TWI815335B - Rinsing cleaning composition mild to skin including supersaturated active ingredients, use thereof, and the production method for the same - Google Patents

Abstract

The present invention provides a rinsing cleaning composition mild to skin including near saturated, saturated, or supersaturated active ingredients, which comprises at least one surface active agent and at least one active ingredient. The composition simultaneously cleans skin and improves morphology and performance of skin, for example, enhanced gloss and anti-wrinkle.

Description

Mild cleansing compositions containing supersaturated active ingredients and their uses and preparation methods

The present invention relates to a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients and a preparation method thereof, and in particular to a mild cleansing composition containing at least one surfactant and at least one nearly saturated, saturated, or supersaturated active ingredient that can be Cleansing and care composition with active ingredients for improving skin texture and preparation method thereof.

Skin is the largest natural barrier between the human body and the outside world. In order to keep the skin in a good hygienic state (that is, clean and healthy), the goal of skin cleaning is to remove foreign objects in the human body's environment and the sebum and sweat produced by the human body itself. , so skin cleansing is the primary step to maintain skin health. Take facial cleansing as an example. After washing your face with general cleaning products, it is easy to not wash your face thoroughly, causing pores to be clogged or excessive cleaning to cause damage to the skin's natural barrier (Indian J Dermatol. 2011 Jan-Feb; 56(1): 2 -6); The water temperature, time, selection of cleaning products, and cleaning methods of face washing all affect the cleaning efficiency and the maintenance of skin function. How to completely clean and maintain the normal function of the skin at the same time, and even increase the aesthetic level of the skin? That is what relevant researchers find difficult to break through.

The cleaning principles of detergents can be roughly divided into two types: dissolving and emulsifying dirt (Physicochemical and Engineering Aspects, 74, 169-215 (1993)). Cleansers used to remove dirt using the principle of dissolution are difficult to avoid excessive cleaning of the skin surface, thus damaging the skin barrier. It will cause rough and dry skin after cleansing (Clinics in Dermatology, Volume 14, Issue 1, January-February 1996, Pages 29-33), or even lead to excessive secretion of sebum; detergents used to remove dirt using the principle of emulsification, Emulsifiers are not easy to completely remove dirt, leaving a small amount of micro-emulsified droplets that have not been washed away to accumulate on the skin surface, pores, and sweat glands, resulting in an unclean feeling, clogged pores, and acne proliferation.

In addition, the timing and method of skin care after cleansing are also a challenge in ordinary people's lives. The timing of personal skin care varies from person to person, but the evaluation of skin care products can be analyzed from two aspects: First, the formula combination of skin care products mainly includes water, oil, emulsifiers, stabilizers, various bases and even solvents, etc. Since the basic composition It becomes two immiscible oil and water phases with the largest composition ratio. Therefore, emulsifiers, stabilizers, etc. are needed. If it needs to be combined with other active ingredients, it often faces various challenges in terms of physical and chemical stability, and the active ingredients occupy The ratio is usually quite low, making it difficult to achieve improvements in aesthetic or clinical effects; secondly, the absorption of topical skin preparations mainly depends on the barrier formed by the stratum corneum, resulting in limited effects. Whether it is a transdermal delivery system (TDDS) for drugs or cosmetics, there are generally two ways: 1. Direct penetration of the stratum corneum, or penetration through the lipid bilayer in the keratinocyte space. The main route through the skin; 2. Through skin appendages such as hair follicles, sebaceous glands or sweat glands, which only account for 0.1 to 1.0% of the skin, so a very small amount of active ingredients are absorbed through this route). The problems that need to be overcome in the first absorption method mainly include the acid mantle of the skin (Current Pharmaceutical Design, 2015, Vol. 21, No. 00) and the stratum corneum that causes absorption obstacles, both of which are barriers to drugs and cosmetics. The main obstacle to the absorption of active ingredients is also the main factor that makes it difficult for consumers to achieve the expected maintenance effects when using various skin care products.

