaccinated group.

Vaccine Trials 7 and 8 (See FIG. 2)



	Mean survival times (hours)

Mouse	Unvacc	ID29	Unvacc	ID50
number	control (7)	(7)	control (8)	(8)

1	59.6	73.1	45.1	60.6
2	47.2	54.8	50.8	60.6
3	59.6	59.3	60.4	51.1
4	70.9	54.8*	55.2	60.6
5	68.6*	59.3	45.1	60.6
6	76.0	54.8	45.1	60.6
Mean	63.6	59.35	50.2	59.1
sd	10.3	7.1	6.4	3.9
p value 1	—	<39.0	—	0.0048

Numbers in brackets—survival times disregarded assuming incomplete dosing [0154]
[0155] p value 1 refers to significance tests compared to unvaccinated controls
Statistical Analyses. [0156]
[0157] Trial 7—The ID29 vaccinated group showed prolonged times to the first death. T
[0158] Trial 8—The group vaccinated with ID50 survived significantly longer than unvaccinated controls.
[0159] Appendix 1—Oligonucleotide Primers

nucS1


Bgl II Eco RV
5′-cgagatctgatatctcacaaacagataacggcgtaaatag-3′

nucS2
Bgl II Sma I
5′-gaagatcttccccgggatcacaaacagataacggcgtaaatag-3′

nucS3
Bgl II Eco RV
5′-cgagatctgatatccatcacaaacagataacggcgtaaatag-3′

nucR
Bam HI

5′-cgggatccttatggacctgaatcagcgttgtc-3′

NucSeq

5′-ggatgctttgtttcaggtgtatc-3′

pTREP
_F
5′-catgatatcggtacctcaagctcatatcattgtccggcaatggtgtg
ggctttttttgttttagcggataacaatttcacac-3′

pTREP
_R
5′-gcggatcccccgggcttaattaatgtttaaacactagtcgaagatct
cgcgaattctcctgtgtgaaattgttatccgcta-3′

PUC
_F
5′-cgccagggttttcccagtcacgac-3′

V
_R
5′-tcaggggggcggagcctatg-3′

V
₁
5′-tcgtatgttgtgtggaattgtg-3′

V
₂
5′-tccggctcgtatgttgtgtggaattg-3′

TABLE 1


ID4 1200 bp
ATGAGAAATATGTGGGTTGTAATCAAGGAAACCTATCTTCGACATGTCGAGTCATGGAGTTTCTTCTTTATGGTGA

TTTCGCCGTTCCTCTTTTTAGGAATCTCTGTAGGAATTGGGCATCTCCAAGGTTCTTCTATGGCTAAAAATAATAA

AGTGGCAGTAGTGACAACAGTGCCATCTGTAGCAGAAGGACTGAAGAATGTAAATGGTGTTAACTTCGACTATAA

AGACGAAGCAAGTGCCAAAGAAGCAATTAAAGAAGAAAAATTAAAAGGTTATTTGACCATTGATCAAGAAGATA

GTGTTCTAAAGGCAGTTTATCTGGCGAAACATCGCTTGAAAATGGAATTAAATTTGAGGTTACAGGTACACTCA

ATGAACTGCAAAATCAGCTTAATCGTTCAACTGCTTCCTTGTCTCAAGAGCAGGAAAAACGCTTAGCGCAGACAA

TTCAATTCACAGAAAAGATTGATGAAGCCAAGGAAAATAAAAAGTTTATTCAAACAATTGCAGCAGGTGCCTTAG

GATTCTTTCTTTATATGATTCTGATTACCTATGCGGGTGTAACAGCTCAGGAAGTTGCCAGTGAAAAAGGCACCAA

AATTATGGAAGTCGTTTTTTCTAGCATAAGGGCAAGTCACTATTTCTATGCGCGGATGATGGCTCTGTTTCTAGTG

ATTTTAACGCATATTGGGATCTATGTTGTAGGTGGTCTGGCTGCCGTTTTGCTCTTTAAAGATTTGCCATTCTTGGC

TCAGTCTGGTATTTTGGATCACTTGGGAGATGCTATCTCACTGAATACCTTGCTCTTTATTTTGATCAGTCTTTTCA

TGTACGTAGTCTTGGCAGCCTTCCTAGGATCTATGGTTTCTCCTCCTGAGGACTCAGGGAAAGCCTTGTCGCCTTT

GATGATTTTGATTATGGGTGGTTTTTTTGGAGTGACAGCTCTAGGTGCAGCTGGTGACAATCTCCTCTTGAAGATT

GGTTCTTATATTCCCTTTATTTCGACCTTCTTTATGCCGTTTCGAACGATTAATGACTATGCGGGGGGAGCAGAAG

CATGGATTTCACTTGCTATTACAGTGATTTTTGCGGTGGTAGCAACAGGATTTATCGGACGCATGTATGCTAGTCT

CGTTCTTCAAACGGATGATTTAGGGATTTGGAAAACCTTTAAACGTGCCTTATCTTATAAATAG

MRNMWVVIKETYLRHVESWSFFFMVISPFLFLGISVGIGHLQGSSMAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKD

RASAKEAIKEEKLKGYLTIDQEDSVLKAVYHGETSLENGIKFEVTGTLNELQNQNRSTASLSQEQEKRLAQTIQFTEKI

DEAKENKKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRASHYFYARMMALFLVILTHIGIYVVG

GLAAVLLFKDLPFLAQSGILDHLGDAISLNTLLFILISLFMYVVLAAFLGSMVSRPEDSGKALSPLMILIMGGFFGVTALG

AAGDNLLLKIGSYIPFISTFFMPFRTINDYAGGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTFKRALSYK

Z

ID5 1125 bp
CCTGGGAAAGTCTTGAAAATTATGATAGAATGGTGGAAGGAAAAATTCAGGAGAGTAGTAGTGACTCAAAATGTT

GAAAGTCTTCTCGTATCCATTGTAATCAGTGCATACAATGAAGAAAAATATCTGCCTGGTCTAATTGAAGACTTAA

AAAATCAAACCTATCCTAAAGAGGATATTGAAATTCTATTTATAAATGCTATGTCCACAGATGGGACCACAGTA

TCATTCAGCAATTTATAAAGGAAGATACAGAGTTAACTCAATTAGATTGTATAACAATCCTAAGAAAAATCAAG

CTAGTGGTTTTAACCTGGGAGTTAAACATTCTGTAGGGGACCTTATTTTAAAAATTGATGCTCATTCAAAAGTTAC

TGAGACTTTTGTAATGAACAATGTGGCTATTATTCAACAAGGTGAATTTGTCTGTGGGGGGCCTAGACCGACGATT

GTCGAAGGAAAAGGAAAATGGGCAGAGACCTTGCATCTTGTTGAGGAAAATATGTTTGGCAGTAGCATTGCCAAT

TATCGAAATAGTTCTGAGGATAGATATGTTTCTTCTATTTTTCATGGAATGTATAAACGAGAGGTTTTCCAGAAGG

TTGGTTTAGTAAATGAGCAACTTGGCCGAACTGAAGATAATGATATTCATTATAGAATTCGAGAATATGGTTATAA

AATCCGCTATGCCCAAGTATTCTATCTTATCAGTATATTCGACCAACATTCAAGAAAATGCTGCATCAAAAGTAT

TCAAATGGTTTGTGGATTGGCTTGACAAGTCATGTTCAGTTTAAGTGTTTATCATTATTTCACTATGTTCCTTGTTT

ATTTGTTTTGAGTCTTGTGTTTAGTCTAGCATTGTTACCGATCACATTCGTATTCATAACTTTACTATTAGGTGCCT

ATTTTCTACTTTTGTCATTACTCACTTTGCTGACTTTATTAAAACATAAAAATGGATTTCTAATTGTGATGCCCTTT

ATTTTATTTTCCATTCACTTTGCTTATGGCCTTGGGACGATTGTAGGTTTAATTAGAGGATTTAAATGGAGAAGG

AGTACAAGAGAACAATAATTTATTTGGATAAAATAAGCCAAATAAATCAAAATATGCTATAA

PGKVLKIMIEWWKEKTRRVVVTQNVESLLVSIVISAYNEEKYLPGLIEDLKNQTYPKEDIENAMTGTAIIQQFIK

EDTEPNSIRLYNNPKKNQASGTNLGVKHSVGDLILKIDAHSKTETTVMNNVAIIQQGETCGGPPTIVEGKGKWAT

LHLVEENMTGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNEQLGRTEDNDIHYRIREYGYKIRYSPSILSYQIRP

TFKKMLHQKYSNGLWIGLTSHVQFKCLSFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLTLLTLLKHKNGF

LIVMPFILFSIHFAYGLGTIVGLIRGFKWKKEYKRTIIYLDKISQINQNMT

ID11 696 bp
ATGATGAAAGAACAAAATACGATAGAAATCGATGTATTTCAATTAGTTAAAAGCTTGTGGAAACGCAAGCTAATG

ATTTTAATAGTGGCACTTGTGACAGGTGCGGGGCTTTTGCATATAGCACTTTTATTGTTAAGCCAGAATATACGA

GTACCACGCGAATTTACGTAGTGAATCGCAATCAAGGAGACAAGCCGGGGTTGACAAATCAGGATTTGCAGGCAG

GAACTTATCTGGTAAAAGACTACCGTGAGATTATCCTTTCGCAGGATGTTTTGGAGGAAGTTGTTTCTGATTTGAA

ACTAGATTTGACGCCAAAAGGTTTGGCTAATAAAATTAAAGTGACAGTACCAGTTGATACCCGTATTGTCTCTATT

TCAGTTAATGATCGAGTTCCTGAAGAGGCAAGCCGTATCGCTAACTCTTTGAGAGAAGTAGCTGCTCAAAAAATT

ATCAGTATTACTCGTGTTTCTGACGTGACAACACTGGAGGAGGCAAGGCCGGCGATATCCCCGTCTTCGCCAAAT

ATTAAACGCAATACACTAATTGGTTTTTTGGCAGGGGTGATTGGAACTAGTGTTATAGTTCTTCATCTTGAACTTTT

GGATACTCGTGTGAAACGTCCGGAAGATATCGAAAATACATTGCAGATGACACTTTTGGGAGTTGTGCCAAACTT

GGGTAAGTTGAAATAG

MMKEQNTIEDVFQLVKSLWKRKLMILIVALVTGAGAFAYSTFIVKPEYTSTTRIYVVNRNQGDKPGLTNQDLQAGTYL

VKDYREIILSQDVLEEVVSDLKLDLTPKGLANKIKVTVPVDTRIVSISVNDRVPEEASRIANSLREVAAQKIISITRVSDVT

TLEEARPAISPSSPNIKRNTLIGFLAGVIGTSVIVLHLELLDTRVKRPEDIENTLQMTLLGVVPNLGKLKZ

ID19 555 bp
ATGGTAAAAGTAGCAGTTATATTAGCTCAGGGCTTTGAAGAAATTGAAGCCTTGACAGTTGTAGATGTCTTGCGTC

GAGCCAATATCACATGTGATATGGTTGGTTTTGAAGAGCAAGTAACGGGTTCGCATGCAATCCAAGTAATGAGCAG

ATCATGTCTTTGATGGAGATTTATCAGACTATGATATGATTGTTCTTCCTGGAGGTATGCCTGGTTCTGCACATTTA

CGTGATAATCAGACCTTGATTCAAGAATGCAAAGCTTCGAGCAAGAAGGGAAGAAACTAGCAGCCATTTGTGCG

GCACCAATTGCCCTCAATCAAGCAGAGATATTGAAAAATAAGCGATACACTTGTTATGACGGCGTTCAAGAGCAA

ATCCTTGATGGTCACTACGTCAAGGAAACAGTAGTGGTAGATGGTCAGTTGACAACCAGTCGGGGTCCTTCAACA

GCCCTTGCCTTTGCCTACGAGTTGGTGGAGCAACTAGGAGGGGACGCAGAGAGTTTACGAACAGGAATGCTCTAT

CGAGATGTCTTTGGTAAAAATCAGTAA

MVKVAVILAQGFEEIEALTVVDVLRRANITVDMVGFEEQVTGSHAIQVRADHFDGDLSDYDMIVLPGGMPGSAHLR

DNQTLIQELQSFEQEGKKLAAICAAPIALNQAEILKNKRYTCYDGVQEQILDGHYVKTVVVDGQLTSRGPTALAFA

YELVEQLGGDAESLRTGMLYRDVFGKNQZ

ID27 306 bp
GTGGTAGGGATGGTAGAACCAAACCTAGAAAGCCTTATAAAAGATCTTTACAATCATGCTCGACATGATTTGAGT

GAAGATTTAGTTGCTGCTCTCCTAGAGACTACTAAAAAACTGCCTACTACAAATGAGCAATTGCAGGCAGTTCGTC

TCTCAGGCCTGGTCAATCGTGAATTGCTCCTAAATCCCAAACATCCAGCACCTGAGTTGCTCAACTTGGCTCGCTT

TGTCAAAAGAGAAGAAGCCAAGTACAGAGGAACTGCGACTTCTGCGCTTATGTATGAGGAACTCTTTAAAATGCT

TTGA

MVGMVEPNLESLIKDLYNHARHDLSEDLVAALLEKIITNEQLQAVRLSGLVNRELLLNPKHPAPELLNITARTVK

REEAKYRGTATSALMYEELFKMLZ

ID29 945 bp
TTGTTCTTAAAAAAGGAAAGAGAGGTAATCAGCATGCGTAAATGGACAAAAGGATTTCTCATCTTTGGTGTGGTG

ACTACCGTTATCGGCTTTATCCTGCTTTTTGTAGGTATCCAATCTGACGGGATAAGAGCCTACTTTCCATGTCCAA

CCAACACACGCTCACCATCACAGACTCTTTCGATGATCAAATCCACATTTCTTACCATCCATCTCTTTCTGCTCAC

CATGATCTTATCACCAATCAGAACGATAGAACTCTGAGTCTCACTGATAAGAAACTGTCTGAAACTCCGTTTCTCT

CTTCTGGAATTGGTGGGATTCTTCATATCGCAAGTAGCTACTCTAGTCGTTTTGAAGAAGTTATTCTCCGACTACC

AAAAGGGAGAACTCTAAAAGGGATCAACATCTCAGCCAATCGCGGACAAACCACCATCATAAATGCTAGCCTTGA

AAATGCGACCCTCAATACAAACAGCTATATCCTCCGAATTGAAGGAAGTCGTATCAAAAACAGTAAACTCACAAC

GCCCAATATCGTTAATATCTTTGATACAGTTCTTACAGATAGTCAGCTAGAGTCAACAGAGAATCACTTCCACGCT

GAAAATATCCAAGTCCATGGCAAGGTTGAACTGACTGCCAAAGATTATCTCAGAATCATCCTAGACCAGAAAGAA

AGCCAACGAATTAACTGGGACATCTCAAGCAACTATGGTTCTATCTTCCAATTCACAAGAGAAAAGCCTGAATCA

AGAGGTACGGAATTAAGCAACCCTTACAAAACTGAAAAAACCGATGTCAAGGATCAACTCATTGCGAGATCTGAT

GATAATATTGATCTAATATCCACACCAAGCAGACGTGA

MFLKKEREVISMRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPVYDSRTEKLTFGKEVENLEITLHQHTLTI

TDSFDDQIHISYHPSLSAHHDLITNQNDRTLSLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILRLPKGRTLKGINISANR

GQTTIINASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTENHFHAENIQVHGKVELTAKDYLRIILD

QKESQRINWDISSNYGSIGQFTREKPESRGTELSNPYKTEKTDVKDQLTPTDDNIDLISTPSRRZ

ID30 879 bp
ATGAAACAAGAATGGTTTGAAAGTAATGATTTTGTAAAAACAACAAGCAAGAACAAGCCTGAAGAGCAAGCTCA

AGAGGTTGCAGACAAGGCTGAAGAAACGATAGCCGATCTCGATACACCAATTGAAAAAAATACTCAGTTAGAGG

AGGAAGTCCCTCAAGCTGAAGTCGAATTGGAAAGCCAGCAAGAAGAGAAAATTGAAGCTCCTGAAGACAGTGAA

GCGAGAACAGAAATAGAAGAAAAGAAGGCATCTAATTCTACTGAAGAAGAGCCAGACCTTTCTAAAGAAACAGA

AAAAGTCACTATAGCTGAAGAGAGCCAAGAAGCTCTTCCTCAGCAAAAGCAACCACGAAAGAGCCACTTCTTAT

CAGTAAATCTTTAGAAAGTCCTTATATCCCCGACCAAGCTCCAAAATCTAGGGATAAATGGAAAGAGCAAGTGCT

TGATTTTTGGTCTTGGCTAGTGGAAGCGATCAAATCTCCTACAAGTAAGTTGGAAACAAGTATCACACACAGTTAC

ACAGCCTTTCTCTTGCTCATTCTGTTTTCTGCATCTTCCTTTTTCTTTAGTATCTATCACATCAAACATGCTTACTAT

GGACATATAGCAAGCATTAACAGTCGCTTCCCTGAGCAGCTAGCTCCTTTAACTCTTTTTTCTATCATCTCTATCCT

AGTAGCGACAACACTCTTCTTCTTTTCATTCCTCTTGGGTAGTTTCGTTGTGACACGATTTATCCACCAGGAAAAG

GACTGGACGCTAGACAAGGTTCTCCAACAATATAGTCAACTCTTGGCAATTCCAATCTCCTCACTGCTATTGCTAG

TTTCTTTGCTTTCTTTGATAGCCTACGATTTACAGCCCTCTTGTGTGTGA

MKQEWFESNDFVKTTSKNKPEEQAQEVADKAEETIADLDTPIEKNTQLEEEVPQAEVELESQQEEKIEAPEDSEARTEIE

EKKASNSTEEEPDLSKETEKVTIAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDTWSWLVEAIKS

PTSKLESITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLTLFSIISILVATTLFFFSFLLGSFVVRRFIH

QEKDWTLDKVLQQYSQLLAIPISSLLLLVSLLSLIAYDLQPSCVZ

ID105 990 bp
ATGCAACTCGCTCTTCGGTCTACTCATTGTTCGTCTGGTACAATTTGTTCTTAAAAAAGGAAAGAGAGGTAATCA

GCATGCGTAAATGGACAAAAGGATTTCTCATCTTGGTGTGGTGACTACCGTTATCGGCTTTATCCTGCTTTTTGTA

GGTATCCAATCTGACGGGATTAAGAGCCTACTCCATGTCCAAAGAACCTGTCTATGATAGCCGTACGGAAAAG

CTAACCTTTGGCAAGGAAGTCGAAAACCTAGAAATTACTCTCCACCAACACACGCTCACCATCACAGACTCTTTC

GATGATCAAATCCACATTTCTTACCATCCATCTCTTTCTGCTCACCATGATCTTATCACCAATCAGAACGATAGAA

CTCTGAGTCTCACTGATAAGAAACTGTCTGAAACTCCGTTTCTCTCTTCTGGAATTGGTGGGATTCTTCATATCGC

AAGTAGCTACTCTAGTCGTTTTGAAGAAGTTATTCTCCGACTACCAAAAGGGAGAACTCTAAAATGGGATCAATAT

CTCAGCCAATCGCGGACAAACCACCATCATAAATGCTAGCCTTGAAAATGCGACCCTCAATACAAACAGCTATAT

CCTCCGAATTGAAGGAAGTCGTATCAAAAACAGTAAACTCACAACGCCCAATATCGTTAATATCTTTGATACAGTT

CTTACAGATAGTCAGCTAGAGTCAACAGAGAATCACTTTCCACGCTGAAAATATCCAAGTCCATGGCAAGGTTGAA

CTGACTGCCAAAGATTATCTCAGAATCATCCTAGACCAGAAAGAAAGCCAACGAATTAACTGGGACATCTCAAGC

AACTATGGTTCTATCTTCCAATTCACAAGAGAAAAGCCTGAATCAAGAGGTACGGAATTAAGCAACCCTTACAAA

ACTGAAAAAACCGATGTCAAGGATCAACTCATTGCGAGATCTGATGATAATATTGATCTAATATCCACACCAAGC

AGACGTTTGA

MQLASSVYSLFVWYNLFLKKEREVISMRKWTKGTLITGVVTTVIGTILLTVGIQSDGIKSLLSMSKEPVYDSRTEKLTFG

KEVENLEITLHQHTLTITDSFDDQIHISYHPSLSAHHDLITNQNDRTLSLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVIL

RLPKGRTLKGINISANRGQTTIINASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNFDTVLTDSQLESTENHTHAENIQV

HGKVELTAKDYLRIILDQKESQRINWDISSNYGSITQTTREKPESRGTELSNPYKTEKTDVKDQLIARSDDNIDLISTPSRR

Z

ID107-78 bp
ATGATATGTAAAATGAAGCAGGGAGGGAGCAGGGCGTGCTGGGGATGGAGAGTGGGGGAGGGACGCTGCTATTT

TAATC

MICKMKQGGSRACWGWRVGEGRCYFN

ID109 714 bp
CGATAAAGAGGCCTTGAGTAATCTCAATTTGCAGATTGAAAATGGAGAGATTATGGGCTTGATTGGTCATAATGG

GGCTGGAAAATCGACCACTATAAAATCCCTAGTCAGTATCKTTTCACCCAGCAGTGGTCGTATTTTGGTAGACGGT

CAGGAGTTATCGGAAAATCGCTTGGCTATTAAACGAAAGAITGGCTACGTAGCAGACTCGCCTGACTTATTTTTAC

GCTTAACGGCCAATTGAATTTTGGGAATTGATCGCCTCATCCTATGATCTGAGTAGATCTGACTTGGAGGTAGTCT

AGCTAGGCTATTGAACGTTTTTGATTTTGCTGAAAATCGCTATCAGGTTATTGAAACTCTTTCTCACGGAATGCGT

CAGAAAGTCTTTGTCATCGGAGCACTCTTGTCTGATCCCGATATTTGGGTTTTGGACGAACCCTTGACTGGTTTGG

ATCCCCAGGCTGCCTTTGATTTGAAACAGATGATGAAGGAACATGCACAAAAAGGGAAGACAGTCTTGTTTTCAA

CTCATGTCCTAGAGGTGGCAGAGCAAGTCTGTGATCGGATTGCCATTTTGAAAAAGGGGCATTTGATTTATTGTGG

TAAGGTAGAGGACTTGAGGAAAGACCACCCAGACCAGTCTTTGGAAAGTATCTACCTTAGTCTTGCTGGTAGTAAA

AGAGGAGGTIGCGGATGCGTCTCAAGGTCATTAA

DKEALSNLNLQIENGEIMGLIGHNGAGKSTTIKSLVSIISPSSGRILVDGQELSENRLAIKRKIGYVADSPDLFLRLTANEF

WELIASSYDLSRSDLEASLARLLNVFDFAENRYQVIETLSHGMRQKVFVIGALLSDPDIWVLDEPLTGLDPQAAFDLKQ

MMKEHAQKGKTVLFSTHVLEVAEQVCDRIAILKKGHLIYCGKVEDLRKDHPDQSLESIYLSLAGRKEEVADASQGHZ

ID112 360 bp
ATGGCTGTTTTCAGAGAGAGGAGCAGTACGGAAGACACCAATGGCAAGTCCAATAATGAGACCTATGATGTTT

CCGACGATAGAGATTAAAAGAGTGATACCAGCACCACGCAAGAGTTGTTGCCAGTTTTCAGAAAGAATTTTAGCA

ACTTGGCTAAAGAAACTACTGCTAGTTTCAGTTGTTGTAGCTTCGGCAGGTTGTTCCTTGATCATACGATCCA

TCAAGGCAACTGGTCATCTTGAAATGGTTTCAATGCTGGCATTGATTTGGCTAATACGATTGTCATTTTTACGA

AGCCCGATAGCGATAGCTGTATCTTCTTCCCCAGTTTTGAAACCAGGTTCTACTTGA

MALTSERGAVRKTPMASPIMRPMMVPTIEIKRVIPAPRKSCCQTSERILATWLTZKLLLVSSVVVASAGCSLIIRSIKATWSS

FEMVSMLALIWLIRLSFLRSPIAIAVSSSPVLKPGSTZ

ID 128-3.43
ATGAAATTTAGTAAAAAATATATAGCAGCTGGATCAGCTGTTATCGTATC

CTTGAGTCTATGTGCCTATGCACTAAACCAGCATCGTTCGCAGGAAAATA

AGGACAATAATCGTGTCTCTATGTGGATGGCAGCCAGTCAAGTCAGAAA

AGTGAAAACTTGACACCAGACCAGGTTAGCCAGAAAGAAGGAATTCAGGC

TGAGCAAATTGTAATCAAAATTACAGATCAGGGCTATGTAACGTCACACG

GTGACCACTATCATTACTATAATGGGAAAGTTCCTTATGATGCCCTCTTT

AGTGAAGAACTCTTGATGAAGGATCCAAACTATCAACTTAAAGACGCTGA

TATTGTCAATGAAGTCAAGGGTGGTTATATCATCAAGGTCGATGGAAAAT

ATTATGTCTACCGAAAGATGCAGCTCATGCTGATAATGTTCGAACTAAA

GATGAAATCAATCGTCAAAAACAAGAACATGTCAAAGATAATGAGAAGGT

TAACTCTAATGTTGCTGTAGCAAGGTCTCAGGGACGATATACGACAAATG

ATGGTTATGTCTTTAATCCAGCTGATATTATCGAAGATACGGGTAATGCT

TATATCGTTCCTCATGGAGGTCACTATCACTACATTCCCAAAAGCGATTT

ATCTGCTAGTGAATTAGCAGCAGCTAAAGCACATCTGGCTGGAAAAAATA

TGCAACCGAGTCAGTTAAGCTATCTTCAACAGCTAGTGACAATAACACG

CAATCTGTAGCAAAAGGATCAACTAGCAAGCCAGCAAATAAATCTGAAAA

TCTCCAGAGTCTTTTGAAGGAACTCTATGATTCACCTAGCGCCCAACGTT

ACAGTGAATCAGATGGCCTGGTCTTTGACCCTGCTAAGATTATCAGTCGT

ACACCAAATGGAGTTGCGATTCCGCATGGCGACCATTACCACTTTATTCC

TTACAGCAAGCTTTCTGCCTTAGAAGAAAAGATTGCCAGAATGGTGCCTA

TCAGTGGAACTGGTTCTACAGTTTCTACAAATGCAAAACCTAATGAAGTA

GTGTCTAGTCTAGGCAGTCTTTCAAGCAATCCTTCTTCTTTAACGACAAG

TAAGGAGCTCTCTTCAGCATCTGATGGTTATATTTTTAATCCAAAAGATA

TCGTTGAAGAAACGGCTACAGCTTATATTGTAAGACATGGTGATCATTTC

CATTACATTCCAAAATCAAATCAAATTGGGCAACCGACTCTCCAAACAA

TAGTCTAGCAACACCTTCTCCATCTCTTCCAATCAATCAGGAACTTCAC

ATGAGAAACATGAAGAAGATGGATACGGATTTGATGCTAATCGTATTATC

GCTGAAGATGAATCAGGTTTTGTCATGAGTCACGGAGACCACAATCATTA

TTTCTTCAAGAAGGACTTGACAGAAGAGCAAATTAAGGTGCGCAAAAACA

TTTAG

MKTSKKYIAAGSAVIVSLSLCAYALNQIIRSQENKDNNRVSYVDGSQSSQK

SENLTPDQVSQKEGIQAEQTTTKTTDQGYVTSHGDHYHYYNGKVPYDALF

SEELLMKDPNYQLKDADIVNEVKGGYIIKVDGICYYVYLKDAAHADNVRTK

DEINRQKQEHVKDNEKVNSNVAVARSQGRYTTNDGYVTNPADIIEDTGNA

YIVPHGGHYHYIPKSDLSASELAAAKAHLAGKNMQPSQLSYSSTASDNNT

QSVAKGSTSKPANKSENLQSLLKELYDSPSAQRYSESDGLVTDPAKIISR

TPNGVMPHGDHYHFIPYSKLSALEEKIARMVPISGTGSTVSTNAKPNEV

VSSLGSLSSNPSSLTTSKSASDGYWNPKDIVEETATAYIVRHGDHF

WYIPKSNQIC3QPTLPNNSLATPSPSLPINPGTSHEKHEEDGYGFDANRII

AEDESGTVMSHGDHNHYTTKKDLTEEQIKVRIKNI*

TABLE 2


ID2 840 bp
ATGGGAATTGCTCTAGAAAATGTGAATTTTACATATCAAGAAGGTACTCCCTTAGCTTCAGCAGCTTTGTCGGATG

TTTCTTTGACGATTGAAGATGGCTC1TATACAGCTTTAATTGGGCACACAGGTAGTGGTAAATCAACTATTTTACA

ACTCTTAAATGGTTTATTGGTGCCAAGTCAAGGGAGTGTGAGGGTTTTTGATACCTTAATCACCTCGACTTCTAAA

AATAAAGATATTCGTCAAATTAGAAAACAGGTTGGCTTGGTATTTCAGTTTGCTGAAAACAGATTTTTGAAGAAA

CGGTTTTGAAGGACGTTGCTTTTGGACCGCAAAATTTTGGAGTTTCTGAAGAAGATGCTGTGAAGACTGCGCGTGA

GAAACTGGCTCTGGTTGGAATTGATGAATCACTTTTTGATCGTAGTCCGTTTGAGCTGTCAGGGGGACAAATGAGA

CGTGTTGCCATTGCAGGCATACTTGCCATGGAGCCAGCTATATTAGTCTTAGATGAGCCAACAGCTGGTCTAGATC

CTCTAGGGAGAAAAGAGTTGATGACCCTGTTCAAAAAACTCCACCAGTCAGGGATGACCATCGTCTTGGTAACGC

ATTTGATGGATGATGTTGCTGAATATGCGAATCAAGTCTATGTAATGGAAAAGGGACGTTTAGTAAATGGGGGGCA

AACCAAGTGATGTCTTTCAAGACGTTGTTTATGGAAGAAGTTCAGTTGGGAGTACCTAAAATTACGGCCTTTTG

TAAACGATTGGCTGATAGAGGCGTGTCATTTAAACGATTACCGATTAAGATAGAGGAGTTCAAGGAGTCGCTAAA

TGGATAG

MGIALENVNFTYQEGTPLASAALSDVSLTIEDGSYTALIGHTGSGKSTTLQLLNGLLVPSQGSVRVTDTLTTSTSKNKDIR

QIRKQVGLVFQFAENQIFEETVLKDVATGPQNTGVSEEDAVKTAREKLALVGDESLTDRSPTELSGGQMRRVARGILA

MEPAILVLDEPTAGLDPLGRKELMTLFKKLIIQSGMTTVLVTHLMDDVAEYANQVYVMEKGRLVKGGKPSDVTQDVV

TMEEVQLGVPKTTATCKRLADRGVSTKRLPIKTTETKBSLNGZ

ID 3 6360 bp
TACCCGGTAGTCTTAGCAGACACATCTAGCTCTGAAGATGCTTAAACATCTCTGATAAAGAAAAAGTAGCAGAA

AATAAAGAGAAACATGAAAATATCCATAGTGCTATGGAAACTTCACAGGATTTTAAAGAGAAGAAAACAGCAGTC

ATTAAGGAAAAAGAAGTTGTTAGTAAAAATCCTGTGATAGACAATAACACTAGCAATGAAGAAGCAAAAATCAA

AGAAGAAAATTCCAATAAATCCCAAGGAGATTATACGGACTCATTTGTGAATAAAAACACAGAAAATCCCAAAAA

AGAAGATAAAGTTGTCTATATTGCTGAATTTAAAGATAAAGAATCTGGAGAAAAAGCAATCAAGGACTATCCAG

TCTTAAGAATACAAAAGTTTTATATACTTATGATAGAATTTTTAACGGTAGTGCCATAGAAACAACTCCAGATAAC

TTGGACAAAATTAAACAAATAGAAGGTATTTTCATCGGTTGAAAGGGCACAAAAAGTCCAACCCATGATGAATCAT

GCCAGAAAGGAAATTGGAGTTGAGGAAGCTATTGATTACCTAAAGTCTATCAATGCTCCGTTTGGGAAAAATTTT

GATGGTAGAGGTATGGTCATTTCAAATATCGATACTGGAACAGATTATAGACATAAGGCTATGAGAATCGATGAT

GATGCCAAAGCCTCAATGAGATTTAAAAAAGAAGACTTAAAAGGCACTGATAAAAATTATTGGTTGAGTGATAAA

ATCCCTCATGCGTTCAATTATTATAATGGTGGCAAAATCACTGTAGAAAAATATGATGATGGAAGGGATTATTTTG

ACCCACATGGGATGCATATTGCAGGGATTCTTGCTGGAAATGATACTGAACAAGACATCAAAAACTTTAACGGCA

TAGATGGAATTGCACCTAATGCACAAATTTTCTCTTACAAAATGTATTCTGACGCAGGATCTGGGTTTGCGGGTGA

TGAAACAATGTTTCATGCTATTGAAGATTCTATCAAACACAACGTTGATGTTTGTTCGGTATCATTTGTTTTACA

CCAACAGGTCTTGTAGGTGAGAAATATTGGCAAGCTATTCGGGCATTAAGAAAAGCAGGCATTCCAATGGTTGTC

GCTACGGGTAACTATGCGACTTCTGCTTCAAGTTCTTTCATGGGATTTAGTAGCAAATAATCATCTGATTGACCG

ACACTGGAAATGTAACACGAACTGCAGCACATGAAGATGCGATAGCGGTCGCTTCTGCTAAAAATCTATCAGTTG

AGTTTGATAAAGTTAACATAGGTGGAGAAAGTTTTAAATACAGAAATATAGGGGCCTTTTTTCGATAAGAGTTAT

TCACAACAAATGAAGATGGAACAAAAGCTCCTAGTAAATTAAAATATGTATATATAGGCATGGGGCAAGACCAAG

ATTTGATAGGTTTGGATCTTAGGGGCAAAATTGCAGTAATGGATAGAATTTATACAAAGGATTTAAAAAATGCTTT

TAAAAAAGCTATGGATAAGGGTGCACGCGCCATTATGGTTGTAAATACTGTAAATTACTACAATAGAGATAATTG

GACAGAGCTTCCAGCTATGGGATATGAAGCGGATGAAGGTACTAAAAGTCAAGTGTTTTCAATTTCAGGAGATGA

TGGTGTAAAGCTATGGAACATGATTAATCCTGATAAAAAAACTGAAGTCAAAAGAAATAATAAAGAAGATTTTAA

AGATAAATTGGAGCAATACTATCCAATTGATATGGAAAGTTTTAATTCCAACAAACCGAATGTAGGTGACGAAAA

AGAGATTGACTTTAAGTTTGCACCTGACACAGACAAAGAACTCTATAAAGAAGATATCATCGTTCCAGCAGGATC

TACATCTTGGGGGCCAAGAATAGATTTACTTTTAAAACCCGATGTTTCAGCACCTGGTAAAAATATTAAATCCACG

CTTAATGTTATTAATGGCAAATCAACTTATGGCTATATGTCAGGAACTAGTATGGCGATCCAATCGTGGCAGCTT

CTACTGTTTTGATTAGACCGAAATTAAAGGAAATGCTTGAAAGACCTGTATTGAAAAATCTTAAGGGAGATGACA

AAATAGATCTTACAAGTCTTACAAAAATTGCCCTACAAAATACTGCGCGACCTATGATGGATGCAACTTCTTGGA

AAGAAAAAAGTCAATACTTTGCATCACCTAGACAACAGGGAGCAGGCCTAATTAATGTGGCCAATGCTTTGAGAA

ATGAAGTTGTAGCAACTTTCAAAAACACTGATTCTAAAGGTTTGGTAAACTCATATGGTTCCATTTCTCTTAAAGA

AATAAAAGGTGATAAAAAATACTTTACAATCAAGCTTCACAATACATCAAACAGACCTTTGACTTTTAAAGTTCA

GCATCAGCGATAACTACAGATTCTCTAACTGACAGATTAAAACTTGATGAAACATATAAAGATGAAAAATCTCCA

GATGGTAAGCAAATTGTTCCAGAAATTCACCCAGAAAAAGTCAAAGGAGCAAATATCACATTTGAGCATGATACT

TTCACTATAGGCGCAAATTCTAGCTTTGATTTGAATGCGGTTATAAATGTTGGAGAGGCCAAAAACAAAAATAAA

TTTGTAGAATCATTTATTCATTTTGAGTCAGTGGAAGCGATGGAAGCTCTAAACTCCAGCGGGAAGAAAATAAAC

TTCCAACCTTCTTTGTCGATGCCTCTAATGGGATTTGCTGGGAATTGGAACCACGAACCAATCTGATTAAATGGG

CTTGGGAAGAAGGGTCAAGATCAAAAACACTGGGAGGTTATGATGATGATGGTAAACCGAAAATTCCAGGAACCT

TAAATAAGGGAATTGGTGGAGAACATGGTATAGATAAATTTAATCCAGCAGGAGTTATACAAAATAGAAAAGATA

AAAATACAACATCCCTGGATCAAAATCCAGAATTATTTGCTTTCAATAACGAAGGGATCAACGTCCATCATCAA

GTGGTTCTAAGATTGCTAACATTTATCCTTTAGATTCAAATGGAAATCCTCAAGATGCTCAACTTGAAAGAGGATT

AACACCTTCTCCACTTGTATTAAGAAGTGCAGAAGAAGGATTGATTTCAATAGTAAATACAAATAAAGAGGGAGA

AAATCAAAGAGACTTAAAAGTCATTTCGAGAGAACACTTTATTAGAGGAATTTTAAATTTCTAAAAGCAATGATGC

AAAGGGAATCAAATCATCTAAACTAAAAGTTTGGGGTGACTTGAAGTGGGATGGACTCATCTATAATCCTAGAGG

TAGAGAAGAAAATGCACCAGAAAGTAAGGATAATCAAGATCCTGCTACTAAGATAAGAGGTCAATTTGAACCGAT

TGCGGAAGGTCAATATTTCTATAAATTTAAATATAGATTAACTAAAGATTACCCATGGCAGCTTTCCTATATTCCT

GTAAAAATTGATAACACCGCCCCTAAGATTGTTTCGGTTGATTTTTCAAATCCTGAAAAAATTAAGTTGATTACAA

AGGATACTTATCATAAGGTAAAAGATCAGTATAAGAATGAAACGCTACTTTGCGAGAGATCAAAAAGAACATCCTG

AAAAATTTGACGAGATTGCGAACGAAGTTTGGTATGCTGGCGCCGCTCTTGTTAATGAAGATGGAGAGGTTGAAA

AAAATCTTGAAGTAACTTACGCAGGTGAGGGTCAAGGAAGAAATAGAAAACTTGATAAAGACGGAAATACCATTT

ATGAAATTAAAGGTGCGGGAGATTAAGGGGAAAAATCATTGAAGTCATTGCATTAGATGGTTCTAGCAATTTCA

CAAAGATTCATAGAATTAAATTGCTAATCAGGTGATGAAAAGGGGATGATTTCCTATTATCTAGTAGATCCTGA

TCAAGATTCATCTAAATATCAAAAGCTTGGCGAGATTGCAGAATCTAAATTTAAAAATTTAGGAAATGGAAAAGA

GGGTAGTCTAAAAAAAGATACAACTGCGGTAGAACATCATCATCAAGAAAATGAAGAGTCTATTAAAGAAAAAT

CTAGTTTTACTATTGATAGAAATATTTCAACAATTAGAGACTTTGAAAATAAAGACTTAAAGAAACTCATTAAAAA

GAAATTTAGAGAAGTTGATGKTTTTTACAAGTGAAACTGGTAAGAGAATGGAGGAATACGATTATAAATACGATGA

TAAAGGAAATATAATAGCCTACGATGATGGGACTGATCTAGAATATGAAACTGAGAAACTTGACGAAATCAAATC

AAAAATTTATGGTGTCTAAGTCCGTCTAAAGATGGACACTTTGAAATTCTTGGAAAGATAAGTAATGTTTCTAAA

AATGCCAAGGTATATTATGGGAATAACTATAAATCTATAGAAATCAAAGCGACCAAGTATGATTTCCACTCAAAA

ACGATGACATTTGATCTATACGCTAATATTAATGATATTGTGGATGGATTAGCTTTTGCAGGAGATATGAGATTAT

TTGTTAAAGATAATGATCAGAAAAAAGCTGAAATTAAAATTAGAATGCCTGAAAAAATTAAGGAAACTAAATCAG

AATATCCCTATGTATCAAGTTATGGGAATGTCATAGAATTAGGGGAAGGAGATCTTTCAAAAAACAAACCAGACA

ATTTAACTAAAATGGAATCTGGTAAAATCTATTCTGATTCAGAAAAACAACAATATCTGTTAAAGGATAATATCAT

TCTAAGAAAAGGCTATGCACTAAAAGTGACTACCTATAATCCTGGAAAAACGGATATGTTAGAAGGAAATGGAGT

CTATAGCAAGGAAGATATAGCAAAAATACAAAAGGCCAATCCTAATCTAAGAGCCCTTTCAGAAACAACAATTTA

TGCTGATAGTAGAAATGTTGAAGATGGAAGAAGTACCCAATCTGTATTAATGTCGGCTTTGGACGGCTTTAACATT

ATAAGGTATCAAGTGTTTACATTTAAAATGAACGATAAAGGGGAAGCTATCGATAAAGACGGAAATCTTGTGACA

GATTCTTCTAAACTTGTATTATTTGGTAAGGATGATAAAGAATACACTGGAGAGGATAAGTTCAATGTAGAAGCTA

TAAAAGAAGATGGCTCCATGTTATTTATTGATACCAAACCAGTAAACCTTTCAATGGATAAGAACTACTTTAATCC

ATCTAAATCTAATAAAATTTATGTACGAAATCCAGAATTTTATTTAAGAGGTAAGATTTCTGATAAGGGTGGTTTT

AACTGGGAATTGAGAGTTAATGAATCGGTTGTAGATAATTATTTAATCTACGGAGATTTACACATTGATAACACTA

GAGATTTTAATATTAAGCTGAATGTTAAAGACGGTGACATCATGGACTGGGGAATGAAAGACTATAAAGCAAACG

GATTCCAGATAAGGTAACAGATATGGATGGAAATGTTTATCTTCAAACTGGCTATAGCGATTTGAATGCTAAAGC

AGTTGGAGTCCACTATCAGTTTTATATGATAATGTTAAACCCGAAGTAAACKTTGATCCTAAGGGAAATACTAGT

ATCGAATATGCTGATGGAAAATCTGTAGTCTAACATCAATGATAAAAGAAATTAATGGATTCGNTGGTGAGATT

CAAGAACAACATATATATAAATGGAAAAGAATATACATCATTAATGATATTAAACAAATATAATAGACATGACA

CTAAACATTAAGATTGTTGTAAAAGATTTTGCAAGAAATACAACCGTAAAAGAATTCATTTTAAATAAAGATACG

GGAGAGGTAAGTGAATTAAAACCTCATAGGGTAACTGTGACCATTCAAAATGGAAAAGAAATGAGTTCAACGATA

GTGTCGGAAGAAGATTTTATTTTACCTGTTATAAGGGTGAATTAGAAAAAGGATACCAATTTGATGGTTGGGAAA

TTTCTGGTTTCGAAGGTAAAAAAGACGCTGGCTATGTTATTAATCTATCAAAAGATACCTATAATACCTGTATT

CAAGAAAATAGAGGAGAAAAAGGAGGAAGAAAATAAACCTACTTTTGATGTATCGAAAAGAAAGATATACCCAC

AAGTAAACCATAGTCAATTAAATGAAAGTCACAGAAAAGAGGATTTACAAAGAGAAGAGCATTCACAACAATTCT

GATTCAACTAAGGATGTTACAGCTACAGTTCTGATAAAAACAATATCAGTAGTAAATCAACTACTAACAATCCT

AATAAGTTGCCAAAAACTGGAACAGCAAGCGGAGCCCAGACACTATTAGCTGCCGGAATAATGTTTATAGTAGGA

ATTTTTCTTGGATTTGAAGAAAAAAAATCAAGATTAA

YPVVLADTSSSEDALNISDKEKVAENKEKHENIHSAMETSQFKEKKTAVIKEKEVVSKNPVIDNNTSNEEAKIKEENSN

KSQGDYTDSTVNKNTENPKKEDKVVYIAEFKDKESGEKATKELSSLKNTKVLYTYDRTTNGSAIETTPDNLDKIKQIEGIS

SVERAQKVQPMMNHARKEIGVEEAIDYLKSINAPFGKNDGRGMVISNIDTGTDYRHKAMRIDDDAKASMRFKKEDL

KGTDKNYWLSDKIPHAFNYYNGGKTTVEKYDDGRDYTDPHGMHIAGILAGNDTEQDIKNPNGIDGIAPNAQTFSYKMY

SDAGSGFAGDETMTHATEDSIKHNVDVVSVSSGFTGTGLVGEKYWQATRALRKAGIPMVVATCNYATSASSSSWDLVA

NNHLKMTDTGNVTRTAAHEDATAVASAKNQTVEFDKVNIGGESFKYRNIGATTDKSKTTTNEDGTKAPSKLKPVYIGK

GQDQGLIGLDLRGKIAVMDRIYTKDLKNAFKKAMDKGARAIMVVNTVNYYNRDNWTELPAMGYEADEGTKSQVFSI

SGDDGVKLWNMINPDKKTEVKRNNKEDTKDKLEQYYPIDMESFNSNKPNVGDEKEIDTKFAPDTDKELYKEDIIPAG

STSWGPRIDLLLKPDVSAPGKNIKSTLNVINGKSTYGYMSGTSMATPIVAASTVLIRPKLKEMLERPVLKNLKGDDKIDL

TSLTKIALQNTARPMMDATSWKEKSQYFASPRQQGAGLINVANALRNEVVATTKNTDSKGLVNSYGSISLICEIKGDKK

YFTIKLHNTSNRPLTTKVSASATTDSLTDRLKLDETYKDEKSPDGKQIVPEIHPEKVKGANITTEHDTFTIGANSSTDLN

AVINVGEAKNKNKFVESFIHPESVEAMEALNSSGKKINFQPSLSMPLMGTAGNWNHEPILDKWAWEEGSRSICTLGGYD

DDGKPKIPGTLNKGIGGEHGIDKFNPAGVIQNRKGKNTTSLDQNPELFAFNNEGINAPSSSGSKIANIYPLDSNGNPQDA

QLERGLTPSPLVLRSAEEGLISIVNTNKEGENQRDLKVISREHFIRGILNSKSNDAKGTTTSSKLKVWGDLKWDGLIYNPRG

REENAPESKDNQDPATKIRGQTEPIAEGQYFYKFKYRLTKDYPWQVSYIPVKIDNTAPKIVSVDTSNPEKIKLITKDTYHK

VKDQYKNETLFARDQKEHPEKFGEIANEVWYAGAALVNEDGEVEKNLEVTYAGEGQGRNRKLDKDGNTIYEIKGAG

DLRCKIIEVIALDGSSNTKIHRKTANQADEKGMISYYLVDPDQDSSKYQKLGEJAESKTKNLGNGKEGSLKKDTTGVE

HHHQENEESIKEKSSFTIDRNISTIRDFENKDLKKLIKKKFREVDDFTSETGKRMEEYDYKYDDKGNIIAYDDGTLEYE

TEKLDEIKSKIYGVLSPSKDGHFEILGKISNVSKNAKVYYGNNYKSIEIKATKYDFHSKTMTFDLYANINDIVDGLAFAG

DMRLFVKDNDQKKAEIK1RMPEKIKETKSEYPYVSSYGNVIELGEGDLSKNKPDNLTKMESGKIYSDSEKQQYLLKDNII

LRKGYALICVTTYNPGKTDMLEGNGVYSKEDIAKJQKANPNLRALSETTTYADSRNVEDGRSTQSVLMSALDGTNIIRYQ

VFTFKMNDKGEATDKDGNLWSSKLVLTGKDDKEYTGEDKPNVEATKEDGSMLPIDTTTPVNLSMDKNYTNPSKSNKI

YVRNPETYLRGTCISDKGGFNWELRVNESVVGNYLIYGDLHIDNTRDFNIKLNVKDGDIMDWGMKDYKANGTPDKVTD

MDGNVYLQTGYSDLNAKAVGVHYQFLYDNVKPEVNIGPKGNTSIEYADGKSVVFNINDKRNNGPDGEIQEQHIYINGIC

EYTSPNDIKQIIDKTLNIKIVVKDFARNTTVKETTLNKDTGEVSELKPHRVTVTTQNGKEMSSTTVSSEDFILPVYKGELEK

GYQFDGWEISGFEGKKDAGYVINLSKDTFIKPVFKKIEEKKEEENKPThDVSKKKDNPQVNHSQLNESHRKEDLQREEH

SQKSDSTKDVTATVLDKNNISSKSTTNNPNKLPKTGTASGAQTLLAAGIMFIVGTTLGLKKKNQDZ

ID6 597 bp
CTTGAATTAAATAAAAAACGTCATGCGACTAAGCATTTTACTGATAAGCTTGTTGATCCCAAAGATGTGCGTACGG

CTATCGAAATTGCAACCTTAGCGCCAAGCGCCCACAACAGCCAGCCTTGGAAATTTGTGGTGGTACGTGAGAAAA

ATGCGAACTGGCAAAGTTAGCTTATGGTTCCAATTTTGAACAGGTATCATCAGCGCCTGTAACCATTGCCTTGTT

TACAGATACGGACTTAGCCAAACGTGCTCGTAAGATTGCCCGTGTTGGTGGTGCTAATAACTTTTCTGAAGAGCAA

CTTCAATATTTTATGAAAAATCTGCCAGCTGAGTTTGCCCGTTACAGTGAGCAACAAGTCAGCGACTACCTAGCTC

TCAATGCAGGTTGGTTGCCATGAACTTGGTTCTTGCATTGACAGACCAAGGAATTGGTTCTAACATTATTCTTGG

TTTTGACAAATCAAAAGTTAATGAAGTTTTGGAAATCGAAGACCGTTTCCGCCCAGAACTCTTGATCACAGTGGGT

TATACAGACGAAAAATTGGAACCAAGCTACCGCTTGCCAGTAGATGAAATCATCGAGAAAAGATAG

LELNKKRHATKHTTDKLVDPKDVRTATEIATLAPSAHNSQPWKFVVVREKNAELAKLAYGSNTEQVSSAPVTTALFTDT

DLAKRARKIARVGGANNFSEEQLQYTMKNLPAEFARYSEQQVSDYLALNAGLVAMNLVLALTDQGIGSNLILGFDKSK

VNEVLEIEDRFRPELLTTVGYTDEKLEPSYRLPVDEIIEKRZ

ID7 1401 bp
ATGACAGCAATTGATTTTACAGCAGAAGTAGAAAAACGCAAAGAAGACCTCTTGGCTGACTTGTTTAGCCTTTTG

GAAATCAATTCAGAACGTGATGACAGCAAGGCTGATGCCCAGCATCCATTTGGGCCTGGTCCAGTAAAAGCCTTG

GAGAAATTCCTTGAAATCGCAGACCGCGATGGCTACCCAACTAAGAATGTTGATAACTATGCAGGACATTTTGAG

TTTGGTGATGGAGAAGAAGTTCTCGGAATCTTTGCCCATATGGATGTGGTGCCTGCTGGTAGCGGTGGGACACAG

ACCCTTACACACCAACTATCAAAGATGGTCGCCTTTATGCGCGCGGGGCTTCGGACGATAAGGGTCCTACAACAG

CTTGTTACTATGGTTTGAAAATCATCAAAGAATTGGGTCTTCCAACTTCTAAGAAAGTTCGCTTCATCGTTGGAAC

AGACGAAGAATCAGGCTGGGCAGACATGGACTACTACTTTGAGCACGTAGGACTTTGCCAAACCAGATTTCGGTTT

CTCACCAGATGCTGAATTTCCAATCATCAATGGTGAAAAAGGAAATATCACGGAATACCTCCACTTTGCAGGAGA

AAATACAGGTGTTGCCCGTCTTCACAGCTTTACAGGTGGTTTACGTGAAAATATGGTACCAGAATCAGCAACAGC

AGTCGTTTCAGGTGACTTGGCTGACTTGCAAGCTAAACTAGATGCCTTTGTTGCAGAACACAAACTTAGAGGAGA

ACTCCAAGAAGAAGCTGGCAAATACAAGGTGACGATCATTGGTAAATCAGCCCACGGTGCTATGCCTGCTTCAGG

TGTCAATGGCGCAACTACCTTGCCCTCTTCCTCAGCCAGTTTGGCTTTGCTGGTCCAGCCAAAGACTACCTTGAC

ATCGCAGGTAAAATTCTCTTGAACGATCATGAGGGTGAAAATCTTAAGATTGCTCATGTGGATGAAAAGATGGGT

GCTCTTTCTATGAATGCCGGCGTCTTCCACTTCGATGAAACAAGTGCTGATAATACCATTGCCCTCAACATCCGCT

ATCCAAAAGGAACAAGTCCAGAACAAATCAAGTCAATCCTGAAAACTTGCCAGTTGTTTCTGTTAGCCTGTCTGA

ACACGGTCACACGCCTCACTATGTGCCAATGGAAGATCCACTGTGCAAACCTTGTTGAATATCTATGAAAAACA

AACTGGCTTTAAAGGTCATGAACAAGTCATCGGTGGTGGAACCTTTGGTCGCTTGCTAGAACGCGGAGTTGCCTA

CGGTGCTATGTTCCCAGACTCGATTGATACCATGCACCAAGCCAATGANTTTKTCGCCTTGGATGATCTTTTCCGA

GCAGCAGCAATTTATGCCGAAGCTATTTACGAATTGATCAAATAA

MTAIDTAEVEKRKEDLLADLTSLLEINSERDDSKADAQHPTGPGPVKALEKTLEIADRDGYPTKNVDNYAGHTEIGD

GEEVLGIFAHMDVVPAGSGWDTDPYTTTKDGRLYARGASDDKGPTTACYYGLKIIKELGLPTSKKVRFIVGTDEESGW

ADMDYYFEHVGLAKPDFGTSPDAEFPIINGEKGNTTBYLHFAGENTGVARLHSFTGGLRENMVPESATAVVSGDLADL

QAKLDAFVAEHKLRGELQEEAGTCYKVTTTGKSAHGAMPASGVNGATYLALFLSQTGFAGPAKDYLDIAGKILLNDHEG

ENLKIAHVDEKMGALSMNAGVFHFDETSADNTTALNIRYPKGTSPEQIKSILENLPVVSVSLSEHGHTPHYVPMWPLVQ

TLLNIYEKQTGFKGHEQVIGGGTFGRLLERGVAYGAMTPDSIDTMHQANETTALDDLFRAAATYAEATYELIKZ

ID8 1617 bp
GTGTATACTATTATAAAATCAAATATAAAAAAATTTAGTTTATTAACGATATTTATTGTTGCTGGTCAATTATTGCT

AATTTATGCAGCAACTATTAATGCTCTGGTGTTGAATGAATTAATTGCGATGAATTTAGAGCGGTTTTTGAAATTG

TCAATCTACCAAATGATTGTCTGGTGTGGGATAATATTCCTTGACTGGGTAGTGAAAAATTATCAGGTTGAAGTGA

TCCAAGAGTTTAATCTAGAGATTCGAAATAGAGTTGCCACAGACATCTCTAACTCTACCTATCAAGAATTTCATAG

TAAATCATCAGGAACATATCTTTCGTGGCTAAATAATGATGTTCAGACTTTAAATGATCAGGCGTTTAAACAACTT

TTTTAGTAATAAAAGGAATTTCTGGTACTATATTTGCAGTTGTGACTCTTAATCACTATCATTGGTCKTTGACTGT

AGCCACCTTGTTTTCATTAATGATTATGCTACTTGTACCAAAAATCTTTGCATCGAAAATGCGAGAAGTTAGTCTA

AATTTAACTAACCAAAATGAAGCTTTTTTAAAATCTAGTGAGACTATATTGAATGGATTTGATGTGTTAGCGTCCT

TGAATCTTTTATATGTATTGCCTAAGAAAATTAAAGAAGCAGGAATTTTATTAAAGATGGTTATACAAAGAAAGA

CAACTGTAGAAACGTTAGCAGGCGCTATTAGCTTCTTTCTCAATATTTTTTTTCAGATATCTCTCGTTTTTTTAAT

GGCTATCTTTGCAATAAAAGGAATAGTGAAAATTGGTACTATTGAAGCAATAGGAGCACTAACAGGTGTTATTTTT

ACAGCGCTAGGTGAATTAGGAGGTCAATTATCCTCTATTATTGGTACGAAGCCTATTTTTTTAAAATTGTATTCAA

TTAATCCAATTGAGTCAAATAAAATGAATGATATCGAACCAAATGAGGTGAATAGAGATTTTCCGTTATATGAAG

CAAAAAATATTTGCTATAAGTATGGAGATAAAGAAATATTAAAAAACTTAAATTTTTGTTTTCAACGTAATGAAAA

GTATTTAATTTTAGGTGAAAGTGGAAGCGGGAAATCTACATTATTAAAATTATTGAATGGCTTTTTGAGAGATTAT

AGTGGAGAATTGCGATTCTGCGGGGATGATATAAAAAAAACCTCCTATTTAAATATGGTTTCGAATGTTCTATATG

TAGATCAAAAAGCTTATTTGTTTGAAGGTACGATTAGAGATAATATTTTATTGGAAGAAAATTATACTGATGAAGA

AATACTACAGTCTTTAGAGCAAGTTGGTTTGAGTGTAAAAGATTTTCCTAATAACATTTTAGATTATTATGTTGGT

GATGATGGGAGATTACTGTCAGGAGGGCAGAAACAAAAAATTACTTTAGCTAGAGGGCTAATTAGAAATAAGAA

AATAGTATTAATTGACGAGGGAACTTCTGCTATCGATAGGAGAACTCGTTAGCGATTGAACGTAAGATATTAGA

TAGAGAGGATTTGACTGTCATTATTGTTACCCATGCTCCGCATCCGGAACTTAAACAATATTTTACTAAGATATAT

CAATTTCCAAAGGATTTTATTTAA

MYTIIKSNLIKTSLLTTIVAGQLLLIYAATINALVLNELIAMNLERFLKTTYQMIVWCGTTTLDWVTNYQVEVIQEFNL

EIRNRVATDISNSTYQETHSKSSGTYLSWLNNDVQTLNDQAFKQLFLVIKGISGTIFAVVTLNHYHWSLTVATLTSLMIM

LLVPKIFASKMREVSLNLTNQNEAFLKSSETTLNGFDVLASLNLLYVLPiIKEAGILLKMVIQRKTTVETLAGAISFFLNI

FFQISLVFLTGYLAIKGIVKIGTIEIGALTGVIFTALGELGGQLSSIIGTKPIFLKLYSINPIESNKMNDIEPNEVNRDFPLYE

AKNICYKYGDKEILKNLNFCFQRNEKYLILGESGSGKSTLLKLLNGFLRDYSGELPTTCGDDIKKTSYLNMVSNVLYVDQ

KAYLTEGTTRDNILLEENYTDEEILQSLEQVGLSVKDTPNNILDYYVGDDGTLLSGGQKQKTTLARGLIPTKKIVLIDEGT

SAIDRRTSLAIERKILDRBDLTVIIVTHAPHPELKQYFTKIYQFPKDFIZ

ID9 705 bp
ATAACAGTTAAACAGATTATGGACGAAATAGCCGTTTCAGATATGACTGCAAGGCGATATTTACAGGAATTAGCT

GATAAAGATTTGCTGATTCGTGTGCATGGTGGAGCTGAAAAACTTCGAACCAACTCCCTTTTGACTAATGAGCGAT

CAAATATTGAAAAACAAGCCCTCCAAACGGCAGAAAAACAAGAAATAGCCCATTTTGCAGGCAGTCTAGTAGAA

GAAAGAGAAACTATTTTCATTGGACCAGGAACAACATTAGAGTTTTTTGCGCGTGAGTTGCCTATTGACAATATCC

GCGTCGTAACCAACAGTCTACCTGTTTTTCTGATTTTAAGCGAACGAAAATTAACAGATTTGATTTTAATAGGTGG

AAATTATCGCGATATTACAGGTGCTTTTGTTGGTACATTGACCCTACAAAATCTCTCTAATCTCCAATTTTCTAAA

GCTTTCGTTAGCTGTAATGGTATTCAAAACGGAGCTCTAGCTACTTTTAGCGAGGAAGAGGGAGAGGCTCAACGC

ATCGCTTTAAATAATTCTAATAAAAAATATTTACTCGCAGATCATAGCAAGTTCAATAAGTTTGATTTTTATACTTT

TTATAATGTATCAAATCTTGATACTATTGTTTCAGATTCTAAACTAAGTGATTCAATCCTTTTTAAGCTATCTAAAC

ACATTAAAGTCATCAAGCCTTAA

ITVKQIMDEIAVSDMTARRYLQELADKDLLIRVHGGAEKLRTNSLLTNETNIEKQALQTTKQEIAHFAGSLVEERETI

FIGPTTLEFFARELPIDNIRVVTNSLPVFLILSERKLTDLILIGGNYRDITGAFVGTLTLQNLSNLQFSKAFVSCNGIQNGA

LATFSEEEGEAQRIALNNSNKKYLLADHSKFNKFDFYTFYNVSNLDTIVSDSKLSDSILFKLSKHIKVIKPZ

ID10 483 bp
ATGACTGAGTTTTCGTTAGATCTTCTTCTAGAAGCCATTAAACTAGCTCGTTGGACCTACTACTATCACTTGAAAC

AGCTAGACAAAACAGATAAAGACCAAGAGCTTAAAACTGAAATTCAATCCATCTTTATCGAACACAAGGGAAATT

ATGCTTATCGCCGGGTTCATTTAGAACTAAGAAATCGTGGTTATCTGGTAAATCATAAAAGAGTTCAAGGCTTGaT

GAAAGTACTCAATTTACAAGCTAAAATGCGAAAGAAACGAAAATATTCTTCTCATAAAGGAGACGTTGTAAGAA

GGCAGAGAATCTCATTCAAGCCCAATTTGAAGGCTCTAAAACAATGGAAAAGTGCTACACAGATGTGACTGAATT

TGCCATTCCAGCAAGTACTCAAAAGCTTTACTTATCACCAGTTTTAGATGGCTTTAACAGCGAAATTATTGCTTTT

AATCTTTCTTGTTCGCCTAATTTAGAATAA

MTEFSLDLLLEAIKLARWTYYYHLKQLDKTDKQELKTEIQSIFIEHKGNYAYRRVHLELRNRGYLVNHKRVQGLMK

VLNLQAKMRKKRKYSSHKGDVGKKAENLIQAQFEGSKTMEKCYTDVTEFAIPASTQKLYLSPVDGFNSEIIAFNLSCS1

PNLEZ

ID14 1266 bp
CCAGGATTGGTACCGTTGCAAGTGGTGTGCCTTTCCTCCTAAAGGAAAATGGAGGAAAAATCAATCAATCAGCA

CATTCAGATATCAAAGTTGCTAAGGTATTGGTCAAGGATGAAGATGAAAAAAATCGCTTGCTTGCAGCAGGGAAT

GACTTTAACTTTGTAACCAATGTGGATGATATTTATCAGACCAGGATATTACTATCGTAGTGGAATTGATGGGGC

GTATTGAGCCTGCTAAAACCTTTATCACTCGTGCCTTGGAAGCTGGAAAACACGTTGTTACTGCTAACAAGGACCT

TTTAGCTGTCCATGGCGCAGAATTGCTAGAAATCGCTCAAGCTAACAAGGTAGCACTTTACTACGAAGCAGCAGT

TGCTGGTGGGATTCCAATTCTTCGTACTTTAGCAAATTCCTTGGCTTCTGATAAAATTACGCGCGTCTTGGAGTA

GTCAACGGAACTTCCAACTTCATGGTGACCAAGATGGTGGAAGAAGGCTGGTCTTACGATGATGCTCTTGCGGAA

GCACAACGTCTAGGATTTGCAGAAAGCGATCCGACGAATGACGTAGATGGGATTGATGCAGCCTACAAGATGGTT

ATTTTGAGCCAATTTGCCTTTGGCATGAAGATTGCCTTTGATGATGTAGCCCACAAGGGAATCCGCAATATTCAC

CAGAAGACGTAGCTGTAGCTCAAGAGCTTGGTTACGTAGTGAAATTGGTTGGTTCTATTGAGGAAACTTCTTCAGG

TATTGCTGCAGAAGTGACTCCAACCTTCCTACCTAAAGCGCACCCACTTGCTAGTGTGAATGGCGTAATGAACGCT

GTCTTTGTAGAATCTATCGGTATTGGTGAGTCTATGTACTACGGACCAGGTGCGGGTCAAAAACCAACTGCAACA

AGTGTTGTAGCTGATATTGTCCGTATCGTTCGTCGTTTGAATGATGGTACTATTGGCAAAGACTTCAACGAATATA

GCCGTGACTTGGTCTTGGCAAATCCTGAAGATGTCAAAGCAAACTACTATTTCTCAATCTTGGCTCTAGACTCAAA

AGGTCAGGTCTTGAAGTTGGCTGAAATCTTCAATGCTCAAGATATTTCCTTTAAGCAAATCCTTCAAGATGGCAAA

GAGGGTGACAAGGCGCGTGTCGTTATCATCACACACAAGATTTAATAAAGCCCAGCTTGAAAATGTCTCAGCTGAA

TTGAAGAAGGTTTCAGAATTCGACCTCTTGAATACCTTCAAGGTGCTAGGAGAATAA

PGFGTVASGVPFLLKENGGKINQSAMSDIICVAKVLVKDEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVELMGRIEP

AKTFITRALEAGKHVVTANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKTTRVLGVVNGTSNF

MVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVlLSQFAFGMKIAFDDVAHKGIRNITPEDVAVAQE

LGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLASVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVRRL

NDGTTGKDFNEYSRDLVLANPEDVKANYYFSILALDSKGQVLKLAETTNAQDISFKQILQDGKEGDKARVVITTMKINKA

QLENVSAELKKVSETDLLNTTKVLGEZ

ID16 1725 bp
ATGAAACACCTATTATCTTACTTCAAACCCTACATCAAGGAATCAATTTTAGCCCCCTTGTTCAAGCTGTTAGAAG

CTGTTTTTGAGCTCTTGGTTCCCATGGTGATTGCTGGGATTGTTGACCAATCTTTACCTCAGGGAGATCAAGGTCA

TCTCTGGATGCAGATTGGCCTGCTCCTTATCTTTGCAGTAKTTGGCGTTTTAGTGGCCTTGATAGCTCAATTTTACT

CAGCAAAGGCAGCAGTAGGTTCTGCTAAGGAATTGACAAACGATCTTTATCGTCATATTCTTTCCTTGCCCAAGGA

CAGCAGAGACCGTCTGACAACTTCTAGTTTGGTCACTCGCTTGACTTCGGATACCTACCAGATTCAGACTGGTATC

AATCAATTCCTGCGTCTCTTnTACGAGCGCCCATTATCGTTTTTGGTGCCATTTTTATGGCTTATCGAATCTCAGC

TGAGTTGACTTTCTGGTTCTAGTCTTGGTTGCCATTTTGACCATTGTCATTGTAGGGTTATCTCGATTGGTCAATC

CTTTCTACAGTAGTCTCAGAAAGAAAACGGACCAACTGGTTCAGGAAACGCGCCAGCAATTGCAAGGGATGCGGG

TTATTCGTGCTTTTGGTCAAGAAAAACGAGAGTTACAGATTTTTCAAACCCTTAACCAAGTTTATGCTAGATACA

AGAAAAGACAGGTTCTGGTCTAGTTTATTAACACCTCTGACCTATCTGATTGTCAATGGAACTCTTCTCGTTATT

ATCTGGCAAGGCTATATTTCAATTCAAGGAGGAGTGCTCAGTCAAGGTGCTCTCATTGCTCTTATCAATTACCTCT

TACAGATTTTGGTGGAATTGGTCAAGCTAGCCATGTTGATCAATTCCCTCAACCAGTCCTATATCTCAGTCAAGCG

AATCGAGGAAGTCTTTGTTGAGGCTCCAGAGGATATCCATTCAGAGTTAGAACAAAAGCAAGCTACCAGAGATAA

GGTTTTACAAGTCCAAGAATTGACCTTTACCTATCCTGATGCGGCCCAGCCTTCTCTGAGATACATTTCCTTTGAT

ATGACTCAAGGACAAATTCTAGGTATCATCGGGGGAACTGGTTCTGGTAAATCAAGCTTGGTGCAACTCTTACTTG

GACTTTATCCAGTAGACAAGGGGAACATTGACCTTTATCAAAATGGACGTAGTCCTCTTAATTTGGAGCAGTGGC

GGTCTTGGATTGCCTATGTACCTCAAAAGGTCGAACTCTTTAAAGGAACCATTCGTTCCAACTTGACTCTAGGTTT

CAATCAAGAAGTATCTGACCAGGAACTCTGGCAGGCCTTGGAGATTGCGCAAGCTAAGGATTTTGTCAGTGAAAA

GGAAGGACTCTGGATGCTCTAGTTGAGGCAGGGGGGCGAAATTTCTCAGGTGGACAAAAACAAAGATTGTCTAT

CGCCCGAGCAGTCTTGCGCCAGGCTCCGTTTCTCATCCTAGATGATGCAACCTCGGCACTGGATACCATTACAGAG

TCCAAGCTCTTGAAAGCTATTAGAGAAAATTTTCCAAACACGAGCTTAATTTTGATCTCTCAACGAACCTCAACTT

TACAGATGGCGGACCAGATTCTCCTCTTGGAAAAAGGTGAGTTGCTAGCTGTTGGCAAGCACGATGACTTGATGA

AATCCAGCCAAGTCTATTGTGAAATCAATGCATCCCAACATGGAAAGGAGGACTAG

MKHLLSYTKPYIESILAPLFKLLEAVFELLVPMTTAGIVDQSLPQGDQGHLWMQIGLLLIFAVIGVLVATIAQFYSAKA

AVGSAKELTNDLYRHILSLPKDSRDRLTTSSLVTRLTSDTYQIQTGINQTLRLFLRAPIIVTGATTMAYRISAELTWFLVL

VAILTIVIVGLSRLVNPFYSSLRKKTDQLVQETRQQLQGMRVIRAFGQEKRELQTTQTLNQVYARLQEKTGTWSSLLTPL

TYLIVNGTLLVIIWQGYISIQGGVLSQGALIALINYLLQILVELVKLAMLINSLNQSYISVKRIEEVTVEAPEDIHSELEQKQ

ATRDKVLQVQELTFTYPDAAQPSLRYISFDMTQGQILGIIGGTGSGKSSLVQLLLGLYPVDKGNIDLYQNGRSPLNLEQ

WRSWIAYVPQKVELTKGTTRSNLTLGTNQEVSDQELWQALE1AQAKDTVSEKEGLLDALVEAGGRNFSGGQKQRLSIA

RAVLRQAPTLILDDATSALDTTTESKLLKATRBNTPNTSLILISQRTSTLQMADQILLLEKGELLAVGKHDDLMKSSQVYC

EINASQHGKEDZ

ID18 1224 bp
ATGAAACGTTCTCTCGACTCAAGAGTCGATTACAGTTTGCTCTTGCCAGTATTTTTCTACTGGTCATCGGTGTGGT

GGCTATCTATATAGCCGTTAGTCATGATTATCCCAATAATATTCTTGCCCATTTTAGGGCAGCAGGTCGCTGGATT

GCCTTGGGGCTTGTGATTGGTTTTGTGGTCATGCTCTTTAATACAGAATTTCTTTGGAAGGTGACCCCCTTTCTATA

TATTTTAGGCTTGGGACTTATGATCTTGCCGATGTATTTTATAATCCAAGCTTAGTTGCATCAACGGGTGCCAAA

AACTGGGTATCAATAAATGGAATTACCCTATTCCAACCGTCAGAATTTATGAAGATATCCTATATCCTCATGTTGG

CTCGTGTCATTGTCCAATTTACAAAGAAACATAAGGAATGGAGACGCACGGTTCCGCTGGACTTTTTGTTAATTTT

CTGGATGATTCTCTTTACCATTCCAGTCCTAGTTCTTTTAGCACTTCAAAGTGACTTGGGGACGGCTTTGTTTTTG

TAGCCATTTTCTCAGGAATCTTTTATTATCAGGGGTTTCTTGGAAAATTATTATCCCAGTATTTGTGACTGCTGTA

ACAGGAGTTGCTGGTTTCTTAGCTATCTTTATTAGCAAGGACGGACGAGCTTTTCTTCACCAGATTGGAATGCCGA

CCTACCAAATTAATCGGATTTTGGCTTGGCTCAATCCCTTTGAGTTTGCCCAAACAACGACTTACCAGCAGGCTCA

AGGGCAGATTGCCATTGGGAGTGGTGGCTTATTTGGTCAGGGATTTAATGCTTCGAATCTGCTTATCCCAGTTCGA

GAGTCAGATATGATTTTTACGGTTATTGCAGAAGATTTTGGCTTTATTGGCTCTGTCCTGGTTATTGCCCTCTATCT

CATGTTGATTTACCGTATGTTGAAGATTACTCTTAAATCAAATAACCAGTTCTACACTTATATTTCCACAGGTTTGA

TTATGATGTTGCTCTTCCACATCTTTGAGAATATCGGTGCTGTGACTGGACTACTTCCTTTGACGGGGATTCCCTTG

CCTTTCATTTCGCAAGGGGGATCAGCTATTATCAGTAATCTGATTGGTGTTGGTTTGCTTTTATCGATGAGTTACCA

GACTAATCTAGCTGAAGAAAAGAGCGGAAAAGTCCCATTCAAACGGAAAAAGGTTGTATTAAAACAAATTAAATA

A

MKRSLDSRVDYSLLLPVTTLLVIGVVATYIAVSHDYPNNILPILGQQVAWIALGLTTGTVVMLTNTETLWKVTPTLYILGL

GLMILPIVFYNPSLVASTGAKNWVSINGITLFQPSEFMKISYILMLARVIVQFTKKHKEWRJTTVPLDTLLTTWMILTPVL

VLLALQSDLGTALVFVAIFSGIVLLSGVSWKIIIPVFVTAVTGVAGFLAIFISKDGRAFLHQIGMPTYQINRILAWLNPFEF

AQTTYQQAQGQIAIGSGGLFGQGFNASNLLIPVRESDMIFTVIAEDFGFIGSVLVIALYLMLIYRMLKITLKSNNQFYTY

ISTGLIMMLLFHIFENIGAVTGLLPLTGIPLPFISQGGSAIISNLIGVGLLISMSYQTNLAEEKSGKVPFKRKKVVLKQIKZ

ID22 987 bp
ATGGTGGCTAAGAAAAAAATCTTATTTTTTATGTGGTCTTTTTCTCTTGGAGGTGGTGCAGAGAAGATTCTATCAA

CCATTGTTTCAAATCTGGATCCAGAAAAGTATGATATTGATATTCTTGAAATGGAGCACTTTGACAAGGGATATGA

ATCTGTTCCAAAGCATGTACGCATTTTAAAATCCCTTCAAGATTATCGCCAAACCAGATGGTTACGAGCTTTTTTG

TGGAGAATGAGAATTTATTTTCCAAGACTGACTCGTCGTTTGCTTGTAAAAGATGATTATGATGTTAAGTTTCTT

TTACCATTATGAATCCACCACTGTTGTTCTCTAAAAGAAGAGAAGTCAAGAAGATATCTTGGATTCATGGAAGTAT

TGAAGAACTTCTTAAGGATAGCTCTAAAAGAGAATCACATAGAAGCCAGTTGGATGCTGCGAATACAATTGTAGG

GATTTCAAAAAAGACCAGCAATTCTATCAAGGAAGTTTATCCAGATTATACTTCTAAATTACAGACAATCTACAAT

GGATATGATTTTCAGACTATTCTAGAAAAATCTCAAGAGAAGATCGATATCGAGATTGCTCCTCAAAGTATCTGTA

CTATCGGACGGATTGAGGAAAATAAGGGTTCTGACCGTGTAGTGGAAGTGATACGATTATTACACCAAGAGGGAA

AAAACTATCATCTCTATTTTATCGGGGCTGGTGATATGGAAGAGGAATGAAAAAATTCGAGTCAAAGAGTATGGGA

TTGAGGACTATGTACATTTCCTTGGTTATCAAAAAAATCCTTATCAGTATCTATCTCAGACGAAAGTTCTTTTGTCT

ATGTCTAAACAAGAAGGTTTTCCTGGAGTGTATGTGGAGGCCTTGAGTCTGGGACTCCCTTTTATCTCTACGGACG

TTGGAGGGGCTGAGGAATTATCCCAAGAAGGACGATTTGGACAAATCATTGAGAGCAATCAAGAGGCAGCTCAG

GCGATTACTAATTACATGACTTCTGCCTCAAACTTTGATGTCGATGAGGCTAGCCAATTCATTCAACAATTTACAA

TTACAAAACAAATCGAACAAGTAGAAAAACTATTAGAGGAGTAG

MVAKKKILFFMWSFSLGGGAEKILSTIVSNLDPEKYDIDILEMEHFDKGYESVPKHVRILKSLQDYRQTRWLRAFLWRM

RIYFPRLTRRLLVKDDYDVEVSFTIMNPPLLFSKRREVKKISWIHGSIEELLKDSSKRESHRSQLDAAVTIVGISKKTSNSIK

EVYPDYTSKLQTTYNGYDTQTTLECSQEKIDIE1APQSTTTGREENKGSDRVVETTPTLHQEGKNYKLYTGAGDMEEEEL

KKRVKEYGIEDYVHFLGYQKNPYQYLSQTKVLLSMSKQEGFPGVYVEALSLGLPFISTDVGGAEELSQEGRFGIIESNQ

EAAQAITNYMTSASNFDVDEASQFIQQVTTTKQIEQVEKLLEEZ

ID23 1434 bp
ATGGAAACTGCATTAATTAGTGTGATTGTGCCAGTCTATAATGTGGCGCAGTACCTAGAAAAATCGATAGCTTCCA

TTCAGAAGCAGACCTATCAAAATCTGGAAATTATTCTTGTTGATGATGGTGCAACAGATGAAAGTGGTCGTTTGTG

TGATTCAATCGCTGAACAAGATGACAGGGTGTCAGTGCTTCATAAAAAGAACGAAGGATTGTCGCAAGCACGAAA

TGATGGGATGAAGCAGGCTCACGGGGATTATCTGATTTTTATTGACTCAGATGATTATATCCATCCAGAAATGATT

CAGAGCTTATATGAGCAATTAGTTCAAGAAGATGCGGATGTTTCGAGCTGTGGTGTCATGAATGTCTATGCTAATG

ATGAAAGCCCACAGTCAGCCAATCAGGATGACTATTTTGTCTGTGATTCTCAAACATTTCTAAAGGAATACCTCAT

AGGTGAAAAAATACCTGGGACGATTTGCAATAAGCTAATCAAGAGACAGATTGCAACTGCCCTATCCTTTCCTAA

GGGGTTGATTTACGAAGATGCCTATTACCATTTTGATTTAATCAAGTTGGCCAAGAAGTATGTGGTTAATACTAAA

CCCTATTATTACTATTTCCATAGAGGGGATAGTATTACGACCAAACCCTATGCAGAGAAGGATTTAGCCTATATTG

ATATCTACCAAAAGTTTTATAATGAAGTTGTGAAAAACTATCCTGACTTGAAAGAGGTCGCTTTTTTCAGATTGGC

CTATGCCCACTTCTTTATTCTGGATAAGATGTTGCTAGATGATCAGTATAAACAGTTTGAAGCCTATTCTCAGATT

CATCGTTTTTTAAAAGGCCATGCCTTTGCTATTTCTAGGAATCCAATTTTCCGTAAGGGGAGAAGAATTAGTGCTT

TGGCCCTATTCATAAATATTTCCTTATATCGATTCTTATTACTGAAAAATATTGAAAAATCTAAAAAATTACATTA

G

METALISVIVPVYNVAQYLEKSIASIQKQTYQNLEIILVDDGATDESGRLCDSIAEQDDRVSVLHKKNEGLSQARNDGM

KQAHGDYLIFIDSDDYIHPEMIQSLYEQLVQEDADVSSCGVMNVYANDESPQSANQDDYFVCDSQTFLKEYLIGEKIPG

TICNKLIKRQIATALSFPKGLIYEDAYYHFDLIKLAKKYVVNTKPYYYYFHRGDSITTKPYAEKDLAYIDIYQKTYNEVV

KNYPDLKEVAFFRLAYHFFILDKMLLDDQYKFEAYSQIHRFLKGHAFAISRNPIFRKGRRISALALFINISLYRFLLLK

NIEKSKKLHZ

ID24 735 bp
ATGAGAATCAAAGAGAAAACCAATAATATTAATGGAGGAATAAAAAATGTAAGTAAGCATTATGGTCATTCAATC

ATTCTCAAAGATATAAATTTTGCACTTAACAAGGGTGAAATTGTTGGTCTAGCAGGGAGAAATGGAGTTGGTAAG

AGTACGTTGATGAAAATTCTTGTTCAGAATAATCAACCGACTTCAGGTAATATTATAAGCAGTGATAATGTTGGGT

ATTTAATCGAAGAACCAAAATTATTTTTATCTAAAACAGGTTTAGAGAATTTAAAATATTTGTCAAATTTATATGG

TGTTGACTACAATCAAGAAAGATTTAGATGTTTGATCCAAGAGTTAGATTTGACTCAGTCTATTAATAAAAAAGTA

AAGACCTATTCTTTGGGTACAAAACAAAAATTAGCTTTGCTTCTAACTCTCGTTACGGAACCTGATATATTGATTT

TAGATGAACCGACTAATGGTTTAGATATTGAATCATCACAAATAGTTTTAGCGGTTCTAAAAAAATTAGCTTTACA

TAGATGAACCGACTAATGGTTTAGATATTGAATCATCACAAATAGTTTTAGCGGTTCTAAAAAAATTAGCTTTACA

TGAAAATGTGGGAATTTTAATATCGAGTCATAAATTAGAAGACATTGAAGAAATTTGTGAGAGAGTTCTTTTCTTG

GAGAACGGGCTTTTGACATTTCAAAAAGTAGGAAAAGATAGTCATAATTTCTTGTTTGAGATAGCTTTTTCATCAG

CTACAGATAGAGACATTTTCATTACCAAACAAGAATTGGGATATTGTTTAG

MRIKEKTNNINGGIKNVSKHYGHSIILKDINTALNKGEIVGLAGRNGVGKSTLMKILVQNNQPTSGNLISSDNVGYLIEEP

KLFLSKTGLENLKYLSNLYGVDYNQERTRCLIQELDLTQSINKKVKTYSLGTKQKLALLLTLVTTPDILILDEPTNGLDIE

SSQIVLAVLKKLALHENVGILISSHKLEDIEEICERVLFLENGLLTFQKVGKDSHNLFEIAFSSATDRDIFITKQEFWDIVZ

ID25 1704 bp
ATGACTGAATTAGATAAACGTCACCGCAGTAGCATTATGACAGCATGGTTAAATCACCTAACCGTGCTATGCTTC

GTGCGACTGGTATGACAGATAAGGACTTGAAACATCGATTGTGGGAGTGATTTCGACTTGGGCGGAAAATACAC

CATGTACATTCACTTGCATGATTTCGGGAAACTGGCTAAAGAAGGTGTCAAATCTGCAGGCGCTTGGCCTGTAC

AGTTTGGAACCATTACCGTAGCGGACGGGATCGCTATGGGAACGCCTGGTATGCGTTTCTCTCTAACATCTCGTGA

CATCATCGCGGACTCCATCGAGGCGGCTATGAGTGGTCACAACGTGGATGCCTTCGTCGCTATCGGTGGCTGTGA

CAAGAACATGCCTGGATCTATGATTGCTATTGCTAATATGGATATCCCAGCTATTTTCGCCTATGGTGGAACTAT

GCACCGGGAAATCTTGATGGTAAAGATATCGACTTGGTTTCTGTCTTGAAGGTATCGGAAAAATTGAACCACGGT

GACATGACAGCTGAGGACGTGAAACGTCTTGAATGTAATGCCTGCCCTGGCCCTGGTGGTTGTGGTGGTATGTAT

ACTGCTAATACCATGGCAACTGCTATCGAAGTTCTAGGGATGAGTTTGCCAGGGTCATCCTCTCACCCAGCTGAAT

CAGTGATAAGAAAGAAGATATCGAAGCAGCAGGACGTGCTGTTGTTAAGATGTTGGAACTTGGTCTCAAATCCAT

CAGATATCTTGACTCGTGAAGCCTTTGAAGATGCTATCACTGTAACGATGGCTCTCGGTGGTTCTACAAACGCCAC

TCTTCACTTGCTCGCCATTGCCCATGCCGCAAATGTTGACTTGTCACTTGAGGACTTCAATACGATTCAAGAACGT

GTGCCTCACTTGGCCGACTTGAAACCATCTGGTCAGTATGTCTTCCAAGACCTCTACGAAGTCGGTGGTGTCCCTG

CGGTTATGAAGTATTTGTTGGCAAATGGTTTCCTTCACGGAGATCGCATCACATGTACTGGTAAGACTGTAGCTGA

AAACTTGGCTGACTTTGCAGACTTGACTCCAGGCCAAAAAGTTATCATGCCACTTGAAAATCCAAAACGTGCGGA

TGGTCCGCTTATCATCTTGAACGGGAACCTTGCTCCTGACGGTGCAGTTGCCAAGGTATCAGGTGTTAAAGTGCT

CGTCACGTTGGGCCAGCTAAGGTCTTTGACTCAGAAGAAGATGCGATTCAGGCCGTTCTGACAGATGAAATCGTT

GATGGCGATGTAGTCGTTGTTCGTTTTGTTGGACCTAAAGGTGGTCCTGGTATGCCTGAGATGTATCACTTCTTC

AATGATTGTTGGTAAAGGTCAGGGAGATAAGGTGGCCCTCTTGACGGACGGACGTTTCTCTGGTGGTACTTATGGT

CTGGTTGTTGGACATATCGCTCCTGAAGCTCAGGATGGTGGACCAATTGCCTATCTCCGTACCGGCGATATCGTTA

CGGTTGACCAAGATACCAAAGAAATTTCTATGGCCGTATCCGAAGAAGAACTTGAAAAACGCAAGGCAGAAACA

ACCTTGCCACCACTTTACAGCCGTGGTGTCCTCGGTAAATATGCCCACATCGTATCATCTGTCACGCGGAGCCG

TGACAGACTTCTGGAATATGGACAAGTCAGGTAAAAAATAA

MTELDKRHRSSIYDSMVKPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHFGKLAKEGVKSAGAWPVQPG

TITVADGTAMGTPGMRTSLTSRIIADSIEAAMSGHNVDATVATGGCDKNMPGSMTIAIANMDIPATTAYGGTTAPGNLT

KDIDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIE

AAGRAVVKMLELGLKPSDILTREATEDATTVTMALGGSTNATLHLLATAHAANVDLSLEDRATTQERVPHLADLKPSGQ

YVPQDLYEVGGVPAVMKYLLANGTLHGDRTTCTGKTVAENLADTADLTPGQKVIMPLENPKRADGPLIILNGNLAPDG

AVAKVSGVKVRRNVGPAKVPDSEEDATQAVLTDEIVDGDVVVVILIWGPKGGPGMPEMLSLSSMIVGKGQGDKVALLT

DGRTSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKPKAETTLPPLYSRGVLGKYAHIVSS

ASRGAVTDTWNMDKSGKKZ

ID26 274 bp
ATGTTATAATAAAAATAAAGAATTTAAGGAGAAATACAATATGTCAATTTTTATTGGAGGAGCATGGCCATATGC

AAACGGTTCGTTACATATTGGTCACGCGGCAGCGCTTTACCGGGGGATATTCTTGCkALGATACTATCGTCAGAA

GGGAGAGGAAGTTTTATATGTTTCTGGAAGTGATTGTAATGGAACCCCTATTTCTATCAGAGCTAAAAAAGAAAA

TAAGTCTGTGAAAGAAATTGCTGATTTTTATCATAAGGANTTTAATCCA

CYNKKETKEKYNMSTTGGAWPYANGSLHIGHAAALLPGDILARYYRQKGEEVLYVSGSDCNGTPISIPTKJCENKSVK

ETADTYHKETNP

ID28 1065 bp
ATGACAACATTATTTTCAAAAATTAAAGAAGTAACAGAACTTGCTGCAGTCTCAGGTCATGTGCGCCTGTCCGT

GCTTATCTCGTGAAAAGTTGACACCGCATGTGGATGAAGTGGTGACAGATGGCTTGGGTGGTATTTTTGGTATT

AACATTCAGAAGCTGTGGATGCACCGCGCGTCTTGGTCGCTTCTCATATGGACGAAGTGGTTTATGGTCAGCGA

AATCAAGCCAGATGGTACCTTCCGTGTCGTAGAAATCGGCTGGCTGGAACCCCATGGTGGTTAGCAGCTCGTTT

CAAACTCTTGACTCGTGATGGTCATGAAATTCCTGTGATTTCAGGTTCTGTTCCTCCGCATTTGACTCGTGGAAAC

GGGGGACCAACCATGCCAGCCATTGCCGATATCGTTTTTGATGGTGGTTTTGCGGACAAGGCTGAGGCAGAAAGT

TTTGGCATCCGTCCTGGTGATACCATTGTACCAGATAGTTCTGCATTTTGACAGCCAATGAAAAAAATATCATCT

CAAAAGCTTGGGATAACCGCTACGGTGTCCTCATGGTAAGCGAGCTAGCTGAAGCTTTATCGGGTCAAAAACTCG

GCAATGAACTCTATCTGGGTTCTAACGTCCAAGAAGAAGTTGGTCTGCGTGGCGCTCATACCTCTACAACCAAGTT

TGACCCAGAAGTCTTCCTCGCAGTTGATTGCTCACCAGCAGGTGATGTCTACCGTGGTCAAGGCAAGATTGGAGA

TGGAACCTTGATTCGTTTCTATGATCCAGGTCACTTGCTCTCCCAGGGATGATGGATTTCCTTTTGACAACGGCT

GAAGAAGCTGGTATCAAGTACCAATACTACTGTGGTAAAGGCGGAACAGATGCAGGTGCAGCTCATCTGAAAAAT

GGTGGTGTCCCATCAACAACTATCGGTGTCTGCGCTCGTTATATCCATTCTCACCAAACCCTCTATGCAATGGATG

ACTTCCTAGAAGCGCAAGCTTTCTTACAAGCCVTGGTGAAGAAATTGGATCGTTCAACGGTTGATTTGATTAAACA

TATTAA

MTTLFSKIKEVELAAVSGHEAPVRAYLREKLTPHVDEVVTDGLGGIFGIHSHEAVDAPRVLVASHMDEVGTMVSEIKP

DGTFRVVEIGGWNPMVVSSQRFKLLTRDGHEIPVISGSVPPHLTRGKGGPTMPAIADIVFDGGFADKAEAESFGIRPGDT

IVPDSSATLTANEKNIISKAWDNRYGVLMVSELEALSGQKLGNELYLGSNVQEEVGLRGAHTSTTKYDPEVTLAVTTS

PAGDVYGGQGKIGDGTLIRTYDPGHLLLPGMKDTLLTTAEEAGIKYQYYCGKGGTDAGAAHLKNGGVPSTTTGVCARY

IHSHQTLYAMDDTLEAQARTQALVKKLDRSTVDLIKHYZ

ID31 1182 bp
ATGGAATTTTCTATGAAATCAGTCAAAGGACTACTCTTTATCATAGCTAGTTTTATCTTGACTCTTTTGACTTGGAT

GAACACTTCTCCCCAATTCATGATTCCAGGACTAGCTTTAACAAGCCTATCTCTGACTTTTATCCTAGCCACTCGT

CTCCCACTACTAGAAAGCTGGTTTCACAGTTTGGAGAAGGTCTACACCGTCCACAAATTCACAGCCTTTCTCTCAA

TCATCCTACTAATCTTTCATAACTTTAGTATGGGCGTTTGTGGGGCTCTCGCTTAGCTGCTCAGTTTGGCAATCTT

GCCATCTATATCTTTGCCAGCATCATCCTTGTCGCCTATTTAGGCAAATACATCCAATACGAAGCTTGGCGATGGA

TTCACCGCCTGGTTTACCTAGCCTATATTTTAGGACTCTTTCACATCTACATGATAATTGGGCAATCGWTCTTACA

TTTAATCTTCTAAGTTTTCTTGTTGGTAGCTATGCCCTTTTAGGCTTACTAGCTGGTTTTTATATCATTTTTCTATAT

CAAAAGATTTCCTTCCCCTATCTAGGGAAAATTACCCATCTCAAACGCTTAAATCACGATACTAGAGAAATTCAA

ATCCATCTTAGCAGACCTTTCAACTATCAATCAGGACAATTTGCCTTTCTAAAGATTTTCCAAGAAGGCTTTGAAA

GTGCTCCGCATCCCTTTTCTATCTCAGGAGGTCATGGTCAAACTCTTTCTTTACTGTTAAAACTTCAGGCGACCA

TACCAAGAATATCTATGATAATCTTCAAGCCGGCAGCAAAGTAACCCTAGACAGAGCTTACGGACACATGATCAT

AGAAGAAGGACGAGAAAATCAGGTTTGGATTGCTGGAGGTATTGGGATCACCCCCTTCATCTCTTACATCCGTGA

ACATCCTATTTTAGATAAACAGGTTCACTTCTACTATAGCTTCCGTGGAGATGAAAATGCAGTCTACCTAGATTTA

CTCCGTAACTATGCTCAGAAAAATCCTAATTTTGAACTCCATCTAATCGACAGTACGAAAGACGGCTATCTTAATT

TTGAACAAAAAGAAGTGCCCGAACATGCAACCGTCTATATGTGTGGTCCTATTTCTATGATGAAGGCACTTGCCA

AACAGATTAAGAAACAAAATCCAAAAACAGAGCATATTTAC

MEFSMKSVKGLLFIIASFILTLLTWMNTSPQTMIPGLALTSLSLTFILATRLPLLESWFHSLEKVYTVHKFTAFLSIILLIFH

NFSMGGLWGSRLAAQFGNLAIYTTASIILVAYLGKYIQYEAWRWIHRLYLAYILGLFHIYMIMGNRLLTFNLLSFLVGS

YALLGLLAGFYIIFLYQKISTPYLGKITHLKRLNHDTREIQIHLSRPFNYQSGQFAFLKIFQEGFESAPHPFSISGGHGQTLY

TTVKTSGDHTKNIYDNLQAGSKVTLDRAYGHMIIEEGRBNQVWIAGGIGTTPTTSYIREHPILDKQVHIYYSTRGDENAV

YLDLLRNYAQKNPNFELHLIDSTKDGYLNFEQKEVPEHATVYMCGPISMMKALAKQIKKQNPKTEHIY

ID32 900 bp
ATGACTTTTAAATCAGGCTTTGTAGCCATTTTAGGACGTCCCAATGTTGGGAAGTCAACCTTTTTAAATCACGTTA

TGGGGCAAAAGATTGCCATCATGAGTGACAAGGCGCAGACAACGCGCAATAAAATCATGGGAATTTACACGACTG

ATAAGGAGCAAATTGTCTTTATCGACACACCAGGGATTCACAAGCCTAAAACAGCTCTCGGAGATTTCATGGTTG

AGTCTGCCTACAGTACCCTTCGCGAAGTGGACACTGTTCTTTTCATGGTGCCTGCTGATGAAGCGCTGGTAAGGG

GGACGATATGATTATCGAGCGTCTCAAGGCTGCCAAGGTTCCGTGATTTTTGGTGGTGAATAAAATCGATAAGGTC

CATCCAGACCAGCTCTTGTCTCAGATTGATGACTTCCGTAATCAAATGGACTTTAAGGAAATTGTTCCAATCTCAG

CCCTCAGGGAAATAACGTGTCTCGTCTAGTGGATATTTTGAGTGAAAATCTGGATGAAGGTTTCCAATATTTCCC

GTCTGATCAAATCACAGACCATCCAGAACGTTTCTGGTTTCAGAAATGGTTCGCGAGAAAGTCTTGCACCTAACT

CGTGAAGAGATTCCGCATTCTGTAGCAGTAGTTGTTGACTCTATGAAACGAGACGAAGAGACAGACAAGGTTCAC

ATCCGTGCAACCATCATGGTCGAGCGCGATAGCCAAAAAGGGATTATCATCGGTAAAGGTGGCGCTATGCTTAAG

AAAATCGGTAGCATGGCCCGTCGTGATATCGAACTCATGCTAGGAGACAAGGTCTTCCTAGAAACCTGGGTCAAG

GTCAAGAAAAACTGGCGCGATAAAAAGCTAGATTTGGCTGACTTTGGCTATAATGAAATGAGAATATAA

MTFKSGFVAILGRPNVGKSTFLNHVMGQKIATMSDKAQTTRNKIMGIYTTDKEQIVFIDTPGIHPKTALGDFMVESAYS

TLREVDTVLFMVPADEARGKGDDMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVS

RLVDILSBNLDEGTQYTPSDQTTDHPERTLVSEMVREKVLHLTREEIPHSVAVVVDSMKRDEBTDKVHIRATTMVEPDSQ

KGIIIGKGGAMLKKIGSMARRDIELMLGDKVTLETWVKVKKNWRDKKLDLADTGYNERBYZ

ID33 855 bp
CTGCTTCTTGTTTTTACAGAAGGAGGACTTATGCCTGAATTACCTGAGGTTGAAACCGTTTGTCGTGGCTTAGAAA

AATTGATTATAGGAAAGAAGATTTCGAGTATAGAAATTCGCTACCCCAAGATGATTAAGACGGATTTGGAAGAGT

TTCAAAGGGAATTGCCTAGTCAGATTATCGAGTCAATGGGACGTCGTGGAAAATATTTGCTTTTTATCTGACAGA

CAAGGTCTTGATTTCCCATTTGCGGATGGAGGGCAAGTATTTTTACTATCCAGACCAAGGACCTGTCGCAAGCAT

GCCCATGTTTTCTTTCATTTTGAAGATGGTGGCACGCTTGTTTTATGAGGATGTTCGCTGTTTGGTCCATGGAAC

TCTTGGTGCCTGACCTAGACGTCTACTTTATflTCTAAAAAATTAGGTCCTGAACCAAGCGAACAAGACTTTGA

TTTACAGGTCTTTCAATCTGCCCTTGCCAAGTCCAAAAAGCCTATCAAATCCCATCTCCTAGACCAGACCTTGGTA

GCTGGACTTGGCAATATCTATGTGGATGAGGTTCTCTGGCGAGCTCAGGTTCATCCAGCTAGACCTTCCCAGACTT

TGACAGCAGAAGAAGCGACTGCCATTCATGACCAGACCATTGCTGTTTTGGGCCAGGCTGTTGAAAAAGGTGGCT

CCACCATTCGGACTTATACCAATGCCTTTGGGGAAGATGGAAGCATGCAGGACTTTCATCAGGTCTATGATAAGA

CTGGTCAAGAATGTGTACGCTGTGGTACCATCATTGAGAAAATTCAACTAGGCGGACGTGGAACCCACTTTTGTCC

AAACTGTCAAAGGAGGGACTGA

MLLVTTEGGLMPELPEVETVCRGLEKLLIGKKISSIEIRYPKMIKTDLEETQRBLPSQLIESMGRRGKYLLTYLTDKVLISHL

RMEGKYTYYPDQGPERKHAHVPTTTEDGGTLVYEDVRKTGTMELLVPDLLDVYTTSKKLGPBPSEQDTDLQVTQSALA

KSKKPLKSHLLDQTLVAGLGNIYVDEVLWRAQVHPARPSQTLTAEEATATHDQTTAVLGQAVEKGGSTTRTYTNATGED

GSMQDTHQVYDKTGQECVRCGTLIEICIQLGGRGTHTCPNCQRRDZ

ID34 633 bp
TGTCCAAACTGTCAAAGGAGGGACGATGGGAAAAATCATCGGAATCATGGGGGAATGCCGTTT

ACTGTGACAAKflTTCTAAGACAGCAAGGCTITTCAAGTAGTGGATGCCGACGCAGTCGTCCACCAACTACAGAAA

CCTGGTGGTCGTCTGTGAGGCTCTAGTACAGCACTGGGCAAGAAATCATTCTGAATACGGAGTCTCJ&TTC

GCCCTCTCCTAGCTAGTCTCATCTCAAATCCTGATGAACGAGAATGGTCTATAGCAATTCTGGGGAGATAT

CCGTGAGGAACTGGCTACTTGAGAGAACAGTTGGCTCAGACAGAAGAGATTCTCATGGATAnCCCaACT

TGAGCAGGACTACAGCGATTGGTTGCTGAGACTGGTTGGTCTATGTGGACCGAGATGCCCAAGTGGAACGC

TTTATGAAAAGGGACCAGTTGTCCAAAGATGAAGCTGAGTCTCGTCTGGCAGCCCAGTGGCCTTAGTJTJTG

AAAGATTTGGCCAGCCAGGTTGATAATAATGGCAATCAGAACCAGCTCTAATCAAGTGCATATCCnCTTG

AGGGAGGTAGGCAAGATGACAGAGATTAA

MSKLSTTEGLMGKflGTTGGIASGKSTVTNTLRQQGTQVVDADAVVNQLQKPGGRLTEALVQHTGQEllLENGELNRPLL

ASLTTSNPDEREWSKQIQGEIIREELATLRBQLAQTEEITTMDIPLLTEQDYSDWTAETWLVYVDRDAQVERLMKRDQLS

KDEAESRLAAQWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRDZ

ID35 1269 bp
TTGATAATAATGGCAATCAGAACCAGCTCTTAATCAAGTGCATATCCTCTTGAGGGAGGTAGGCJTGATGACA

GAGA7AACTGGAAGGATAATCTGCGCATTGCCTGGTGGTAATTCTGACAGGAGCCAGTATTGTTGTG

TACCTTTTATGCCCATCTTCGTGGAAAATCTAGGTGTAGGGAGTCAGCAAGTCGCtTTTTATGCAGGCTTAGCAAT

TTCTGTCTCTGCTATTCCGCGGCGCTGTTCTCCTATTGGGGTATCTTGCTGACAAATACGGCCGTJATCCCA

TGATGATTCGGCCAGGTCTGCTATGACTATCACTATGGGAGGCTGGCTGTCCCAT&ATATCTATTGGTTT

CTCTCGTTACTAAACGGTGTATTTGCAGGnTTGTTCCTAATGCAACGGCACTGATAGCCAGTCAGGnCCA

AAGGAGAAATCAGGCTCTGCCTAGGTACTGTCTACAGGCGTAGTTGCAGGTAATGGTCCTTTAITG

GTGGCTTTATCGCAGAATTATTTGGCMTCGTACAGTTTTTTCTTACTQGTTGGTAGTTTTCTATTTTTAGCTGCTATTT

TGACTATTTGCTTATCAAGGAAGATTCAACCAGTAGCCAAGCATAGGCTATTCCAACAAAGGTAflIAC

T

GCCCTNTTTTGGCTCTTATGTACGCGACTAGGGCAGACAGAGAATCTTCTTTTTGTCTCTGGTTTGATTGTGTCC

AGTATGGGCTTCCAGCATGATGAGTGCAGGAG7CATGGGCAAGCTAGGTGACAAGGTGGGCTJJCATCGTTC

TGGTTGTCGCCCAGTATTCAGTCATCATCTATCTCCTCTGTGCCAATGCCTCTAGCCCCTCTAGGAT

CTATCGTCCTCTGGKTTGGGAACCGGTGCCTTGATTCCCGGGGTTAATGCCCTACTCAGCAAAATGACTCCC

AAAGCCGGCATTTCGAGGGTCtITTGCCCAATCAGGTATTCTTATCTGGGAGGTGTTGYTGGTCCCATGQTQ

GTTCTGCAG7AGCAGGTCAAtYTGGCTACCATGCTGTCTTATGCGACAAGCTTTGTGTTGCAGTGTTC

TAACCTGATTCAATTCGAACATTATTAAAAGTAAAGGAAAWTAG

MIIMATRTSTLIKCTSTLRBVGTTMTEINWKDNLRIAWTGNTLTGASSLVVPTMPTTVENLGVGSQQVATYAGLATSVSAT

AALTSPIWGILADKYGRKPMMJRAGLAMTTTMGGLATVPNIYWLTTLRiLNGVTAGTVPNATALxASQVPKTSGSAiG

TLTGVVAGTLTGPTTGGRAELTGIRTVTLLVGSTLTLAATLTTCTTKEDTQPVAKEKATPTK2LTTSVKYPYLLLNLTLTS

TVIQTSAQSTGPILALYVRDLGQTENLLIVSGLIVSSMGTSSMMSAGVMGKLGDKVGNHRLLVVAQTYSVIIYLLCANAS

SPLQLGLYRTLTGLGTGALIPGVNALLSKMPKAGSRVTATNQVTTYLGGVVGPMAGSAVAGQTGYHAVTYATSLCV

ATSCLTNLIQTRTLLKVKEIZ

ID36 1311 bp
ATGGCCCTACCAACTATTGCCATTGTAGGACGTCCCAATGTTGGGAAATCAACCCTATTTTAATCGGATCGCTGGTG

AGCGAATCTCCATTGTAGAAGATGTCGAAGGAGTGACACGTGACCGTATTTATGCAACGGGTGAGTGTAYTC

GTTCTTTAGCATGATTGATACAGGAGGAATTGATGATGTCGATGCTCCTTTCATGGAACAAATCAAGCACCAGGC

AGAAKTTGCCATGGAAGAAGCAGATGTTATCGTTTTTGTCGTGTCTGGTAAGGAAGGAATTACTGATGCAGACGA

ATACGTAGCTCGTAAGCTATAAGACCCACAAACCAGTTATCCTCGCAGTCATCATGGTGGACTCCTGAGAT

GAGAAATGATATATATGKTTTCTATGCTCTCGGTTTGGGTGAACCATTGCCTATCTCATCTGTCCATGGAATCGG?

ACAGGGGATGTGCTAGATGCGATCGTAGAAAATCTTCCAAATGAATATGAGGAAGAAAATCCAGATGTCATMG

TAGCTTGATTGGTCGTCCTAACGTTGGAAAATCAAGGTGATCAATGCTATCTGGGAGAAGACCGTGflATJG

CTAGTCCTGTTGCTGGAACAACTCGTGATGCCATTGATACCCACTTTACAGATACAGATGGTCAAGAGTTTACCAT

GATTGATACGGCTGGTATGCGTAAGTCTGGTAAGGTTTATGAAAATACTGAGAAATACTCTGTTATGCGTGCCATG

CGTGCTATTGACCGTTCAGATGTGGTCTTGATGGTCATCAATGCGGAAGAAGGCATTCGTGAGTACGACAAGCGT

ATCGCAGGATTTGCCCATGAAGCTGGTAAAGGGATGATTATCGTGGTCAACAAGTGGGATACGCTTGAAAAAGAT

AACCACACTATGAAAAACTGGGAAGAAGATATCCGTGAGCAGTTCCAATACCTGCCTTACGCACCGATTATCTTT

GTATCAGCTTTAACCAAGCAACGTCTCCACAAACTTCCTGAGATGATTAAGCAAATCAGCGAAAGTCAAAATTACA

CGTATTCCATCAGCTGTCTTGAACGATGTCATCATGGATGCCATTGCCATCAACCCAACACCGACAGACAAAGGA

AAACGTCTCAAGATTTTCTATGCGACCCAAGTGGCAACCAAACCACCAACCTTTGTCATCTTTGTCAATGAAGAAG

AACTCATGCACTTTCTTACCTGCGTTTCTTGGAAAATCAAATCCGCAAGGCCTTTGTTTTTGAGGGAACACCGAT

TCATCTCATCGCAAGAAAACGCAAATAA

MALPTIAIVGRPNVGKSTLTNRIAGERISIVEDVEGVTRDRIYATGEWLNRSTSMIDTGGIDDVDAPTMEQIKHQAEIAM

EEADVIVTVVSGKEGTTDADEYVARKLYTZTHKPTTLAVNKVDNPEMRNDIYDTYALGLGEPLPISSVHGIGTGDVLDAT

VENLPNEYEEENPDVIKTSLIGRPNVGKSSLINATLGEDRVIASPVAGTTRDATDTHTTDTDGQETTMIDTAGMRKSGKV

YENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDKRIAGFAHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQ

TQYLPYAPITTVSALTKQRLHKLPEMIKQISESQNTRIPSAVLNDVIMDATATNVTDKGKRLKTTYATQVATKPPTTVTTV

NEEELMHFSYLRFLENQIRAFVTEGTPIHLIARKRKZ

ID37 714 bp
ATGACAGAAACCATTAAATTGATGAAGGCTCATACTTCAGTGCGCAGGTTTAAAGAGCAAGAAATCCCCAAGTA

GACTTAAATGAGATTTTGACAGCAGCCCAGATGGCATCATCTGGAAGAATTTCCAATCCTACTCTGTGATGTGG

TACGAAGTCAAGAGAAGAAAGATGCCTTGTATGAATTGGTACCTCAAGAAGCCTTCGCCAGTCTGCTGTTTCCT

TCTCTTTGTCGGAGATTTGAACCGAGCAGAAAAGGGAGCCCGACTTCATACCGACACCTTCCAACCCCAAGGTGT

GGAAGGTCTCTTTGATTAGTTCGGTCGATGCAGCTCTTGCTGGACAAAACGCCTTGTTGGCAGCTGAAAGCTTGGGC

TATGGTGGTGTGATTATCGGTTTGGTTCGATACAAGTCTGAAGAAGTGGCAGAGCTCATAACCTACCTGACTACA

CCTATTCTGTCTTTGGGATGGCACTGGGTGTGCCAAATCAACATCATGATATGAAACCGAGACTGCCACTAGAGA

ATGTTGTCTTTGAGGAAGAATACCAAGAACAGTCAACTGAGGCAATCCAAGCTTATGACCGTGTTCAGGCTGACT

ATGCTGGGGCGCGTGCGACCACAAGCTGGAGTCAGCGCCTAGCAGAACAGTTTGGTCAAGCTGAACCAAGCTCAA

CTAGAAAAAATCTTGAACAGAAGAAATATTATTGTAG

MTETIKLMKAHTSVRRFKEQEIPQVDLNEILTAAQMASSWKNFQSYSVIVVRSQEKKDALYELVPQEAIRQSAVFLLFV

GDLNRAEKGARLHTDTTQPQGVEGLLISSVDAALAGQNATLAAESLGYGGVIIGLVRYKSEEVAELTNLPDYTYSVTG

MALGVPNQHHDMKPRPLPLENVVFEEEYQEQSTEAIQAYDTVQADYAGARATTSWSQRLAEQFGQAEPSSTRKNLEQK

KLLZ

ID38 729 bp
ATGACAGAAATTAGACTAGAGCACGTCAGTTATGCCTATGGTCAGGAGAGGATTTTAGAGGATATCAACCTACAG

GTGACTTCAGCCGAAGTGGTTTCCATCCTAGGCCCAAGTGGTGYTGGAAAGACCACCCTCITTAATCTAATCGCTG

GGATTTTAGAAGTTCAGTCAGGGAGAATTGTCCTTGATGGTGAAGAAAATCCCAAGGGGCGCGTGAGTTATATGT

TGCAAAAGGATCTGCTCTTTGGAGCACAAGACGGTGCTGGAAATATCATTCTGCCCCTCTTGATTCAAAAGGTGG

ATAAGGCAGAAGCTATTTCCCGAGCGGATAAAATTCTTGCGACCTTCCAGCTGACAGCTGTAAGAGACAAGTATC

CTCATGAACTTAGCGGTGGGATGCGCCAGCGTGTAGCCTTACTCCGGACCTACCTTTTTGGGCACAAGCTCTTTCT

CTTAGATGAGGCCTTTAGCGCCTTGGATGAGATGACAAAGATGGAACTCCACGCTTTGGTATCTTGAGATCACAA

GCAGTTGCAGCTAACAACCCTGATCATCACGCATAGTATTGAGGAGGCCCTCAATCTCAGCGACCGTATCTATATC

TTGAAAAATCGCCCTGGGCAGATTGTTTCAGAAATTAAACTAGATTGGTCTGAAGATGAGGACAAGGAAGTCCAA

AAGATTGCCTACAAACGTCAAATTTTGGCGGAATTAGGCTTAGATAAGTAG

MTEIRLEHVSYAYGQERILEDINLQVTSGEVVSILGPSGVGKTTLFNLIAGILEVQSGRVLDGEENPKGRVSYMLQKDLL

LEHKTVLGNIILPLLIQKVDKAEMSRADKKLATTQLTAVRDKYPHELSGGMRQRVALLRTYLTGHKLRTTDEATSALDE

MTKMELHAWYLEiHKQLQLTTLITTHSIEEALNLSDRIYILKNRPGQIVSEIKLDWSEDEDKEVQKIAYKRQILAELGLDK

Z

ID39 2433 bp
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCTGGACATTTTGGAGCTCGTTATC

TAGAGTCGTGGCACTTGTTGATTGCCATGTCTAATCACAGTTATAGTGTAGCAGGGGCAACTTTAAATGATTATCC

GTATGAGATGGACCGTTTAGAAGAGGTGGCTTTGGAACTGACTGAAACGGACTATAGCCAGGATGAAACCTTTAC

GGAATTGCCGTTCTCCCGTCGTTTGCAGGTTCTTTTTGATGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCTAAG

GTACTAGGGACAGAGCACGTCCTCTATGCGATTTTGCATGATAGCAATGCCTTGGCGACTCGTATCTTGGAGAGG

GCTGGTTTTTCTTATGAAGACAAGAAAGATCAGGTCAAGATTGCTGCTCTTCGTCGAATTTTAGAAGAACGGGCA

GGCTGGACTCGTGAAGATCTCAAGGCTTTACGCCAACGCCATCGTACAGTAGCTGACAAGCAAAATTCTATGGCC

AATATGATGGGCATGCCGCAGACTCCTAGTGGTGGTCTCGAGGATTATACGCATGATTTGACAGAGCAAGCGCGT

TCTGGCAAGTTTAGAACCAGTCATCGGTCGGGACAAGGAAATCTCACGTATGATTCAAATCTTGAGCCGGAAGACT

AAGAACAACCCTGTCTTGGTTGGGGATGCTGGTGTCGGGAAAACAGCTCTTCCGCTTGGTCTTGCCCAGCGTTATG

CTAGTGGTGACGTGCCTGCGGAAATGGCTAAGATGCGCGTGTTAGAACTTGATTTGATGAATCTCGTTGCAGGGA

CACGCTTCCGTGGTGACTTTGAAGAACGCATGAATAATATCATCAAGGATATTGAAGAAGATGCCCAAGTCATCC

TCTATCGATGAACTCCACACCATCATGGGTTCTTGGTAGCGGGATTGATTCGACTCTGGATGCGGCCAATATCTT

GAAACCAGCCTTGCCGCGTGGAACTTTGAGAACGGTTGGTGCCACTACTCAGGAAGAATATCAAAAACATATCGA

AAAAGATGCGGCACITTCTCGTCGTVICGCTAAAGTGACGATTGAAGAACCAAGTGTGGCAGATAGTATGACTAT

TTTACAAGGTTTGAAGGCGACTTATGAGAAACATCACCGTGTACAAATCACAGATGAAGCGGTTTGAAACAGCGGT

TAAGATGGCTCATCGTTATTTAACCAGTCGTCACTTGCCAGACTCTGCTATCGATCTCTTGGATGAGGCGGCAGCA

ACAGTGCAAAATAAGGCAAAGCATGTAAAAGCAGACGATTCAGATTTGAGTCCAGCTGACAAGGCCCTGATGGAT

GGCAAGTGGAAACAGGCAGCCCAGCTAATCGCAAAAGAAGAGGAAGTACCTGTCTACAAAGACTTGGTGACAGA

GTCTGATATTTTGACCACCTTGAGTCGCTTGTCAGGAATCCCAGTTCAAAAACTGACTCAAACGGATGCTAAGTG

TATTTAAATCTTGAAGCAGAACTCCATAAACGGGTTATCGGTCAAGATCAAGCTGTTTCAAGCATTAGCCGTGCCA

TTCGCCGCAACCAGTCAGGGATTCGCAGTCATAAGCGTCCGATTGTTCCTTTATGTTCCTAGGGCCTACAGGTGT

CGGGAAAACTGAATTAGCCAAGGCTCTGGCAGAAGTTCTTTTTGACGACGAATCAGCCCTTATCCGCTTTGATATG

AGTGAGTATATGGAGAAATTTGCAGCTAGTCGTCTCAACGGAGCTCCTCCAGGCTATGTAGGATATGAAGAAGGT

GGGGAGTTGACAGAGAAGGTTCGCAATAAACCCTATTCCGTTCTCCTCTTTGATGAGGTAGAGAAGGCCCACCCA

GATATCTTTAATGTTCTVTTGCAGGTTCTGGATGACGGTGTCTTGACAGATAGCAAGGGACGCAAGGTCGATTTTT

CAAATACCATTATCATTATGACATCGAATCTAGGTGCGACTGCCCTTCGTGATGATAAGACTGTTGGTTTTGGGGC

TAAGGATATTCGTTTTGACCAGGAAAATATGGAAAAACGCATCTTTTGAAGAACTGAAAAAAGCTTATAGACCGGA

ATCATCAACCGTATTTGATGAGAAGGTGGTCTTCCATAGCCTATCTAGTGATCATATGCAGGAAGTGGTGAAGATT

ATGGTCAAGCCTTTAGTGGCAAGTTTGACTGAAAAAGGCATTGACTTGAAATTACAAGCTTCAGCTCTGAAATTGT

TAGCAAATCAAGGATATGACCCAGAGATGGGAGCTCGCCCACTTCGCAGAACCCTGCAAACAGAAGTGGAGGAC

AAGTTGGCAGAACTTCTTCTCAAGGGAGATTTAGTGGCAGGCAGCACACTTAAGKTTGGTGTCAAAGCAGGCCAG

TTAAAATTTGATATTGCATAA

MNYSKALNECIESAYMVAGHTGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTE

LPTSRRLQVLFDEAEYVASVVHAKVLGTEHVLYATLEDSNALATRILERAGTSYEDKKDQVKIAALRRNLEERAGWTR

EDLKALRQRERTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLV

GDAGVGKTALALGLAQRLIASGDVPAEMAKMRVLELDLMNVVAGTRTRGDTEERMNNHKDIEEDGQVILRDELHTTM

GSGSGIDSTLDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRV

QITDEAVETAVKMAHRYLTSRHLPDSATDLLDEAAATVQNICAKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEV

PVKDLVTESDILTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSlSRATRRNQSGIRSHKRPIGSTMFLGP

TGVGKTELAKALAEVLTDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLTDEVEKAHP

DIFNVLLQVLDDGVLTDSKGRKVDTSNTTIIMTSNLGATALRDDKTVGFGAKDIRTDQENMBKRMTEELICKAYRPEFIN

RIDEKVVFHSLSSDHMQEVVKIMVKPLVASLTEKGIDLTLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELL

LKGDLVAGSTLKIGVKAGQLICTDEAZ

ID40 1008 bp
ATGAAGAAAACATGGAAAGTGTTTTTAACGCTTGTAACAGCTCTTGTAGCTGTTGTGCTTGTGGCCTGTGGTCAAG

GAACTGCTTCTAAAGACAACAAAGAGGCAGAACTTAAGAAGGTTGACTTTATCCTAGACTGGACACCAAATACCA

ACCACACAGGGCTTTATGTTGCCAAGGAAAAAGGTTATTCAAAGAAGCTGGAGTGGATTTTTGATTTGAAATTGC

CACCAGAAGAAAGTTCTTCTGACTGGTTATCAACGGAAAGGCACCATTTGCAGTGTATTTCCAAGACTACATGGC

TAAGAAATTGGAAAAAGGAGCAGGAATCACTGCCGTTGCAGCTATTGTTGAACACAATACATCAGGAATCATCTC

TCGTAAATCTGATAATGTAAGCAGTCCAAAAGACTTGGTTGGTAAGAAATATGGGACATGGAATGACCCAACTGA

ACTTGCTATGTTGAAAACCTTGGTAGAATCTCAAGGTGGAGACTTTGAGAAGGTTGAAAAAGTACCAAATAACGA

CTCAAACTCAATCACACCGATTGCCAATGGCGTCTTTGATACTGCTGGKTTTACTACGGTTGGGATGGTATCCTT

GCTAAATCTCAAGGTGTAGATGCTAACTTCATGTACTTGAAAGACTATGTCAAGGAGTTTGACTACTATCACCAG

TTATCATCGCAAACAACGACTATCTGAAAGATAACAAAGAAGAAGCTCGCAAAGTCATCCAAGCCATCAAAAAA

GGCTACCAATATGCCATGGAACATCCAGAAGAAGCTGCAGATATYCTCATCAAGAATGCACCTGAATTCAAGGAA

AAACGTGACTTTGTCATCGAATCTCAAAAATACTTGTCAAAAGAATACGCAAGCGACAAGGAAAAATGGGGTCAA

TTTGACGCAGCTCGCTGGAATGCTTTCTACAAATGGGATAAAGAAAATGGTATCCTTAAAGAAGACTTGACAGAC

AAAGGCTTCACCAACGAATTTGTGAAATAA

MKKTWKVFLTLVTALVAVVLVACGQGTASKDNKEAELKKVDFILDWTPNTNHTGLYVAKEKGYFKEAGVDVDLKLP

PEESSSDLVINGKAPFAVYGQDYMAKKLEKGAGITAVAAIVEHNTSGIISRKSDNVSSPKDLVGKKYGTWNDPTELAML

KTLVESQGGDTEKVEKVPNNDSNSTTPIANGVTDTAWIYYGWDGILAKSQGVDANTMYLKDYVKBTDYYSPVIIANND

YLKDNKEEARKVIQAIKKGYQYAMEHPEEAADILIKNAPELKEKRDFVIESQKYLSKEYASDKSKWGQPDTRWNAPY

KWDKENGTLKEDLTDKGTTNETVKZ

ID41 762 bp
TTGATGAGAAACTTGAGAAGTATACTGAGACGACACATTAGTCTATTGGGCTTTCTCGGAGTATTGTCAATCTGGC

AGTTAGCAGGTTTTCTTAAACTTCTCCCCAAGTTTATCCTGCCGACACCTCTTGAAATTCTCCAGCCCTTTGTTCGT

GACAGAGAATTTCTCTGGCACCATAGCTGGGCGACCTTGAGAGTGGCTTTACTGGGGCTGATTTTGGGAGTTTTGA

TTGCCTGTCTTATGGCTGTGCTCATGGATAGTTTGACTTGGCTCAATGACCTGATTTACCCTATGATGGTGGTCATT

CAGACCATTCCGACCATTGCCATAGCTCCTATCCTGGTCTTGTGGCTAGGTTATGGGATTTTGCCCAAGATTGTCT

TGATTATCTTAACGACAACCTTTCCCATCATCGTTAGTATTTTGGACGGTTTTAGGCATTGCGACAAGGATATGCT

GACCTTGTTTAGTCTGATGCGGGCCAAGCCTTGGCAAATCCTGTGGCATTTTAAAATCCCAGTTAGCCTGCCTTAC

TTTTATGCAGGTCTGAGGGTCAGTGTCTCCTACGCCTTTATCACAACTGTGGTATCTGAGTGGTTGGGAGGTTTTG

AAGGTCTTGGTGTTTATATGATTCAGTCTAAAAAACTGTTTCAGTATGATACCATGTTTGCCATTATTATTCTGGTG

TCGATTATCAGTCTTTTGGGTATGAAGCTGGTCGATATCAGTGAAAAATATGTGATTAAATGGAAACGTTCGTAG

MMRNLRSILRRHISLLGFLGVLSIWQLAGFLKLLPKFILPTPLEILQPFVRDREFLWHHSWATLRVALLGLILGVLIACLM

AVLMDSLTWLNDLIYPMMVVIQTIPTIAIAPILVLWLGYGILPKIVIILTTTFPIIVSILDGFRHCDKDMLTLFSLMRAKP

WQILWHFKIPVSLPYFYAGLRVSVSYAFITTVVSEWLGGFEGLGVYMIQSKKLFQYDTMTATTTLVSIISLLGMKLVDISE

KYVIKWKRSZ

ID42 372 bp
TTGATTTTTAATCCTATTTGCTGTATGATAAGGGAAAAGAAAGGGGACAGAGATATGGCTTTTACCAATACCCACA

TGCGATCTGCTAGTTTTGGTATTGTTACCAGCTTGCCTGATGACATCATTGACTCTTTTTGGTATATCATCGACCAT

TTCTTAAAAAATGTCTTTGAATTGGAAGAAGAACTCGAGTTTCAATTGCTTAATAACCAAGGAAAGATTACCTTCC

ACTTTTCAAGTCAACACCTCCCTACAGCCATTGATTTTGACTTTAACCATCCTTTCGACCCTCGTTATCCCCCAAGA

GTACTGGTTTTAGACATGGACGGTAGAGAAACTATCCTCCTCCCAGAAGAAAATGACCTATTTTAA

MIFNPICCMIREKKGDRDMAFNTHMRSASFGIVTSLPDDIIDSFWYIIDHFLKFELEEELEFQLLNNQGKTTTHFSSQ

HLPTAIDFDFNHPFDPRYPPRVLVLDMDGRETILLPEENDLT

ID43 1569 bp
ACAGCGGTGTCATTCTATCTATTTTAAGAAAAGTAATAATCAATTGTTAAAAATAGTAAAAAAATTGGAGGTTCTG

ATGAAATATTTTGTTCCTAATGAGGTATTCAGTATTCGTAAATTAAAGGTGGGGACTTGCTCGGTACTATTGGCAA

TTTCAATTTTGGGAAGCCAAGGTATTTTATCGGATGAAGTTGTTACTAGTTCTTCACCGATGGCTACAAAAGAGTC

TTCTAATGCAATTACTAATGATTTAGATAATTCACCAACTGTTAATCAGAATCGTTCTGCTGAAATGATTGCCTCT

AATTCAACCACTAATGGTTTAGATAATTCGTTAAGTGTTAATAGCATCAGCTCTAATGGTACTATTCGTTCCAATT

CACAATTAGACAACAGAACAGTTGAATCTACAGTAACATCTACTAATGAAAATAAGAGTTATAAGGAAGATGTTA

TAAGTGACAGAATTATCAAAAAAGAATTTGAAGATACTGCTTTAAGTGTAAAAGATTATGGTGCAGTAGGTGATG

GGATTCATGATGATCGACAAGCAATTCAAGATGCAATAGATGCTGCAGCTCAAGGGCTAGGTGGAGGAAATGTAT

ATTTTCCTGAAGGAACTTATTTAGTAAAAGAAATTGTTTTTTTAAAAAGTCATACACACTTAGAATTGAATGAGAA

AGCTACAATTCTAAATGGTATAAATATTAAGAATCACCCTTCCATTGTTTTTATGACAGGTTTATTTACGGATGAT

GGTGCGCAAGTAGAATGGGGCCCAACAGAAGATATTAGTTATTCTGGTGGTACGATTGATATGAACGGTGCTTTG

AATGAAGAAGGAACTAAAGCAAAAAAATCTACCACTTATAAATTCTTCAGGTGCATTTGCTATTGGGAATTCAAAT

AACGTAACTATAAAAAATGTAACATTCAAGGATAGTTATCAAGGGCATGCTATTCAAATTGCAGGTTCGAAAAAT

GTATTAGTTGATAATTCTCGTTTTCTTGGGCAAGCCTTACCCAAAACGATGAAGGATGGGCAAATCATAAGTAAGG

AGAGCATTCAGATTGAACCATTAACTAGAAAAGGTTTTCCTTATGCCTTGAATGATGATGGGAAAAAATCTGAAA

ATGTGACTATTCAAAATTCCTATTTTGGCAAAAGTGATAAATCTGGGGAATTAGTAACAGCAATTGGCACACACTA

TCAAACATTGTCGACACAGAACCCCTCTAATATTAAAATTCAAAATAATCATTTTGATAACATGATGTATGCAGGT

GTACGTTTTACAGGATTCACTGATGTATTAATCAAAGGAAATCGCTTTGATAAGAAAGTTAAAGGAGAGAGTGTA

CATTATCGAGAAAGCGGAGCAGCTTTAGTAAATGCTTATAGCTATAAAAACACTAAAGACCTATTAGATTTAAAT

AAACAGGTGGTTATCGCCGAAAATATATTTAATATTGCCGATCCTAAAACAAAAGCGATACGAGTTGCAAAAGAT

AGTGCAGAATGTTTAGGAAAAGTATCAGATATTACTGTAACAAAAAATGTAATTAATAATAATTCTAAGGAAACA

CAACAACCAAATATTGAATTATTACGAGTTAGTGATAATTTAGTAGTCTCAGAGAATAGT

QRCHSIYFKKSNNQLLKIVKKLEVLMKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITN

DLDNSPTVNQNRSAEMIASNSTTNGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVTSTNENKSYKEDVISDRIIKKEFEDT

ALSVKDYGAVGDGIHDDRQAIQDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVF

MTGLLFTDDGAQVEWGPTEDISYSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIA

GSKNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHY

QTLSTQNPSNIKIQNNHFDNMMYAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQ

VVIAENTTNIADPKTKATRVAKDSAECLGKVSDTTVTKNVINNNSKETEQPNIELLRVSDNLVVSENS

ID44 324 bp
GTGATGAAAGAAACTCAGCTATTAAAAGGTGTTCTTGAAGGTTGTGTCTTGGATATGATTGGTCAAAAAGAGCGG

TATGGTTATGAGTTGGTTCAGACTTTGCGAGAGGCTGGATTTGATACTATCGTTCCAGGAACTATTTATCCTTTGTT

GCAAAAGTTAGAAAAAAATCAATGGATAAGAGGCGACATGCGCCCGTCGCCAGATGGTCCAGATCGGAAGTATTT

TTCATTAATGAAAGAAGGAGAAGAGCGTGTCTCATCTTTTGGCAACAATGGGACGATTTGAGTCAAAAAGTAGA

AGGGATTAAGAATGGGGGTTAA

MMKETQLLKGVLEGCVLDMIGQKERYGYELVQTLREAGFDTIVPGTIYPLLQKLEKNQWIRGDMRPSPDGPDRKYFSL

MKEGEERVSVTWQQWDDLSQKVEGIKNGGZ

D45 816 bp
ATGAAGAAAATGAAGTATTACGAAGAAACAAGCGCTTTGCTACATGAGTTTTCTGAGGAGAATCAAAAGTATTTT

GAGGAGTTGTGGGAAAGTTTTAATCTTGCTGGMTTCTCTATGATGAAGACTATCTCAGAGAGCAGATCTATTTGA

TGATGCTAGATTTCTCAGAAGCAGAACGAGATGGCATGAGTGCAGAGGATTATCTAGGTAAGAATCCTAAAAAAA

TAATGAAAGAGATTCTCAAGGGAGCACCTCGCAGTTCTATCAAAGAGTCCCTTTTGACGCCAATTCTTGTCCTGGC

GGTATTACGTTATTATCAACTACTAAGTGTTTTTCTAAAGGTCCTCTCTTAACAGTCAATTTGCTCACATTTTTAG

GGCAACTCTTATTTTTCTGATTGGATTTGGACTTGTGGCCACAATTTTACGAAGAAGTTTAGTCCAAGATTCTCCT

AAAATGAAAATTGGCACTTACATTGTTGTTGGGACTATAGTTCTTCTAGTTGTTTTAGGATATGTAGGAATGGCAA

GCTTCATACAAGAAGGAGCCTTTTATATTCCGGCTCCCTGGGATAGTTTGTCTGTCTTTACGATTTCGCTAGTTATC

GGTATTGGAATTGGAAAGAAGCGGTCTTTCGTCCATTTGTCAGTATGATTATTGCCCATCTTGTGGTGGGTTCTCT

GCTCCGTTATTATGAGTGGATGGGAATTTCAAATGTTTTCCTTACAAAAGTTATTCCTTTAGCTGTCCTCTTTATTG

GAATCTTTGTCTTGTTCCGTGGGTTTAAGAAGATAAAATGGAGTGAAGTATAG

MKKMKYYEETSALLHEFSEENQKYFEELWESFNLAGFLYDEDYLREQIYLMMLDFSEAERDGMSAEDYLGKNPKKIM

KEILKGAPSSISLLTPILVLAVLRYYQLTDTSKGPLLTVNLLTPLGQLLTTLIGTGLVATTLRRSLVQDSPKMTTGTYI

VVGTIVLLVVLGYVGMASFIQEGAFYIPAPWDSLSVFTISLVIGIWNWKEAVFRPFVSMIIAHLVVGSLLRYYEWMGISN

VTLTKVIPLAVLTTGTTVLTRGTKKIKWSEVZ

ID46 348 bp
CTGTTTTTTTATTTATACTCAATGAAAATCAAAGAGCAAACTAGGAAGCTAGCCGCAGGTTGCTCAAAACACTGTT

TTGAGGTTGTAGACGAAACTGACGAAGTCAGCTCAAAACATGTVTTTGAGGTTGTAGATGATACTGACGAAGTCA

GCTCAAAACACTGTTTTGAGGTTGTAGAATGAAAGTCACGAAGTCAGCTCAAAACAGTCTTTTGAGTTGTAGATG

AAACTGACGAAGTCAGCTCAAAACATGTTTTTGAGGTTGTAGATGAAACTGACGAAGTCAGTAACCATACATACG

GTAGGGCGACGCTGACGTGTTTGAAGAGATTCGAAGAGTATTAA

MTTYLYSMKIKEQTRKLAAGCSKHCTEVVDETDEVSSKHVTEVVDETDEVSSKHCTEVVDETDEVSSKHCTEVVDETD

EVSSKHVTEVVDETDEVSNHTYGRATLTWTEETTEEYZ

ID47 1260 bp
ATGCAGAATCTGAAATTTGCCTTTTCATCTATCATGGCTCACAAGATGCGTTCTTTGCTTACTATGATTGGGATTAT

TATCGGTGTTTCATCAGTTGTTGTGATTATGGCTTTGGGTGATTCCCTATCTCGTCAAGTCAATAAAGATATGACTA

AATCTCAGAAAAATATTAGCGTCTTTTTCTCTCCTAAAAAAAGTAAAGACGGGTCTTTTACTCAGAAACAAATCAGC

TTTTACGGTTTCTGGAAAGGAAGAGGAAGTTCCTGTTTGAACCGCCAAAACCGCAAGAATCCTGGGTCCAAGAGGC

AGCTAAACTGAAGGGAGTGGATAGTTACTATGTAACCAATTCAACGAATGCCATCTTGACCTATCAAGATAAAAA

GGTTTGAGAATGCTAATTTGACAGGTGGAAACAGAACTTACATGGACGCTGTTAAGAATGATATTATTGCAGGTCG

TAGTCTGAGAGAGCAAGATTTCAAAGAGTTTGCAAGTGTCATTTTGCTAGATGAGGAATTGTCCATTAGTTTATTT

GAATCTCCTCAAGAGGCTATTAACAAGGTTTGTAGAAGTCAATGGATTTAGTTACCGGGTCATTGGGGTTTATATA

GTCCGGAGGCTAAAAGATCAAAAATATATGGGTTTGGTGGCTTGCCTATTACTACCAATATCTCCCTTGCTGCGAA

TTTTAATGTAGATGAAATAGCTAATATTGTCTTTCGAGTGAATGATACCAGTTTAACCCCAACTCTGGGTCCAGAA

CTGGCACGAAAAATGACAGAGCTTGCAGGCTTACAACAGGGAGAATACCAGGTGGCAGATGAGTCCGTTGTATTT

GCAGAAATTCAACAATCGTTTAGTTTTATGACGACGATTATTAGTTCCATCGCAGGGATTTCTCTCTTTGTTGGAG

GAACTGGTGTCATGAACATCATGCTGGTTTCGGTGACAGAGCGCACTCGTGAGATTGGTCTTCGTAAGGCTTTGGG

TGCAACAGCTGCCAATATTTTAATTCAGTTTTTGATTGAATCCATGATTTTGACCTTGTTAGGTGGCTTAATTGGCT

TGACAATTGCAAGTGGTTTAACTGCCTTAGCAGGTTTGTACTGCAAGGTTTAATAGAAGGTATAGAAGTTGGAGT

AAGGCATCGAAACTTGATCCAATTGAAGCCCTTCGTTATGAATGA

MQNLKTATSSIMAHKMRLTMIGIIIGVSSVVVIMALGDSLSRQVNKDMTKSQKNISVTTSPKKSKDGSTQKQSATFVS

GKEEEVPVEPPKPQESWVQEAAKLKGVDSYYVTNSTNAILTYQDKKVENANLTGGNRTYMDAVKNEIIAGPTLPTQDT

KEFASVILLDEELSISLFESPQEAINKVVEVNGFSYRVIGVYTSPEAKRSKIYGFGGLPITTNISLAANFNVDEIANIVFRVN

DTSLTPTLGPELARKMTELAGLQQGEYQVADESVVFAEIQQSFSFMTTIISSIAGISLFVGGTGVMNIMLVSTERTREIG

LRALGATRANILIQTLIESMILTLLGGLIGLTIASGLTALAGLLLQGLIEGTEVGVSIPVALTSTTVSTVGMIFGVLPANK

ASKLDPIEALRYEZ

ID48 705 bp
CTGATGAAGCAACTAATTAGTCTAAAAAATATCTTCAGAAGTTACCGTAATGGTGACCAAGAACTGCAGGTTCTC

AAAAATATCAATCTAGAAGTGAATGAGGGTGAATTTGTAGCCATCATGGGACCATCTGGGTCTGGTAAGTCCACT

CTGATGAATACGATTGGCATGTTGGATACACCAACCAGTGGAGAATATTATCTTGAAGGTCAAGAAGTGGCTGGG

CTTGGTGAAAAACAACTAGCTAAGGTCCGTAACCAACAAATCGGTTTTGTCTTTCAGCAGTTCTTTCTTCTATCGA

AGTCAATGCTCTGCAAAATGTAGAATTGCCCTTGATTTACGCAGGAGTTTCGTCTTCAAAACGTCGCAAGTTGGC

TGAGGAATATTTAGACAAGGTTGAATTGACAGAACGTAGTCACCATTTACCTTCAGAATTATCTGGTGGTCAAAA

GCAACGTGTAGCCATTGCGCGTGCCTTGGTAAACAATCCTTCTATTATCCTAGCGGATGAACCGACAGGAGCCTTG

GATACCAAAACAGGTAACCAAATTATGCAATTATTGGTTGATTTGAATAAAGAAGGAAAAACCATTATCATGGTA

ACGCATGAGCCTGAGATTGCTGCCTATGCCAAACGTCAGATTGTCATTCGGGATGGGGTCATTTCGTCTGACAGTG

CTCAGTTAGGAAAGGAGGAAAACTAA

MMKQLISLKNIRSYRNGDQELQVLKNINLEVNEGEFVAIMGPSGSGKSTLMNTIGMLDTPTSGEYYLEGQEVAGLGEK

QLAKVRNQQIGFVFQQFFLLSKLNALQNVELPLIYAGVSSSRRKLAEEYLDKVELTERSHHLPSELSGGQKQRVAIARA

LVNNPSIILADEPTGALDTKTGNQIMQLLVDLNEGKTIIMVTHEPEIAAYAKRQIVIRDGVISSDSAQLGKEENZ

ID49 1200 bp
ATGAAGAAAAAGAATGGTAAAGCTAAAAAGTGGCAACTGTATGCAGCAATCGGTGCTGCGAGTGTAGTTGTATTG

GGTGCTGGGGGGATTTTACTCTTAGACAACCTTCTCAGACTGCTCTAAAAGATGAGCCTACTCATCTTGTTGTTG

CCAAGGAAGGAAGCGTGGCCTCCTCTGTTTTATTGTCAGGGACAGTAACAGCAAAAAATGAACAATATGTTTATT

TTGATGCTAGTAAGGGTGATTTAGATGAAATCCTTGTTTCTGTGGGCGATAAGGTCAGCGAAGGGCAGGCTTTAGT

CAAGTACAGTAGTTCAGAAGCGCAGGCGGCCTATGATTCAGCTAGTCGAGCAGTAGCTAGGGCAGATCGTCATAT

CAATGAACTCATCAAGCACGAAATGAAGCCGCTTCAGCTCCGGCTCCACAGTTACCAGCGCCAGTAGGAGGAGA

AGATGCAACGGTGCAAAGCCCAACTCCAGTGGCTGGAAATTCTGTTGCTTCTATTGACGCTCAATTGGGTGATGCC

CGTGATGCGCGTGCAGATGCTGCGGCGCAATTAAGCAAGGCTCAAAGTCAATTGGATGCAACAACTGTTCTCAGT

ACCCTAGAGGGAACTGTGGTCGAAGTCAATAGCAATGTTTCTAAATCTCCAACAGGGGCGAGTCAAGTTATGGTT

CATATTGTCAGCAATGAAAATTTACAAGTCAAGGGAGAATTGTCTGAGTACAATCTAGCCAACCTTTCTGTAGGTC

AAGAAGTAAGCTTTACTTCTAAAGTGTATCCTGATAAAAAATGGACTGGGAAATTAAGCTATATTTCTGACTATCC

TAAAAACAATGGTGAAGCAGCTAGTCCAGCAGCCGGGAATAATACAGGTTCTAAATACCCTTATACTATTGATGT

GACAGGCGAGGTTGGTGATTTGAAACAAGGTTTTTCTGTCAACATTGAGGTTAAAAGCAAAACTAAGGCTATTCTT

GTTCCTGTTAGCAGTCTAGTAATGGATGATAGTAAAAATTATGTCTGGATTGTGGATGAACAACAAAAGGCTAAA

AAAGTTGAGGTTTCATTGGGAAATGCTGACGCAGAAAATCAAGAAATCACTTCTGGTTTAACGAACGGTGCTAAG

GTCATCAGTAATCCAACATCTTCCTTGGAAGAAGGAAAAGAGGTGAAGGCTGATGAAGCAACTAATTAG

MKKKNGKAKKWQYLYAAIGAASVVVLGAGGILLFRQPSQTALKDEPTHLVVAKEGVASSVLLSGTVTAKNEQYVYFD

ASKGDLDEILVSVGDKSEGQALVKYSSSEAQAAYDSASRAVARADRHINELNQARNEAASAPAPQLPAPVGGEDATV

QSPTPVAGNSVAISDAQLGDARDARADAAAQLSKAQSQLDATTVLSTLEGTVVEVNSNVSKSPTGASQVMVHIVSNEN

LQVKGELSEYNLANLSVGQEVSFTSKVYPDKKWTGKLSYISDYPKNNGEAASPAAGNNTGSKYPYTIDVTGEVGDLKQ

GFSVNIEVKSKTKAILVPSSLVMDDSKNYVWIVDEQQKAKKVEVSLGNADAENQEITSGLTNGAKVISNPTSSLEEGKE

VKADEATNZ

D50 759 bp
ATGTCACGTAAACCATTTATCGCTGGTAACTGGAAAATGAACAAAAATCCAGAAGAAGCTAAAGCATTCGTTGAA

GCAGTTGCATCAAAACTTCCTTCATCAGATCTTGTTGAAGCAGGTATCGCTGCTCCAGCTCTTGATTTGACACTG

TTCTTGCTGTTGCAAAAGGCTCAAACCTTAAAGTTGCTGCTCAAAACTGCTACTTTGAAAATGCAGGTGCTTTCAC

TGGTGAAACTAGCCCACAAGTTTTGAAAGAAATCGGTACTGACTACGTTGTTATCGGTCACTCAGAACGCCGTGA

CTACTTCCATGAAACTGATGAAGATATCAACAAAAAAGCAAAAGCAATCTTTGCGAACGGTATGCTTCCAATCAT

CTGTTGTGGTGAATCACTTGAAACTTACGAAGCTGGTAAAGCTGCTGAATTCGTAGGTGCTCAAGTATCTGCTGCA

TTGGCTGGATTGACTGCTGAACAAGTTGCTGCCTCAGTTATCGCTTATGAGCCAATCTGGGCTATCGGTACTGGTA

AATCAGCTTCACAAGACGATGCACAAAAAATGTGTAAAGTTGTTCGTGACGTTGTAGCTGCTGACTTTGGTCAAG

AAGTCGCAGACAAAGTTCGTGTTCAATACGGTGGTTCTGTTAAACCTGAAAATGTTGCTTCATACATGGCTTGCCC

AGACGTTGACGGTGCCCTTGTAGGTGGTGCGTCACTTGAAGCTGAAAGCTTCTTGGCTTTGCTTGACTTTGTAAAA

TAA

MSRKPFIAGNWKMNKNPEEAKATVEAVASKLPSSDLVEAGIAAPALDLTTVLAVAKGSNLKVAAQNCYFENAGAFTG

ETSPQVLKEIGTDYVVIGHSERRDYFHETDEDINKKAKAIFANGMLPIICCGESLETYEAGKAAEFVGAQVSAALAGLTA

EQVAASVIAYEPIWAIGTGKSASQDDAQKMCKVVRDVVAADFGQEVADKVRVQYGGSVKPENVASYMACPDVDGAL

VGGASLEAESFLALLDFVKZ

ID51 1473 bp
TTGAAAACAAAAATTGGATTAGCAAGTATCTGTTTACTAGGCTTGGCAACTAGTCATGTCGCTGCAAATGAAACTG

AAGTAGCAAAAACTTCGCAGGATACAACGACAGCTTCAAGTAGTTCAGAGCAAAATCAGTCTTCTAATAAAAGCG

AAACGAGCGCAGAAGTACAGACTAATGCTGCTGCCCACTGGGATGGGGATTATTATGTAAAGGATGATGGTTCTA

AAGCTCAAAGTGAATGGATTTTTGACAACTACTATAAGGCTTGGTTTTATATTAATTCAGATGGTCGTTACTCGCA

GAATGAATGGCATGGAAATTACTACCTGAAATCAGGTGGATATATGGCCCAAAACGAGTGGATCTATGACAGTAA

TTACAAGAGTTGGTTTTATCTCAAGTCAGATGGGGCTTATGCTCATCAAGAATGGCAATTGATTGGAAATAAGTGG

TACTACTTCAAGAAGTGGGGTTACATGGCTAAAAGCCAATGGCAAGGAAGTTATTTCTTGAATGGTCAAGGAGCT

ATGATGCAAAATGAATGGCTCTATGATCCAGCCTATTCTGCTTATTTTTATCTAAAATCCGATGGAACTTATGCTA

ACCAAGAGTGGCAAAAAGTGGGCGGCAAATGGTACTATTTCAAGAAGTGGGGCTATATGGCTCGGAATGAGTGGC

AAGGCAACTACTATTTGACTGGAAGTGGTGCCATGGCGACTGACGAAGTGATTATGGATGGTACTCGCTATATCTT

TGCGGCCTCTGGTGAGCTCAAAGAAAAAAAAGATTTGAATGTCGGCTGGGTTCACAGAGATGGTAAGCGCTATTT

CTTTAATAATAGAGAAGAACAAGTGGGAACCGAACATGCTAAGAAAGTCATTGATATTAGTGAGCACAATGGTCG

TATCAATGATTGGAAAAAGGTTATTGATGAGAACGAAGTGGATGGTGTCATTGTTCGTCTAGGTTATAGCGGTAA

AGAAGACAAGGAATTGGCGCATAACATTAAGGAGTTAAACCGTCTGGGAATTCCTTATGGTGTCTATCTCTATAC

CTATGCTGAAAATGAGACCGTGCTGAGAGTGACGCTAAACAGACCATTGAACTTATAAAGAAATACAATATGAAC

CTGTCTTACCCTATCTATTATGATGTTGAGAATTGGGAATATGTAAATAAGAGCAAGAGAGCTCCAAGTGATACA

GGCACTTGGGTTAAAATCATCAACAAGTACATGGACACGATGAAGCAGGCGGGTTATCAAAATGTGTATGTCTAT

AGCTATCGTAGTTTATTACAGACGCGTTAAAACACCCAGATATTTTAAAACATCTAATCTGGGTAGCGGCCTATA

CGAATGCTTTAGAATGGGAAAACCCTCATTATTCAGGAAAAAAAGGTTGGCAATATACCTCTTCTGAATACATGA

AAGGAATCCAAGGGCGCGTAGATGTCAGCGTTTGGTATTAA

MKTKIGLASICLLGLATSHVAANETEVAKTSQDTTTASSSSEQNQSSNKTQTSAEVQTNAAAHWDGDYYVKDDGSKAQ

SEWIFDNYYKAWFYINSDGRYSQNEWHGNYYLKSGGYMAQNEWIYDSNYKSWFYLKSDGAYAHQEWQLIGNKWYY

FKKWGYMAKSQWQGSYFLNGQGAMMQNEWLYDPAYSAYFYLKSDGTYANQEWQKVGGKWYYFKKWGYMARNE

WQGNYYLTGSGAMATDEVIMDGTRYIFAASGELKEKKDLNVGWVHRDGKRYFFNNREEQVGTEHAKKVIDISEHNG

RINDWKKVIDENEVDGVIVRLGYSGKEDKELAHNIKELNRLGIPYGVYLYTYAEETDAESDAKQTIELIKKYNMNLSY

PIYYDVENWEYVNKSKRAPSDTGTWVKIINKYMDTMKQAGYQNVYVYSYRSLLQTRLKHYDILKHVNWVTYTTNAL

EWENPHYSGKKGWQYTSSEYMKGIQGRVDVSVWYZ

ID52 774 bp
ATGAAAAAATTTGCCAACCTTTATCTGGGACTGGTCTTTCTGGTCCTCTACCTGCCTATCTTTTACTTGATTGGCTA

TGCCTTTAATGCTGGTGATGATATGAATAGCTTTACAGGTTTTAGCTGGACTCACTTTGAAACCATGTTTGGAGAT

GGGAGACTCATGCTGATTTTGGCTCAGACATTTTTCTTGGCCTTCCTATCAGCCTTGATAGCGACCATTATCGGGA

CTTTTGGTGCCATTTACATCTACCAGTCTCGTAAGAAATACCAAGAAGCCTTTCTATCACTCAATAATATCCTCAT

GGTTGCGCCTGACGTTATGATTGGTGCTAGCTTCTTGATTCTCTTTACCCAACTCAAGTTTTCATTGGCTTTTTGA

CCGTTCTATCTAGTCACGTGGCCTTCTCCATTCCTATCGTGGTCTTGATGGTCTTGCCTCGACTCAAGGAAATGAA

TGGCGACATGATTCATGCGGCCTATGACTTGGGAGCTAGTCAATTTCAGATGTTCAAGGAAATCATGCTTCTTTAC

CTGACTCCGTCTATCATTACTGGTTATTTCATGGCCYCACCTATTCGTTAGATGACTTTGCCGTGACCTTCTTTGT

AACAGGAAATGGCTTTTCAACCCTATCAGTCGAGATTTACTCTCGTGCTCGCAAGGGGATTTCCTTAGAAATCAAT

GCCCTGTCTGCTCTAGTCTTTCTCTTTAGTATTATCCTAGTTGTAGGTTATTACTTTATCTCTCGTGAGAAGGAGGA

GCAAGCATGA

MKKFANLYLGLVFLVLYLPIFYLIGYAFNAGDDMNSFTGFSWTHFETMFGDGRLMLILAQTFFLAFLSALIATIIGTFGA

IYIYQSRKKYQEAFLSLNNILMVAPDVMIGASFLILFTQLGSLGFLTVLSSHVAFSIPIVVLMVLPRLKEMNGDMIHAAY

DLGASQFQMPKEIMLPYLTPSITTGYFMAFTYSLDDFAVTFFVTGNGFSTLSVEIYSRARKISLEINALSALVFLFSIILVV

GYYTTSREKEEQAZ

ID59 1071 bp
ATGAAAAAAATCTATTCATTTTTAGCAGGAATTGCAGCGATTATCCTTGTCTTGTGGGGAATTGCGACTCATTTAG

ATAGTAAAATCAATAGTCGAGATAGTCAAAAATTGGTTATCTATAACTGGGGAGACTATATCGATCTTGAACTCTT

GACTCAGTTTACAGAAGAAACAGGAATTCAAGTTCAGTACGAGACTTTTGACTCCAACGAAGCCATGTACACTAA

GATAAAGCAGGGTGGAACGACCTACGATATTGCCATTCCAAGTGAATACATGATTAACAAGATGAAGGACGAAG

ACTTCTGGTTCCGCTGATTATTCAAAAATTGAAGGAATCGAAAATATCGGACCAGAGTTTTTCATCCAGTCCTT

TGACCCAGGTAATAAATTCTCCATCCCTTACTCTGGGGAACCTTAGGAATTGTCTACAACGAAACCATGGTAGAT

GAAGCGCCTGAGCATTGGGATGACCTTTGGAAGCCGGAGTATAAGAATTCTATCATGCTCTTTGATGGGGCGCT

GAGGTGCTGGGACTAGGACTCAATTCCCTCGGCTACAGCCTCAACTCCAAGGATCTGCAGCAGTTGGAAGAGACA

GTGGATAAGCTCTACAAACTGACTCCAAATATCAAGGCTATCGTTGCGGACGAGATGAAGGGCTATATGATTCAG

AATAATGTTGCAATCGGCGTGACCTTCTCTGGTGAAGCCAGCCAAATGTTAGAAAAAAATGAAAATCTACGTTAT

GTGGTACCGACAGAGGCCAGCAATCTTTGGTTTGACAATATGGTCATTCCCAAAACAGTTAAAAACCAAAACTCA

GCCTATGCCTTTATCAACTTTATGTTGAAACCTGAAAATGCTCTCCAAAATGCGGAGTATGTCGGCTATTCAACAC

CAAACCTACCAGCGAAGGAATTGCTCCCAGAGGAAACAAAGGAAGATAAGGCCTTCTATCCCGATGTTGAAACCA

TGAAACACCTAGAAGTTTATGAGAAATTTGACCATAAATGGACAGGGAAATATAGCGACCTCTTCCTACAGTTTA

AAATGTATCGGAAGTAG

MKKIYSFLAGIAAIILVLWGIATHLDSKINSRDSQKLVIYNWGDYIDPELLTQFTEETGIQVQYETFDSNEAMYTKIKQGG

TTYDIAIPSEYMINKMKDEDLLPVDYSKIEGIENIGPEFLNQSFDPGNKFSIPYFWGTLGIVYNETMVDEAPEHWDDLW

KPEYKNSIMLFDGAREVLGLGLNSLGYSLNSKDLQQLEETVDKYKLTPNIKAIVADEMKGYMIQNNVAIGTFSGEAS

QMLEKNENLRYVVPTEASNLWFDNMVIPKTVKNQNSAYAFINFMLKPENALQNAEYVGYSTPNLPAKELLPETTKED

KATYPDVETMKHLEVYEKTDHKWTGKYSDLTLQTKMYRKZ

ID61 1851 bp
ATGAATAAAAAACTAACAGATTATGTGATTGATCTGGTGGAAATTTTAAATAAACAACAAAAGCAGGTTTTCTGG

GGAATATTTGATATTTTCAGTATGGTGGTTTCCCATCATTGTATCTTATATTTTATTTTATGGGCTGATTAATCCAGC

ACCTGTTGACTACATTATCTATACGAGTTTGGCCTTCCTGTTCTATCAATTGATGATTGGTTTTTGGGGGTTGAACG

CGAGCATTAGTCGTTACAGCAAGATTACGGATTTCATGAAAATCTTTTTTGGTGTGACTGCTAGCAGTGTCTTGTC

ATATAGTATCTGTTATGCCTTCTTGCCACTCTTCTCCATCCGTTTCATCATTCTCTTTATCTTGTTGATACCTTCTT

GATTTTATTGCCACGGATTACTTGGCAGTTAATCTACTCCAGACGCAAAAAAGGTAGTGGTGATGGAGAACACCG

TCGGACCTTCTTGATTGGTGCCGGTGATGGTGGGGCTCTTTTTATGGATAGTTACCAACATCCAACCAGTGAATTA

GAACTGGTCGGTATTTTGGATAAGGATCTAAGAAAAAGGGTCAAAAACTTGGTGGTATTCCTGTTTTGGGCTCTT

ATGACAATCTGCCTGAATTAGCCAAACGCCATCAAATCGAGCGTGTCATCGTTGCGATTCCGTCGTCTGGATCCGTC

AGAATATGAGCGTATCCTGCAGATGTGTAATAAGCTGGGTGTCAAATGTTACAAGATGCCTAAGGTTGAAACTGT

TGTTCAGGGCCTTCACCAAGCAGGTACTGGCTTCCAAAAAATTGATATTACGGACCTTTTGGGTCGTCAGGAAATC

CGTCTTGACGAATCGCGTCTGGGTGCAGAACTGACAGGTAAGACCATCTTAGTCACAGGAGCTGGAGGTTCAATC

GGTTCTGAAATCTGTCGTCAAGTTAGTCGCTTCAATCCTGAACGCATTGTCTTGCTCGGTCATGGGGAAAACTCAA

TCTACCTTGTTTATCATGAATTGATTCGTAAGTTCCAAGGGATTGATTATGTACCTGTGATTGCGGACATTCAAGA

CTATGATCGTTTGTTGCAAGTCTTTGAGCAGTACAAACCTGCTATTGTTTATCATGCGGCAGCCCACAAGCATGTT

CCTATGATGGAGCGCAATCCAAAAGAAGCCTTCAAAAACAATATCCGTGGAACTTACAATGTTGCTAAGGCTGTT

GATGAAGCTAAAGTGTCTAAGATGGTTATGATTTCGACAGATAAGGCAGTCAATCCACCAAATGTTATGGGAGCA

ACCAAGCGCGTGGCGGAGTTGATTGTCACTGGCTTTAACCAACGTAGCCAATCAACCTACTGTGCAGTTCGTTTTG

GGAATGTTCTTGGTAGCCGTGGTAGTGTCATTCCAGTCTTTGAACGTCAGATTGCTGAAGGTGGGCCTGTAACGGT

GACAGACTTCGTATGACCCGTTACTTTATGACCATTCCAGAAGCTAGCCGTCTGGTTATCCATGCTGGTGCTTAT

GCCAAAGATGGGGAAGTCTTTATCCTTGATATGGGCAAACCAGTCAAGATTTATGACTTGGCCAAGAAGATGGTG

CTTCTAAGTGGCCACACTGAAAGTGAAATTCCAATCGTTGAAGTTGGAATCCGCCCAGGTGAAAAACTCTACGAA

GAACTCTTGGTATCAACCGAACTCGTTGATAATCAAGTTATGGATAAGATTTTCGTGGTAAGGTAATTTTCATGC

CTTTAGAATCCATCAATCAAAAGATTGGAGAGTTCCGCACTCTCAGTGGAGATGAGTTGAAGCAAGCTATTATCG

CCTTTGCTAATCAAACAACCCACATTGAATAA

MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILFYGLINPAPVDYIIYTSLAFLFYQLMIGFWGLNASISRY

SKITDFMKIFFGVTASSVLSYSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGAGDGGALF

MDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIERVIVAIPSLDPSEYERILQMCNKLGVKCYK

MPKVETVVQGLHQAGTGFQKIDITDLLGRQEIRLDESRLGAELTGKTILVTGAGGISGSEICRQVSRFNPERIVLLGHGEN

SIYLVYHELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFNNIRGTYVAKAVD

EAKVSKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTYCAVRFGNVLGSRGSVIPFERQIAEGGPVTVTDFR

MTRYFMTIPEASRLVIHAGAYAKDGEVFTLDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGRPGEKLYEELLVSTELV

DNQVMDKKTVGKVNVMPLEINQKIGETRThSGDELKQATIATANQTHIEZ

ID101 1338 bp
ATGATTGAACTTTATGATAGTTACAGTCAAGAAAGTCGAGATTTACATGAAAGTCTAGTCGTACTGGTCTTTCTC

AACTTGGAGTGGTCATCGATGCAGATGGTTTTCTGCCTGATGGTCTGCTTTCTCCTTTTACCTATTATCTAGGTTAC

GAGGATGGAAAACCTCTCTATTTTAATCAAGTTCCCGTTTCAGATTTTTGGGAAATTTTAGGAGATAATCAGTCTG

CTTGTATTGAAGATGTGACGCAGGAGAGGGCTGTCATTCATTATGCTGATGGAATGCAGGCTCGCTTGGTTAAACA

GGTAGACTGGAAAGACCTAGAAGGTCGAGTACGTCAGGTTGACCACTACAATCGCTTCGGAGCTTGTTTTGCTAC

AACGACTTATAGCGCAGATAGCGAGCCGATTATGACAGTTTACCAAGATGTCAATGGTCAACAAGTTTTACTGGA

AAACCATGTGACGGGTGATATCTTATTGACTTTGCCAGGTCAGTCCATGCGTTACTTTGCAAATAAAGTTGAATTT

ATCACCTTCTTTTTGCAAGATTTGGAAATAGATACCAGTCAGCTTATCTTTAATACTCTAGCGACTCCTTTCTTGGT

TTCCTTCCATCATCCAGATAAATCTGGCTCGGATGTCTTGGTATGGCAGGAACCTCTCTATGATGCCATTCCAGGT

AATATGCAGTTGATTTTGGAAAGTGATAATGTGCGTACTAAGAAGATCATCATTCCAAATAAGGCGACTTATGAG

CGCGCTTTAGAGTTAACTGACGAGAAATACCATGATCAGTTTGTGCACTTGGGTTATCATTACCAGTTCAAACGTG

ATAATTTCCTAAGACGAGATGCCTTAATCTTGACCAATTCAGATCAGATTGAGCAAGTAGAAGCAATCGCAGGAG

CCTTGCCTGATGTCACTTTCCGTATTGCAGCGGTGACAGAGATGTCTTCTAAGCTCTTAGACATGCTTTGCTATCCT

AATGTGGCCCTTTACCAGAACGCTAGTCCACAGAAGATTCAGGAGCTGTATCAATGTCGGATATTTACTTGGATA

TAAACCACAGTAATGAGTTGCTACAGGCAGTGCGTCAGGCCTTTGAGCACAATCTCTTGATTCTTGGCTTTAATC

GACGGTGCACAATAGACTTTATATCGCTCCAGACCATCTATTTGAAAGTAGTGAGTTGCTGCTTTGGTTGAGACC

ATTAAATTGGCCCTTTCAGATGTTGATCAAATGCGTCAGGCACTTGGCAAACAAGGCCAACATGCAAATTATGTTG

ACTTGGTGAGATATCAGGAAACCATGCAAACTGTTTTAGGAGGCTAA

MIELYDSYSQESRDLHESLVATGLSQLGVVIDADGFLPDGLLSPFTYYLGYEDGKPLYFNQVPVSDFWEILGDNQSACIE

DVTQERAVIHYADGMQARLVKQVDWKDLEGRVRQVDHYNRFGACFATTTYSADSEPIMTVYQDVNGQQVLLENHV

TGDILLTLPGQSMRYFANKVEFITFFLQDLEIDTSQLIFNTLATPFLVSTFHHPDKSGSDVLVWQEPLYDAIPGNMQLILES

DNVRTKKIIIPNKATYERALELTDEKYHDQFVHLGYHYQFKRDNFLRRDALILTNSDQIEQVEAIAGALPVTFRIAAT

EMSSKLLDMLCYPNVALYQNASPQKIQELTQLSDIYLDINHSNELLQAVRQAFEHNLLILGFNQTVHNRLYIAPDHLFE

SSEVAALVETIKLALSDVDQMRQALGKQGQHANYVDLVRYQETMQTVLGGZ

ID102 1512 bp
ATGACAATTTACAATATAAATTTAGGAATTGGTTGGGCTAGTAGCGGTGTTGAATACGCTCAAGCCTATCGTGCTG

GTGTTTTCGGAAATTAAATCTGTCCTCTAAGTTTATVTTTACAGATATGATTTTAGCCGATAATATTCAGCACTTA

ACAGCCAATATTGGTTTTGATGATAATCAGGTTATCTGGCTTTATAATCATTTCACAGATATCAAAATTGCACCTA

CTAGCGTGACAGTGGATGATGTCTTGGCTTACTTTGGTGGTGAAGAAAGTCACAGAGAAAAAAAATGGCAAGGTTT

TACGTGTATTCTTTTTTGACCAAGATAAGTTTGTAACCTGTTATTTGGTTGATGAGAACAAGGACTTGGTTCAACA

TGCCGAGTATGTTTTTAAGGGAAACCTGATTCGGAAGGATTACTTTTCTTATACGCGTTATTGTAGCGAGTATTTT

GCTCCCAAGGACAATGTTGCAGTCTTATACCAACGACTTTTTATAATGAAGTGACGGGACTCCAGTCTATGATATT

TGATGAATCAAGGGAAGGAAGAAGTTTATCATTTCAAGGATAAGATTTTCTATGGAAAGCAAGCTTTTGTGCGTG

CCTTTATGAAATCTTTGAATTGAATAAGTCTGATTTGGTCATTTTCGATAGGGAGACAGGTATTGGACAGGTTGT

GTTTGAGGAAGCACAGACAGCACATCTAGCGGTAGTTGTTCATGCGCAGCATTATAGTGAAAATGCTACAAATGA

GGACTATATCCTTTGGAATAACTATTATGACTATCAGTTTACCAATGCAGATAAGGTTGACTTCTTTATCGTGTCT

ACTGATAGACAAAATGAAGTTCTACAAGAGCAATTTGCCAAATATACTCAGCATCAGCCAAAGATTGTTACCATT

CCTGTAGGCAGTATTGATTCCTGACAGATTCAAGTCAAGGGCGCAAACCATTTTCATTGATTACGGCTTCACGTC

TTGCCAAAGAAAAGCACATTGATTGGCTTGTGAAAGCTGTGATTGAAGCTCATAAGGAGTTACCGGAACTAACCT

TGATATCTATGGTAGTGGTGGAGAAGATTCTCTGCTTAGAGATATTATTGCAAATCATCAGGCAGAGGACTATAT

CCAACTCAAGGGGCATGCGGAACTTTCGCAGATTTATAGCCAGTATGAGGTCTACTTAACGGCTTCTACCAGCGA

AGGATTTGGTCTGACCTTGATGGAAGCTATTGGTTCAGGTCTACCTCTAATTGGTTTTGATGTGCCTTATGGTAATC

AGACCTTTATAGAGGATGGGCAAAATGGTTATTTGATTCCAAGTTCATCTGACCATGTAGAAGACCAAATCAAGC

AAGCTTATGCCGCTAAGATTTGTCAATTGTATCAAGAAAATCGTTTGGAAGCTATGCGTGCCTATTTTACCAAAT

TGCAGAAGGCTTCTTGACCAAAGAAATTTTAGAAAAGTGGAAGAAAACAGTAGAGGAGGTGCTCCATGATTGA

MTIYNINLGIGWASSGVEYAQAYRAGVFRKLNLSSKFIFTDMILADNIQHLTANIGFDDNQVIWLYNHFTDIKIAPTSVT

VDDVLAYFGGEESHREKNGKVLRVFFFDQDKFVTCYLVDENKDLVQHAEYVFKGNLIRKDYFSTRYCSEYFAPKDN

VAVLYQRTFYNEDGTPVYDILMNQGKEEVYNFKDKIFYGKQAFVRAFMKSLNLNKSDLVILDRETGIGQVVFEEAQTA

HLAVVVHAEHYSENATNEDYILWNNYYDYQFTNADKVDFFIVSTDRQNEVLQEQFAKTYTQHQPKIVTTPVGSIDSLTDS

SQGRKPFSLITASRLAKEKHIDWLVKAVIEAHKELPELTFDIYGSGGEDSLLREIIANHQAEDYIQLKGHAELSQIYSQYE

VYTASTSEGFGLTLMEAIGSGLPLIGFDVPYGNQTFIEDGQNGYLIPSSSDHVEDQIKQAYAAKICQLYQENRLEAMRA

YSYQIAEGTLTKEILEKWKKTVEEVLMDZ

D103 2292 bp
ATGTCCTCTCTCGGATCAAGAATTTAGTAGCTAAAACAGTAGAGTTTCGTCAGCGTCTTTCCGAGGGAGAAAGTC

TAGACGATATTTTGGTTGAAGCTTTTGCTGTGGTGCGTGAAGCAGATAAGCGGATTTAGGGATGTTTCTTATGA

TGTTCAAGTCATGGGAGCTATTGTCATGCACTATGGAAATGTTGCTGAGATGAATACGGGGGAAGGTAAGACCTT

GACAGCTACCATGCCTGTCTATTTGAACGCTTTTTCAGGAGAAGGAGTGATGGTTGTGACTCTAATGATATTTA

TCAAAGCGTGATGCCGAGGAAATGGGTCAAGTTTATCGTTTTCTAGGATTGACCATTGGTGTACCATTTACGGAAG

ATCCAAAGAAGGAGATGAAAGCTGAAGAAAAGAAGCTTATCTATGCTTCGGATATCATCTACACAACCAATAGTA

ATTTAGGTTTTGATTATCTAAATGATAACCTAGCCTCGAATGAAGAAGGTAAGTTTTTACGACCGTTTAACTATGT

GATTATTGATGAAATTGATGATATCTTGCTTGATAGTGCACAAACTCCTCTGATTATTGCGGGTTCTCCTCGTGTTC

AGTCTAATTACTATGCGATCATTGATACACTTGTAACAACCTTGGTCGTGGAAGGAGAGGATTATATCTTTAAAGAGGA

GAAAGAGGAGGTTTGGCTCACTACTAAGGGGGCCAAGTCTGCTGAGAATTTCCTAGGGATTGATAATTTATACAA

GGAAGAGCATGCGTCTTTTGCTCGTCATTTGGTTTATGCGATTCGAGCTCATAAGCTCTTTACTAAAGATTGGAC

TATATCATTCGTGGAAATGAGATGGTACTGGTTGATAAGGGAACAGGGCGTCTAATGGAATGACTAAACTTCAA

GGAGGTCTCCATCAGGCTATTGAAGCCAAGGAACATGTCAAATTATCTCCTGAGACGCGGGCTATGGCCTCGATC

ACCTATCAGAGTCTTTTTAAGATGTTAATAAGATATCTGGTATGACAGGGACAGGTAAGGTCGCGGAAAAAGAG

TTTATTGAAACTTACAATATGTCTGTAGTACGCATTCCAACCAATCGTCCGAGACAACGGATTGACTATCCAGATA

ATCTATATATCACTTTACCTGAAAAAGTGTATGCATCCTTGGAGTACATCAAGCAATACCATGCTAAGGGAAATCC

TTTACTCGTTTTTGTAGGCTCAGTTGAAATGTCTCAACTCTATTCGTCTCTCTTGTTTCGTGAAGGGATTGCCCATA

ATGTCCTAAATGCTAATAATGCGGCGCGTGAGGCTCAGATTATCTCCGAGTCAGGTCAGATGGGGGCTGTGACAG

TGGCTACCTCTATGGCAGGACGTGGTACGGATATCAAGCTTGGTAAAGGAGTCGCAGAGCTTGGGGGTTGATTG

TTATTGGGACTGAGCGGATGGAAAGTCAGCGGATCGACCTACAAATCGTGGCCGTTCTGGTCGTCAGGGAGATC

CTGGTATGAGTAAATTTTTTGTATCCTAGAGGATGATGTTATCAAGAAATTTGGTCCATCTTGGGTGCATTAAA

GTACAAAGACTATCAGGTTCAAGATATGACTCAACCGGAAGTATTGAAAGGTCGTAAATATACCGGTTAGTCGA

AAAGGCTCAGCATGCCAGTGATAGTGCTGGACGTTCAGCACGTCGTCAGACTGGAGTATGTGTAAAGTATGAA

TATACAACGGGATATAGTCTATAAAGAGAGAAATCGTCTAATAGATGTCTCGTGACTAGAGGATGTTGTTGTG

GATATCATTGAGAGATATACAGAAGAGGTAGCGGCTGATCACTATGCTAGTCGTGAATTATTGTTTCACTTTATTG

TGACCAATATTAGTTTTCATGTTAAAGAGGTTCCAGATTATATAGATGTAACTGACAAAACTGCAGTTCGTAGCTT

TATGAAGCAGGTGATTGATAAAGAACTTTCTGAAAAGAAAGAATTACTTAATCAACATGACTTATATGAACAGTT

TTTACGACTTTCACTGCTTAAAGCCATTGATGACAACTGGGTAGAGCAGGTAGACTATCTACAACAGCTATCCATG

GCTATCGGTGGTCAATCTGCTAGTCAGAAAAATCCAATCGTAGAGTACTATCAAGAAGCCTACGCGGGCTTTGAA

GCTATGAAAGAACAGATTCATGCGGATATGGTGCGTAATCTCCTGATGGGGCTGGTTGAGGTCACTCCAAAAGGT

GAAATCGTGACTCATTTTCCATAA

MSSLSDQELVAKTVEFRQRLSEGESLDDILVEAFAVVREADKRILGMFPYDVQVMGAIVMHYGNVAEMNTGEGKTLT

ATMPVYLNAFSGEGVMVVTPNEYLSKRDAEEMGQVYRFLGLTIGPFTEDPKKEMKAEEKKLIYASDIIYTTNSNLGF

DYLNDNLASNEEGKFLRPFNYYVIIDDILLDSAQTPLIIAGSPRVQSNYYAIIDTLVTTLVEGDYIFKEEKEEVWLTTK

GAKSAENFLGIDNLYKEEHASFARHLVYAIRAHKLFTKDKYIIRGNEMVLVDKGTGRLMEMTKLQGGLHQAIEAKEH

VKLSPETRAMASITYQSLFKMFNKISGMTGTGKVAEKEFIETYNMSVVRIPTNRPRQRIDYPDNLYITLPEKVYASLEYIK

QYHAKGNPLLVFVGSVEMSQLYSSFREGIAHNVLNANNAAREAQIISESGQMGAVTVATSMAGRTDIKLGKGVAE

LGGLIVIGTERMESQRIDLQIRGRSGRQGDPGMSKFFVSLEDDVIKKFGPSWVHKKYKDYQVQDMTQPEVLKGRKYRK

LVEKAQHASDSAGRSARRQTLEYAESMNIQRDIVYKERNRLIDGSRDLEDVVVDIIERYTEEVAADHYASRELLFHFIVT

NISFHVKEVPDYIDVTDKTAVRSFMKQVIDKELSEKKELLNQHDLYEQFLRSLLKAIDDNWVEQVDTLQQLSMAIGG

QSASQKNPIVEYYQEAYAGFEAMKEQIHADMVRNLLMGLVEVTPKGEIVTHFPZ

ID104 879 bp
ATGAAACAAGAATGGTTTGAAAGTAATGATTTTGTAAAAACAACAAGCAAGAACAAGCCTGAAGAGCAAGCTCA

AGAGGTTGCAGACAAGGCTGAAGAAAGGATACCCGATCTCGATACACCAATTGAAAAAAATACTCAGTTAGAGG

AGGAAGTCTCTCAAGCTGAAGTCGAATTGGAAAGCCAGCAAGAAGAGAAAATTGAAGCTCCTGAAGACAGTGAA

GCGAGAACAGAAATAGAAGAAAAGAAGGCATCTAATTCTACTGAAGAAGAGCCAGACCTTTCTAAAGAAACAGA

AAAAGTCACTATAGCTGAAGAGAGCCAAGAAGCTCTTCCTCAGCAAAAAGCAACCACGAAAGAGCCACTTCTTAT

CAGTAAATCTTTAGAAAGTCCTTATATCCCCGACCAAGCTCCAAAATCTAGGGATAAATGGAAAGAGCAAGTGCT

TGATTTTTGGTCTTGGCTAGTGGAAGCGATCAAATCTCCTACAAGTAAGTTGGAAACAAGTATCACACACAGTTAC

ACAGCCTTTCTCTTGCTCATTCTGTTTTCTGCATCTTCCTTTTTCTTTAGTATCTATCACATCAAACATGCTTACTAT

GGACATATAGCAAGCATTAACAGTCGCTTCCCTGAGCAGCTAGCTCCTTTAACTCTTTTTTCTATCATCTCTATCCT

AGTAGCGACAACACTCTTCTTCTTTTCATTCCTCTTGGGTAGTTTCGTTGTGAGACGATTTATCCACCAGGAAAAG

GACTGGACGCTAGACAAGGTTCTCCAACAATATAGTCAACTCTTGGCAATTCCAATCTCCTCACTGCTATTGCTAG

TTTCTTTGCTTTCTTTGATAGCCTACGATTTACAGCCCTCTTGTGTGTGA

MKQEWTESNDTVKTTSKNKPEEQAQEVADKAEETPDLDTPIEKNTQLEEEVSQAEVELTQQEEKIEAPEDSEARTEIE

EKKASNSTEEEPDLSKETEKVTIAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDFWSWLVEAIKS

PTSKLETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLTLFSIISILVATTLFFFSFLLGSFVVRRFIH

QEKDWTLDKVLQQYSQLLAIPISSLLLLVSLLSLIAYDLQPSCVZ

ID106 327 bp
TGTACTTTCCAACATCCTCTGCCTTGATTGAATTTCTCATCTTGGCTGTACTGGAGCAGGGTGATTCTTATGGTTA

TGAGATTAGCCAAACCATTAAGCTGATCGCTAATATCAAAGAATCCACACTCTATCCCATTCTCAAAAAATTGGA

AGGCAATAGCTTTCTGACAACCTATTCTAGAGAGTTCCAAGGTCGCATGCGCAAATACTACTCCTTGACAAACGG

TGGTATAGAGCAGCTCTTGACCCTAAAAGATGAATGGGCACTCTATACAGACACCATCAATGGCATCATAGTAAGG

GAGTATCCGCCATGACAAGAACTGA

MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLYPILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLT

LKDEWALYTDTINGIIEGSIRHDKNZ

D108 954 bp
ATGGATTTTGAAAAAATTGAACAAGCTTATATCTATTTACTAGAGAATGTCCAAGTCATCCAAAGTGATTTGGCGA

CCAACTTTTATGACGCCTTGGTGGAGCAAAATAGCATCTATCTGGATGGTGAAACTGAGCTAAACCAGGTCAAAG

ACAACAATCAGGCCCTTAAGCGTTTAGCACTACGCAAAGAAGAATGGCTCAAGACCTACCAGTTTCTCTTGATGA

AGGCTGGGCAAACAGAACCCTTGCAGGCCAATCACCAGTTTACACCGGATGCTATTGCTTTGCTTTTGGTGTTTAT

TGTGGAAGAGTTGTTTAAAGAGGAGGAAATTACTATCCTCGAAATGGGTTCTGGGATGGGAATTCTAGGCGCTAT

TTTCTTGACCTCGCTTACTAAAAAGGTGGATTACTTGGGAATGGAAGTGGATGATTTGCTGATTGATCTGGCAGCT

AGCATGGCAGATGTAATTGGTTTGCAGGCTGGCTTTGTCCAAGGAGATGCCGTTCGCCCACAAATGCTCAAAGAA

AGCGATGTGGTCATCAGTGACTTGCCTGTCGGCTATTATCCTGATGATGCCGTTGCGTCGCGCCATCAAGTTGCTT

CTAGCCAAGAACATACTTACGCCCATCACTTGCTCATGGAACAAGGGCTTAAGTACCTCAAGTCAGACGGATACG

CTATTTTTCTAGCTCCGAGTGATTTGTTGACCAGTCCTCAAAGTGATTTGTTAAAAGAATGGCTGAAAGAAGAGGC

GAGTCTGGTTGCTATGATTAGTCTGCCTGAAAATCTCTTTGCTAATGCCAAACAATCTAAGACTATTTTTATCTTAC

AGAAGAAAAATGAAATAGCAGTAGAGCCTTTTGTTTATCCACTTGCTAGCTTGCAAGATGCAAGTGTTTTAATGAA

ATTTAAAGAAAATTTTCAAAAATGGACTCAAGGTACTGAAATATAA

GQTEPLQANHQVPDAIALLLVTTVEELTKEEETTLEMGSGMGILGATTLTSLTVDYLGMEVDDLLIDLTSMADVI

GLQAGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGLKYLKSDGYAIFLAPSD

LLTSPQSDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFILQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQG

TEIZ

ID110 1902 bp
ATGATTATTTTACAAGCTAATAAAATTGAACGTTCTTTTGCAGGAGAGGTTCTTTTCGATAATATCAACCTGCAGG

TTGATGAACGAGATCGGATTGCTCTTGTTGGGAAAAATGGTGCAGGTAAGTCTACTCTTTTGAAGKETTTAGTTGG

AGAAGAGGAGCCAACTAGCGGAGAAATCAATAAGAAAAAAGATATTTCTCTGTCTTACCTAGCCCAAGATAGCCG

TTTTGAGTCTGAAAATACCATCTACGATGAAATGCTTCATGWITTAATGATTTGCGTCGGACGGAGAGACAACTG

CGTCAGATGGAGCTGGAGATGGGTGAAAAGTCTGGTGAGGATTTGGATAAACTGATGTCAGATTATGACCGCTTA

TCTGAGAATTTTCGCCAAGCAGGTGGCTTTACCTATGAAGCTGATATTCGAGCGATTTTGAATGGATTCAAGTTTG

ACGAGTCTATGTGGCAGATGAAAATTGCTGAGCTTTCTGGTGGTCAAAATACTCGTTTGGCACTTGCCAAAATGCT

CCTTGAAAAGCCCAATCTCTTGGTCTTGGACGAGCCAACTAACCACTTGGATATTGAAACCATCGCCTGGCTAGA

GAATTACTTGGTAAACTATAGCGGTGCCCTCATTATCGTCAGCCACGACCGTTATTTCTTGGACAAGGTTGCGACA

ATTACGCTAGATTTGACCAAGCATTCCTTGGATCGCTATGTGGGGAATTACTCTCGTTTTGTCGAATTGAAGGAGC

AAAAGCTAGTTACTGAGGCAAAAAACTATGAAAAGCAACAGAAGGAAATCGCTGCTCTGGAAGACTTTGTCAATC

GCAATCTAGTTCGTGCTTCAACGACTAAACGTGCTCAATCTCGCCGTAAACAACTAGAAAAAATGGAGCGTTTGG

ACAAGCCTGAAGCTGGCAAGAAAGCAGCCAACATGACCTTCCAGTCTGAAAAAACGTCGGGCAATGTTGTTTTGA

CTGTTGAAAATGCAGCGTTGGCTATGACGGGGAAGTCTTGTCACAACCTATCAACCTAGATCTTCGTAAGATGAA

TGCTGTCGCTATCGTTGGTCCAAATGGTATCGGCAAGTCAACCTTATCAAGTCTATTGTGGACCAGATTCCTTTT

ATCAAGGGAGAAAAGCGCTTTGGCGCTAATGTTGAGGTTGGTTACTATGACCAAACCCAAAGCAAGCTGACACCA

AGTAATACGGTGCTGGATGAATCTGGAATGAITTTCAAACTGACACCAGAAGTTGAAATCCGCAACCGTCTTGGA

GCCTTCCTTTTCTCAGGAGATGATGTTAAAAAATCAGTCGGCATGCTATCTGGTGGCGAAAAAGCTCGTTTGCTTT

TAGCTAAATTGTCTATGGAAAACAATAACTTTTTGATCTGGATGAGCCGACCAACCACTTGGATATTGATAGTAA

GGAAGTGCTAGAAAATGCCTTGATTGACTTTGATGGAACCTTGCTGTTTGTCAGTCATGATCGTTACTTTATCAAT

CGTGTGGCAACTCATGTTTTGGAATTGTCTGAGAATGGTTCAACTCTCTACCTTGGAGATTACGACTACTATGTTG

AGAAGAAAGCAACAGCAGAAATGAGTCAGACTGAGGAAGCTTCAACTAGCAATCAAGCAAAGGAAGCAAGTCCA

GTCAATGACTATCAGGCCCAGAAAGAAAGTCAAAAAGAAGTTCGCAAACTCATGCGACAAATCGAAAGTCTAGA

AGCTGAAATTGAAGAGCTAGAAAGTCAAAGCCAAGCCATTTCTGAACAAATGTTGGAAACAAACGATGCCGACA

AACTCATGGAATTACAGGCTGAGCTGGACAAAATCAGCCATCGTTCAGGAAGAAGCTATGCTTGAGTGGGAAGAAT

TATCAGAGCAGGTGTAA

MIILQANKIERSFAGEVLFDNINLQVDERDRIALVGKNGAGKSTLLKILVGEEEPTSGEINKKKDISLSYLAQDSRFESENT

IYDEMLHVTNDLRRTERQLRQMELEMGTKSGEDLDKLMSDYDRLSENTRQAGGTTYEADIRATLNGTKTDESMWQMK

IAELSGGQNTRLALAKMLLEKPNLLVLDEPTNHLDLETTAWLENYLVNYSGALHVSHDRYFLDKVATTTLDLTKHSLDR

YVGNYSRTELKEQKLVTEAKNYEKQQKEIAALEDFVNRNLVRASTTKRAQSRRKQLEKMERLDKPEAGKKAANMTF

QSEKTSGNVVLTVENAAVGYDGEVLSQPINLDLRKMNAVATVGPNdIIGKSTTTKSWDQIFITKGEKRTGANVSVGYYDQ

TQSKLTPSNTVLDELWNDTKLTPEVEIRNRLGATLTSGDDVKKSVGMLSGGEKARLLLAKLSMENNNPLILDEPTNHL

DIDSKEVLENALIDPDGTLLTVSHDRYTTNRVATHVLSLSENGSTLYLGDYDYYVEKKATAEMSQTEEASTSNQAKEAS

PVNDYQAQKESQKEVRKLMRQIESLEAEIEELESQSQATSEQMLETNDADKLMELQAELDKISHRQEEAMLEWEELSEQ

VZ

ID111 1189 bp
ATGAATCGCTATGCAGTGCAGTTGATTAGCCGTGGGGCTATCAATAAAATGGGAAATATGCTCTATGATTATGGA

AATAGTGTCTGGTTGGCTTCTATGGGGACTATAGGACAGACAGTTTTAGGAATGTATCAGATTTCTGAGCTCGTCA

CATCTATTCTCGTCAATCCCTTTGGCGGAGTTATTTCAGACCGTTTTTCTCGTCGTAAGATTTTAATGACGGCAGAT

CTTGTTTGTGGGATTCTTTGTCTGGCTATTTCTTTCATAAGGAATGATAGCTGGATGATTGGCGCTTTGATTGTTGC

TAACATTGTGCAGGCTATTGCTTTTGCCTTTTCTCGCACAGCCAATAAAGCTATCATAACTGAAGTGGTGGAGAAA

GATGAGATTGTGATCTATAATTCTCGCTTAGAGCTGGTTTTGCAGGTTGTAGGTGTTAGCTCTCCTGTTCTTTCTT

CCTTGTTTTACAGTTGCAAGTCTCCATATGACGCTACTGCTAGACTCGCTGACTTTTTTCATTGCTTTTGTTCTAG

TGGCTTTCCTTTCCAAAAGAGGAAGCAAAAGTTCAAGAGAAAAAGGCTTTTACTGGGAGAGATATTTTTGTAGATA

TCAAGGATGGGTTACACTATATCTGGCATCAGCAAGAAATTTTCTTCCTTTTGCTGGTAGCTTCCAGCGTTAATTT

CTTTTTTGCAGCTTTTGAATTTCTACTTCCCITTTCGAATCAGCTTTACGGGTCAGAAGGAGCCTATGCAAGTATTT

TAACTATGGGGGCTATTGGTTCCATCATTGGGGCTCTTCTAGCTAGTAAAATTAAAGCTAATATTTATAATCTTTT

GATTTTACTGGCTTTGACAGGTGTCGGAGTTTTTATGATGGGATTACCACTTCCAACTTTTCTTTCTTTTCTGGAA

ATTTAGTTTGTGAATTGTTATGACGATTTTTAATATTCACTTTTTTACTCAAGTACAAACCAAGGTTGAGAGCGAA

TTTCTTGGAAGAGTACTGAGTACAATTTTTACCTTAGCTATTCTATTTATGCCTATTGCAAAAGGATTTATGACAGT

CTTGCCAAGTGTCCATCTTTATTCTTTCTTGATTATTGGACTTGGAGTTGTAGCCTTATATTTCTTAGCTCTCGGAT

ATGTTCGAACTCATTTTGAAAAATTGATATAA

MNRYAVQLISRGAINKMGNMLYDYGNSVWLASMGTTGQTVLGMYQISELVTSILVNPTGGVISDRPSRRTTTLMTADLV

CGILCLATSTTRNDSWMIGALIVANIVQATATATSRTANKATTTEVVEKDEIVIYNSRLELVLQVVGVSSPVLSTLVLQTASL

HMTLLLDSLTTTTATVLVATLPKEEAKVQEKKATGRDTTVDIKDGLHYIWHQQETTTLLLVASSVNTTTAATALPFSN

QLYGSEGAYASILTMGATGSIIGALLSKKANIYNLLILLALTGVGVTMMGLPLIFPLSTSGNLVCELTMTTTNIHFFTQV

QTKVESETLGRVLTTTTLATLTMPIAKGTMTVLPSVMLYSTLLIGLGVVALYTLALGYVRTHTEKLIZ

ID113 2466 bp
ATGCAAAATCAATTAAATGAATTAAAACGAAAAATGCTGGAATTTTTCCAGCAAAAACAAAAAAATAAAAAATCA

GCTAGACCTGGCAAGAAAGGTTCAAGTACCAAAAAATCTAAAACCTTAGATAAGTCAGCCATTTTCCCAGCTATT

TTACTGAGTATAAAAGCCTTATTTAACTTACTCTTTGTACTCGGTTTTCTAGGAGGAATGTTGGGAGCTGGGATTG

CTTTGGGATACGGAGTGGCCTTATTTGACAAGGTTCGGGTGCCTCAGACAGAAGAATTGGTGAATCAGGTCAAGG

ACATCTCTTCTATTTCAGAGATTACCTATTCGGACGGGACGGTGATTGCTTCCATAGAGAGTGATTTGTTGCGCAC

TTCTATCTCATCTGAGCAANTTTCGGAAAATCTGAAGAAGGCTATCATTGCGACAGAAGATGAACACTTTAAAGA

ACATAAGGGTGTAGTACCCAAGGCGGTGATCGTGCGACCTGGGGAAATTTGTAGGTTTGGGTTTCCTCTAGTGGG

GGTTCAACCTTGACCCAGCAACTAATTAAACAGCAGGTGGTTGGGGATGCGCCGACCTTGGCTCGTAAGGCGGCA

GAGATTGTGGATGCTCTTGCCTTGGAACGCGCCATGAATAAAGATGAGATTTTAACGACCTATCTCAATGTGGCTC

CCTTTGGCCGAAATAATAAGGGACAGAATATTGCAGGGGCTCGGCAAGCAGCTGAGGGAATTTTCGGTGTAGATG

CCAGTCAGTTGACTGTTCCTCAAGCAGCATTTTTAGCAGGACTTCCACAGAGTCCCATTACTTACTCTCCTTATGA

AAATACTGGGGAGTTGAAGAGTGATGAAGACCTAGAAATTGGCTTAAGACGGGCTAAGGCAGTTCTTTACAGTAT

GTATCGTACAGGTGCATTAAGCAAAGACGAGTATTCTCAGTACAAGGATTATGACCTTAAACAGGACTTTTTACC

ATCGGGCACGGTTACAGGAATTTCACGAGACTATTTATACTTTACAACTTTGGCAGAAGCTCAAGAACGTATGTAT

GACTATCTAGCTCAGAGAGACAATGTCTCCGCtAAGGAGTTGAAAAATGAGGCAACTCAGAAGTTTTATCGAGAT

TTGGCAGCCAAGGAAKTTGAAAATGGTGGTTATAAGATTACTACTACCATAGATCAGAAAATTCATTCTGCCATG

CAAAGTGCGGTTGCTGATTATGGCTATCTTTTAGACGATGGAACAGGTCGTGTAGAAGTAGGGAATGTCTTGATG

GATAACCAAACAGGTGCTATTCTAGGCTTTGTAGGTGGTCGTAATATCAAGAAAATCAAAATAATCATGCCTTTG

ATACCAAACGTTCGCCAGCTTCTACTACCAAGCCCTTGCTGGCCTACGGTATTGCTATTGACCAGGGCTTGATGGG

AAGTGAAACGATTCTATCTAACTATCCAACAAACTYTGCTAATGGCAATCCGATTATGTATGCTAATAGCAAGGG

AACAGGAATGATGACCTTGGGAGAAGCTCTGAACTATTCATGGAATATCCCTGCTTACTGGACCTATCGTATGCTC

CGTGAAAAGGGTGTTGATGTCAAGGGTTATATGGAAAAGATGGGTTACGAGATTCCTGAGTACGGTATTGAGAGC

TTGCCAATGGGTGGTGGTATTGAAGTCACAGTTGCCCAGCATACCAATGGCTATCAGACCTTAGCTAATAATGGA

GTTTATCATCAGAAGCATGTGATTTCAAAGATTGAAGCAGCAGATGGTAGAGTGGTGTATGAGTATCAGGATAAA

CCGGTTCAAGTCTATTCAAAAGCTACTGCGACGATTATGCAGGGATTGCTACGAGAAGTTCTATCCTCTCGTGTGA

CAACAACCTTCAAGTCTAACCTGACTTCTTTAAATCCTACTCTGGCTAATGCAGATTGGATTGGGAAGACTGGTAC

AACCAACCAAGACGAAAATATGTGGCTCATGCTTTCGACACCTAGATTAACCCTAGGTGGCTGGATTGGGCATGA

TGATAATCATTCATTGTCACGTAGAGCAGGTTATTCTAATAACTCTAATTACATGGCTCATCTGGTAAATGCGATT

CAGCAAGCTTCCCCAAGCATTTGGGGGAACGAGCGCTTTGCTTTAGATCCTAGTGTAGTGAAATCGGAAGTCTTG

AAATCAACAGGTCAAAAACCAGAGAAGGTTTCTGTTGAAGGAAAAGAAGTAGAGGTCACAGGTTCGACTGTTACC

AGCTATTGGGCTAATAAGTCAGGAGCGCCAGCGACAAGTTATCGCTTTGCTATTGGCGGAAGTGATGCGGATTAT

CAGAATGCTTGGTTAGTATTGTGGGGAGTCTACCAACTCCATCCAGCTCCAGCAGTTCAAGTAGTAGTTCTAGCG

ATAGCAGTAACTCAAGTACTACACGACCTCTCTTCAAGGGCGAGACGATAA

MQNQLNELKRKMLETTQQKQICNKKSARPGKKGSSTKKSKTLDKSATTPATLLSIKALTNLLTVLGTLGGMLGAGIALGY

GVALPPKVRVPQTEELVNQVKDISSJETYSDGTVIASlESDLLRTSISSEQISENLKKAHATEDEHTKEHIKVVPKAVTR

ATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEILTTYLNVAPFGRNNKGQNIAGA

RQAAEGTTGVDASQLTVPQAAPLAGLPQSPTTYSPYENTGELKSDEDLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDY

DLKQDFLPSGTVTGISRDYLYTTTLAEAQERMYDYLAQRDNVSAKELKNEATQKFYRDLAAKEIENGGYKTTTTTDQKI

HSAMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQG

LMGSETTLSNYPTNTANGNPIMYANSKGTGMMTLGEALNYSWNIPAYVTTYRMLRBKGVDVKGYMEKMGYEIPEYGIE

SLPMGGGIEVTVAQHTNGYQTLANNGVYNQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLREVLSSRVTT

TFKSNLTSLNTTLANADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGMDDNHSLSRRAGYSNNSNYMAHLVNAIQQA

SPSIWGNEREALDPSVVKSEVLKSTGQKPEKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRTATGGSDADYQNAWSSI

VGSLTTPSSSSSSSSSSSDSSNSSTTRPSSSRARRZ

ID114 1974 bp
ATGAAAAAATTTATGTAAGTCCAATTTTTCCTATTCTAGTAGGATTGATTGCGTTTGGAGTCTTATCCACTTTCAT

TATTTTTGTTAATAATAATCTGTTGACGGTTTTAATTTTGTTTCTTTTTGTAGGAGGCTATGTTTTTTTATTTAAGAA

ACTGAGAGTGCATTATACAAGGAGTGATGTAGAACAGATACAGTATGTAAACCACCAAGCGGAAGAAAGTTTGAC

AGCTCTATTGGAACAGATGCCTGTAGGTGTTATGAAATTGAATTTATCTTCTGGAGAGGTTGAGTGGTTTAATCCC

TATGCTGAATTGATTTTGACCAAGGAAGATGGTGATTTTGATTTAGAAGCTGTTCAAACGATTATCAAGGCTTCAG

TAGGAAATCCGTCTACTTATGCCAAGCTTGGTGAGAAGCGTTATGCTGTTCATATGGATGCTTCTTCCGGTGTTTT

GTATTTTGTAGATGTATCCAGGGAACAAGCCATAACAGATGAATTGGTAACAAGTAGACCAGTGATTGGGATTGT

CTCTGTGGATAATTATGATGATTGGAGGATGAAACTCTGAGTCAGATATTAGTCAAATCAJTTAGTTTTGTAGCT

AATTTTATATCAGAGTTCAGAAAAACACATGATGTTTTCTCGTCGGGTAAGTATGGATCGKTTTTATCTATTTAC

TGACTACACGGTGCTTGAGGGCTTGATGAATGATAAATTTCTGTTATTGATGCTTTCAGAGAAGAGTCGAAACAG

AGACAGTTGCCCTTGACCTTAAGTATGGGATTTTCTTATGGCGATGGAAATCATGATGAGATAGGGAAAGTTGCTT

TGCTCAATTTGAACTTGGCTGAAGTACGTGGTGGCGACCAGGTGGTTGTTAAGGAAAACGACGAAACGAAAAATC

CAGTTTATTTTGCTGGTGGGTCTGCTGCTTCAATCAAGCGTACACGGACTCGTACGCGCGCTATGATGACAGCTAT

TTCAGATAAGATTCGGAGTGTAGATCAGGTTTTTTTAGTCGGTCACAAAAATTTAGACATGGATGCTTTGGGCTCT

GCTGTAGGTATGCAGTTTGTTCGCCAGCAATGTGKTTGAAAATAGCTATGCTCTTTTATGATGAAGAACAAATGTCTC

CAGATATTGAACGAGCTGTTTCATTCATAGAAAAAGAAGGAGTTACGAAGTTGTTGTCTGTTAAGGATGCAATGG

GGATGGTGACCAATCGTTCTTTGTGATTCTTGTAGACCATTCAAAGACAGCCTTAACATTATCAAAAGAATTTTA

TGATTTATTTACCCAAACCATTGTTATTGACCACCATAGAAGGGATCAGGATTTTCCAGATAATGCGGTTATTACT

TATATCGAAAGTGGTGCAAGTAGTGCCAGTGAGTTTGGTAACGGAATTGATTCAGTTCCAGAATTCTAAGAAAAAT

CGTTTGAGTCGTATGCAAGCAAGTGTCTTGATGGCTGGTATGATGTTGGATACTAAAAATTTCACCTCGCGAGTAA

CTAGTCGGACATTTTGATGTTTGCTAGCTATCTCAGAACGCGCGGAAGTGATAGTATTGCTATCCAGGAAATCGCTGC

GACAGATTTTGAAGAATATCGTGAGGTCAATGAACTTATTTTACAGGGGCGTAAATTAGGTTCAGATGTACTAATA

GCAGAGGCTAAGGACATGAAATGCTATGATACAGTTGTTATTAGTAAGGCAGCAGATGCCATGTTAGCCATGTCA

GGTATTGAAGCGAGTTTTGTTCTGCGAAGAATACACAAGGATLTATCTCTATCTCAGCTCGAAGTCGTAGTAAAC

TGAATGTACAACGGATTATGGAAGAGTTTAGGCGGTGGAGGCCACTTTAATTTTGGCAGCAGCTCAAATTAAAGATG

TAACCTTGTCAGAAGCAGGTGAAAAACTGACAGAAATTGTATTAAATGAAATGAAGGAAAAGGAGAAAGAAGAA

TGA

MKKTYVSPTTPILVGLIATGVLSTTTTTVNNNLLTVLILTLTVGGYVTLTKKLRVHYTRSDVEQIQYVNHQABESLTALLE

QMPVGVMKLNLSSGEVEWFNPYAELILTKEDGDFDLEAVQTIIKASVGNPSTYAKLGEKRYAVHMDASSGVLYTVDVS

REQATTDELVTSRPTTGIVSVDNYDDLEDETSESDISQINSTVANTTSETSEKHMMPSRRVSMDRPYLTTDYTVLEGLMN

DKTSVIDATREESKQRQLPLTLSMGTSYGDGNHDEIGKVALLNLNLAEVRGGDQVVVKENDETKNPVYTGGGSAASIK

RTRTRTRAMMTATSDKIRSVDQVTVVGHKNLDMDALGSAVGMQLTASNVIENSYALYDEEQMSPDIERAVSTTEKEGV

TKLLSVKDAMGMVTNRSLLILVDHSKTALTLSKETYDLTTQTTVIDNEIRRDQDTPDNAVTTYIESGASSASELVTELIQTQ

NSKKNRLSRMQASVLMAGMMLDTKNTTSRVTSRTTDVASYLRTRGSDSIATQEIAATDTEEYREVNELILQGRKLGSDV

LLAEAKDMKCYDTVVISKAADAMLAMSGIEASTVLAKNTQGTTSISARSRSKLNVQRIMEELGGGGHFNLAAAQIKDVT

LSEAGEKLTEIVLNEMKEKEKEEZ

ID115 663 bp
ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTACTTCTGAGGAATGATG

ACTCTTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATTGGGGAAGAGAACTGTCCAAATTGTATGAAAAC

AGAGTTGTCAACAAAGTGTCAAGATTGTCAACTTTGGTGTAAAGAGGGAGTTGAAGTCAGTCATAGAGCGATTTT

TACTTACAATCAAGCTATGAAGGATTfTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTTTTC

GCTTCATTTTTAAGTGAGGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATTCCCCTAAGTCCTGATAGAT

ATGCTAATAGAGGATTTAATCAGGTTGAGGGCTTGGTAGAGGCAGCAGGCTTTGAGTATCTGGATTTATTAGAGA

AAAGAGAAGAGAGAGCCAGTTCTTCTAAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAA

GTGGAGTCACTATTCCTAAAAAAATCCTACTTATAGATGATATCTATACTACAGGAGCAACTATAAATCGTGTTAA

GAAACTGTTGGAAGAAGCTGGTGCTAAGGATGTAAAAACATTTTCCCTTGTAAGATGA

MKCLLCGQTMKTVLTTSSLLLLRNDDSCLCSDCDSTTERIGEENCPNCMKTELSTKCQDCQLWCKEGVEVSHRAIFTY

NQAMKDTTSRYKTDGDILLRKVTASPLSEELKKYKEYQTVVIPLSPDRYANRGTNQVEGLVEAAGTBYLDLLEKREER

ASSSKNRSERLGTELPTTTKSGVTTPKKILLIDDIYTTGATTNRVKKLLEEAGAKDVKTTSLVRZ

ID116 1299 bp
ATGAAAGTAAATTTTAGATTATTCGGTCGTTTATTTACTGAGAATGAATTAACAGAAGAAGAACGTCAGTTGGCG

GAGAAACTTCCAGCAATGAGAAAGGAGAAGGGGAAACTTTTCTGTCAACGCTGTAATAGTACTATTCTAGAAGAA

TGGTATTTGCCCATCGGTGCTACTATTGTCGAGAGTGCTTGCTGATGAAGCGAGTCAGAAGTGATCAAACTTTAT

ACTATTTTCCGCAGGAGGATTTTCCAAAGCAAGATGTTCTCAAATGGCGCGGCCAATTAACTCCTTTTCAAGAGAA

GGTGTCAGAGGGATTGCTTCAAGTAGTAGACAAGCAAAAGCCAACCTTAGTTCATGCGGTATCAGGAGCTGGAAA

GACAGAAATGATTTATCAAGTAQTGGCTAAAGTGATCAATGCGGGTGGTGCAGTGTGTTTGGCTAGTCCTCGCAT

AGATGTTTGTTTGGAGCTGTACAAGCGCCTGCAACAGGATTTTTCTTGCGGGATAGCTTTGCTACATGGAGAATCG

GAACTTATTTCGAACACCACTAGTTGTTGCAACAACCCATCAGTTATTGAAGTTTTATCAAGCTTTYGATTTGCT

GATAGTGGATGAAGTAGATGCTTTCCTTATGTTGATAATCCCATGCTTTACCACGCTGTCAAGAATAGTGTAAAT

GAGAATGGATTGAGAATCTTTTTAACAGCGACTTCGACCAATGAGTTAGATAkAAAGGTCCGTTTAGGAGAACTA

AAAAGACTGAATTTACCGAGACGGTTCATGGAAATCCGTTGATTATTCCAAAACCAATTIGGTTATCGGATTTTA

ATCGCTACTTAGACAAGAATCGTTTGTCACCAAAGTTAAAGTCCTATATTGAGAAGCAGAGAAAGACAGCTTATC

CGTTACTCATTTTTGCTTCAGAAATTAAGAAAGGGGAGCAGTTAGCAGAAATCTTACAGGAGCAATTTCCAAATG

AGAAAATTGGCTTTGTATGTCTGTAACAGAGGATCGATTTAGAGCAAGTACAAGCTTTTCGAGATGGAGAACTGA

CAATACTTATCAGTACGACAATCTTGGAGCGCGGAGTACCTCCCTTGTGTGGATTTTTTTCGTAGTAGAGGCCAA

TCATCGTTTGTTTACCAAGTCTAGTTGATTCAGATTGGTGGACGAGTTGGACGAAGCATTGATAGACCGATAGGA

GATTTGCTTTTCTCCATGATGGGTTAAATGCTCAATCAAGAAGGCGATTATGGAAATTCAGATGATGAATTAAGG

AGGCTGGTCTATGA

MKVNLDYLGRLFTENELTEEERQLAEKPAMRKEKGTTLTCQRCNSTTLEEWYLPIGAYYCRECLLMTRVTTSDQTTTYYF

PQEDTPKQDVLKWRGQLTPFQEKVSEGLLQVVDKQKPTLVHAVTGAGKTBMIYQVVAKVINAGGAVCLASPRIDVCL

ELYKRLQQDTSCGIALLHGESEPYTRTPL,VVATTHQLLKTYQATDLLLVDEVDATPYVDNPMLYHAVKNSVKENGLRTT

LTATSTNELDKKVRLGELKRLNLPRRTHGNPLIIPKPIWLSDINRYLDKNRLSPKLKSYIEKQRKTAYPLLIIASEIKKGE

QLAEILQEQTPNEKIGTVSSVTBDRLEQVQATRDGELTTLISTTTLERGVTTPCVDVTVVEANHRLTTKSSLIQIGGRVGRS

MDRPTGDLLTTHDGLNASIKKATKEIQMMNKBAGLZ

ID117 870 bp
ATGCAAATTCAAAAAAGTTTTAAGGGGCAGTCTCCCTATGGCAAGCTGTATCTAGTGGCAACGCCGATTGGCAAT

CTAGATGATATGACTTTTCGTGCTATCCAGACCTTGAAAGAAGTGGACTGGATTGCTGCTGAGGATACGCGCAAT

ACAGGGCTTTTGCTCAAGCATTTTGACATTTCCACCAAGCAGATCAGTTTTCATGAGCACAATGCCAAGGAAAAA

ATTCCTGATTGATTGGTTTCTTGAAAGCAGGGCAAAGTATTGCTCAGGTCTCTGATGCCGGTTTGCCTAGCATTT

CAGACCCTGGTCATGATTTAGTTAAGGCAGCTATTGAGGAAGAAATTGCAGTTGTGACAGTTCCAGGTGCCTCTGC

AGGAATTTCTGCCTTGATTGCCAGTGGTTTAGCGCCACAGCCACATATCTTTTACGGTTTTTTACCGAGAAAATCA

GGTCAGCAGAAGCAATTTTTTGGCTTGAAAAAAGATTATCCTGAAACACAGATTTTTTATGAATCACCTCATCTG

TAGCAGACACGTTGGAAAATATGTTAGAACTCTACGGTGACCGCTCCGTTGTCTTGGTCAGGGAATTGACCAAAA

TCTATGAAGAATACCAACGAGGTACATCTCTGAGTTATTAGAAAGCATTGCTGAAACGCCACTCAAGGGCGAAAT

GTCTTCTCATTGTTGAGGGTGCCAGTCAGGGTGTGGAGGAAAAGGACGAGGAAGACTTGTTCGTAGAAATTCAAA

CCCGCATCCAGCAAGGTGTGAAGAAAAACCAAGCTATCAAGGAAGTCGCTAAGATTTACCAGTGGAATAAAAGTC

AGCTCTACGCTGCCTACCACGACTGGGAAGAAAAACAATAA

MQIQKSFKGQSPYGKLYLVATPIGNLDDMTTRATQThKBVDWIAAEDTRNTGLLLKHTDISTKQISTHEHNAKEKTPKLI

GTLKAGQSIAQVSDAGLPSISDPGNDLVKAATEEEIAVVTVPGASAGISALIASGLAPQPHTTYGTLPRKSGQQKQTPGLKK

DYPETQTTYESPHRVADTLENMLEVYGDRSVVLVRBLTKIYEEYQRGTTSELLESIAETPLKGECLLIVEGASQGVEEKDE

EDLTVEIQTRIQQGVKKNQATKEVAKIYQWNKSQLYAAYHDWEEKQZ

ID118 345 bp
ATGATAAAGAAAGGAAAGGGCTGTTTTATGGACAAAAAAGAATTATTTGACGCGCTGGATGATTTTTCCCAACAA

TTATTGGTAACCTTAGCCGATGTGGAAGCCATCAAGAAAAATCTCAAGAGCCTGGTAGAGGAAAATACAGCTCTT

CGCTTGGAAAATAGTAAGTTGCGAGAACGCTTGGGTGAGGTGGAAGCAGATGCTCCTGTCAAGGCCAAGCATGTT

CGCGAAAGTGTCCGTCGTATTACCGTGATGGATTTCACGTATGTAATGATTTTTATGGACAACGTCGAGAGCAGG

ACGAAGAATGTATGTTTTGTGACGAGTTTGTTATACAGGGAGTAA

MIKKGKGCTMDKKELTDALDDFSQQLLVTLADVEAIKKNLKSLVEENTALRNSKRBRLGEVEADAPVKAKHVRES

VRRIYPDGTHVCNDTYGQRREQDEECMTCDELLYREZ

ID119 639 bp
ATGTCAAAAGGATTTTTAGTCTCTCTTGAGGGACCAGAGGGAGCAGGCAAGACCAGTGTTTTAGAGGCTCTGCTA

CCAATTTTAGAGGAAAAAGGAGTAGAGGTGTTGACGACCCGTGAACCTGGCGGAGTCTTGATTGGGGAGAAGATT

CGGGAAGTGATTTTGGATCCAAGTCATACTCAGATGGATGCTAAAACAGAGCTACTTCTCTATATTGCCAGTCGCA

GACAGCATTTGGTGGAAAAAGTTCTTCCAGCCCTTGAAGCTGGCAAGTTGGTCATCATGGATCGTTTTATCGATAG

TTCTGTTGCCTATCAGGGATTTGGTCGTGGCTAGATATTGAAGCCATTGACTGGCTCAATCAGTTTGCGACAGAT

GGCCTCAAACCCGATTTGACACTCTATTTTGACATCGAGGTGGAAGAAGGGCTGGCTCGTATTGTGTTAATAGTG

ACCGCGAGGTTAATCGTTTGGATTTGGAAGGGTTGGACTTGCATAAAAAAGTTCGTCAAGGCTACCTTTCTCTTCT

GGATAAAGAGGGAAATCGCATTGTCAAGATTGATGCTAGTCTCCCTTTGGAGCAAGTTGTGGAAACTACCAAGGC

TGTCTTGTTTGACGGAATGGGCTTGGCCAAATGA

MSKGFLVSLEGPEGAGKSVLEALLPILEEKGVEVLTTREPGGVLIGEKIREVILDPSHTQMDAKTELLLYIASTQHLVE

KVLPALEAGKLTTMDRTTDSSVAYQGTGRGLDIEATDWLNQTATGGLKPDLTLYTDTTVEEGLAANSDRTVNRLDL

EGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKAVLTDGMGLAKZ

ID120 408 bp
ATGGTAGAACAAAGAAAATCAATTACCATGAAAGATGTTGCTTTAGAAGCAGGAGTTAGTGTTGGTACTGTTTCA

CGTGTAATTAATAAAGAAAAAGGCATTAAAGAAGTAACTTTGAAAAAAGTGGAACAAGCGATTAAAACTTTGAAT

TACATTCCAGATTACTACGCTAGAGGAATGAAAAAAAATCGAACAGAAACGATTGCAATCATTGTACCAAGTATC

TGGCATCCCTTCTTTTCAGAATTTGCTATGCATGTGGAAAATGAAGTCTATAAGAGAAATAACATTTACTCTTAT

GTTCTATCAATGGTACAAATAGAGAGCAAGACTATCTGGAGATGTTGCGTCATAATAAATGTTGATGGAGTGTTG

CCATTACCTATAGGCCAATTGAACATTACTTGACGTCAGGAATTCCCTTTGTTAGTATTGACCGCACATATCAGA

GATTGCCATCCVTGTGTTTCA

MVEQRKSTTMKDVALEAGVSVGTVSRTTNKKGTTTEVTLKKVEQATTLNYIPDYYARGMKKNRTETTATTVPSIWHPFF

SEFAMHVENEVYKRNNKLLLCSINGTNEQDYLEMLRAINKVDGVVATTYRPIEHYLTSGIPTVSEDRTYSEIAIPCVS

ID126 1281 bp
TTGTTTAACAAAAATAAAGACATTCTTAATATTGCATTGCCAGCTATGGGTGAAAACTTTTTGCAGATGCTAATGG

GAATGGTGGACAGTTATGGTTGCTCATTTAGGATTGATAGCTATTTCAGGGGTTTTCAGTAGCTGGTAATATTAT

CACCATTTATCAGGCGATTTTCATCGCTCTGGGAGCTGCTATTTCCAGTGTTATTTCAAAAAGCATAGGGCAGAAA

GACCAGTCGAAGTTGGCCTATCATGTGACTGAGGCGTTGAAGATTACCTACTATTAAGTTTCCTTTTAGGATTTT

TGTCCATCTTCGCTGGGAAAGAGATGATAGGACTTTTGGGGACGGAGAGGGATGTAGCTGAGAGTGGTGGACTGT

ATCTATCTTTGGTAGGCGGATCGATTGTTCTCTTAGGTTTAATGACTAGTCTAGGAGCCTTGATTCGTGCAACGCA

TAATCCACGTCTGCCTCTCTATGTTAGTTTTTTATCCAATGCCTTGAATATTCTTTTTTCAAGTCTAGCTATTTTTGT

TCTGGATATGGGGATAGCTGGTGTTGCTGGGGGACAATTGTGTCTCGTTGGTTGGTCTTGTGATTTTGTGGTCAC

AATTAAAACTGCCTTATGGGAAGCCAACTTTTGGTTTAGATAAGGAACTGTTGACCTTGGCTTTACCAGCAGCTGG

AGAGCGACTTATGATGAGGGCThGAGATGTAGTGATCATTGCCTTGGTCGTTTCTTTTGGGACGGAGGCAGTTGCT

GGGAATGCAATCGGAGAAGTCTTGACCCAGTTTAACTATATGCCTGCCTTTGGCGTCGCTACGGCAACGGTCATG

CTGTTGGCCCGAGCAGTTGGAGAGGATGATTGGAAAAGAGTTGCTAGTTGAGTAAACAATCCTTTTGGCTTTCTC

TGTTTCCTCATGTTGCCCCTGTCCTTTTTAGTATATATGTCTTGGGTGTACCATTAACTCATCTCTATACGACTTCT

CTAGCGGTGGAGGCTAGTGTTCTAGTGACACTGTTTTCACTACTTGGGACCCCTATGACGACAGGAACAGTCATCT

ATACGGCAGTCTGGCAGGGATTAGGAAATGCACGCCTCCCTTTTTATGCGACAAGTATAGGAATGTGGTGTATCC

GCATTGGGACAGGATATCTGATGGGGATTGTGCTTGGTTGGGGdTTGCCTGGTATTTGGGCAGGGTCTCTCTTGGA

TAATGGTTTTCGCTGGTTATTTCTACGCTATCGTTACCAGCGCTATATGAGCTTGAAAGGATAG

LFKKNKDILNIALPAMGENTLQMLMGMVDSYLVAHLGLIATSGVSVAGNITTTYQATTTALGAATSSVISKSIGQKDQSKLA

YHVTEALKITLLLSFLLGFSIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYVSFL

SNALNIILFSSLATTVLDMGIAGVAWGTTVSRLVGLTTLWSQLKLPYGKGLPKELLTLALPATGERLMMTGDVVIIA

LVVSTGTEAVAGNATGEVLTQPNYMPATGVATATVMLLARAVGEGDWKRVASLSKQTTWLSLTLMLPLSTSIYVLGVP

LTTILYTTTDSLAVEASVLVTLTSLLGTPMTTGTVIYTAVWQGLGNARLPTYATSIGMWCTRIGTGYLMGIVLGWGLPGIW

AGSLLDNGTRWLTLRYRYQRYMSLKGZ

ID127 894 bp
GTGGGAAGAATTATCAGAGCAGGTGTAAAGATGGAACATCTTGGAAAAGTATTTCGTGAATTTCGAACAAGTGGA

AATTATTCTTTAAAGGAAGCAGCAGGCGAATCCTGCTCTACCTCTCAGTTATCTCGCTTTGAGCTTGGGGAGTCTG

ACCTGGCAGTCTCCCGTTTCTTTGAGATTTTGGATAACATTCATGTAACAATCGAAAATTTCATGGATAAGGCAAG

GAATTTTCATAATCATGAACATGTGTCTATGATGGCACAGATTATCCCACTTTACTATTCAAACGATATTGCAGGT

TTTCAAAAGCTTCAAAGAGAACAACTTGAAAAGTCTAAGAGTTCGACGACTCCCCTTTATTTTGAGCTGAACTGGA

TTTTGCTACAAGGTCTGATTTGTCAAAGAGATGCGAGTTATGATATGAAGCAGGATGATTTGGGTAAGGTAGCAG

ATTATCTCTTCAAAACAGAAGAATGGACCATGTATGAGTTGKTTCTTTTCGGTAACCTCTATAGTTTCTACGATGT

AGACTATGTCACTCGGATTGGTAGAGAAGTTATGGAGAGGGAGGAATTTTACCAAGAGATTAGTCGCCATAAGAG

ATTAGTGTTGATTTGGCCCTCAATTGTTACCAGCATTGTTTAGAGCATTGTCTTTTTATAATGCCAACTATTTTG

AGGCTTATACAGAGAAGATTATTGACAAAGGTATTAAGCTTTATGAGCGTAATGTTTTCCATTATTTAAAAGGTTT

TGCCTTATATCAAAAAGGACAGTGTAAAGAAGGCTGTAAGCAGATGCAAGAGGCCATGCATATTTTTGATGTGTT

AGGTCTTCCAGAGCAAGTAGCCTATTATCAGGAACACTACGAAAAATTTGTCAAAAGTTAA

VGRIIRAGVKMEHLGKVFREFRTSGNYSKEAAGESCSTSQLRFELGESDLAVSRFFEILDNIHVTIENFMDKARNFHN

HEHVSMMAQIIPLYYSNDIAGTQKLQREQLEKSKSSIIPLYTELNWILLQGLICQRDASYDMKQGDDLGKVADYLTKTEE

WTMYELILTGNLYSTYDVDYVTRIGREVMEREEPYQEISRHKRLVLILALNCYQHCLEHSSTYNANYFEAYTEKIIDKGI

KLYERNVTHYLKGTALYQKGQCKEGCKQMQEAMHTTDVLGLPEQVAYYQEHYEKTVKSZ

TABLE 3


ID1 1068 bp
ATGTCTAACATTCAAAACATGTCCCTGGAGGACATCATGGGAGAGCGCTTTGGTCGCTACTCCAAGTACATTATTC
AAGACCGGGCTTTGCCAGATATTCGTGATGGGTTGAAGCCGGTTCAGCGCCGTATTCTTTATTCTATGAATAAGGA
TAGCAATACTTTTGACAAGAGCTACCGTAAGTCGGCCAAGTCAGTCGGGAACATCATGGGGAATTTCCACCCACA
CGGGGATTCTATCTATGATGCCATGGTTCGTATGTCACAGAACTGGAAAAATCGTGAGATTCTAGTTGAAATG
CACGGTAATAACGGTTCTATGGACGGAGATCCTCCTGCGGCTATGCGTTATACTGAGGCACGTTTGTCTGAAATTG
CAGGCTACCTTCTTCAGGATATCGAGAAAAAGACAGTTCCTTTGCATGGAACTTTGACGATACGGAGAAAGAAC
CAACGGTCTTGCCAGCAGCCTTTCCAAACCTCTTGGTCAATGGTTCGACTGGGATTTCGGCTGGTTATGCCACAGA
CATTCCTCCCCATAATTTAGCTGAGGTCATAGATGCTGCAGTTTACATGATTGACCACCCAACTGCAAAGATTGAT
AAACTCATGGAATTCTGCCTGGACCAGACTTCCCTACAGGGGCTATTATTCAGGGTCGTGATGAAATCAAGAAA
GCTTATGAGACTGGGAAAGGGCGCGTGGTTGTTCGTTCCAAGACTGAAATTGAAAAGCTAAAAGGTGGTAAGGA
CAAATCGTTATTATTGAGATTCCTTATGAAATCAATAAGGCCAATCTAGTCAAGAAAATCGATGATGTTCGTGTTA
ATAACAAGGTAGCTGGGATTGCTGAGGTTCGTGATGAGTCTGACCGTGATGGTCTTCGTATCGCTATCGAACTTAA
GAAAGACGCTAATACTGAGCTTGTTCTCAACTACTTATTTAAGTACACCGACCTACAAATCACATACAACTTTAAT
ATGGTGGCGATTGACAATTTCACACCTCGTGAGGTTGGATTGTTCCAATCCTGTCTAGCTATATCGCTCACCGTCG
AGAAGTGA

MSNIQNMSLEDIMGERFGRYSKYIIQDRALPBIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKVGNIMGNFHPHGDS
SIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPPFAWNFDDTEKEPTVLP
AAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRV
VVRSKTEIEKLKGGKEQIVIIEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFK
YTDLQINYNFNMVAIDNFTPRQVGLFQSCLAISLTVEKZ

ID12 684 bp

ATGCCGACATTAGAAATAGCACAAAAAAAACTGGAGTTCATTAAGAAGGCAGAAGAATATTACAATGCCTTGTGT
ACAAATATACAGTTGAGCGGAGATAAACTAAAAGTAATTCCGTTACTTCTGTTAACCCTGGGGAAGGAAAAAACA
ACTACTTCCATAAATATAGCATGGTCGTTTGCGCGTGCAGGCTATAAAACTCTTTTGATCGATGGCGATACTCGAA
ATTCAGTTATGTTAGGAGTTTTTAAATCTCGTGAAAAAATTACAGGGCTAACAGAATTTTTATCTGGGACAGCTGA
TTTATCTCACGGTTTATGTGATACAAATATTGAAAATTATTTGTAGTTCAATCGGGATCTGTATCACCAAACCCT
ACAGCCTTGTTACAAAGTAAAAATTTAATGATATGATTGAAACATTGCGTAAATATTTTGATTATATCATTATTG
ATACACCGCCTATTGGAATTGTTATTGATGCGGCAATTATCACTCAAAAGTGTGATGCGTCCATCTTGGTAACAGC
AACAGGTGAGGCGAATAAACGTGATATCCAAAAAGCGAAACAACAATTAAAACAAACAGGGAAACTGTTCCTAG
GAGTTGTTTTAAATAAATTGGATATCTCGGTTAATAAGTATGGAGTTTACGGTTCCTATGGAAATTATGGTAAAAA
ATAA

MPTLEIAQKKLEFIKKAEEYYNALCTNIQLSGDKLKVISVTSVNPGEGKTTTSINIAWSFARAGYKTLLIDGDTRNSVML
GVFKSREKITGLTEFLSGTADLSHGLCDTNIENLFVVQSGSVSPNPTALLQSKNFNDMIETLRKYFDYIIIDTPPIGIVIDAA
IITQKCDASILVTATGEANKRDIQKAKQQLKQTGKLFLGVVLNKLDISVNKYGVYGSYGNYGKKZ

ID13 1182 bp

ATGGAGGCAAATATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCT
TTTTTAGTGGAGCCTTGGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAA
TGTTTCTGTTATTACTTATTCGGCAAACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAG
CGAATCTCTAGTGAAGGATCTGGAGTTATTTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCAC
GTTATTAATGGCGCCAGCAAAGTAGATATTCGATTGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCT
GACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCAGAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTA
GTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCCGTTAGGTTCTGAATATGCAAATACTGTCACTCA
AGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAGATGGACAAGCTATTTCTACAAAAGCCAT
CCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAATATTCAAGGGCAGGTTATCGGAAT
TACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGCAATTCCTGCAAATGATGCT
ATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCCAGATGTTCGTTCGG
TACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGAGATTG
CTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTAA
CGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

MEANMKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSV
ITYSANRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDLAV
VKISSEKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKEDGQAISTKAIQTDTAINPGNSGGP
LINIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVIV
RSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLESZ

ID15 939 bp

ATGGCAGAAATTTATCTAGCAGGTGGTTGTTTTTGGGGCCTAGAGGAATATTTTTCACGCATTTCTGGAGTGCTAG
AAACCAGTGTTGGCTACGCTAATGGTCAAGTCGAAACGACCAATTACCAGTTGCTCAAGGAAACAGACCATGCAG
AAACGGTCCAAGTGATTTACGATGAGAAGGAAGTGTCACTCAGAGAGATTTTACTTTATTATTTCCGAGTTATCGA
TCCTATCTATCAATCAACAAGGGAATGACCGTGGTCGCCAATATCGACTGGGATTTAT1ATCAGGATGAAGC
AGATTTGCCAGCTATCTACACAGTGGTGCAGGAGCAGGAACGCATGCTGGGTCGAAAGATTGCAGTAGAAGTGGA
GCAATTACGCCACTACATTCTGGCTGAAGACTACCACCAAGACTATCTCAGGAAGAATCCTTCAGGTTACTGTCAT
ATCGATGTGACCGATGCTGATAAGCCATTGATTGATGCAGCAAACTATGAAAAGCCTAGTCAAGAGGTGTTGAAG
GCCAGTCTATCTGAAGAGTCTTATCGTGTCACACAAGAAGCTGCTACAGAGGCTCCATTFACCAATGCCTATGACC
AAACCTTTGAAGAGGGGATTTATGTAGATATTACGACAGGTGAGCCACTCTTTTTTGCCAAGGATAAGTTTGCTTC
AGGTTGTGGTTGGCCAAGTTTTAGCCGTCCGATTTCCAAAGAGTTGATTCATTATTACAAGGATCTGAGGCCATGGA
ATGGAGCGAATTGAAGTTCGTTCTCGTTCAGGCAGTGCTCACTTGGGTCATGTTTTCACAGATGGACCGCGGGAGT
TAGGCGGCCTCCGTTACTGTATCAATTCTGCTTCTTTACGCTTTGTGGCCAAGGATGAGATGGAAAAAGCAGGATA
TGGCTATCTATTGCCTTACTTAAACAAATAA

MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLKETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSI
NQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDA
DKPLIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPI
SKELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNKZ

ID17 870 bp
ATGAAGATTATTGTACCTGCAACCAGTGCCAATATCGGGCCAGGTTTTGACTCGGYCGGTGTAGCTGTAACCAAGT
ATCTTCAAATTGAGGTCTGCGAAGAACGAGATGAGTGGCTGATTGAACACCAGATTGGCAAATGGATTCCACATG
ACGAGCGTAATCTCTTGCTCAAAATCGCTTTGCAAATTGTACCAGACTTGCAACCAAGACGCTTGAAAATGACCA
GTGATGTCCCTTTGGCGCGCGGTTTGGGTTCTTCCAGCTCGGTTATCGTTGCTGGGATTGAACTAGCCAACCAACT
GGGTCAACTCAACTTATCAGACCATGAAAATTGCAGTTAGCGACCAAGATTGAAGGGCATCCTGACAATGTGGC
TCCAGCCATTTATGGTAATCTCGTTATTGCAAGTTCTGTTGAAGGGCAAGTCTCTGCTATCGTAGCAGACTTTCCA
GAGTGTGATTTTCTAGCTTACATTCCAAACTATGAATTACGTACTCGCGACAGCCGTAGTGTCTTGCCTAAAAAAT
TGTCTTATAAGGAAGCTGTTGCTGCAAGTTCTATCGCCAATGTAGCGGTTGCTGCCTTGTTGGCAGGAGACATGGT
GACCGCTGGGCAAGCAATCGAGGGAGACCTCTTCCATGAGCGCTATCGTCAGGACTTGGTAAGAGAATTTGCGAT
GATTAAGCAAGTGACCAAAGAAAATGGGGCCTATGCAACCTACCTTTCTGGTGCTGGGCCGACAGTTATGGTTCT
GGCTTCTCATGACAAGATGCCAACAATTAAGGCAGAATTGGAAAAGCAACCTTTCAAAGGAAAACTGCATGACTT
GAGAGTTGATACCCAAGGTGTCCGTGTAGAAGCAAAATAA

MKIIVPATSANIGPGFDSVGVAVTKYLQIEVCEERDEWLIEHQIGKWIPHDERNLLLKIALQIVPDLQPRRLKMTSDVPLA
RGLGSSSSVIVAGIELANQLGQLNLSDHEKLQLATKIEGHPDNVAPAIYGNLVIASSVEGQVSAIVADFPECDFLAYIPNY
ELRTRDSRSVLPKKLSYKEAVAASSLANVAVAALLAGDMVTAGQAIEGDLFHERYRQDLVREFAMIKQVTKENGAYAT
YLSGAGPTVMVLASHDKMPTIKAELEKQPFKGKLHDLRVDTQGVRVEAKZ

ID20 564 bp
ATGAAATATCACGATTACATCTGGGATTTAGGTGGAACTTTACTGGATAATTATGAAACTTCAACAGCTGCATTTG
TTGAAACATTGGCACTGTATGGTATCACACAAGACCATGACAGTGTCTATCAAGCTTTAAAGGTTTCTACTCCTTT
TGCGATTGAGACATTCGCTCCCAATTTAGAGAATTTTTTAGAAAAGTACAAGGAAAATGAAGCCAGAGAGCTTGA
ACACCCGATTTTATTTGAAGGAGTTTCTGACCTATTGGAAGACATTTCAAATCAAGGTGGCCGTCATTTTTTGGTC
TCTCATCGAAATGATCAGGTTTTGGAAATTTTAGAAAAAACCTCTATAGCAGCTTATTTTACAGAAGTGGTGACTT
CTAGCTCAGGCTTTAAGAGAAAGCCAAATCCCGAATCCATGCTTTATTTAAGAGAAAAGTATCAGATTAGCTCTG
GTCTTGTCATTGGTGATCGGCCGATTGATATCGAAGCAGGTCAAGCTGCAGGACTTGATACCCACTTGTTTACCAG
TATCGTGAATTTAAGACAAGTATTAGACATATAA

MKYHDYIWDLGGTLLDNYETSTAAFVETLALYGITQDHDSVYQALKVSTPFAIETFAPNLENFLEKYKENEARELEHPI
LFEGVSDLLEDISNQGGRHFLVSHRNDQVLEILEKTSIAAYFTEVVTSSSGFKRXPNPESMLYLREKYQISSGLVIGDRPID
IEAGQAAGLDTHLFTSIVNLRQVLDIZ

ID21 1875 bp
ATGACAGAAGAAATCAAAAATCTGCAGGCACAGGATTATGATGCCAGTCAAATTCAAGTTTTAGAGGGCTTAGAG
GTCGTTCGTATGCGTCCAGGGATGTACATTGGATCAACCTCAAAAGAAGGTCTTCACCATCTAGTCTGGGAAATTG
TTGATAACTCAATTGACGAGGCCTTGGCAGGATTTGCCAGCCATATTCAAGTTTTTATTGAGCCAGATGATTCGAT
TACTGTTGTGGATGATGGGCGTGGTATCCCAGTCGATATTCAGGAAAAAACAGGCCGTCCTGCTGTTGAGACCGT
CTTTACAGTCCTTCACGCTGGAGGAAAGTTCGGCGGTGGTGGATACAAGGTTTCAGGTGGTCTTCACGGGGTGGG
GTCGTCAGTAGTTAATGCCCTTTCCACTCAATTAGACGTTCATGTTCACAAAAATGGTAAGATTCATTACCAAGAA
TACCGTCGTGGTCATGTTGTCGCAGATCTTGAAATAGTTGGAGATACGGATAAAACAGGAACAACTGTTCACTTC
ACACCGGACCCAAAAATCTTCACTGAAACAACAATCTTTCATTTTGATAAATTAAATAAACGGATTCAAGAGTTG
GCCTTTCTAAATCGCGGTCTTCAAATTTCAATTACAGATAAGCGCCAAGGTTTGGAACAAACCAAGCATTATCATT
ATGAAGGTGGGATTGCTAGTTACGTTGAATATATCAACGAGAACAAGGATCTAATCTTTGATACACCAATCTATA
CAGACGGTGAGATGGATGATATCACAGTTGAGGTAGCCATGCAGTACACAACTGGTTACCATGAAAATGTCATGA
GTTTCGCCAATAATATTCATACCCATGAAGGTGGAACACATGAACAAGGTTTCCGTACAGCCTTGACACGTGTTAT
CAACGATTATGCTCGTAAAAATAAGTTACTGAAAGACAATGAAGATAATTTAACAGGGGAAGATGTTCGCGAAGG
CTTAACTGCAGTTATCTCAGTTAAACACCCAAATCCACAGTTTGAAGGACAAACCAAGACCAAATTGGGAAATAG
CGAAGTGGTCAAGATTACCAATCGCCTCTTCAGTGAAGCTTTCTCCGATTTCCTCATGGAAAATCCACAGATTGCC
AAACGTATCGTAGAAAAAGGAATTTTGGCTGCCAAGGCTCGTGTGGCTGCCAAGCGTGCGCGTGAAGTCACACGT
AAAAAATCTGGTTTGGAAATTTCCAACCTTCCAGGGAAACTAGCAGACTGTTCTTCTAATAACCCTGCTGAAACAG
AACTCTTCATCGTCGAAGGAGACTCAGCTGGTGGATCAGCCAAATCTGGTCGTAACCGTGAGTTTCAGGCTATCCT
TCCAATTCGCGGTAAGATTTTGAACGTTGAAAAAGCAAGTATGGATAAGATTCTAGCCAACGAAGAAATTCGTAG
TCTTTTCACAGCCATGGGAACAGGATTTGGCGCAGAATTTGATGTTTCGAAAGCCCGTTACCAAAAACTCGTTTTG
ATGACCGATGCCGATGTCGATGGAGCCCACATTCGTACCCTTCTTTTAACCTTGATTTATCGTTATATGAAACCAA
TCCTAGAAGCTGGTTATGTTTATATTGCCCAACCACCAATCTATGGTGTCAAGGTTGGAAGCGAGATTAAAGAATA
TATCCAGCCGGGTGCAGATCAAGAAATCAAACTCCAAGAAGCTTTAGCCCGTTATAGTGAAGGTCGTACCAAACC
GACTATTCAGCGTTATAAGGGGCTAGGTGAAATGGACGATCATCAGCTGTGGGAAACAACCATGGATCCCGAACA
TCGCTTGATGGCTAGAGTTTCTGTAGATGATGTGCAGAAGCAGATAAAATCTTTGATATGTTGA

MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLHHLVWEIVDNSIDEALAGFASHIQVFIEPDDSITVVD
DGRGIPVDIQEKTGRPAVETVFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHV
VADLEIVGDTDKTGTTVHFTPDPKIFTETTIFDFDKLNKRIQELAFLNRGLQISITDKRQGLEQTKHYHYEGGIASYVEYI
NENKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVMSFANNIHTHEGGTHEQGFRTALTRVINDYARKNKLLKDN
EDNLTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFSDFLMENPIAKRIVEKGILAAKARVAAK
RAREVTRKKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEI
RSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPIYGVKVGSEIKEYI
QPGADQEIKLQEALARYSEGRTKPTIQRYKGLGEMDDHQLWETTMDPEHRLMARVSVDDVQKQIKSLICZ

ID54 1446 bp
ATGAGTAGACGTTTTAAAAAATCACGTTCACAGAAAGTGAAGCGAAGTGTTAATATAGTTTTGCTGACTATTTATT
TATTGTTAGTTTGTTTTTTATTGTTCTTAATCTTTAAGTACAATATCCTTGCTTTTAGATATCTTAATCTAGTGGTAA
CTGCGTTAGTCCTACTAGTTGCCTTGGTAGGGCTACTCTTGATTATCTATAAAAAAGCTGAAAAGTTTACTATTTTT
CTGTTGGTGTTCTCTATCCTTGTCAGCTGTGTCGCTCTTTGCAGTACAGCAGTTTGTTGGACTGACCAATCGTTT
AAATGCGACTTCTAATTACTCAGAATATTCAATCAGTGTCGCTCTTTTAGCAGATAGTGAGATCGAAAATCTTACG
CAACTGACGAGTGTGACAGCACCGACTGGGACTAATAATGAAAATATTCAGAAATTACTAGCTGATATCAAGTCA
AGTCAGAATACCGATTTGACGGTCAACCAGAGTTCGTCTTACTTGGCAGCTTACAAGAGTTTGATTGCAGGGGAG
ACTAAGGCCATTGTCCTAAATAGTGTCTTTGAAAACATCATCGAGTCAGAGTATCCAGACTACGCATCGAAGATA
AAAAAGATTTATACTAAGGGATTCACTAAAAAAGTAGAAGCTCCTAAGACGTCTAAGAGTCAGTCTTTCAATATC
TATGTTAGTGGAATTGACACCTATGGTCCTATTAGTTCGGTGTCGCGATCAGATGTCAACATCCTGATGACTGTCA
ATCGAGATACCAAGAAAATCCTCTTGACCACAACGCCACGTGATGCCTATGTACCAATCGCAGATGGTGGAAATA
AGTGGATATCAATTACTATGTGCGATTGAACTTCACTTCGTTTTTGAAATTGATTGATTTGTTGGGTGGAATTGATG
TTTATAATGATCAAGAATTTACTGCCCATACGAATGGAAAGTATTACCCTGCAGGCAATGTTCATCTTGATTCAGA
ACAGGCTCTCGGTTTTGTTCGTGAGCGCTACTCCCTAGCAGATGGCGATCGTGACCGCGGGGCGCCATCAACAAAA
GGTGATTGTGGCTATCCTTCAAAAATTAACGTCAACCGAAGTGCTGAAAAATTATAGTACGATCATTAATAGCTTG
CAAGATTCTATCCAAACAAATATGCCACTTGAGACCATGATAAATTTGGTCAATGCTCAGTTAGAAAGTGGAGGG
AATTATAAAGTAAATTCTCAAGATTTAAAAGGGACAGGTCGATGGATCTTCCTTCTTATGCAATGCCAGACAGTA
AATTATAAAGTAAATTCTCAAGATTTAAAAGGGACAGGTCGGATGGATCTTCCTTCTTATGCAATGCCAGACAGTA
ACCTCTATGTGATGGAAATAGATGATAGTAGTTTAGCTGTACTTAAAGCAGCTATACAGGATGTGATGGAAGGGTA
GATGA

MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAFRYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFS
ILVSSVSFAVQQFVGLTNRLNATSNYSEYSISVAVLADSEIENVTQLTSTAPTGTNNENIQKLLADIKSSQNTDLTVNQ
SSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAPKTSKSQSFNIYVSGIDTYGPISSVSRSDV
NILMTVNRDTKKILLTTTPRDAYVPIADGGNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKLIDLLGG
IDVYNDQEFTAHTNGKYYPAGNVHLDSEQALGFVRERYSLADGDRDRGRHQQKVIVAILQKLTSTEVLKNYSTIINLQ
DSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRMDLPSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGRZ

ID55 732 bp
ATGATAGACATCCATTCGCATATCGTTTTTGATGTACATGACGGTCCCAAGTCAAGAGAGGAAAGCAAGGCTCTC
TTGGCAGAATCCTACAGACAGGGGGTGCGAACCATTGTTTTCTACCTCTCACCGTCGCAAGGGCATGTTTGAAACTC
CGGAAGAGAAGATAGCAGAAAACTTTCTTCAGGTTCGGGAAATAGCTAAGGAAGTGGCGAGTGACTTGGTCATTG
CTTACGGGGCTGAAATTTATTACACACCAGATGTTCTGGATAAGCTGGAAAAAAAGCGGATTCCGACCCTCAATG
ATAGTCGTTATGCCTTGATAGAGTTTAGTATGAACACTCCTTATCGCGATATTCATAGCGCCTTGAGCAAGATCTT
GATGTTGGGAATTACTCCAGTCATTGCCCACATTGAGCGCTATGATGCTCTTGAAAATAATGAAAAACGCGTTCGA
GAACTGATCGATATGGGCTGTTACACGCAAGTAAATAGTTCACATGTCCTCAAACCCAAACTTTTTGGCGAACGTT
ATAAATTCATGAAAAAAAGAGCTCAGTATTTTTTTAGAGAGGATTTGGTTCATGTCATTGCAAGTGATATGCACAA
TCTAGACGGTAGACCTCCTCATATGGCAGAAGCATATGACCTTGTTACCCAAAAATACGGAGAAGCGAAGGCTCA
GGAACTTTTTATAGACAATCCTCGAAAAATTGTAATGGATCAACTAATTTAG

MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRRKGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEI
YYTPDVLDKLEKKRIPTLNDSRYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVELIDMGCYTQV
NSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVTOKYGEAKAOELFIDNPRKIVM
DQLIZ

ID58 3990 bp
TTGATTTATATAATCGCTATCAATATAACAATGCAATCAGGAGGTTTTGCAATGAAACATGAAAAACAACAGCGT
TTTTCTATTCGTAAATACGCTGTAGGAGCAGCTTCTGTTCTAATTGGATTTGCCTTCCAAGCACAGACTGTTGCAG
CCGATGGAGTTACTCCTACTACTACAGAAAACCAACCGACCATCCATACGGTTTCTGATTCCCCTCAATCATCCGA
AAATCGGACTGAGGAAACACCTAAAGCAGTGCTTCAACCAGAAGCTCCAAAAACTGTAGAAACAGAAACTCCAG
CTACTGATAAGGTAGCTAGTCTTCCAAAAACAGAAGAAAAACCACAAGAGGAAGTTAGTTCAACTCCTAGTGATA
AAGCAGAAGTGGTAACTCCAACTTCTGCTGAAAAAGAAACTGCTAATAAAAAGGCAAGAAGAAGCTAGCCCTAAA
AAGGAAGAAGCGAAAGAGGTTGATTCTAAAGAGTCAAATACAGACAAGACTGACAAGGATAAACCAGCTAAAAA
AGATGAAGCGAAAGCAGAGGCTGACAAACCGGCAACAGAGGCAGGAAAGGAACGTGCTGCAACTGTAAATGAAA
AACTAGCGAAAAAGAAAATTGTTTCTATTGATGCTGGACGTAAATATTTCTCACCAGAACAGCTCAAGGAAATCA
TCGATAAAGCGAAACATTATGGCTACACTGATTTACACCTATTAGTCGGAAATGATGGACTCCGTTTCATGTTGGA
CGATATGAGCATCACAGCTAACGGCAAGACCTATGCCAGTGACGATGTCAAACGCGCCATTGAAAAAGGTACAAA
TGATTATTACAACGATCCAAACGGCAATCACTTAACAGAAAGTCAAATGACAGATCTGATTAACTATGCCAAAGA
TAAAGGTATCGGTCTCATTCCGACAGTAAATAGTCCTGGACACATGGATGCGATTCTCAATGCCATGAAAGAATT
GGGAATCCAAAACCCTAACTTTAGCTATTTTGGGAAGAAATCAGCCCGTACTGTCGATCTTGACAACGAACAAGC
TGTCGCTTTTACAAAAGCCCTTATCGACAAGTATGCTGCTTATTTCGCGAAAAAGACTGAAATCTTCAACATCGGA
CTTGATGAATATGCCAATGATGCGACAGATGCTAAAGGTTGGAGTGTGCTTCAAGCTGATAAATACTATCCAAAC
GAAGGCTACCCTGTAAAAGGCTATGAAAAATTTATTGCCTACGCCAATGACCTCGCTCGTATTGTAAAATCGCAC
GGTCTCAAACCAATGGCTTTTAACGACGGTATCTACTACAATAGCGACACAAGCTTTGGTAGTTTTGACAAAGAC
ATCATCGTTTCTATGTGGACTGGTGGTTGGGGAGGCTACGATGTCGCTTCTTCTAAACTACTAGCTGAAAAAGGTC
ACCAAATCCTTAATACCAATGATGCTTGGTACTACGTTCTTGGACGAAACGCTGATGGCCAAGGCTGGTACAATCT
CGATCAGGGGCTCAATGGTATTAAAAACACACCAATCACTTCTGTACCAAAAACAGAAGGAGCTGATATCCCAAT
CATCGGTGGTATGGTAGCTGCTTGGGCTGACACTCCATCTGCACGTTATTCACCATCACGCCTCTTCAAACTCATG
CGTCATTTTTGCAAATGCCAACGCTGAATACTTCGCAGCTGATTATGAATCTGCAGAGCAAGCACTTAACGAGGTA
CCAAAAGACCTGAACCGTTATACTGCAGAAAGCGTCACGGCCGTAAAAGAAGCTGAAAAAGCTATTCGCTCTCTC
GATAGCAACCTTAGCCGTGCCCAACAAGATACGATTGATCAAGCCATTGCTAAACTTCAAGAAACTGTCAACAAC
TTGACCCTCACGCCTGAAGCTCAAAAAGAAGAAGAAGCTAAACGTGAGGTTGAAAAACTTGCCAAAAACAAGGT
AATCTCAATCGATGCTGGACGCAAATACTTTACTCTGAACCAGCTCAAACGCATCGTAGACAAGGCCAGTGAGCT
CGGATATTCTGATGTCCATCTCCTTCTAGGAAATGACGGACTTCGCTTTCTACTCGATGATATGACCATTACTGCC
AACGGAAAAACCTATGCTAGTGATGACGTTAAAAAAGCTATTATCGAAGGAACTAAAGCTTACTACGACGATCCA
AACGGTACTGCACTAACACCGGCAGAAGTAACAGAGCTAATTGAATACGCTAAATCTAAGGACATCGGTCTCATC
CCAGCTATTAACAGTCCAGGTCACATGGATGCTATGCTGGTTGCCATGGAAAAATTAGGTATTAAAAATCCTCAA
GCCCACTTTGATAAAGTTTCAAAAACAACTATGGACTTGAAAAACGAAGAAGCGATGAACTTTGTAAAAAGCCCTC
ATCGGTAAATACATGGACTTCTTTGCAGGTAAAACAAAGATTTTCAACTTTGGTACTGACGAATACGCCAACGAT
GCGACTAGTGCCCAAGGCTGGTACTACCTCAAGTGGTATCAACTCTATGGCAAATTTGCCGAATATGCCAACACC
CTCCAGCTATGGCCAAAGAAAGAGGGCTTCAACCAATGGCCTTCAACGATGGCTTCTACTATGAAGACAAGGAC
GATGTTCAGTTTGACAAAGATGTCTTGATTTCTTACTGGTCTAAAGGCTGGTGGGGATATAACCTCGCATCACCTC
AATACCTAGCAAGCAAAGGCTATAAATTCTTGAATACCAACGGTGACTGGTACTACATTCTTGGTCAAAAACCAG
AAGATGGTGGTGGTTTCCTCAAGAAAGCTATTGAGAATACTGGAAAAACACCATTCAATCAACTAGCTTCTACCA
AATATCCTGAAGTAGATCTTCCAACAGTCGGAAGTATGCTTTCAATCTGGGCAGATAGACCAAGCGCTGAATACA
AGGAAGAGGAAATCTTTGAACTCATGACTGCCTTTGCAGACCACAACAAAGACTACTTTCGTGCTAATTATAATG
CTCTCCGCGAAGAATTAGCTAAAATTCCTACAAACTTAGAAGGATATAGTAAAGAAAGTCTTGAGGCCCTTGACG
CAGCTAAAACAGCTCTAAATTACAACCTCAACCGTAATAAACAAGCTGAGCTTGACACGCTTGTAGCCAACCTAA
AAGCCGCTCTTCAAGGCCTCAAACCAGCTGTAACTCATTCAGGAAGCCTCGATGAAAATGAAGTGGCTCGGAATG
TTGAAACCAGACCAGAACTCATCACAAGAACTGAAGAAATTCCATTTCAAGTTATCAAGAAAGAAAATCCTAACC
TCCCAGCCGGTCAGGAAAATATTATCACAGCAGGAGTCAAAGGTGAACGAACTCATTACATCTCTGTACTCACTG
AAAATGGAAAAACAACAGAAACAGTCCTTCATAGCCAGGTAACCAAAGAAGTTATAAACCAAGTGGTTGAAGTT
GGCGCTCCTGTAACTCAGAAGGGTGATGAAAGTGGTCTTGCACCAACTACTGAGGTAAAACCTAGACTGGATATC
CAAGAAGAAGAAATTCCATTTACCACAGTGACTTGTGAAAATCCACTCTTACTCAAAGGAAAAACACAAGTCATT
ACTAAGGGCGTCAATGGACATCGTAGCAACTTCTACTCTGTGAGCACTTCTGCCGATGGTAAGGAAGTGAAAACA
CTTGTAAATAGTGTCGTAGCACAGGAAGCCGTTACTCAAATAGTCGAAGTCGGAACTATGGTAACACATGTAGGC
GATGAAAACGGACAAGCCGCTATTGCTGAAGAAAAACCAAAACTAGAAATCCCAAGCCAACCAGCTCCATCAAC
TGCTCCTGCTGAGGAAAGCAAAGTTCTTCCTCAAGATCCAGCTCCTGTGGTAACAGAGAAAAAACTTCCTGAAAC
AGGAACTCACGATTCTGCAGGACTAGTAGTCGCAGGACTCATGTCCACACTAGCAGCCTATGGACTCACTAAAAG
AAAAGAAGACTAA

MIYILAINITMQSGGFAMKHEKQQRFSIRKYAVGAASVLIGFAFQAQTVAADGVTPTTTENQPTIHTVSDSPQSSENRTEE
TPKAVLQPEAPKTVETETPATDKVASLPKTEEKPQEEVSSTPSDKAEVVTPTSAEKETANKKAEEASPKKEEAKEVDSKE
SNTDKTDKDKPAKKDEAKAEADKPATEAGKERAATVNEKLAKKKIVSIDAGRKYFSPEQLKEIIDKAKHYGYTDLHLL
VGNDGLRFMLDDMSITANGKTYASDDVKRAIEKGTNDYYNDPNGNHLTESQMTDLINYAKDKGIGLIPTVNSPGHMD
AILNAMKELGIQNPNFSYFGKKSARTVDLDNEQAVAFTKALIDKYAAYFAKKTEIFNIGLDEYANDATDAKGWSVLQA
DKYYPNEGYPVKGYEKFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSFDKDIIVSMWTGGWGGYDVASSKLLA
EKGHQILNTNDAWYYVLGRNADGQGWYNLDQGLNGIKNTPITSVPKTEGADIPIIGGMVAAWADTPSARYSPSRLFKL
MRHFANANAEYFADADYESAEQALNEVPKDLNRYTAESVTAVKEAEKAIRSLDSNLSRAQQDTIDQAIAKLQETVNNLT
LTPEAQKEEEAKREVEKLAKNKVISIDAGRKYFTLNQLKRIVDKASELGYSDVHLLLGNDGLRFLLDDMTTTANGKTYA
SDDVKKAIIEGTKAYYDDPNGTALTQAEVTELIEYAKSKDIGLIPAINSPGHMDAMLVAMEKLGIKNPQAHFDKVSKTT
MDLKNEEAMNFVKALIGKYMDFFAGKTKIFNFGTDEYANDATSAQGWYYLKWYQLYGKFAEYANTLAAMAKERGL
QPMAFNDGFYYEDKDDVQFDKDVLISYWSKGWWGYNLASPQYLASKGYKFLNTNGDWYYILGQKPEDGGGFLKKAI
ENTGKTPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEIFELMTAFADHNKDYFRANYNALREELAKIPTNLEG
YSKESLEALDAAKTALNYNLNRNKQAELDTLVANLKAALQGLKPAVTHSGSLDENEVAANVETRPELITRTEEIPFEVI
KKENPNLPAGQENIITAGVKGERTHYISVLTENGKTTETVLDSQVTKEVINQVVEVGAPVTHKGDESGLAPTTEVKPRL
DIQEEEIPFTTVTCENPLLLKGKTQVITKGVNGHRSNFYSVSTSADGKEVKTLVNSVVAQEAVTQIVEVGTMVTHVGDE
NGQAAIAEEKPKLEIPSQPAPSTAPAEESKVLPQDPAPVVTEKKLPETGTHDSAGLVVAGLMSTLAAYGLKRKEDZ

ID122 825 bp
ATGAACAAAAAAACAAGACAGACACTAATCGGACTGCTAGTGTTATTGTTTTGTCTACAGGGAGCTATTATATC
AAGCAGATGCCGTCGGCACCTAATAGTCCCAAAACCAATCTTAGTCAGAAAAAACAAGCGTCTGAAGCTCCTAGT
CAAGCATTGGCAGAGAGTGTCTTAACAGACGCAGTCAAGAGTCAAATAAAAAAAAGTCTGGAGTGGAATGGCTC
AGGTGCTTTTATCGTCAATGGTAATAAAACAAATCTAGATGCCAAGGTTTCAAGTAAGCCCTACGCTGACAATAA
AACAAAGACAGTGGGCAAGGAAACTGTTCCAACCGTAGCTAATGCCCTCTTGTCTAAGGCCACTCGTCAGTACAA
GAATCGTAAAGAAACTGGGAATGGTTCAACTTCTTGGACTCCTCCAGGTTGGCATCAGGTCAAGAATCTAAAGGG
CTCTTACCCATGCAGTCGATAGAGGTCATTTGTTAGGCTATGCCTTAATCGGTGGTTTGGATGGTTTTGATGCCT
CAACAAGCAATCCTAAAAACATTGCTGTTCAGACAGCCTGGGCAAATCAGGCACAAGCCGAGTATTCGACTGGTC
AAAACTACTATGAAAGCAAGGTGCGTAAAGCCTTGGACCAAAACAAGCGTGTCCGTTACCGTGTAACCCTTTACT
ACGCTTCAAACGAGGATTTAGTTCCCTCAGCTTCACAGATTGAAGCCAAGTCTTCGGATGGAGAATTGGAATTCA
ATGTTCTAGTTCCCAATGTTCAAAAGGGACTTCAACTGGATTACCGAACTGGAGAAGTAACTGTAACTCAGTAA

MNKKTRQTLIGLLVLLLLSTGSYYIKQMPSAPNSPKTNLSQKKQASEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIV
NGNKTNLDAKVSSKPYADNKTKTVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAV
DRGHLLGYALIGGLDGFASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRVRYRVTLYYASNEDL
VPSASQIEAKSSDGELEFNVLVPNVQKGLQDYRTGEVTVTQZ