To sum up, the present invention aims to provide a mild cleansing composition and method that solves the problem of cleaning and maintenance at the same time, and all literature and patent documents cited in this article are by reference. Incorporated into this case.

In view of the shortcomings of the existing cleaning and maintenance technology, the present invention aims to improve the previous technology, which is difficult to clean the skin with a gentle formula and maintain the skin in a suitable way, so as to simultaneously clean the skin, prevent over-cleaning, and at the same time achieve preliminary maintenance effects to enhance skin function. Gentle cleansing composition. The present invention combines the active ingredients with a mild surfactant formula in a nearly saturated, saturated or super-saturated manner, and uses a simple process to produce a composition that can simultaneously cleanse, avoid excessive cleansing and maintain the skin, in which the active ingredients include Angelica dahurica. (J Cosmet Sci. 2006 Jan-Feb; 57(1): 11-21), Bletilla (Ann Dermatol Vol. 28, No. 3, 2016), Atractylodes (Journal of Ethnopharmacology Volume 226, 15 November 2018, Pages 143 -167), Bletilla (Fitoterapia Volume 92, January 2014, Pages 72-78), Poria (Planta Medica 77(7): 681-91.February 2011), Aconite (American Journal of Phytomedicine and Clinical Therapeutics, 2014, Pages 1277 -1286), or one or more extracts of Lithospermum (Experimental Dermatology, 2018 Sep; 27(9): 1043-1047); and surfactants include long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl One or more combinations of methyl isethionate or potassium cocoyl glycinate. The mild cleansing composition containing active ingredients of the present invention can be used on any skin part of the human body to directly clean the skin and achieve maintenance effects at the same time. Its effect on the skin can be one of the following or a combination thereof, such as: whitening, promoting collagen Protein synthesis, anti-inflammation, preventing skin dryness, anti-itching, anti-allergy, anti-aging, antioxidant, immune regulation, anti-fibrosis, etc.

According to the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients according to the present invention, the individual active ingredients are iconic and representative ingredients cited in the composition of the present invention (especially those that are fat-soluble and have high physiological activity). substance), the aqueous solution saturations are respectively: Angelica dahurica ≦0.01%, Dahurica dahurica ≦0.003%, Atractylodes ≦0.004%, Bletilla ≦0.006%, Poria ≦0.05%, Aconite ≦0.0002%, Lithospermum ≦0.01%; therefore, its total saturated concentration is approximately no more than 0.1%.

The active ingredient extraction and preparation method of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients can be any of the general high-temperature aqueous solution extraction method, organic solvent extraction method, ultrasonic extraction method, or supercritical fluid extraction method. One or more extraction combinations.

The active ingredients of this mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients can meet the definitions of cosmetics and drugs at the same time according to the US Food and Drug Administration Cosmetics Laws & Regulations. It means that the invention according to scientific journals and the intended purpose of use is any ingredient that has any function that can affect humans or other animals; and is used for human body cleaning, beauty, etc.

Preferably, the active ingredients of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients are intended to be used for rubbing, pouring, spraying or sprinkling, introducing or wiping into the human body for cleaning, beautifying, and improving tightness. A substance that modifies or changes its appearance.

More preferably, the active ingredients of this mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients mean that its effect on the skin can be one of the following or a combination thereof, such as: whitening, promoting collagen synthesis , anti-inflammation, avoid dry skin, relieve itching, anti-allergy, anti-aging, antioxidant, immune regulation, anti-fibrosis, etc.

The mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients has O/W microemulsions (American Journal of Pharmtech Research, 2012), emulsions, or micelles (Cancers, July) depending on its different formula combinations. 2018) and other different dosage forms.

In the field of pharmacology, it is often necessary to maximize the active ingredients in dosage form design, especially liquid dosage forms containing fat-soluble and highly physiologically active drugs, such as paclitaxel, paclitaxel, European paclitaxel and other drugs, which require effective treatment. Dosage, minimize the total volume of activity administered Ingredients are designed to be as close as possible to the dissolution saturation of the active ingredients; on the contrary, due to the near-saturated, saturated, and supersaturated characteristics of the active ingredients, it causes the disadvantage of easy precipitation after mixing with water. The present invention utilizes the nearly saturated, saturated, and supersaturated characteristics of active ingredients to convert this shortcoming into the advantages of external preparations. After mixing with water, the active ingredients can be separated and absorbed to avoid being dissolved and washed out by detergents. It further cooperates with the hydration effect of cleansers on the skin to increase the absorption and effect of active ingredients.

Skin dirt and acidic barriers can be removed through cleansing to increase the absorption of active ingredients. However, the penetration of the stratum corneum requires the design of a cosmeceutical delivery system to overcome the direct contact between keratinocytes and keratinocytes. Barriers to penetration (Skin Pharmacol Physiol 2006:19:106-21). The present invention uses a mild surfactant combination. This surfactant combination mainly uses the principle of emulsification method to clean the skin and produce the hydration phenomenon of the stratum corneum. In this state, the stratum corneum not only increases Penetration also increases the capacity (Capacitance) between the stratum corneum. The present invention utilizes this hydration phenomenon to increase the adhesion and penetration of the active ingredients into the stratum corneum at the appropriate time (The Journal of Investigative Dermatology, Vol. 101, No. 3 , September 1993); at the same time, the phenomenon that the concentration of active ingredients is close to saturation, saturation, or supersaturation (Pharmaceutical Research, July 2001, Volume 18, Issue 7, pp 1006-1011) is used to facilitate the deposition, adhesion and absorption of active ingredients through concentration differences. This produces a protective and maintenance effect on the skin, and because of this novel design principle, it can also eliminate the possibility of over-cleansing the skin.

Long-chain betaines (Handbook for Cleaning/Decontamination of Surfaces), sodium lauroyl sarcosinate (Cosmetic Ingredient Review, September 2016), sodium lauroyl methyl isethionate (Cosmetic Ingredient Review, September 2013) and potassium cocoyl glycinate (Cosmetic Ingredient Review, September 2013) Demonstrated in various studies and scientific literature as a mild, low-irritation interface for skin and eyes Active agent, this mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients is invented. This mild and clean surfactant combination is used to gently cleanse the skin, and secondly to dissolve the active ingredients until they are close to saturation. , saturated, or super-saturated concentration, achieving the effects of cleansing and maintaining skin at the same time.

In order to achieve the above-mentioned purpose of cleaning, avoiding excessive cleansing and maintaining skin at the same time, the present invention provides a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients, which includes at least one surfactant and at least one nearly saturated, A cleansing and care composition containing saturated or supersaturated active ingredients that can improve skin texture and a preparation method thereof. The surfactant is any combination of one or more of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate and accounts for 5.00wt% to 70.00wt% of the composition of the invention; the active ingredient is composed of Angelica dahuricae. , Bletilla, Atractylodes, Bletilla, Poria, Aconite, or Lithospermum any combination of one or more extracts and accounting for 0.1wt% to 10.00wt% of the inventive composition; the inventive composition may further include an appropriate amount of water, It accounts for 15.00wt% to 85.00wt% of the composition of the invention; the composition of the invention may further contain an appropriate amount of cosmetic excipients, such as diluents, thickeners, stabilizers, flavors, preservatives, and cosurfactants. ) and so on, the excipient accounts for 0wt% to 15.00wt% of the composition of the invention.

Preferably, the surfactant long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate of the inventive composition accounts for 0wt% to 25.00wt% and 0wt% to 20.00wt of the inventive composition respectively. %, 0wt% to 25.00wt%, 0wt% to 20.00wt%, and their sum cannot be zero.

More preferably, the surfactant of the composition of the invention is any combination of one or more of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate and accounts for 10.00wt% to 65.00% of the composition of the invention. wt%.