ID123 225 bp
GTGCTAAGATTCAGCGGATTGAGGCAAGTGATGAAGATGAATAAGAAATCAAGCTACGTAGTCAAGCGTTTACTT
TTAGTCATCATAGTACTGATTTTAGGTACTCTGGCTCTAGGAATCGGTTTAATGGTAGGTTATGGAATCTTGGGCA
AGGGTCAAGATCCATGGGCTATCCTGTCTCCAGCAAAATGGCAGGAATTGATTCATAAATTTACAGGAAATTAG

VLRFSGLRQVMKMKKSSYVVKRLLLVIIVLILGTLALGIGLMVGTYGILGKGQDPQAILSPAKWQELIHKFTGNZ

[0164]
1 196 1 1200 DNA Streptococcus pneumoniae 1 atgagaaata tgtgggttgt aatcaaggaa acctatcttc gacatgtcga gtcatggagt 60 ttcttcttta tggtgatttc gccgttcctc tttttaggaa tctctgtagg aattgggcat 120 ctccaaggtt cttctatggc taaaaataat aaagtggcag tagtgacaac agtgccatct 180 gtagcagaag gactgaagaa tgtaaatggt gttaacttcg actataaaga cgaagcaagt 240 gccaaagaag caattaaaga agaaaaatta aaaggttatt tgaccattga tcaagaagat 300 agtgttctaa aggcagttta tcatggcgaa acatcgcttg aaaatggaat taaatttgag 360 gttacaggta cactcaatga actgcaaaat cagcttaatc gttcaactgc ttccttgtct 420 caagagcagg aaaaacgctt agcgcagaca attcaattca cagaaaagat tgatgaagcc 480 aaggaaaata aaaagtttat tcaaacaatt gcagcaggtg ccttaggatt ctttctttat 540 atgattctga ttacctatgc gggtgtaaca gctcaggaag ttgccagtga aaaaggcacc 600 aaaattatgg aagtcgtttt ttctagcata agggcaagtc actatttcta tgcgcggatg 660 atggctctgt ttctagtgat tttaacgcat attgggatct atgttgtagg tggtctggct 720 gccgttttgc tctttaaaga tttgccattc ttggctcagt ctggtatttt ggatcacttg 780 ggagatgcta tctcactgaa taccttgctc tttattttga tcagtctttt catgtacgta 840 gtcttggcag ccttcctagg atctatggtt tctcgtcctg aggactcagg gaaagccttg 900 tcgcctttga tgattttgat tatgggtggt ttttttggag tgacagctct aggtgcagct 960 ggtgacaatc tcctcttgaa gattggttct tatattccct ttatttcgac cttctttatg 1020 ccgtttcgaa cgattaatga ctatgcgggg ggagcagaag catggatttc acttgctatt 1080 acagtgattt ttgcggtggt agcaacagga tttatcggac gcatgtatgc tagtctcgtt 1140 cttcaaacgg atgatttagg gatttggaaa acctttaaac gtgccttatc ttataaatag 1200 2 399 PRT Streptococcus pneumoniae 2 Met Arg Asn Met Trp Val Val Ile Lys Glu Thr Tyr Leu Arg His Val 1 5 10 15 Glu Ser Trp Ser Phe Phe Phe Met Val Ile Ser Pro Phe Leu Phe Leu 20 25 30 Gly Ile Ser Val Gly Ile Gly His Leu Gln Gly Ser Ser Met Ala Lys 35 40 45 Asn Asn Lys Val Ala Val Val Thr Thr Val Pro Ser Val Ala Glu Gly 50 55 60 Leu Lys Asn Val Asn Gly Val Asn Phe Asp Tyr Lys Asp Glu Ala Ser 65 70 75 80 Ala Lys Glu Ala Ile Lys Glu Glu Lys Leu Lys Gly Tyr Leu Thr Ile 85 90 95 Asp Gln Glu Asp Ser Val Leu Lys Ala Val Tyr His Gly Glu Thr Ser 100 105 110 Leu Glu Asn Gly Ile Lys Phe Glu Val Thr Gly Thr Leu Asn Glu Leu 115 120 125 Gln Asn Gln Leu Asn Arg Ser Thr Ala Ser Leu Ser Gln Glu Gln Glu 130 135 140 Lys Arg Leu Ala Gln Thr Ile Gln Phe Thr Glu Lys Ile Asp Glu Ala 145 150 155 160 Lys Glu Asn Lys Lys Phe Ile Gln Thr Ile Ala Ala Gly Ala Leu Gly 165 170 175 Phe Phe Leu Tyr Met Ile Leu Ile Thr Tyr Ala Gly Val Thr Ala Gln 180 185 190 Glu Val Ala Ser Glu Lys Gly Thr Lys Ile Met Glu Val Val Phe Ser 195 200 205 Ser Ile Arg Ala Ser His Tyr Phe Tyr Ala Arg Met Met Ala Leu Phe 210 215 220 Leu Val Ile Leu Thr His Ile Gly Ile Tyr Val Val Gly Gly Leu Ala 225 230 235 240 Ala Val Leu Leu Phe Lys Asp Leu Pro Phe Leu Ala Gln Ser Gly Ile 245 250 255 Leu Asp His Leu Gly Asp Ala Ile Ser Leu Asn Thr Leu Leu Phe Ile 260 265 270 Leu Ile Ser Leu Phe Met Tyr Val Val Leu Ala Ala Phe Leu Gly Ser 275 280 285 Met Val Ser Arg Pro Glu Asp Ser Gly Lys Ala Leu Ser Pro Leu Met 290 295 300 Ile Leu Ile Met Gly Gly Phe Phe Gly Val Thr Ala Leu Gly Ala Ala 305 310 315 320 Gly Asp Asn Leu Leu Leu Lys Ile Gly Ser Tyr Ile Pro Phe Ile Ser 325 330 335 Thr Phe Phe Met Pro Phe Arg Thr Ile Asn Asp Tyr Ala Gly Gly Ala 340 345 350 Glu Ala Trp Ile Ser Leu Ala Ile Thr Val Ile Phe Ala Val Val Ala 355 360 365 Thr Gly Phe Ile Gly Arg Met Tyr Ala Ser Leu Val Leu Gln Thr Asp 370 375 380 Asp Leu Gly Ile Trp Lys Thr Phe Lys Arg Ala Leu Ser Tyr Lys 385 390 395 3 1125 DNA Streptococcus pneumoniae 3 cctgggaaag tcttgaaaat tatgatagaa tggtggaagg aaaaattcag gagagtagta 60 gtgactcaaa atgttgaaag tcttctcgta tccattgtaa tcagtgcata caatgaagaa 120 aaatatctgc ctggtctaat tgaagactta aaaaatcaaa cctatcctaa agaggatatt 180 gaaattctat ttataaatgc tatgtccaca gatgggacca cagctatcat tcagcaattt 240 ataaaggaag atacagagtt taactcaatt agattgtata acaatcctaa gaaaaatcaa 300 gctagtggtt ttaacctggg agttaaacat tctgtagggg accttatttt aaaaattgat 360 gctcattcaa aagttactga gacttttgta atgaacaatg tggctattat tcaacaaggt 420 gaatttgtct gtggggggcc tagaccgacg attgtcgaag gaaaaggaaa atgggcagag 480 accttgcatc ttgttgagga aaatatgttt ggcagtagca ttgccaatta tcgaaatagt 540 tctgaggata gatatgtttc ttctattttt catggaatgt ataaacgaga ggttttccag 600 aaggttggtt tagtaaatga gcaacttggc cgaactgaag ataatgatat tcattataga 660 attcgagaat atggttataa aatccgctat agcccaagta ttctatctta tcagtatatt 720 cgaccaacat tcaagaaaat gctgcatcaa aagtattcaa atggtttgtg gattggcttg 780 acaagtcatg ttcagtttaa gtgtttatca ttatttcact atgttccttg tttatttgtt 840 ttgagtcttg tgtttagtct agcattgtta ccgatcacat tcgtattcat aactttacta 900 ttaggtgcct attttctact tttgtcatta ctcactttgc tgactttatt aaaacataaa 960 aatggatttc taattgtgat gccctttatt ttattttcca ttcactttgc ttatggcctt 1020 gggacgattg taggtttaat tagaggattt aaatggaaga aggagtacaa gagaacaata 1080 atttatttgg ataaaataag ccaaataaat caaaatatgc tataa 1125 4 374 PRT Streptococcus pneumoniae 4 Pro Gly Lys Val Leu Lys Ile Met Ile Glu Trp Trp Lys Glu Lys Phe 1 5 10 15 Arg Arg Val Val Val Thr Gln Asn Val Glu Ser Leu Leu Val Ser Ile 20 25 30 Val Ile Ser Ala Tyr Asn Glu Glu Lys Tyr Leu Pro Gly Leu Ile Glu 35 40 45 Asp Leu Lys Asn Gln Thr Tyr Pro Lys Glu Asp Ile Glu Ile Leu Phe 50 55 60 Ile Asn Ala Met Ser Thr Asp Gly Thr Thr Ala Ile Ile Gln Gln Phe 65 70 75 80 Ile Lys Glu Asp Thr Glu Phe Asn Ser Ile Arg Leu Tyr Asn Asn Pro 85 90 95 Lys Lys Asn Gln Ala Ser Gly Phe Asn Leu Gly Val Lys His Ser Val 100 105 110 Gly Asp Leu Ile Leu Lys Ile Asp Ala His Ser Lys Val Thr Glu Thr 115 120 125 Phe Val Met Asn Asn Val Ala Ile Ile Gln Gln Gly Glu Phe Val Cys 130 135 140 Gly Gly Pro Arg Pro Thr Ile Val Glu Gly Lys Gly Lys Trp Ala Glu 145 150 155 160 Thr Leu His Leu Val Glu Glu Asn Met Phe Gly Ser Ser Ile Ala Asn 165 170 175 Tyr Arg Asn Ser Ser Glu Asp Arg Tyr Val Ser Ser Ile Phe His Gly 180 185 190 Met Tyr Lys Arg Glu Val Phe Gln Lys Val Gly Leu Val Asn Glu Gln 195 200 205 Leu Gly Arg Thr Glu Asp Asn Asp Ile His Tyr Arg Ile Arg Glu Tyr 210 215 220 Gly Tyr Lys Ile Arg Tyr Ser Pro Ser Ile Leu Ser Tyr Gln Tyr Ile 225 230 235 240 Arg Pro Thr Phe Lys Lys Met Leu His Gln Lys Tyr Ser Asn Gly Leu 245 250 255 Trp Ile Gly Leu Thr Ser His Val Gln Phe Lys Cys Leu Ser Leu Phe 260 265 270 His Tyr Val Pro Cys Leu Phe Val Leu Ser Leu Val Phe Ser Leu Ala 275 280 285 Leu Leu Pro Ile Thr Phe Val Phe Ile Thr Leu Leu Leu Gly Ala Tyr 290 295 300 Phe Leu Leu Leu Ser Leu Leu Thr Leu Leu Thr Leu Leu Lys His Lys 305 310 315 320 Asn Gly Phe Leu Ile Val Met Pro Phe Ile Leu Phe Ser Ile His Phe 325 330 335 Ala Tyr Gly Leu Gly Thr Ile Val Gly Leu Ile Arg Gly Phe Lys Trp 340 345 350 Lys Lys Glu Tyr Lys Arg Thr Ile Ile Tyr Leu Asp Lys Ile Ser Gln 355 360 365 Ile Asn Gln Asn Met Leu 370 5 696 DNA Streptococcus pneumoniae 5 atgatgaaag aacaaaatac gatagaaatc gatgtatttc aattagttaa aagcttgtgg 60 aaacgcaagc taatgatttt aatagtggca cttgtgacag gtgcgggggc ttttgcatat 120 agcactttta ttgttaagcc agaatatacg agtaccacgc gaatttacgt agtgaatcgc 180 aatcaaggag acaagccggg gttgacaaat caggatttgc aggcaggaac ttatctggta 240 aaagactacc gtgagattat cctttcgcag gatgttttgg aggaagttgt ttctgatttg 300 aaactagatt tgacgccaaa aggtttggct aataaaatta aagtgacagt accagttgat 360 acccgtattg tctctatttc agttaatgat cgagttcctg aagaggcaag ccgtatcgct 420 aactctttga gagaagtagc tgctcaaaaa attatcagta ttactcgtgt ttctgacgtg 480 acaacactgg aggaggcaag gccggcgata tccccgtctt cgccaaatat taaacgcaat 540 acactaattg gttttttggc aggggtgatt ggaactagtg ttatagttct tcatcttgaa 600 cttttggata ctcgtgtgaa acgtccggaa gatatcgaaa atacattgca gatgacactt 660 ttgggagttg tgccaaactt gggtaagttg aaatag 696 6 231 PRT Streptococcus pneumoniae 6 Met Met Lys Glu Gln Asn Thr Ile Glu Ile Asp Val Phe Gln Leu Val 1 5 10 15 Lys Ser Leu Trp Lys Arg Lys Leu Met Ile Leu Ile Val Ala Leu Val 20 25 30 Thr Gly Ala Gly Ala Phe Ala Tyr Ser Thr Phe Ile Val Lys Pro Glu 35 40 45 Tyr Thr Ser Thr Thr Arg Ile Tyr Val Val Asn Arg Asn Gln Gly Asp 50 55 60 Lys Pro Gly Leu Thr Asn Gln Asp Leu Gln Ala Gly Thr Tyr Leu Val 65 70 75 80 Lys Asp Tyr Arg Glu Ile Ile Leu Ser Gln Asp Val Leu Glu Glu Val 85 90 95 Val Ser Asp Leu Lys Leu Asp Leu Thr Pro Lys Gly Leu Ala Asn Lys 100 105 110 Ile Lys Val Thr Val Pro Val Asp Thr Arg Ile Val Ser Ile Ser Val 115 120 125 Asn Asp Arg Val Pro Glu Glu Ala Ser Arg Ile Ala Asn Ser Leu Arg 130 135 140 Glu Val Ala Ala Gln Lys Ile Ile Ser Ile Thr Arg Val Ser Asp Val 145 150 155 160 Thr Thr Leu Glu Glu Ala Arg Pro Ala Ile Ser Pro Ser Ser Pro Asn 165 170 175 Ile Lys Arg Asn Thr Leu Ile Gly Phe Leu Ala Gly Val Ile Gly Thr 180 185 190 Ser Val Ile Val Leu His Leu Glu Leu Leu Asp Thr Arg Val Lys Arg 195 200 205 Pro Glu Asp Ile Glu Asn Thr Leu Gln Met Thr Leu Leu Gly Val Val 210 215 220 Pro Asn Leu Gly Lys Leu Lys 225 230 7 555 DNA Streptococcus pneumoniae 7 atggtaaaag tagcagttat attagctcag ggctttgaag aaattgaagc cttgacagtt 60 gtagatgtct tgcgtcgagc caatatcaca tgtgatatgg ttggttttga agagcaagta 120 acgggttcgc atgcaatcca agtaagagca gatcatgtct ttgatggaga tttatcagac 180 tatgatatga ttgttcttcc tggaggtatg cctggttctg cacatttacg tgataatcag 240 accttgattc aagaattgca aagcttcgag caagaaggga agaaactagc agccatttgt 300 gcggcaccaa ttgccctcaa tcaagcagag atattgaaaa ataagcgata cacttgttat 360 gacggcgttc aagagcaaat ccttgatggt cactacgtca aggaaacagt agtggtagat 420 ggtcagttga caaccagtcg gggtccttca acagcccttg cctttgccta cgagttggtg 480 gagcaactag gaggggacgc agagagttta cgaacaggaa tgctctatcg agatgtcttt 540 ggtaaaaatc agtaa 555 8 184 PRT Streptococcus pneumoniae 8 Met Val Lys Val Ala Val Ile Leu Ala Gln Gly Phe Glu Glu Ile Glu 1 5 10 15 Ala Leu Thr Val Val Asp Val Leu Arg Arg Ala Asn Ile Thr Cys Asp 20 25 30 Met Val Gly Phe Glu Glu Gln Val Thr Gly Ser His Ala Ile Gln Val 35 40 45 Arg Ala Asp His Val Phe Asp Gly Asp Leu Ser Asp Tyr Asp Met Ile 50 55 60 Val Leu Pro Gly Gly Met Pro Gly Ser Ala His Leu Arg Asp Asn Gln 65 70 75 80 Thr Leu Ile Gln Glu Leu Gln Ser Phe Glu Gln Glu Gly Lys Lys Leu 85 90 95 Ala Ala Ile Cys Ala Ala Pro Ile Ala Leu Asn Gln Ala Glu Ile Leu 100 105 110 Lys Asn Lys Arg Tyr Thr Cys Tyr Asp Gly Val Gln Glu Gln Ile Leu 115 120 125 Asp Gly His Tyr Val Lys Glu Thr Val Val Val Asp Gly Gln Leu Thr 130 135 140 Thr Ser Arg Gly Pro Ser Thr Ala Leu Ala Phe Ala Tyr Glu Leu Val 145 150 155 160 Glu Gln Leu Gly Gly Asp Ala Glu Ser Leu Arg Thr Gly Met Leu Tyr 165 170 175 Arg Asp Val Phe Gly Lys Asn Gln 180 9 306 DNA Streptococcus pneumoniae 9 gtggtaggga tggtagaacc aaacctagaa agccttataa aagatcttta caatcatgct 60 cgacatgatt tgagtgaaga tttagttgct gctctcctag agactactaa aaaactgcct 120 actacaaatg agcaattgca ggcagttcgt ctctcaggcc tggtcaatcg tgaattgctc 180 ctaaatccca aacatccagc acctgagttg ctcaacttgg ctcgctttgt caaaagagaa 240 gaagccaagt acagaggaac tgcgacttct gcgcttatgt atgaggaact ctttaaaatg 300 ctttga 306 10 101 PRT Streptococcus pneumoniae 10 Met Val Gly Met Val Glu Pro Asn Leu Glu Ser Leu Ile Lys Asp Leu 1 5 10 15 Tyr Asn His Ala Arg His Asp Leu Ser Glu Asp Leu Val Ala Ala Leu 20 25 30 Leu Glu Thr Thr Lys Lys Leu Pro Thr Thr Asn Glu Gln Leu Gln Ala 35 40 45 Val Arg Leu Ser Gly Leu Val Asn Arg Glu Leu Leu Leu Asn Pro Lys 50 55 60 His Pro Ala Pro Glu Leu Leu Asn Leu Ala Arg Phe Val Lys Arg Glu 65 70 75 80 Glu Ala Lys Tyr Arg Gly Thr Ala Thr Ser Ala Leu Met Tyr Glu Glu 85 90 95 Leu Phe Lys Met Leu 100 11 945 DNA Streptococcus pneumoniae 11 ttgttcttaa aaaaggaaag agaggtaatc agcatgcgta aatggacaaa aggatttctc 60 atctttggtg tggtgactac cgttatcggc tttatcctgc tttttgtagg tatccaatct 120 gacgggatta agagcctact ttccatgtcc aaagaacctg tctatgatag ccgtacggaa 180 aagctaacct ttggcaagga agtcgaaaac ctagaaatta ctctccacca acacacgctc 240 accatcacag actctttcga tgatcaaatc cacatttctt accatccatc tctttctgct 300 caccatgatc ttatcaccaa tcagaacgat agaactctga gtctcactga taagaaactg 360 tctgaaactc cgtttctctc ttctggaatt ggtgggattc ttcatatcgc aagtagctac 420 tctagtcgtt ttgaagaagt tattctccga ctaccaaaag ggagaactct aaaagggatc 480 aacatctcag ccaatcgcgg acaaaccacc atcataaatg ctagccttga aaatgcgacc 540 ctcaatacaa acagctatat cctccgaatt gaaggaagtc gtatcaaaaa cagtaaactc 600 acaacgccca atatcgttaa tatctttgat acagttctta cagatagtca gctagagtca 660 acagagaatc acttccacgc tgaaaatatc caagtccatg gcaaggttga actgactgcc 720 aaagattatc tcagaatcat cctagaccag aaagaaagcc aacgaattaa ctgggacatc 780 tcaagcaact atggttctat cttccaattc acaagagaaa agcctgaatc aagaggtacg 840 gaattaagca acccttacaa aactgaaaaa accgatgtca aggatcaact cattgcgaga 900 tctgatgata atattgatct aatatccaca ccaagcagac gttga 945 12 314 PRT Streptococcus pneumoniae 12 Met Phe Leu Lys Lys Glu Arg Glu Val Ile Ser Met Arg Lys Trp Thr 1 5 10 15 Lys Gly Phe Leu Ile Phe Gly Val Val Thr Thr Val Ile Gly Phe Ile 20 25 30 Leu Leu Phe Val Gly Ile Gln Ser Asp Gly Ile Lys Ser Leu Leu Ser 35 40 45 Met Ser Lys Glu Pro Val Tyr Asp Ser Arg Thr Glu Lys Leu Thr Phe 50 55 60 Gly Lys Glu Val Glu Asn Leu Glu Ile Thr Leu His Gln His Thr Leu 65 70 75 80 Thr Ile Thr Asp Ser Phe Asp Asp Gln Ile His Ile Ser Tyr His Pro 85 90 95 Ser Leu Ser Ala His His Asp Leu Ile Thr Asn Gln Asn Asp Arg Thr 100 105 110 Leu Ser Leu Thr Asp Lys Lys Leu Ser Glu Thr Pro Phe Leu Ser Ser 115 120 125 Gly Ile Gly Gly Ile Leu His Ile Ala Ser Ser Tyr Ser Ser Arg Phe 130 135 140 Glu Glu Val Ile Leu Arg Leu Pro Lys Gly Arg Thr Leu Lys Gly Ile 145 150 155 160 Asn Ile Ser Ala Asn Arg Gly Gln Thr Thr Ile Ile Asn Ala Ser Leu 165 170 175 Glu Asn Ala Thr Leu Asn Thr Asn Ser Tyr Ile Leu Arg Ile Glu Gly 180 185 190 Ser Arg Ile Lys Asn Ser Lys Leu Thr Thr Pro Asn Ile Val Asn Ile 195 200 205 Phe Asp Thr Val Leu Thr Asp Ser Gln Leu Glu Ser Thr Glu Asn His 210 215 220 Phe His Ala Glu Asn Ile Gln Val His Gly Lys Val Glu Leu Thr Ala 225 230 235 240 Lys Asp Tyr Leu Arg Ile Ile Leu Asp Gln Lys Glu Ser Gln Arg Ile 245 250 255 Asn Trp Asp Ile Ser Ser Asn Tyr Gly Ser Ile Phe Gln Phe Thr Arg 260 265 270 Glu Lys Pro Glu Ser Arg Gly Thr Glu Leu Ser Asn Pro Tyr Lys Thr 275 280 285 Glu Lys Thr Asp Val Lys Asp Gln Leu Ile Ala Arg Ser Asp Asp Asn 290 295 300 Ile Asp Leu Ile Ser Thr Pro Ser Arg Arg 305 310 13 879 DNA Streptococcus pneumoniae 13 atgaaacaag aatggtttga aagtaatgat tttgtaaaaa caacaagcaa gaacaagcct 60 gaagagcaag ctcaagaggt tgcagacaag gctgaagaaa cgatagccga tctcgataca 120 ccaattgaaa aaaatactca gttagaggag gaagtccctc aagctgaagt cgaattggaa 180 agccagcaag aagagaaaat tgaagctcct gaagacagtg aagcgagaac agaaatagaa 240 gaaaagaagg catctaattc tactgaagaa gagccagacc tttctaaaga aacagaaaaa 300 gtcactatag ctgaagagag ccaagaagct cttcctcagc aaaaagcaac cacgaaagag 360 ccacttctta tcagtaaatc tttagaaagt ccttatatcc ccgaccaagc tccaaaatct 420 agggataaat ggaaagagca agtgcttgat ttttggtctt ggctagtgga agcgatcaaa 480 tctcctacaa gtaagttgga aacaagtatc acacacagtt acacagcctt tctcttgctc 540 attctgtttt ctgcatcttc ctttttcttt agtatctatc acatcaaaca tgcttactat 600 ggacatatag caagcattaa cagtcgcttc cctgagcagc tagctccttt aactcttttt 660 tctatcatct ctatcctagt agcgacaaca ctcttcttct tttcattcct cttgggtagt 720 ttcgttgtga gacgatttat ccaccaggaa aaggactgga cgctagacaa ggttctccaa 780 caatatagtc aactcttggc aattccaatc tcctcactgc tattgctagt ttctttgctt 840 tctttgatag cctacgattt acagccctct tgtgtgtga 879 14 292 PRT Streptococcus pneumoniae 14 Met Lys Gln Glu Trp Phe Glu Ser Asn Asp Phe Val Lys Thr Thr Ser 1 5 10 15 Lys Asn Lys Pro Glu Glu Gln Ala Gln Glu Val Ala Asp Lys Ala Glu 20 25 30 Glu Thr Ile Ala Asp Leu Asp Thr Pro Ile Glu Lys Asn Thr Gln Leu 35 40 45 Glu Glu Glu Val Pro Gln Ala Glu Val Glu Leu Glu Ser Gln Gln Glu 50 55 60 Glu Lys Ile Glu Ala Pro Glu Asp Ser Glu Ala Arg Thr Glu Ile Glu 65 70 75 80 Glu Lys Lys Ala Ser Asn Ser Thr Glu Glu Glu Pro Asp Leu Ser Lys 85 90 95 Glu Thr Glu Lys Val Thr Ile Ala Glu Glu Ser Gln Glu Ala Leu Pro 100 105 110 Gln Gln Lys Ala Thr Thr Lys Glu Pro Leu Leu Ile Ser Lys Ser Leu 115 120 125 Glu Ser Pro Tyr Ile Pro Asp Gln Ala Pro Lys Ser Arg Asp Lys Trp 130 135 140 Lys Glu Gln Val Leu Asp Phe Trp Ser Trp Leu Val Glu Ala Ile Lys 145 150 155 160 Ser Pro Thr Ser Lys Leu Glu Thr Ser Ile Thr His Ser Tyr Thr Ala 165 170 175 Phe Leu Leu Leu Ile Leu Phe Ser Ala Ser Ser Phe Phe Phe Ser Ile 180 185 190 Tyr His Ile Lys His Ala Tyr Tyr Gly His Ile Ala Ser Ile Asn Ser 195 200 205 Arg Phe Pro Glu Gln Leu Ala Pro Leu Thr Leu Phe Ser Ile Ile Ser 210 215 220 Ile Leu Val Ala Thr Thr Leu Phe Phe Phe Ser Phe Leu Leu Gly Ser 225 230 235 240 Phe Val Val Arg Arg Phe Ile His Gln Glu Lys Asp Trp Thr Leu Asp 245 250 255 Lys Val Leu Gln Gln Tyr Ser Gln Leu Leu Ala Ile Pro Ile Ser Ser 260 265 270 Leu Leu Leu Leu Val Ser Leu Leu Ser Leu Ile Ala Tyr Asp Leu Gln 275 280 285 Pro Ser Cys Val 290 15 990 DNA Streptococcus pneumoniae 15 atgcaactcg cttcttcggt ctactcattg ttcgtctggt acaatttgtt cttaaaaaag 60 gaaagagagg taatcagcat gcgtaaatgg acaaaaggat ttctcatctt tggtgtggtg 120 actaccgtta tcggctttat cctgcttttt gtaggtatcc aatctgacgg gattaagagc 180 ctactttcca tgtccaaaga acctgtctat gatagccgta cggaaaagct aacctttggc 240 aaggaagtcg aaaacctaga aattactctc caccaacaca cgctcaccat cacagactct 300 ttcgatgatc aaatccacat ttcttaccat ccatctcttt ctgctcacca tgatcttatc 360 accaatcaga acgatagaac tctgagtctc actgataaga aactgtctga aactccgttt 420 ctctcttctg gaattggtgg gattcttcat atcgcaagta gctactctag tcgttttgaa 480 gaagttattc tccgactacc aaaagggaga actctaaaag ggatcaacat ctcagccaat 540 cgcggacaaa ccaccatcat aaatgctagc cttgaaaatg cgaccctcaa tacaaacagc 600 tatatcctcc gaattgaagg aagtcgtatc aaaaacagta aactcacaac gcccaatatc 660 gttaatatct ttgatacagt tcttacagat agtcagctag agtcaacaga gaatcacttc 720 cacgctgaaa atatccaagt ccatggcaag gttgaactga ctgccaaaga ttatctcaga 780 atcatcctag accagaaaga aagccaacga attaactggg acatctcaag caactatggt 840 tctatcttcc aattcacaag agaaaagcct gaatcaagag gtacggaatt aagcaaccct 900 tacaaaactg aaaaaaccga tgtcaaggat caactcattg cgagatctga tgataatatt 960 gatctaatat ccacaccaag cagacgttga 990 16 329 PRT Streptococcus pneumoniae 16 Met Gln Leu Ala Ser Ser Val Tyr Ser Leu Phe Val Trp Tyr Asn Leu 1 5 10 15 Phe Leu Lys Lys Glu Arg Glu Val Ile Ser Met Arg Lys Trp Thr Lys 20 25 30 Gly Phe Leu Ile Phe Gly Val Val Thr Thr Val Ile Gly Phe Ile Leu 35 40 45 Leu Phe Val Gly Ile Gln Ser Asp Gly Ile Lys Ser Leu Leu Ser Met 50 55 60 Ser Lys Glu Pro Val Tyr Asp Ser Arg Thr Glu Lys Leu Thr Phe Gly 65 70 75 80 Lys Glu Val Glu Asn Leu Glu Ile Thr Leu His Gln His Thr Leu Thr 85 90 95 Ile Thr Asp Ser Phe Asp Asp Gln Ile His Ile Ser Tyr His Pro Ser 100 105 110 Leu Ser Ala His His Asp Leu Ile Thr Asn Gln Asn Asp Arg Thr Leu 115 120 125 Ser Leu Thr Asp Lys Lys Leu Ser Glu Thr Pro Phe Leu Ser Ser Gly 130 135 140 Ile Gly Gly Ile Leu His Ile Ala Ser Ser Tyr Ser Ser Arg Phe Glu 145 150 155 160 Glu Val Ile Leu Arg Leu Pro Lys Gly Arg Thr Leu Lys Gly Ile Asn 165 170 175 Ile Ser Ala Asn Arg Gly Gln Thr Thr Ile Ile Asn Ala Ser Leu Glu 180 185 190 Asn Ala Thr Leu Asn Thr Asn Ser Tyr Ile Leu Arg Ile Glu Gly Ser 195 200 205 Arg Ile Lys Asn Ser Lys Leu Thr Thr Pro Asn Ile Val Asn Ile Phe 210 215 220 Asp Thr Val Leu Thr Asp Ser Gln Leu Glu Ser Thr Glu Asn His Phe 225 230 235 240 His Ala Glu Asn Ile Gln Val His Gly Lys Val Glu Leu Thr Ala Lys 245 250 255 Asp Tyr Leu Arg Ile Ile Leu Asp Gln Lys Glu Ser Gln Arg Ile Asn 260 265 270 Trp Asp Ile Ser Ser Asn Tyr Gly Ser Ile Phe Gln Phe Thr Arg Glu 275 280 285 Lys Pro Glu Ser Arg Gly Thr Glu Leu Ser Asn Pro Tyr Lys Thr Glu 290 295 300 Lys Thr Asp Val Lys Asp Gln Leu Ile Ala Arg Ser Asp Asp Asn Ile 305 310 315 320 Asp Leu Ile Ser Thr Pro Ser Arg Arg 325 17 79 DNA Streptococcus pneumoniae 17 atgatatgta aaatgaagca gggagggagc agggcgtgct ggggatggag agtgggggag 60 ggacgctgct attttaatc 79 18 26 PRT Streptococcus pneumoniae 18 Met Ile Cys Lys Met Lys Gln Gly Gly Ser Arg Ala Cys Trp Gly Trp 1 5 10 15 Arg Val Gly Glu Gly Arg Cys Tyr Phe Asn 20 25 19 715 DNA Streptococcus pneumoniae 19 cgataaagag gccttgagta atctcaattt gcagattgaa aatggagaga ttatgggctt 60 gattggtcat aatggggctg gaaaatcgac cactataaaa tccctagtca gtatcatttc 120 acccagcagt ggtcgtattt tggtagacgg tcaggagtta tcggaaaatc gcttggctat 180 taaacgaaag attggctacg tagcagactc gcctgactta tttttacgct taacggccaa 240 tgaattttgg gaattgatcg cctcatccta tgatctgagt agatctgact tggaggctag 300 tctagctagg ctattgaacg tttttgattt tgctgaaaat cgctatcagg ttattgaaac 360 tctttctcac ggaatgcgtc agaaagtctt tgtcatcgga gcactcttgt ctgatcccga 420 tatttgggtt ttggacgaac ccttgactgg tttggatccc caggctgcct ttgatttgaa 480 acagatgatg aaggaacatg cacaaaaagg gaagacagtc ttgttttcaa ctcatgtcct 540 agaggtggca gagcaagtct gtgatcggat tgccattttg aaaaaggggc atttgattta 600 ttgtggtaag gtagaggact tgaggaaaga ccacccagac cagtctttgg aaagtatcta 660 ccttagtctt gctggtagaa aagaggaggt tgcggatgcg tctcaaggtc attaa 715 20 237 PRT Streptococcus pneumoniae 20 Asp Lys Glu Ala Leu Ser Asn Leu Asn Leu Gln Ile Glu Asn Gly Glu 1 5 10 15 Ile Met Gly Leu Ile Gly His Asn Gly Ala Gly Lys Ser Thr Thr Ile 20 25 30 Lys Ser Leu Val Ser Ile Ile Ser Pro Ser Ser Gly Arg Ile Leu Val 35 40 45 Asp Gly Gln Glu Leu Ser Glu Asn Arg Leu Ala Ile Lys Arg Lys Ile 50 55 60 Gly Tyr Val Ala Asp Ser Pro Asp Leu Phe Leu Arg Leu Thr Ala Asn 65 70 75 80 Glu Phe Trp Glu Leu Ile Ala Ser Ser Tyr Asp Leu Ser Arg Ser Asp 85 90 95 Leu Glu Ala Ser Leu Ala Arg Leu Leu Asn Val Phe Asp Phe Ala Glu 100 105 110 Asn Arg Tyr Gln Val Ile Glu Thr Leu Ser His Gly Met Arg Gln Lys 115 120 125 Val Phe Val Ile Gly Ala Leu Leu Ser Asp Pro Asp Ile Trp Val Leu 130 135 140 Asp Glu Pro Leu Thr Gly Leu Asp Pro Gln Ala Ala Phe Asp Leu Lys 145 150 155 160 Gln Met Met Lys Glu His Ala Gln Lys Gly Lys Thr Val Leu Phe Ser 165 170 175 Thr His Val Leu Glu Val Ala Glu Gln Val Cys Asp Arg Ile Ala Ile 180 185 190 Leu Lys Lys Gly His Leu Ile Tyr Cys Gly Lys Val Glu Asp Leu Arg 195 200 205 Lys Asp His Pro Asp Gln Ser Leu Glu Ser Ile Tyr Leu Ser Leu Ala 210 215 220 Gly Arg Lys Glu Glu Val Ala Asp Ala Ser Gln Gly His 225 230 235 21 360 DNA Streptococcus pneumoniae 21 atggctttgt tttcagagag aggagcagta cggaagacac caatggcaag tccaataatg 60 agacctatga tggttccgac gatagagatt aaaagagtga taccagcacc acgcaagagt 120 tgttgccagt tttcagaaag aattttagca acttggctaa agaaactact gctagtctct 180 tcagttgttg tagcttcggc aggttgttcc ttgatcatac gatccatcaa ggcaacttgg 240 tcatcttttg aaatggtttc aatgctggca ttgatttggc taatacgatt gtcattttta 300 cgaagcccga tagcgatagc tgtatcttct tccccagttt tgaaaccagg ttctacttga 360 22 119 PRT Streptococcus pneumoniae 22 Met Ala Leu Phe Ser Glu Arg Gly Ala Val Arg Lys Thr Pro Met Ala 1 5 10 15 Ser Pro Ile Met Arg Pro Met Met Val Pro Thr Ile Glu Ile Lys Arg 20 25 30 Val Ile Pro Ala Pro Arg Lys Ser Cys Cys Gln Phe Ser Glu Arg Ile 35 40 45 Leu Ala Thr Trp Leu Lys Lys Leu Leu Leu Val Ser Ser Val Val Val 50 55 60 Ala Ser Ala Gly Cys Ser Leu Ile Ile Arg Ser Ile Lys Ala Thr Trp 65 70 75 80 Ser Ser Phe Glu Met Val Ser Met Leu Ala Leu Ile Trp Leu Ile Arg 85 90 95 Leu Ser Phe Leu Arg Ser Pro Ile Ala Ile Ala Val Ser Ser Ser Pro 100 105 110 Val Leu Lys Pro Gly Ser Thr 115 23 1455 DNA Streptococcus pneumoniae 23 atgaaattta gtaaaaaata tatagcagct ggatcagctg ttatcgtatc cttgagtcta 60 tgtgcctatg cactaaacca gcatcgttcg caggaaaata aggacaataa tcgtgtctct 120 tatgtggatg gcagccagtc aagtcagaaa agtgaaaact tgacaccaga ccaggttagc 180 cagaaagaag gaattcaggc tgagcaaatt gtaatcaaaa ttacagatca gggctatgta 240 acgtcacacg gtgaccacta tcattactat aatgggaaag ttccttatga tgccctcttt 300 agtgaagaac tcttgatgaa ggatccaaac tatcaactta aagacgctga tattgtcaat 360 gaagtcaagg gtggttatat catcaaggtc gatggaaaat attatgtcta cctgaaagat 420 gcagctcatg ctgataatgt tcgaactaaa gatgaaatca atcgtcaaaa acaagaacat 480 gtcaaagata atgagaaggt taactctaat gttgctgtag caaggtctca gggacgatat 540 acgacaaatg atggttatgt ctttaatcca gctgatatta tcgaagatac gggtaatgct 600 tatatcgttc ctcatggagg tcactatcac tacattccca aaagcgattt atctgctagt 660 gaattagcag cagctaaagc acatctggct ggaaaaaata tgcaaccgag tcagttaagc 720 tattcttcaa cagctagtga caataacacg caatctgtag caaaaggatc aactagcaag 780 ccagcaaata aatctgaaaa tctccagagt cttttgaagg aactctatga ttcacctagc 840 gcccaacgtt acagtgaatc agatggcctg gtctttgacc ctgctaagat tatcagtcgt 900 acaccaaatg gagttgcgat tccgcatggc gaccattacc actttattcc ttacagcaag 960 ctttctgcct tagaagaaaa gattgccaga atggtgccta tcagtggaac tggttctaca 1020 gtttctacaa atgcaaaacc taatgaagta gtgtctagtc taggcagtct ttcaagcaat 1080 ccttcttctt taacgacaag taaggagctc tcttcagcat ctgatggtta tatttttaat 1140 ccaaaagata tcgttgaaga aacggctaca gcttatattg taagacatgg tgatcatttc 1200 cattacattc caaaatcaaa tcaaattggg caaccgactc ttccaaacaa tagtctagca 1260 acaccttctc catctcttcc aatcaatcca ggaacttcac atgagaaaca tgaagaagat 1320 ggatacggat ttgatgctaa tcgtattatc gctgaagatg aatcaggttt tgtcatgagt 1380 cacggagacc acaatcatta tttcttcaag aaggacttga cagaagagca aattaaggtg 1440 cgcaaaaaca tttag 1455 24 484 PRT Streptococcus pneumoniae 24 Met Lys Phe Ser Lys Lys Tyr Ile Ala Ala Gly Ser Ala Val Ile Val 1 5 10 15 Ser Leu Ser Leu Cys Ala Tyr Ala Leu Asn Gln His Arg Ser Gln Glu 20 25 30 Asn Lys Asp Asn Asn Arg Val Ser Tyr Val Asp Gly Ser Gln Ser Ser 35 40 45 Gln Lys Ser Glu Asn Leu Thr Pro Asp Gln Val Ser Gln Lys Glu Gly 50 55 60 Ile Gln Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 65 70 75 80 Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 85 90 95 Asp Ala Leu Phe Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 100 105 110 Leu Lys Asp Ala Asp Ile Val Asn Glu Val Lys Gly Gly Tyr Ile Ile 115 120 125 Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 130 135 140 Asp Asn Val Arg Thr Lys Asp Glu Ile Asn Arg Gln Lys Gln Glu His 145 150 155 160 Val Lys Asp Asn Glu Lys Val Asn Ser Asn Val Ala Val Ala Arg Ser 165 170 175 Gln Gly Arg Tyr Thr Thr Asn Asp Gly Tyr Val Phe Asn Pro Ala Asp 180 185 190 Ile Ile Glu Asp Thr Gly Asn Ala Tyr Ile Val Pro His Gly Gly His 195 200 205 Tyr His Tyr Ile Pro Lys Ser Asp Leu Ser Ala Ser Glu Leu Ala Ala 210 215 220 Ala Lys Ala His Leu Ala Gly Lys Asn Met Gln Pro Ser Gln Leu Ser 225 230 235 240 Tyr Ser Ser Thr Ala Ser Asp Asn Asn Thr Gln Ser Val Ala Lys Gly 245 250 255 Ser Thr Ser Lys Pro Ala Asn Lys Ser Glu Asn Leu Gln Ser Leu Leu 260 265 270 Lys Glu Leu Tyr Asp Ser Pro Ser Ala Gln Arg Tyr Ser Glu Ser Asp 275 280 285 Gly Leu Val Phe Asp Pro Ala Lys Ile Ile Ser Arg Thr Pro Asn Gly 290 295 300 Val Ala Ile Pro His Gly Asp His Tyr His Phe Ile Pro Tyr Ser Lys 305 310 315 320 Leu Ser Ala Leu Glu Glu Lys Ile Ala Arg Met Val Pro Ile Ser Gly 325 330 335 Thr Gly Ser Thr Val Ser Thr Asn Ala Lys Pro Asn Glu Val Val Ser 340 345 350 Ser Leu Gly Ser Leu Ser Ser Asn Pro Ser Ser Leu Thr Thr Ser Lys 355 360 365 Glu Leu Ser Ser Ala Ser Asp Gly Tyr Ile Phe Asn Pro Lys Asp Ile 370 375 380 Val Glu Glu Thr Ala Thr Ala Tyr Ile Val Arg His Gly Asp His Phe 385 390 395 400 His Tyr Ile Pro Lys Ser Asn Gln Ile Gly Gln Pro Thr Leu Pro Asn 405 410 415 Asn Ser Leu Ala Thr Pro Ser Pro Ser Leu Pro Ile Asn Pro Gly Thr 420 425 430 Ser His Glu Lys His Glu Glu Asp Gly Tyr Gly Phe Asp Ala Asn Arg 435 440 445 Ile Ile Ala Glu Asp Glu Ser Gly Phe Val Met Ser His Gly Asp His 450 455 460 Asn His Tyr Phe Phe Lys Lys Asp Leu Thr Glu Glu Gln Ile Lys Val 465 470 475 480 Arg Lys Asn Ile 25 840 DNA Streptococcus pneumoniae 25 atgggaattg ctctagaaaa tgtgaatttt acatatcaag aaggtactcc cttagcttca 60 gcagctttgt cggatgtttc tttgacgatt gaagatggct cttatacagc tttaattggg 120 cacacaggta gtggtaaatc aactatttta caactcttaa atggtttatt ggtgccaagt 180 caagggagtg tgagggtttt tgatacctta atcacctcga cttctaaaaa taaagatatt 240 cgtcaaatta gaaaacaggt tggcttggta tttcagtttg ctgaaaatca gatttttgaa 300 gaaacggttt tgaaggacgt tgcttttgga ccgcaaaatt ttggagtttc tgaagaagat 360 gctgtgaaga ctgcgcgtga gaaactggct ctggttggaa ttgatgaatc actttttgat 420 cgtagtccgt ttgagctgtc agggggacaa atgagacgtg ttgccattgc aggcatactt 480 gccatggagc cagctatatt agtcttagat gagccaacag ctggtctaga tcctctaggg 540 agaaaagagt tgatgaccct gttcaaaaaa ctccaccagt cagggatgac catcgtcttg 600 gtaacgcatt tgatggatga tgttgctgaa tatgcgaatc aagtctatgt aatggaaaag 660 ggacgtttag taaagggggg caaaccaagt gatgtctttc aagacgttgt ttttatggaa 720 gaagttcagt tgggagtacc taaaattacg gccttttgta aacgattggc tgatagaggc 780 gtgtcattta aacgattacc gattaagata gaggagttca aggagtcgct aaatggatag 840 26 279 PRT Streptococcus pneumoniae 26 Met Gly Ile Ala Leu Glu Asn Val Asn Phe Thr Tyr Gln Glu Gly Thr 1 5 10 15 Pro Leu Ala Ser Ala Ala Leu Ser Asp Val Ser Leu Thr Ile Glu Asp 20 25 30 Gly Ser Tyr Thr Ala Leu Ile Gly His Thr Gly Ser Gly Lys Ser Thr 35 40 45 Ile Leu Gln Leu Leu Asn Gly Leu Leu Val Pro Ser Gln Gly Ser Val 50 55 60 Arg Val Phe Asp Thr Leu Ile Thr Ser Thr Ser Lys Asn Lys Asp Ile 65 70 75 80 Arg Gln Ile Arg Lys Gln Val Gly Leu Val Phe Gln Phe Ala Glu Asn 85 90 95 Gln Ile Phe Glu Glu Thr Val Leu Lys Asp Val Ala Phe Gly Pro Gln 100 105 110 Asn Phe Gly Val Ser Glu Glu Asp Ala Val Lys Thr Ala Arg Glu Lys 115 120 125 Leu Ala Leu Val Gly Ile Asp Glu Ser Leu Phe Asp Arg Ser Pro Phe 130 135 140 Glu Leu Ser Gly Gly Gln Met Arg Arg Val Ala Ile Ala Gly Ile Leu 145 150 155 160 Ala Met Glu Pro Ala Ile Leu Val Leu Asp Glu Pro Thr Ala Gly Leu 165 170 175 Asp Pro Leu Gly Arg Lys Glu Leu Met Thr Leu Phe Lys Lys Leu His 180 185 190 Gln Ser Gly Met Thr Ile Val Leu Val Thr His Leu Met Asp Asp Val 195 200 205 Ala Glu Tyr Ala Asn Gln Val Tyr Val Met Glu Lys Gly Arg Leu Val 210 215 220 Lys Gly Gly Lys Pro Ser Asp Val Phe Gln Asp Val Val Phe Met Glu 225 230 235 240 Glu Val Gln Leu Gly Val Pro Lys Ile Thr Ala Phe Cys Lys Arg Leu 245 250 255 Ala Asp Arg Gly Val Ser Phe Lys Arg Leu Pro Ile Lys Ile Glu Glu 260 265 270 Phe Lys Glu Ser Leu Asn Gly 275 27 6360 DNA Streptococcus pneumoniae 27 tacccggtag tcttagcaga cacatctagc tctgaagatg ctttaaacat ctctgataaa 60 gaaaaagtag cagaaaataa agagaaacat gaaaatatcc atagtgctat ggaaacttca 120 caggatttta aagagaagaa aacagcagtc attaaggaaa aagaagttgt tagtaaaaat 180 cctgtgatag acaataacac tagcaatgaa gaagcaaaaa tcaaagaaga aaattccaat 240 aaatcccaag gagattatac ggactcattt gtgaataaaa acacagaaaa tcccaaaaaa 300 gaagataaag ttgtctatat tgctgaattt aaagataaag aatctggaga aaaagcaatc 360 aaggaactat ccagtcttaa gaatacaaaa gttttatata cttatgatag aatttttaac 420 ggtagtgcca tagaaacaac tccagataac ttggacaaaa ttaaacaaat agaaggtatt 480 tcatcggttg aaagggcaca aaaagtccaa cccatgatga atcatgccag aaaggaaatt 540 ggagttgagg aagctattga ttacctaaag tctatcaatg ctccgtttgg gaaaaatttt 600 gatggtagag gtatggtcat ttcaaatatc gatactggaa cagattatag acataaggct 660 atgagaatcg atgatgatgc caaagcctca atgagattta aaaaagaaga cttaaaaggc 720 actgataaaa attattggtt gagtgataaa atccctcatg cgttcaatta ttataatggt 780 ggcaaaatca ctgtagaaaa atatgatgat ggaagggatt attttgaccc acatgggatg 840 catattgcag ggattcttgc tggaaatgat actgaacaag acatcaaaaa ctttaacggc 900 atagatggaa ttgcacctaa tgcacaaatt ttctcttaca aaatgtattc tgacgcagga 960 tctgggtttg cgggtgatga aacaatgttt catgctattg aagattctat caaacacaac 1020 gttgatgttg tttcggtatc atctggtttt acaggaacag gtcttgtagg tgagaaatat 1080 tggcaagcta ttcgggcatt aagaaaagca ggcattccaa tggttgtcgc tacgggtaac 1140 tatgcgactt ctgcttcaag ttcttcatgg gatttagtag caaataatca tctgaaaatg 1200 accgacactg gaaatgtaac acgaactgca gcacatgaag atgcgatagc ggtcgcttct 1260 gctaaaaatc aaacagttga gtttgataaa gttaacatag gtggagaaag ttttaaatac 1320 agaaatatag gggccttttt cgataagagt aaaatcacaa caaatgaaga tggaacaaaa 1380 gctcctagta aattaaaatt tgtatatata ggcaaggggc aagaccaaga tttgataggt 1440 ttggatctta ggggcaaaat tgcagtaatg gatagaattt atacaaagga tttaaaaaat 1500 gcttttaaaa aagctatgga taagggtgca cgcgccatta tggttgtaaa tactgtaaat 1560 tactacaata gagataattg gacagagctt ccagctatgg gatatgaagc ggatgaaggt 1620 actaaaagtc aagtgttttc aatttcagga gatgatggtg taaagctatg gaacatgatt 1680 aatcctgata aaaaaactga agtcaaaaga aataataaag aagattttaa agataaattg 1740 gagcaatact atccaattga tatggaaagt tttaattcca acaaaccgaa tgtaggtgac 1800 gaaaaagaga ttgactttaa gtttgcacct gacacagaca aagaactcta taaagaagat 1860 atcatcgttc cagcaggatc tacatcttgg gggccaagaa tagatttact tttaaaaccc 1920 gatgtttcag cacctggtaa aaatattaaa tccacgctta atgttattaa tggcaaatca 1980 acttatggct atatgtcagg aactagtatg gcgactccaa tcgtggcagc ttctactgtt 2040 ttgattagac cgaaattaaa ggaaatgctt gaaagacctg tattgaaaaa tcttaaggga 2100 gatgacaaaa tagatcttac aagtcttaca aaaattgccc tacaaaatac tgcgcgacct 2160 atgatggatg caacttcttg gaaagaaaaa agtcaatact ttgcatcacc tagacaacag 2220 ggagcaggcc taattaatgt ggccaatgct ttgagaaatg aagttgtagc aactttcaaa 2280 aacactgatt ctaaaggttt ggtaaactca tatggttcca tttctcttaa agaaataaaa 2340 ggtgataaaa aatactttac aatcaagctt cacaatacat caaacagacc tttgactttt 2400 aaagtttcag catcagcgat aactacagat tctctaactg acagattaaa acttgatgaa 2460 acatataaag atgaaaaatc tccagatggt aagcaaattg ttccagaaat tcacccagaa 2520 aaagtcaaag gagcaaatat cacatttgag catgatactt tcactatagg cgcaaattct 2580 agctttgatt tgaatgcggt tataaatgtt ggagaggcca aaaacaaaaa taaatttgta 2640 gaatcattta ttcattttga gtcagtggaa gcgatggaag ctctaaactc cagcgggaag 2700 aaaataaact tccaaccttc tttgtcgatg cctctaatgg gatttgctgg gaattggaac 2760 cacgaaccaa tccttgataa atgggcttgg gaagaagggt caagatcaaa aacactggga 2820 ggttatgatg atgatggtaa accgaaaatt ccaggaacct taaataaggg aattggtgga 2880 gaacatggta tagataaatt taatccagca ggagttatac aaaatagaaa agataaaaat 2940 acaacatccc tggatcaaaa tccagaatta tttgctttca ataacgaagg gatcaacgct 3000 ccatcatcaa gtggttctaa gattgctaac atttatcctt tagattcaaa tggaaatcct 3060 caagatgctc aacttgaaag aggattaaca ccttctccac ttgtattaag aagtgcagaa 3120 gaaggattga tttcaatagt aaatacaaat aaagagggag aaaatcaaag agacttaaaa 3180 gtcatttcga gagaacactt tattagagga attttaaatt ctaaaagcaa tgatgcaaag 3240 ggaatcaaat catctaaact aaaagtttgg ggtgacttga agtgggatgg actcatctat 3300 aatcctagag gtagagaaga aaatgcacca gaaagtaagg ataatcaaga tcctgctact 3360 aagataagag gtcaatttga accgattgcg gaaggtcaat atttctataa atttaaatat 3420 agattaacta aagattaccc atggcaggtt tcctatattc ctgtaaaaat tgataacacc 3480 gcccctaaga ttgtttcggt tgatttttca aatcctgaaa aaattaagtt gattacaaag 3540 gatacttatc ataaggtaaa agatcagtat aagaatgaaa cgctatttgc gagagatcaa 3600 aaagaacatc ctgaaaaatt tgacgagatt gcgaacgaag tttggtatgc tggcgccgct 3660 cttgttaatg aagatggaga ggttgaaaaa aatcttgaag taacttacgc aggtgagggt 3720 caaggaagaa atagaaaact tgataaagac ggaaatacca tttatgaaat taaaggtgcg 3780 ggagatttaa ggggaaaaat cattgaagtc attgcattag atggttctag caatttcaca 3840 aagattcata gaattaaatt tgctaatcag gctgatgaaa aggggatgat ttcctattat 3900 ctagtagatc ctgatcaaga ttcatctaaa tatcaaaagc ttggcgagat tgcagaatct 3960 aaatttaaaa atttaggaaa tggaaaagag ggtagtctaa aaaaagatac aactggggta 4020 gaacatcatc atcaagaaaa tgaagagtct attaaagaaa aatctagttt tactattgat 4080 agaaatattt caacaattag agactttgaa aataaagact taaagaaact cattaaaaag 4140 aaatttagag aagttgatga ttttacaagt gaaactggta agagaatgga ggaatacgat 4200 tataaatacg atgataaagg aaatataata gcctacgatg atgggactga tctagaatat 4260 gaaactgaga aacttgacga aatcaaatca aaaatttatg gtgttctaag tccgtctaaa 4320 gatggacact ttgaaattct tggaaagata agtaatgttt ctaaaaatgc caaggtatat 4380 tatgggaata actataaatc tatagaaatc aaagcgacca agtatgattt ccactcaaaa 4440 acgatgacat ttgatctata cgctaatatt aatgatattg tggatggatt agcttttgca 4500 ggagatatga gattatttgt taaagataat gatcagaaaa aagctgaaat taaaattaga 4560 atgcctgaaa aaattaagga aactaaatca gaatatccct atgtatcaag ttatgggaat 4620 gtcatagaat taggggaagg agatctttca aaaaacaaac cagacaattt aactaaaatg 4680 gaatctggta aaatctattc tgattcagaa aaacaacaat atctgttaaa ggataatatc 4740 attctaagaa aaggctatgc actaaaagtg actacctata atcctggaaa aacggatatg 4800 ttagaaggaa atggagtcta tagcaaggaa gatatagcaa aaatacaaaa ggccaatcct 4860 aatctaagag ccctttcaga aacaacaatt tatgctgata gtagaaatgt tgaagatgga 4920 agaagtaccc aatctgtatt aatgtcggct ttggacggct ttaacattat aaggtatcaa 4980 gtgtttacat ttaaaatgaa cgataaaggg gaagctatcg ataaagacgg aaatcttgtg 5040 acagattctt ctaaacttgt attatttggt aaggatgata aagaatacac tggagaggat 5100 aagttcaatg tagaagctat aaaagaagat ggctccatgt tatttattga taccaaacca 5160 gtaaaccttt caatggataa gaactacttt aatccatcta aatctaataa aatttatgta 5220 cgaaatccag aattttattt aagaggtaag atttctgata agggtggttt taactgggaa 5280 ttgagagtta atgaatcggt tgtagataat tatttaatct acggagattt acacattgat 5340 aacactagag attttaatat taagctgaat gttaaagacg gtgacatcat ggactgggga 5400 atgaaagact ataaagcaaa cggatttcca gataaggtaa cagatatgga tggaaatgtt 5460 tatcttcaaa ctggctatag cgatttgaat gctaaagcag ttggagtcca ctatcagttt 5520 ttatatgata atgttaaacc cgaagtaaac attgatccta agggaaatac tagtatcgaa 5580 tatgctgatg gaaaatctgt agtctttaac atcaatgata aaagaaataa tggattcgat 5640 ggtgagattc aagaacaaca tatttatata aatggaaaag aatatacatc atttaatgat 5700 attaaacaaa taatagacaa gacactaaac attaagattg ttgtaaaaga ttttgcaaga 5760 aatacaaccg taaaagaatt cattttaaat aaagatacgg gagaggtaag tgaattaaaa 5820 cctcataggg taactgtgac cattcaaaat ggaaaagaaa tgagttcaac gatagtgtcg 5880 gaagaagatt ttattttacc tgtttataag ggtgaattag aaaaaggata ccaatttgat 5940 ggttgggaaa tttctggttt cgaaggtaaa aaagacgctg gctatgttat taatctatca 6000 aaagatacct ttataaaacc tgtattcaag aaaatagagg agaaaaagga ggaagaaaat 6060 aaacctactt ttgatgtatc gaaaaagaaa gataacccac aagtaaacca tagtcaatta 6120 aatgaaagtc acagaaaaga ggatttacaa agagaagagc attcacaaaa atctgattca 6180 actaaggatg ttacagctac agttcttgat aaaaacaata tcagtagtaa atcaactact 6240 aacaatccta ataagttgcc aaaaactgga acagcaagcg gagcccagac actattagct 6300 gccggaataa tgtttatagt aggaattttt cttggattga agaaaaaaaa tcaagattaa 6360 28 2119 PRT Streptococcus pneumoniae 28 Tyr Pro Val Val Leu Ala Asp Thr Ser Ser Ser Glu Asp Ala Leu Asn 1 5 10 15 Ile Ser Asp Lys Glu Lys Val Ala Glu Asn Lys Glu Lys His Glu Asn 20 25 30 Ile His Ser Ala Met Glu Thr Ser Gln Asp Phe Lys Glu Lys Lys Thr 35 40 45 Ala Val Ile Lys Glu Lys Glu Val Val Ser Lys Asn Pro Val Ile Asp 50 55 60 Asn Asn Thr Ser Asn Glu Glu Ala Lys Ile Lys Glu Glu Asn Ser Asn 65 70 75 80 Lys Ser Gln Gly Asp Tyr Thr Asp Ser Phe Val Asn Lys Asn Thr Glu 85 90 95 Asn Pro Lys Lys Glu Asp Lys Val Val Tyr Ile Ala Glu Phe Lys Asp 100 105 110 Lys Glu Ser Gly Glu Lys Ala Ile Lys Glu Leu Ser Ser Leu Lys Asn 115 120 125 Thr Lys Val Leu Tyr Thr Tyr Asp Arg Ile Phe Asn Gly Ser Ala Ile 130 135 140 Glu Thr Thr Pro Asp Asn Leu Asp Lys Ile Lys Gln Ile Glu Gly Ile 145 150 155 160 Ser Ser Val Glu Arg Ala Gln Lys Val Gln Pro Met Met Asn His Ala 165 170 175 Arg Lys Glu Ile Gly Val Glu Glu Ala Ile Asp Tyr Leu Lys Ser Ile 180 185 190 Asn Ala Pro Phe Gly Lys Asn Phe Asp Gly Arg Gly Met Val Ile Ser 195 200 205 Asn Ile Asp Thr Gly Thr Asp Tyr Arg His Lys Ala Met Arg Ile Asp 210 215 220 Asp Asp Ala Lys Ala Ser Met Arg Phe Lys Lys Glu Asp Leu Lys Gly 225 230 235 240 Thr Asp Lys Asn Tyr Trp Leu Ser Asp Lys Ile Pro His Ala Phe Asn 245 250 255 Tyr Tyr Asn Gly Gly Lys Ile Thr Val Glu Lys Tyr Asp Asp Gly Arg 260 265 270 Asp Tyr Phe Asp Pro His Gly Met His Ile Ala Gly Ile Leu Ala Gly 275 280 285 Asn Asp Thr Glu Gln Asp Ile Lys Asn Phe Asn Gly Ile Asp Gly Ile 290 295 300 Ala Pro Asn Ala Gln Ile Phe Ser Tyr Lys Met Tyr Ser Asp Ala Gly 305 310 315 320 Ser Gly Phe Ala Gly Asp Glu Thr Met Phe His Ala Ile Glu Asp Ser 325 330 335 Ile Lys His Asn Val Asp Val Val Ser Val Ser Ser Gly Phe Thr Gly 340 345 350 Thr Gly Leu Val Gly Glu Lys Tyr Trp Gln Ala Ile Arg Ala Leu Arg 355 360 365 Lys Ala Gly Ile Pro Met Val Val Ala Thr Gly Asn Tyr Ala Thr Ser 370 375 380 Ala Ser Ser Ser Ser Trp Asp Leu Val Ala Asn Asn His Leu Lys Met 385 390 395 400 Thr Asp Thr Gly Asn Val Thr Arg Thr Ala Ala His Glu Asp Ala Ile 405 410 415 Ala Val Ala Ser Ala Lys Asn Gln Thr Val Glu Phe Asp Lys Val Asn 420 425 430 Ile Gly Gly Glu Ser Phe Lys Tyr Arg Asn Ile Gly Ala Phe Phe Asp 435 440 445 Lys Ser Lys Ile Thr Thr Asn Glu Asp Gly Thr Lys Ala Pro Ser Lys 450 455 460 Leu Lys Phe Val Tyr Ile Gly Lys Gly Gln Asp Gln Asp Leu Ile Gly 465 470 475 480 Leu Asp Leu Arg Gly Lys Ile Ala Val Met Asp Arg Ile Tyr Thr Lys 485 490 495 Asp Leu Lys Asn Ala Phe Lys Lys Ala Met Asp Lys Gly Ala Arg Ala 500 505 510 Ile Met Val Val Asn Thr Val Asn Tyr Tyr Asn Arg Asp Asn Trp Thr 515 520 525 Glu Leu Pro Ala Met Gly Tyr Glu Ala Asp Glu Gly Thr Lys Ser Gln 530 535 540 Val Phe Ser Ile Ser Gly Asp Asp Gly Val Lys Leu Trp Asn Met Ile 545 550 555 560 Asn Pro Asp Lys Lys Thr Glu Val Lys Arg Asn Asn Lys Glu Asp Phe 565 570 575 Lys Asp Lys Leu Glu Gln Tyr Tyr Pro Ile Asp Met Glu Ser Phe Asn 580 585 590 Ser Asn Lys Pro Asn Val Gly Asp Glu Lys Glu Ile Asp Phe Lys Phe 595 600 605 Ala Pro Asp Thr Asp Lys Glu Leu Tyr Lys Glu Asp Ile Ile Val Pro 610 615 620 Ala Gly Ser Thr Ser Trp Gly Pro Arg Ile Asp Leu Leu Leu Lys Pro 625 630 635 640 Asp Val Ser Ala Pro Gly Lys Asn Ile Lys Ser Thr Leu Asn Val Ile 645 650 655 Asn Gly Lys Ser Thr Tyr Gly Tyr Met Ser Gly Thr Ser Met Ala Thr 660 665 670 Pro Ile Val Ala Ala Ser Thr Val Leu Ile Arg Pro Lys Leu Lys Glu 675 680 685 Met Leu Glu Arg Pro Val Leu Lys Asn Leu Lys Gly Asp Asp Lys Ile 690 695 700 Asp Leu Thr Ser Leu Thr Lys Ile Ala Leu Gln Asn Thr Ala Arg Pro 705 710 715 720 Met Met Asp Ala Thr Ser Trp Lys Glu Lys Ser Gln Tyr Phe Ala Ser 725 730 735 Pro Arg Gln Gln Gly Ala Gly Leu Ile Asn Val Ala Asn Ala Leu Arg 740 745 750 Asn Glu Val Val Ala Thr Phe Lys Asn Thr Asp Ser Lys Gly Leu Val 755 760 765 Asn Ser Tyr Gly Ser Ile Ser Leu Lys Glu Ile Lys Gly Asp Lys Lys 770 775 780 Tyr Phe Thr Ile Lys Leu His Asn Thr Ser Asn Arg Pro Leu Thr Phe 785 790 795 800 Lys Val Ser Ala Ser Ala Ile Thr Thr Asp Ser Leu Thr Asp Arg Leu 805 810 815 Lys Leu Asp Glu Thr Tyr Lys Asp Glu Lys Ser Pro Asp Gly Lys Gln 820 825 830 Ile Val Pro Glu Ile His Pro Glu Lys Val Lys Gly Ala Asn Ile Thr 835 840 845 Phe Glu His Asp Thr Phe Thr Ile Gly Ala Asn Ser Ser Phe Asp Leu 850 855 860 Asn Ala Val Ile Asn Val Gly Glu Ala Lys Asn Lys Asn Lys Phe Val 865 870 875 880 Glu Ser Phe Ile His Phe Glu Ser Val Glu Ala Met Glu Ala Leu Asn 885 890 895 Ser Ser Gly Lys Lys Ile Asn Phe Gln Pro Ser Leu Ser Met Pro Leu 900 905 910 Met Gly Phe Ala Gly Asn Trp Asn His Glu Pro Ile Leu Asp Lys Trp 915 920 925 Ala Trp Glu Glu Gly Ser Arg Ser Lys Thr Leu Gly Gly Tyr Asp Asp 930 935 940 Asp Gly Lys Pro Lys Ile Pro Gly Thr Leu Asn Lys Gly Ile Gly Gly 945 950 955 960 Glu His Gly Ile Asp Lys Phe Asn Pro Ala Gly Val Ile Gln Asn Arg 965 970 975 Lys Asp Lys Asn Thr Thr Ser Leu Asp Gln Asn Pro Glu Leu Phe Ala 980 985 990 Phe Asn Asn Glu Gly Ile Asn Ala Pro Ser Ser Ser Gly Ser Lys Ile 995 1000 1005 Ala Asn Ile Tyr Pro Leu Asp Ser Asn Gly Asn Pro Gln Asp Ala Gln 1010 1015 1020 Leu Glu Arg Gly Leu Thr Pro Ser Pro Leu Val Leu Arg Ser Ala Glu 1025 1030 1035 1040 Glu Gly Leu Ile Ser Ile Val Asn Thr Asn Lys Glu Gly Glu Asn Gln 1045 1050 1055 Arg Asp Leu Lys Val Ile Ser Arg Glu His Phe Ile Arg Gly Ile Leu 1060 1065 1070 Asn Ser Lys Ser Asn Asp Ala Lys Gly Ile Lys Ser Ser Lys Leu Lys 1075 1080 1085 Val Trp Gly Asp Leu Lys Trp Asp Gly Leu Ile Tyr Asn Pro Arg Gly 1090 1095 1100 Arg Glu Glu Asn Ala Pro Glu Ser Lys Asp Asn Gln Asp Pro Ala Thr 1105 1110 1115 1120 Lys Ile Arg Gly Gln Phe Glu Pro Ile Ala Glu Gly Gln Tyr Phe Tyr 1125 1130 1135 Lys Phe Lys Tyr Arg Leu Thr Lys Asp Tyr Pro Trp Gln Val Ser Tyr 1140 1145 1150 Ile Pro Val Lys Ile Asp Asn Thr Ala Pro Lys Ile Val Ser Val Asp 1155 1160 1165 Phe Ser Asn Pro Glu Lys Ile Lys Leu Ile Thr Lys Asp Thr Tyr His 1170 1175 1180 Lys Val Lys Asp Gln Tyr Lys Asn Glu Thr Leu Phe Ala Arg Asp Gln 1185 1190 1195 1200 Lys Glu His Pro Glu Lys Phe Asp Glu Ile Ala Asn Glu Val Trp Tyr 1205 1210 1215 Ala Gly Ala Ala Leu Val Asn Glu Asp Gly Glu Val Glu Lys Asn Leu 1220 1225 1230 Glu Val Thr Tyr Ala Gly Glu Gly Gln Gly Arg Asn Arg Lys Leu Asp 1235 1240 1245 Lys Asp Gly Asn Thr Ile Tyr Glu Ile Lys Gly Ala Gly Asp Leu Arg 1250 1255 1260 Gly Lys Ile Ile Glu Val Ile Ala Leu Asp Gly Ser Ser Asn Phe Thr 1265 1270 1275 1280 Lys Ile His Arg Ile Lys Phe Ala Asn Gln Ala Asp Glu Lys Gly Met 1285 1290 1295 Ile Ser Tyr Tyr Leu Val Asp Pro Asp Gln Asp Ser Ser Lys Tyr Gln 1300 1305 1310 Lys Leu Gly Glu Ile Ala Glu Ser Lys Phe Lys Asn Leu Gly Asn Gly 1315 1320 1325 Lys Glu Gly Ser Leu Lys Lys Asp Thr Thr Gly Val Glu His His His 1330 1335 1340 Gln Glu Asn Glu Glu Ser Ile Lys Glu Lys Ser Ser Phe Thr Ile Asp 1345 1350 1355 1360 Arg Asn Ile Ser Thr Ile Arg Asp Phe Glu Asn Lys Asp Leu Lys Lys 1365 1370 1375 Leu Ile Lys Lys Lys Phe Arg Glu Val Asp Asp Phe Thr Ser Glu Thr 1380 1385 1390 Gly Lys Arg Met Glu Glu Tyr Asp Tyr Lys Tyr Asp Asp Lys Gly Asn 1395 1400 1405 Ile Ile Ala Tyr Asp Asp Gly Thr Asp Leu Glu Tyr Glu Thr Glu Lys 1410 1415 1420 Leu Asp Glu Ile Lys Ser Lys Ile Tyr Gly Val Leu Ser Pro Ser Lys 1425 1430 1435 1440 Asp Gly His Phe Glu Ile Leu Gly Lys Ile Ser Asn Val Ser Lys Asn 1445 1450 1455 Ala Lys Val Tyr Tyr Gly Asn Asn Tyr Lys Ser Ile Glu Ile Lys Ala 1460 1465 1470 Thr Lys Tyr Asp Phe His Ser Lys Thr Met Thr Phe Asp Leu Tyr Ala 1475 1480 1485 Asn Ile Asn Asp Ile Val Asp Gly Leu Ala Phe Ala Gly Asp Met Arg 1490 1495 1500 Leu Phe Val Lys Asp Asn Asp Gln Lys Lys Ala Glu Ile Lys Ile Arg 1505 1510 1515 1520 Met Pro Glu Lys Ile Lys Glu Thr Lys Ser Glu Tyr Pro Tyr Val Ser 1525 1530 1535 Ser Tyr Gly Asn Val Ile Glu Leu Gly Glu Gly Asp Leu Ser Lys Asn 1540 1545 1550 Lys Pro Asp Asn Leu Thr Lys Met Glu Ser Gly Lys Ile Tyr Ser Asp 1555 1560 1565 Ser Glu Lys Gln Gln Tyr Leu Leu Lys Asp Asn Ile Ile Leu Arg Lys 1570 1575 1580 Gly Tyr Ala Leu Lys Val Thr Thr Tyr Asn Pro Gly Lys Thr Asp Met 1585 1590 1595 1600 Leu Glu Gly Asn Gly Val Tyr Ser Lys Glu Asp Ile Ala Lys Ile Gln 1605 1610 1615 Lys Ala Asn Pro Asn Leu Arg Ala Leu Ser Glu Thr Thr Ile Tyr Ala 1620 1625 1630 Asp Ser Arg Asn Val Glu Asp Gly Arg Ser Thr Gln Ser Val Leu Met 1635 1640 1645 Ser Ala Leu Asp Gly Phe Asn Ile Ile Arg Tyr Gln Val Phe Thr Phe 1650 1655 1660 Lys Met Asn Asp Lys Gly Glu Ala Ile Asp Lys Asp Gly Asn Leu Val 1665 1670 1675 1680 Thr Asp Ser Ser Lys Leu Val Leu Phe Gly Lys Asp Asp Lys Glu Tyr 1685 1690 1695 Thr Gly Glu Asp Lys Phe Asn Val Glu Ala Ile Lys Glu Asp Gly Ser 1700 1705 1710 Met Leu Phe Ile Asp Thr Lys Pro Val Asn Leu Ser Met Asp Lys Asn 1715 1720 1725 Tyr Phe Asn Pro Ser Lys Ser Asn Lys Ile Tyr Val Arg Asn Pro Glu 1730 1735 1740 Phe Tyr Leu Arg Gly Lys Ile Ser Asp Lys Gly Gly Phe Asn Trp Glu 1745 1750 1755 1760 Leu Arg Val Asn Glu Ser Val Val Asp Asn Tyr Leu Ile Tyr Gly Asp 1765 1770 1775 Leu His Ile Asp Asn Thr Arg Asp Phe Asn Ile Lys Leu Asn Val Lys 1780 1785 1790 Asp Gly Asp Ile Met Asp Trp Gly Met Lys Asp Tyr Lys Ala Asn Gly 1795 1800 1805 Phe Pro Asp Lys Val Thr Asp Met Asp Gly Asn Val Tyr Leu Gln Thr 1810 1815 1820 Gly Tyr Ser Asp Leu Asn Ala Lys Ala Val Gly Val His Tyr Gln Phe 1825 1830 1835 1840 Leu Tyr Asp Asn Val Lys Pro Glu Val Asn Ile Asp Pro Lys Gly Asn 1845 1850 1855 Thr Ser Ile Glu Tyr Ala Asp Gly Lys Ser Val Val Phe Asn Ile Asn 1860 1865 1870 Asp Lys Arg Asn Asn Gly Phe Asp Gly Glu Ile Gln Glu Gln His Ile 1875 1880 1885 Tyr Ile Asn Gly Lys Glu Tyr Thr Ser Phe Asn Asp Ile Lys Gln Ile 1890 1895 1900 Ile Asp Lys Thr Leu Asn Ile Lys Ile Val Val Lys Asp Phe Ala Arg 1905 1910 1915 1920 Asn Thr Thr Val Lys Glu Phe Ile Leu Asn Lys Asp Thr Gly Glu Val 1925 1930 1935 Ser Glu Leu Lys Pro His Arg Val Thr Val Thr Ile Gln Asn Gly Lys 1940 1945 1950 Glu Met Ser Ser Thr Ile Val Ser Glu Glu Asp Phe Ile Leu Pro Val 1955 1960 1965 Tyr Lys Gly Glu Leu Glu Lys Gly Tyr Gln Phe Asp Gly Trp Glu Ile 1970 1975 1980 Ser Gly Phe Glu Gly Lys Lys Asp Ala Gly Tyr Val Ile Asn Leu Ser 1985 1990 1995 2000 Lys Asp Thr Phe Ile Lys Pro Val Phe Lys Lys Ile Glu Glu Lys Lys 2005 2010 2015 Glu Glu Glu Asn Lys Pro Thr Phe Asp Val Ser Lys Lys Lys Asp Asn 2020 2025 2030 Pro Gln Val Asn His Ser Gln Leu Asn Glu Ser His Arg Lys Glu Asp 2035 2040 2045 Leu Gln Arg Glu Glu His Ser Gln Lys Ser Asp Ser Thr Lys Asp Val 2050 2055 2060 Thr Ala Thr Val Leu Asp Lys Asn Asn Ile Ser Ser Lys Ser Thr Thr 2065 2070 2075 2080 Asn Asn Pro Asn Lys Leu Pro Lys Thr Gly Thr Ala Ser Gly Ala Gln 2085 2090 2095 Thr Leu Leu Ala Ala Gly Ile Met Phe Ile Val Gly Ile Phe Leu Gly 2100 2105 2110 Leu Lys Lys Lys Asn Gln Asp 2115 29 597 DNA Streptococcus pneumoniae 29 cttgaattaa ataaaaaacg tcatgcgact aagcatttta ctgataagct tgttgatccc 60 aaagatgtgc gtacggctat cgaaattgca accttagcgc caagcgccca caacagccag 120 ccttggaaat ttgtggtggt acgtgagaaa aatgctgaac tggcaaagtt agcttatggt 180 tccaattttg aacaggtatc atcagcgcct gtaaccattg ccttgtttac agatacggac 240 ttagccaaac gtgctcgtaa gattgcccgt gttggtggtg ctaataactt ttctgaagag 300 caacttcaat attttatgaa aaatctgcca gctgagtttg cccgttacag tgagcaacaa 360 gtcagcgact acctagctct caatgcaggt ttggttgcca tgaacttggt tcttgcattg 420 acagaccaag gaattggttc taacattatt cttggttttg acaaatcaaa agttaatgaa 480 gttttggaaa tcgaagaccg tttccgccca gaactcttga tcacagtggg ttatacagac 540 gaaaaattgg aaccaagcta ccgcttgcca gtagatgaaa tcatcgagaa aagatag 597 30 198 PRT Streptococcus pneumoniae 30 Leu Glu Leu Asn Lys Lys Arg His Ala Thr Lys His Phe Thr Asp Lys 1 5 10 15 Leu Val Asp Pro Lys Asp Val Arg Thr Ala Ile Glu Ile Ala Thr Leu 20 25 30 Ala Pro Ser Ala His Asn Ser Gln Pro Trp Lys Phe Val Val Val Arg 35 40 45 Glu Lys Asn Ala Glu Leu Ala Lys Leu Ala Tyr Gly Ser Asn Phe Glu 50 55 60 Gln Val Ser Ser Ala Pro Val Thr Ile Ala Leu Phe Thr Asp Thr Asp 65 70 75 80 Leu Ala Lys Arg Ala Arg Lys Ile Ala Arg Val Gly Gly Ala Asn Asn 85 90 95 Phe Ser Glu Glu Gln Leu Gln Tyr Phe Met Lys Asn Leu Pro Ala Glu 100 105 110 Phe Ala Arg Tyr Ser Glu Gln Gln Val Ser Asp Tyr Leu Ala Leu Asn 115 120 125 Ala Gly Leu Val Ala Met Asn Leu Val Leu Ala Leu Thr Asp Gln Gly 130 135 140 Ile Gly Ser Asn Ile Ile Leu Gly Phe Asp Lys Ser Lys Val Asn Glu 145 150 155 160 Val Leu Glu Ile Glu Asp Arg Phe Arg Pro Glu Leu Leu Ile Thr Val 165 170 175 Gly Tyr Thr Asp Glu Lys Leu Glu Pro Ser Tyr Arg Leu Pro Val Asp 180 185 190 Glu Ile Ile Glu Lys Arg 195 31 1401 DNA Streptococcus pneumoniae 31 atgacagcaa ttgattttac agcagaagta gaaaaacgca aagaagacct cttggctgac 60 ttgtttagcc ttttggaaat caattcagaa cgtgatgaca gcaaggctga tgcccagcat 120 ccatttgggc ctggtccagt aaaagccttg gagaaattcc ttgaaatcgc agaccgcgat 180 ggctacccaa ctaagaatgt tgataactat gcaggacatt ttgagtttgg tgatggagaa 240 gaagttctcg gaatctttgc ccatatggat gtggtgcctg ctggtagcgg ttgggacaca 300 gacccttaca caccaactat caaagatggt cgcctttatg cgcgcggggc ttcggacgat 360 aagggtccta caacagcttg ttactatggt ttgaaaatca tcaaagaatt gggtcttcca 420 acttctaaga aagttcgctt catcgttgga acagacgaag aatcaggctg ggcagacatg 480 gactactact ttgagcacgt aggacttgcc aaaccagatt tcggtttctc accagatgct 540 gaatttccaa tcatcaatgg tgaaaaagga aatatcacgg aatacctcca ctttgcagga 600 gaaaatacag gtgttgcccg tcttcacagc tttacaggtg gtttacgtga aaatatggta 660 ccagaatcag caacagcagt cgtttcaggt gacttggctg acttgcaagc taaactagat 720 gcctttgttg cagaacacaa acttagagga gaactccaag aagaagctgg caaatacaag 780 gtgacgatca ttggtaaatc agcccacggt gctatgcctg cttcaggtgt caatggcgca 840 acttaccttg ccctcttcct cagccagttt ggctttgctg gtccagccaa agactacctt 900 gacatcgcag gtaaaattct cttgaacgat catgagggtg aaaatcttaa gattgctcat 960 gtggatgaaa agatgggtgc tctttctatg aatgccggcg tcttccactt cgatgaaaca 1020 agtgctgata ataccattgc cctcaacatc cgctatccaa aaggaacaag tccagaacaa 1080 atcaagtcaa tccttgaaaa cttgccagtt gtttctgtta gcctgtctga acacggtcac 1140 acgcctcact atgtgccaat ggaagatcca cttgtgcaaa ccttgttgaa tatctatgaa 1200 aaacaaactg gctttaaagg tcatgaacaa gtcatcggtg gtggaacctt tggtcgcttg 1260 ctagaacgcg gagttgccta cggtgctatg ttcccagact cgattgatac catgcaccaa 1320 gccaatgaat ttatcgcctt ggatgatctt ttccgagcag cagcaattta tgccgaagct 1380 atttacgaat tgatcaaata a 1401 32 466 PRT Streptococcus pneumoniae 32 Met Thr Ala Ile Asp Phe Thr Ala Glu Val Glu Lys Arg Lys Glu Asp 1 5 10 15 Leu Leu Ala Asp Leu Phe Ser Leu Leu Glu Ile Asn Ser Glu Arg Asp 20 25 30 Asp Ser Lys Ala Asp Ala Gln His Pro Phe Gly Pro Gly Pro Val Lys 35 40 45 Ala Leu Glu Lys Phe Leu Glu Ile Ala Asp Arg Asp Gly Tyr Pro Thr 50 55 60 Lys Asn Val Asp Asn Tyr Ala Gly His Phe Glu Phe Gly Asp Gly Glu 65 70 75 80 Glu Val Leu Gly Ile Phe Ala His Met Asp Val Val Pro Ala Gly Ser 85 90 95 Gly Trp Asp Thr Asp Pro Tyr Thr Pro Thr Ile Lys Asp Gly Arg Leu 100 105 110 Tyr Ala Arg Gly Ala Ser Asp Asp Lys Gly Pro Thr Thr Ala Cys Tyr 115 120 125 Tyr Gly Leu Lys Ile Ile Lys Glu Leu Gly Leu Pro Thr Ser Lys Lys 130 135 140 Val Arg Phe Ile Val Gly Thr Asp Glu Glu Ser Gly Trp Ala Asp Met 145 150 155 160 Asp Tyr Tyr Phe Glu His Val Gly Leu Ala Lys Pro Asp Phe Gly Phe 165 170 175 Ser Pro Asp Ala Glu Phe Pro Ile Ile Asn Gly Glu Lys Gly Asn Ile 180 185 190 Thr Glu Tyr Leu His Phe Ala Gly Glu Asn Thr Gly Val Ala Arg Leu 195 200 205 His Ser Phe Thr Gly Gly Leu Arg Glu Asn Met Val Pro Glu Ser Ala 210 215 220 Thr Ala Val Val Ser Gly Asp Leu Ala Asp Leu Gln Ala Lys Leu Asp 225 230 235 240 Ala Phe Val Ala Glu His Lys Leu Arg Gly Glu Leu Gln Glu Glu Ala 245 250 255 Gly Lys Tyr Lys Val Thr Ile Ile Gly Lys Ser Ala His Gly Ala Met 260 265 270 Pro Ala Ser Gly Val Asn Gly Ala Thr Tyr Leu Ala Leu Phe Leu Ser 275 280 285 Gln Phe Gly Phe Ala Gly Pro Ala Lys Asp Tyr Leu Asp Ile Ala Gly 290 295 300 Lys Ile Leu Leu Asn Asp His Glu Gly Glu Asn Leu Lys Ile Ala His 305 310 315 320 Val Asp Glu Lys Met Gly Ala Leu Ser Met Asn Ala Gly Val Phe His 325 330 335 Phe Asp Glu Thr Ser Ala Asp Asn Thr Ile Ala Leu Asn Ile Arg Tyr 340 345 350 Pro Lys Gly Thr Ser Pro Glu Gln Ile Lys Ser Ile Leu Glu Asn Leu 355 360 365 Pro Val Val Ser Val Ser Leu Ser Glu His Gly His Thr Pro His Tyr 370 375 380 Val Pro Met Glu Asp Pro Leu Val Gln Thr Leu Leu Asn Ile Tyr Glu 385 390 395 400 Lys Gln Thr Gly Phe Lys Gly His Glu Gln Val Ile Gly Gly Gly Thr 405 410 415 Phe Gly Arg Leu Leu Glu Arg Gly Val Ala Tyr Gly Ala Met Phe Pro 420 425 430 Asp Ser Ile Asp Thr Met His Gln Ala Asn Glu Phe Ile Ala Leu Asp 435 440 445 Asp Leu Phe Arg Ala Ala Ala Ile Tyr Ala Glu Ala Ile Tyr Glu Leu 450 455 460 Ile Lys 465 33 1617 DNA Streptococcus pneumoniae 33 gtgtatacta ttataaaatc aaatataaaa aaatttagtt tattaacgat atttattgtt 60 gctggtcaat tattgctaat ttatgcagca actattaatg ctctggtgtt gaatgaatta 120 attgcgatga atttagagcg gtttttgaaa ttgtcaatct accaaatgat tgtctggtgt 180 gggataatat tccttgactg ggtagtgaaa aattatcagg ttgaagtgat ccaagagttt 240 aatctagaga ttcgaaatag agttgccaca gacatctcta actctaccta tcaagaattt 300 catagtaaat catcaggaac atatctttcg tggctaaata atgatgttca gactttaaat 360 gatcaggcgt ttaaacaact ttttttagta ataaaaggaa tttctggtac tatatttgca 420 gttgtgactc ttaatcacta tcattggtca ttgactgtag ccaccttgtt ttcattaatg 480 attatgctac ttgtaccaaa aatctttgca tcgaaaatgc gagaagttag tctaaattta 540 actaaccaaa atgaagcttt tttaaaatct agtgagacta tattgaatgg atttgatgtg 600 ttagcgtcct tgaatctttt atatgtattg cctaagaaaa ttaaagaagc aggaatttta 660 ttaaagatgg ttatacaaag aaagacaact gtagaaacgt tagcaggcgc tattagcttc 720 tttctcaata ttttttttca gatatctctc gtttttttaa caggctatct tgcaataaaa 780 ggaatagtga aaattggtac tattgaagca ataggagcac taacaggtgt tatttttaca 840 gcgctaggtg aattaggagg tcaattatcc tctattattg gtacgaagcc tattttttta 900 aaattgtatt caattaatcc aattgagtca aataaaatga atgatatcga accaaatgag 960 gtgaatagag attttccgtt atatgaagca aaaaatattt gctataagta tggagataaa 1020 gaaatattaa aaaacttaaa tttttgtttt caacgtaatg aaaagtattt aattttaggt 1080 gaaagtggaa gcgggaaatc tacattatta aaattattga atggcttttt gagagattat 1140 agtggagaat tgcgattctg cggggatgat ataaaaaaaa cctcctattt aaatatggtt 1200 tcgaatgttc tatatgtaga tcaaaaagct tatttgtttg aaggtacgat tagagataat 1260 attttattgg aagaaaatta tactgatgaa gaaatactac agtctttaga gcaagttggt 1320 ttgagtgtaa aagattttcc taataacatt ttagattatt atgttggtga tgatgggaga 1380 ttactgtcag gagggcagaa acaaaaaatt actttagcta gagggctaat tagaaataag 1440 aaaatagtat taattgacga gggaacttct gctatcgata ggagaacttc gttagcgatt 1500 gaacgtaaga tattagatag agaggatttg actgtcatta ttgttaccca tgctccgcat 1560 ccggaactta aacaatattt tactaagata tatcaatttc caaaggattt tatttaa 1617 34 538 PRT Streptococcus pneumoniae 34 Met Tyr Thr Ile Ile Lys Ser Asn Ile Lys Lys Phe Ser Leu Leu Thr 1 5 10 15 Ile Phe Ile Val Ala Gly Gln Leu Leu Leu Ile Tyr Ala Ala Thr Ile 20 25 30 Asn Ala Leu Val Leu Asn Glu Leu Ile Ala Met Asn Leu Glu Arg Phe 35 40 45 Leu Lys Leu Ser Ile Tyr Gln Met Ile Val Trp Cys Gly Ile Ile Phe 50 55 60 Leu Asp Trp Val Val Lys Asn Tyr Gln Val Glu Val Ile Gln Glu Phe 65 70 75 80 Asn Leu Glu Ile Arg Asn Arg Val Ala Thr Asp Ile Ser Asn Ser Thr 85 90 95 Tyr Gln Glu Phe His Ser Lys Ser Ser Gly Thr Tyr Leu Ser Trp Leu 100 105 110 Asn Asn Asp Val Gln Thr Leu Asn Asp Gln Ala Phe Lys Gln Leu Phe 115 120 125 Leu Val Ile Lys Gly Ile Ser Gly Thr Ile Phe Ala Val Val Thr Leu 130 135 140 Asn His Tyr His Trp Ser Leu Thr Val Ala Thr Leu Phe Ser Leu Met 145 150 155 160 Ile Met Leu Leu Val Pro Lys Ile Phe Ala Ser Lys Met Arg Glu Val 165 170 175 Ser Leu Asn Leu Thr Asn Gln Asn Glu Ala Phe Leu Lys Ser Ser Glu 180 185 190 Thr Ile Leu Asn Gly Phe Asp Val Leu Ala Ser Leu Asn Leu Leu Tyr 195 200 205 Val Leu Pro Lys Lys Ile Lys Glu Ala Gly Ile Leu Leu Lys Met Val 210 215 220 Ile Gln Arg Lys Thr Thr Val Glu Thr Leu Ala Gly Ala Ile Ser Phe 225 230 235 240 Phe Leu Asn Ile Phe Phe Gln Ile Ser Leu Val Phe Leu Thr Gly Tyr 245 250 255 Leu Ala Ile Lys Gly Ile Val Lys Ile Gly Thr Ile Glu Ala Ile Gly 260 265 270 Ala Leu Thr Gly Val Ile Phe Thr Ala Leu Gly Glu Leu Gly Gly Gln 275 280 285 Leu Ser Ser Ile Ile Gly Thr Lys Pro Ile Phe Leu Lys Leu Tyr Ser 290 295 300 Ile Asn Pro Ile Glu Ser Asn Lys Met Asn Asp Ile Glu Pro Asn Glu 305 310 315 320 Val Asn Arg Asp Phe Pro Leu Tyr Glu Ala Lys Asn Ile Cys Tyr Lys 325 330 335 Tyr Gly Asp Lys Glu Ile Leu Lys Asn Leu Asn Phe Cys Phe Gln Arg 340 345 350 Asn Glu Lys Tyr Leu Ile Leu Gly Glu Ser Gly Ser Gly Lys Ser Thr 355 360 365 Leu Leu Lys Leu Leu Asn Gly Phe Leu Arg Asp Tyr Ser Gly Glu Leu 370 375 380 Arg Phe Cys Gly Asp Asp Ile Lys Lys Thr Ser Tyr Leu Asn Met Val 385 390 395 400 Ser Asn Val Leu Tyr Val Asp Gln Lys Ala Tyr Leu Phe Glu Gly Thr 405 410 415 Ile Arg Asp Asn Ile Leu Leu Glu Glu Asn Tyr Thr Asp Glu Glu Ile 420 425 430 Leu Gln Ser Leu Glu Gln Val Gly Leu Ser Val Lys Asp Phe Pro Asn 435 440 445 Asn Ile Leu Asp Tyr Tyr Val Gly Asp Asp Gly Arg Leu Leu Ser Gly 450 455 460 Gly Gln Lys Gln Lys Ile Thr Leu Ala Arg Gly Leu Ile Arg Asn Lys 465 470 475 480 Lys Ile Val Leu Ile Asp Glu Gly Thr Ser Ala Ile Asp Arg Arg Thr 485 490 495 Ser Leu Ala Ile Glu Arg Lys Ile Leu Asp Arg Glu Asp Leu Thr Val 500 505 510 Ile Ile Val Thr His Ala Pro His Pro Glu Leu Lys Gln Tyr Phe Thr 515 520 525 Lys Ile Tyr Gln Phe Pro Lys Asp Phe Ile 530 535 35 705 DNA Streptococcus pneumoniae 35 ataacagtta aacagattat ggacgaaata gccgtttcag atatgactgc aaggcgctat 60 ttacaggaat tagctgataa agatttgctg attcgtgtgc atggtggagc tgaaaaactt 120 cgaaccaact cccttttgac taatgagcga tcaaatattg aaaaacaagc cctccaaacg 180 gcagaaaaac aagaaatagc ccattttgca ggcagtctag tagaagaaag agaaactatt 240 ttcattggac caggaacaac attagagttt tttgcgcgtg agttgcctat tgacaatatc 300 cgcgtcgtaa ccaacagtct acctgttttt ctgattttaa gcgaacgaaa attaacagat 360 ttgattttaa taggtggaaa ttatcgcgat attacaggtg cttttgttgg tacattgacc 420 ctacaaaatc tctctaatct ccaattttct aaagctttcg ttagctgtaa tggtattcaa 480 aacggagctc tagctacttt tagcgaggaa gagggagagg ctcaacgcat cgctttaaat 540 aattctaata aaaaatattt actcgcagat catagcaagt tcaataagtt tgatttttat 600 actttttata atgtatcaaa tcttgatact attgtttcag attctaaact aagtgattca 660 atccttttta agctatctaa acacattaaa gtcatcaagc cttaa 705 36 234 PRT Streptococcus pneumoniae 36 Ile Thr Val Lys Gln Ile Met Asp Glu Ile Ala Val Ser Asp Met Thr 1 5 10 15 Ala Arg Arg Tyr Leu Gln Glu Leu Ala Asp Lys Asp Leu Leu Ile Arg 20 25 30 Val His Gly Gly Ala Glu Lys Leu Arg Thr Asn Ser Leu Leu Thr Asn 35 40 45 Glu Arg Ser Asn Ile Glu Lys Gln Ala Leu Gln Thr Ala Glu Lys Gln 50 55 60 Glu Ile Ala His Phe Ala Gly Ser Leu Val Glu Glu Arg Glu Thr Ile 65 70 75 80 Phe Ile Gly Pro Gly Thr Thr Leu Glu Phe Phe Ala Arg Glu Leu Pro 85 90 95 Ile Asp Asn Ile Arg Val Val Thr Asn Ser Leu Pro Val Phe Leu Ile 100 105 110 Leu Ser Glu Arg Lys Leu Thr Asp Leu Ile Leu Ile Gly Gly Asn Tyr 115 120 125 Arg Asp Ile Thr Gly Ala Phe Val Gly Thr Leu Thr Leu Gln Asn Leu 130 135 140 Ser Asn Leu Gln Phe Ser Lys Ala Phe Val Ser Cys Asn Gly Ile Gln 145 150 155 160 Asn Gly Ala Leu Ala Thr Phe Ser Glu Glu Glu Gly Glu Ala Gln Arg 165 170 175 Ile Ala Leu Asn Asn Ser Asn Lys Lys Tyr Leu Leu Ala Asp His Ser 180 185 190 Lys Phe Asn Lys Phe Asp Phe Tyr Thr Phe Tyr Asn Val Ser Asn Leu 195 200 205 Asp Thr Ile Val Ser Asp Ser Lys Leu Ser Asp Ser Ile Leu Phe Lys 210 215 220 Leu Ser Lys His Ile Lys Val Ile Lys Pro 225 230 37 483 DNA Streptococcus pneumoniae 37 atgactgagt tttcgttaga tcttcttcta gaagccatta aactagctcg ttggacctac 60 tactatcact tgaaacagct agacaaaaca gataaagacc aagagcttaa aactgaaatt 120 caatccatct ttatcgaaca caagggaaat tatgcttatc gccgggttca tttagaacta 180 agaaatcgtg gttatctggt aaatcataaa agagttcaag gcttgatgaa agtactcaat 240 ttacaagcta aaatgcgaaa gaaacgaaaa tattcttctc ataaaggaga cgttggtaag 300 aaggcagaga atctcattca agcccaattt gaaggctcta aaacaatgga aaagtgctac 360 acagatgtga ctgaatttgc cattccagca agtactcaaa agctttactt atcaccagtt 420 ttagatggct ttaacagcga aattattgct tttaatcttt cttgttcgcc taatttagaa 480 taa 483 38 160 PRT Streptococcus pneumoniae 38 Met Thr Glu Phe Ser Leu Asp Leu Leu Leu Glu Ala Ile Lys Leu Ala 1 5 10 15 Arg Trp Thr Tyr Tyr Tyr His Leu Lys Gln Leu Asp Lys Thr Asp Lys 20 25 30 Asp Gln Glu Leu Lys Thr Glu Ile Gln Ser Ile Phe Ile Glu His Lys 35 40 45 Gly Asn Tyr Ala Tyr Arg Arg Val His Leu Glu Leu Arg Asn Arg Gly 50 55 60 Tyr Leu Val Asn His Lys Arg Val Gln Gly Leu Met Lys Val Leu Asn 65 70 75 80 Leu Gln Ala Lys Met Arg Lys Lys Arg Lys Tyr Ser Ser His Lys Gly 85 90 95 Asp Val Gly Lys Lys Ala Glu Asn Leu Ile Gln Ala Gln Phe Glu Gly 100 105 110 Ser Lys Thr Met Glu Lys Cys Tyr Thr Asp Val Thr Glu Phe Ala Ile 115 120 125 Pro Ala Ser Thr Gln Lys Leu Tyr Leu Ser Pro Val Leu Asp Gly Phe 130 135 140 Asn Ser Glu Ile Ile Ala Phe Asn Leu Ser Cys Ser Pro Asn Leu Glu 145 150 155 160 39 1266 DNA Streptococcus pneumoniae 39 ccaggatttg gtaccgttgc aagtggtgtg cctttcctcc taaaggaaaa tggaggaaaa 60 atcaatcaat cagcacattc agatatcaaa gttgctaagg tattggtcaa ggatgaagat 120 gaaaaaaatc gcttgcttgc agcagggaat gactttaact ttgtaaccaa tgtggatgat 180 attttatcag accaggatat tactatcgta gtggaattga tggggcgtat tgagcctgct 240 aaaaccttta tcactcgtgc cttggaagct ggaaaacacg ttgttactgc taacaaggac 300 cttttagctg tccatggcgc agaattgcta gaaatcgctc aagctaacaa ggtagcactt 360 tactacgaag cagcagttgc tggtgggatt ccaattcttc gtactttagc aaattccttg 420 gcttctgata aaattacgcg cgtgcttgga gtagtcaacg gaacttccaa cttcatggtg 480 accaagatgg tggaagaagg ctggtcttac gatgatgctc ttgcggaagc acaacgtcta 540 ggatttgcag aaagcgatcc gacgaatgac gtagatggga ttgatgcagc ctacaagatg 600 gttattttga gccaatttgc ctttggcatg aagattgcct ttgatgatgt agcccacaag 660 ggaatccgca atatcacacc agaagacgta gctgtagctc aagagcttgg ttacgtagtg 720 aaattggttg gttctattga ggaaacttct tcaggtattg ctgcagaagt gactccaacc 780 ttcctaccta aagcgcaccc acttgctagt gtgaatggcg taatgaacgc tgtctttgta 840 gaatctatcg gtattggtga gtctatgtac tacggaccag gtgcgggtca aaaaccaact 900 gcaacaagtg ttgtagctga tattgtccgt atcgttcgtc gtttgaatga tggtactatt 960 ggcaaagact tcaacgaata tagccgtgac ttggtcttgg caaatcctga agatgtcaaa 1020 gcaaactact atttctcaat cttggctcta gactcaaaag gtcaggtctt gaagttggct 1080 gaaatcttca atgctcaaga tatttccttt aagcaaatcc ttcaagatgg caaagagggt 1140 gacaaggcgc gtgtcgttat catcacacac aagattaata aagcccagct tgaaaatgtc 1200 tcagctgaat tgaagaaggt ttcagaattc gacctcttga ataccttcaa ggtgctagga 1260 gaataa 1266 40 421 PRT Streptococcus pneumoniae 40 Pro Gly Phe Gly Thr Val Ala Ser Gly Val Pro Phe Leu Leu Lys Glu 1 5 10 15 Asn Gly Gly Lys Ile Asn Gln Ser Ala His Ser Asp Ile Lys Val Ala 20 25 30 Lys Val Leu Val Lys Asp Glu Asp Glu Lys Asn Arg Leu Leu Ala Ala 35 40 45 Gly Asn Asp Phe Asn Phe Val Thr Asn Val Asp Asp Ile Leu Ser Asp 50 55 60 Gln Asp Ile Thr Ile Val Val Glu Leu Met Gly Arg Ile Glu Pro Ala 65 70 75 80 Lys Thr Phe Ile Thr Arg Ala Leu Glu Ala Gly Lys His Val Val Thr 85 90 95 Ala Asn Lys Asp Leu Leu Ala Val His Gly Ala Glu Leu Leu Glu Ile 100 105 110 Ala Gln Ala Asn Lys Val Ala Leu Tyr Tyr Glu Ala Ala Val Ala Gly 115 120 125 Gly Ile Pro Ile Leu Arg Thr Leu Ala Asn Ser Leu Ala Ser Asp Lys 130 135 140 Ile Thr Arg Val Leu Gly Val Val Asn Gly Thr Ser Asn Phe Met Val 145 150 155 160 Thr Lys Met Val Glu Glu Gly Trp Ser Tyr Asp Asp Ala Leu Ala Glu 165 170 175 Ala Gln Arg Leu Gly Phe Ala Glu Ser Asp Pro Thr Asn Asp Val Asp 180 185 190 Gly Ile Asp Ala Ala Tyr Lys Met Val Ile Leu Ser Gln Phe Ala Phe 195 200 205 Gly Met Lys Ile Ala Phe Asp Asp Val Ala His Lys Gly Ile Arg Asn 210 215 220 Ile Thr Pro Glu Asp Val Ala Val Ala Gln Glu Leu Gly Tyr Val Val 225 230 235 240 Lys Leu Val Gly Ser Ile Glu Glu Thr Ser Ser Gly Ile Ala Ala Glu 245 250 255 Val Thr Pro Thr Phe Leu Pro Lys Ala His Pro Leu Ala Ser Val Asn 260 265 270 Gly Val Met Asn Ala Val Phe Val Glu Ser Ile Gly Ile Gly Glu Ser 275 280 285 Met Tyr Tyr Gly Pro Gly Ala Gly Gln Lys Pro Thr Ala Thr Ser Val 290 295 300 Val Ala Asp Ile Val Arg Ile Val Arg Arg Leu Asn Asp Gly Thr Ile 305 310 315 320 Gly Lys Asp Phe Asn Glu Tyr Ser Arg Asp Leu Val Leu Ala Asn Pro 325 330 335 Glu Asp Val Lys Ala Asn Tyr Tyr Phe Ser Ile Leu Ala Leu Asp Ser 340 345 350 Lys Gly Gln Val Leu Lys Leu Ala Glu Ile Phe Asn Ala Gln Asp Ile 355 360 365 Ser Phe Lys Gln Ile Leu Gln Asp Gly Lys Glu Gly Asp Lys Ala Arg 370 375 380 Val Val Ile Ile Thr His Lys Ile Asn Lys Ala Gln Leu Glu Asn Val 385 390 395 400 Ser Ala Glu Leu Lys Lys Val Ser Glu Phe Asp Leu Leu Asn Thr Phe 405 410 415 Lys Val Leu Gly Glu 420 41 1725 DNA Streptococcus pneumoniae 41 atgaaacacc tattatctta cttcaaaccc tacatcaagg aatcaatttt agcccccttg 60 ttcaagctgt tagaagctgt ttttgagctc ttggttccca tggtgattgc tgggattgtt 120 gaccaatctt tacctcaggg agatcaaggt catctctgga tgcagattgg cctgctcctt 180 atctttgcag taattggcgt tttagtggcc ttgatagctc aattttactc agcaaaggca 240 gcagtaggtt ctgctaagga attgacaaac gatctttatc gtcatattct ttccttgccc 300 aaggacagca gagaccgtct gacaacttct agtttggtca ctcgcttgac ttcggatacc 360 taccagattc agactggtat caatcaattc ctgcgtctct ttttacgagc gcccattatc 420 gtttttggtg ccatttttat ggcttatcga atctcagctg agttgacttt ctggttctta 480 gtcttggttg ccattttgac cattgtcatt gtagggttat ctcgattggt caatcctttc 540 tacagtagtc tcagaaagaa aacggaccaa ctggttcagg aaacgcgcca gcaattgcaa 600 gggatgcggg ttattcgtgc ttttggtcaa gaaaaacgag agttacagat ttttcaaacc 660 cttaaccaag tttatgctag attacaagaa aagacaggtt tctggtctag tttattaaca 720 cctctgacct atctgattgt caatggaact cttctcgtta ttatctggca aggctatatt 780 tcaattcaag gaggagtgct cagtcaaggt gctctcattg ctcttatcaa ttacctctta 840 cagattttgg tggaattggt caagctagcc atgttgatca attccctcaa ccagtcctat 900 atctcagtca agcgaatcga ggaagtcttt gttgaggctc cagaggatat ccattcagag 960 ttagaacaaa agcaagctac cagagataag gttttacaag tccaagaatt gacctttacc 1020 tatcctgatg cggcccagcc ttctctgaga tacatttcct ttgatatgac tcaaggacaa 1080 attctaggta tcatcggggg aactggttct ggtaaatcaa gcttggtgca actcttactt 1140 ggactttatc cagtagacaa ggggaacatt gacctttatc aaaatggacg tagtcctctt 1200 aatttggagc agtggcggtc ttggattgcc tatgtacctc aaaaggtcga actctttaaa 1260 ggaaccattc gttccaactt gactctaggt ttcaatcaag aagtatctga ccaggaactc 1320 tggcaggcct tggagattgc gcaagctaag gattttgtca gtgaaaagga aggactcttg 1380 gatgctctag ttgaggcagg ggggcgaaat ttctcaggtg gacaaaaaca aagattgtct 1440 atcgcccgag cagtcttgcg ccaggctccg tttctcatcc tagatgatgc aacctcggca 1500 ctggatacca ttacagagtc caagctcttg aaagctatta gagaaaattt tccaaacacg 1560 agcttaattt tgatctctca acgaacctca actttacaga tggcggacca gattctcctc 1620 ttggaaaaag gtgagttgct agctgttggc aagcacgatg acttgatgaa atccagccaa 1680 gtctattgtg aaatcaatgc atcccaacat ggaaaggagg actag 1725 42 574 PRT Streptococcus pneumoniae 42 Met Lys His Leu Leu Ser Tyr Phe Lys Pro Tyr Ile Lys Glu Ser Ile 1 5 10 15 Leu Ala Pro Leu Phe Lys Leu Leu Glu Ala Val Phe Glu Leu Leu Val 20 25 30 Pro Met Val Ile Ala Gly Ile Val Asp Gln Ser Leu Pro Gln Gly Asp 35 40 45 Gln Gly His Leu Trp Met Gln Ile Gly Leu Leu Leu Ile Phe Ala Val 50 55 60 Ile Gly Val Leu Val Ala Leu Ile Ala Gln Phe Tyr Ser Ala Lys Ala 65 70 75 80 Ala Val Gly Ser Ala Lys Glu Leu Thr Asn Asp Leu Tyr Arg His Ile 85 90 95 Leu Ser Leu Pro Lys Asp Ser Arg Asp Arg Leu Thr Thr Ser Ser Leu 100 105 110 Val Thr Arg Leu Thr Ser Asp Thr Tyr Gln Ile Gln Thr Gly Ile Asn 115 120 125 Gln Phe Leu Arg Leu Phe Leu Arg Ala Pro Ile Ile Val Phe Gly Ala 130 135 140 Ile Phe Met Ala Tyr Arg Ile Ser Ala Glu Leu Thr Phe Trp Phe Leu 145 150 155 160 Val Leu Val Ala Ile Leu Thr Ile Val Ile Val Gly Leu Ser Arg Leu 165 170 175 Val Asn Pro Phe Tyr Ser Ser Leu Arg Lys Lys Thr Asp Gln Leu Val 180 185 190 Gln Glu Thr Arg Gln Gln Leu Gln Gly Met Arg Val Ile Arg Ala Phe 195 200 205 Gly Gln Glu Lys Arg Glu Leu Gln Ile Phe Gln Thr Leu Asn Gln Val 210 215 220 Tyr Ala Arg Leu Gln Glu Lys Thr Gly Phe Trp Ser Ser Leu Leu Thr 225 230 235 240 Pro Leu Thr Tyr Leu Ile Val Asn Gly Thr Leu Leu Val Ile Ile Trp 245 250 255 Gln Gly Tyr Ile Ser Ile Gln Gly Gly Val Leu Ser Gln Gly Ala Leu 260 265 270 Ile Ala Leu Ile Asn Tyr Leu Leu Gln Ile Leu Val Glu Leu Val Lys 275 280 285 Leu Ala Met Leu Ile Asn Ser Leu Asn Gln Ser Tyr Ile Ser Val Lys 290 295 300 Arg Ile Glu Glu Val Phe Val Glu Ala Pro Glu Asp Ile His Ser Glu 305 310 315 320 Leu Glu Gln Lys Gln Ala Thr Arg Asp Lys Val Leu Gln Val Gln Glu 325 330 335 Leu Thr Phe Thr Tyr Pro Asp Ala Ala Gln Pro Ser Leu Arg Tyr Ile 340 345 350 Ser Phe Asp Met Thr Gln Gly Gln Ile Leu Gly Ile Ile Gly Gly Thr 355 360 365 Gly Ser Gly Lys Ser Ser Leu Val Gln Leu Leu Leu Gly Leu Tyr Pro 370 375 380 Val Asp Lys Gly Asn Ile Asp Leu Tyr Gln Asn Gly Arg Ser Pro Leu 385 390 395 400 Asn Leu Glu Gln Trp Arg Ser Trp Ile Ala Tyr Val Pro Gln Lys Val 405 410 415 Glu Leu Phe Lys Gly Thr Ile Arg Ser Asn Leu Thr Leu Gly Phe Asn 420 425 430 Gln Glu Val Ser Asp Gln Glu Leu Trp Gln Ala Leu Glu Ile Ala Gln 435 440 445 Ala Lys Asp Phe Val Ser Glu Lys Glu Gly Leu Leu Asp Ala Leu Val 450 455 460 Glu Ala Gly Gly Arg Asn Phe Ser Gly Gly Gln Lys Gln Arg Leu Ser 465 470 475 480 Ile Ala Arg Ala Val Leu Arg Gln Ala Pro Phe Leu Ile Leu Asp Asp 485 490 495 Ala Thr Ser Ala Leu Asp Thr Ile Thr Glu Ser Lys Leu Leu Lys Ala 500 505 510 Ile Arg Glu Asn Phe Pro Asn Thr Ser Leu Ile Leu Ile Ser Gln Arg 515 520 525 Thr Ser Thr Leu Gln Met Ala Asp Gln Ile Leu Leu Leu Glu Lys Gly 530 535 540 Glu Leu Leu Ala Val Gly Lys His Asp Asp Leu Met Lys Ser Ser Gln 545 550 555 560 Val Tyr Cys Glu Ile Asn Ala Ser Gln His Gly Lys Glu Asp 565 570 43 1224 DNA Streptococcus pneumoniae 43 atgaaacgtt ctctcgactc aagagtcgat tacagtttgc tcttgccagt attttttcta 60 ctggtcatcg gtgtggtggc tatctatata gccgttagtc atgattatcc caataatatt 120 ctgcccattt tagggcagca ggtcgcctgg attgccttgg ggcttgtgat tggttttgtg 180 gtcatgctct ttaatacaga atttctttgg aaggtgaccc cctttctata tattttaggc 240 ttgggactta tgatcttgcc gattgtattt tataatccaa gcttagttgc atcaacgggt 300 gccaaaaact gggtatcaat aaatggaatt accctattcc aaccgtcaga atttatgaag 360 atatcctata tcctcatgtt ggctcgtgtc attgtccaat ttacaaagaa acataaggaa 420 tggagacgca cggttccgct ggactttttg ttaattttct ggatgattct ctttaccatt 480 ccagtcctag ttcttttagc acttcaaagt gacttgggga cggctttggt ttttgtagcc 540 attttctcag gaatcgtttt attatcaggg gtttcttgga aaattattat cccagtattt 600 gtgactgctg taacaggagt tgctggtttc ttagctatct ttattagcaa ggacggacga 660 gcttttcttc accagattgg aatgccgacc taccaaatta atcggatttt ggcttggctc 720 aatccctttg agtttgccca aacaacgact taccagcagg ctcaagggca gattgccatt 780 gggagtggtg gcttatttgg tcagggattt aatgcttcga atctgcttat cccagttcga 840 gagtcagata tgatttttac ggttattgca gaagattttg gctttattgg ctctgtcctg 900 gttattgccc tctatctcat gttgatttac cgtatgttga agattactct taaatcaaat 960 aaccagttct acacttatat ttccacaggt ttgattatga tgttgctctt ccacatcttt 1020 gagaatatcg gtgctgtgac tggactactt cctttgacgg ggattccctt gcctttcatt 1080 tcgcaagggg gatcagctat tatcagtaat ctgattggtg ttggtttgct tttatcgatg 1140 agttaccaga ctaatctagc tgaagaaaag agcggaaaag tcccattcaa acggaaaaag 1200 gttgtattaa aacaaattaa ataa 1224 44 407 PRT Streptococcus pneumoniae 44 Met Lys Arg Ser Leu Asp Ser Arg Val Asp Tyr Ser Leu Leu Leu Pro 1 5 10 15 Val Phe Phe Leu Leu Val Ile Gly Val Val Ala Ile Tyr Ile Ala Val 20 25 30 Ser His Asp Tyr Pro Asn Asn Ile Leu Pro Ile Leu Gly Gln Gln Val 35 40 45 Ala Trp Ile Ala Leu Gly Leu Val Ile Gly Phe Val Val Met Leu Phe 50 55 60 Asn Thr Glu Phe Leu Trp Lys Val Thr Pro Phe Leu Tyr Ile Leu Gly 65 70 75 80 Leu Gly Leu Met Ile Leu Pro Ile Val Phe Tyr Asn Pro Ser Leu Val 85 90 95 Ala Ser Thr Gly Ala Lys Asn Trp Val Ser Ile Asn Gly Ile Thr Leu 100 105 110 Phe Gln Pro Ser Glu Phe Met Lys Ile Ser Tyr Ile Leu Met Leu Ala 115 120 125 Arg Val Ile Val Gln Phe Thr Lys Lys His Lys Glu Trp Arg Arg Thr 130 135 140 Val Pro Leu Asp Phe Leu Leu Ile Phe Trp Met Ile Leu Phe Thr Ile 145 150 155 160 Pro Val Leu Val Leu Leu Ala Leu Gln Ser Asp Leu Gly Thr Ala Leu 165 170 175 Val Phe Val Ala Ile Phe Ser Gly Ile Val Leu Leu Ser Gly Val Ser 180 185 190 Trp Lys Ile Ile Ile Pro Val Phe Val Thr Ala Val Thr Gly Val Ala 195 200 205 Gly Phe Leu Ala Ile Phe Ile Ser Lys Asp Gly Arg Ala Phe Leu His 210 215 220 Gln Ile Gly Met Pro Thr Tyr Gln Ile Asn Arg Ile Leu Ala Trp Leu 225 230 235 240 Asn Pro Phe Glu Phe Ala Gln Thr Thr Thr Tyr Gln Gln Ala Gln Gly 245 250 255 Gln Ile Ala Ile Gly Ser Gly Gly Leu Phe Gly Gln Gly Phe Asn Ala 260 265 270 Ser Asn Leu Leu Ile Pro Val Arg Glu Ser Asp Met Ile Phe Thr Val 275 280 285 Ile Ala Glu Asp Phe Gly Phe Ile Gly Ser Val Leu Val Ile Ala Leu 290 295 300 Tyr Leu Met Leu Ile Tyr Arg Met Leu Lys Ile Thr Leu Lys Ser Asn 305 310 315 320 Asn Gln Phe Tyr Thr Tyr Ile Ser Thr Gly Leu Ile Met Met Leu Leu 325 330 335 Phe His Ile Phe Glu Asn Ile Gly Ala Val Thr Gly Leu Leu Pro Leu 340 345 350 Thr Gly Ile Pro Leu Pro Phe Ile Ser Gln Gly Gly Ser Ala Ile Ile 355 360 365 Ser Asn Leu Ile Gly Val Gly Leu Leu Leu Ser Met Ser Tyr Gln Thr 370 375 380 Asn Leu Ala Glu Glu Lys Ser Gly Lys Val Pro Phe Lys Arg Lys Lys 385 390 395 400 Val Val Leu Lys Gln Ile Lys 405 45 1104 DNA Streptococcus pneumoniae 45 atggtggcta agaaaaaaat cttatttttt atgtggtctt tttctcttgg aggtggtgca 60 gagaagattc tatcaaccat tgtttcaaat ctggatccag aaaagtatga tattgatatt 120 cttgaaatgg agcactttga caagggatat gaatctgttc caaagcatgt acgcatttta 180 aaatcccttc aagattatcg ccaaaccaga tggttacgag cttttttgtg gagaatgaga 240 atttattttc caagactgac tcgtcgtttg cttgtaaaag atgattatga tgttgaagtt 300 tcttttacca ttatgaatcc accactgttg ttctctaaaa gaagagaagt caagaagata 360 tcttggattc atggaagtat tgaagaactt cttaaggata gctctaaaag agaatcacat 420 agaagccagt tggatgctgc gaatacaatt gtagggattt caaaaaagac cagcaattct 480 atcaaggaag tttatccaga ttatacttct aaattacaga caatctacaa tggatatgat 540 tttcagacta ttctagaaaa atctcaagag aagatcgata tcgagattgc tcctcaaagt 600 atctgtacta tcggacggat tgaggaaaat aagggttctg accgtgtagt ggaagtgata 660 cgattattac accaagaggg aaaaaactat catctctatt ttatcggggc tggtgatatg 720 gaagaggaac tgaaaaaacg agtcaaagag tatgggattg aggactatgt acatttcctt 780 ggttatcaaa aaaatcctta tcagtatcta tctcagacga aagttctttt gtctatgtct 840 aaacaagaag gttttcctgg agtgtatgtg gaggccttga gtctgggact cccttttatc 900 tctacggacg ttggaggggc tgaggaatta tcccaagaag gacgatttgg acaaatcatt 960 gagagcaatc aagaggcagc tcaggcgatt actaattaca tgacttctgc ctcaaacttt 1020 gatgtcgatg aggctagcca attcattcaa caatttacaa ttacaaaaca aatcgaacaa 1080 gtagaaaaac tattagagga gtag 1104 46 367 PRT Streptococcus pneumoniae 46 Met Val Ala Lys Lys Lys Ile Leu Phe Phe Met Trp Ser Phe Ser Leu 1 5 10 15 Gly Gly Gly Ala Glu Lys Ile Leu Ser Thr Ile Val Ser Asn Leu Asp 20 25 30 Pro Glu Lys Tyr Asp Ile Asp Ile Leu Glu Met Glu His Phe Asp Lys 35 40 45 Gly Tyr Glu Ser Val Pro Lys His Val Arg Ile Leu Lys Ser Leu Gln 50 55 60 Asp Tyr Arg Gln Thr Arg Trp Leu Arg Ala Phe Leu Trp Arg Met Arg 65 70 75 80 Ile Tyr Phe Pro Arg Leu Thr Arg Arg Leu Leu Val Lys Asp Asp Tyr 85 90 95 Asp Val Glu Val Ser Phe Thr Ile Met Asn Pro Pro Leu Leu Phe Ser 100 105 110 Lys Arg Arg Glu Val Lys Lys Ile Ser Trp Ile His Gly Ser Ile Glu 115 120 125 Glu Leu Leu Lys Asp Ser Ser Lys Arg Glu Ser His Arg Ser Gln Leu 130 135 140 Asp Ala Ala Asn Thr Ile Val Gly Ile Ser Lys Lys Thr Ser Asn Ser 145 150 155 160 Ile Lys Glu Val Tyr Pro Asp Tyr Thr Ser Lys Leu Gln Thr Ile Tyr 165 170 175 Asn Gly Tyr Asp Phe Gln Thr Ile Leu Glu Lys Ser Gln Glu Lys Ile 180 185 190 Asp Ile Glu Ile Ala Pro Gln Ser Ile Cys Thr Ile Gly Arg Ile Glu 195 200 205 Glu Asn Lys Gly Ser Asp Arg Val Val Glu Val Ile Arg Leu Leu His 210 215 220 Gln Glu Gly Lys Asn Tyr His Leu Tyr Phe Ile Gly Ala Gly Asp Met 225 230 235 240 Glu Glu Glu Leu Lys Lys Arg Val Lys Glu Tyr Gly Ile Glu Asp Tyr 245 250 255 Val His Phe Leu Gly Tyr Gln Lys Asn Pro Tyr Gln Tyr Leu Ser Gln 260 265 270 Thr Lys Val Leu Leu Ser Met Ser Lys Gln Glu Gly Phe Pro Gly Val 275 280 285 Tyr Val Glu Ala Leu Ser Leu Gly Leu Pro Phe Ile Ser Thr Asp Val 290 295 300 Gly Gly Ala Glu Glu Leu Ser Gln Glu Gly Arg Phe Gly Gln Ile Ile 305 310 315 320 Glu Ser Asn Gln Glu Ala Ala Gln Ala Ile Thr Asn Tyr Met Thr Ser 325 330 335 Ala Ser Asn Phe Asp Val Asp Glu Ala Ser Gln Phe Ile Gln Gln Phe 340 345 350 Thr Ile Thr Lys Gln Ile Glu Gln Val Glu Lys Leu Leu Glu Glu 355 360 365 47 987 DNA Streptococcus pneumoniae 47 atggaaactg cattaattag tgtgattgtg ccagtctata atgtggcgca gtacctagaa 60 aaatcgatag cttccattca gaagcagacc tatcaaaatc tggaaattat tcttgttgat 120 gatggtgcaa cagatgaaag tggtcgcttg tgtgattcaa tcgctgaaca agatgacagg 180 gtgtcagtgc ttcataaaaa gaacgaagga ttgtcgcaag cacgaaatga tgggatgaag 240 caggctcacg gggattatct gatttttatt gactcagatg attatatcca tccagaaatg 300 attcagagct tatatgagca attagttcaa gaagatgcgg atgtttcgag ctgtggtgtc 360 atgaatgtct atgctaatga tgaaagccca cagtcagcca atcaggatga ctattttgtc 420 tgtgattctc aaacatttct aaaggaatac ctcataggtg aaaaaatacc tgggacgatt 480 tgcaataagc taatcaagag acagattgca actgccctat cctttcctaa ggggttgatt 540 tacgaagatg cctattacca ttttgattta atcaagttgg ccaagaagta tgtggttaat 600 actaaaccct attattacta tttccataga ggggatagta ttacgaccaa accctatgca 660 gagaaggatt tagcctatat tgatatctac caaaagtttt ataatgaagt tgtgaaaaac 720 tatcctgact tgaaagaggt cgcttttttc agattggcct atgcccactt ctttattctg 780 gataagatgt tgctagatga tcagtataaa cagtttgaag cctattctca gattcatcgt 840 tttttaaaag gccatgcctt tgctatttct aggaatccaa ttttccgtaa ggggagaaga 900 attagtgctt tggccctatt cataaatatt tccttatatc gattcttatt actgaaaaat 960 attgaaaaat ctaaaaaatt acattag 987 48 328 PRT Streptococcus pneumoniae 48 Met Glu Thr Ala Leu Ile Ser Val Ile Val Pro Val Tyr Asn Val Ala 1 5 10 15 Gln Tyr Leu Glu Lys Ser Ile Ala Ser Ile Gln Lys Gln Thr Tyr Gln 20 25 30 Asn Leu Glu Ile Ile Leu Val Asp Asp Gly Ala Thr Asp Glu Ser Gly 35 40 45 Arg Leu Cys Asp Ser Ile Ala Glu Gln Asp Asp Arg Val Ser Val Leu 50 55 60 His Lys Lys Asn Glu Gly Leu Ser Gln Ala Arg Asn Asp Gly Met Lys 65 70 75 80 Gln Ala His Gly Asp Tyr Leu Ile Phe Ile Asp Ser Asp Asp Tyr Ile 85 90 95 His Pro Glu Met Ile Gln Ser Leu Tyr Glu Gln Leu Val Gln Glu Asp 100 105 110 Ala Asp Val Ser Ser Cys Gly Val Met Asn Val Tyr Ala Asn Asp Glu 115 120 125 Ser Pro Gln Ser Ala Asn Gln Asp Asp Tyr Phe Val Cys Asp Ser Gln 130 135 140 Thr Phe Leu Lys Glu Tyr Leu Ile Gly Glu Lys Ile Pro Gly Thr Ile 145 150 155 160 Cys Asn Lys Leu Ile Lys Arg Gln Ile Ala Thr Ala Leu Ser Phe Pro 165 170 175 Lys Gly Leu Ile Tyr Glu Asp Ala Tyr Tyr His Phe Asp Leu Ile Lys 180 185 190 Leu Ala Lys Lys Tyr Val Val Asn Thr Lys Pro Tyr Tyr Tyr Tyr Phe 195 200 205 His Arg Gly Asp Ser Ile Thr Thr Lys Pro Tyr Ala Glu Lys Asp Leu 210 215 220 Ala Tyr Ile Asp Ile Tyr Gln Lys Phe Tyr Asn Glu Val Val Lys Asn 225 230 235 240 Tyr Pro Asp Leu Lys Glu Val Ala Phe Phe Arg Leu Ala Tyr Ala His 245 250 255 Phe Phe Ile Leu Asp Lys Met Leu Leu Asp Asp Gln Tyr Lys Gln Phe 260 265 270 Glu Ala Tyr Ser Gln Ile His Arg Phe Leu Lys Gly His Ala Phe Ala 275 280 285 Ile Ser Arg Asn Pro Ile Phe Arg Lys Gly Arg Arg Ile Ser Ala Leu 290 295 300 Ala Leu Phe Ile Asn Ile Ser Leu Tyr Arg Phe Leu Leu Leu Lys Asn 305 310 315 320 Ile Glu Lys Ser Lys Lys Leu His 325 49 735 DNA Streptococcus pneumoniae 49 atgagaatca aagagaaaac caataatatt aatggaggaa taaaaaatgt aagtaagcat 60 tatggtcatt caatcattct caaagatata aattttgcac ttaacaaggg tgaaattgtt 120 ggtctagcag ggagaaatgg agttggtaag agtacgttga tgaaaattct tgttcagaat 180 aatcaaccga cttcaggtaa tattataagc agtgataatg ttgggtattt aatcgaagaa 240 ccaaaattat ttttatctaa aacaggttta gagaatttaa aatatttgtc aaatttatat 300 ggtgttgact acaatcaaga aagatttaga tgtttgatcc aagagttaga tttgactcag 360 tctattaata aaaaagtaaa gacctattct ttgggtacaa aacaaaaatt agctttgctt 420 ctaactctcg ttacggaacc tgatatattg attttagatg aaccgactaa tggtttagat 480 attgaatcat cacaaatagt tttagcggtt ctaaaaaaat tagctttaca tgaaaatgtg 540 ggaattttaa tatcgagtca taaattagaa gacattgaag aaatttgtga gagagttctt 600 ttcttggaga acgggctttt gacatttcaa aaagtaggaa aagatagtca taatttcttg 660 tttgagatag ctttttcatc agctacagat agagacattt tcattaccaa acaagaattt 720 tgggatattg tttag 735 50 244 PRT Streptococcus pneumoniae 50 Met Arg Ile Lys Glu Lys Thr Asn Asn Ile Asn Gly Gly Ile Lys Asn 1 5 10 15 Val Ser Lys His Tyr Gly His Ser Ile Ile Leu Lys Asp Ile Asn Phe 20 25 30 Ala Leu Asn Lys Gly Glu Ile Val Gly Leu Ala Gly Arg Asn Gly Val 35 40 45 Gly Lys Ser Thr Leu Met Lys Ile Leu Val Gln Asn Asn Gln Pro Thr 50 55 60 Ser Gly Asn Ile Ile Ser Ser Asp Asn Val Gly Tyr Leu Ile Glu Glu 65 70 75 80 Pro Lys Leu Phe Leu Ser Lys Thr Gly Leu Glu Asn Leu Lys Tyr Leu 85 90 95 Ser Asn Leu Tyr Gly Val Asp Tyr Asn Gln Glu Arg Phe Arg Cys Leu 100 105 110 Ile Gln Glu Leu Asp Leu Thr Gln Ser Ile Asn Lys Lys Val Lys Thr 115 120 125 Tyr Ser Leu Gly Thr Lys Gln Lys Leu Ala Leu Leu Leu Thr Leu Val 130 135 140 Thr Glu Pro Asp Ile Leu Ile Leu Asp Glu Pro Thr Asn Gly Leu Asp 145 150 155 160 Ile Glu Ser Ser Gln Ile Val Leu Ala Val Leu Lys Lys Leu Ala Leu 165 170 175 His Glu Asn Val Gly Ile Leu Ile Ser Ser His Lys Leu Glu Asp Ile 180 185 190 Glu Glu Ile Cys Glu Arg Val Leu Phe Leu Glu Asn Gly Leu Leu Thr 195 200 205 Phe Gln Lys Val Gly Lys Asp Ser His Asn Phe Leu Phe Glu Ile Ala 210 215 220 Phe Ser Ser Ala Thr Asp Arg Asp Ile Phe Ile Thr Lys Gln Glu Phe 225 230 235 240 Trp Asp Ile Val 51 1704 DNA Streptococcus pneumoniae 51 atgactgaat tagataaacg tcaccgcagt agcatttatg acagcatggt taaatcacct 60 aaccgtgcta tgcttcgtgc gactggtatg acagataagg actttgaaac atcgattgtg 120 ggagtgattt cgacttgggc ggaaaataca ccatgtaaca ttcacttgca tgatttcggg 180 aaactggcta aagaaggtgt caaatctgca ggcgcttggc ctgtacagtt tggaaccatt 240 accgtagcgg acgggatcgc tatgggaacg cctggtatgc gtttctctct aacatctcgt 300 gacatcatcg cggactccat cgaggcggct atgagtggtc acaacgtgga tgccttcgtc 360 gctatcggtg gctgtgacaa gaacatgcct ggatctatga ttgctattgc taatatggat 420 atcccagcta ttttcgccta tggtggaact attgcaccgg gaaatcttga tggtaaagat 480 atcgacttgg tttctgtctt tgaaggtatc ggaaaatgga accacggtga catgacagct 540 gaggacgtga aacgtcttga atgtaatgcc tgccctggcc ctggtggttg tggtggtatg 600 tatactgcta ataccatggc aactgctatc gaagttctag ggatgagttt gccagggtca 660 tcctctcacc cagctgaatc agctgataag aaagaagata tcgaagcagc aggacgtgct 720 gttgttaaga tgttggaact tggtctcaaa ccatcagata tcttgactcg tgaagccttt 780 gaagatgcta tcactgtaac gatggctctc ggtggttcta caaacgccac tcttcacttg 840 ctcgccattg cccatgccgc aaatgttgac ttgtcacttg aggacttcaa tacgattcaa 900 gaacgtgtgc ctcacttggc cgacttgaaa ccatctggtc agtatgtctt ccaagacctc 960 tacgaagtcg gtggtgtccc tgcggttatg aagtatttgt tggcaaatgg tttccttcac 1020 ggagatcgca tcacatgtac tggtaagact gtagctgaaa acttggctga ctttgcagac 1080 ttgactccag gccaaaaagt tatcatgcca cttgaaaatc caaaacgtgc ggatggtccg 1140 cttatcatct tgaacgggaa ccttgctcct gacggtgcag ttgccaaggt atcaggtgtt 1200 aaagtgcgtc gtcacgttgg gccagctaag gtctttgact cagaagaaga tgcgattcag 1260 gccgttctga cagatgaaat cgttgatggc gatgtagtcg ttgttcgttt tgttggacct 1320 aaaggtggtc ctggtatgcc tgagatgcta tcactttctt caatgattgt tggtaaaggt 1380 cagggagata aggtggccct cttgacggac ggacgtttct ctggtggtac ttatggtctg 1440 gttgttggac atatcgctcc tgaagctcag gatggtggac caattgccta tctccgtacc 1500 ggcgatatcg ttacggttga ccaagatacc aaagaaattt ctatggccgt atccgaagaa 1560 gaacttgaaa aacgcaaggc agaaacaacc ttgccaccac tttacagccg tggtgtcctc 1620 ggtaaatatg cccacatcgt atcatctgct tcacgcggag ccgtgacaga cttctggaat 1680 atggacaagt caggtaaaaa ataa 1704 52 567 PRT Streptococcus pneumoniae 52 Met Thr Glu Leu Asp Lys Arg His Arg Ser Ser Ile Tyr Asp Ser Met 1 5 10 15 Val Lys Ser Pro Asn Arg Ala Met Leu Arg Ala Thr Gly Met Thr Asp 20 25 30 Lys Asp Phe Glu Thr Ser Ile Val Gly Val Ile Ser Thr Trp Ala Glu 35 40 45 Asn Thr Pro Cys Asn Ile His Leu His Asp Phe Gly Lys Leu Ala Lys 50 55 60 Glu Gly Val Lys Ser Ala Gly Ala Trp Pro Val Gln Phe Gly Thr Ile 65 70 75 80 Thr Val Ala Asp Gly Ile Ala Met Gly Thr Pro Gly Met Arg Phe Ser 85 90 95 Leu Thr Ser Arg Asp Ile Ile Ala Asp Ser Ile Glu Ala Ala Met Ser 100 105 110 Gly His Asn Val Asp Ala Phe Val Ala Ile Gly Gly Cys Asp Lys Asn 115 120 125 Met Pro Gly Ser Met Ile Ala Ile Ala Asn Met Asp Ile Pro Ala Ile 130 135 140 Phe Ala Tyr Gly Gly Thr Ile Ala Pro Gly Asn Leu Asp Gly Lys Asp 145 150 155 160 Ile Asp Leu Val Ser Val Phe Glu Gly Ile Gly Lys Trp Asn His Gly 165 170 175 Asp Met Thr Ala Glu Asp Val Lys Arg Leu Glu Cys Asn Ala Cys Pro 180 185 190 Gly Pro Gly Gly Cys Gly Gly Met Tyr Thr Ala Asn Thr Met Ala Thr 195 200 205 Ala Ile Glu Val Leu Gly Met Ser Leu Pro Gly Ser Ser Ser His Pro 210 215 220 Ala Glu Ser Ala Asp Lys Lys Glu Asp Ile Glu Ala Ala Gly Arg Ala 225 230 235 240 Val Val Lys Met Leu Glu Leu Gly Leu Lys Pro Ser Asp Ile Leu Thr 245 250 255 Arg Glu Ala Phe Glu Asp Ala Ile Thr Val Thr Met Ala Leu Gly Gly 260 265 270 Ser Thr Asn Ala Thr Leu His Leu Leu Ala Ile Ala His Ala Ala Asn 275 280 285 Val Asp Leu Ser Leu Glu Asp Phe Asn Thr Ile Gln Glu Arg Val Pro 290 295 300 His Leu Ala Asp Leu Lys Pro Ser Gly Gln Tyr Val Phe Gln Asp Leu 305 310 315 320 Tyr Glu Val Gly Gly Val Pro Ala Val Met Lys Tyr Leu Leu Ala Asn 325 330 335 Gly Phe Leu His Gly Asp Arg Ile Thr Cys Thr Gly Lys Thr Val Ala 340 345 350 Glu Asn Leu Ala Asp Phe Ala Asp Leu Thr Pro Gly Gln Lys Val Ile 355 360 365 Met Pro Leu Glu Asn Pro Lys Arg Ala Asp Gly Pro Leu Ile Ile Leu 370 375 380 Asn Gly Asn Leu Ala Pro Asp Gly Ala Val Ala Lys Val Ser Gly Val 385 390 395 400 Lys Val Arg Arg His Val Gly Pro Ala Lys Val Phe Asp Ser Glu Glu 405 410 415 Asp Ala Ile Gln Ala Val Leu Thr Asp Glu Ile Val Asp Gly Asp Val 420 425 430 Val Val Val Arg Phe Val Gly Pro Lys Gly Gly Pro Gly Met Pro Glu 435 440 445 Met Leu Ser Leu Ser Ser Met Ile Val Gly Lys Gly Gln Gly Asp Lys 450 455 460 Val Ala Leu Leu Thr Asp Gly Arg Phe Ser Gly Gly Thr Tyr Gly Leu 465 470 475 480 Val Val Gly His Ile Ala Pro Glu Ala Gln Asp Gly Gly Pro Ile Ala 485 490 495 Tyr Leu Arg Thr Gly Asp Ile Val Thr Val Asp Gln Asp Thr Lys Glu 500 505 510 Ile Ser Met Ala Val Ser Glu Glu Glu Leu Glu Lys Arg Lys Ala Glu 515 520 525 Thr Thr Leu Pro Pro Leu Tyr Ser Arg Gly Val Leu Gly Lys Tyr Ala 530 535 540 His Ile Val Ser Ser Ala Ser Arg Gly Ala Val Thr Asp Phe Trp Asn 545 550 555 560 Met Asp Lys Ser Gly Lys Lys 565 53 274 DNA Streptococcus pneumoniae 53 atgttataat aaaaataaag aatttaagga gaaatacaat atgtcaattt ttattggagg 60 agcatggcca tatgcaaacg gttcgttaca tattggtcac gcggcagcgc ttttaccggg 120 ggatattctt gcaagatact atcgtcagaa gggagaggaa gttttatatg tttctggaag 180 tgattgtaat ggaaccccta tttctatcag agctaaaaaa gaaaataagt ctgtgaaaga 240 aattgctgat ttttatcata aggaatttaa tcca 274 54 91 PRT Streptococcus pneumoniae 54 Cys Tyr Asn Lys Asn Lys Glu Phe Lys Glu Lys Tyr Asn Met Ser Ile 1 5 10 15 Phe Ile Gly Gly Ala Trp Pro Tyr Ala Asn Gly Ser Leu His Ile Gly 20 25 30 His Ala Ala Ala Leu Leu Pro Gly Asp Ile Leu Ala Arg Tyr Tyr Arg 35 40 45 Gln Lys Gly Glu Glu Val Leu Tyr Val Ser Gly Ser Asp Cys Asn Gly 50 55 60 Thr Pro Ile Ser Ile Arg Ala Lys Lys Glu Asn Lys Ser Val Lys Glu 65 70 75 80 Ile Ala Asp Phe Tyr His Lys Glu Phe Asn Pro 85 90 55 1065 DNA Streptococcus pneumoniae 55 atgacaacat tattttcaaa aattaaagaa gtaacagaac ttgctgcagt ctcaggtcat 60 gaagcgcctg tccgtgctta tcttcgtgaa aagttgacac cgcatgtgga tgaagtggtg 120 acagatggct tgggtggtat ttttggtatc aaacattcag aagctgtgga tgcaccgcgc 180 gtcttggtcg cttctcatat ggacgaagtt ggttttatgg tcagcgaaat caagccagat 240 ggtaccttcc gtgtcgtaga aatcggtggc tggaacccca tggtggttag cagccaacgt 300 ttcaaactct tgactcgtga tggtcatgaa attcctgtga tttcaggttc tgttcctccg 360 catttgactc gtggaaaggg gggaccaacc atgccagcca ttgccgatat cgtttttgat 420 ggtggttttg cggacaaggc tgaggcagaa agttttggca tccgtcctgg tgataccatt 480 gtaccagata gttctgcaat tttgacagcc aatgaaaaaa atatcatctc aaaagcttgg 540 gataaccgct acggtgtcct catggtaagc gagctagctg aagctttatc gggtcaaaaa 600 ctcggcaatg aactctatct gggttctaac gtccaagaag aagttggtct gcgtggcgct 660 catacctcta caaccaagtt tgacccagaa gtcttcctcg cagttgattg ctcaccagca 720 ggtgatgtct acggtggtca aggcaagatt ggagatggaa ccttgattcg tttctatgat 780 ccaggtcact tgcttctccc agggatgaag gatttccttt tgacaacggc tgaagaagct 840 ggtatcaagt accaatacta ctgtggtaaa ggcggaacag atgcaggtgc agctcatctg 900 aaaaatggtg gtgtcccatc aacaactatc ggtgtctgcg ctcgttatat ccattctcac 960 caaaccctct atgcaatgga tgacttccta gaagcgcaag ctttcttaca agccttggtg 1020 aagaaattgg atcgttcaac ggttgatttg attaaacatt attaa 1065 56 354 PRT Streptococcus pneumoniae 56 Met Thr Thr Leu Phe Ser Lys Ile Lys Glu Val Thr Glu Leu Ala Ala 1 5 10 15 Val Ser Gly His Glu Ala Pro Val Arg Ala Tyr Leu Arg Glu Lys Leu 20 25 30 Thr Pro His Val Asp Glu Val Val Thr Asp Gly Leu Gly Gly Ile Phe 35 40 45 Gly Ile Lys His Ser Glu Ala Val Asp Ala Pro Arg Val Leu Val Ala 50 55 60 Ser His Met Asp Glu Val Gly Phe Met Val Ser Glu Ile Lys Pro Asp 65 70 75 80 Gly Thr Phe Arg Val Val Glu Ile Gly Gly Trp Asn Pro Met Val Val 85 90 95 Ser Ser Gln Arg Phe Lys Leu Leu Thr Arg Asp Gly His Glu Ile Pro 100 105 110 Val Ile Ser Gly Ser Val Pro Pro His Leu Thr Arg Gly Lys Gly Gly 115 120 125 Pro Thr Met Pro Ala Ile Ala Asp Ile Val Phe Asp Gly Gly Phe Ala 130 135 140 Asp Lys Ala Glu Ala Glu Ser Phe Gly Ile Arg Pro Gly Asp Thr Ile 145 150 155 160 Val Pro Asp Ser Ser Ala Ile Leu Thr Ala Asn Glu Lys Asn Ile Ile 165 170 175 Ser Lys Ala Trp Asp Asn Arg Tyr Gly Val Leu Met Val Ser Glu Leu 180 185 190 Ala Glu Ala Leu Ser Gly Gln Lys Leu Gly Asn Glu Leu Tyr Leu Gly 195 200 205 Ser Asn Val Gln Glu Glu Val Gly Leu Arg Gly Ala His Thr Ser Thr 210 215 220 Thr Lys Phe Asp Pro Glu Val Phe Leu Ala Val Asp Cys Ser Pro Ala 225 230 235 240 Gly Asp Val Tyr Gly Gly Gln Gly Lys Ile Gly Asp Gly Thr Leu Ile 245 250 255 Arg Phe Tyr Asp Pro Gly His Leu Leu Leu Pro Gly Met Lys Asp Phe 260 265 270 Leu Leu Thr Thr Ala Glu Glu Ala Gly Ile Lys Tyr Gln Tyr Tyr Cys 275 280 285 Gly Lys Gly Gly Thr Asp Ala Gly Ala Ala His Leu Lys Asn Gly Gly 290 295 300 Val Pro Ser Thr Thr Ile Gly Val Cys Ala Arg Tyr Ile His Ser His 305 310 315 320 Gln Thr Leu Tyr Ala Met Asp Asp Phe Leu Glu Ala Gln Ala Phe Leu 325 330 335 Gln Ala Leu Val Lys Lys Leu Asp Arg Ser Thr Val Asp Leu Ile Lys 340 345 350 His Tyr 57 1182 DNA Streptococcus pneumoniae 57 atggaatttt ctatgaaatc agtcaaagga ctactcttta tcatagctag ttttatcttg 60 actcttttga cttggatgaa cacttctccc caattcatga ttccaggact agctttaaca 120 agcctatctc tgacttttat cctagccact cgtctcccac tactagaaag ctggtttcac 180 agtttggaga aggtctacac cgtccacaaa ttcacagcct ttctctcaat catcctacta 240 atctttcata actttagtat gggcggtttg tggggctctc gcttagctgc tcagtttggc 300 aatcttgcca tctatatctt tgccagcatc atccttgtcg cctatttagg caaatacatc 360 caatacgaag cttggcgatg gattcaccgc ctggtttacc tagcctatat tttaggactc 420 tttcacatct acatgataat gggcaatcgt ctccttacat ttaatcttct aagttttctt 480 gttggtagct atgccctttt aggcttacta gctggttttt atatcatttt tctatatcaa 540 aagatttcct tcccctatct agggaaaatt acccatctca aacgcttaaa tcacgatact 600 agagaaattc aaatccatct tagcagacct ttcaactatc aatcaggaca atttgccttt 660 ctaaagattt tccaagaagg ctttgaaagt gctccgcatc ccttttctat ctcaggaggt 720 catggtcaaa ctctttactt tactgttaaa acttcaggcg accataccaa gaatatctat 780 gataatcttc aagccggcag caaagtaacc ctagacagag cttacggaca catgatcata 840 gaagaaggac gagaaaatca ggtttggatt gctggaggta ttgggatcac ccccttcatc 900 tcttacatcc gtgaacatcc tattttagat aaacaggttc acttctacta tagcttccgt 960 ggagatgaaa atgcagtcta cctagattta ctccgtaact atgctcagaa aaatcctaat 1020 tttgaactcc atctaatcga cagtacgaaa gacggctatc ttaattttga acaaaaagaa 1080 gtgcccgaac atgcaaccgt ctatatgtgt ggtcctattt ctatgatgaa ggcacttgcc 1140 aaacagatta agaaacaaaa tccaaaaaca gagcatattt ac 1182 58 394 PRT Streptococcus pneumoniae 58 Met Glu Phe Ser Met Lys Ser Val Lys Gly Leu Leu Phe Ile Ile Ala 1 5 10 15 Ser Phe Ile Leu Thr Leu Leu Thr Trp Met Asn Thr Ser Pro Gln Phe 20 25 30 Met Ile Pro Gly Leu Ala Leu Thr Ser Leu Ser Leu Thr Phe Ile Leu 35 40 45 Ala Thr Arg Leu Pro Leu Leu Glu Ser Trp Phe His Ser Leu Glu Lys 50 55 60 Val Tyr Thr Val His Lys Phe Thr Ala Phe Leu Ser Ile Ile Leu Leu 65 70 75 80 Ile Phe His Asn Phe Ser Met Gly Gly Leu Trp Gly Ser Arg Leu Ala 85 90 95 Ala Gln Phe Gly Asn Leu Ala Ile Tyr Ile Phe Ala Ser Ile Ile Leu 100 105 110 Val Ala Tyr Leu Gly Lys Tyr Ile Gln Tyr Glu Ala Trp Arg Trp Ile 115 120 125 His Arg Leu Val Tyr Leu Ala Tyr Ile Leu Gly Leu Phe His Ile Tyr 130 135 140 Met Ile Met Gly Asn Arg Leu Leu Thr Phe Asn Leu Leu Ser Phe Leu 145 150 155 160 Val Gly Ser Tyr Ala Leu Leu Gly Leu Leu Ala Gly Phe Tyr Ile Ile 165 170 175 Phe Leu Tyr Gln Lys Ile Ser Phe Pro Tyr Leu Gly Lys Ile Thr His 180 185 190 Leu Lys Arg Leu Asn His Asp Thr Arg Glu Ile Gln Ile His Leu Ser 195 200 205 Arg Pro Phe Asn Tyr Gln Ser Gly Gln Phe Ala Phe Leu Lys Ile Phe 210 215 220 Gln Glu Gly Phe Glu Ser Ala Pro His Pro Phe Ser Ile Ser Gly Gly 225 230 235 240 His Gly Gln Thr Leu Tyr Phe Thr Val Lys Thr Ser Gly Asp His Thr 245 250 255 Lys Asn Ile Tyr Asp Asn Leu Gln Ala Gly Ser Lys Val Thr Leu Asp 260 265 270 Arg Ala Tyr Gly His Met Ile Ile Glu Glu Gly Arg Glu Asn Gln Val 275 280 285 Trp Ile Ala Gly Gly Ile Gly Ile Thr Pro Phe Ile Ser Tyr Ile Arg 290 295 300 Glu His Pro Ile Leu Asp Lys Gln Val His Phe Tyr Tyr Ser Phe Arg 305 310 315 320 Gly Asp Glu Asn Ala Val Tyr Leu Asp Leu Leu Arg Asn Tyr Ala Gln 325 330 335 Lys Asn Pro Asn Phe Glu Leu His Leu Ile Asp Ser Thr Lys Asp Gly 340 345 350 Tyr Leu Asn Phe Glu Gln Lys Glu Val Pro Glu His Ala Thr Val Tyr 355 360 365 Met Cys Gly Pro Ile Ser Met Met Lys Ala Leu Ala Lys Gln Ile Lys 370 375 380 Lys Gln Asn Pro Lys Thr Glu His Ile Tyr 385 390 59 900 DNA Streptococcus pneumoniae 59 atgactttta aatcaggctt tgtagccatt ttaggacgtc ccaatgttgg gaagtcaacc 60 tttttaaatc acgttatggg gcaaaagatt gccatcatga gtgacaaggc gcagacaacg 120 cgcaataaaa tcatgggaat ttacacgact gataaggagc aaattgtctt tatcgacaca 180 ccagggattc acaagcctaa aacagctctc ggagatttca tggttgagtc tgcctacagt 240 acccttcgcg aagtggacac tgttcttttc atggtgcctg ctgatgaagc gcgtggtaag 300 ggggacgata tgattatcga gcgtctcaag gctgccaagg ttcctgtgat tttggtggtg 360 aataaaatcg ataaggtcca tccagaccag ctcttgtctc agattgatga cttccgtaat 420 caaatggact ttaaggaaat tgttccaatc tcagcccttc agggaaataa cgtgtctcgt 480 ctagtggata ttttgagtga aaatctggat gaaggtttcc aatatttccc gtctgatcaa 540 atcacagacc atccagaacg tttcttggtt tcagaaatgg ttcgcgagaa agtcttgcac 600 ctaactcgtg aagagattcc gcattctgta gcagtagttg ttgactctat gaaacgagac 660 gaagagacag acaaggttca catccgtgca accatcatgg tcgagcgcga tagccaaaaa 720 gggattatca tcggtaaagg tggcgctatg cttaagaaaa tcggtagcat ggcccgtcgt 780 gatatcgaac tcatgctagg agacaaggtc ttcctagaaa cctgggtcaa ggtcaagaaa 840 aactggcgcg ataaaaagct agatttggct gactttggct ataatgaaag agaatactaa 900 60 299 PRT Streptococcus pneumoniae 60 Met Thr Phe Lys Ser Gly Phe Val Ala Ile Leu Gly Arg Pro Asn Val 1 5 10 15 Gly Lys Ser Thr Phe Leu Asn His Val Met Gly Gln Lys Ile Ala Ile 20 25 30 Met Ser Asp Lys Ala Gln Thr Thr Arg Asn Lys Ile Met Gly Ile Tyr 35 40 45 Thr Thr Asp Lys Glu Gln Ile Val Phe Ile Asp Thr Pro Gly Ile His 50 55 60 Lys Pro Lys Thr Ala Leu Gly Asp Phe Met Val Glu Ser Ala Tyr Ser 65 70 75 80 Thr Leu Arg Glu Val Asp Thr Val Leu Phe Met Val Pro Ala Asp Glu 85 90 95 Ala Arg Gly Lys Gly Asp Asp Met Ile Ile Glu Arg Leu Lys Ala Ala 100 105 110 Lys Val Pro Val Ile Leu Val Val Asn Lys Ile Asp Lys Val His Pro 115 120 125 Asp Gln Leu Leu Ser Gln Ile Asp Asp Phe Arg Asn Gln Met Asp Phe 130 135 140 Lys Glu Ile Val Pro Ile Ser Ala Leu Gln Gly Asn Asn Val Ser Arg 145 150 155 160 Leu Val Asp Ile Leu Ser Glu Asn Leu Asp Glu Gly Phe Gln Tyr Phe 165 170 175 Pro Ser Asp Gln Ile Thr Asp His Pro Glu Arg Phe Leu Val Ser Glu 180 185 190 Met Val Arg Glu Lys Val Leu His Leu Thr Arg Glu Glu Ile Pro His 195 200 205 Ser Val Ala Val Val Val Asp Ser Met Lys Arg Asp Glu Glu Thr Asp 210 215 220 Lys Val His Ile Arg Ala Thr Ile Met Val Glu Arg Asp Ser Gln Lys 225 230 235 240 Gly Ile Ile Ile Gly Lys Gly Gly Ala Met Leu Lys Lys Ile Gly Ser 245 250 255 Met Ala Arg Arg Asp Ile Glu Leu Met Leu Gly Asp Lys Val Phe Leu 260 265 270 Glu Thr Trp Val Lys Val Lys Lys Asn Trp Arg Asp Lys Lys Leu Asp 275 280 285 Leu Ala Asp Phe Gly Tyr Asn Glu Arg Glu Tyr 290 295 61 855 DNA Streptococcus pneumoniae 61 ctgcttcttg tttttacaga aggaggactt atgcctgaat tacctgaggt tgaaaccgtt 60 tgtcgtggct tagaaaaatt gattatagga aagaagattt cgagtataga aattcgctac 120 cccaagatga ttaagacgga tttggaagag tttcaaaggg aattgcctag tcagattatc 180 gagtcaatgg gacgtcgtgg aaaatatttg cttttttatc tgacagacaa ggtcttgatt 240 tcccatttgc ggatggaggg caagtatttt tactatccag accaaggacc tgaacgcaag 300 catgcccatg ttttctttca ttttgaagat ggtggcacgc ttgtttatga ggatgttcgc 360 aagtttggaa ccatggaact cttggtgcct gaccttttag acgtctactt tatttctaaa 420 aaattaggtc ctgaaccaag cgaacaagac tttgatttac aggtctttca atctgccctt 480 gccaagtcca aaaagcctat caaatcccat ctcctagacc agaccttggt agctggactt 540 ggcaatatct atgtggatga ggttctctgg cgagctcagg ttcatccagc tagaccttcc 600 cagactttga cagcagaaga agcgactgcc attcatgacc agaccattgc tgttttgggc 660 caggctgttg aaaaaggtgg ctccaccatt cggacttata ccaatgcctt tggggaagat 720 ggaagcatgc aggactttca tcaggtctat gataagactg gtcaagaatg tgtacgctgt 780 ggtaccatca ttgagaaaat tcaactaggc ggacgtggaa cccacttttg tccaaactgt 840 caaaggaggg actga 855 62 284 PRT Streptococcus pneumoniae 62 Met Leu Leu Val Phe Thr Glu Gly Gly Leu Met Pro Glu Leu Pro Glu 1 5 10 15 Val Glu Thr Val Cys Arg Gly Leu Glu Lys Leu Ile Ile Gly Lys Lys 20 25 30 Ile Ser Ser Ile Glu Ile Arg Tyr Pro Lys Met Ile Lys Thr Asp Leu 35 40 45 Glu Glu Phe Gln Arg Glu Leu Pro Ser Gln Ile Ile Glu Ser Met Gly 50 55 60 Arg Arg Gly Lys Tyr Leu Leu Phe Tyr Leu Thr Asp Lys Val Leu Ile 65 70 75 80 Ser His Leu Arg Met Glu Gly Lys Tyr Phe Tyr Tyr Pro Asp Gln Gly 85 90 95 Pro Glu Arg Lys His Ala His Val Phe Phe His Phe Glu Asp Gly Gly 100 105 110 Thr Leu Val Tyr Glu Asp Val Arg Lys Phe Gly Thr Met Glu Leu Leu 115 120 125 Val Pro Asp Leu Leu Asp Val Tyr Phe Ile Ser Lys Lys Leu Gly Pro 130 135 140 Glu Pro Ser Glu Gln Asp Phe Asp Leu Gln Val Phe Gln Ser Ala Leu 145 150 155 160 Ala Lys Ser Lys Lys Pro Ile Lys Ser His Leu Leu Asp Gln Thr Leu 165 170 175 Val Ala Gly Leu Gly Asn Ile Tyr Val Asp Glu Val Leu Trp Arg Ala 180 185 190 Gln Val His Pro Ala Arg Pro Ser Gln Thr Leu Thr Ala Glu Glu Ala 195 200 205 Thr Ala Ile His Asp Gln Thr Ile Ala Val Leu Gly Gln Ala Val Glu 210 215 220 Lys Gly Gly Ser Thr Ile Arg Thr Tyr Thr Asn Ala Phe Gly Glu Asp 225 230 235 240 Gly Ser Met Gln Asp Phe His Gln Val Tyr Asp Lys Thr Gly Gln Glu 245 250 255 Cys Val Arg Cys Gly Thr Ile Ile Glu Lys Ile Gln Leu Gly Gly Arg 260 265 270 Gly Thr His Phe Cys Pro Asn Cys Gln Arg Arg Asp 275 280 63 633 DNA Streptococcus pneumoniae 63 ttgtccaaac tgtcaaagga gggactgatg ggaaaaatca tcggaatcac tgggggaatt 60 gcctctggta agtcaactgt gacaaatttt ctaagacagc aaggctttca agtagtggat 120 gccgacgcag tcgtccacca actacagaaa cctggtggtc gtctgtttga ggctctagta 180 cagcactttg ggcaagaaat cattcttgaa aacggagaac tcaatcgccc tctcctagct 240 agtctcatct tttcaaatcc tgatgaacga gaatggtcta agcaaattca aggggagatt 300 atccgtgagg aactggctac tttgagagaa cagttggctc agacagaaga gattttcttc 360 atggatattc ccctactttt tgagcaggac tacagcgatt ggtttgctga gacttggttg 420 gtctatgtgg accgagatgc ccaagtggaa cgcttaatga aaagggacca gttgtccaaa 480 gatgaagctg agtctcgtct ggcagcccag tggcctttag aaaaaaagaa agatttggcc 540 agccaggttc ttgataataa tggcaatcag aaccagcttc ttaatcaagt gcatatcctt 600 cttgagggag gtaggcaaga tgacagagat taa 633 64 210 PRT Streptococcus pneumoniae 64 Met Ser Lys Leu Ser Lys Glu Gly Leu Met Gly Lys Ile Ile Gly Ile 1 5 10 15 Thr Gly Gly Ile Ala Ser Gly Lys Ser Thr Val Thr Asn Phe Leu Arg 20 25 30 Gln Gln Gly Phe Gln Val Val Asp Ala Asp Ala Val Val His Gln Leu 35 40 45 Gln Lys Pro Gly Gly Arg Leu Phe Glu Ala Leu Val Gln His Phe Gly 50 55 60 Gln Glu Ile Ile Leu Glu Asn Gly Glu Leu Asn Arg Pro Leu Leu Ala 65 70 75 80 Ser Leu Ile Phe Ser Asn Pro Asp Glu Arg Glu Trp Ser Lys Gln Ile 85 90 95 Gln Gly Glu Ile Ile Arg Glu Glu Leu Ala Thr Leu Arg Glu Gln Leu 100 105 110 Ala Gln Thr Glu Glu Ile Phe Phe Met Asp Ile Pro Leu Leu Phe Glu 115 120 125 Gln Asp Tyr Ser Asp Trp Phe Ala Glu Thr Trp Leu Val Tyr Val Asp 130 135 140 Arg Asp Ala Gln Val Glu Arg Leu Met Lys Arg Asp Gln Leu Ser Lys 145 150 155 160 Asp Glu Ala Glu Ser Arg Leu Ala Ala Gln Trp Pro Leu Glu Lys Lys 165 170 175 Lys Asp Leu Ala Ser Gln Val Leu Asp Asn Asn Gly Asn Gln Asn Gln 180 185 190 Leu Leu Asn Gln Val His Ile Leu Leu Glu Gly Gly Arg Gln Asp Asp 195 200 205 Arg Asp 210 65 1269 DNA Streptococcus pneumoniae 65 ttgataataa tggcaatcag aaccagcttc ttaatcaagt gcatatcctt cttgagggag 60 gtaggcaaga tgacagagat taactggaag gataatctgc gcattgcctg gtttggtaat 120 tttctgacag gagccagtat ttctttggtt gtacctttta tgcccatctt cgtggaaaat 180 ctaggtgtag ggagtcagca agtcgctttt tatgcaggct tagcaatttc tgtctctgct 240 atttccgcgg cgctcttttc tcctatttgg ggtattcttg ctgacaaata cggccgaaaa 300 cccatgatga ttcgggcagg tcttgctatg actatcacta tgggaggctt ggcctttgtc 360 ccaaatatct attggttaat ctttcttcgt ttactaaacg gtgtatttgc aggttttgtt 420 cctaatgcaa cggcactgat agccagtcag gttccaaagg agaaatcagg ctctgcctta 480 ggtactttgt ctacaggcgt agttgcaggt actctaactg gtccctttat tggtggcttt 540 atcgcagaat tatttggcat tcgtacagtt ttcttactgg ttggtagttt tctattttta 600 gctgctattt tgactatttg ctttatcaag gaagattttc aaccagtagc caaggaaaag 660 gctattccaa caaaggaatt atttacctcg gttaaatatc cctatctttt gctcaatctc 720 tttttaacca gttttgtcat ccaattttca gctcaatcga ttggccctat tttggctctt 780 tatgtacgcg acttagggca gacagagaat cttctttttg tctctggttt gattgtgtcc 840 agtatgggct tttccagcat gatgagtgca ggagtcatgg gcaagctagg tgacaaggtg 900 ggcaatcatc gtctcttggt tgtcgcccag ttttattcag tcatcatcta tctcctctgt 960 gccaatgcct ctagccccct tcaactagga ctctatcgtt tcctctttgg attgggaacc 1020 ggtgccttga ttcccggggt taatgcccta ctcagcaaaa tgactcccaa agccggcatt 1080 tcgagggtct ttgccttcaa tcaggtattc ttttatctgg gaggtgttgt tggtcccatg 1140 gcaggttctg cagtagcagg tcaatttggc taccatgctg tcttttatgc gacaagcctt 1200 tgtgttgcct ttagttgtct ctttaacctg attcaatttc gaacattatt aaaagtaaag 1260 gaaatctag 1269 66 422 PRT Streptococcus pneumoniae 66 Met Ile Ile Met Ala Ile Arg Thr Ser Phe Leu Ile Lys Cys Ile Ser 1 5 10 15 Phe Leu Arg Glu Val Gly Lys Met Thr Glu Ile Asn Trp Lys Asp Asn 20 25 30 Leu Arg Ile Ala Trp Phe Gly Asn Phe Leu Thr Gly Ala Ser Ile Ser 35 40 45 Leu Val Val Pro Phe Met Pro Ile Phe Val Glu Asn Leu Gly Val Gly 50 55 60 Ser Gln Gln Val Ala Phe Tyr Ala Gly Leu Ala Ile Ser Val Ser Ala 65 70 75 80 Ile Ser Ala Ala Leu Phe Ser Pro Ile Trp Gly Ile Leu Ala Asp Lys 85 90 95 Tyr Gly Arg Lys Pro Met Met Ile Arg Ala Gly Leu Ala Met Thr Ile 100 105 110 Thr Met Gly Gly Leu Ala Phe Val Pro Asn Ile Tyr Trp Leu Ile Phe 115 120 125 Leu Arg Leu Leu Asn Gly Val Phe Ala Gly Phe Val Pro Asn Ala Thr 130 135 140 Ala Leu Ile Ala Ser Gln Val Pro Lys Glu Lys Ser Gly Ser Ala Leu 145 150 155 160 Gly Thr Leu Ser Thr Gly Val Val Ala Gly Thr Leu Thr Gly Pro Phe 165 170 175 Ile Gly Gly Phe Ile Ala Glu Leu Phe Gly Ile Arg Thr Val Phe Leu 180 185 190 Leu Val Gly Ser Phe Leu Phe Leu Ala Ala Ile Leu Thr Ile Cys Phe 195 200 205 Ile Lys Glu Asp Phe Gln Pro Val Ala Lys Glu Lys Ala Ile Pro Thr 210 215 220 Lys Glu Leu Phe Thr Ser Val Lys Tyr Pro Tyr Leu Leu Leu Asn Leu 225 230 235 240 Phe Leu Thr Ser Phe Val Ile Gln Phe Ser Ala Gln Ser Ile Gly Pro 245 250 255 Ile Leu Ala Leu Tyr Val Arg Asp Leu Gly Gln Thr Glu Asn Leu Leu 260 265 270 Phe Val Ser Gly Leu Ile Val Ser Ser Met Gly Phe Ser Ser Met Met 275 280 285 Ser Ala Gly Val Met Gly Lys Leu Gly Asp Lys Val Gly Asn His Arg 290 295 300 Leu Leu Val Val Ala Gln Phe Tyr Ser Val Ile Ile Tyr Leu Leu Cys 305 310 315 320 Ala Asn Ala Ser Ser Pro Leu Gln Leu Gly Leu Tyr Arg Phe Leu Phe 325 330 335 Gly Leu Gly Thr Gly Ala Leu Ile Pro Gly Val Asn Ala Leu Leu Ser 340 345 350 Lys Met Thr Pro Lys Ala Gly Ile Ser Arg Val Phe Ala Phe Asn Gln 355 360 365 Val Phe Phe Tyr Leu Gly Gly Val Val Gly Pro Met Ala Gly Ser Ala 370 375 380 Val Ala Gly Gln Phe Gly Tyr His Ala Val Phe Tyr Ala Thr Ser Leu 385 390 395 400 Cys Val Ala Phe Ser Cys Leu Phe Asn Leu Ile Gln Phe Arg Thr Leu 405 410 415 Leu Lys Val Lys Glu Ile 420 67 1311 DNA Streptococcus pneumoniae 67 atggccctac caactattgc cattgtagga cgtcccaatg ttgggaaatc aaccctattt 60 aatcggatcg ctggtgagcg aatctccatt gtagaagatg tcgaaggagt gacacgtgac 120 cgtatttatg caacgggtga gtggctcaat cgttctttta gcatgattga tacaggagga 180 attgatgatg tcgatgctcc tttcatggaa caaatcaagc accaggcaga aattgccatg 240 gaagaagcag atgttatcgt ttttgtcgtg tctggtaagg aaggaattac tgatgcagac 300 gaatacgtag ctcgtaagct ttataagacc cacaaaccag ttatcctcgc agtcaacaag 360 gtggacaacc ctgagatgag aaatgatata tatgatttct atgctctcgg tttgggtgaa 420 ccattgccta tctcatctgt ccatggaatc ggtacagggg atgtgctaga tgcgatcgta 480 gaaaatcttc caaatgaata tgaggaagaa aatccagatg tcattaagtt tagcttgatt 540 ggtcgtccta acgttggaaa atcaagcttg atcaatgcta tcttgggaga agaccgtgtt 600 attgctagtc ctgttgctgg aacaactcgt gatgccattg atacccactt tacagataca 660 gatggtcaag agtttaccat gattgatacg gctggtatgc gtaagtctgg taaggtttat 720 gaaaatactg agaaatactc tgttatgcgt gccatgcgtg ctattgaccg ttcagatgtg 780 gtcttgatgg tcatcaatgc ggaagaaggc attcgtgagt acgacaagcg tatcgcagga 840 tttgcccatg aagctggtaa agggatgatt atcgtggtca acaagtggga tacgcttgaa 900 aaagataacc acactatgaa aaactgggaa gaagatatcc gtgagcagtt ccaatacctg 960 ccttacgcac cgattatctt tgtatcagct ttaaccaagc aacgtctcca caaacttcct 1020 gagatgatta agcaaatcag cgaaagtcaa aatacacgta ttccatcagc tgtcttgaac 1080 gatgtcatca tggatgccat tgccatcaac ccaacaccga cagacaaagg aaaacgtctc 1140 aagattttct atgcgaccca agtggcaacc aaaccaccaa cctttgtcat ctttgtcaat 1200 gaagaagaac tcatgcactt ttcttacctg cgtttcttgg aaaatcaaat ccgcaaggcc 1260 tttgtttttg agggaacacc gattcatctc atcgcaagaa aacgcaaata a 1311 68 436 PRT Streptococcus pneumoniae 68 Met Ala Leu Pro Thr Ile Ala Ile Val Gly Arg Pro Asn Val Gly Lys 1 5 10 15 Ser Thr Leu Phe Asn Arg Ile Ala Gly Glu Arg Ile Ser Ile Val Glu 20 25 30 Asp Val Glu Gly Val Thr Arg Asp Arg Ile Tyr Ala Thr Gly Glu Trp 35 40 45 Leu Asn Arg Ser Phe Ser Met Ile Asp Thr Gly Gly Ile Asp Asp Val 50 55 60 Asp Ala Pro Phe Met Glu Gln Ile Lys His Gln Ala Glu Ile Ala Met 65 70 75 80 Glu Glu Ala Asp Val Ile Val Phe Val Val Ser Gly Lys Glu Gly Ile 85 90 95 Thr Asp Ala Asp Glu Tyr Val Ala Arg Lys Leu Tyr Lys Thr His Lys 100 105 110 Pro Val Ile Leu Ala Val Asn Lys Val Asp Asn Pro Glu Met Arg Asn 115 120 125 Asp Ile Tyr Asp Phe Tyr Ala Leu Gly Leu Gly Glu Pro Leu Pro Ile 130 135 140 Ser Ser Val His Gly Ile Gly Thr Gly Asp Val Leu Asp Ala Ile Val 145 150 155 160 Glu Asn Leu Pro Asn Glu Tyr Glu Glu Glu Asn Pro Asp Val Ile Lys 165 170 175 Phe Ser Leu Ile Gly Arg Pro Asn Val Gly Lys Ser Ser Leu Ile Asn 180 185 190 Ala Ile Leu Gly Glu Asp Arg Val Ile Ala Ser Pro Val Ala Gly Thr 195 200 205 Thr Arg Asp Ala Ile Asp Thr His Phe Thr Asp Thr Asp Gly Gln Glu 210 215 220 Phe Thr Met Ile Asp Thr Ala Gly Met Arg Lys Ser Gly Lys Val Tyr 225 230 235 240 Glu Asn Thr Glu Lys Tyr Ser Val Met Arg Ala Met Arg Ala Ile Asp 245 250 255 Arg Ser Asp Val Val Leu Met Val Ile Asn Ala Glu Glu Gly Ile Arg 260 265 270 Glu Tyr Asp Lys Arg Ile Ala Gly Phe Ala His Glu Ala Gly Lys Gly 275 280 285 Met Ile Ile Val Val Asn Lys Trp Asp Thr Leu Glu Lys Asp Asn His 290 295 300 Thr Met Lys Asn Trp Glu Glu Asp Ile Arg Glu Gln Phe Gln Tyr Leu 305 310 315 320 Pro Tyr Ala Pro Ile Ile Phe Val Ser Ala Leu Thr Lys Gln Arg Leu 325 330 335 His Lys Leu Pro Glu Met Ile Lys Gln Ile Ser Glu Ser Gln Asn Thr 340 345 350 Arg Ile Pro Ser Ala Val Leu Asn Asp Val Ile Met Asp Ala Ile Ala 355 360 365 Ile Asn Pro Thr Pro Thr Asp Lys Gly Lys Arg Leu Lys Ile Phe Tyr 370 375 380 Ala Thr Gln Val Ala Thr Lys Pro Pro Thr Phe Val Ile Phe Val Asn 385 390 395 400 Glu Glu Glu Leu Met His Phe Ser Tyr Leu Arg Phe Leu Glu Asn Gln 405 410 415 Ile Arg Lys Ala Phe Val Phe Glu Gly Thr Pro Ile His Leu Ile Ala 420 425 430 Arg Lys Arg Lys 435 69 714 DNA Streptococcus pneumoniae 69 atgacagaaa ccattaaatt gatgaaggct catacttcag tgcgcaggtt taaagagcaa 60 gaaattcccc aagtagactt aaatgagatt ttgacagcag cccagatggc atcatcttgg 120 aagaatttcc aatcctactc tgtgattgtg gtacgaagtc aagagaagaa agatgccttg 180 tatgaattgg tacctcaaga agccattcgc cagtctgctg ttttccttct ctttgtcgga 240 gatttgaacc gagcagaaaa gggagcccga cttcataccg acaccttcca accccaaggt 300 gtggaaggtc tcttgattag ttcggtcgat gcagctcttg ctggacaaaa cgccttgttg 360 gcagctgaaa gcttgggcta tggtggtgtg attatcggtt tggttcgata caagtctgaa 420 gaagtggcag agctctttaa cctacctgac tacacctatt ctgtctttgg gatggcactg 480 ggtgtgccaa atcaacatca tgatatgaaa ccgagactgc cactagagaa tgttgtcttt 540 gaggaagaat accaagaaca gtcaactgag gcaatccaag cttatgaccg tgttcaggct 600 gactatgctg gggcgcgtgc gaccacaagc tggagtcagc gcctagcaga acagtttggt 660 caagctgaac caagctcaac tagaaaaaat cttgaacaga agaaattatt gtag 714 70 237 PRT Streptococcus pneumoniae 70 Met Thr Glu Thr Ile Lys Leu Met Lys Ala His Thr Ser Val Arg Arg 1 5 10 15 Phe Lys Glu Gln Glu Ile Pro Gln Val Asp Leu Asn Glu Ile Leu Thr 20 25 30 Ala Ala Gln Met Ala Ser Ser Trp Lys Asn Phe Gln Ser Tyr Ser Val 35 40 45 Ile Val Val Arg Ser Gln Glu Lys Lys Asp Ala Leu Tyr Glu Leu Val 50 55 60 Pro Gln Glu Ala Ile Arg Gln Ser Ala Val Phe Leu Leu Phe Val Gly 65 70 75 80 Asp Leu Asn Arg Ala Glu Lys Gly Ala Arg Leu His Thr Asp Thr Phe 85 90 95 Gln Pro Gln Gly Val Glu Gly Leu Leu Ile Ser Ser Val Asp Ala Ala 100 105 110 Leu Ala Gly Gln Asn Ala Leu Leu Ala Ala Glu Ser Leu Gly Tyr Gly 115 120 125 Gly Val Ile Ile Gly Leu Val Arg Tyr Lys Ser Glu Glu Val Ala Glu 130 135 140 Leu Phe Asn Leu Pro Asp Tyr Thr Tyr Ser Val Phe Gly Met Ala Leu 145 150 155 160 Gly Val Pro Asn Gln His His Asp Met Lys Pro Arg Leu Pro Leu Glu 165 170 175 Asn Val Val Phe Glu Glu Glu Tyr Gln Glu Gln Ser Thr Glu Ala Ile 180 185 190 Gln Ala Tyr Asp Arg Val Gln Ala Asp Tyr Ala Gly Ala Arg Ala Thr 195 200 205 Thr Ser Trp Ser Gln Arg Leu Ala Glu Gln Phe Gly Gln Ala Glu Pro 210 215 220 Ser Ser Thr Arg Lys Asn Leu Glu Gln Lys Lys Leu Leu 225 230 235 71 729 DNA Streptococcus pneumoniae 71 atgacagaaa ttagactaga gcacgtcagt tatgcctatg gtcaggagag gattttagag 60 gatatcaacc tacaggtgac ttcaggcgaa gtggtttcca tcctaggccc aagtggtgtt 120 ggaaagacca ccctctttaa tctaatcgct gggattttag aagttcagtc agggagaatt 180 gtccttgatg gtgaagaaaa tcccaagggg cgcgtgagtt atatgttgca aaaggatctg 240 ctcttggagc acaagacggt gcttggaaat atcattctgc ccctcttgat tcaaaaggtg 300 gataaggcag aagctatttc ccgagcggat aaaattcttg cgaccttcca gctgacagct 360 gtaagagaca agtatcctca tgaacttagc ggtgggatgc gccagcgtgt agccttactc 420 cggacctacc tttttgggca caagctcttt ctcttagatg aggcctttag cgccttggat 480 gagatgacaa agatggaact ccacgcttgg tatcttgaga ttcacaagca gttgcagcta 540 acaaccctga tcatcacgca tagtattgag gaggccctca atctcagcga ccgtatctat 600 atcttgaaaa atcgccctgg gcagattgtt tcagaaatta aactagattg gtctgaagat 660 gaggacaagg aagtccaaaa gattgcctac aaacgtcaaa ttttggcgga attaggctta 720 gataagtag 729 72 242 PRT Streptococcus pneumoniae 72 Met Thr Glu Ile Arg Leu Glu His Val Ser Tyr Ala Tyr Gly Gln Glu 1 5 10 15 Arg Ile Leu Glu Asp Ile Asn Leu Gln Val Thr Ser Gly Glu Val Val 20 25 30 Ser Ile Leu Gly Pro Ser Gly Val Gly Lys Thr Thr Leu Phe Asn Leu 35 40 45 Ile Ala Gly Ile Leu Glu Val Gln Ser Gly Arg Ile Val Leu Asp Gly 50 55 60 Glu Glu Asn Pro Lys Gly Arg Val Ser Tyr Met Leu Gln Lys Asp Leu 65 70 75 80 Leu Leu Glu His Lys Thr Val Leu Gly Asn Ile Ile Leu Pro Leu Leu 85 90 95 Ile Gln Lys Val Asp Lys Ala Glu Ala Ile Ser Arg Ala Asp Lys Ile 100 105 110 Leu Ala Thr Phe Gln Leu Thr Ala Val Arg Asp Lys Tyr Pro His Glu 115 120 125 Leu Ser Gly Gly Met Arg Gln Arg Val Ala Leu Leu Arg Thr Tyr Leu 130 135 140 Phe Gly His Lys Leu Phe Leu Leu Asp Glu Ala Phe Ser Ala Leu Asp 145 150 155 160 Glu Met Thr Lys Met Glu Leu His Ala Trp Tyr Leu Glu Ile His Lys 165 170 175 Gln Leu Gln Leu Thr Thr Leu Ile Ile Thr His Ser Ile Glu Glu Ala 180 185 190 Leu Asn Leu Ser Asp Arg Ile Tyr Ile Leu Lys Asn Arg Pro Gly Gln 195 200 205 Ile Val Ser Glu Ile Lys Leu Asp Trp Ser Glu Asp Glu Asp Lys Glu 210 215 220 Val Gln Lys Ile Ala Tyr Lys Arg Gln Ile Leu Ala Glu Leu Gly Leu 225 230 235 240 Asp Lys 73 2433 DNA Streptococcus pneumoniae 73 atgaactatt caaaagcatt gaatgaatgt atcgaaagtg cctacatggt tgctggacat 60 tttggagctc gttatctaga gtcgtggcac ttgttgattg ccatgtctaa tcacagttat 120 agtgtagcag gggcaacttt aaatgattat ccgtatgaga tggaccgttt agaagaggtg 180 gctttggaac tgactgaaac ggactatagc caggatgaaa cctttacgga attgccgttc 240 tcccgtcgtt tgcaggttct ttttgatgaa gcagagtatg tagcgtcagt ggtccatgct 300 aaggtactag ggacagagca cgtcctctat gcgattttgc atgatagcaa tgccttggcg 360 actcgtatct tggagagggc tggtttttct tatgaagaca agaaagatca ggtcaagatt 420 gctgctcttc gtcgaaattt agaagaacgg gcaggctgga ctcgtgaaga tctcaaggct 480 ttacgccaac gccatcgtac agtagctgac aagcaaaatt ctatggccaa tatgatgggc 540 atgccgcaga ctcctagtgg tggtctcgag gattatacgc atgatttgac agagcaagcg 600 cgttctggca agttagaacc agtcatcggt cgggacaagg aaatctcacg tatgattcaa 660 atcttgagcc ggaagactaa gaacaaccct gtcttggttg gggatgctgg tgtcgggaaa 720 acagctctgg cgcttggtct tgcccagcgt attgctagtg gtgacgtgcc tgcggaaatg 780 gctaagatgc gcgtgttaga acttgatttg atgaatgtcg ttgcagggac acgcttccgt 840 ggtgactttg aagaacgcat gaataatatc atcaaggata ttgaagaaga tggccaagtc 900 atcctcttta tcgatgaact ccacaccatc atgggttctg gtagcgggat tgattcgact 960 ctggatgcgg ccaatatctt gaaaccagcc ttggcgcgtg gaactttgag aacggttggt 1020 gccactactc aggaagaata tcaaaaacat atcgaaaaag atgcggcact ttctcgtcgt 1080 ttcgctaaag tgacgattga agaaccaagt gtggcagata gtatgactat tttacaaggt 1140 ttgaaggcga cttatgagaa acatcaccgt gtacaaatca cagatgaagc ggttgaaaca 1200 gcggttaaga tggctcatcg ttatttaacc agtcgtcact tgccagactc tgctatcgat 1260 ctcttggatg aggcggcagc aacagtgcaa aataaggcaa agcatgtaaa agcagacgat 1320 tcagatttga gtccagctga caaggccctg atggatggca agtggaaaca ggcagcccag 1380 ctaatcgcaa aagaagagga agtacctgtc tacaaagact tggtgacaga gtctgatatt 1440 ttgaccacct tgagtcgctt gtcaggaatc ccagttcaaa aactgactca aacggatgct 1500 aagaagtatt taaatcttga agcagaactc cataaacggg ttatcggtca agatcaagct 1560 gtttcaagca ttagccgtgc cattcgccgc aaccagtcag ggattcgcag tcataagcgt 1620 ccgattggtt cctttatgtt cctagggcct acaggtgtcg ggaaaactga attagccaag 1680 gctctggcag aagttctttt tgacgacgaa tcagccctta tccgctttga tatgagtgag 1740 tatatggaga aatttgcagc tagtcgtctc aacggagctc ctccaggcta tgtaggatat 1800 gaagaaggtg gggagttgac agagaaggtt cgcaataaac cctattccgt tctcctcttt 1860 gatgaggtag agaaggccca cccagatatc tttaatgttc tcttgcaggt tctggatgac 1920 ggtgtcttga cagatagcaa gggacgcaag gtcgattttt caaataccat tatcattatg 1980 acatcgaatc taggtgcgac tgcccttcgt gatgataaga ctgttggttt tggggctaag 2040 gatattcgtt ttgaccagga aaatatggaa aaacgcatgt ttgaagaact gaaaaaagct 2100 tatagaccgg aattcatcaa ccgtattgat gagaaggtgg tcttccatag cctatctagt 2160 gatcatatgc aggaagtggt gaagattatg gtcaagcctt tagtggcaag tttgactgaa 2220 aaaggcattg acttgaaatt acaagcttca gctctgaaat tgttagcaaa tcaaggatat 2280 gacccagaga tgggagctcg cccacttcgc agaaccctgc aaacagaagt ggaggacaag 2340 ttggcagaac ttcttctcaa gggagattta gtggcaggca gcacacttaa gattggtgtc 2400 aaagcaggcc agttaaaatt tgatattgca taa 2433 74 810 PRT Streptococcus pneumoniae 74 Met Asn Tyr Ser Lys Ala Leu Asn Glu Cys Ile Glu Ser Ala Tyr Met 1 5 10 15 Val Ala Gly His Phe Gly Ala Arg Tyr Leu Glu Ser Trp His Leu Leu 20 25 30 Ile Ala Met Ser Asn His Ser Tyr Ser Val Ala Gly Ala Thr Leu Asn 35 40 45 Asp Tyr Pro Tyr Glu Met Asp Arg Leu Glu Glu Val Ala Leu Glu Leu 50 55 60 Thr Glu Thr Asp Tyr Ser Gln Asp Glu Thr Phe Thr Glu Leu Pro Phe 65 70 75 80 Ser Arg Arg Leu Gln Val Leu Phe Asp Glu Ala Glu Tyr Val Ala Ser 85 90 95 Val Val His Ala Lys Val Leu Gly Thr Glu His Val Leu Tyr Ala Ile 100 105 110 Leu His Asp Ser Asn Ala Leu Ala Thr Arg Ile Leu Glu Arg Ala Gly 115 120 125 Phe Ser Tyr Glu Asp Lys Lys Asp Gln Val Lys Ile Ala Ala Leu Arg 130 135 140 Arg Asn Leu Glu Glu Arg Ala Gly Trp Thr Arg Glu Asp Leu Lys Ala 145 150 155 160 Leu Arg Gln Arg His Arg Thr Val Ala Asp Lys Gln Asn Ser Met Ala 165 170 175 Asn Met Met Gly Met Pro Gln Thr Pro Ser Gly Gly Leu Glu Asp Tyr 180 185 190 Thr His Asp Leu Thr Glu Gln Ala Arg Ser Gly Lys Leu Glu Pro Val 195 200 205 Ile Gly Arg Asp Lys Glu Ile Ser Arg Met Ile Gln Ile Leu Ser Arg 210 215 220 Lys Thr Lys Asn Asn Pro Val Leu Val Gly Asp Ala Gly Val Gly Lys 225 230 235 240 Thr Ala Leu Ala Leu Gly Leu Ala Gln Arg Ile Ala Ser Gly Asp Val 245 250 255 Pro Ala Glu Met Ala Lys Met Arg Val Leu Glu Leu Asp Leu Met Asn 260 265 270 Val Val Ala Gly Thr Arg Phe Arg Gly Asp Phe Glu Glu Arg Met Asn 275 280 285 Asn Ile Ile Lys Asp Ile Glu Glu Asp Gly Gln Val Ile Leu Phe Ile 290 295 300 Asp Glu Leu His Thr Ile Met Gly Ser Gly Ser Gly Ile Asp Ser Thr 305 310 315 320 Leu Asp Ala Ala Asn Ile Leu Lys Pro Ala Leu Ala Arg Gly Thr Leu 325 330 335 Arg Thr Val Gly Ala Thr Thr Gln Glu Glu Tyr Gln Lys His Ile Glu 340 345 350 Lys Asp Ala Ala Leu Ser Arg Arg Phe Ala Lys Val Thr Ile Glu Glu 355 360 365 Pro Ser Val Ala Asp Ser Met Thr Ile Leu Gln Gly Leu Lys Ala Thr 370 375 380 Tyr Glu Lys His His Arg Val Gln Ile Thr Asp Glu Ala Val Glu Thr 385 390 395 400 Ala Val Lys Met Ala His Arg Tyr Leu Thr Ser Arg His Leu Pro Asp 405 410 415 Ser Ala Ile Asp Leu Leu Asp Glu Ala Ala Ala Thr Val Gln Asn Lys 420 425 430 Ala Lys His Val Lys Ala Asp Asp Ser Asp Leu Ser Pro Ala Asp Lys 435 440 445 Ala Leu Met Asp Gly Lys Trp Lys Gln Ala Ala Gln Leu Ile Ala Lys 450 455 460 Glu Glu Glu Val Pro Val Tyr Lys Asp Leu Val Thr Glu Ser Asp Ile 465 470 475 480 Leu Thr Thr Leu Ser Arg Leu Ser Gly Ile Pro Val Gln Lys Leu Thr 485 490 495 Gln Thr Asp Ala Lys Lys Tyr Leu Asn Leu Glu Ala Glu Leu His Lys 500 505 510 Arg Val Ile Gly Gln Asp Gln Ala Val Ser Ser Ile Ser Arg Ala Ile 515 520 525 Arg Arg Asn Gln Ser Gly Ile Arg Ser His Lys Arg Pro Ile Gly Ser 530 535 540 Phe Met Phe Leu Gly Pro Thr Gly Val Gly Lys Thr Glu Leu Ala Lys 545 550 555 560 Ala Leu Ala Glu Val Leu Phe Asp Asp Glu Ser Ala Leu Ile Arg Phe 565 570 575 Asp Met Ser Glu Tyr Met Glu Lys Phe Ala Ala Ser Arg Leu Asn Gly 580 585 590 Ala Pro Pro Gly Tyr Val Gly Tyr Glu Glu Gly Gly Glu Leu Thr Glu 595 600 605 Lys Val Arg Asn Lys Pro Tyr Ser Val Leu Leu Phe Asp Glu Val Glu 610 615 620 Lys Ala His Pro Asp Ile Phe Asn Val Leu Leu Gln Val Leu Asp Asp 625 630 635 640 Gly Val Leu Thr Asp Ser Lys Gly Arg Lys Val Asp Phe Ser Asn Thr 645 650 655 Ile Ile Ile Met Thr Ser Asn Leu Gly Ala Thr Ala Leu Arg Asp Asp 660 665 670 Lys Thr Val Gly Phe Gly Ala Lys Asp Ile Arg Phe Asp Gln Glu Asn 675 680 685 Met Glu Lys Arg Met Phe Glu Glu Leu Lys Lys Ala Tyr Arg Pro Glu 690 695 700 Phe Ile Asn Arg Ile Asp Glu Lys Val Val Phe His Ser Leu Ser Ser 705 710 715 720 Asp His Met Gln Glu Val Val Lys Ile Met Val Lys Pro Leu Val Ala 725 730 735 Ser Leu Thr Glu Lys Gly Ile Asp Leu Lys Leu Gln Ala Ser Ala Leu 740 745 750 Lys Leu Leu Ala Asn Gln Gly Tyr Asp Pro Glu Met Gly Ala Arg Pro 755 760 765 Leu Arg Arg Thr Leu Gln Thr Glu Val Glu Asp Lys Leu Ala Glu Leu 770 775 780 Leu Leu Lys Gly Asp Leu Val Ala Gly Ser Thr Leu Lys Ile Gly Val 785 790 795 800 Lys Ala Gly Gln Leu Lys Phe Asp Ile Ala 805 810 75 1008 DNA Streptococcus pneumoniae 75 atgaagaaaa catggaaagt gtttttaacg cttgtaacag ctcttgtagc tgttgtgctt 60 gtggcctgtg gtcaaggaac tgcttctaaa gacaacaaag aggcagaact taagaaggtt 120 gactttatcc tagactggac accaaatacc aaccacacag ggctttatgt tgccaaggaa 180 aaaggttatt tcaaagaagc tggagtggat gttgatttga aattgccacc agaagaaagt 240 tcttctgact tggttatcaa cggaaaggca ccatttgcag tgtatttcca agactacatg 300 gctaagaaat tggaaaaagg agcaggaatc actgccgttg cagctattgt tgaacacaat 360 acatcaggaa tcatctctcg taaatctgat aatgtaagca gtccaaaaga cttggttggt 420 aagaaatatg ggacatggaa tgacccaact gaacttgcta tgttgaaaac cttggtagaa 480 tctcaaggtg gagactttga gaaggttgaa aaagtaccaa ataacgactc aaactcaatc 540 acaccgattg ccaatggcgt ctttgatact gcttggattt actacggttg ggatggtatc 600 cttgctaaat ctcaaggtgt agatgctaac ttcatgtact tgaaagacta tgtcaaggag 660 tttgactact attcaccagt tatcatcgca aacaacgact atctgaaaga taacaaagaa 720 gaagctcgca aagtcatcca agccatcaaa aaaggctacc aatatgccat ggaacatcca 780 gaagaagctg cagatattct catcaagaat gcacctgaac tcaaggaaaa acgtgacttt 840 gtcatcgaat ctcaaaaata cttgtcaaaa gaatacgcaa gcgacaagga aaaatggggt 900 caatttgacg cagctcgctg gaatgctttc tacaaatggg ataaagaaaa tggtatcctt 960 aaagaagact tgacagacaa aggcttcacc aacgaatttg tgaaataa 1008 76 335 PRT Streptococcus pneumoniae 76 Met Lys Lys Thr Trp Lys Val Phe Leu Thr Leu Val Thr Ala Leu Val 1 5 10 15 Ala Val Val Leu Val Ala Cys Gly Gln Gly Thr Ala Ser Lys Asp Asn 20 25 30 Lys Glu Ala Glu Leu Lys Lys Val Asp Phe Ile Leu Asp Trp Thr Pro 35 40 45 Asn Thr Asn His Thr Gly Leu Tyr Val Ala Lys Glu Lys Gly Tyr Phe 50 55 60 Lys Glu Ala Gly Val Asp Val Asp Leu Lys Leu Pro Pro Glu Glu Ser 65 70 75 80 Ser Ser Asp Leu Val Ile Asn Gly Lys Ala Pro Phe Ala Val Tyr Phe 85 90 95 Gln Asp Tyr Met Ala Lys Lys Leu Glu Lys Gly Ala Gly Ile Thr Ala 100 105 110 Val Ala Ala Ile Val Glu His Asn Thr Ser Gly Ile Ile Ser Arg Lys 115 120 125 Ser Asp Asn Val Ser Ser Pro Lys Asp Leu Val Gly Lys Lys Tyr Gly 130 135 140 Thr Trp Asn Asp Pro Thr Glu Leu Ala Met Leu Lys Thr Leu Val Glu 145 150 155 160 Ser Gln Gly Gly Asp Phe Glu Lys Val Glu Lys Val Pro Asn Asn Asp 165 170 175 Ser Asn Ser Ile Thr Pro Ile Ala Asn Gly Val Phe Asp Thr Ala Trp 180 185 190 Ile Tyr Tyr Gly Trp Asp Gly Ile Leu Ala Lys Ser Gln Gly Val Asp 195 200 205 Ala Asn Phe Met Tyr Leu Lys Asp Tyr Val Lys Glu Phe Asp Tyr Tyr 210 215 220 Ser Pro Val Ile Ile Ala Asn Asn Asp Tyr Leu Lys Asp Asn Lys Glu 225 230 235 240 Glu Ala Arg Lys Val Ile Gln Ala Ile Lys Lys Gly Tyr Gln Tyr Ala 245 250 255 Met Glu His Pro Glu Glu Ala Ala Asp Ile Leu Ile Lys Asn Ala Pro 260 265 270 Glu Leu Lys Glu Lys Arg Asp Phe Val Ile Glu Ser Gln Lys Tyr Leu 275 280 285 Ser Lys Glu Tyr Ala Ser Asp Lys Glu Lys Trp Gly Gln Phe Asp Ala 290 295 300 Ala Arg Trp Asn Ala Phe Tyr Lys Trp Asp Lys Glu Asn Gly Ile Leu 305 310 315 320 Lys Glu Asp Leu Thr Asp Lys Gly Phe Thr Asn Glu Phe Val Lys 325 330 335 77 762 DNA Streptococcus pneumoniae 77 ttgatgagaa acttgagaag tatactgaga cgacacatta gtctattggg ctttctcgga 60 gtattgtcaa tctggcagtt agcaggtttt cttaaacttc tccccaagtt tatcctgccg 120 acacctcttg aaattctcca gccctttgtt cgtgacagag aatttctctg gcaccatagc 180 tgggcgacct tgagagtggc tttactgggg ctgattttgg gagttttgat tgcctgtctt 240 atggctgtgc tcatggatag tttgacttgg ctcaatgacc tgatttaccc tatgatggtg 300 gtcattcaga ccattccgac cattgccata gctcctatcc tggtcttgtg gctaggttat 360 gggattttgc ccaagattgt cttgattatc ttaacgacaa cctttcccat catcgttagt 420 attttggacg gttttaggca ttgcgacaag gatatgctga ccttgtttag tctgatgcgg 480 gccaagcctt ggcaaatcct gtggcatttt aaaatcccag ttagcctgcc ttacttttat 540 gcaggtctga gggtcagtgt ctcctacgcc tttatcacaa ctgtggtatc tgagtggttg 600 ggaggttttg aaggtcttgg tgtttatatg attcagtcta aaaaactgtt tcagtatgat 660 accatgtttg ccattattat tctggtgtcg attatcagtc ttttgggtat gaagctggtc 720 gatatcagtg aaaaatatgt gattaaatgg aaacgttcgt ag 762 78 253 PRT Streptococcus pneumoniae 78 Met Met Arg Asn Leu Arg Ser Ile Leu Arg Arg His Ile Ser Leu Leu 1 5 10 15 Gly Phe Leu Gly Val Leu Ser Ile Trp Gln Leu Ala Gly Phe Leu Lys 20 25 30 Leu Leu Pro Lys Phe Ile Leu Pro Thr Pro Leu Glu Ile Leu Gln Pro 35 40 45 Phe Val Arg Asp Arg Glu Phe Leu Trp His His Ser Trp Ala Thr Leu 50 55 60 Arg Val Ala Leu Leu Gly Leu Ile Leu Gly Val Leu Ile Ala Cys Leu 65 70 75 80 Met Ala Val Leu Met Asp Ser Leu Thr Trp Leu Asn Asp Leu Ile Tyr 85 90 95 Pro Met Met Val Val Ile Gln Thr Ile Pro Thr Ile Ala Ile Ala Pro 100 105 110 Ile Leu Val Leu Trp Leu Gly Tyr Gly Ile Leu Pro Lys Ile Val Leu 115 120 125 Ile Ile Leu Thr Thr Thr Phe Pro Ile Ile Val Ser Ile Leu Asp Gly 130 135 140 Phe Arg His Cys Asp Lys Asp Met Leu Thr Leu Phe Ser Leu Met Arg 145 150 155 160 Ala Lys Pro Trp Gln Ile Leu Trp His Phe Lys Ile Pro Val Ser Leu 165 170 175 Pro Tyr Phe Tyr Ala Gly Leu Arg Val Ser Val Ser Tyr Ala Phe Ile 180 185 190 Thr Thr Val Val Ser Glu Trp Leu Gly Gly Phe Glu Gly Leu Gly Val 195 200 205 Tyr Met Ile Gln Ser Lys Lys Leu Phe Gln Tyr Asp Thr Met Phe Ala 210 215 220 Ile Ile Ile Leu Val Ser Ile Ile Ser Leu Leu Gly Met Lys Leu Val 225 230 235 240 Asp Ile Ser Glu Lys Tyr Val Ile Lys Trp Lys Arg Ser 245 250 79 372 DNA Streptococcus pneumoniae 79 ttgattttta atcctatttg ctgtatgata agggaaaaga aaggggacag agatatggct 60 tttaccaata cccacatgcg atctgctagt tttggtattg ttaccagctt gcctgatgac 120 atcattgact ctttttggta tatcatcgac catttcttaa aaaatgtctt tgaattggaa 180 gaagaactcg agtttcaatt gcttaataac caaggaaaga ttaccttcca cttttcaagt 240 caacacctcc ctacagccat tgattttgac tttaaccatc ctttcgaccc tcgttatccc 300 ccaagagtac tggttttaga catggacggt agagaaacta tcctcctccc agaagaaaat 360 gacctatttt aa 372 80 123 PRT Streptococcus pneumoniae 80 Met Ile Phe Asn Pro Ile Cys Cys Met Ile Arg Glu Lys Lys Gly Asp 1 5 10 15 Arg Asp Met Ala Phe Thr Asn Thr His Met Arg Ser Ala Ser Phe Gly 20 25 30 Ile Val Thr Ser Leu Pro Asp Asp Ile Ile Asp Ser Phe Trp Tyr Ile 35 40 45 Ile Asp His Phe Leu Lys Asn Val Phe Glu Leu Glu Glu Glu Leu Glu 50 55 60 Phe Gln Leu Leu Asn Asn Gln Gly Lys Ile Thr Phe His Phe Ser Ser 65 70 75 80 Gln His Leu Pro Thr Ala Ile Asp Phe Asp Phe Asn His Pro Phe Asp 85 90 95 Pro Arg Tyr Pro Pro Arg Val Leu Val Leu Asp Met Asp Gly Arg Glu 100 105 110 Thr Ile Leu Leu Pro Glu Glu Asn Asp Leu Phe 115 120 81 1645 DNA Streptococcus pneumoniae 81 acagcggtgt cattctatct attttaagaa aagtaataat caattgttaa aaatagtaaa 60 aaaattggag gttctgatga aatattttgt tcctaatgag gtattcagta ttcgtaaatt 120 aaaggtgggg acttgctcgg tactattggc aatttcaatt ttgggaagcc aaggtatttt 180 atcggatgaa gttgttacta gttcttcacc gatggctaca aaagagtctt ctaatgcaat 240 tactaatgat ttagataatt caccaactgt taatcagaat cgttctgctg aaatgattgc 300 ctctaattca accactaatg gtttagataa ttcgttaagt gttaatagca tcagctctaa 360 tggtactatt cgttccaatt cacaattaga caacagaaca gttgaatcta cagtaacatc 420 tactaatgaa aataagagtt ataaggaaga tgttataagt gacagaatta tcaaaaaaga 480 atttgaagat actgctttaa gtgtaaaaga ttatggtgca gtaggtgatg ggattcatga 540 tgatcgacaa gcaattcaag atgcaataga tgctgcagct caagggctag gtggaggaaa 600 tgtatatttt cctgaaggaa cttatttagt aaaagaaatt gtttttttaa aaagtcatac 660 acacttagaa ttgaatgaga aagctacaat tctaaatggt ataaatatta agaatcaccc 720 ttccattgtt tttatgacag gtttatttac ggatgatggt gcgcaagtag aatggggccc 780 aacagaagat attagttatt ctggtggtac gattgatatg aacggtgctt tgaatgaaga 840 aggaactaaa gcaaaaaatc taccacttat aaattcttca ggtgcatttg ctattgggaa 900 ttcaaataac gtaactataa aaaatgtaac attcaaggat agttatcaag ggcatgctat 960 tcaaattgca ggttcgaaaa atgtattagt tgataattct cgttttcttg ggcaagcctt 1020 acccaaaacg atgaaggatg ggcaaatcat aagtaaggag agcattcaga ttgaaccatt 1080 aactagaaaa ggttttcctt atgccttgaa tgatgatggg aaaaaatctg aaaatgtgac 1140 tattcaaaat tcctattttg gcaaaagtga taaatctggg gaattagtaa cagcaattgg 1200 cacacactat caaacattgt cgacacagaa cccctctaat attaaaattc aaaataatca 1260 ttttgataac atgatgtatg caggtgtacg ttttacagga ttcactgatg tattaatcaa 1320 aggaaatcgc tttgataaga aagttaaagg agagagtgta cattatcgag aaagcggagc 1380 agctttagta aatgcttata gctataaaaa cactaaagac ctattagatt taaataaaca 1440 ggtggttatc gccgaaaata tatttaatat tgccgatcct aaaacaaaag cgatacgagt 1500 tgcaaaagat agtgcagaat gtttaggaaa agtatcagat attactgtaa caaaaaatgt 1560 aattaataat aattctaagg aaacagaaca accaaatatt gaattattac gagttagtga 1620 taatttagta gtctcagaga atagt 1645 82 548 PRT Streptococcus pneumoniae 82 Gln Arg Cys His Ser Ile Tyr Phe Lys Lys Ser Asn Asn Gln Leu Leu 1 5 10 15 Lys Ile Val Lys Lys Leu Glu Val Leu Met Lys Tyr Phe Val Pro Asn 20 25 30 Glu Val Phe Ser Ile Arg Lys Leu Lys Val Gly Thr Cys Ser Val Leu 35 40 45 Leu Ala Ile Ser Ile Leu Gly Ser Gln Gly Ile Leu Ser Asp Glu Val 50 55 60 Val Thr Ser Ser Ser Pro Met Ala Thr Lys Glu Ser Ser Asn Ala Ile 65 70 75 80 Thr Asn Asp Leu Asp Asn Ser Pro Thr Val Asn Gln Asn Arg Ser Ala 85 90 95 Glu Met Ile Ala Ser Asn Ser Thr Thr Asn Gly Leu Asp Asn Ser Leu 100 105 110 Ser Val Asn Ser Ile Ser Ser Asn Gly Thr Ile Arg Ser Asn Ser Gln 115 120 125 Leu Asp Asn Arg Thr Val Glu Ser Thr Val Thr Ser Thr Asn Glu Asn 130 135 140 Lys Ser Tyr Lys Glu Asp Val Ile Ser Asp Arg Ile Ile Lys Lys Glu 145 150 155 160 Phe Glu Asp Thr Ala Leu Ser Val Lys Asp Tyr Gly Ala Val Gly Asp 165 170 175 Gly Ile His Asp Asp Arg Gln Ala Ile Gln Asp Ala Ile Asp Ala Ala 180 185 190 Ala Gln Gly Leu Gly Gly Gly Asn Val Tyr Phe Pro Glu Gly Thr Tyr 195 200 205 Leu Val Lys Glu Ile Val Phe Leu Lys Ser His Thr His Leu Glu Leu 210 215 220 Asn Glu Lys Ala Thr Ile Leu Asn Gly Ile Asn Ile Lys Asn His Pro 225 230 235 240 Ser Ile Val Phe Met Thr Gly Leu Phe Thr Asp Asp Gly Ala Gln Val 245 250 255 Glu Trp Gly Pro Thr Glu Asp Ile Ser Tyr Ser Gly Gly Thr Ile Asp 260 265 270 Met Asn Gly Ala Leu Asn Glu Glu Gly Thr Lys Ala Lys Asn Leu Pro 275 280 285 Leu Ile Asn Ser Ser Gly Ala Phe Ala Ile Gly Asn Ser Asn Asn Val 290 295 300 Thr Ile Lys Asn Val Thr Phe Lys Asp Ser Tyr Gln Gly His Ala Ile 305 310 315 320 Gln Ile Ala Gly Ser Lys Asn Val Leu Val Asp Asn Ser Arg Phe Leu 325 330 335 Gly Gln Ala Leu Pro Lys Thr Met Lys Asp Gly Gln Ile Ile Ser Lys 340 345 350 Glu Ser Ile Gln Ile Glu Pro Leu Thr Arg Lys Gly Phe Pro Tyr Ala 355 360 365 Leu Asn Asp Asp Gly Lys Lys Ser Glu Asn Val Thr Ile Gln Asn Ser 370 375 380 Tyr Phe Gly Lys Ser Asp Lys Ser Gly Glu Leu Val Thr Ala Ile Gly 385 390 395 400 Thr His Tyr Gln Thr Leu Ser Thr Gln Asn Pro Ser Asn Ile Lys Ile 405 410 415 Gln Asn Asn His Phe Asp Asn Met Met Tyr Ala Gly Val Arg Phe Thr 420 425 430 Gly Phe Thr Asp Val Leu Ile Lys Gly Asn Arg Phe Asp Lys Lys Val 435 440 445 Lys Gly Glu Ser Val His Tyr Arg Glu Ser Gly Ala Ala Leu Val Asn 450 455 460 Ala Tyr Ser Tyr Lys Asn Thr Lys Asp Leu Leu Asp Leu Asn Lys Gln 465 470 475 480 Val Val Ile Ala Glu Asn Ile Phe Asn Ile Ala Asp Pro Lys Thr Lys 485 490 495 Ala Ile Arg Val Ala Lys Asp Ser Ala Glu Cys Leu Gly Lys Val Ser 500 505 510 Asp Ile Thr Val Thr Lys Asn Val Ile Asn Asn Asn Ser Lys Glu Thr 515 520 525 Glu Gln Pro Asn Ile Glu Leu Leu Arg Val Ser Asp Asn Leu Val Val 530 535 540 Ser Glu Asn Ser 545 83 324 DNA Streptococcus pneumoniae 83 gtgatgaaag aaactcagct attaaaaggt gttcttgaag gttgtgtctt ggatatgatt 60 ggtcaaaaag agcggtatgg ttatgagttg gttcagactt tgcgagaggc tggatttgat 120 actatcgttc caggaactat ttatcctttg ttgcaaaagt tagaaaaaaa tcaatggata 180 agaggcgaca tgcgcccgtc gccagatggt ccagatcgga agtatttttc attaatgaaa 240 gaaggagaag agcgtgtctc agtcttttgg caacaatggg acgatttgag tcaaaaagta 300 gaagggatta agaatggggg ttaa 324 84 107 PRT Streptococcus pneumoniae 84 Met Met Lys Glu Thr Gln Leu Leu Lys Gly Val Leu Glu Gly Cys Val 1 5 10 15 Leu Asp Met Ile Gly Gln Lys Glu Arg Tyr Gly Tyr Glu Leu Val Gln 20 25 30 Thr Leu Arg Glu Ala Gly Phe Asp Thr Ile Val Pro Gly Thr Ile Tyr 35 40 45 Pro Leu Leu Gln Lys Leu Glu Lys Asn Gln Trp Ile Arg Gly Asp Met 50 55 60 Arg Pro Ser Pro Asp Gly Pro Asp Arg Lys Tyr Phe Ser Leu Met Lys 65 70 75 80 Glu Gly Glu Glu Arg Val Ser Val Phe Trp Gln Gln Trp Asp Asp Leu 85 90 95 Ser Gln Lys Val Glu Gly Ile Lys Asn Gly Gly 100 105 85 816 DNA Streptococcus pneumoniae 85 atgaagaaaa tgaagtatta cgaagaaaca agcgctttgc tacatgagtt ttctgaggag 60 aatcaaaagt attttgagga gttgtgggaa agttttaatc ttgctggatt tctctatgat 120 gaagactatc tcagagagca gatctatttg atgatgctag atttctcaga agcagaacga 180 gatggcatga gtgcagagga ttatctaggt aagaatccta aaaaaataat gaaagagatt 240 ctcaagggag cacctcgcag ttctatcaaa gagtcccttt tgacgccaat tcttgtcctg 300 gcggtattac gttattatca actactaagt gatttttcta aaggtcctct cttaacagtc 360 aatttgctca catttttagg gcaacttctt atttttctga ttggatttgg acttgtggcc 420 acaattttac gaagaagttt agtccaagat tctcctaaaa tgaaaattgg cacttacatt 480 gttgttggga ctatagttct tctagttgtt ttaggatatg taggaatggc aagcttcata 540 caagaaggag ccttttatat tccggctccc tgggatagtt tgtctgtctt tacgatttcg 600 ctagttatcg gtatttggaa ttggaaagaa gcggtctttc gtccatttgt cagtatgatt 660 attgcccatc ttgtggtggg ttctctgctc cgttattatg agtggatggg aatttcaaat 720 gttttcctta caaaagttat tcctttagct gtcctcttta ttggaatctt tgtcttgttc 780 cgtgggttta agaagataaa atggagtgaa gtatag 816 86 271 PRT Streptococcus pneumoniae 86 Met Lys Lys Met Lys Tyr Tyr Glu Glu Thr Ser Ala Leu Leu His Glu 1 5 10 15 Phe Ser Glu Glu Asn Gln Lys Tyr Phe Glu Glu Leu Trp Glu Ser Phe 20 25 30 Asn Leu Ala Gly Phe Leu Tyr Asp Glu Asp Tyr Leu Arg Glu Gln Ile 35 40 45 Tyr Leu Met Met Leu Asp Phe Ser Glu Ala Glu Arg Asp Gly Met Ser 50 55 60 Ala Glu Asp Tyr Leu Gly Lys Asn Pro Lys Lys Ile Met Lys Glu Ile 65 70 75 80 Leu Lys Gly Ala Pro Arg Ser Ser Ile Lys Glu Ser Leu Leu Thr Pro 85 90 95 Ile Leu Val Leu Ala Val Leu Arg Tyr Tyr Gln Leu Leu Ser Asp Phe 100 105 110 Ser Lys Gly Pro Leu Leu Thr Val Asn Leu Leu Thr Phe Leu Gly Gln 115 120 125 Leu Leu Ile Phe Leu Ile Gly Phe Gly Leu Val Ala Thr Ile Leu Arg 130 135 140 Arg Ser Leu Val Gln Asp Ser Pro Lys Met Lys Ile Gly Thr Tyr Ile 145 150 155 160 Val Val Gly Thr Ile Val Leu Leu Val Val Leu Gly Tyr Val Gly Met 165 170 175 Ala Ser Phe Ile Gln Glu Gly Ala Phe Tyr Ile Pro Ala Pro Trp Asp 180 185 190 Ser Leu Ser Val Phe Thr Ile Ser Leu Val Ile Gly Ile Trp Asn Trp 195 200 205 Lys Glu Ala Val Phe Arg Pro Phe Val Ser Met Ile Ile Ala His Leu 210 215 220 Val Val Gly Ser Leu Leu Arg Tyr Tyr Glu Trp Met Gly Ile Ser Asn 225 230 235 240 Val Phe Leu Thr Lys Val Ile Pro Leu Ala Val Leu Phe Ile Gly Ile 245 250 255 Phe Val Leu Phe Arg Gly Phe Lys Lys Ile Lys Trp Ser Glu Val 260 265 270 87 348 DNA Streptococcus pneumoniae 87 ctgttttttt atttatactc aatgaaaatc aaagagcaaa ctaggaagct agccgcaggt 60 tgctcaaaac actgttttga ggttgtagac gaaactgacg aagtcagctc aaaacatgtt 120 tttgaggttg tagatgaaac tgacgaagtc agctcaaaac actgttttga ggttgtagat 180 gaaactgacg aagtcagctc aaaacactgt tttgaggttg tagatgaaac tgacgaagtc 240 agctcaaaac atgtttttga ggttgtagat gaaactgacg aagtcagtaa ccatacatac 300 ggtagggcga cgctgacgtg gtttgaagag attttcgaag agtattaa 348 88 115 PRT Streptococcus pneumoniae 88 Met Phe Phe Tyr Leu Tyr Ser Met Lys Ile Lys Glu Gln Thr Arg Lys 1 5 10 15 Leu Ala Ala Gly Cys Ser Lys His Cys Phe Glu Val Val Asp Glu Thr 20 25 30 Asp Glu Val Ser Ser Lys His Val Phe Glu Val Val Asp Glu Thr Asp 35 40 45 Glu Val Ser Ser Lys His Cys Phe Glu Val Val Asp Glu Thr Asp Glu 50 55 60 Val Ser Ser Lys His Cys Phe Glu Val Val Asp Glu Thr Asp Glu Val 65 70 75 80 Ser Ser Lys His Val Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser 85 90 95 Asn His Thr Tyr Gly Arg Ala Thr Leu Thr Trp Phe Glu Glu Ile Phe 100 105 110 Glu Glu Tyr 115 89 1260 DNA Streptococcus pneumoniae 89 atgcagaatc tgaaatttgc cttttcatct atcatggctc acaagatgcg ttctttgctt 60 actatgattg ggattattat cggtgtttca tcagttgttg tgattatggc tttgggtgat 120 tccctatctc gtcaagtcaa taaagatatg actaaatctc agaaaaatat tagcgtcttt 180 ttctctccta aaaaaagtaa agacgggtct tttactcaga aacaatcagc ttttacggtt 240 tctggaaagg aagaggaagt tcctgttgaa ccgccaaaac cgcaagaatc ctgggtccaa 300 gaggcagcta aactgaaggg agtggatagt tactatgtaa ccaattcaac gaatgccatc 360 ttgacctatc aagataaaaa ggttgagaat gctaatttga caggtggaaa cagaacttac 420 atggacgctg ttaagaatga aattattgca ggtcgtagtc tgagagagca agatttcaaa 480 gagtttgcaa gtgtcatttt gctagatgag gaattgtcca ttagtttatt tgaatctcct 540 caagaggcta ttaacaaggt tgtagaagtc aatggattta gttaccgggt cattggggtt 600 tatactagtc cggaggctaa aagatcaaaa atatatgggt ttggtggctt gcctattact 660 accaatatct cccttgctgc gaattttaat gtagatgaaa tagctaatat tgtctttcga 720 gtgaatgata ccagtttaac cccaactctg ggtccagaac tggcacgaaa aatgacagag 780 cttgcaggct tacaacaggg agaataccag gtggcagatg agtccgttgt atttgcagaa 840 attcaacaat cgtttagttt tatgacgacg attattagtt ccatcgcagg gatttctctc 900 tttgttggag gaactggtgt catgaacatc atgctggttt cggtgacaga gcgcactcgt 960 gagattggtc ttcgtaaggc tttgggtgca acacgtgcca atattttaat tcagtttttg 1020 attgaatcca tgattttgac cttgttaggt ggcttaattg gcttgacaat tgcaagtggt 1080 ttaactgcct tagcaggttt gttactgcaa ggtttaatag aaggtataga agttggagta 1140 tcaatcccag tcgccctatt tagtcttgca gtttcggcta gtgttggtat gatttttgga 1200 gtcttgccag ccaacaaggc atcgaaactt gatccaattg aagcccttcg ttatgaatga 1260 