Optimally, the surfactant of the composition of the invention consists of long-chain betaines, sodium Any combination of one or more of lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate and accounts for 20.00wt% to 60.00wt% of the composition of the invention.

Preferably, the active ingredients of the composition of the invention are Angelica dahurica dahurica, Atractylodes atractylodes, Atractylodes macrocephala, Bletilla striata, Poria cocos, aconite, or Lithospermaceae, accounting for 0wt% to 8.00wt%, 0wt% to 8.00wt%, and 0wt of the inventive composition respectively. % to 8.00wt%, 0wt% to 4.00wt%, 0wt% to 4.00wt%, 0wt% to 4.00wt%, 0wt% to 4.00wt%, and the sum thereof shall not be zero.

Preferably, the active ingredient of the inventive composition is any combination of one or more of Angelica dahurica, Bletilla, Atractylodes, Bletilla, Poria, Aconite, or Lithospermum and accounts for 0.10wt% to 8.00wt% of the inventive composition.

More preferably, the active ingredient of the composition of the invention is any combination of one or more of Angelicae dahuricae, Bacteria, Atractylodes, Bletilla, Poria, Aconite, or Lithospermum and accounts for 0.20wt% to 6.00wt% of the composition of the invention.

Optimally, the active ingredient of the composition of the invention is any combination of one or more of Angelica dahurica, Bletilla, Atractylodes, Bletilla, Poria, Aconite, or Lithospermum and accounts for 0.40wt% to 4.00wt% of the composition of the invention.

Preferably, the inventive composition may further comprise an appropriate amount of water, accounting for 20.00wt% to 80.00wt% of the inventive composition. More preferably, it accounts for 25.00wt% to 75.00wt% of the composition of the invention. Optimally, it accounts for 30.00wt% to 70.00wt% of the composition of the invention.

Preferably, the composition of the invention may further comprise an appropriate amount of cosmetic excipients, which may be diluents, thickeners, stabilizers, fragrances, preservatives, or cosurfactants, etc., and the Excipients comprise 0.50wt% to 10.00wt% of the composition of the invention. Preferably, the excipient accounts for 1.00% to 8.00% by weight of the composition of the invention. More preferably, the excipient accounts for the hair The composition may range from 2.00% to 6.00% by weight. Optimally, the excipient accounts for 4.00% to 6.00% by weight of the composition of the invention.

The invention provides a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients, which includes at least one surfactant and at least one nearly saturated, saturated, or supersaturated active ingredient that can improve skin texture. Composition, wherein the mild cleansing composition is prepared by the following preparation method, the preparation method includes the following steps: (i) adding the at least one active ingredient into a mixing container and adding an appropriate amount of water; and (ii) adding the at least one active ingredient to a mixing container and adding an appropriate amount of water; At least one surfactant is added to the mixing container in step (i) and mixed evenly, and if necessary, heated until dissolved and mixed evenly; (iii) If necessary, add appropriate excipients, such as diluents, thickeners, stabilizers, Flavoring agents, or preservatives, etc., continue to mix evenly and return to room temperature.

According to the present invention, preferably, the active ingredients of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients and its preparation method can be extracted by general high-temperature aqueous solution extraction, organic solvent extraction, or ultrasonic extraction. , or any extraction combination of one or more of supercritical fluid extraction methods.

In order to make the above-mentioned features and advantages of the present invention more obvious and easy to understand, embodiments are given below and described in detail with reference to the accompanying drawings.

Figure 1 is a schematic diagram illustrating that the present invention uses surfactants and water to hydrate the stratum corneum, and that the active ingredients are implemented in a nearly saturated, saturated, or supersaturated form to facilitate skin absorption.

Figure 2 is a series of microscopic photos magnified at different magnifications, showing the precipitation state of Example 12 of the composition of the present invention before being mixed with water.

Figure 3 is a series of microscopic photos magnified at different magnifications, showing the sedimentation state at a time point of 10 minutes after the composition of Example 12 of the present invention and water were evenly mixed with water in a weight ratio of 1:1.