90 419 PRT Streptococcus pneumoniae 90 Met Gln Asn Leu Lys Phe Ala Phe Ser Ser Ile Met Ala His Lys Met 1 5 10 15 Arg Ser Leu Leu Thr Met Ile Gly Ile Ile Ile Gly Val Ser Ser Val 20 25 30 Val Val Ile Met Ala Leu Gly Asp Ser Leu Ser Arg Gln Val Asn Lys 35 40 45 Asp Met Thr Lys Ser Gln Lys Asn Ile Ser Val Phe Phe Ser Pro Lys 50 55 60 Lys Ser Lys Asp Gly Ser Phe Thr Gln Lys Gln Ser Ala Phe Thr Val 65 70 75 80 Ser Gly Lys Glu Glu Glu Val Pro Val Glu Pro Pro Lys Pro Gln Glu 85 90 95 Ser Trp Val Gln Glu Ala Ala Lys Leu Lys Gly Val Asp Ser Tyr Tyr 100 105 110 Val Thr Asn Ser Thr Asn Ala Ile Leu Thr Tyr Gln Asp Lys Lys Val 115 120 125 Glu Asn Ala Asn Leu Thr Gly Gly Asn Arg Thr Tyr Met Asp Ala Val 130 135 140 Lys Asn Glu Ile Ile Ala Gly Arg Ser Leu Arg Glu Gln Asp Phe Lys 145 150 155 160 Glu Phe Ala Ser Val Ile Leu Leu Asp Glu Glu Leu Ser Ile Ser Leu 165 170 175 Phe Glu Ser Pro Gln Glu Ala Ile Asn Lys Val Val Glu Val Asn Gly 180 185 190 Phe Ser Tyr Arg Val Ile Gly Val Tyr Thr Ser Pro Glu Ala Lys Arg 195 200 205 Ser Lys Ile Tyr Gly Phe Gly Gly Leu Pro Ile Thr Thr Asn Ile Ser 210 215 220 Leu Ala Ala Asn Phe Asn Val Asp Glu Ile Ala Asn Ile Val Phe Arg 225 230 235 240 Val Asn Asp Thr Ser Leu Thr Pro Thr Leu Gly Pro Glu Leu Ala Arg 245 250 255 Lys Met Thr Glu Leu Ala Gly Leu Gln Gln Gly Glu Tyr Gln Val Ala 260 265 270 Asp Glu Ser Val Val Phe Ala Glu Ile Gln Gln Ser Phe Ser Phe Met 275 280 285 Thr Thr Ile Ile Ser Ser Ile Ala Gly Ile Ser Leu Phe Val Gly Gly 290 295 300 Thr Gly Val Met Asn Ile Met Leu Val Ser Val Thr Glu Arg Thr Arg 305 310 315 320 Glu Ile Gly Leu Arg Lys Ala Leu Gly Ala Thr Arg Ala Asn Ile Leu 325 330 335 Ile Gln Phe Leu Ile Glu Ser Met Ile Leu Thr Leu Leu Gly Gly Leu 340 345 350 Ile Gly Leu Thr Ile Ala Ser Gly Leu Thr Ala Leu Ala Gly Leu Leu 355 360 365 Leu Gln Gly Leu Ile Glu Gly Ile Glu Val Gly Val Ser Ile Pro Val 370 375 380 Ala Leu Phe Ser Leu Ala Val Ser Ala Ser Val Gly Met Ile Phe Gly 385 390 395 400 Val Leu Pro Ala Asn Lys Ala Ser Lys Leu Asp Pro Ile Glu Ala Leu 405 410 415 Arg Tyr Glu 91 705 DNA Streptococcus pneumoniae 91 ctgatgaagc aactaattag tctaaaaaat atcttcagaa gttaccgtaa tggtgaccaa 60 gaactgcagg ttctcaaaaa tatcaatcta gaagtgaatg agggtgaatt tgtagccatc 120 atgggaccat ctgggtctgg taagtccact ctgatgaata cgattggcat gttggataca 180 ccaaccagtg gagaatatta tcttgaaggt caagaagtgg ctgggcttgg tgaaaaacaa 240 ctagctaagg tccgtaacca acaaatcggt tttgtctttc agcagttctt tcttctatcg 300 aagctcaatg ctctgcaaaa tgtagaattg cccttgattt acgcaggagt ttcgtcttca 360 aaacgtcgca agttggctga ggaatattta gacaaggttg aattgacaga acgtagtcac 420 catttacctt cagaattatc tggtggtcaa aagcaacgtg tagccattgc gcgtgccttg 480 gtaaacaatc cttctattat cctagcggat gaaccgacag gagccttgga taccaaaaca 540 ggtaaccaaa ttatgcaatt attggttgat ttgaataaag aaggaaaaac cattatcatg 600 gtaacgcatg agcctgagat tgctgcctat gccaaacgtc agattgtcat tcgggatggg 660 gtcatttcgt ctgacagtgc tcagttagga aaggaggaaa actaa 705 92 234 PRT Streptococcus pneumoniae 92 Met Met Lys Gln Leu Ile Ser Leu Lys Asn Ile Phe Arg Ser Tyr Arg 1 5 10 15 Asn Gly Asp Gln Glu Leu Gln Val Leu Lys Asn Ile Asn Leu Glu Val 20 25 30 Asn Glu Gly Glu Phe Val Ala Ile Met Gly Pro Ser Gly Ser Gly Lys 35 40 45 Ser Thr Leu Met Asn Thr Ile Gly Met Leu Asp Thr Pro Thr Ser Gly 50 55 60 Glu Tyr Tyr Leu Glu Gly Gln Glu Val Ala Gly Leu Gly Glu Lys Gln 65 70 75 80 Leu Ala Lys Val Arg Asn Gln Gln Ile Gly Phe Val Phe Gln Gln Phe 85 90 95 Phe Leu Leu Ser Lys Leu Asn Ala Leu Gln Asn Val Glu Leu Pro Leu 100 105 110 Ile Tyr Ala Gly Val Ser Ser Ser Lys Arg Arg Lys Leu Ala Glu Glu 115 120 125 Tyr Leu Asp Lys Val Glu Leu Thr Glu Arg Ser His His Leu Pro Ser 130 135 140 Glu Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu 145 150 155 160 Val Asn Asn Pro Ser Ile Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu 165 170 175 Asp Thr Lys Thr Gly Asn Gln Ile Met Gln Leu Leu Val Asp Leu Asn 180 185 190 Lys Glu Gly Lys Thr Ile Ile Met Val Thr His Glu Pro Glu Ile Ala 195 200 205 Ala Tyr Ala Lys Arg Gln Ile Val Ile Arg Asp Gly Val Ile Ser Ser 210 215 220 Asp Ser Ala Gln Leu Gly Lys Glu Glu Asn 225 230 93 1200 DNA Streptococcus pneumoniae 93 atgaagaaaa agaatggtaa agctaaaaag tggcaactgt atgcagcaat cggtgctgcg 60 agtgtagttg tattgggtgc tggggggatt ttactcttta gacaaccttc tcagactgct 120 ctaaaagatg agcctactca tcttgttgtt gccaaggaag gaagcgtggc ctcctctgtt 180 ttattgtcag ggacagtaac agcaaaaaat gaacaatatg tttattttga tgctagtaag 240 ggtgatttag atgaaatcct tgtttctgtg ggcgataagg tcagcgaagg gcaggcttta 300 gtcaagtaca gtagttcaga agcgcaggcg gcctatgatt cagctagtcg agcagtagct 360 agggcagatc gtcatatcaa tgaactcaat caagcacgaa atgaagccgc ttcagctccg 420 gctccacagt taccagcgcc agtaggagga gaagatgcaa cggtgcaaag cccaactcca 480 gtggctggaa attctgttgc ttctattgac gctcaattgg gtgatgcccg tgatgcgcgt 540 gcagatgctg cggcgcaatt aagcaaggct caaagtcaat tggatgcaac aactgttctc 600 agtaccctag agggaactgt ggtcgaagtc aatagcaatg tttctaaatc tccaacaggg 660 gcgagtcaag ttatggttca tattgtcagc aatgaaaatt tacaagtcaa gggagaattg 720 tctgagtaca atctagccaa cctttctgta ggtcaagaag taagctttac ttctaaagtg 780 tatcctgata aaaaatggac tgggaaatta agctatattt ctgactatcc taaaaacaat 840 ggtgaagcag ctagtccagc agccgggaat aatacaggtt ctaaataccc ttatactatt 900 gatgtgacag gcgaggttgg tgatttgaaa caaggttttt ctgtcaacat tgaggttaaa 960 agcaaaacta aggctattct tgttcctgtt agcagtctag taatggatga tagtaaaaat 1020 tatgtctgga ttgtggatga acaacaaaag gctaaaaaag ttgaggtttc attgggaaat 1080 gctgacgcag aaaatcaaga aatcacttct ggtttaacga acggtgctaa ggtcatcagt 1140 aatccaacat cttccttgga agaaggaaaa gaggtgaagg ctgatgaagc aactaattag 1200 94 399 PRT Streptococcus pneumoniae 94 Met Lys Lys Lys Asn Gly Lys Ala Lys Lys Trp Gln Leu Tyr Ala Ala 1 5 10 15 Ile Gly Ala Ala Ser Val Val Val Leu Gly Ala Gly Gly Ile Leu Leu 20 25 30 Phe Arg Gln Pro Ser Gln Thr Ala Leu Lys Asp Glu Pro Thr His Leu 35 40 45 Val Val Ala Lys Glu Gly Ser Val Ala Ser Ser Val Leu Leu Ser Gly 50 55 60 Thr Val Thr Ala Lys Asn Glu Gln Tyr Val Tyr Phe Asp Ala Ser Lys 65 70 75 80 Gly Asp Leu Asp Glu Ile Leu Val Ser Val Gly Asp Lys Val Ser Glu 85 90 95 Gly Gln Ala Leu Val Lys Tyr Ser Ser Ser Glu Ala Gln Ala Ala Tyr 100 105 110 Asp Ser Ala Ser Arg Ala Val Ala Arg Ala Asp Arg His Ile Asn Glu 115 120 125 Leu Asn Gln Ala Arg Asn Glu Ala Ala Ser Ala Pro Ala Pro Gln Leu 130 135 140 Pro Ala Pro Val Gly Gly Glu Asp Ala Thr Val Gln Ser Pro Thr Pro 145 150 155 160 Val Ala Gly Asn Ser Val Ala Ser Ile Asp Ala Gln Leu Gly Asp Ala 165 170 175 Arg Asp Ala Arg Ala Asp Ala Ala Ala Gln Leu Ser Lys Ala Gln Ser 180 185 190 Gln Leu Asp Ala Thr Thr Val Leu Ser Thr Leu Glu Gly Thr Val Val 195 200 205 Glu Val Asn Ser Asn Val Ser Lys Ser Pro Thr Gly Ala Ser Gln Val 210 215 220 Met Val His Ile Val Ser Asn Glu Asn Leu Gln Val Lys Gly Glu Leu 225 230 235 240 Ser Glu Tyr Asn Leu Ala Asn Leu Ser Val Gly Gln Glu Val Ser Phe 245 250 255 Thr Ser Lys Val Tyr Pro Asp Lys Lys Trp Thr Gly Lys Leu Ser Tyr 260 265 270 Ile Ser Asp Tyr Pro Lys Asn Asn Gly Glu Ala Ala Ser Pro Ala Ala 275 280 285 Gly Asn Asn Thr Gly Ser Lys Tyr Pro Tyr Thr Ile Asp Val Thr Gly 290 295 300 Glu Val Gly Asp Leu Lys Gln Gly Phe Ser Val Asn Ile Glu Val Lys 305 310 315 320 Ser Lys Thr Lys Ala Ile Leu Val Pro Val Ser Ser Leu Val Met Asp 325 330 335 Asp Ser Lys Asn Tyr Val Trp Ile Val Asp Glu Gln Gln Lys Ala Lys 340 345 350 Lys Val Glu Val Ser Leu Gly Asn Ala Asp Ala Glu Asn Gln Glu Ile 355 360 365 Thr Ser Gly Leu Thr Asn Gly Ala Lys Val Ile Ser Asn Pro Thr Ser 370 375 380 Ser Leu Glu Glu Gly Lys Glu Val Lys Ala Asp Glu Ala Thr Asn 385 390 395 95 759 DNA Streptococcus pneumoniae 95 atgtcacgta aaccatttat cgctggtaac tggaaaatga acaaaaatcc agaagaagct 60 aaagcattcg ttgaagcagt tgcatcaaaa cttccttcat cagatcttgt tgaagcaggt 120 atcgctgctc cagctcttga tttgacaact gttcttgctg ttgcaaaagg ctcaaacctt 180 aaagttgctg ctcaaaactg ctactttgaa aatgcaggtg ctttcactgg tgaaactagc 240 ccacaagttt tgaaagaaat cggtactgac tacgttgtta tcggtcactc agaacgccgt 300 gactacttcc atgaaactga tgaagatatc aacaaaaaag caaaagcaat ctttgcgaac 360 ggtatgcttc caatcatctg ttgtggtgaa tcacttgaaa cttacgaagc tggtaaagct 420 gctgaattcg taggtgctca agtatctgct gcattggctg gattgactgc tgaacaagtt 480 gctgcctcag ttatcgctta tgagccaatc tgggctatcg gtactggtaa atcagcttca 540 caagacgatg cacaaaaaat gtgtaaagtt gttcgtgacg ttgtagctgc tgactttggt 600 caagaagtcg cagacaaagt tcgtgttcaa tacggtggtt ctgttaaacc tgaaaatgtt 660 gcttcataca tggcttgccc agacgttgac ggtgcccttg taggtggtgc gtcacttgaa 720 gctgaaagct tcttggcttt gcttgacttt gtaaaataa 759 96 252 PRT Streptococcus pneumoniae 96 Met Ser Arg Lys Pro Phe Ile Ala Gly Asn Trp Lys Met Asn Lys Asn 1 5 10 15 Pro Glu Glu Ala Lys Ala Phe Val Glu Ala Val Ala Ser Lys Leu Pro 20 25 30 Ser Ser Asp Leu Val Glu Ala Gly Ile Ala Ala Pro Ala Leu Asp Leu 35 40 45 Thr Thr Val Leu Ala Val Ala Lys Gly Ser Asn Leu Lys Val Ala Ala 50 55 60 Gln Asn Cys Tyr Phe Glu Asn Ala Gly Ala Phe Thr Gly Glu Thr Ser 65 70 75 80 Pro Gln Val Leu Lys Glu Ile Gly Thr Asp Tyr Val Val Ile Gly His 85 90 95 Ser Glu Arg Arg Asp Tyr Phe His Glu Thr Asp Glu Asp Ile Asn Lys 100 105 110 Lys Ala Lys Ala Ile Phe Ala Asn Gly Met Leu Pro Ile Ile Cys Cys 115 120 125 Gly Glu Ser Leu Glu Thr Tyr Glu Ala Gly Lys Ala Ala Glu Phe Val 130 135 140 Gly Ala Gln Val Ser Ala Ala Leu Ala Gly Leu Thr Ala Glu Gln Val 145 150 155 160 Ala Ala Ser Val Ile Ala Tyr Glu Pro Ile Trp Ala Ile Gly Thr Gly 165 170 175 Lys Ser Ala Ser Gln Asp Asp Ala Gln Lys Met Cys Lys Val Val Arg 180 185 190 Asp Val Val Ala Ala Asp Phe Gly Gln Glu Val Ala Asp Lys Val Arg 195 200 205 Val Gln Tyr Gly Gly Ser Val Lys Pro Glu Asn Val Ala Ser Tyr Met 210 215 220 Ala Cys Pro Asp Val Asp Gly Ala Leu Val Gly Gly Ala Ser Leu Glu 225 230 235 240 Ala Glu Ser Phe Leu Ala Leu Leu Asp Phe Val Lys 245 250 97 1473 DNA Streptococcus pneumoniae 97 ttgaaaacaa aaattggatt agcaagtatc tgtttactag gcttggcaac tagtcatgtc 60 gctgcaaatg aaactgaagt agcaaaaact tcgcaggata caacgacagc ttcaagtagt 120 tcagagcaaa atcagtcttc taataaaacg caaacgagcg cagaagtaca gactaatgct 180 gctgcccact gggatgggga ttattatgta aaggatgatg gttctaaagc tcaaagtgaa 240 tggatttttg acaactacta taaggcttgg ttttatatta attcagatgg tcgttactcg 300 cagaatgaat ggcatggaaa ttactacctg aaatcaggtg gatatatggc ccaaaacgag 360 tggatctatg acagtaatta caagagttgg ttttatctca agtcagatgg ggcttatgct 420 catcaagaat ggcaattgat tggaaataag tggtactact tcaagaagtg gggttacatg 480 gctaaaagcc aatggcaagg aagttatttc ttgaatggtc aaggagctat gatgcaaaat 540 gaatggctct atgatccagc ctattctgct tatttttatc taaaatccga tggaacttat 600 gctaaccaag agtggcaaaa agtgggcggc aaatggtact atttcaagaa gtggggctat 660 atggctcgga atgagtggca aggcaactac tatttgactg gaagtggtgc catggcgact 720 gacgaagtga ttatggatgg tactcgctat atctttgcgg cctctggtga gctcaaagaa 780 aaaaaagatt tgaatgtcgg ctgggttcac agagatggta agcgctattt ctttaataat 840 agagaagaac aagtgggaac cgaacatgct aagaaagtca ttgatattag tgagcacaat 900 ggtcgtatca atgattggaa aaaggttatt gatgagaacg aagtggatgg tgtcattgtt 960 cgtctaggtt atagcggtaa agaagacaag gaattggcgc ataacattaa ggagttaaac 1020 cgtctgggaa ttccttatgg tgtctatctc tatacctatg ctgaaaatga gaccgatgct 1080 gagagtgacg ctaaacagac cattgaactt ataaagaaat acaatatgaa cctgtcttac 1140 cctatctatt atgatgttga gaattgggaa tatgtaaata agagcaagag agctccaagt 1200 gatacaggca cttgggttaa aatcatcaac aagtacatgg acacgatgaa gcaggcgggt 1260 tatcaaaatg tgtatgtcta tagctatcgt agtttattac agacgcgttt aaaacaccca 1320 gatattttaa aacatgtaaa ctgggtagcg gcctatacga atgctttaga atgggaaaac 1380 cctcattatt caggaaaaaa aggttggcaa tatacctctt ctgaatacat gaaaggaatc 1440 caagggcgcg tagatgtcag cgtttggtat taa 1473 98 490 PRT Streptococcus pneumoniae 98 Met Lys Thr Lys Ile Gly Leu Ala Ser Ile Cys Leu Leu Gly Leu Ala 1 5 10 15 Thr Ser His Val Ala Ala Asn Glu Thr Glu Val Ala Lys Thr Ser Gln 20 25 30 Asp Thr Thr Thr Ala Ser Ser Ser Ser Glu Gln Asn Gln Ser Ser Asn 35 40 45 Lys Thr Gln Thr Ser Ala Glu Val Gln Thr Asn Ala Ala Ala His Trp 50 55 60 Asp Gly Asp Tyr Tyr Val Lys Asp Asp Gly Ser Lys Ala Gln Ser Glu 65 70 75 80 Trp Ile Phe Asp Asn Tyr Tyr Lys Ala Trp Phe Tyr Ile Asn Ser Asp 85 90 95 Gly Arg Tyr Ser Gln Asn Glu Trp His Gly Asn Tyr Tyr Leu Lys Ser 100 105 110 Gly Gly Tyr Met Ala Gln Asn Glu Trp Ile Tyr Asp Ser Asn Tyr Lys 115 120 125 Ser Trp Phe Tyr Leu Lys Ser Asp Gly Ala Tyr Ala His Gln Glu Trp 130 135 140 Gln Leu Ile Gly Asn Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met 145 150 155 160 Ala Lys Ser Gln Trp Gln Gly Ser Tyr Phe Leu Asn Gly Gln Gly Ala 165 170 175 Met Met Gln Asn Glu Trp Leu Tyr Asp Pro Ala Tyr Ser Ala Tyr Phe 180 185 190 Tyr Leu Lys Ser Asp Gly Thr Tyr Ala Asn Gln Glu Trp Gln Lys Val 195 200 205 Gly Gly Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met Ala Arg Asn 210 215 220 Glu Trp Gln Gly Asn Tyr Tyr Leu Thr Gly Ser Gly Ala Met Ala Thr 225 230 235 240 Asp Glu Val Ile Met Asp Gly Thr Arg Tyr Ile Phe Ala Ala Ser Gly 245 250 255 Glu Leu Lys Glu Lys Lys Asp Leu Asn Val Gly Trp Val His Arg Asp 260 265 270 Gly Lys Arg Tyr Phe Phe Asn Asn Arg Glu Glu Gln Val Gly Thr Glu 275 280 285 His Ala Lys Lys Val Ile Asp Ile Ser Glu His Asn Gly Arg Ile Asn 290 295 300 Asp Trp Lys Lys Val Ile Asp Glu Asn Glu Val Asp Gly Val Ile Val 305 310 315 320 Arg Leu Gly Tyr Ser Gly Lys Glu Asp Lys Glu Leu Ala His Asn Ile 325 330 335 Lys Glu Leu Asn Arg Leu Gly Ile Pro Tyr Gly Val Tyr Leu Tyr Thr 340 345 350 Tyr Ala Glu Asn Glu Thr Asp Ala Glu Ser Asp Ala Lys Gln Thr Ile 355 360 365 Glu Leu Ile Lys Lys Tyr Asn Met Asn Leu Ser Tyr Pro Ile Tyr Tyr 370 375 380 Asp Val Glu Asn Trp Glu Tyr Val Asn Lys Ser Lys Arg Ala Pro Ser 385 390 395 400 Asp Thr Gly Thr Trp Val Lys Ile Ile Asn Lys Tyr Met Asp Thr Met 405 410 415 Lys Gln Ala Gly Tyr Gln Asn Val Tyr Val Tyr Ser Tyr Arg Ser Leu 420 425 430 Leu Gln Thr Arg Leu Lys His Pro Asp Ile Leu Lys His Val Asn Trp 435 440 445 Val Ala Ala Tyr Thr Asn Ala Leu Glu Trp Glu Asn Pro His Tyr Ser 450 455 460 Gly Lys Lys Gly Trp Gln Tyr Thr Ser Ser Glu Tyr Met Lys Gly Ile 465 470 475 480 Gln Gly Arg Val Asp Val Ser Val Trp Tyr 485 490 99 774 DNA Streptococcus pneumoniae 99 atgaaaaaat ttgccaacct ttatctggga ctggtctttc tggtcctcta cctgcctatc 60 ttttacttga ttggctatgc ctttaatgct ggtgatgata tgaatagctt tacaggtttt 120 agctggactc actttgaaac catgtttgga gatgggagac tcatgctgat tttggctcag 180 acatttttct tggccttcct atcagccttg atagcgacca ttatcgggac ttttggtgcc 240 1 atttacatct accagtctcg taagaaatac caagaagcct ttctatcact caataatatc 300 ctcatggttg cgcctgacgt tatgattggt gctagcttct tgattctctt tacccaactc 360 aagttttcac ttggcttttt gaccgttcta tctagtcacg tggccttctc cattcctatc 420 gtggtcttga tggtcttgcc tcgactcaag gaaatgaatg gcgacatgat tcatgcggcc 480 tatgacttgg gagctagtca atttcagatg ttcaaggaaa tcatgcttcc ttacctgact 540 ccgtctatca ttactggtta tttcatggcc ttcacctatt cgttagatga ctttgccgtg 600 accttctttg taacaggaaa tggcttttca accctatcag tcgagattta ctctcgtgct 660 cgcaagggga tttccttaga aatcaatgcc ctgtctgctc tagtctttct ctttagtatt 720 atcctagttg taggttatta ctttatctct cgtgagaagg aggagcaagc atga 774 100 257 PRT Streptococcus pneumoniae 100 Met Lys Lys Phe Ala Asn Leu Tyr Leu Gly Leu Val Phe Leu Val Leu 1 5 10 15 Tyr Leu Pro Ile Phe Tyr Leu Ile Gly Tyr Ala Phe Asn Ala Gly Asp 20 25 30 Asp Met Asn Ser Phe Thr Gly Phe Ser Trp Thr His Phe Glu Thr Met 35 40 45 Phe Gly Asp Gly Arg Leu Met Leu Ile Leu Ala Gln Thr Phe Phe Leu 50 55 60 Ala Phe Leu Ser Ala Leu Ile Ala Thr Ile Ile Gly Thr Phe Gly Ala 65 70 75 80 Ile Tyr Ile Tyr Gln Ser Arg Lys Lys Tyr Gln Glu Ala Phe Leu Ser 85 90 95 Leu Asn Asn Ile Leu Met Val Ala Pro Asp Val Met Ile Gly Ala Ser 100 105 110 Phe Leu Ile Leu Phe Thr Gln Leu Lys Phe Ser Leu Gly Phe Leu Thr 115 120 125 Val Leu Ser Ser His Val Ala Phe Ser Ile Pro Ile Val Val Leu Met 130 135 140 Val Leu Pro Arg Leu Lys Glu Met Asn Gly Asp Met Ile His Ala Ala 145 150 155 160 Tyr Asp Leu Gly Ala Ser Gln Phe Gln Met Phe Lys Glu Ile Met Leu 165 170 175 Pro Tyr Leu Thr Pro Ser Ile Ile Thr Gly Tyr Phe Met Ala Phe Thr 180 185 190 Tyr Ser Leu Asp Asp Phe Ala Val Thr Phe Phe Val Thr Gly Asn Gly 195 200 205 Phe Ser Thr Leu Ser Val Glu Ile Tyr Ser Arg Ala Arg Lys Gly Ile 210 215 220 Ser Leu Glu Ile Asn Ala Leu Ser Ala Leu Val Phe Leu Phe Ser Ile 225 230 235 240 Ile Leu Val Val Gly Tyr Tyr Phe Ile Ser Arg Glu Lys Glu Glu Gln 245 250 255 Ala 101 1071 DNA Streptococcus pneumoniae 101 atgaaaaaaa tctattcatt tttagcagga attgcagcga ttatccttgt cttgtgggga 60 attgcgactc atttagatag taaaatcaat agtcgagata gtcaaaaatt ggttatctat 120 aactggggag actatatcga tcctgaactc ttgactcagt ttacagaaga aacaggaatt 180 caagttcagt acgagacttt tgactccaac gaagccatgt acactaagat aaagcagggt 240 ggaacgacct acgatattgc cattccaagt gaatacatga ttaacaagat gaaggacgaa 300 gacctcttgg ttccgcttga ttattcaaaa attgaaggaa tcgaaaatat cggaccagag 360 tttctcaacc agtcctttga cccaggtaat aaattctcca tcccttactt ctggggaacc 420 ttaggaattg tctacaacga aaccatggta gatgaagcgc ctgagcattg ggatgacctt 480 tggaagccgg agtataagaa ttctatcatg ctctttgatg gggcgcgtga ggtgctggga 540 ctaggactca attccctcgg ctacagcctc aactccaagg atctgcagca gttggaagag 600 acagtggata agctctacaa actgactcca aatatcaagg ctatcgttgc ggacgagatg 660 aagggctata tgattcagaa taatgttgca atcggcgtga ccttctctgg tgaagccagc 720 caaatgttag aaaaaaatga aaatctacgt tatgtggtac cgacagaggc cagcaatctt 780 tggtttgaca atatggtcat tcccaaaaca gttaaaaacc aaaactcagc ctatgccttt 840 atcaacttta tgttgaaacc tgaaaatgct ctccaaaatg cggagtatgt cggctattca 900 acaccaaacc taccagcgaa ggaattgctc ccagaggaaa caaaggaaga taaggccttc 960 tatcccgatg ttgaaaccat gaaacaccta gaagtttatg agaaatttga ccataaatgg 1020 acagggaaat atagcgacct cttcctacag tttaaaatgt atcggaagta g 1071 102 356 PRT Streptococcus pneumoniae 102 Met Lys Lys Ile Tyr Ser Phe Leu Ala Gly Ile Ala Ala Ile Ile Leu 1 5 10 15 Val Leu Trp Gly Ile Ala Thr His Leu Asp Ser Lys Ile Asn Ser Arg 20 25 30 Asp Ser Gln Lys Leu Val Ile Tyr Asn Trp Gly Asp Tyr Ile Asp Pro 35 40 45 Glu Leu Leu Thr Gln Phe Thr Glu Glu Thr Gly Ile Gln Val Gln Tyr 50 55 60 Glu Thr Phe Asp Ser Asn Glu Ala Met Tyr Thr Lys Ile Lys Gln Gly 65 70 75 80 Gly Thr Thr Tyr Asp Ile Ala Ile Pro Ser Glu Tyr Met Ile Asn Lys 85 90 95 Met Lys Asp Glu Asp Leu Leu Val Pro Leu Asp Tyr Ser Lys Ile Glu 100 105 110 Gly Ile Glu Asn Ile Gly Pro Glu Phe Leu Asn Gln Ser Phe Asp Pro 115 120 125 Gly Asn Lys Phe Ser Ile Pro Tyr Phe Trp Gly Thr Leu Gly Ile Val 130 135 140 Tyr Asn Glu Thr Met Val Asp Glu Ala Pro Glu His Trp Asp Asp Leu 145 150 155 160 Trp Lys Pro Glu Tyr Lys Asn Ser Ile Met Leu Phe Asp Gly Ala Arg 165 170 175 Glu Val Leu Gly Leu Gly Leu Asn Ser Leu Gly Tyr Ser Leu Asn Ser 180 185 190 Lys Asp Leu Gln Gln Leu Glu Glu Thr Val Asp Lys Leu Tyr Lys Leu 195 200 205 Thr Pro Asn Ile Lys Ala Ile Val Ala Asp Glu Met Lys Gly Tyr Met 210 215 220 Ile Gln Asn Asn Val Ala Ile Gly Val Thr Phe Ser Gly Glu Ala Ser 225 230 235 240 Gln Met Leu Glu Lys Asn Glu Asn Leu Arg Tyr Val Val Pro Thr Glu 245 250 255 Ala Ser Asn Leu Trp Phe Asp Asn Met Val Ile Pro Lys Thr Val Lys 260 265 270 Asn Gln Asn Ser Ala Tyr Ala Phe Ile Asn Phe Met Leu Lys Pro Glu 275 280 285 Asn Ala Leu Gln Asn Ala Glu Tyr Val Gly Tyr Ser Thr Pro Asn Leu 290 295 300 Pro Ala Lys Glu Leu Leu Pro Glu Glu Thr Lys Glu Asp Lys Ala Phe 305 310 315 320 Tyr Pro Asp Val Glu Thr Met Lys His Leu Glu Val Tyr Glu Lys Phe 325 330 335 Asp His Lys Trp Thr Gly Lys Tyr Ser Asp Leu Phe Leu Gln Phe Lys 340 345 350 Met Tyr Arg Lys 355 103 1851 DNA Streptococcus pneumoniae 103 atgaataaaa aactaacaga ttatgtgatt gatctggtgg aaattttaaa taaacaacaa 60 aagcaggttt tctggggaat atttgatatt ttcagtatgg tggtttccat cattgtatct 120 tatattttat tttatgggct gattaatcca gcacctgttg actacattat ctatacgagt 180 ttggccttcc tgttctatca attgatgatt ggtttttggg ggttgaacgc gagcattagt 240 cgttacagca agattacgga tttcatgaaa atcttttttg gtgtgactgc tagcagtgtc 300 ttgtcatata gtatctgtta tgccttcttg ccactcttct ccatccgttt catcattctc 360 tttatcttgt tgagtacctt cttgatttta ttgccacgga ttacttggca gttaatctac 420 tccagacgca aaaaaggtag tggtgatgga gaacaccgtc ggaccttctt gattggtgcc 480 ggtgatggtg gggctctttt tatggatagt taccaacatc caaccagtga attagaactg 540 gtcggtattt tggataagga ttctaagaaa aagggtcaaa aacttggtgg tattcctgtt 600 ttgggctctt atgacaatct gcctgaatta gccaaacgcc atcaaatcga gcgtgtcatc 660 gttgcgattc cgtcgctgga tccgtcagaa tatgagcgta tcttgcagat gtgtaataag 720 ctgggtgtca aatgttacaa gatgcctaag gttgaaactg ttgttcaggg ccttcaccaa 780 gcaggtactg gcttccaaaa aattgatatt acggaccttt tgggtcgtca ggaaatccgt 840 cttgacgaat cgcgtctggg tgcagaactg acaggtaaga ccatcttagt cacaggagct 900 ggaggttcaa tcggttctga aatctgtcgt caagttagtc gcttcaatcc tgaacgcatt 960 gtcttgctcg gtcatgggga aaactcaatc taccttgttt atcatgaatt gattcgtaag 1020 ttccaaggga ttgattatgt acctgtgatt gcggacattc aagactatga tcgtttgttg 1080 caagtctttg agcagtacaa acctgctatt gtttatcatg cggcagccca caagcatgtt 1140 cctatgatgg agcgcaatcc aaaagaagcc ttcaaaaaca atatccgtgg aacttacaat 1200 gttgctaagg ctgttgatga agctaaagtg tctaagatgg ttatgatttc gacagataag 1260 gcagtcaatc caccaaatgt tatgggagca accaagcgcg tggcggagtt gattgtcact 1320 ggctttaacc aacgtagcca atcaacctac tgtgcagttc gttttgggaa tgttcttggt 1380 agccgtggta gtgtcattcc agtctttgaa cgtcagattg ctgaaggtgg gcctgtaacg 1440 gtgacagact tccgtatgac ccgttacttt atgaccattc cagaagctag ccgtctggtt 1500 atccatgctg gtgcttatgc caaagatggg gaagtcttta tccttgatat gggcaaacca 1560 gtcaagattt atgacttggc caagaagatg gtgcttctaa gtggccacac tgaaagtgaa 1620 attccaatcg ttgaagttgg aatccgccca ggtgaaaaac tctacgaaga actcttggta 1680 tcaaccgaac tcgttgataa tcaagttatg gataagattt tcgttggtaa ggttaatgtc 1740 atgcctttag aatccatcaa tcaaaagatt ggagagttcc gcactctcag tggagatgag 1800 ttgaagcaag ctattatcgc ctttgctaat caaacaaccc acattgaata a 1851 104 616 PRT Streptococcus pneumoniae 104 Met Asn Lys Lys Leu Thr Asp Tyr Val Ile Asp Leu Val Glu Ile Leu 1 5 10 15 Asn Lys Gln Gln Lys Gln Val Phe Trp Gly Ile Phe Asp Ile Phe Ser 20 25 30 Met Val Val Ser Ile Ile Val Ser Tyr Ile Leu Phe Tyr Gly Leu Ile 35 40 45 Asn Pro Ala Pro Val Asp Tyr Ile Ile Tyr Thr Ser Leu Ala Phe Leu 50 55 60 Phe Tyr Gln Leu Met Ile Gly Phe Trp Gly Leu Asn Ala Ser Ile Ser 65 70 75 80 Arg Tyr Ser Lys Ile Thr Asp Phe Met Lys Ile Phe Phe Gly Val Thr 85 90 95 Ala Ser Ser Val Leu Ser Tyr Ser Ile Cys Tyr Ala Phe Leu Pro Leu 100 105 110 Phe Ser Ile Arg Phe Ile Ile Leu Phe Ile Leu Leu Ser Thr Phe Leu 115 120 125 Ile Leu Leu Pro Arg Ile Thr Trp Gln Leu Ile Tyr Ser Arg Arg Lys 130 135 140 Lys Gly Ser Gly Asp Gly Glu His Arg Arg Thr Phe Leu Ile Gly Ala 145 150 155 160 Gly Asp Gly Gly Ala Leu Phe Met Asp Ser Tyr Gln His Pro Thr Ser 165 170 175 Glu Leu Glu Leu Val Gly Ile Leu Asp Lys Asp Ser Lys Lys Lys Gly 180 185 190 Gln Lys Leu Gly Gly Ile Pro Val Leu Gly Ser Tyr Asp Asn Leu Pro 195 200 205 Glu Leu Ala Lys Arg His Gln Ile Glu Arg Val Ile Val Ala Ile Pro 210 215 220 Ser Leu Asp Pro Ser Glu Tyr Glu Arg Ile Leu Gln Met Cys Asn Lys 225 230 235 240 Leu Gly Val Lys Cys Tyr Lys Met Pro Lys Val Glu Thr Val Val Gln 245 250 255 Gly Leu His Gln Ala Gly Thr Gly Phe Gln Lys Ile Asp Ile Thr Asp 260 265 270 Leu Leu Gly Arg Gln Glu Ile Arg Leu Asp Glu Ser Arg Leu Gly Ala 275 280 285 Glu Leu Thr Gly Lys Thr Ile Leu Val Thr Gly Ala Gly Gly Ser Ile 290 295 300 Gly Ser Glu Ile Cys Arg Gln Val Ser Arg Phe Asn Pro Glu Arg Ile 305 310 315 320 Val Leu Leu Gly His Gly Glu Asn Ser Ile Tyr Leu Val Tyr His Glu 325 330 335 Leu Ile Arg Lys Phe Gln Gly Ile Asp Tyr Val Pro Val Ile Ala Asp 340 345 350 Ile Gln Asp Tyr Asp Arg Leu Leu Gln Val Phe Glu Gln Tyr Lys Pro 355 360 365 Ala Ile Val Tyr His Ala Ala Ala His Lys His Val Pro Met Met Glu 370 375 380 Arg Asn Pro Lys Glu Ala Phe Lys Asn Asn Ile Arg Gly Thr Tyr Asn 385 390 395 400 Val Ala Lys Ala Val Asp Glu Ala Lys Val Ser Lys Met Val Met Ile 405 410 415 Ser Thr Asp Lys Ala Val Asn Pro Pro Asn Val Met Gly Ala Thr Lys 420 425 430 Arg Val Ala Glu Leu Ile Val Thr Gly Phe Asn Gln Arg Ser Gln Ser 435 440 445 Thr Tyr Cys Ala Val Arg Phe Gly Asn Val Leu Gly Ser Arg Gly Ser 450 455 460 Val Ile Pro Val Phe Glu Arg Gln Ile Ala Glu Gly Gly Pro Val Thr 465 470 475 480 Val Thr Asp Phe Arg Met Thr Arg Tyr Phe Met Thr Ile Pro Glu Ala 485 490 495 Ser Arg Leu Val Ile His Ala Gly Ala Tyr Ala Lys Asp Gly Glu Val 500 505 510 Phe Ile Leu Asp Met Gly Lys Pro Val Lys Ile Tyr Asp Leu Ala Lys 515 520 525 Lys Met Val Leu Leu Ser Gly His Thr Glu Ser Glu Ile Pro Ile Val 530 535 540 Glu Val Gly Ile Arg Pro Gly Glu Lys Leu Tyr Glu Glu Leu Leu Val 545 550 555 560 Ser Thr Glu Leu Val Asp Asn Gln Val Met Asp Lys Ile Phe Val Gly 565 570 575 Lys Val Asn Val Met Pro Leu Glu Ser Ile Asn Gln Lys Ile Gly Glu 580 585 590 Phe Arg Thr Leu Ser Gly Asp Glu Leu Lys Gln Ala Ile Ile Ala Phe 595 600 605 Ala Asn Gln Thr Thr His Ile Glu 610 615 105 1338 DNA Streptococcus pneumoniae 105 atgattgaac tttatgatag ttacagtcaa gaaagtcgag atttacatga aagtctagtc 60 gctactggtc tttctcaact tggagtggtc atcgatgcag atggttttct gcctgatggt 120 ctgctttctc cttttaccta ttatctaggt tacgaggatg gaaaacctct ctattttaat 180 caagttcccg tttcagattt ttgggaaatt ttaggagata atcagtctgc ttgtattgaa 240 gatgtgacgc aggagagggc tgtcattcat tatgctgatg gaatgcaggc tcgcttggtt 300 aaacaggtag actggaaaga cctagaaggt cgagtacgtc aggttgacca ctacaatcgc 360 ttcggagctt gttttgctac aacgacttat agcgcagata gcgagccgat tatgacagtt 420 taccaagatg tcaatggtca acaagtttta ctggaaaacc atgtgacggg tgatatctta 480 ttgactttgc caggtcagtc catgcgttac tttgcaaata aagttgaatt tatcaccttc 540 tttttgcaag atttggaaat agataccagt cagcttatct ttaatactct agcgactcct 600 ttcttggttt ccttccatca tccagataaa tctggctcgg atgtcttggt atggcaggaa 660 cctctctatg atgccattcc aggtaatatg cagttgattt tggaaagtga taatgtgcgt 720 actaagaaga tcatcattcc aaataaggcg acttatgagc gcgctttaga gttaactgac 780 gagaaatacc atgatcagtt tgtgcacttg ggttatcatt accagttcaa acgtgataat 840 ttcctaagac gagatgcctt aatcttgacc aattcagatc agattgagca agtagaagca 900 atcgcaggag ccttgcctga tgtcactttc cgtattgcag cggtgacaga gatgtcttct 960 aagctcttag acatgctttg ctatcctaat gtggcccttt accagaacgc tagtccacag 1020 aagattcagg agctgtatca actgtcggat atttacttgg atataaacca cagtaatgag 1080 ttgctacagg cagtgcgtca ggcctttgag cacaatctct tgattcttgg ctttaatcag 1140 acggtgcaca atagacttta tatcgctcca gaccatctat ttgaaagtag tgaagttgct 1200 gctttggttg agaccattaa attggccctt tcagatgttg atcaaatgcg tcaggcactt 1260 ggcaaacaag gccaacatgc aaattatgtt gacttggtga gatatcagga aaccatgcaa 1320 actgttttag gaggctaa 1338 106 445 PRT Streptococcus pneumoniae 106 Met Ile Glu Leu Tyr Asp Ser Tyr Ser Gln Glu Ser Arg Asp Leu His 1 5 10 15 Glu Ser Leu Val Ala Thr Gly Leu Ser Gln Leu Gly Val Val Ile Asp 20 25 30 Ala Asp Gly Phe Leu Pro Asp Gly Leu Leu Ser Pro Phe Thr Tyr Tyr 35 40 45 Leu Gly Tyr Glu Asp Gly Lys Pro Leu Tyr Phe Asn Gln Val Pro Val 50 55 60 Ser Asp Phe Trp Glu Ile Leu Gly Asp Asn Gln Ser Ala Cys Ile Glu 65 70 75 80 Asp Val Thr Gln Glu Arg Ala Val Ile His Tyr Ala Asp Gly Met Gln 85 90 95 Ala Arg Leu Val Lys Gln Val Asp Trp Lys Asp Leu Glu Gly Arg Val 100 105 110 Arg Gln Val Asp His Tyr Asn Arg Phe Gly Ala Cys Phe Ala Thr Thr 115 120 125 Thr Tyr Ser Ala Asp Ser Glu Pro Ile Met Thr Val Tyr Gln Asp Val 130 135 140 Asn Gly Gln Gln Val Leu Leu Glu Asn His Val Thr Gly Asp Ile Leu 145 150 155 160 Leu Thr Leu Pro Gly Gln Ser Met Arg Tyr Phe Ala Asn Lys Val Glu 165 170 175 107 1512 DNA Streptococcus pneumoniae 107 atgacaattt acaatataaa tttaggaatt ggttgggcta gtagcggtgt tgaatacgct 60 caagcctatc gtgctggtgt ttttcggaaa ttaaatctgt cctctaagtt tatctttaca 120 gatatgattt tagccgataa tattcagcac ttaacagcca atattggttt tgatgataat 180 caggttatct ggctttataa tcatttcaca gatatcaaaa ttgcacctac tagcgtgaca 240 gtggatgatg tcttggctta ctttggtggt gaagaaagtc acagagaaaa aaatggcaag 300 gttttacgtg tattcttttt tgaccaagat aagtttgtaa cctgttattt ggttgatgag 360 aacaaggact tggttcaaca tgccgagtat gtttttaagg gaaacctgat tcggaaggat 420 tacttttctt atacgcgtta ttgtagcgag tattttgctc ccaaggacaa tgttgcagtc 480 ttataccaac gaacttttta taatgaagac gggactccag tctatgatat cttgatgaat 540 caagggaagg aagaagttta tcatttcaag gataagattt tctatggaaa gcaagctttt 600 gtgcgtgcct ttatgaaatc tttgaatttg aataagtctg atttggtcat tctcgatagg 660 gagacaggta ttggacaggt tgtgtttgag gaagcacaga cagcacatct agcggtagtt 720 gttcatgcgg agcattatag tgaaaatgct acaaatgagg actatatcct ttggaataac 780 tattatgact atcagtttac caatgcagat aaggttgact tctttatcgt gtctactgat 840 agacaaaatg aagttctaca agagcaattt gccaaatata ctcagcatca gccaaagatt 900 gttaccattc ctgtaggcag tattgattcc ttgacagatt caagtcaagg gcgcaaacca 960 ttttcattga ttacggcttc acgtcttgcc aaagaaaagc acattgattg gcttgtgaaa 1020 gctgtgattg aagctcataa ggagttaccg gaactaacct ttgatatcta tggtagtggt 1080 ggagaagatt ctctgcttag agaaattatt gcaaatcatc aggcagagga ctatatccaa 1140 ctcaaggggc atgcggaact ttcgcagatt tatagccagt atgaggtcta cttaacggct 1200 tctaccagcg aaggatttgg tctgaccttg atggaagcta ttggttcagg tctacctcta 1260 attggttttg atgtgcctta tggtaatcag acctttatag aggatgggca aaatggttat 1320 ttgattccaa gttcatctga ccatgtagaa gaccaaatca agcaagctta tgccgctaag 1380 atttgtcaat tgtatcaaga aaatcgtttg gaagctatgc gtgcctattc ttaccaaatt 1440 gcagaaggct tcttgaccaa agaaatttta gaaaagtgga agaaaacagt agaggaggtg 1500 ctccatgatt ga 1512 108 503 PRT Streptococcus pneumoniae 108 Met Thr Ile Tyr Asn Ile Asn Leu Gly Ile Gly Trp Ala Ser Ser Gly 1 5 10 15 Val Glu Tyr Ala Gln Ala Tyr Arg Ala Gly Val Phe Arg Lys Leu Asn 20 25 30 Leu Ser Ser Lys Phe Ile Phe Thr Asp Met Ile Leu Ala Asp Asn Ile 35 40 45 Gln His Leu Thr Ala Asn Ile Gly Phe Asp Asp Asn Gln Val Ile Trp 50 55 60 Leu Tyr Asn His Phe Thr Asp Ile Lys Ile Ala Pro Thr Ser Val Thr 65 70 75 80 Val Asp Asp Val Leu Ala Tyr Phe Gly Gly Glu Glu Ser His Arg Glu 85 90 95 Lys Asn Gly Lys Val Leu Arg Val Phe Phe Phe Asp Gln Asp Lys Phe 100 105 110 Val Thr Cys Tyr Leu Val Asp Glu Asn Lys Asp Leu Val Gln His Ala 115 120 125 Glu Tyr Val Phe Lys Gly Asn Leu Ile Arg Lys Asp Tyr Phe Ser Tyr 130 135 140 Thr Arg Tyr Cys Ser Glu Tyr Phe Ala Pro Lys Asp Asn Val Ala Val 145 150 155 160 Leu Tyr Gln Arg Thr Phe Tyr Asn Glu Asp Gly Thr Pro Val Tyr Asp 165 170 175 Ile Leu Met Asn Gln Gly Lys Glu Glu Val Tyr His Phe Lys Asp Lys 180 185 190 Ile Phe Tyr Gly Lys Gln Ala Phe Val Arg Ala Phe Met Lys Ser Leu 195 200 205 Asn Leu Asn Lys Ser Asp Leu Val Ile Leu Asp Arg Glu Thr Gly Ile 210 215 220 Gly Gln Val Val Phe Glu Glu Ala Gln Thr Ala His Leu Ala Val Val 225 230 235 240 Val His Ala Glu His Tyr Ser Glu Asn Ala Thr Asn Glu Asp Tyr Ile 245 250 255 Leu Trp Asn Asn Tyr Tyr Asp Tyr Gln Phe Thr Asn Ala Asp Lys Val 260 265 270 Asp Phe Phe Ile Val Ser Thr Asp Arg Gln Asn Glu Val Leu Gln Glu 275 280 285 Gln Phe Ala Lys Tyr Thr Gln His Gln Pro Lys Ile Val Thr Ile Pro 290 295 300 Val Gly Ser Ile Asp Ser Leu Thr Asp Ser Ser Gln Gly Arg Lys Pro 305 310 315 320 Phe Ser Leu Ile Thr Ala Ser Arg Leu Ala Lys Glu Lys His Ile Asp 325 330 335 Trp Leu Val Lys Ala Val Ile Glu Ala His Lys Glu Leu Pro Glu Leu 340 345 350 Thr Phe Asp Ile Tyr Gly Ser Gly Gly Glu Asp Ser Leu Leu Arg Glu 355 360 365 Ile Ile Ala Asn His Gln Ala Glu Asp Tyr Ile Gln Leu Lys Gly His 370 375 380 Ala Glu Leu Ser Gln Ile Tyr Ser Gln Tyr Glu Val Tyr Leu Thr Ala 385 390 395 400 Ser Thr Ser Glu Gly Phe Gly Leu Thr Leu Met Glu Ala Ile Gly Ser 405 410 415 Gly Leu Pro Leu Ile Gly Phe Asp Val Pro Tyr Gly Asn Gln Thr Phe 420 425 430 Ile Glu Asp Gly Gln Asn Gly Tyr Leu Ile Pro Ser Ser Ser Asp His 435 440 445 Val Glu Asp Gln Ile Lys Gln Ala Tyr Ala Ala Lys Ile Cys Gln Leu 450 455 460 Tyr Gln Glu Asn Arg Leu Glu Ala Met Arg Ala Tyr Ser Tyr Gln Ile 465 470 475 480 Ala Glu Gly Phe Leu Thr Lys Glu Ile Leu Glu Lys Trp Lys Lys Thr 485 490 495 Val Glu Glu Val Leu His Asp 500 109 2292 DNA Streptococcus pneumoniae 109 atgtcctctc tttcggatca agaattagta gctaaaacag tagagtttcg tcagcgtctt 60 tccgagggag aaagtctaga cgatattttg gttgaagctt ttgctgtggt gcgtgaagca 120 gataagcgga ttttagggat gtttccttat gatgttcaag tcatgggagc tattgtcatg 180 cactatggaa atgttgctga gatgaatacg ggggaaggta agaccttgac agctaccatg 240 cctgtctatt tgaacgcttt ttcaggagaa ggagtgatgg ttgtgactcc taatgagtat 300 ttatcaaagc gtgatgccga ggaaatgggt caagtttatc gttttctagg attgaccatt 360 ggtgtaccat ttacggaaga tccaaagaag gagatgaaag ctgaagaaaa gaagcttatc 420 tatgcttcgg atatcatcta cacaaccaat agtaatttag gttttgatta tctaaatgat 480 aacctagcct cgaatgaaga aggtaagttt ttacgaccgt ttaactatgt gattattgat 540 gaaattgatg atatcttgct tgatagtgca caaactcctc tgattattgc gggttctcct 600 cgtgttcagt ctaattacta tgcgatcatt gatacacttg taacaacctt ggtcgaagga 660 gaggattata tctttaaaga ggagaaagag gaggtttggc tcactactaa gggggccaag 720 tctgctgaga atttcctagg gattgataat ttatacaagg aagagcatgc gtcttttgct 780 cgtcatttgg tttatgcgat tcgagctcat aagctcttta ctaaagataa ggactatatc 840 attcgtggaa atgagatggt actggttgat aagggaacag ggcgtctaat ggaaatgact 900 aaacttcaag gaggtctcca tcaggctatt gaagccaagg aacatgtcaa attatctcct 960 gagacgcggg ctatggcctc gatcacctat cagagtcttt ttaagatgtt taataagata 1020 tctggtatga cagggacagg taaggtcgcg gaaaaagagt ttattgaaac ttacaatatg 1080 tctgtagtac gcattccaac caatcgtccg agacaacgga ttgactatcc agataatcta 1140 tatatcactt tacctgaaaa agtgtatgca tccttggagt acatcaagca ataccatgct 1200 aagggaaatc ctttactcgt ttttgtaggc tcagttgaaa tgtctcaact ctattcgtct 1260 ctcttgtttc gtgaagggat tgcccataat gtcctaaatg ctaataatgc ggcgcgtgag 1320 gctcagatta tctccgagtc aggtcagatg ggggctgtga cagtggctac ctctatggca 1380 ggacgtggta cggatatcaa gcttggtaaa ggagtcgcag agcttggggg cttgattgtt 1440 attgggactg agcggatgga aagtcagcgg atcgacctac aaattcgtgg ccgttctggt 1500 cgtcagggag atcctggtat gagtaaattt tttgtatcct tagaggatga tgttatcaag 1560 aaatttggtc catcttgggt gcataaaaag tacaaagact atcaggttca agatatgact 1620 caaccggaag tattgaaagg tcgtaaatac cggaaactag tcgaaaaggc tcagcatgcc 1680 agtgatagtg ctggacgttc agcacgtcgt cagactctgg agtatgctga aagtatgaat 1740 atacaacggg atatagtcta taaagagaga aatcgtctaa tagatggttc tcgtgactta 1800 gaggatgttg ttgtggatat cattgagaga tatacagaag aggtagcggc tgatcactat 1860 gctagtcgtg aattattgtt tcactttatt gtgaccaata ttagttttca tgttaaagag 1920 gttccagatt atatagatgt aactgacaaa actgcagttc gtagctttat gaagcaggtg 1980 attgataaag aactttctga aaagaaagaa ttacttaatc aacatgactt atatgaacag 2040 tttttacgac tttcactgct taaagccatt gatgacaact gggtagagca ggtagactat 2100 ctacaacagc tatccatggc tatcggtggt caatctgcta gtcagaaaaa tccaatcgta 2160 gagtactatc aagaagccta cgcgggcttt gaagctatga aagaacagat tcatgcggat 2220 atggtgcgta atctcctgat ggggctggtt gaggtcactc caaaaggtga aatcgtgact 2280 cattttccat aa 2292 110 763 PRT Streptococcus pneumoniae 110 Met Ser Ser Leu Ser Asp Gln Glu Leu Val Ala Lys Thr Val Glu Phe 1 5 10 15 Arg Gln Arg Leu Ser Glu Gly Glu Ser Leu Asp Asp Ile Leu Val Glu 20 25 30 Ala Phe Ala Val Val Arg Glu Ala Asp Lys Arg Ile Leu Gly Met Phe 35 40 45 Pro Tyr Asp Val Gln Val Met Gly Ala Ile Val Met His Tyr Gly Asn 50 55 60 Val Ala Glu Met Asn Thr Gly Glu Gly Lys Thr Leu Thr Ala Thr Met 65 70 75 80 Pro Val Tyr Leu Asn Ala Phe Ser Gly Glu Gly Val Met Val Val Thr 85 90 95 Pro Asn Glu Tyr Leu Ser Lys Arg Asp Ala Glu Glu Met Gly Gln Val 100 105 110 Tyr Arg Phe Leu Gly Leu Thr Ile Gly Val Pro Phe Thr Glu Asp Pro 115 120 125 Lys Lys Glu Met Lys Ala Glu Glu Lys Lys Leu Ile Tyr Ala Ser Asp 130 135 140 Ile Ile Tyr Thr Thr Asn Ser Asn Leu Gly Phe Asp Tyr Leu Asn Asp 145 150 155 160 Asn Leu Ala Ser Asn Glu Glu Gly Lys Phe Leu Arg Pro Phe Asn Tyr 165 170 175 Val Ile Ile Asp Glu Ile Asp Asp Ile Leu Leu Asp Ser Ala Gln Thr 180 185 190 Pro Leu Ile Ile Ala Gly Ser Pro Arg Val Gln Ser Asn Tyr Tyr Ala 195 200 205 Ile Ile Asp Thr Leu Val Thr Thr Leu Val Glu Gly Glu Asp Tyr Ile 210 215 220 Phe Lys Glu Glu Lys Glu Glu Val Trp Leu Thr Thr Lys Gly Ala Lys 225 230 235 240 Ser Ala Glu Asn Phe Leu Gly Ile Asp Asn Leu Tyr Lys Glu Glu His 245 250 255 Ala Ser Phe Ala Arg His Leu Val Tyr Ala Ile Arg Ala His Lys Leu 260 265 270 Phe Thr Lys Asp Lys Asp Tyr Ile Ile Arg Gly Asn Glu Met Val Leu 275 280 285 Val Asp Lys Gly Thr Gly Arg Leu Met Glu Met Thr Lys Leu Gln Gly 290 295 300 Gly Leu His Gln Ala Ile Glu Ala Lys Glu His Val Lys Leu Ser Pro 305 310 315 320 Glu Thr Arg Ala Met Ala Ser Ile Thr Tyr Gln Ser Leu Phe Lys Met 325 330 335 Phe Asn Lys Ile Ser Gly Met Thr Gly Thr Gly Lys Val Ala Glu Lys 340 345 350 Glu Phe Ile Glu Thr Tyr Asn Met Ser Val Val Arg Ile Pro Thr Asn 355 360 365 Arg Pro Arg Gln Arg Ile Asp Tyr Pro Asp Asn Leu Tyr Ile Thr Leu 370 375 380 Pro Glu Lys Val Tyr Ala Ser Leu Glu Tyr Ile Lys Gln Tyr His Ala 385 390 395 400 Lys Gly Asn Pro Leu Leu Val Phe Val Gly Ser Val Glu Met Ser Gln 405 410 415 Leu Tyr Ser Ser Leu Leu Phe Arg Glu Gly Ile Ala His Asn Val Leu 420 425 430 Asn Ala Asn Asn Ala Ala Arg Glu Ala Gln Ile Ile Ser Glu Ser Gly 435 440 445 Gln Met Gly Ala Val Thr Val Ala Thr Ser Met Ala Gly Arg Gly Thr 450 455 460 Asp Ile Lys Leu Gly Lys Gly Val Ala Glu Leu Gly Gly Leu Ile Val 465 470 475 480 Ile Gly Thr Glu Arg Met Glu Ser Gln Arg Ile Asp Leu Gln Ile Arg 485 490 495 Gly Arg Ser Gly Arg Gln Gly Asp Pro Gly Met Ser Lys Phe Phe Val 500 505 510 Ser Leu Glu Asp Asp Val Ile Lys Lys Phe Gly Pro Ser Trp Val His 515 520 525 Lys Lys Tyr Lys Asp Tyr Gln Val Gln Asp Met Thr Gln Pro Glu Val 530 535 540 Leu Lys Gly Arg Lys Tyr Arg Lys Leu Val Glu Lys Ala Gln His Ala 545 550 555 560 Ser Asp Ser Ala Gly Arg Ser Ala Arg Arg Gln Thr Leu Glu Tyr Ala 565 570 575 Glu Ser Met Asn Ile Gln Arg Asp Ile Val Tyr Lys Glu Arg Asn Arg 580 585 590 Leu Ile Asp Gly Ser Arg Asp Leu Glu Asp Val Val Val Asp Ile Ile 595 600 605 Glu Arg Tyr Thr Glu Glu Val Ala Ala Asp His Tyr Ala Ser Arg Glu 610 615 620 Leu Leu Phe His Phe Ile Val Thr Asn Ile Ser Phe His Val Lys Glu 625 630 635 640 Val Pro Asp Tyr Ile Asp Val Thr Asp Lys Thr Ala Val Arg Ser Phe 645 650 655 Met Lys Gln Val Ile Asp Lys Glu Leu Ser Glu Lys Lys Glu Leu Leu 660 665 670 Asn Gln His Asp Leu Tyr Glu Gln Phe Leu Arg Leu Ser Leu Leu Lys 675 680 685 Ala Ile Asp Asp Asn Trp Val Glu Gln Val Asp Tyr Leu Gln Gln Leu 690 695 700 Ser Met Ala Ile Gly Gly Gln Ser Ala Ser Gln Lys Asn Pro Ile Val 705 710 715 720 Glu Tyr Tyr Gln Glu Ala Tyr Ala Gly Phe Glu Ala Met Lys Glu Gln 725 730 735 Ile His Ala Asp Met Val Arg Asn Leu Leu Met Gly Leu Val Glu Val 740 745 750 Thr Pro Lys Gly Glu Ile Val Thr His Phe Pro 755 760 111 879 DNA Streptococcus pneumoniae 111 atgaaacaag aatggtttga aagtaatgat tttgtaaaaa caacaagcaa gaacaagcct 60 gaagagcaag ctcaagaggt tgcagacaag gctgaagaaa ggatacccga tctcgataca 120 ccaattgaaa aaaatactca gttagaggag gaagtctctc aagctgaagt cgaattggaa 180 agccagcaag aagagaaaat tgaagctcct gaagacagtg aagcgagaac agaaatagaa 240 gaaaagaagg catctaattc tactgaagaa gagccagacc tttctaaaga aacagaaaaa 300 gtcactatag ctgaagagag ccaagaagct cttcctcagc aaaaagcaac cacgaaagag 360 ccacttctta tcagtaaatc tttagaaagt ccttatatcc ccgaccaagc tccaaaatct 420 agggataaat ggaaagagca agtgcttgat ttttggtctt ggctagtgga agcgatcaaa 480 tctcctacaa gtaagttgga aacaagtatc acacacagtt acacagcctt tctcttgctc 540 attctgtttt ctgcatcttc ctttttcttt agtatctatc acatcaaaca tgcttactat 600 ggacatatag caagcattaa cagtcgcttc cctgagcagc tagctccttt aactcttttt 660 tctatcatct ctatcctagt agcgacaaca ctcttcttct tttcattcct cttgggtagt 720 ttcgttgtga gacgatttat ccaccaggaa aaggactgga cgctagacaa ggttctccaa 780 caatatagtc aactcttggc aattccaatc tcctcactgc tattgctagt ttctttgctt 840 tctttgatag cctacgattt acagccctct tgtgtgtga 879 112 292 PRT Streptococcus pneumoniae 112 Met Lys Gln Glu Trp Phe Glu Ser Asn Asp Phe Val Lys Thr Thr Ser 1 5 10 15 Lys Asn Lys Pro Glu Glu Gln Ala Gln Glu Val Ala Asp Lys Ala Glu 20 25 30 Glu Arg Ile Pro Asp Leu Asp Thr Pro Ile Glu Lys Asn Thr Gln Leu 35 40 45 Glu Glu Glu Val Ser Gln Ala Glu Val Glu Leu Glu Ser Gln Gln Glu 50 55 60 Glu Lys Ile Glu Ala Pro Glu Asp Ser Glu Ala Arg Thr Glu Ile Glu 65 70 75 80 Glu Lys Lys Ala Ser Asn Ser Thr Glu Glu Glu Pro Asp Leu Ser Lys 85 90 95 Glu Thr Glu Lys Val Thr Ile Ala Glu Glu Ser Gln Glu Ala Leu Pro 100 105 110 Gln Gln Lys Ala Thr Thr Lys Glu Pro Leu Leu Ile Ser Lys Ser Leu 115 120 125 Glu Ser Pro Tyr Ile Pro Asp Gln Ala Pro Lys Ser Arg Asp Lys Trp 130 135 140 Lys Glu Gln Val Leu Asp Phe Trp Ser Trp Leu Val Glu Ala Ile Lys 145 150 155 160 Ser Pro Thr Ser Lys Leu Glu Thr Ser Ile Thr His Ser Tyr Thr Ala 165 170 175 Phe Leu Leu Leu Ile Leu Phe Ser Ala Ser Ser Phe Phe Phe Ser Ile 180 185 190 Tyr His Ile Lys His Ala Tyr Tyr Gly His Ile Ala Ser Ile Asn Ser 195 200 205 Arg Phe Pro Glu Gln Leu Ala Pro Leu Thr Leu Phe Ser Ile Ile Ser 210 215 220 Ile Leu Val Ala Thr Thr Leu Phe Phe Phe Ser Phe Leu Leu Gly Ser 225 230 235 240 Phe Val Val Arg Arg Phe Ile His Gln Glu Lys Asp Trp Thr Leu Asp 245 250 255 Lys Val Leu Gln Gln Tyr Ser Gln Leu Leu Ala Ile Pro Ile Ser Ser 260 265 270 Leu Leu Leu Leu Val Ser Leu Leu Ser Leu Ile Ala Tyr Asp Leu Gln 275 280 285 Pro Ser Cys Val 290 113 327 DNA Streptococcus pneumoniae 113 atgtactttc caacatcctc tgccttgatt gaatttctca tcttggctgt actggagcag 60 ggtgattctt atggttatga gattagccaa accattaagc tgatcgctaa tatcaaagaa 120 tccacactct atcccattct caaaaaattg gaaggcaata gctttctgac aacctattct 180 agagagttcc aaggtcgcat gcgcaaatac tactccttga caaacggtgg tatagagcag 240 ctcttgaccc taaaagatga atgggcactc tatacagaca ccatcaatgg catcatagaa 300 gggagtatcc gccatgacaa gaactga 327 114 108 PRT Streptococcus pneumoniae 114 Met Tyr Phe Pro Thr Ser Ser Ala Leu Ile Glu Phe Leu Ile Leu Ala 1 5 10 15 Val Leu Glu Gln Gly Asp Ser Tyr Gly Tyr Glu Ile Ser Gln Thr Ile 20 25 30 Lys Leu Ile Ala Asn Ile Lys Glu Ser Thr Leu Tyr Pro Ile Leu Lys 35 40 45 Lys Leu Glu Gly Asn Ser Phe Leu Thr Thr Tyr Ser Arg Glu Phe Gln 50 55 60 Gly Arg Met Arg Lys Tyr Tyr Ser Leu Thr Asn Gly Gly Ile Glu Gln 65 70 75 80 Leu Leu Thr Leu Lys Asp Glu Trp Ala Leu Tyr Thr Asp Thr Ile Asn 85 90 95 Gly Ile Ile Glu Gly Ser Ile Arg His Asp Lys Asn 100 105 115 954 DNA Streptococcus pneumoniae 115 atggattttg aaaaaattga acaagcttat atctatttac tagagaatgt ccaagtcatc 60 caaagtgatt tggcgaccaa cttttatgac gccttggtgg agcaaaatag catctatctg 120 gatggtgaaa ctgagctaaa ccaggtcaaa gacaacaatc aggcccttaa gcgtttagca 180 ctacgcaaag aagaatggct caagacctac cagtttctct tgatgaaggc tgggcaaaca 240 gaacccttgc aggccaatca ccagtttaca ccggatgcta ttgctttgct tttggtgttt 300 attgtggaag agttgtttaa agaggaggaa attactatcc tcgaaatggg ttctgggatg 360 ggaattctag gcgctatttt cttgacctcg cttactaaaa aggtggatta cttgggaatg 420 gaagtggatg atttgctgat tgatctggca gctagcatgg cagatgtaat tggtttgcag 480 gctggctttg tccaaggaga tgccgttcgc ccacaaatgc tcaaagaaag cgatgtggtc 540 atcagtgact tgcctgtcgg ctattatcct gatgatgccg ttgcgtcgcg ccatcaagtt 600 gcttctagcc aagaacatac ttacgcccat cacttgctca tggaacaagg gcttaagtac 660 ctcaagtcag acggatacgc tatttttcta gctccgagtg atttgttgac cagtcctcaa 720 agtgatttgt taaaagaatg gctgaaagaa gaggcgagtc tggttgctat gattagtctg 780 cctgaaaatc tctttgctaa tgccaaacaa tctaagacta tttttatctt acagaagaaa 840 aatgaaatag cagtagagcc ttttgtttat ccacttgcta gcttgcaaga tgcaagtgtt 900 ttaatgaaat ttaaagaaaa ttttcaaaaa tggactcaag gtactgaaat ataa 954 116 317 PRT Streptococcus pneumoniae 116 Met Asp Phe Glu Lys Ile Glu Gln Ala Tyr Ile Tyr Leu Leu Glu Asn 1 5 10 15 Val Gln Val Ile Gln Ser Asp Leu Ala Thr Asn Phe Tyr Asp Ala Leu 20 25 30 Val Glu Gln Asn Ser Ile Tyr Leu Asp Gly Glu Thr Glu Leu Asn Gln 35 40 45 Val Lys Asp Asn Asn Gln Ala Leu Lys Arg Leu Ala Leu Arg Lys Glu 50 55 60 Glu Trp Leu Lys Thr Tyr Gln Phe Leu Leu Met Lys Ala Gly Gln Thr 65 70 75 80 Glu Pro Leu Gln Ala Asn His Gln Phe Thr Pro Asp Ala Ile Ala Leu 85 90 95 Leu Leu Val Phe Ile Val Glu Glu Leu Phe Lys Glu Glu Glu Ile Thr 100 105 110 Ile Leu Glu Met Gly Ser Gly Met Gly Ile Leu Gly Ala Ile Phe Leu 115 120 125 Thr Ser Leu Thr Lys Lys Val Asp Tyr Leu Gly Met Glu Val Asp Asp 130 135 140 Leu Leu Ile Asp Leu Ala Ala Ser Met Ala Asp Val Ile Gly Leu Gln 145 150 155 160 Ala Gly Phe Val Gln Gly Asp Ala Val Arg Pro Gln Met Leu Lys Glu 165 170 175 Ser Asp Val Val Ile Ser Asp Leu Pro Val Gly Tyr Tyr Pro Asp Asp 180 185 190 Ala Val Ala Ser Arg His Gln Val Ala Ser Ser Gln Glu His Thr Tyr 195 200 205 Ala His His Leu Leu Met Glu Gln Gly Leu Lys Tyr Leu Lys Ser Asp 210 215 220 Gly Tyr Ala Ile Phe Leu Ala Pro Ser Asp Leu Leu Thr Ser Pro Gln 225 230 235 240 Ser Asp Leu Leu Lys Glu Trp Leu Lys Glu Glu Ala Ser Leu Val Ala 245 250 255 Met Ile Ser Leu Pro Glu Asn Leu Phe Ala Asn Ala Lys Gln Ser Lys 260 265 270 Thr Ile Phe Ile Leu Gln Lys Lys Asn Glu Ile Ala Val Glu Pro Phe 275 280 285 Val Tyr Pro Leu Ala Ser Leu Gln Asp Ala Ser Val Leu Met Lys Phe 290 295 300 Lys Glu Asn Phe Gln Lys Trp Thr Gln Gly Thr Glu Ile 305 310 315 117 1902 DNA Streptococcus pneumoniae 117 atgattattt tacaagctaa taaaattgaa cgttcttttg caggagaggt tcttttcgat 60 aatatcaacc tgcaggttga tgaacgagat cggattgctc ttgttgggaa aaatggtgca 120 ggtaagtcta ctcttttgaa gattttagtt ggagaagagg agccaactag cggagaaatc 180 aataagaaaa aagatatttc tctgtcttac ctagcccaag atagccgttt tgagtctgaa 240 aataccatct acgatgaaat gcttcatgtc tttaatgatt tgcgtcggac ggagagacaa 300 ctgcgtcaga tggagctgga gatgggtgaa aagtctggtg aggatttgga taaactgatg 360 tcagattatg accgcttatc tgagaatttt cgccaagcag gtggctttac ctatgaagct 420 gatattcgag cgattttgaa tggattcaag tttgacgagt ctatgtggca gatgaaaatt 480 gctgagcttt ctggtggtca aaatactcgt ttggcacttg ccaaaatgct ccttgaaaag 540 cccaatctct tggtcttgga cgagccaact aaccacttgg atattgaaac catcgcctgg 600 ctagagaatt acttggtaaa ctatagcggt gccctcatta tcgtcagcca cgaccgttat 660 ttcttggaca aggttgcgac aattacgcta gatttgacca agcattcctt ggatcgctat 720 gtggggaatt actctcgttt tgtcgaattg aaggagcaaa agctagttac tgaggcaaaa 780 aactatgaaa agcaacagaa ggaaatcgct gctctggaag actttgtcaa tcgcaatcta 840 gttcgtgctt caacgactaa acgtgctcaa tctcgccgta aacaactaga aaaaatggag 900 cgtttggaca agcctgaagc tggcaagaaa gcagccaaca tgaccttcca gtctgaaaaa 960 acgtcgggca atgttgtttt gactgttgaa aatgcagctg ttggctatga cggggaagtc 1020 ttgtcacaac ctatcaacct agatcttcgt aagatgaatg ctgtcgctat cgttggtcca 1080 aatggtatcg gcaagtcaac ctttatcaag tctattgtgg accagattcc ttttatcaag 1140 ggagaaaagc gctttggcgc taatgttgag gttggttact atgaccaaac ccaaagcaag 1200 ctgacaccaa gtaatacggt gctggatgaa ctctggaatg atttcaaact gacaccagaa 1260 gttgaaatcc gcaaccgtct tggagccttc cttttctcag gagatgatgt taaaaaatca 1320 gtcggcatgc tatctggtgg cgaaaaagct cgtttgcttt tagctaaatt gtctatggaa 1380 aacaataact ttttgattct ggatgagccg accaaccact tggatattga tagtaaggaa 1440 gtgctagaaa atgccttgat tgactttgat ggaaccttgc tgtttgtcag tcatgatcgt 1500 tactttatca atcgtgtggc aactcatgtt ttggaattgt ctgagaatgg ttcaactctc 1560 taccttggag attacgacta ctatgttgag aagaaagcaa cagcagaaat gagtcagact 1620 gaggaagctt caactagcaa tcaagcaaag gaagcaagtc cagtcaatga ctatcaggcc 1680 cagaaagaaa gtcaaaaaga agttcgcaaa ctcatgcgac aaatcgaaag tctagaagct 1740 gaaattgaag agctagaaag tcaaagccaa gccatttctg aacaaatgtt ggaaacaaac 1800 gatgccgaca aactcatgga attacaggct gagctggaca aaatcagcca tcgtcaggaa 1860 gaagctatgc ttgagtggga agaattatca gagcaggtgt aa 1902 118 633 PRT Streptococcus pneumoniae 118 Met Ile Ile Leu Gln Ala Asn Lys Ile Glu Arg Ser Phe Ala Gly Glu 1 5 10 15 Val Leu Phe Asp Asn Ile Asn Leu Gln Val Asp Glu Arg Asp Arg Ile 20 25 30 Ala Leu Val Gly Lys Asn Gly Ala Gly Lys Ser Thr Leu Leu Lys Ile 35 40 45 Leu Val Gly Glu Glu Glu Pro Thr Ser Gly Glu Ile Asn Lys Lys Lys 50 55 60 Asp Ile Ser Leu Ser Tyr Leu Ala Gln Asp Ser Arg Phe Glu Ser Glu 65 70 75 80 Asn Thr Ile Tyr Asp Glu Met Leu His Val Phe Asn Asp Leu Arg Arg 85 90 95 Thr Glu Arg Gln Leu Arg Gln Met Glu Leu Glu Met Gly Glu Lys Ser 100 105 110 Gly Glu Asp Leu Asp Lys Leu Met Ser Asp Tyr Asp Arg Leu Ser Glu 115 120 125 Asn Phe Arg Gln Ala Gly Gly Phe Thr Tyr Glu Ala Asp Ile Arg Ala 130 135 140 Ile Leu Asn Gly Phe Lys Phe Asp Glu Ser Met Trp Gln Met Lys Ile 145 150 155 160 Ala Glu Leu Ser Gly Gly Gln Asn Thr Arg Leu Ala Leu Ala Lys Met 165 170 175 Leu Leu Glu Lys Pro Asn Leu Leu Val Leu Asp Glu Pro Thr Asn His 180 185 190 Leu Asp Ile Glu Thr Ile Ala Trp Leu Glu Asn Tyr Leu Val Asn Tyr 195 200 205 Ser Gly Ala Leu Ile Ile Val Ser His Asp Arg Tyr Phe Leu Asp Lys 210 215 220 Val Ala Thr Ile Thr Leu Asp Leu Thr Lys His Ser Leu Asp Arg Tyr 225 230 235 240 Val Gly Asn Tyr Ser Arg Phe Val Glu Leu Lys Glu Gln Lys Leu Val 245 250 255 Thr Glu Ala Lys Asn Tyr Glu Lys Gln Gln Lys Glu Ile Ala Ala Leu 260 265 270 Glu Asp Phe Val Asn Arg Asn Leu Val Arg Ala Ser Thr Thr Lys Arg 275 280 285 Ala Gln Ser Arg Arg Lys Gln Leu Glu Lys Met Glu Arg Leu Asp Lys 290 295 300 Pro Glu Ala Gly Lys Lys Ala Ala Asn Met Thr Phe Gln Ser Glu Lys 305 310 315 320 Thr Ser Gly Asn Val Val Leu Thr Val Glu Asn Ala Ala Val Gly Tyr 325 330 335 Asp Gly Glu Val Leu Ser Gln Pro Ile Asn Leu Asp Leu Arg Lys Met 340 345 350 Asn Ala Val Ala Ile Val Gly Pro Asn Gly Ile Gly Lys Ser Thr Phe 355 360 365 Ile Lys Ser Ile Val Asp Gln Ile Pro Phe Ile Lys Gly Glu Lys Arg 370 375 380 Phe Gly Ala Asn Val Glu Val Gly Tyr Tyr Asp Gln Thr Gln Ser Lys 385 390 395 400 Leu Thr Pro Ser Asn Thr Val Leu Asp Glu Leu Trp Asn Asp Phe Lys 405 410 415 Leu Thr Pro Glu Val Glu Ile Arg Asn Arg Leu Gly Ala Phe Leu Phe 420 425 430 Ser Gly Asp Asp Val Lys Lys Ser Val Gly Met Leu Ser Gly Gly Glu 435 440 445 Lys Ala Arg Leu Leu Leu Ala Lys Leu Ser Met Glu Asn Asn Asn Phe 450 455 460 Leu Ile Leu Asp Glu Pro Thr Asn His Leu Asp Ile Asp Ser Lys Glu 465 470 475 480 Val Leu Glu Asn Ala Leu Ile Asp Phe Asp Gly Thr Leu Leu Phe Val 485 490 495 Ser His Asp Arg Tyr Phe Ile Asn Arg Val Ala Thr His Val Leu Glu 500 505 510 Leu Ser Glu Asn Gly Ser Thr Leu Tyr Leu Gly Asp Tyr Asp Tyr Tyr 515 520 525 Val Glu Lys Lys Ala Thr Ala Glu Met Ser Gln Thr Glu Glu Ala Ser 530 535 540 Thr Ser Asn Gln Ala Lys Glu Ala Ser Pro Val Asn Asp Tyr Gln Ala 545 550 555 560 Gln Lys Glu Ser Gln Lys Glu Val Arg Lys Leu Met Arg Gln Ile Glu 565 570 575 Ser Leu Glu Ala Glu Ile Glu Glu Leu Glu Ser Gln Ser Gln Ala Ile 580 585 590 Ser Glu Gln Met Leu Glu Thr Asn Asp Ala Asp Lys Leu Met Glu Leu 595 600 605 Gln Ala Glu Leu Asp Lys Ile Ser His Arg Gln Glu Glu Ala Met Leu 610 615 620 Glu Trp Glu Glu Leu Ser Glu Gln Val 625 630 119 1179 DNA Streptococcus pneumoniae 119 atgaatcgct atgcagtgca gttgattagc cgtggggcta tcaataaaat gggaaatatg 60 ctctatgatt atggaaatag tgtctggttg gcttctatgg ggactatagg acagacagtt 120 ttaggaatgt atcagatttc tgagctcgtc acatctattc tcgtcaatcc ctttggcgga 180 gttatttcag accgtttttc tcgtcgtaag attttaatga cggcagatct tgtttgtggg 240 attctttgtc tggctatttc tttcataagg aatgatagct ggatgattgg cgctttgatt 300 gttgctaaca ttgtgcaggc tattgctttt gccttttctc gcacagccaa taaagctatc 360 ataactgaag tggtggagaa agatgagatt gtgatctata attctcgctt agagctggtt 420 ttgcaggttg taggtgttag ctctcctgtt ctttccttcc ttgttttaca gtttgcaagt 480 ctccatatga cgctactgct agactcgctg acttttttca ttgcttttgt tctagtggct 540 ttccttccaa aagaggaagc aaaagttcaa gagaaaaagg cttttactgg gagagatatt 600 tttgtagata tcaaggatgg gttacactat atctggcatc agcaagaaat tttcttcctt 660 ttgctggtag cttccagcgt taatttcttt tttgcagctt ttgaatttct acttcccttt 720 tcgaatcagc tttacgggtc agaaggagcc tatgcaagta ttttaactat gggggctatt 780 ggttccatca ttggggctct tctagctagt aaaattaaag ctaatattta taatcttttg 840 attttactgg ctttgacagg tgtcggagtt tttatgatgg gattaccact tccaactttt 900 ctttcctttt ctggaaattt agtttgtgaa ttgtttatga cgatttttaa tattcacttt 960 tttactcaag tacaaaccaa ggttgagagc gaatttcttg gaagagtact gagtacaatt 1020 tttaccttag ctattctatt tatgcctatt gcaaaaggat ttatgacagt cttgccaagt 1080 gtccatcttt attctttctt gattattgga cttggagttg tagccttata tttcttagct 1140 ctcggatatg ttcgaactca ttttgaaaaa ttgatataa 1179 120 392 PRT Streptococcus pneumoniae 120 Met Asn Arg Tyr Ala Val Gln Leu Ile Ser Arg Gly Ala Ile Asn Lys 1 5 10 15 Met Gly Asn Met Leu Tyr Asp Tyr Gly Asn Ser Val Trp Leu Ala Ser 20 25 30 Met Gly Thr Ile Gly Gln Thr Val Leu Gly Met Tyr Gln Ile Ser Glu 35 40 45 Leu Val Thr Ser Ile Leu Val Asn Pro Phe Gly Gly Val Ile Ser Asp 50 55 60 Arg Phe Ser Arg Arg Lys Ile Leu Met Thr Ala Asp Leu Val Cys Gly 65 70 75 80 Ile Leu Cys Leu Ala Ile Ser Phe Ile Arg Asn Asp Ser Trp Met Ile 85 90 95 Gly Ala Leu Ile Val Ala Asn Ile Val Gln Ala Ile Ala Phe Ala Phe 100 105 110 Ser Arg Thr Ala Asn Lys Ala Ile Ile Thr Glu Val Val Glu Lys Asp 115 120 125 Glu Ile Val Ile Tyr Asn Ser Arg Leu Glu Leu Val Leu Gln Val Val 130 135 140 Gly Val Ser Ser Pro Val Leu Ser Phe Leu Val Leu Gln Phe Ala Ser 145 150 155 160 Leu His Met Thr Leu Leu Leu Asp Ser Leu Thr Phe Phe Ile Ala Phe 165 170 175 Val Leu Val Ala Phe Leu Pro Lys Glu Glu Ala Lys Val Gln Glu Lys 180 185 190 Lys Ala Phe Thr Gly Arg Asp Ile Phe Val Asp Ile Lys Asp Gly Leu 195 200 205 His Tyr Ile Trp His Gln Gln Glu Ile Phe Phe Leu Leu Leu Val Ala 210 215 220 Ser Ser Val Asn Phe Phe Phe Ala Ala Phe Glu Phe Leu Leu Pro Phe 225 230 235 240 Ser Asn Gln Leu Tyr Gly Ser Glu Gly Ala Tyr Ala Ser Ile Leu Thr 245 250 255 Met Gly Ala Ile Gly Ser Ile Ile Gly Ala Leu Leu Ala Ser Lys Ile 260 265 270 Lys Ala Asn Ile Tyr Asn Leu Leu Ile Leu Leu Ala Leu Thr Gly Val 275 280 285 Gly Val Phe Met Met Gly Leu Pro Leu Pro Thr Phe Leu Ser Phe Ser 290 295 300 Gly Asn Leu Val Cys Glu Leu Phe Met Thr Ile Phe Asn Ile His Phe 305 310 315 320 Phe Thr Gln Val Gln Thr Lys Val Glu Ser Glu Phe Leu Gly Arg Val 325 330 335 Leu Ser Thr Ile Phe Thr Leu Ala Ile Leu Phe Met Pro Ile Ala Lys 340 345 350 Gly Phe Met Thr Val Leu Pro Ser Val His Leu Tyr Ser Phe Leu Ile 355 360 365 Ile Gly Leu Gly Val Val Ala Leu Tyr Phe Leu Ala Leu Gly Tyr Val 370 375 380 Arg Thr His Phe Glu Lys Leu Ile 385 390 121 2466 DNA Streptococcus pneumoniae 121 atgcaaaatc aattaaatga attaaaacga aaaatgctgg aatttttcca gcaaaaacaa 60 aaaaataaaa aatcagctag acctggcaag aaaggttcaa gtaccaaaaa atctaaaacc 120 ttagataagt cagccatttt cccagctatt ttactgagta taaaagcctt atttaactta 180 ctctttgtac tcggttttct aggaggaatg ttgggagctg ggattgcttt gggatacgga 240 gtggccttat ttgacaaggt tcgggtgcct cagacagaag aattggtgaa tcaggtcaag 300 gacatctctt ctatttcaga gattacctat tcggacggga cggtgattgc ttccatagag 360 agtgatttgt tgcgcacttc tatctcatct gagcaaattt cggaaaatct gaagaaggct 420 atcattgcga cagaagatga acactttaaa gaacataagg gtgtagtacc caaggcggtg 480 attcgtgcga ccttggggaa atttgtaggt ttgggttcct ctagtggggg ttcaaccttg 540 acccagcaac taattaaaca gcaggtggtt ggggatgcgc cgaccttggc tcgtaaggcg 600 gcagagattg tggatgctct tgccttggaa cgcgccatga ataaagatga gattttaacg 660 acctatctca atgtggctcc ctttggccga aataataagg gacagaatat tgcaggggct 720 cggcaagcag ctgagggaat tttcggtgta gatgccagtc agttgactgt tcctcaagca 780 gcatttttag caggacttcc acagagtccc attacttact ctccttatga aaatactggg 840 gagttgaaga gtgatgaaga cctagaaatt ggcttaagac gggctaaggc agttctttac 900 agtatgtatc gtacaggtgc attaagcaaa gacgagtatt ctcagtacaa ggattatgac 960 cttaaacagg actttttacc atcgggcacg gttacaggaa tttcacgaga ctatttatac 1020 tttacaactt tggcagaagc tcaagaacgt atgtatgact atctagctca gagagacaat 1080 gtctccgcta aggagttgaa aaatgaggca actcagaagt tttatcgaga tttggcagcc 1140 aaggaaattg aaaatggtgg ttataagatt actactacca tagatcagaa aattcattct 1200 gccatgcaaa gtgcggttgc tgattatggc tatcttttag acgatggaac aggtcgtgta 1260 gaagtaggga atgtcttgat ggataaccaa acaggtgcta ttctaggctt tgtaggtggt 1320 cgtaattatc aagaaaatca aaataatcat gcctttgata ccaaacgttc gccagcttct 1380 actaccaagc ccttgctggc ctacggtatt gctattgacc agggcttgat gggaagtgaa 1440 acgattctat ctaactatcc aacaaacttt gctaatggca atccgattat gtatgctaat 1500 agcaagggaa caggaatgat gaccttggga gaagctctga actattcatg gaatatccct 1560 gcttactgga cctatcgtat gctccgtgaa aagggtgttg atgtcaaggg ttatatggaa 1620 aagatgggtt acgagattcc tgagtacggt attgagagct tgccaatggg tggtggtatt 1680 gaagtcacag ttgcccagca taccaatggc tatcagacct tagctaataa tggagtttat 1740 catcagaagc atgtgatttc aaagattgaa gcagcagatg gtagagtggt gtatgagtat 1800 caggataaac cggttcaagt ctattcaaaa gctactgcga cgattatgca gggattgcta 1860 cgagaagttc tatcctctcg tgtgacaaca accttcaagt ctaacctgac ttctttaaat 1920 cctactctgg ctaatgcaga ttggattggg aagactggta caaccaacca agacgaaaat 1980 atgtggctca tgctttcgac acctagatta accctaggtg gctggattgg gcatgatgat 2040 aatcattcat tgtcacgtag agcaggttat tctaataact ctaattacat ggctcatctg 2100 gtaaatgcga ttcagcaagc ttccccaagc atttggggga acgagcgctt tgctttagat 2160 cctagtgtag tgaaatcgga agtcttgaaa tcaacaggtc aaaaaccaga gaaggtttct 2220 gttgaaggaa aagaagtaga ggtcacaggt tcgactgtta ccagctattg ggctaataag 2280 tcaggagcgc cagcgacaag ttatcgcttt gctattggcg gaagtgatgc ggattatcag 2340 aatgcttggt ctagtattgt ggggagtcta ccaactccat ccagctccag cagttcaagt 2400 agtagttcta gcgatagcag taactcaagt actacacgac cttcttcttc aagggcgaga 2460 cgataa 2466 122 821 PRT Streptococcus pneumoniae 122 Met Gln Asn Gln Leu Asn Glu Leu Lys Arg Lys Met Leu Glu Phe Phe 1 5 10 15 Gln Gln Lys Gln Lys Asn Lys Lys Ser Ala Arg Pro Gly Lys Lys Gly 20 25 30 Ser Ser Thr Lys Lys Ser Lys Thr Leu Asp Lys Ser Ala Ile Phe Pro 35 40 45 Ala Ile Leu Leu Ser Ile Lys Ala Leu Phe Asn Leu Leu Phe Val Leu 50 55 60 Gly Phe Leu Gly Gly Met Leu Gly Ala Gly Ile Ala Leu Gly Tyr Gly 65 70 75 80 Val Ala Leu Phe Asp Lys Val Arg Val Pro Gln Thr Glu Glu Leu Val 85 90 95 Asn Gln Val Lys Asp Ile Ser Ser Ile Ser Glu Ile Thr Tyr Ser Asp 100 105 110 Gly Thr Val Ile Ala Ser Ile Glu Ser Asp Leu Leu Arg Thr Ser Ile 115 120 125 Ser Ser Glu Gln Ile Ser Glu Asn Leu Lys Lys Ala Ile Ile Ala Thr 130 135 140 Glu Asp Glu His Phe Lys Glu His Lys Gly Val Val Pro Lys Ala Val 145 150 155 160 Ile Arg Ala Thr Leu Gly Lys Phe Val Gly Leu Gly Ser Ser Ser Gly 165 170 175 Gly Ser Thr Leu Thr Gln Gln Leu Ile Lys Gln Gln Val Val Gly Asp 180 185 190 Ala Pro Thr Leu Ala Arg Lys Ala Ala Glu Ile Val Asp Ala Leu Ala 195 200 205 Leu Glu Arg Ala Met Asn Lys Asp Glu Ile Leu Thr Thr Tyr Leu Asn 210 215 220 Val Ala Pro Phe Gly Arg Asn Asn Lys Gly Gln Asn Ile Ala Gly Ala 225 230 235 240 Arg Gln Ala Ala Glu Gly Ile Phe Gly Val Asp Ala Ser Gln Leu Thr 245 250 255 Val Pro Gln Ala Ala Phe Leu Ala Gly Leu Pro Gln Ser Pro Ile Thr 260 265 270 Tyr Ser Pro Tyr Glu Asn Thr Gly Glu Leu Lys Ser Asp Glu Asp Leu 275 280 285 Glu Ile Gly Leu Arg Arg Ala Lys Ala Val Leu Tyr Ser Met Tyr Arg 290 295 300 Thr Gly Ala Leu Ser Lys Asp Glu Tyr Ser Gln Tyr Lys Asp Tyr Asp 305 310 315 320 Leu Lys Gln Asp Phe Leu Pro Ser Gly Thr Val Thr Gly Ile Ser Arg 325 330 335 Asp Tyr Leu Tyr Phe Thr Thr Leu Ala Glu Ala Gln Glu Arg Met Tyr 340 345 350 Asp Tyr Leu Ala Gln Arg Asp Asn Val Ser Ala Lys Glu Leu Lys Asn 355 360 365 Glu Ala Thr Gln Lys Phe Tyr Arg Asp Leu Ala Ala Lys Glu Ile Glu 370 375 380 Asn Gly Gly Tyr Lys Ile Thr Thr Thr Ile Asp Gln Lys Ile His Ser 385 390 395 400 Ala Met Gln Ser Ala Val Ala Asp Tyr Gly Tyr Leu Leu Asp Asp Gly 405 410 415 Thr Gly Arg Val Glu Val Gly Asn Val Leu Met Asp Asn Gln Thr Gly 420 425 430 Ala Ile Leu Gly Phe Val Gly Gly Arg Asn Tyr Gln Glu Asn Gln Asn 435 440 445 Asn His Ala Phe Asp Thr Lys Arg Ser Pro Ala Ser Thr Thr Lys Pro 450 455 460 Leu Leu Ala Tyr Gly Ile Ala Ile Asp Gln Gly Leu Met Gly Ser Glu 465 470 475 480 Thr Ile Leu Ser Asn Tyr Pro Thr Asn Phe Ala Asn Gly Asn Pro Ile 485 490 495 Met Tyr Ala Asn Ser Lys Gly Thr Gly Met Met Thr Leu Gly Glu Ala 500 505 510 Leu Asn Tyr Ser Trp Asn Ile Pro Ala Tyr Trp Thr Tyr Arg Met Leu 515 520 525 Arg Glu Lys Gly Val Asp Val Lys Gly Tyr Met Glu Lys Met Gly Tyr 530 535 540 Glu Ile Pro Glu Tyr Gly Ile Glu Ser Leu Pro Met Gly Gly Gly Ile 545 550 555 560 Glu Val Thr Val Ala Gln His Thr Asn Gly Tyr Gln Thr Leu Ala Asn 565 570 575 Asn Gly Val Tyr His Gln Lys His Val Ile Ser Lys Ile Glu Ala Ala 580 585 590 Asp Gly Arg Val Val Tyr Glu Tyr Gln Asp Lys Pro Val Gln Val Tyr 595 600 605 Ser Lys Ala Thr Ala Thr Ile Met Gln Gly Leu Leu Arg Glu Val Leu 610 615 620 Ser Ser Arg Val Thr Thr Thr Phe Lys Ser Asn Leu Thr Ser Leu Asn 625 630 635 640 Pro Thr Leu Ala Asn Ala Asp Trp Ile Gly Lys Thr Gly Thr Thr Asn 645 650 655 Gln Asp Glu Asn Met Trp Leu Met Leu Ser Thr Pro Arg Leu Thr Leu 660 665 670 Gly Gly Trp Ile Gly His Asp Asp Asn His Ser Leu Ser Arg Arg Ala 675 680 685 Gly Tyr Ser Asn Asn Ser Asn Tyr Met Ala His Leu Val Asn Ala Ile 690 695 700 Gln Gln Ala Ser Pro Ser Ile Trp Gly Asn Glu Arg Phe Ala Leu Asp 705 710 715 720 Pro Ser Val Val Lys Ser Glu Val Leu Lys Ser Thr Gly Gln Lys Pro 725 730 735 Glu Lys Val Ser Val Glu Gly Lys Glu Val Glu Val Thr Gly Ser Thr 740 745 750 Val Thr Ser Tyr Trp Ala Asn Lys Ser Gly Ala Pro Ala Thr Ser Tyr 755 760 765 Arg Phe Ala Ile Gly Gly Ser Asp Ala Asp Tyr Gln Asn Ala Trp Ser 770 775 780 Ser Ile Val Gly Ser Leu Pro Thr Pro Ser Ser Ser Ser Ser Ser Ser 785 790 795 800 Ser Ser Ser Ser Asp Ser Ser Asn Ser Ser Thr Thr Arg Pro Ser Ser 805 810 815 Ser Arg Ala Arg Arg 820 123 1974 DNA Streptococcus pneumoniae 123 atgaaaaaat tttatgtaag tccaattttt cctattctag taggattgat tgcgtttgga 60 gtcttatcca ctttcattat ttttgttaat aataatctgt tgacggtttt aattttgttt 120 ctttttgtag gaggctatgt ttttttattt aagaaactga gagtgcatta tacaaggagt 180 gatgtagaac agatacagta tgtaaaccac caagcggaag aaagtttgac agctctattg 240 gaacagatgc ctgtaggtgt tatgaaattg aatttatctt ctggagaggt tgagtggttt 300 aatccctatg ctgaattgat tttgaccaag gaagatggtg attttgattt agaagctgtt 360 caaacgatta tcaaggcttc agtaggaaat ccgtctactt atgccaagct tggtgagaag 420 cgttatgctg ttcatatgga tgcttcttcc ggtgttttgt attttgtaga tgtatccagg 480 gaacaagcca taacagatga attggtaaca agtagaccag tgattgggat tgtctctgtg 540 gataattatg atgatttgga ggatgaaact tctgagtcag atattagtca aatcaatagt 600 tttgtagcta attttatatc agagttttca gaaaaacaca tgatgttttc tcgtcgggta 660 agtatggatc gattttatct atttactgac tacacggtgc ttgagggctt gatgaatgat 720 aaattttctg ttattgatgc tttcagagaa gagtcgaaac agagacagtt gcccttgacc 780 ttaagtatgg gattttctta tggcgatgga aatcatgatg agatagggaa agttgctttg 840 ctcaatttga acttggctga agtacgtggt ggcgaccagg tggttgttaa ggaaaacgac 900 gaaacgaaaa atccagttta ttttggtggt gggtctgctg cttcaatcaa gcgtacacgg 960 actcgtacgc gcgctatgat gacagctatt tcagataaga ttcggagtgt agatcaggtt 1020 tttgtagtcg gtcacaaaaa tttagacatg gatgctttgg gctctgctgt aggtatgcag 1080 ttgttcgcca gcaatgtgat tgaaaatagc tatgctcttt atgatgaaga acaaatgtct 1140 ccagatattg aacgagctgt ttcattcata gaaaaagaag gagttacgaa gttgttgtct 1200 gttaaggatg caatggggat ggtgaccaat cgttctttgt tgattcttgt agaccattca 1260 aagacagcct taacattatc aaaagaattt tatgatttat ttacccaaac cattgttatt 1320 gaccaccata gaagggatca ggattttcca gataatgcgg ttattactta tatcgaaagt 1380 ggtgcaagta gtgccagtga gttggtaacg gaattgattc agttccagaa ttctaagaaa 1440 aatcgtttga gtcgtatgca agcaagtgtc ttgatggctg gtatgatgtt ggatactaaa 1500 aatttcacct cgcgagtaac tagtcggaca tttgatgttg ctagctatct cagaacgcgc 1560 ggaagtgata gtattgctat ccaggaaatc gctgcgacag attttgaaga atatcgtgag 1620 gtcaatgaac ttattttaca ggggcgtaaa ttaggttcag atgtactaat agcagaggct 1680 aaggacatga aatgctatga tacagttgtt attagtaagg cagcagatgc catgttagcc 1740 atgtcaggta ttgaagcgag ttttgttctt gcgaagaata cacaaggatt tatctctatc 1800 tcagctcgaa gtcgtagtaa actgaatgta caacggatta tggaagagtt aggcggtgga 1860 ggccacttta atttggcagc agctcaaatt aaagatgtaa ccttgtcaga agcaggtgaa 1920 aaactgacag aaattgtatt aaatgaaatg aaggaaaagg agaaagaaga atga 1974 124 657 PRT Streptococcus pneumoniae 124 Met Lys Lys Phe Tyr Val Ser Pro Ile Phe Pro Ile Leu Val Gly Leu 1 5 10 15 Ile Ala Phe Gly Val Leu Ser Thr Phe Ile Ile Phe Val Asn Asn Asn 20 25 30 Leu Leu Thr Val Leu Ile Leu Phe Leu Phe Val Gly Gly Tyr Val Phe 35 40 45 Leu Phe Lys Lys Leu Arg Val His Tyr Thr Arg Ser Asp Val Glu Gln 50 55 60 Ile Gln Tyr Val Asn His Gln Ala Glu Glu Ser Leu Thr Ala Leu Leu 65 70 75 80 Glu Gln Met Pro Val Gly Val Met Lys Leu Asn Leu Ser Ser Gly Glu 85 90 95 Val Glu Trp Phe Asn Pro Tyr Ala Glu Leu Ile Leu Thr Lys Glu Asp 100 105 110 Gly Asp Phe Asp Leu Glu Ala Val Gln Thr Ile Ile Lys Ala Ser Val 115 120 125 Gly Asn Pro Ser Thr Tyr Ala Lys Leu Gly Glu Lys Arg Tyr Ala Val 130 135 140 His Met Asp Ala Ser Ser Gly Val Leu Tyr Phe Val Asp Val Ser Arg 145 150 155 160 Glu Gln Ala Ile Thr Asp Glu Leu Val Thr Ser Arg Pro Val Ile Gly 165 170 175 Ile Val Ser Val Asp Asn Tyr Asp Asp Leu Glu Asp Glu Thr Ser Glu 180 185 190 Ser Asp Ile Ser Gln Ile Asn Ser Phe Val Ala Asn Phe Ile Ser Glu 195 200 205 Phe Ser Glu Lys His Met Met Phe Ser Arg Arg Val Ser Met Asp Arg 210 215 220 Phe Tyr Leu Phe Thr Asp Tyr Thr Val Leu Glu Gly Leu Met Asn Asp 225 230 235 240 Lys Phe Ser Val Ile Asp Ala Phe Arg Glu Glu Ser Lys Gln Arg Gln 245 250 255 Leu Pro Leu Thr Leu Ser Met Gly Phe Ser Tyr Gly Asp Gly Asn His 260 265 270 Asp Glu Ile Gly Lys Val Ala Leu Leu Asn Leu Asn Leu Ala Glu Val 275 280 285 Arg Gly Gly Asp Gln Val Val Val Lys Glu Asn Asp Glu Thr Lys Asn 290 295 300 Pro Val Tyr Phe Gly Gly Gly Ser Ala Ala Ser Ile Lys Arg Thr Arg 305 310 315 320 Thr Arg Thr Arg Ala Met Met Thr Ala Ile Ser Asp Lys Ile Arg Ser 325 330 335 Val Asp Gln Val Phe Val Val Gly His Lys Asn Leu Asp Met Asp Ala 340 345 350 Leu Gly Ser Ala Val Gly Met Gln Leu Phe Ala Ser Asn Val Ile Glu 355 360 365 Asn Ser Tyr Ala Leu Tyr Asp Glu Glu Gln Met Ser Pro Asp Ile Glu 370 375 380 Arg Ala Val Ser Phe Ile Glu Lys Glu Gly Val Thr Lys Leu Leu Ser 385 390 395 400 Val Lys Asp Ala Met Gly Met Val Thr Asn Arg Ser Leu Leu Ile Leu 405 410 415 Val Asp His Ser Lys Thr Ala Leu Thr Leu Ser Lys Glu Phe Tyr Asp 420 425 430 Leu Phe Thr Gln Thr Ile Val Ile Asp His His Arg Arg Asp Gln Asp 435 440 445 Phe Pro Asp Asn Ala Val Ile Thr Tyr Ile Glu Ser Gly Ala Ser Ser 450 455 460 Ala Ser Glu Leu Val Thr Glu Leu Ile Gln Phe Gln Asn Ser Lys Lys 465 470 475 480 Asn Arg Leu Ser Arg Met Gln Ala Ser Val Leu Met Ala Gly Met Met 485 490 495 Leu Asp Thr Lys Asn Phe Thr Ser Arg Val Thr Ser Arg Thr Phe Asp 500 505 510 Val Ala Ser Tyr Leu Arg Thr Arg Gly Ser Asp Ser Ile Ala Ile Gln 515 520 525 Glu Ile Ala Ala Thr Asp Phe Glu Glu Tyr Arg Glu Val Asn Glu Leu 530 535 540 Ile Leu Gln Gly Arg Lys Leu Gly Ser Asp Val Leu Ile Ala Glu Ala 545 550 555 560 Lys Asp Met Lys Cys Tyr Asp Thr Val Val Ile Ser Lys Ala Ala Asp 565 570 575 Ala Met Leu Ala Met Ser Gly Ile Glu Ala Ser Phe Val Leu Ala Lys 580 585 590 Asn Thr Gln Gly Phe Ile Ser Ile Ser Ala Arg Ser Arg Ser Lys Leu 595 600 605 Asn Val Gln Arg Ile Met Glu Glu Leu Gly Gly Gly Gly His Phe Asn 610 615 620 Leu Ala Ala Ala Gln Ile Lys Asp Val Thr Leu Ser Glu Ala Gly Glu 625 630 635 640 Lys Leu Thr Glu Ile Val Leu Asn Glu Met Lys Glu Lys Glu Lys Glu 645 650 655 Glu 125 663 DNA Streptococcus pneumoniae 125 atgaagtgct tgttatgtgg gcagactatg aagactgttt taacttttag tagtctctta 60 cttctgagga atgatgactc ttgtctttgt tcagactgtg attctacttt tgaaagaatt 120 ggggaagaga actgtccaaa ttgtatgaaa acagagttgt caacaaagtg tcaagattgt 180 caactttggt gtaaagaggg agttgaagtc agtcatagag cgatttttac ttacaatcaa 240 gctatgaagg attttttcag tcggtataag tttgatggag acttcctgtt aagaaaagtt 300 ttcgcttcat ttttaagtga ggagttgaaa aagtacaaag agtatcaatt tgttgtaatt 360 cccctaagtc ctgatagata tgctaataga ggatttaatc aggttgaggg cttggtagag 420 gcagcaggct ttgagtatct ggatttatta gagaaaagag aagagagagc cagttcttct 480 aaaaatcgtt cagagcgctt ggggacagaa cttcctttct ttattaaaag tggagtcact 540 attcctaaaa aaatcctact tatagatgat atctatacta caggagcaac tataaatcgt 600 gttaagaaac tgttggaaga agctggtgct aaggatgtaa aaacattttc ccttgtaaga 660 tga 663 126 220 PRT Streptococcus pneumoniae 126 Met Lys Cys Leu Leu Cys Gly Gln Thr Met Lys Thr Val Leu Thr Phe 1 5 10 15 Ser Ser Leu Leu Leu Leu Arg Asn Asp Asp Ser Cys Leu Cys Ser Asp 20 25 30 Cys Asp Ser Thr Phe Glu Arg Ile Gly Glu Glu Asn Cys Pro Asn Cys 35 40 45 Met Lys Thr Glu Leu Ser Thr Lys Cys Gln Asp Cys Gln Leu Trp Cys 50 55 60 Lys Glu Gly Val Glu Val Ser His Arg Ala Ile Phe Thr Tyr Asn Gln 65 70 75 80 Ala Met Lys Asp Phe Phe Ser Arg Tyr Lys Phe Asp Gly Asp Phe Leu 85 90 95 Leu Arg Lys Val Phe Ala Ser Phe Leu Ser Glu Glu Leu Lys Lys Tyr 100 105 110 Lys Glu Tyr Gln Phe Val Val Ile Pro Leu Ser Pro Asp Arg Tyr Ala 115 120 125 Asn Arg Gly Phe Asn Gln Val Glu Gly Leu Val Glu Ala Ala Gly Phe 130 135 140 Glu Tyr Leu Asp Leu Leu Glu Lys Arg Glu Glu Arg Ala Ser Ser Ser 145 150 155 160 Lys Asn Arg Ser Glu Arg Leu Gly Thr Glu Leu Pro Phe Phe Ile Lys 165 170 175 Ser Gly Val Thr Ile Pro Lys Lys Ile Leu Leu Ile Asp Asp Ile Tyr 180 185 190 Thr Thr Gly Ala Thr Ile Asn Arg Val Lys Lys Leu Leu Glu Glu Ala 195 200 205 Gly Ala Lys Asp Val Lys Thr Phe Ser Leu Val Arg 210 215 220 127 1299 DNA Streptococcus pneumoniae 127 atgaaagtaa atttagatta tctcggtcgt ttatttactg agaatgaatt aacagaagaa 60 gaacgtcagt tggcggagaa acttccagca atgagaaagg agaaggggaa acttttctgt 120 caacgctgta atagtactat tctagaagaa tggtatttgc ccatcggtgc ttactattgt 180 cgagagtgct tgctgatgaa gcgagtcaga agtgatcaaa ctttatacta ttttccgcag 240 gaggattttc caaagcaaga tgttctcaaa tggcgcggcc aattaactcc ttttcaagag 300 aaggtgtcag agggattgct tcaagtagta gacaagcaaa agccaacctt agttcatgcg 360 gtaacaggag ctggaaagac agaaatgatt tatcaagtag tggctaaagt gatcaatgcg 420 ggtggtgcag tgtgtttggc tagtcctcgc atagatgttt gtttggagct gtacaagcgc 480 ctgcaacagg atttttcttg cgggatagct ttgctacatg gagaatcgga accttatttt 540 cgaacaccac tagttgttgc aacaacccat cagttattga agttttatca agcttttgat 600 ttgctgatag tggatgaagt agatgctttt ccttatgttg ataatcccat gctttaccac 660 gctgtcaaga atagtgtaaa ggagaatgga ttgagaatct ttttaacagc gacttcgacc 720 aatgagttag ataaaaaggt ccgtttagga gaactaaaaa gactgaattt accgagacgg 780 tttcatggaa atccgttgat tattccaaaa ccaatttggt tatcggattt taatcgctac 840 ttagacaaga atcgtttgtc accaaagtta aagtcctata ttgagaagca gagaaagaca 900 gcttatccgt tactcatttt tgcttcagaa attaagaaag gggagcagtt agcagaaatc 960 ttacaggagc aatttccaaa tgagaaaatt ggctttgtat cttctgtaac agaggatcga 1020 ttagagcaag tacaagcttt tcgagatgga gaactgacaa tacttatcag tacgacaatc 1080 ttggagcgcg gagttacctt cccttgtgtg gatgttttcg tagtagaggc caatcatcgt 1140 ttgtttacca agtctagttt gattcagatt ggtggacgag ttggacgaag catggataga 1200 ccgacaggag atttgctttt cttccatgat gggttaaatg cttcaatcaa gaaggcgatt 1260 aaggaaattc agatgatgaa taaggaggct ggtctatga 1299 128 432 PRT Streptococcus pneumoniae 128 Met Lys Val Asn Leu Asp Tyr Leu Gly Arg Leu Phe Thr Glu Asn Glu 1 5 10 15 Leu Thr Glu Glu Glu Arg Gln Leu Ala Glu Lys Leu Pro Ala Met Arg 20 25 30 Lys Glu Lys Gly Lys Leu Phe Cys Gln Arg Cys Asn Ser Thr Ile Leu 35 40 45 Glu Glu Trp Tyr Leu Pro Ile Gly Ala Tyr Tyr Cys Arg Glu Cys Leu 50 55 60 Leu Met Lys Arg Val Arg Ser Asp Gln Thr Leu Tyr Tyr Phe Pro Gln 65 70 75 80 Glu Asp Phe Pro Lys Gln Asp Val Leu Lys Trp Arg Gly Gln Leu Thr 85 90 95 Pro Phe Gln Glu Lys Val Ser Glu Gly Leu Leu Gln Val Val Asp Lys 100 105 110 Gln Lys Pro Thr Leu Val His Ala Val Thr Gly Ala Gly Lys Thr Glu 115 120 125 Met Ile Tyr Gln Val Val Ala Lys Val Ile Asn Ala Gly Gly Ala Val 130 135 140 Cys Leu Ala Ser Pro Arg Ile Asp Val Cys Leu Glu Leu Tyr Lys Arg 145 150 155 160 Leu Gln Gln Asp Phe Ser Cys Gly Ile Ala Leu Leu His Gly Glu Ser 165 170 175 Glu Pro Tyr Phe Arg Thr Pro Leu Val Val Ala Thr Thr His Gln Leu 180 185 190 Leu Lys Phe Tyr Gln Ala Phe Asp Leu Leu Ile Val Asp Glu Val Asp 195 200 205 Ala Phe Pro Tyr Val Asp Asn Pro Met Leu Tyr His Ala Val Lys Asn 210 215 220 Ser Val Lys Glu Asn Gly Leu Arg Ile Phe Leu Thr Ala Thr Ser Thr 225 230 235 240 Asn Glu Leu Asp Lys Lys Val Arg Leu Gly Glu Leu Lys Arg Leu Asn 245 250 255 Leu Pro Arg Arg Phe His Gly Asn Pro Leu Ile Ile Pro Lys Pro Ile 260 265 270 Trp Leu Ser Asp Phe Asn Arg Tyr Leu Asp Lys Asn Arg Leu Ser Pro 275 280 285 Lys Leu Lys Ser Tyr Ile Glu Lys Gln Arg Lys Thr Ala Tyr Pro Leu 290 295 300 Leu Ile Phe Ala Ser Glu Ile Lys Lys Gly Glu Gln Leu Ala Glu Ile 305 310 315 320 Leu Gln Glu Gln Phe Pro Asn Glu Lys Ile Gly Phe Val Ser Ser Val 325 330 335 Thr Glu Asp Arg Leu Glu Gln Val Gln Ala Phe Arg Asp Gly Glu Leu 340 345 350 Thr Ile Leu Ile Ser Thr Thr Ile Leu Glu Arg Gly Val Thr Phe Pro 355 360 365 Cys Val Asp Val Phe Val Val Glu Ala Asn His Arg Leu Phe Thr Lys 370 375 380 Ser Ser Leu Ile Gln Ile Gly Gly Arg Val Gly Arg Ser Met Asp Arg 385 390 395 400 Pro Thr Gly Asp Leu Leu Phe Phe His Asp Gly Leu Asn Ala Ser Ile 405 410 415 Lys Lys Ala Ile Lys Glu Ile Gln Met Met Asn Lys Glu Ala Gly Leu 420 425 430 129 870 DNA Streptococcus pneumoniae 129 atgcaaattc aaaaaagttt taaggggcag tctccctatg gcaagctgta tctagtggca 60 acgccgattg gcaatctaga tgatatgact tttcgtgcta tccagacctt gaaagaagtg 120 gactggattg ctgctgagga tacgcgcaat acagggcttt tgctcaagca ttttgacatt 180 tccaccaagc agatcagttt tcatgagcac aatgccaagg aaaaaattcc tgatttgatt 240 ggtttcttga aagcagggca aagtattgct caggtctctg atgccggttt gcctagcatt 300 tcagaccctg gtcatgattt agttaaggca gctattgagg aagaaattgc agttgtgaca 360 gttccaggtg cctctgcagg aatttctgcc ttgattgcca gtggtttagc gccacagcca 420 catatctttt acggtttttt accgagaaaa tcaggtcagc agaagcaatt ttttggcttg 480 aaaaaagatt atcctgaaac acagattttt tatgaatcac ctcatcgtgt agcagacacg 540 ttggaaaata tgttagaagt ctacggtgac cgctccgttg tcttggtcag ggaattgacc 600 aaaatctatg aagaatacca acgaggtact atctctgagt tattagaaag cattgctgaa 660 acgccactca agggcgaatg tcttctcatt gttgagggtg ccagtcaggg tgtggaggaa 720 aaggacgagg aagacttgtt cgtagaaatt caaacccgca tccagcaagg tgtgaagaaa 780 aaccaagcta tcaaggaagt cgctaagatt taccagtgga ataaaagtca gctctacgct 840 gcctaccacg actgggaaga aaaacaataa 870 130 289 PRT Streptococcus pneumoniae 130 Met Gln Ile Gln Lys Ser Phe Lys Gly Gln Ser Pro Tyr Gly Lys Leu 1 5 10 15 Tyr Leu Val Ala Thr Pro Ile Gly Asn Leu Asp Asp Met Thr Phe Arg 20 25 30 Ala Ile Gln Thr Leu Lys Glu Val Asp Trp Ile Ala Ala Glu Asp Thr 35 40 45 Arg Asn Thr Gly Leu Leu Leu Lys His Phe Asp Ile Ser Thr Lys Gln 50 55 60 Ile Ser Phe His Glu His Asn Ala Lys Glu Lys Ile Pro Asp Leu Ile 65 70 75 80 Gly Phe Leu Lys Ala Gly Gln Ser Ile Ala Gln Val Ser Asp Ala Gly 85 90 95 Leu Pro Ser Ile Ser Asp Pro Gly His Asp Leu Val Lys Ala Ala Ile 100 105 110 Glu Glu Glu Ile Ala Val Val Thr Val Pro Gly Ala Ser Ala Gly Ile 115 120 125 Ser Ala Leu Ile Ala Ser Gly Leu Ala Pro Gln Pro His Ile Phe Tyr 130 135 140 Gly Phe Leu Pro Arg Lys Ser Gly Gln Gln Lys Gln Phe Phe Gly Leu 145 150 155 160 Lys Lys Asp Tyr Pro Glu Thr Gln Ile Phe Tyr Glu Ser Pro His Arg 165 170 175 Val Ala Asp Thr Leu Glu Asn Met Leu Glu Val Tyr Gly Asp Arg Ser 180 185 190 Val Val Leu Val Arg Glu Leu Thr Lys Ile Tyr Glu Glu Tyr Gln Arg 195 200 205 Gly Thr Ile Ser Glu Leu Leu Glu Ser Ile Ala Glu Thr Pro Leu Lys 210 215 220 Gly Glu Cys Leu Leu Ile Val Glu Gly Ala Ser Gln Gly Val Glu Glu 225 230 235 240 Lys Asp Glu Glu Asp Leu Phe Val Glu Ile Gln Thr Arg Ile Gln Gln 245 250 255 Gly Val Lys Lys Asn Gln Ala Ile Lys Glu Val Ala Lys Ile Tyr Gln 260 265 270 Trp Asn Lys Ser Gln Leu Tyr Ala Ala Tyr His Asp Trp Glu Glu Lys 275 280 285 Gln 131 345 DNA Streptococcus pneumoniae 131 atgataaaga aaggaaaggg ctgttttatg gacaaaaaag aattatttga cgcgctggat 60 gatttttccc aacaattatt ggtaacctta gccgatgtgg aagccatcaa gaaaaatctc 120 aagagcctgg tagaggaaaa tacagctctt cgcttggaaa atagtaagtt gcgagaacgc 180 ttgggtgagg tggaagcaga tgctcctgtc aaggccaagc atgttcgcga aagtgtccgt 240 cgtatttacc gtgatggatt tcacgtatgt aatgattttt atggacaacg tcgagagcag 300 gacgaagaat gtatgttttg tgacgagttg ttatacaggg agtaa 345 132 114 PRT Streptococcus pneumoniae 132 Met Ile Lys Lys Gly Lys Gly Cys Phe Met Asp Lys Lys Glu Leu Phe 1 5 10 15 Asp Ala Leu Asp Asp Phe Ser Gln Gln Leu Leu Val Thr Leu Ala Asp 20 25 30 Val Glu Ala Ile Lys Lys Asn Leu Lys Ser Leu Val Glu Glu Asn Thr 35 40 45 Ala Leu Arg Leu Glu Asn Ser Lys Leu Arg Glu Arg Leu Gly Glu Val 50 55 60 Glu Ala Asp Ala Pro Val Lys Ala Lys His Val Arg Glu Ser Val Arg 65 70 75 80 Arg Ile Tyr Arg Asp Gly Phe His Val Cys Asn Asp Phe Tyr Gly Gln 85 90 95 Arg Arg Glu Gln Asp Glu Glu Cys Met Phe Cys Asp Glu Leu Leu Tyr 100 105 110 Arg Glu 133 639 DNA Streptococcus pneumoniae 133 atgtcaaaag gatttttagt ctctcttgag ggaccagagg gagcaggcaa gaccagtgtt 60 ttagaggctc tgctaccaat tttagaggaa aaaggagtag aggtgttgac gacccgtgaa 120 cctggcggag tcttgattgg ggagaagatt cgggaagtga ttttggatcc aagtcatact 180 cagatggatg ctaaaacaga gctacttctc tatattgcca gtcgcagaca gcatttggtg 240 gaaaaagttc ttccagccct tgaagctggc aagttggtca tcatggatcg ttttatcgat 300 agttctgttg cctatcaggg atttggtcgt ggcttagata ttgaagccat tgactggctc 360 aatcagtttg cgacagatgg cctcaaaccc gatttgacac tctattttga catcgaggtg 420 gaagaagggc tggctcgtat tgctgctaat agtgaccgcg aggttaatcg tttggatttg 480 gaagggttgg acttgcataa aaaagttcgt caaggctacc tttctcttct ggataaagag 540 ggaaatcgca ttgtcaagat tgatgctagt ctccctttgg agcaagttgt ggaaactacc 600 aaggctgtct tgtttgacgg aatgggcttg gccaaatga 639 134 212 PRT Streptococcus pneumoniae 134 Met Ser Lys Gly Phe Leu Val Ser Leu Glu Gly Pro Glu Gly Ala Gly 1 5 10 15 Lys Thr Ser Val Leu Glu Ala Leu Leu Pro Ile Leu Glu Glu Lys Gly 20 25 30 Val Glu Val Leu Thr Thr Arg Glu Pro Gly Gly Val Leu Ile Gly Glu 35 40 45 Lys Ile Arg Glu Val Ile Leu Asp Pro Ser His Thr Gln Met Asp Ala 50 55 60 Lys Thr Glu Leu Leu Leu Tyr Ile Ala Ser Arg Arg Gln His Leu Val 65 70 75 80 Glu Lys Val Leu Pro Ala Leu Glu Ala Gly Lys Leu Val Ile Met Asp 85 90 95 Arg Phe Ile Asp Ser Ser Val Ala Tyr Gln Gly Phe Gly Arg Gly Leu 100 105 110 Asp Ile Glu Ala Ile Asp Trp Leu Asn Gln Phe Ala Thr Asp Gly Leu 115 120 125 Lys Pro Asp Leu Thr Leu Tyr Phe Asp Ile Glu Val Glu Glu Gly Leu 130 135 140 Ala Arg Ile Ala Ala Asn Ser Asp Arg Glu Val Asn Arg Leu Asp Leu 145 150 155 160 Glu Gly Leu Asp Leu His Lys Lys Val Arg Gln Gly Tyr Leu Ser Leu 165 170 175 Leu Asp Lys Glu Gly Asn Arg Ile Val Lys Ile Asp Ala Ser Leu Pro 180 185 190 Leu Glu Gln Val Val Glu Thr Thr Lys Ala Val Leu Phe Asp Gly Met 195 200 205 Gly Leu Ala Lys 210 135 474 DNA Streptococcus pneumoniae 135 atggtagaac aaagaaaatc aattaccatg aaagatgttg ctttagaagc aggagttagt 60 gttggaactg tttcacgtgt aattaataaa gaaaaaggca ttaaagaagt aactttgaaa 120 aaagtggaac aagcgattaa aactttgaat tacattccag attactacgc tagaggaatg 180 aaaaaaaatc gaacagaaac gattgcaatc attgtaccaa gtatctggca tcccttcttt 240 tcagaatttg ctatgcatgt ggaaaatgaa gtctataaga gaaataacaa attactctta 300 tgttctatca atggtacaaa tagagagcaa gactatctgg agatgttgcg tcataataaa 360 gttgatggag tggttgccat tacctatagg ccaattgaac attacttgac gtcaggaatt 420 ccctttgtta gtattgaccg cacatactca gagattgcca ttccttgtgt ttca 474 136 158 PRT Streptococcus pneumoniae 136 Met Val Glu Gln Arg Lys Ser Ile Thr Met Lys Asp Val Ala Leu Glu 1 5 10 15 Ala Gly Val Ser Val Gly Thr Val Ser Arg Val Ile Asn Lys Glu Lys 20 25 30 Gly Ile Lys Glu Val Thr Leu Lys Lys Val Glu Gln Ala Ile Lys Thr 35 40 45 Leu Asn Tyr Ile Pro Asp Tyr Tyr Ala Arg Gly Met Lys Lys Asn Arg 50 55 60 Thr Glu Thr Ile Ala Ile Ile Val Pro Ser Ile Trp His Pro Phe Phe 65 70 75 80 Ser Glu Phe Ala Met His Val Glu Asn Glu Val Tyr Lys Arg Asn Asn 85 90 95 Lys Leu Leu Leu Cys Ser Ile Asn Gly Thr Asn Arg Glu Gln Asp Tyr 100 105 110 Leu Glu Met Leu Arg His Asn Lys Val Asp Gly Val Val Ala Ile Thr 115 120 125 Tyr Arg Pro Ile Glu His Tyr Leu Thr Ser Gly Ile Pro Phe Val Ser 130 135 140 Ile Asp Arg Thr Tyr Ser Glu Ile Ala Ile Pro Cys Val Ser 145 150 155 137 374 DNA Streptococcus pneumoniae 137 atgaatatat ttagaacaaa gaatgttagt ttagataaaa cagagatgca taggcatttg 60 aagttatggg atttgatttt gctgggtatc ggagccatgg tagggacagg cgtctttaca 120 atcacaggta ctgcagctgc aacacttgct ggcccagccc tagtgatttc aatcgttatt 180 tctgccttgt gtgtgggatt atcagccctc ttttttgcag aatttgcctc gcgagtaccc 240 gctacaggag gtgcctatag ttacctctat gctatcttag gagaattccc tgcctggttg 300 gctggttggt taaccatgat ggagttcatg acagccatat caggcgtagc ttcgggttgg 360 gcagcttatt ttaa 374 138 124 PRT Streptococcus pneumoniae 138 Met Asn Ile Phe Arg Thr Lys Asn Val Ser Leu Asp Lys Thr Glu Met 1 5 10 15 His Arg His Leu Lys Leu Trp Asp Leu Ile Leu Leu Gly Ile Gly Ala 20 25 30 Met Val Gly Thr Gly Val Phe Thr Ile Thr Gly Thr Ala Ala Ala Thr 35 40 45 Leu Ala Gly Pro Ala Leu Val Ile Ser Ile Val Ile Ser Ala Leu Cys 50 55 60 Val Gly Leu Ser Ala Leu Phe Phe Ala Glu Phe Ala Ser Arg Val Pro 65 70 75 80 Ala Thr Gly Gly Ala Tyr Ser Tyr Leu Tyr Ala Ile Leu Gly Glu Phe 85 90 95 Pro Ala Trp Leu Ala Gly Trp Leu Thr Met Met Glu Phe Met Thr Ala 100 105 110 Ile Ser Gly Val Ala Ser Gly Trp Ala Ala Tyr Phe 115 120 139 1311 DNA Streptococcus pneumoniae 139 atgaaatcaa gagtaaagga aacgagtatg gataaaattg tggttcaagg tggcgataat 60 cgtctggtag gaagcgtgac gatcgaggga gcaaaaaatg cagtcttacc cttgttggca 120 gcgactattc tagcaagtga aggaaagacc gtcttgcaga atgttccgat tttgtcggat 180 gtctttatta tgaatcaggt agttggtggt ttgaatgcca aggttgactt tgatgaggaa 240 gctcatcttg tcaaggtgga tgctactggc gacatcactg aggaagcccc ttacaagtat 300 gtcagcaaga tgcgcgcctc catcgttgta ttagggccaa tccttgcccg tgtgggtcat 360 gccaaggtat ccatgccagg tggttgtacg attggtagcc gtcctattga tcttcatttg 420 aaaggtctgg aagctatggg ggttaagatt agtcagacag ctggttacat cgaagccaag 480 gcagaacgct tgcatggtgc tcatatctat atggactttc caagtgttgg tgcaacgcag 540 aacttgatga tggcagcgac tctggctgat ggggtgacag tgattgagaa tgctgcgcgt 600 gagcctgaga ttgttgactt agccattctc cttaatgaaa tgggagccaa ggtcaaaggt 660 gctggtacag agactataac cattactggt gttgagaaac ttcatggtac gactcacaat 720 gtagtccaag accgtatcga agcaggaacc tttatggtag ctgctgccat gactggtggt 780 gatgtcttga ttcgagacgc tgtctgggag cacaaccgtc ccttgattgc caagttactt 840 gaaatgggtg ttgaagtaat tgaagaagac gaaggaattc gtgttcgttc tcaactagaa 900 aatctaaaag ctgttcatgt gaaaaccttg ccccacccag gatttccaac agatatgcag 960 gctcaattta cagccttgat gacagttgca aaaggcgaat caaccatggt ggagacagtt 1020 ttcgaaaatc gtttccaaca cctagaagag atgcgccgca tgggcttgca ttctgagatt 1080 atccgtgata cagctcgtat tgttggtgga cagcctttgc agggagcaga agttctttca 1140 actgaccttc gtgccagtgc ggccttgatt ttgacaggtt tggtagcaca gggagaaact 1200 gtggtcggta aattggttca cttggataga ggttactacg gtttccatga gaagttggcg 1260 cagctaggtg ctaagattca gcggattgag gcaagtgatg aagatgaata a 1311 140 436 PRT Streptococcus pneumoniae 140 Met Lys Ser Arg Val Lys Glu Thr Ser Met Asp Lys Ile Val Val Gln 1 5 10 15 Gly Gly Asp Asn Arg Leu Val Gly Ser Val Thr Ile Glu Gly Ala Lys 20 25 30 Asn Ala Val Leu Pro Leu Leu Ala Ala Thr Ile Leu Ala Ser Glu Gly 35 40 45 Lys Thr Val Leu Gln Asn Val Pro Ile Leu Ser Asp Val Phe Ile Met 50 55 60 Asn Gln Val Val Gly Gly Leu Asn Ala Lys Val Asp Phe Asp Glu Glu 65 70 75 80 Ala His Leu Val Lys Val Asp Ala Thr Gly Asp Ile Thr Glu Glu Ala 85 90 95 Pro Tyr Lys Tyr Val Ser Lys Met Arg Ala Ser Ile Val Val Leu Gly 100 105 110 Pro Ile Leu Ala Arg Val Gly His Ala Lys Val Ser Met Pro Gly Gly 115 120 125 Cys Thr Ile Gly Ser Arg Pro Ile Asp Leu His Leu Lys Gly Leu Glu 130 135 140 Ala Met Gly Val Lys Ile Ser Gln Thr Ala Gly Tyr Ile Glu Ala Lys 145 150 155 160 Ala Glu Arg Leu His Gly Ala His Ile Tyr Met Asp Phe Pro Ser Val 165 170 175 Gly Ala Thr Gln Asn Leu Met Met Ala Ala Thr Leu Ala Asp Gly Val 180 185 190 Thr Val Ile Glu Asn Ala Ala Arg Glu Pro Glu Ile Val Asp Leu Ala 195 200 205 Ile Leu Leu Asn Glu Met Gly Ala Lys Val Lys Gly Ala Gly Thr Glu 210 215 220 Thr Ile Thr Ile Thr Gly Val Glu Lys Leu His Gly Thr Thr His Asn 225 230 235 240 Val Val Gln Asp Arg Ile Glu Ala Gly Thr Phe Met Val Ala Ala Ala 245 250 255 Met Thr Gly Gly Asp Val Leu Ile Arg Asp Ala Val Trp Glu His Asn 260 265 270 Arg Pro Leu Ile Ala Lys Leu Leu Glu Met Gly Val Glu Val Ile Glu 275 280 285 Glu Asp Glu Gly Ile Arg Val Arg Ser Gln Leu Glu Asn Leu Lys Ala 290 295 300 Val His Val Lys Thr Leu Pro His Pro Gly Phe Pro Thr Asp Met Gln 305 310 315 320 Ala Gln Phe Thr Ala Leu Met Thr Val Ala Lys Gly Glu Ser Thr Met 325 330 335 Val Glu Thr Val Phe Glu Asn Arg Phe Gln His Leu Glu Glu Met Arg 340 345 350 Arg Met Gly Leu His Ser Glu Ile Ile Arg Asp Thr Ala Arg Ile Val 355 360 365 Gly Gly Gln Pro Leu Gln Gly Ala Glu Val Leu Ser Thr Asp Leu Arg 370 375 380 Ala Ser Ala Ala Leu Ile Leu Thr Gly Leu Val Ala Gln Gly Glu Thr 385 390 395 400 Val Val Gly Lys Leu Val His Leu Asp Arg Gly Tyr Tyr Gly Phe His 405 410 415 Glu Lys Leu Ala Gln Leu Gly Ala Lys Ile Gln Arg Ile Glu Ala Ser 420 425 430 Asp Glu Asp Glu 435 141 1101 DNA Streptococcus pneumoniae 141 atgttattag cgtcaacagt agccttgtca tttgccccag tattggcaac tcaagcagaa 60 gaagttcttt ggactgcacg tagtgttgag caaatccaaa acgatttgac taaaacggac 120 aacaaaacaa gttataccgt acagtatggt gatactttga gcaccattgc agaagccttg 180 ggtgtagatg tcacagtgct tgcgaatctg aacaaaatca ctaatatgga cttgattttc 240 ccagaaactg ttttgacaac gactgtcaat gaagcagaag aagtaacaga agttgaaatc 300 caaacacctc aagcagactc tagtgaagaa gtgacaactg cgacagcaga tttgaccact 360 aatcaagtga ccgttgatga tcaaactgtt caggttgcag acctttctca accaattgca 420 gaagttacaa agacagtgat tgcttctgaa gaagtggcac catctacggg cacttctgtc 480 ccagaggagc aaacgaccga aacaactcgc ccagttgcag aagaagctcc tcaggaaacg 540 actccagctg agaagcagga aacacaaaca agccctcaag ctgcatcagc agtggaagca 600 actacaacaa gttcagaagc aaaagaagta gcatcatcaa atggagctac agcagcagtt 660 tctacttatc aaccagaaga aacgaaagta atttcaacaa cttacgaggc tccagctgcg 720 cccgattatg ctggacttgc agtagcaaaa tctgaaaatg caggtcttca accacaaaca 780 gctgccttta aagaagaaat tgctaacttg tttggcatta catcctttag tggttatcgt 840 ccaggagaca gtggagatca cggaaaaggt ttggctatcg actttatggt accagaacgt 900 tcagaattag gggataagat tgcggaatat gctattcaaa atatggccag ccgtggcatt 960 agttacatca tctggaaaca acgtttctat gctccattcg atagcaaata tgggccagct 1020 aacacttgga acccaatgcc agaccgtggt agtgtgacag aaaatcacta tgatcacgtt 1080 cacgtttcaa tgaatggata a 1101 142 302 PRT Streptococcus pneumoniae 142 Met Leu Leu Ala Ser Thr Val Ala Leu Ser Phe Ala Pro Val Leu Ala 1 5 10 15 Thr Gln Ala Glu Glu Val Leu Trp Thr Ala Arg Ser Val Glu Gln Ile 20 25 30 Gln Asn Asp Leu Thr Lys Thr Asp Asn Lys Thr Ser Tyr Thr Val Gln 35 40 45 Tyr Gly Asp Thr Leu Ser Thr Ile Ala Glu Ala Leu Gly Val Asp Val 50 55 60 Thr Val Leu Ala Asn Leu Asn Lys Ile Thr Asn Met Asp Leu Ile Phe 65 70 75 80 Pro Glu Thr Val Leu Thr Thr Thr Val Asn Glu Ala Glu Glu Val Thr 85 90 95 Glu Val Glu Ile Gln Thr Pro Gln Ala Asp Ser Ser Glu Glu Val Thr 100 105 110 Thr Ala Thr Ala Asp Leu Thr Thr Asn Gln Val Thr Val Asp Asp Gln 115 120 125 Thr Val Gln Val Ala Asp Leu Ser Gln Pro Ile Ala Glu Val Thr Lys 130 135 140 Thr Val Ile Ala Ser Glu Glu Val Ala Pro Ser Thr Gly Thr Ser Val 145 150 155 160 Pro Glu Glu Gln Thr Thr Glu Thr Thr Arg Pro Val Ala Glu Glu Ala 165 170 175 Pro Gln Glu Thr Thr Pro Ala Glu Lys Gln Glu Thr Gln Thr Ser Pro 180 185 190 Gln Ala Ala Ser Ala Val Glu Ala Thr Thr Thr Ser Ser Glu Ala Lys 195 200 205 Glu Val Ala Ser Ser Asn Gly Ala Thr Ala Ala Val Ser Thr Tyr Gln 210 215 220 Pro Glu Glu Thr Lys Val Ile Ser Thr Thr Tyr Glu Ala Pro Ala Ala 225 230 235 240 Pro Asp Tyr Ala Gly Leu Ala Val Ala Lys Ser Glu Asn Ala Gly Leu 245 250 255 Gln Pro Gln Thr Ala Ala Phe Lys Lys Lys Leu Leu Thr Cys Leu Ala 260 265 270 Leu His Pro Leu Val Val Ile Val Gln Glu Thr Val Glu Ile Thr Glu 275 280 285 Lys Val Trp Leu Ser Thr Leu Trp Tyr Gln Asn Val Gln Asn 290 295 300 143 1281 DNA Streptococcus pneumoniae 143 ttgtttaaga aaaataaaga cattcttaat attgcattgc cagctatggg tgaaaacttt 60 ttgcagatgc taatgggaat ggtggacagt tatttggttg ctcatttagg attgatagct 120 atttcagggg tttcagtagc tggtaatatt atcaccattt atcaggcgat tttcatcgct 180 ctgggagctg ctatttccag tgttatttca aaaagcatag ggcagaaaga ccagtcgaag 240 ttggcctatc atgtgactga ggcgttgaag attaccttac tattaagttt ccttttagga 300 tttttgtcca tcttcgctgg gaaagagatg ataggacttt tggggacgga gagggatgta 360 gctgagagtg gtggactgta tctatctttg gtaggcggat cgattgttct cttaggttta 420 atgactagtc taggagcctt gattcgtgca acgcataatc cacgtctgcc tctctatgtt 480 agttttttat ccaatgcctt gaatattctt ttttcaagtc tagctatttt tgttctggat 540 atggggatag ctggtgttgc ttgggggaca attgtgtctc gtttggttgg tcttgtgatt 600 ttgtggtcac aattaaaact gccttatggg aagccaactt ttggtttaga taaggaactg 660 ttgaccttgg ctttaccagc agctggagag cgacttatga tgagggctgg agatgtagtg 720 atcattgcct tggtcgtttc ttttgggacg gaggcagttg ctgggaatgc aatcggagaa 780 gtcttgaccc agtttaacta tatgcctgcc tttggcgtcg ctacggcaac ggtcatgctg 840 ttggcccgag cagttggaga ggatgattgg aaaagagttg ctagtttgag taaacaaacc 900 ttttggcttt ctctgttcct catgttgccc ctgtccttta gtatatatgt cttgggtgta 960 ccattaactc atctctatac gactgattct ctagcggtgg aggctagtgt tctagtgaca 1020 ctgttttcac tacttgggac ccctatgacg acaggaacag tcatctatac ggcagtctgg 1080 cagggattag gaaatgcacg cctccctttt tatgcgacaa gtataggaat gtggtgtatc 1140 cgcattggga caggatatct gatggggatt gtgcttggtt ggggcttgcc tggtatttgg 1200 gcagggtctc tcttggataa tggttttcgc tggttatttc tacgctatcg ttaccagcgc 1260 tatatgagct tgaaaggata g 1281 144 426 PRT Streptococcus pneumoniae 144 Leu Phe Lys Lys Asn Lys Asp Ile Leu Asn Ile Ala Leu Pro Ala Met 1 5 10 15 Gly Glu Asn Phe Leu Gln Met Leu Met Gly Met Val Asp Ser Tyr Leu 20 25 30 Val Ala His Leu Gly Leu Ile Ala Ile Ser Gly Val Ser Val Ala Gly 35 40 45 Asn Ile Ile Thr Ile Tyr Gln Ala Ile Phe Ile Ala Leu Gly Ala Ala 50 55 60 Ile Ser Ser Val Ile Ser Lys Ser Ile Gly Gln Lys Asp Gln Ser Lys 65 70 75 80 Leu Ala Tyr His Val Thr Glu Ala Leu Lys Ile Thr Leu Leu Leu Ser 85 90 95 Phe Leu Leu Gly Phe Leu Ser Ile Phe Ala Gly Lys Glu Met Ile Gly 100 105 110 Leu Leu Gly Thr Glu Arg Asp Val Ala Glu Ser Gly Gly Leu Tyr Leu 115 120 125 Ser Leu Val Gly Gly Ser Ile Val Leu Leu Gly Leu Met Thr Ser Leu 130 135 140 Gly Ala Leu Ile Arg Ala Thr His Asn Pro Arg Leu Pro Leu Tyr Val 145 150 155 160 Ser Phe Leu Ser Asn Ala Leu Asn Ile Leu Phe Ser Ser Leu Ala Ile 165 170 175 Phe Val Leu Asp Met Gly Ile Ala Gly Val Ala Trp Gly Thr Ile Val 180 185 190 Ser Arg Leu Val Gly Leu Val Ile Leu Trp Ser Gln Leu Lys Leu Pro 195 200 205 Tyr Gly Lys Pro Thr Phe Gly Leu Asp Lys Glu Leu Leu Thr Leu Ala 210 215 220 Leu Pro Ala Ala Gly Glu Arg Leu Met Met Arg Ala Gly Asp Val Val 225 230 235 240 Ile Ile Ala Leu Val Val Ser Phe Gly Thr Glu Ala Val Ala Gly Asn 245 250 255 Ala Ile Gly Glu Val Leu Thr Gln Phe Asn Tyr Met Pro Ala Phe Gly 260 265 270 Val Ala Thr Ala Thr Val Met Leu Leu Ala Arg Ala Val Gly Glu Asp 275 280 285 Asp Trp Lys Arg Val Ala Ser Leu Ser Lys Gln Thr Phe Trp Leu Ser 290 295 300 Leu Phe Leu Met Leu Pro Leu Ser Phe Ser Ile Tyr Val Leu Gly Val 305 310 315 320 Pro Leu Thr His Leu Tyr Thr Thr Asp Ser Leu Ala Val Glu Ala Ser 325 330 335 Val Leu Val Thr Leu Phe Ser Leu Leu Gly Thr Pro Met Thr Thr Gly 340 345 350 Thr Val Ile Tyr Thr Ala Val Trp Gln Gly Leu Gly Asn Ala Arg Leu 355 360 365 Pro Phe Tyr Ala Thr Ser Ile Gly Met Trp Cys Ile Arg Ile Gly Thr 370 375 380 Gly Tyr Leu Met Gly Ile Val Leu Gly Trp Gly Leu Pro Gly Ile Trp 385 390 395 400 Ala Gly Ser Leu Leu Asp Asn Gly Phe Arg Trp Leu Phe Leu Arg Tyr 405 410 415 Arg Tyr Gln Arg Tyr Met Ser Leu Lys Gly 420 425 145 894 DNA Streptococcus pneumoniae 145 gtgggaagaa ttatcagagc aggtgtaaag atggaacatc ttggaaaagt atttcgtgaa 60 tttcgaacaa gtggaaatta ttctttaaag gaagcagcag gcgaatcctg ctctacctct 120 cagttatctc gctttgagct tggggagtct gacctggcag tctcccgttt ctttgagatt 180 ttggataaca ttcatgtaac aatcgaaaat ttcatggata aggcaaggaa ttttcataat 240 catgaacatg tgtctatgat ggcacagatt atcccacttt actattcaaa cgatattgca 300 ggttttcaaa agcttcaaag agaacaactt gaaaagtcta agagttcgac gactcccctt 360 tattttgagc tgaactggat tttgctacaa ggtctgattt gtcaaagaga tgcgagttat 420 gatatgaagc aggatgattt gggtaaggta gcagattatc tcttcaaaac agaagaatgg 480 accatgtatg agttgattct tttcggtaac ctctatagtt tctacgatgt agactatgtc 540 actcggattg gtagagaagt tatggagagg gaggaatttt accaagagat tagtcgccat 600 aagagattag tgttgatttt ggccctcaat tgttaccagc attgtttaga gcattcttct 660 ttttataatg ccaactattt tgaggcttat acagagaaga ttattgacaa aggtattaag 720 ctttatgagc gtaatgtttt ccattattta aaaggttttg ccttatatca aaaaggacag 780 tgtaaagaag gctgtaagca gatgcaagag gccatgcata tttttgatgt gttaggtctt 840 ccagagcaag tagcctatta tcaggaacac tacgaaaaat ttgtcaaaag ttaa 894 146 297 PRT Streptococcus pneumoniae 146 Val Gly Arg Ile Ile Arg Ala Gly Val Lys Met Glu His Leu Gly Lys 1 5 10 15 Val Phe Arg Glu Phe Arg Thr Ser Gly Asn Tyr Ser Leu Lys Glu Ala 20 25 30 Ala Gly Glu Ser Cys Ser Thr Ser Gln Leu Ser Arg Phe Glu Leu Gly 35 40 45 Glu Ser Asp Leu Ala Val Ser Arg Phe Phe Glu Ile Leu Asp Asn Ile 50 55 60 His Val Thr Ile Glu Asn Phe Met Asp Lys Ala Arg Asn Phe His Asn 65 70 75 80 His Glu His Val Ser Met Met Ala Gln Ile Ile Pro Leu Tyr Tyr Ser 85 90 95 Asn Asp Ile Ala Gly Phe Gln Lys Leu Gln Arg Glu Gln Leu Glu Lys 100 105 110 Ser Lys Ser Ser Thr Thr Pro Leu Tyr Phe Glu Leu Asn Trp Ile Leu 115 120 125 Leu Gln Gly Leu Ile Cys Gln Arg Asp Ala Ser Tyr Asp Met Lys Gln 130 135 140 Asp Asp Leu Gly Lys Val Ala Asp Tyr Leu Phe Lys Thr Glu Glu Trp 145 150 155 160 Thr Met Tyr Glu Leu Ile Leu Phe Gly Asn Leu Tyr Ser Phe Tyr Asp 165 170 175 Val Asp Tyr Val Thr Arg Ile Gly Arg Glu Val Met Glu Arg Glu Glu 180 185 190 Phe Tyr Gln Glu Ile Ser Arg His Lys Arg Leu Val Leu Ile Leu Ala 195 200 205 Leu Asn Cys Tyr Gln His Cys Leu Glu His Ser Ser Phe Tyr Asn Ala 210 215 220 Asn Tyr Phe Glu Ala Tyr Thr Glu Lys Ile Ile Asp Lys Gly Ile Lys 225 230 235 240 Leu Tyr Glu Arg Asn Val Phe His Tyr Leu Lys Gly Phe Ala Leu Tyr 245 250 255 Gln Lys Gly Gln Cys Lys Glu Gly Cys Lys Gln Met Gln Glu Ala Met 260 265 270 His Ile Phe Asp Val Leu Gly Leu Pro Glu Gln Val Ala Tyr Tyr Gln 275 280 285 Glu His Tyr Glu Lys Phe Val Lys Ser 290 295 147 1068 DNA Streptococcus pneumoniae 147 atgtctaaca ttcaaaacat gtccctggag gacatcatgg gagagcgctt tggtcgctac 60 tccaagtaca ttattcaaga ccgggctttg ccagatattc gtgatgggtt gaagccggtt 120 cagcgccgta ttctttattc tatgaataag gatagcaata cttttgacaa gagctaccgt 180 aagtcggcca agtcagtcgg gaacatcatg gggaatttcc acccacacgg ggattcttct 240 atctatgatg ccatggttcg tatgtcacag aactggaaaa atcgtgagat tctagttgaa 300 atgcacggta ataacggttc tatggacgga gatcctcctg cggctatgcg ttatactgag 360 gcacgtttgt ctgaaattgc aggctacctt cttcaggata tcgagaaaaa gacagttcct 420 tttgcatgga actttgacga tacggagaaa gaaccaacgg tcttgccagc agcctttcca 480 aacctcttgg tcaatggttc gactgggatt tcggctggtt atgccacaga cattcctccc 540 cataatttag ctgaggtcat agatgctgca gtttacatga ttgaccaccc aactgcaaag 600 attgataaac tcatggaatt cttgcctgga ccagacttcc ctacaggggc tattattcag 660 ggtcgtgatg aaatcaagaa agcttatgag actgggaaag ggcgcgtggt tgttcgttcc 720 aagactgaaa ttgaaaagct aaaaggtggt aaggaacaaa tcgttattat tgagattcct 780 tatgaaatca ataaggccaa tctagtcaag aaaatcgatg atgttcgtgt taataacaag 840 gtagctggga ttgctgaggt tcgtgatgag tctgaccgtg atggtcttcg tatcgctatc 900 gaacttaaga aagacgctaa tactgagctt gttctcaact acttatttaa gtacaccgac 960 ctacaaatca actacaactt taatatggtg gcgattgaca atttcacacc tcgtcaggtt 1020 ggattgttcc aatcctgtct agctatatcg ctcaccgtcg agaagtga 1068 148 355 PRT Streptococcus pneumoniae 148 Met Ser Asn Ile Gln Asn Met Ser Leu Glu Asp Ile Met Gly Glu Arg 1 5 10 15 Phe Gly Arg Tyr Ser Lys Tyr Ile Ile Gln Asp Arg Ala Leu Pro Asp 20 25 30 Ile Arg Asp Gly Leu Lys Pro Val Gln Arg Arg Ile Leu Tyr Ser Met 35 40 45 Asn Lys Asp Ser Asn Thr Phe Asp Lys Ser Tyr Arg Lys Ser Ala Lys 50 55 60 Ser Val Gly Asn Ile Met Gly Asn Phe His Pro His Gly Asp Ser Ser 65 70 75 80 Ile Tyr Asp Ala Met Val Arg Met Ser Gln Asn Trp Lys Asn Arg Glu 85 90 95 Ile Leu Val Glu Met His Gly Asn Asn Gly Ser Met Asp Gly Asp Pro 100 105 110 Pro Ala Ala Met Arg Tyr Thr Glu Ala Arg Leu Ser Glu Ile Ala Gly 115 120 125 Tyr Leu Leu Gln Asp Ile Glu Lys Lys Thr Val Pro Phe Ala Trp Asn 130 135 140 Phe Asp Asp Thr Glu Lys Glu Pro Thr Val Leu Pro Ala Ala Phe Pro 145 150 155 160 Asn Leu Leu Val Asn Gly Ser Thr Gly Ile Ser Ala Gly Tyr Ala Thr 165 170 175 Asp Ile Pro Pro His Asn Leu Ala Glu Val Ile Asp Ala Ala Val Tyr 180 185 190 Met Ile Asp His Pro Thr Ala Lys Ile Asp Lys Leu Met Glu Phe Leu 195 200 205 Pro Gly Pro Asp Phe Pro Thr Gly Ala Ile Ile Gln Gly Arg Asp Glu 210 215 220 Ile Lys Lys Ala Tyr Glu Thr Gly Lys Gly Arg Val Val Val Arg Ser 225 230 235 240 Lys Thr Glu Ile Glu Lys Leu Lys Gly Gly Lys Glu Gln Ile Val Ile 245 250 255 Ile Glu Ile Pro Tyr Glu Ile Asn Lys Ala Asn Leu Val Lys Lys Ile 260 265 270 Asp Asp Val Arg Val Asn Asn Lys Val Ala Gly Ile Ala Glu Val Arg 275 280 285 Asp Glu Ser Asp Arg Asp Gly Leu Arg Ile Ala Ile Glu Leu Lys Lys 290 295 300 Asp Ala Asn Thr Glu Leu Val Leu Asn Tyr Leu Phe Lys Tyr Thr Asp 305 310 315 320 Leu Gln Ile Asn Tyr Asn Phe Asn Met Val Ala Ile Asp Asn Phe Thr 325 330 335 Pro Arg Gln Val Gly Leu Phe Gln Ser Cys Leu Ala Ile Ser Leu Thr 340 345 350 Val Glu Lys 355 149 684 DNA Streptococcus pneumoniae 149 atgccgacat tagaaatagc acaaaaaaaa ctggagttca ttaagaaggc agaagaatat 60 tacaatgcct tgtgtacaaa tatacagttg agcggagata aactaaaagt aatttccgtt 120 acttctgtta accctgggga aggaaaaaca actacttcca taaatatagc atggtcgttt 180 gcgcgtgcag gctataaaac tcttttgatc gatggcgata ctcgaaattc agttatgtta 240 ggagttttta aatctcgtga aaaaattaca gggctaacag aatttttatc tgggacagct 300 gatttatctc acggtttatg tgatacaaat attgaaaatt tatttgtagt tcaatcggga 360 tctgtatcac caaaccctac agccttgtta caaagtaaaa attttaatga tatgattgaa 420 acattgcgta aatattttga ttatatcatt attgatacac cgcctattgg aattgttatt 480 gatgcggcaa ttatcactca aaagtgtgat gcgtccatct tggtaacagc aacaggtgag 540 gcgaataaac gtgatatcca aaaagcgaaa caacaattaa aacaaacagg gaaactgttc 600 ctaggagttg ttttaaataa attggatatc tcggttaata agtatggagt ttacggttcc 660 tatggaaatt atggtaaaaa ataa 684 150 227 PRT Streptococcus pneumoniae 150 Met Pro Thr Leu Glu Ile Ala Gln Lys Lys Leu Glu Phe Ile Lys Lys 1 5 10 15 Ala Glu Glu Tyr Tyr Asn Ala Leu Cys Thr Asn Ile Gln Leu Ser Gly 20 25 30 Asp Lys Leu Lys Val Ile Ser Val Thr Ser Val Asn Pro Gly Glu Gly 35 40 45 Lys Thr Thr Thr Ser Ile Asn Ile Ala Trp Ser Phe Ala Arg Ala Gly 50 55 60 Tyr Lys Thr Leu Leu Ile Asp Gly Asp Thr Arg Asn Ser Val Met Leu 65 70 75 80 Gly Val Phe Lys Ser Arg Glu Lys Ile Thr Gly Leu Thr Glu Phe Leu 85 90 95 Ser Gly Thr Ala Asp Leu Ser His Gly Leu Cys Asp Thr Asn Ile Glu 100 105 110 Asn Leu Phe Val Val Gln Ser Gly Ser Val Ser Pro Asn Pro Thr Ala 115 120 125 Leu Leu Gln Ser Lys Asn Phe Asn Asp Met Ile Glu Thr Leu Arg Lys 130 135 140 Tyr Phe Asp Tyr Ile Ile Ile Asp Thr Pro Pro Ile Gly Ile Val Ile 145 150 155 160 Asp Ala Ala Ile Ile Thr Gln Lys Cys Asp Ala Ser Ile Leu Val Thr 165 170 175 Ala Thr Gly Glu Ala Asn Lys Arg Asp Ile Gln Lys Ala Lys Gln Gln 180 185 190 Leu Lys Gln Thr Gly Lys Leu Phe Leu Gly Val Val Leu Asn Lys Leu 195 200 205 Asp Ile Ser Val Asn Lys Tyr Gly Val Tyr Gly Ser Tyr Gly Asn Tyr 210 215 220 Gly Lys Lys 225 151 1194 DNA Streptococcus pneumoniae 151 atggaggcaa atatgaaaca tctaaaaaca ttttacaaaa aatggtttca attattagtc 60 gttatcgtca ttagcttttt tagtggagcc ttgggtagtt tttcaataac tcaactaact 120 caaaaaagta gtgtaaacaa ctctaacaac aatagtacta ttacacaaac tgcctataag 180 aacgaaaatt caacaacaca ggctgttaac aaagtaaaag atgctgttgt ttctgttatt 240 acttattcgg caaacagaca aaatagcgta tttggcaatg atgatactga cacagattct 300 cagcgaatct ctagtgaagg atctggagtt atttataaaa agaatgataa agaagcttac 360 atcgtcacca acaatcacgt tattaatggc gccagcaaag tagatattcg attgtcagat 420 gggactaaag tacctggaga aattgtcgga gctgacactt tctctgatat tgctgtcgtc 480 aaaatctctt cagaaaaagt gacaacagta gctgagtttg gtgattctag taagttaact 540 gtaggagaaa ctgctattgc catcggtagc ccgttaggtt ctgaatatgc aaatactgtc 600 actcaaggta tcgtatccag tctcaataga aatgtatcct taaaatcgga agatggacaa 660 gctatttcta caaaagccat ccaaactgat actgctatta acccaggtaa ctctggcggc 720 ccactgatca atattcaagg gcaggttatc ggaattacct caagtaaaat tgctacaaat 780 ggaggaacat ctgtagaagg tcttggtttc gcaattcctg caaatgatgc tatcaatatt 840 attgaacagt tagaaaaaaa cggaaaagtg acgcgtccag ctttgggaat ccagatggtt 900 aatttatcta atgtgagtac aagcgacatc agaagactca atattccaag taatgttaca 960 tctggtgtaa ttgttcgttc ggtacaaagt aatatgcctg ccaatggtca ccttgaaaaa 1020 tacgatgtaa ttacaaaagt agatgacaaa gagattgctt catcaacaga cttacaaagt 1080 gctctttaca accattctat cggagacacc attaagataa cctactatcg taacgggaaa 1140 gaagaaacta cctctatcaa acttaacaag agttcaggtg atttagaatc ttaa 1194 152 397 PRT Streptococcus pneumoniae 152 Met Glu Ala Asn Met Lys His Leu Lys Thr Phe Tyr Lys Lys Trp Phe 1 5 10 15 Gln Leu Leu Val Val Ile Val Ile Ser Phe Phe Ser Gly Ala Leu Gly 20 25 30 Ser Phe Ser Ile Thr Gln Leu Thr Gln Lys Ser Ser Val Asn Asn Ser 35 40 45 Asn Asn Asn Ser Thr Ile Thr Gln Thr Ala Tyr Lys Asn Glu Asn Ser 50 55 60 Thr Thr Gln Ala Val Asn Lys Val Lys Asp Ala Val Val Ser Val Ile 65 70 75 80 Thr Tyr Ser Ala Asn Arg Gln Asn Ser Val Phe Gly Asn Asp Asp Thr 85 90 95 Asp Thr Asp Ser Gln Arg Ile Ser Ser Glu Gly Ser Gly Val Ile Tyr 100 105 110 Lys Lys Asn Asp Lys Glu Ala Tyr Ile Val Thr Asn Asn His Val Ile 115 120 125 Asn Gly Ala Ser Lys Val Asp Ile Arg Leu Ser Asp Gly Thr Lys Val 130 135 140 Pro Gly Glu Ile Val Gly Ala Asp Thr Phe Ser Asp Ile Ala Val Val 145 150 155 160 Lys Ile Ser Ser Glu Lys Val Thr Thr Val Ala Glu Phe Gly Asp Ser 165 170 175 Ser Lys Leu Thr Val Gly Glu Thr Ala Ile Ala Ile Gly Ser Pro Leu 180 185 190 Gly Ser Glu Tyr Ala Asn Thr Val Thr Gln Gly Ile Val Ser Ser Leu 195 200 205 Asn Arg Asn Val Ser Leu Lys Ser Glu Asp Gly Gln Ala Ile Ser Thr 210 215 220 Lys Ala Ile Gln Thr Asp Thr Ala Ile Asn Pro Gly Asn Ser Gly Gly 225 230 235 240 Pro Leu Ile Asn Ile Gln Gly Gln Val Ile Gly Ile Thr Ser Ser Lys 245 250 255 Ile Ala Thr Asn Gly Gly Thr Ser Val Glu Gly Leu Gly Phe Ala Ile 260 265 270 Pro Ala Asn Asp Ala Ile Asn Ile Ile Glu Gln Leu Glu Lys Asn Gly 275 280 285 Lys Val Thr Arg Pro Ala Leu Gly Ile Gln Met Val Asn Leu Ser Asn 290 295 300 Val Ser Thr Ser Asp Ile Arg Arg Leu Asn Ile Pro Ser Asn Val Thr 305 310 315 320 Ser Gly Val Ile Val Arg Ser Val Gln Ser Asn Met Pro Ala Asn Gly 325 330 335 His Leu Glu Lys Tyr Asp Val Ile Thr Lys Val Asp Asp Lys Glu Ile 340 345 350 Ala Ser Ser Thr Asp Leu Gln Ser Ala Leu Tyr Asn His Ser Ile Gly 355 360 365 Asp Thr Ile Lys Ile Thr Tyr Tyr Arg Asn Gly Lys Glu Glu Thr Thr 370 375 380 Ser Ile Lys Leu Asn Lys Ser Ser Gly Asp Leu Glu Ser 385 390 395 153 939 DNA Streptococcus pneumoniae 153 atggcagaaa tttatctagc aggtggttgt ttttggggcc tagaggaata tttttcacgc 60 atttctggag tgctagaaac cagtgttggc tacgctaatg gtcaagtcga aacgaccaat 120 taccagttgc tcaaggaaac agaccatgca gaaacggtcc aagtgattta cgatgagaag 180 gaagtgtcac tcagagagat tttactttat tatttccgag ttatcgatcc tctatctatc 240 aatcaacaag ggaatgaccg tggtcgccaa tatcgaactg ggatttatta tcaggatgaa 300 gcagatttgc cagctatcta cacagtggtg caggagcagg aacgcatgct gggtcgaaag 360 attgcagtag aagtggagca attacgccac tacattctgg ctgaagacta ccaccaagac 420 tatctcagga agaatccttc aggttactgt catatcgatg tgaccgatgc tgataagcca 480 ttgattgatg cagcaaacta tgaaaagcct agtcaagagg tgttgaaggc cagtctatct 540 gaagagtctt atcgtgtcac acaagaagct gctacagagg ctccatttac caatgcctat 600 gaccaaacct ttgaagaggg gatttatgta gatattacga caggtgagcc actctttttt 660 gccaaggata agtttgcttc aggttgtggt tggccaagtt ttagccgtcc gatttccaaa 720 gagttgattc attattacaa ggatctgagc catggaatgg agcgaattga agttcgttct 780 cgttcaggca gtgctcactt gggtcatgtt ttcacagatg gaccgcggga gttaggcggc 840 ctccgttact gtatcaattc tgcttcttta cgctttgtgg ccaaggatga gatggaaaaa 900 gcaggatatg gctatctatt gccttactta aacaaataa 939 154 312 PRT Streptococcus pneumoniae 154 Met Ala Glu Ile Tyr Leu Ala Gly Gly Cys Phe Trp Gly Leu Glu Glu 1 5 10 15 Tyr Phe Ser Arg Ile Ser Gly Val Leu Glu Thr Ser Val Gly Tyr Ala 20 25 30 Asn Gly Gln Val Glu Thr Thr Asn Tyr Gln Leu Leu Lys Glu Thr Asp 35 40 45 His Ala Glu Thr Val Gln Val Ile Tyr Asp Glu Lys Glu Val Ser Leu 50 55 60 Arg Glu Ile Leu Leu Tyr Tyr Phe Arg Val Ile Asp Pro Leu Ser Ile 65 70 75 80 Asn Gln Gln Gly Asn Asp Arg Gly Arg Gln Tyr Arg Thr Gly Ile Tyr 85 90 95 Tyr Gln Asp Glu Ala Asp Leu Pro Ala Ile Tyr Thr Val Val Gln Glu 100 105 110 Gln Glu Arg Met Leu Gly Arg Lys Ile Ala Val Glu Val Glu Gln Leu 115 120 125 Arg His Tyr Ile Leu Ala Glu Asp Tyr His Gln Asp Tyr Leu Arg Lys 130 135 140 Asn Pro Ser Gly Tyr Cys His Ile Asp Val Thr Asp Ala Asp Lys Pro 145 150 155 160 Leu Ile Asp Ala Ala Asn Tyr Glu Lys Pro Ser Gln Glu Val Leu Lys 165 170 175 Ala Ser Leu Ser Glu Glu Ser Tyr Arg Val Thr Gln Glu Ala Ala Thr 180 185 190 Glu Ala Pro Phe Thr Asn Ala Tyr Asp Gln Thr Phe Glu Glu Gly Ile 195 200 205 Tyr Val Asp Ile Thr Thr Gly Glu Pro Leu Phe Phe Ala Lys Asp Lys 210 215 220 Phe Ala Ser Gly Cys Gly Trp Pro Ser Phe Ser Arg Pro Ile Ser Lys 225 230 235 240 Glu Leu Ile His Tyr Tyr Lys Asp Leu Ser His Gly Met Glu Arg Ile 245 250 255 Glu Val Arg Ser Arg Ser Gly Ser Ala His Leu Gly His Val Phe Thr 260 265 270 Asp Gly Pro Arg Glu Leu Gly Gly Leu Arg Tyr Cys Ile Asn Ser Ala 275 280 285 Ser Leu Arg Phe Val Ala Lys Asp Glu Met Glu Lys Ala Gly Tyr Gly 290 295 300 Tyr Leu Leu Pro Tyr Leu Asn Lys 305 310 155 870 DNA Streptococcus pneumoniae 155 atgaagatta ttgtacctgc aaccagtgcc aatatcgggc caggttttga ctcggtcggt 60 gtagctgtaa ccaagtatct tcaaattgag gtctgcgaag aacgagatga gtggctgatt 120 gaacaccaga ttggcaaatg gattccacat gacgagcgta atctcttgct caaaatcgct 180 ttgcaaattg taccagactt gcaaccaaga cgcttgaaaa tgaccagtga tgtccctttg 240 gcgcgcggtt tgggttcttc cagctcggtt atcgttgctg ggattgaact agccaaccaa 300 ctgggtcaac tcaacttatc agaccatgaa aaattgcagt tagcgaccaa gattgaaggg 360 catcctgaca atgtggctcc agccatttat ggtaatctcg ttattgcaag ttctgttgaa 420 gggcaagtct ctgctatcgt agcagacttt ccagagtgtg attttctagc ttacattcca 480 aactatgaat tacgtactcg cgacagccgt agtgtcttgc ctaaaaaatt gtcttataag 540 gaagctgttg ctgcaagttc tatcgccaat gtagcggttg ctgccttgtt ggcaggagac 600 atggtgaccg ctgggcaagc aatcgaggga gacctcttcc atgagcgcta tcgtcaggac 660 ttggtaagag aatttgcgat gattaagcaa gtgaccaaag aaaatggggc ctatgcaacc 720 tacctttctg gtgctgggcc gacagttatg gttctggctt ctcatgacaa gatgccaaca 780 attaaggcag aattggaaaa gcaacctttc aaaggaaaac tgcatgactt gagagttgat 840 acccaaggtg tccgtgtaga agcaaaataa 870 156 289 PRT Streptococcus pneumoniae 156 Met Lys Ile Ile Val Pro Ala Thr Ser Ala Asn Ile Gly Pro Gly Phe 1 5 10 15 Asp Ser Val Gly Val Ala Val Thr Lys Tyr Leu Gln Ile Glu Val Cys 20 25 30 Glu Glu Arg Asp Glu Trp Leu Ile Glu His Gln Ile Gly Lys Trp Ile 35 40 45 Pro His Asp Glu Arg Asn Leu Leu Leu Lys Ile Ala Leu Gln Ile Val 50 55 60 Pro Asp Leu Gln Pro Arg Arg Leu Lys Met Thr Ser Asp Val Pro Leu 65 70 75 80 Ala Arg Gly Leu Gly Ser Ser Ser Ser Val Ile Val Ala Gly Ile Glu 85 90 95 Leu Ala Asn Gln Leu Gly Gln Leu Asn Leu Ser Asp His Glu Lys Leu 100 105 110 Gln Leu Ala Thr Lys Ile Glu Gly His Pro Asp Asn Val Ala Pro Ala 115 120 125 Ile Tyr Gly Asn Leu Val Ile Ala Ser Ser Val Glu Gly Gln Val Ser 130 135 140 Ala Ile Val Ala Asp Phe Pro Glu Cys Asp Phe Leu Ala Tyr Ile Pro 145 150 155 160 Asn Tyr Glu Leu Arg Thr Arg Asp Ser Arg Ser Val Leu Pro Lys Lys 165 170 175 Leu Ser Tyr Lys Glu Ala Val Ala Ala Ser Ser Ile Ala Asn Val Ala 180 185 190 Val Ala Ala Leu Leu Ala Gly Asp Met Val Thr Ala Gly Gln Ala Ile 195 200 205 Glu Gly Asp Leu Phe His Glu Arg Tyr Arg Gln Asp Leu Val Arg Glu 210 215 220 Phe Ala Met Ile Lys Gln Val Thr Lys Glu Asn Gly Ala Tyr Ala Thr 225 230 235 240 Tyr Leu Ser Gly Ala Gly Pro Thr Val Met Val Leu Ala Ser His Asp 245 250 255 Lys Met Pro Thr Ile Lys Ala Glu Leu Glu Lys Gln Pro Phe Lys Gly 260 265 270 Lys Leu His Asp Leu Arg Val Asp Thr Gln Gly Val Arg Val Glu Ala 275 280 285 Lys 157 564 DNA Streptococcus pneumoniae 157 atgaaatatc acgattacat ctgggattta ggtggaactt tactggataa ttatgaaact 60 tcaacagctg catttgttga aacattggca ctgtatggta tcacacaaga ccatgacagt 120 gtctatcaag ctttaaaggt ttctactcct tttgcgattg agacattcgc tcccaattta 180 gagaattttt tagaaaagta caaggaaaat gaagccagag agcttgaaca cccgatttta 240 tttgaaggag tttctgacct attggaagac atttcaaatc aaggtggccg tcattttttg 300 gtctctcatc gaaatgatca ggttttggaa attttagaaa aaacctctat agcagcttat 360 tttacagaag tggtgacttc tagctcaggc tttaagagaa agccaaatcc cgaatccatg 420 ctttatttaa gagaaaagta tcagattagc tctggtcttg tcattggtga tcggccgatt 480 gatatcgaag caggtcaagc tgcaggactt gatacccact tgtttaccag tatcgtgaat 540 ttaagacaag tattagacat ataa 564 158 187 PRT Streptococcus pneumoniae 158 Met Lys Tyr His Asp Tyr Ile Trp Asp Leu Gly Gly Thr Leu Leu Asp 1 5 10 15 Asn Tyr Glu Thr Ser Thr Ala Ala Phe Val Glu Thr Leu Ala Leu Tyr 20 25 30 Gly Ile Thr Gln Asp His Asp Ser Val Tyr Gln Ala Leu Lys Val Ser 35 40 45 Thr Pro Phe Ala Ile Glu Thr Phe Ala Pro Asn Leu Glu Asn Phe Leu 50 55 60 Glu Lys Tyr Lys Glu Asn Glu Ala Arg Glu Leu Glu His Pro Ile Leu 65 70 75 80 Phe Glu Gly Val Ser Asp Leu Leu Glu Asp Ile Ser Asn Gln Gly Gly 85 90 95 Arg His Phe Leu Val Ser His Arg Asn Asp Gln Val Leu Glu Ile Leu 100 105 110 Glu Lys Thr Ser Ile Ala Ala Tyr Phe Thr Glu Val Val Thr Ser Ser 115 120 125 Ser Gly Phe Lys Arg Lys Pro Asn Pro Glu Ser Met Leu Tyr Leu Arg 130 135 140 Glu Lys Tyr Gln Ile Ser Ser Gly Leu Val Ile Gly Asp Arg Pro Ile 145 150 155 160 Asp Ile Glu Ala Gly Gln Ala Ala Gly Leu Asp Thr His Leu Phe Thr 165 170 175 Ser Ile Val Asn Leu Arg Gln Val Leu Asp Ile 180 185 159 1875 DNA Streptococcus pneumoniae 159 atgacagaag aaatcaaaaa tctgcaggca caggattatg atgccagtca aattcaagtt 60 ttagagggct tagaggctgt tcgtatgcgt ccagggatgt acattggatc aacctcaaaa 120 gaaggtcttc accatctagt ctgggaaatt gttgataact caattgacga ggccttggca 180 ggatttgcca gccatattca agtttttatt gagccagatg attcgattac tgttgtggat 240 gatgggcgtg gtatcccagt cgatattcag gaaaaaacag gccgtcctgc tgttgagacc 300 gtctttacag tccttcacgc tggaggaaag ttcggcggtg gtggatacaa ggtttcaggt 360 ggtcttcacg gggtggggtc gtcagtagtt aatgcccttt ccactcaatt agacgttcat 420 gttcacaaaa atggtaagat tcattaccaa gaataccgtc gtggtcatgt tgtcgcagat 480 cttgaaatag ttggagatac ggataaaaca ggaacaactg ttcacttcac accggaccca 540 aaaatcttca ctgaaacaac aatctttgat tttgataaat taaataaacg gattcaagag 600 ttggcctttc taaatcgcgg tcttcaaatt tcaattacag ataagcgcca aggtttggaa 660 caaaccaagc attatcatta tgaaggtggg attgctagtt acgttgaata tatcaacgag 720 aacaaggatg taatctttga tacaccaatc tatacagacg gtgagatgga tgatatcaca 780 gttgaggtag ccatgcagta cacaactggt taccatgaaa atgtcatgag tttcgccaat 840 aatattcata cccatgaagg tggaacacat gaacaaggtt tccgtacagc cttgacacgt 900 gttatcaacg attatgctcg taaaaataag ttactgaaag acaatgaaga taatttaaca 960 ggggaagatg ttcgcgaagg cttaactgca gttatctcag ttaaacaccc aaatccacag 1020 tttgaaggac aaaccaagac caaattggga aatagcgaag tggtcaagat taccaatcgc 1080 ctcttcagtg aagctttctc cgatttcctc atggaaaatc cacagattgc caaacgtatc 1140 gtagaaaaag gaattttggc tgccaaggct cgtgtggctg ccaagcgtgc gcgtgaagtc 1200 acacgtaaaa aatctggttt ggaaatttcc aaccttccag ggaaactagc agactgttct 1260 tctaataacc ctgctgaaac agaactcttc atcgtcgaag gagactcagc tggtggatca 1320 gccaaatctg gtcgtaaccg tgagtttcag gctatccttc caattcgcgg taagattttg 1380 aacgttgaaa aagcaagtat ggataagatt ctagccaacg aagaaattcg tagtcttttc 1440 acagccatgg gaacaggatt tggcgcagaa tttgatgttt cgaaagcccg ttaccaaaaa 1500 ctcgttttga tgaccgatgc cgatgtcgat ggagcccaca ttcgtaccct tcttttaacc 1560 ttgatttatc gttatatgaa accaatccta gaagctggtt atgtttatat tgcccaacca 1620 ccaatctatg gtgtcaaggt tggaagcgag attaaagaat atatccagcc gggtgcagat 1680 caagaaatca aactccaaga agctttagcc cgttatagtg aaggtcgtac caaaccgact 1740 attcagcgtt ataaggggct aggtgaaatg gacgatcatc agctgtggga aacaaccatg 1800 gatcccgaac atcgcttgat ggctagagtt tctgtagatg atgtgcagaa gcagataaaa 1860 tctttgatat gttga 1875 160 624 PRT Streptococcus pneumoniae 160 Met Thr Glu Glu Ile Lys Asn Leu Gln Ala Gln Asp Tyr Asp Ala Ser 1 5 10 15 Gln Ile Gln Val Leu Glu Gly Leu Glu Ala Val Arg Met Arg Pro Gly 20 25 30 Met Tyr Ile Gly Ser Thr Ser Lys Glu Gly Leu His His Leu Val Trp 35 40 45 Glu Ile Val Asp Asn Ser Ile Asp Glu Ala Leu Ala Gly Phe Ala Ser 50 55 60 His Ile Gln Val Phe Ile Glu Pro Asp Asp Ser Ile Thr Val Val Asp 65 70 75 80 Asp Gly Arg Gly Ile Pro Val Asp Ile Gln Glu Lys Thr Gly Arg Pro 85 90 95 Ala Val Glu Thr Val Phe Thr Val Leu His Ala Gly Gly Lys Phe Gly 100 105 110 Gly Gly Gly Tyr Lys Val Ser Gly Gly Leu His Gly Val Gly Ser Ser 115 120 125 Val Val Asn Ala Leu Ser Thr Gln Leu Asp Val His Val His Lys Asn 130 135 140 Gly Lys Ile His Tyr Gln Glu Tyr Arg Arg Gly His Val Val Ala Asp 145 150 155 160 Leu Glu Ile Val Gly Asp Thr Asp Lys Thr Gly Thr Thr Val His Phe 165 170 175 Thr Pro Asp Pro Lys Ile Phe Thr Glu Thr Thr Ile Phe Asp Phe Asp 180 185 190 Lys Leu Asn Lys Arg Ile Gln Glu Leu Ala Phe Leu Asn Arg Gly Leu 195 200 205 Gln Ile Ser Ile Thr Asp Lys Arg Gln Gly Leu Glu Gln Thr Lys His 210 215 220 Tyr His Tyr Glu Gly Gly Ile Ala Ser Tyr Val Glu Tyr Ile Asn Glu 225 230 235 240 Asn Lys Asp Val Ile Phe Asp Thr Pro Ile Tyr Thr Asp Gly Glu Met 245 250 255 Asp Asp Ile Thr Val Glu Val Ala Met Gln Tyr Thr Thr Gly Tyr His 260 265 270 Glu Asn Val Met Ser Phe Ala Asn Asn Ile His Thr His Glu Gly Gly 275 280 285 Thr His Glu Gln Gly Phe Arg Thr Ala Leu Thr Arg Val Ile Asn Asp 290 295 300 Tyr Ala Arg Lys Asn Lys Leu Leu Lys Asp Asn Glu Asp Asn Leu Thr 305 310 315 320 Gly Glu Asp Val Arg Glu Gly Leu Thr Ala Val Ile Ser Val Lys His 325 330 335 Pro Asn Pro Gln Phe Glu Gly Gln Thr Lys Thr Lys Leu Gly Asn Ser 340 345 350 Glu Val Val Lys Ile Thr Asn Arg Leu Phe Ser Glu Ala Phe Ser Asp 355 360 365 Phe Leu Met Glu Asn Pro Gln Ile Ala Lys Arg Ile Val Glu Lys Gly 370 375 380 Ile Leu Ala Ala Lys Ala Arg Val Ala Ala Lys Arg Ala Arg Glu Val 385 390 395 400 Thr Arg Lys Lys Ser Gly Leu Glu Ile Ser Asn Leu Pro Gly Lys Leu 405 410 415 Ala Asp Cys Ser Ser Asn Asn Pro Ala Glu Thr Glu Leu Phe Ile Val 420 425 430 Glu Gly Asp Ser Ala Gly Gly Ser Ala Lys Ser Gly Arg Asn Arg Glu 435 440 445 Phe Gln Ala Ile Leu Pro Ile Arg Gly Lys Ile Leu Asn Val Glu Lys 450 455 460 Ala Ser Met Asp Lys Ile Leu Ala Asn Glu Glu Ile Arg Ser Leu Phe 465 470 475 480 Thr Ala Met Gly Thr Gly Phe Gly Ala Glu Phe Asp Val Ser Lys Ala 485 490 495 Arg Tyr Gln Lys Leu Val Leu Met Thr Asp Ala Asp Val Asp Gly Ala 500 505 510 His Ile Arg Thr Leu Leu Leu Thr Leu Ile Tyr Arg Tyr Met Lys Pro 515 520 525 Ile Leu Glu Ala Gly Tyr Val Tyr Ile Ala Gln Pro Pro Ile Tyr Gly 530 535 540 Val Lys Val Gly Ser Glu Ile Lys Glu Tyr Ile Gln Pro Gly Ala Asp 545 550 555 560 Gln Glu Ile Lys Leu Gln Glu Ala Leu Ala Arg Tyr Ser Glu Gly Arg 565 570 575 Thr Lys Pro Thr Ile Gln Arg Tyr Lys Gly Leu Gly Glu Met Asp Asp 580 585 590 His Gln Leu Trp Glu Thr Thr Met Asp Pro Glu His Arg Leu Met Ala 595 600 605 Arg Val Ser Val Asp Asp Val Gln Lys Gln Ile Lys Ser Leu Ile Cys 610 615 620 161 1446 DNA Streptococcus pneumoniae 161 atgagtagac gttttaaaaa atcacgttca cagaaagtga agcgaagtgt taatatagtt 60 ttgctgacta tttatttatt gttagtttgt tttttattgt tcttaatctt taagtacaat 120 atccttgctt ttagatatct taatctagtg gtaactgcgt tagtcctact agttgccttg 180 gtagggctac tcttgattat ctataaaaaa gctgaaaagt ttactatttt tctgttggtg 240 ttctctatcc ttgtcagctc tgtgtcgctc tttgcagtac agcagtttgt tggactgacc 300 aatcgtttaa atgcgacttc taattactca gaatattcaa tcagtgtcgc tgttttagca 360 gatagtgaga tcgaaaatgt tacgcaactg acgagtgtga cagcaccgac tgggactaat 420 aatgaaaata ttcagaaatt actagctgat atcaagtcaa gtcagaatac cgatttgacg 480 gtcaaccaga gttcgtctta cttggcagct tacaagagtt tgattgcagg ggagactaag 540 gccattgtcc taaatagtgt ctttgaaaac atcatcgagt cagagtatcc agactacgca 600 tcgaagataa aaaagattta tactaaggga ttcactaaaa aagtagaagc tcctaagacg 660 tctaagagtc agtctttcaa tatctatgtt agtggaattg acacctatgg tcctattagt 720 tcggtgtcgc gatcagatgt caacatcctg atgactgtca atcgagatac caagaaaatc 780 ctcttgacca caacgccacg tgatgcctat gtaccaatcg cagatggtgg aaataatcaa 840 aaagataaat tgactcatgc gggcatttat ggagttgatt cgtccattca caccttagaa 900 aatctctatg gagtggatat caattactat gtgcgattga acttcacttc gtttttgaaa 960 ttgattgatt tgttgggtgg aattgatgtt tataatgatc aagaatttac tgcccatacg 1020 aatggaaagt attaccctgc aggcaatgtt catcttgatt cagaacaggc tctcggtttt 1080 gttcgtgagc gctactccct agcagatggc gatcgtgacc gcgggcgcca tcaacaaaag 1140 gtgattgtgg ctatccttca aaaattaacg tcaaccgaag tgctgaaaaa ttatagtacg 1200 atcattaata gcttgcaaga ttctatccaa acaaatatgc cacttgagac catgataaat 1260 ttggtcaatg ctcagttaga aagtggaggg aattataaag taaattctca agatttaaaa 1320 gggacaggtc ggatggatct tccttcttat gcaatgccag acagtaacct ctatgtgatg 1380 gaaatagatg atagtagttt agctgtagtt aaagcagcta tacaggatgt gatggagggt 1440 agatga 1446 162 481 PRT Streptococcus pneumoniae 162 Met Ser Arg Arg Phe Lys Lys Ser Arg Ser Gln Lys Val Lys Arg Ser 1 5 10 15 Val Asn Ile Val Leu Leu Thr Ile Tyr Leu Leu Leu Val Cys Phe Leu 20 25 30 Leu Phe Leu Ile Phe Lys Tyr Asn Ile Leu Ala Phe Arg Tyr Leu Asn 35 40 45 Leu Val Val Thr Ala Leu Val Leu Leu Val Ala Leu Val Gly Leu Leu 50 55 60 Leu Ile Ile Tyr Lys Lys Ala Glu Lys Phe Thr Ile Phe Leu Leu Val 65 70 75 80 Phe Ser Ile Leu Val Ser Ser Val Ser Leu Phe Ala Val Gln Gln Phe 85 90 95 Val Gly Leu Thr Asn Arg Leu Asn Ala Thr Ser Asn Tyr Ser Glu Tyr 100 105 110 Ser Ile Ser Val Ala Val Leu Ala Asp Ser Glu Ile Glu Asn Val Thr 115 120 125 Gln Leu Thr Ser Val Thr Ala Pro Thr Gly Thr Asn Asn Glu Asn Ile 130 135 140 Gln Lys Leu Leu Ala Asp Ile Lys Ser Ser Gln Asn Thr Asp Leu Thr 145 150 155 160 Val Asn Gln Ser Ser Ser Tyr Leu Ala Ala Tyr Lys Ser Leu Ile Ala 165 170 175 Gly Glu Thr Lys Ala Ile Val Leu Asn Ser Val Phe Glu Asn Ile Ile 180 185 190 Glu Ser Glu Tyr Pro Asp Tyr Ala Ser Lys Ile Lys Lys Ile Tyr Thr 195 200 205 Lys Gly Phe Thr Lys Lys Val Glu Ala Pro Lys Thr Ser Lys Ser Gln 210 215 220 Ser Phe Asn Ile Tyr Val Ser Gly Ile Asp Thr Tyr Gly Pro Ile Ser 225 230 235 240 Ser Val Ser Arg Ser Asp Val Asn Ile Leu Met Thr Val Asn Arg Asp 245 250 255 Thr Lys Lys Ile Leu Leu Thr Thr Thr Pro Arg Asp Ala Tyr Val Pro 260 265 270 Ile Ala Asp Gly Gly Asn Asn Gln Lys Asp Lys Leu Thr His Ala Gly 275 280 285 Ile Tyr Gly Val Asp Ser Ser Ile His Thr Leu Glu Asn Leu Tyr Gly 290 295 300 Val Asp Ile Asn Tyr Tyr Val Arg Leu Asn Phe Thr Ser Phe Leu Lys 305 310 315 320 Leu Ile Asp Leu Leu Gly Gly Ile Asp Val Tyr Asn Asp Gln Glu Phe 325 330 335 Thr Ala His Thr Asn Gly Lys Tyr Tyr Pro Ala Gly Asn Val His Leu 340 345 350 Asp Ser Glu Gln Ala Leu Gly Phe Val Arg Glu Arg Tyr Ser Leu Ala 355 360 365 Asp Gly Asp Arg Asp Arg Gly Arg His Gln Gln Lys Val Ile Val Ala 370 375 380 Ile Leu Gln Lys Leu Thr Ser Thr Glu Val Leu Lys Asn Tyr Ser Thr 385 390 395 400 Ile Ile Asn Ser Leu Gln Asp Ser Ile Gln Thr Asn Met Pro Leu Glu 405 410 415 Thr Met Ile Asn Leu Val Asn Ala Gln Leu Glu Ser Gly Gly Asn Tyr 420 425 430 Lys Val Asn Ser Gln Asp Leu Lys Gly Thr Gly Arg Met Asp Leu Pro 435 440 445 Ser Tyr Ala Met Pro Asp Ser Asn Leu Tyr Val Met Glu Ile Asp Asp 450 455 460 Ser Ser Leu Ala Val Val Lys Ala Ala Ile Gln Asp Val Met Glu Gly 465 470 475 480 Arg 163 732 DNA Streptococcus pneumoniae 163 atgatagaca tccattcgca tatcgttttt gatgtagatg acggtcccaa gtcaagagag 60 gaaagcaagg ctctcttggc agaatcctac agacaggggg tgcgaaccat tgtttctacc 120 tctcaccgtc gcaagggcat gtttgaaact ccggaagaga agatagcaga aaactttctt 180 caggttcggg aaatagctaa ggaagtggcg agtgacttgg tcattgctta cggggctgaa 240 atttattaca caccagatgt tctggataag ctggaaaaaa agcggattcc gaccctcaat 300 gatagtcgtt atgccttgat agagtttagt atgaacactc cttatcgcga tattcatagc 360 gccttgagca agatcttgat gttgggaatt actccagtca ttgcccacat tgagcgctat 420 gatgctcttg aaaataatga aaaacgcgtt cgagaactga tcgatatggg ctgttacacg 480 caagtaaata gttcacatgt cctcaaaccc aaactttttg gcgaacgtta taaattcatg 540 aaaaaaagag ctcagtattt tttagagcag gatttggttc atgtcattgc aagtgatatg 600 cacaatctag acggtagacc tcctcatatg gcagaagcat atgaccttgt tacccaaaaa 660 tacggagaag cgaaggctca ggaacttttt atagacaatc ctcgaaaaat tgtaatggat 720 caactaattt ag 732 164 243 PRT Streptococcus pneumoniae 164 Met Ile Asp Ile His Ser His Ile Val Phe Asp Val Asp Asp Gly Pro 1 5 10 15 Lys Ser Arg Glu Glu Ser Lys Ala Leu Leu Ala Glu Ser Tyr Arg Gln 20 25 30 Gly Val Arg Thr Ile Val Ser Thr Ser His Arg Arg Lys Gly Met Phe 35 40 45 Glu Thr Pro Glu Glu Lys Ile Ala Glu Asn Phe Leu Gln Val Arg Glu 50 55 60 Ile Ala Lys Glu Val Ala Ser Asp Leu Val Ile Ala Tyr Gly Ala Glu 65 70 75 80 Ile Tyr Tyr Thr Pro Asp Val Leu Asp Lys Leu Glu Lys Lys Arg Ile 85 90 95 Pro Thr Leu Asn Asp Ser Arg Tyr Ala Leu Ile Glu Phe Ser Met Asn 100 105 110 Thr Pro Tyr Arg Asp Ile His Ser Ala Leu Ser Lys Ile Leu Met Leu 115 120 125 Gly Ile Thr Pro Val Ile Ala His Ile Glu Arg Tyr Asp Ala Leu Glu 130 135 140 Asn Asn Glu Lys Arg Val Arg Glu Leu Ile Asp Met Gly Cys Tyr Thr 145 150 155 160 Gln Val Asn Ser Ser His Val Leu Lys Pro Lys Leu Phe Gly Glu Arg 165 170 175 Tyr Lys Phe Met Lys Lys Arg Ala Gln Tyr Phe Leu Glu Gln Asp Leu 180 185 190 Val His Val Ile Ala Ser Asp Met His Asn Leu Asp Gly Arg Pro Pro 195 200 205 His Met Ala Glu Ala Tyr Asp Leu Val Thr Gln Lys Tyr Gly Glu Ala 210 215 220 Lys Ala Gln Glu Leu Phe Ile Asp Asn Pro Arg Lys Ile Val Met Asp 225 230 235 240 Gln Leu Ile 165 3990 DNA Streptococcus pneumoniae 165 ttgatttata taatcgctat caatataaca atgcaatcag gaggttttgc aatgaaacat 60 gaaaaacaac agcgtttttc tattcgtaaa tacgctgtag gagcagcttc tgttctaatt 120 ggatttgcct tccaagcaca gactgttgca gccgatggag ttactcctac tactacagaa 180 aaccaaccga ccatccatac ggtttctgat tcccctcaat catccgaaaa tcggactgag 240 gaaacaccta aagcagtgct tcaaccagaa gctccaaaaa ctgtagaaac agaaactcca 300 gctactgata aggtagctag tcttccaaaa acagaagaaa aaccacaaga ggaagttagt 360 tcaactccta gtgataaagc agaagtggta actccaactt ctgctgaaaa agaaactgct 420 aataaaaagg cagaagaagc tagccctaaa aaggaagaag cgaaagaggt tgattctaaa 480 gagtcaaata cagacaagac tgacaaggat aaaccagcta aaaaagatga agcgaaagca 540 gaggctgaca aaccggcaac agaggcagga aaggaacgtg ctgcaactgt aaatgaaaaa 600 ctagcgaaaa agaaaattgt ttctattgat gctggacgta aatatttctc accagaacag 660 ctcaaggaaa tcatcgataa agcgaaacat tatggctaca ctgatttaca cctattagtc 720 ggaaatgatg gactccgttt catgttggac gatatgagca tcacagctaa cggcaagacc 780 tatgccagtg acgatgtcaa acgcgccatt gaaaaaggta caaatgatta ttacaacgat 840 ccaaacggca atcacttaac agaaagtcaa atgacagatc tgattaacta tgccaaagat 900 aaaggtatcg gtctcattcc gacagtaaat agtcctggac acatggatgc gattctcaat 960 gccatgaaag aattgggaat ccaaaaccct aactttagct attttgggaa gaaatcagcc 1020 cgtactgtcg atcttgacaa cgaacaagct gtcgctttta caaaagccct tatcgacaag 1080 tatgctgctt atttcgcgaa aaagactgaa atcttcaaca tcggacttga tgaatatgcc 1140 aatgatgcga cagatgctaa aggttggagt gtgcttcaag ctgataaata ctatccaaac 1200 gaaggctacc ctgtaaaagg ctatgaaaaa tttattgcct acgccaatga cctcgctcgt 1260 attgtaaaat cgcacggtct caaaccaatg gcttttaacg acggtatcta ctacaatagc 1320 gacacaagct ttggtagttt tgacaaagac atcatcgttt ctatgtggac tggtggttgg 1380 ggaggctacg atgtcgcttc ttctaaacta ctagctgaaa aaggtcacca aatccttaat 1440 accaatgatg cttggtacta cgttcttgga cgaaacgctg atggccaagg ctggtacaat 1500 ctcgatcagg ggctcaatgg tattaaaaac acaccaatca cttctgtacc aaaaacagaa 1560 ggagctgata tcccaatcat cggtggtatg gtagctgctt gggctgacac tccatctgca 1620 cgttattcac catcacgcct cttcaaactc atgcgtcatt ttgcaaatgc caacgctgaa 1680 tacttcgcag ctgattatga atctgcagag caagcactta acgaggtacc aaaagacctg 1740 aaccgttata ctgcagaaag cgtcacggcc gtaaaagaag ctgaaaaagc tattcgctct 1800 ctcgatagca accttagccg tgcccaacaa gatacgattg atcaagccat tgctaaactt 1860 caagaaactg tcaacaactt gaccctcacg cctgaagctc aaaaagaaga agaagctaaa 1920 cgtgaggttg aaaaacttgc caaaaacaag gtaatctcaa tcgatgctgg acgcaaatac 1980 tttactctga accagctcaa acgcatcgta gacaaggcca gtgagctcgg atattctgat 2040 gtccatctcc ttctaggaaa tgacggactt cgctttctac tcgatgatat gaccattact 2100 gccaacggaa aaacctatgc tagtgatgac gttaaaaaag ctattatcga aggaactaaa 2160 gcttactacg acgatccaaa cggtactgca ctaacacagg cagaagtaac agagctaatt 2220 gaatacgcta aatctaagga catcggtctc atcccagcta ttaacagtcc aggtcacatg 2280 gatgctatgc tggttgccat ggaaaaatta ggtattaaaa atcctcaagc ccactttgat 2340 aaagtttcaa aaacaactat ggacttgaaa aacgaagaag cgatgaactt tgtaaaagcc 2400 ctcatcggta aatacatgga cttctttgca ggtaaaacaa agattttcaa ctttggtact 2460 gacgaatacg ccaacgatgc gactagtgcc caaggctggt actacctcaa gtggtatcaa 2520 ctctatggca aatttgccga atatgccaac accctcgcag ctatggccaa agaaagaggg 2580 cttcaaccaa tggccttcaa cgatggcttc tactatgaag acaaggacga tgttcagttt 2640 gacaaagatg tcttgatttc ttactggtct aaaggctggt ggggatataa cctcgcatca 2700 cctcaatacc tagcaagcaa aggctataaa ttcttgaata ccaacggtga ctggtactac 2760 attcttggtc aaaaaccaga agatggtggt ggtttcctca agaaagctat tgagaatact 2820 ggaaaaacac cattcaatca actagcttct accaaatatc ctgaagtaga tcttccaaca 2880 gtcggaagta tgctttcaat ctgggcagat agaccaagcg ctgaatacaa ggaagaggaa 2940 atctttgaac tcatgactgc ctttgcagac cacaacaaag actactttcg tgctaattat 3000 aatgctctcc gcgaagaatt agctaaaatt cctacaaact tagaaggata tagtaaagaa 3060 agtcttgagg cccttgacgc agctaaaaca gctctaaatt acaacctcaa ccgtaataaa 3120 caagctgagc ttgacacgct tgtagccaac ctaaaagccg ctcttcaagg cctcaaacca 3180 gctgtaactc attcaggaag cctagatgaa aatgaagtgg ctgccaatgt tgaaaccaga 3240 ccagaactca tcacaagaac tgaagaaatt ccatttgaag ttatcaagaa agaaaatcct 3300 aacctcccag ccggtcagga aaatattatc acagcaggag tcaaaggtga acgaactcat 3360 tacatctctg tactcactga aaatggaaaa acaacagaaa cagtccttga tagccaggta 3420 accaaagaag ttataaacca agtggttgaa gttggcgctc ctgtaactca caagggtgat 3480 gaaagtggtc ttgcaccaac tactgaggta aaacctagac tggatatcca agaagaagaa 3540 attccattta ccacagtgac ttgtgaaaat ccactcttac tcaaaggaaa aacacaagtc 3600 attactaagg gcgtcaatgg acatcgtagc aacttctact ctgtgagcac ttctgccgat 3660 ggtaaggaag tgaaaacact tgtaaatagt gtcgtagcac aggaagccgt tactcaaata 3720 gtcgaagtcg gaactatggt aacacatgta ggcgatgaaa acggacaagc cgctattgct 3780 gaagaaaaac caaaactaga aatcccaagc caaccagctc catcaactgc tcctgctgag 3840 gaaagcaaag ttcttcctca agatccagct cctgtggtaa cagagaaaaa acttcctgaa 3900 acaggaactc acgattctgc aggactagta gtcgcaggac tcatgtccac actagcagcc 3960 tatggactca ctaaaagaaa agaagactaa 3990 166 1329 PRT Streptococcus pneumoniae 166 Met Ile Tyr Ile Ile Ala Ile Asn Ile Thr Met Gln Ser Gly Gly Phe 1 5 10 15 Ala Met Lys His Glu Lys Gln Gln Arg Phe Ser Ile Arg Lys Tyr Ala 20 25 30 Val Gly Ala Ala Ser Val Leu Ile Gly Phe Ala Phe Gln Ala Gln Thr 35 40 45 Val Ala Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr 50 55 60 Ile His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu 65 70 75 80 Glu Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu 85 90 95 Thr Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu 100 105 110 Glu Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu 115 120 125 Val Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala 130 135 140 Glu Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys 145 150 155 160 Glu Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp 165 170 175 Glu Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu 180 185 190 Arg Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser 195 200 205 Ile Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile 210 215 220 Ile Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val 225 230 235 240 Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala 245 250 255 Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys 260 265 270 Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu 275 280 285 Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly 290 295 300 Leu Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn 305 310 315 320 Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly 325 330 335 Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala 340 345 350 Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys 355 360 365 Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr 370 375 380 Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn 385 390 395 400 Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn 405 410 415 Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe 420 425 430 Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp 435 440 445 Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp 450 455 460 Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn 465 470 475 480 Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln 485 490 495 Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro 500 505 510 Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly 515 520 525 Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro 530 535 540 Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu 545 550 555 560 Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val 565 570 575 Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys 580 585 590 Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala 595 600 605 Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val 610 615 620 Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys 625 630 635 640 Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala 645 650 655 Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys 660 665 670 Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp 675 680 685 Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys 690 695 700 Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys 705 710 715 720 Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val 725 730 735 Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro 740 745 750 Ala Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu 755 760 765 Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys 770 775 780 Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala 785 790 795 800 Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe 805 810 815 Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly 820 825 830 Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr 835 840 845 Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met 850 855 860 Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe 865 870 875 880 Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr 885 890 895 Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu 900 905 910 Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp 915 920 925 Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro 930 935 940 Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr 945 950 955 960 Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr 965 970 975 Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn 980 985 990 Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala 995 1000 1005 Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala 1010 1015 1020 Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys 1025 1030 1035 1040 Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln 1045 1050 1055 Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu 1060 1065 1070 Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu 1075 1080 1085 Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala 1090 1095 1100 Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His 1105 1110 1115 1120 Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu 1125 1130 1135 Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly 1140 1145 1150 Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr 1155 1160 1165 Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr 1170 1175 1180 Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val 1185 1190 1195 1200 Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser 1205 1210 1215 Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val 1220 1225 1230 Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr 1235 1240 1245 His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro 1250 1255 1260 Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu 1265 1270 1275 1280 Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys 1285 1290 1295 Lys Leu Pro Glu Thr Gly Thr His Asp Ser Ala Gly Leu Val Val Ala 1300 1305 1310 Gly Leu Met Ser Thr Leu Ala Ala Tyr Gly Leu Thr Lys Arg Lys Glu 1315 1320 1325 Asp 167 825 DNA Streptococcus pneumoniae 167 atgaacaaaa aaacaagaca gacactaatc ggactgctag tgttattgct tttgtctaca 60 gggagctatt atatcaagca gatgccgtcg gcacctaata gtcccaaaac caatcttagt 120 cagaaaaaac aagcgtctga agctcctagt caagcattgg cagagagtgt cttaacagac 180 gcagtcaaga gtcaaataaa ggggagtctg gagtggaatg gctcaggtgc ttttatcgtc 240 aatggtaata aaacaaatct agatgccaag gtttcaagta agccctacgc tgacaataaa 300 acaaagacag tgggcaagga aactgttcca accgtagcta atgccctctt gtctaaggcc 360 actcgtcagt acaagaatcg taaagaaact gggaatggtt caacttcttg gactcctcca 420 ggttggcatc aggtcaagaa tctaaagggc tcttataccc atgcagtcga tagaggtcat 480 ttgttaggct atgccttaat cggtggtttg gatggttttg atgcctcaac aagcaatcct 540 aaaaacattg ctgttcagac agcctgggca aatcaggcac aagccgagta ttcgactggt 600 caaaactact atgaaagcaa ggtgcgtaaa gccttggacc aaaacaagcg tgtccgttac 660 cgtgtaaccc tttactacgc ttcaaacgag gatttagttc cctcagcttc acagattgaa 720 gccaagtctt cggatggaga attggaattc aatgttctag ttcccaatgt tcaaaaggga 780 cttcaactgg attaccgaac tggagaagta actgtaactc agtaa 825 168 274 PRT Streptococcus pneumoniae 168 Met Asn Lys Lys Thr Arg Gln Thr Leu Ile Gly Leu Leu Val Leu Leu 1 5 10 15 Leu Leu Ser Thr Gly Ser Tyr Tyr Ile Lys Gln Met Pro Ser Ala Pro 20 25 30 Asn Ser Pro Lys Thr Asn Leu Ser Gln Lys Lys Gln Ala Ser Glu Ala 35 40 45 Pro Ser Gln Ala Leu Ala Glu Ser Val Leu Thr Asp Ala Val Lys Ser 50 55 60 Gln Ile Lys Gly Ser Leu Glu Trp Asn Gly Ser Gly Ala Phe Ile Val 65 70 75 80 Asn Gly Asn Lys Thr Asn Leu Asp Ala Lys Val Ser Ser Lys Pro Tyr 85 90 95 Ala Asp Asn Lys Thr Lys Thr Val Gly Lys Glu Thr Val Pro Thr Val 100 105 110 Ala Asn Ala Leu Leu Ser Lys Ala Thr Arg Gln Tyr Lys Asn Arg Lys 115 120 125 Glu Thr Gly Asn Gly Ser Thr Ser Trp Thr Pro Pro Gly Trp His Gln 130 135 140 Val Lys Asn Leu Lys Gly Ser Tyr Thr His Ala Val Asp Arg Gly His 145 150 155 160 Leu Leu Gly Tyr Ala Leu Ile Gly Gly Leu Asp Gly Phe Asp Ala Ser 165 170 175 Thr Ser Asn Pro Lys Asn Ile Ala Val Gln Thr Ala Trp Ala Asn Gln 180 185 190 Ala Gln Ala Glu Tyr Ser Thr Gly Gln Asn Tyr Tyr Glu Ser Lys Val 195 200 205 Arg Lys Ala Leu Asp Gln Asn Lys Arg Val Arg Tyr Arg Val Thr Leu 210 215 220 Tyr Tyr Ala Ser Asn Glu Asp Leu Val Pro Ser Ala Ser Gln Ile Glu 225 230 235 240 Ala Lys Ser Ser Asp Gly Glu Leu Glu Phe Asn Val Leu Val Pro Asn 245 250 255 Val Gln Lys Gly Leu Gln Leu Asp Tyr Arg Thr Gly Glu Val Thr Val 260 265 270 Thr Gln 169 225 DNA Streptococcus pneumoniae 169 gtgctaagat tcagcggatt gaggcaagtg atgaagatga ataagaaatc aagctacgta 60 gtcaagcgtt tacttttagt catcatagta ctgattttag gtactctggc tctaggaatc 120 ggtttaatgg taggttatgg aatcttgggc aagggtcaag atccatgggc tatcctgtct 180 ccagcaaaat ggcaggaatt gattcataaa tttacaggaa attag 225 170 74 PRT Streptococcus pneumoniae 170 Val Leu Arg Phe Ser Gly Leu Arg Gln Val Met Lys Met Asn Lys Lys 1 5 10 15 Ser Ser Tyr Val Val Lys Arg Leu Leu Leu Val Ile Ile Val Leu Ile 20 25 30 Leu Gly Thr Leu Ala Leu Gly Ile Gly Leu Met Val Gly Tyr Gly Ile 35 40 45 Leu Gly Lys Gly Gln Asp Pro Trp Ala Ile Leu Ser Pro Ala Lys Trp 50 55 60 Gln Glu Leu Ile His Lys Phe Thr Gly Asn 65 70 171 40 DNA Artificial Sequence Description of Artificial Sequence Primer 171 cgagatctga tatctcacaa acagataacg gcgtaaatag 40 172 43 DNA Artificial Sequence Description of Artificial Sequence Primer 172 gaagatcttc cccgggatca caaacagata acggcgtaaa tag 43 173 42 DNA Artificial Sequence Description of Artificial Sequence Primer 173 cgagatctga tatccatcac aaacagataa cggcgtaaat ag 42 174 32 DNA Artificial Sequence Description of Artificial Sequence Primer 174 cgggatcctt atggacctga atcagcgttg tc 32 175 23 DNA Artificial Sequence Description of Artificial Sequence Primer 175 ggatgctttg tttcaggtgt atc 23 176 82 DNA Artificial Sequence Description of Artificial Sequence Primer 176 catgatatcg gtacctcaag ctcatatcat tgtccggcaa tggtgtgggc tttttttgtt 60 ttagcggata acaatttcac ac 82 177 81 DNA Artificial Sequence Description of Artificial Sequence Primer 177 gcggatcccc cgggcttaat taatgtttaa acactagtcg aagatctcgc gaattctcct 60 gtgtgaaatt gttatccgct a 81 178 24 DNA Artificial Sequence Description of Artificial Sequence Primer 178 cgccagggtt ttcccagtca cgac 24 179 20 DNA Artificial Sequence Description of Artificial Sequence Primer 179 tcaggggggc ggagcctatg 20 180 22 DNA Artificial Sequence Description of Artificial Sequence Primer 180 tcgtatgttg tgtggaattg tg 22 181 26 DNA Artificial Sequence Description of Artificial Sequence Primer 181 tccggctcgt atgttgtgtg gaattg 26 182 5 PRT Artificial Sequence SITE (3) Xaa=Any amino acid 182 Leu Pro Xaa Thr Gly 1 5 183 18 DNA Artificial Sequence Description of Artificial Sequence Primer 183 gcgggatccg ccaccatg 18 184 10 DNA Artificial Sequence Description of Artificial Sequence Primer 184 ttgcggccgc 10 185 43 DNA Artificial Sequence Description of Artificial Sequence Primer 185 cggatccgcc accatgggtc taattgaaga cttaaaaaat caa 43 186 36 DNA Artificial Sequence Description of Artificial Sequence Primer 186 ttgcggccgc caatgctaga ctaaacacaa gactca 36 187 36 DNA Artificial Sequence Description of Artificial Sequence Primer 187 cgcggatcca tgaaaaaaat ctattcattt ttagca 36 188 38 DNA Artificial Sequence Description of Artificial Sequence Primer 188 ccctcgaggg ctacttccga tacattttaa actgtagg 38 189 35 DNA Artificial Sequence Description of Artificial Sequence Primer 189 cggatccgcc accatgagtc atgtcgctgc aaatg 35 190 32 DNA Artificial Sequence Description of Artificial Sequence Primer 190 ttgcggccgc ataccaaacg ctgacatcta cg 32 191 38 DNA Artificial Sequence Description of Artificial Sequence Primer 191 cggatccgcc accatgcaaa aagagcggta tggttatg 38 192 30 DNA Artificial Sequence Description of Artificial Sequence Primer 192 ttgcggccgc acccccattc ttaatccctt 30 193 40 DNA Artificial Sequence Description of Artificial Sequence Primer 193 cggatccgcc accatggagg tatgtgaaat gtcacgtaaa 40 194 32 DNA Artificial Sequence Description of Artificial Sequence Primer 194 ttgcggccgc ttttacaaag tcaagcaaag cc 32 195 48 PRT Streptococcus pneumoniae 195 Gly Ile Arg Leu Arg Asn Met Leu Phe Lys Ile Trp Pro Ala Val Ala 1 5 10 15 Leu Val Thr Ser Ser Gly Asn Asn Val Ser Met Leu His Ser Ile Ala 20 25 30 Asn Met Gly Gln Leu Thr Leu Gly Thr Gln Cys Gln Thr Val Val Val 35 40 45 196 11 PRT Streptococcus pneumoniae 196 Gln Lys Ile Thr Met Ile Thr Phe Thr Phe Gln 1 5 10

Claims

1. A Streptococcus pneumoniae protein or polypeptide having a sequence selected from those shown in table 1.

2. A Streptococcus pneumoniae protein or polypeptide having a sequence selected from those shown in table 2.

3. A protein or polypeptide as claimed in claim 1 or claim 2 provided in substantially pure form.

4. A protein or polypeptide which is substantially identical to one defined in any one of claims 1 to 3.

5. A homologue or derivative of a protein or polypeptide as defined in any one of claims 1 to 4.

6. An antigenic and/or immunogenic fragment of a protein or polypeptide as defined in Tables 1-3.

7. A nucleic acid molecule comprising or consisting of a sequence which is:

(i) any of the DNA sequences set out in Table 1 or their RNA equivalents;

(ii) a sequence which is complementary to any of the sequences of (i);

(iv) a sequence which is substantially identical with any of those of (i), (ii) and (iii);

8. A nucleic acid molecule comprising or consisting of a sequence which is:

(i) any of the DNA sequences set out in Table 2 or their RNA equivalents;

(ii) a sequence which is complementary to any of the sequences of (i);

9. The use of a protein or polypeptide having a sequence selected from those shown in Tables 1-3, or homologues, derivatives and/or fragments thereof, as an immunogen and/or antigen.

10. An immunogenic and/or antigenic composition comprising one or more proteins or polypeptides selected from those whose sequences are shown in Tables 1-3, or homologues or derivatives thereof, and/or fragments of any of these.

11. An immunogenic and/or antigenic composition as claimed in claim 10 which is a vaccine or is for use in a diagnostic assay.

12. A vaccine as claimed in claim 11 which comprises one or more additional components selected from excipients, diluents, adjuvants or the like.

13. A vaccine composition comprising one or more nucleic acid sequences as defined in Tables 1-3.

14. A method for the detection/diagnosis of S. pneumoniae which comprises the step of bringing into contact a sample to be tested with at least one protein or polypeptide as defined in Tables 1-3, or homologue, derivative or fragment thereof.

15. An antibody capable of binding to a protein or polypeptide as defined in Tables 1-3, or for a homologue, derivative or fragment thereof.

16. An antibody as defined in claim 15 which is a monoclonal antibody.

17. A method for the detection/diagnosis of S. pneumoniae which comprises the step of bringing into contact a sample to be tested and at least one antibody as define din claim 15 or claim 16.

18. A method for the detection/diagnosis of S. pneumoniae which comprises the step of bringing into contact a sample to be tested with at least one nucleic acid sequence as defined in claim 7 or claim 8.

19. A method of determining whether a protein or polypeptide as defined in Tables 1-3 represents a potential anti-microbial target which comprises inactivating said protein or polypeptide and determining whether S. pneumoniae is still viable.

20. The use of an agent capable of antagonising, inhibiting or otherwise interfering with the function or expression of a protein or polypeptide as defined in Tables 1-3 in the manufacture of a medicament for use in-the treatment or prophylaxis of S. pneumoniae infection