Figure 4 is a series of microscopic photos magnified at different magnifications, showing the sedimentation state at 60 minutes after the composition of Example 12 of the present invention and water were evenly mixed with water in a weight ratio of 1:1.

Figure 5 is a series of micrographs magnified at different magnifications, showing the precipitation state of Example 12 of the composition of the present invention and water at a time point of 360 minutes after they were evenly mixed with water in a weight ratio of 1:1.

Figure 6 is a series of microscopic photos magnified at different magnifications, showing the sedimentation state at the time point of 720 minutes after the composition of Example 12 of the present invention and water were evenly mixed with water in a weight ratio of 1:1.

Figure 7 is a 200x magnified microscope photograph showing the state of the skin before cleaning with general cleansers.

Figure 8 is a 200-fold magnified micrograph showing the state of the skin before cleaning according to Example 10 of the composition of the present invention.

Figure 9 is a 30x magnified microscope photograph showing the state of the skin after being continuously washed with general cleansers for 20 times.

Figure 10 is a 30 times magnified microscope photograph showing the state of the skin after being continuously cleaned for 20 times according to Example 10 of the composition of the present invention.

Figure 11 is a 200x magnification micrograph showing the state of the skin after being washed with a general cleanser for 20 times.

Figure 12 is a 200x magnified micrograph showing the state of the skin after being continuously cleaned for 20 times using Example 10 of the composition of the present invention.

Figure 13 is a moisturizing degree detection chart, illustrating the moisturizing degree of the skin immediately after cleansing and 10 minutes after cleansing according to Example 11 of the composition of the present invention.

Figure 14 is a glossiness detection chart, illustrating the skin immediately after cleaning and after cleaning 10 according to Example 11 of the composition of the present invention. minutes of gloss.

Figure 15 is a series of microscopic photos magnified at different magnifications, showing the precipitation state of Comparative Example 13 of the composition of the present invention and water at a weight ratio of 1:1 after being evenly mixed at a time point of 10 minutes.

Figure 16 is a series of microscopic photos magnified at different magnifications, showing the precipitation state at 60 minutes after the composition of Comparative Example 13 of the present invention and water were evenly mixed with water in a weight ratio of 1:1.

Figure 17 is a 30 times magnified micrograph showing the state of the skin before cleaning according to Comparative Example 13 of the composition of the present invention.

Figure 18 is a 30 times magnified micrograph showing the state of the skin after being continuously washed 20 times in Comparative Example 13 of the composition of the present invention.

Figure 19 is a 200x magnified micrograph showing the state of the skin before cleaning according to Comparative Example 13 of the composition of the present invention.

Figure 20 is a 200x magnified micrograph showing the state of the skin after being continuously washed 20 times in Comparative Example 13 of the composition of the present invention.

In order to clean the skin at the same time, prevent over-cleansing, and achieve preliminary maintenance effects to enhance skin function, the present invention provides a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients. The composition contains one or more Active ingredients; and one or more surfactants; the inventive composition may further include an appropriate amount of water; the inventive composition may further include an appropriate amount of cosmetic excipients.

Please refer to Figure 1 to illustrate that the present invention utilizes surfactants and water to hydrate the stratum corneum, and that the active ingredients are implemented in a nearly saturated, saturated, or supersaturated form in the combination of the present invention, so that the active ingredients are easy to precipitate on the surface of the stratum corneum. Conducive to the absorption of active ingredients.

The following examples serve to illustrate the invention. These examples are not intended to limit the scope of the invention in any way, but are intended to be indicative of how to practice the materials and methods of the invention.

In the embodiment of the present invention, the so-called having at least one surfactant is a composition selected from long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate, one or any combination thereof.

In the embodiments of the present invention, the so-called having at least one active ingredient is a composition selected from the extracts of Angelica dahurica, Bletilla, Atractylodes, Bletilla, Poria, Aconite, or Lithospermum, one or more of the above, or any combination thereof.

Example 1: Mild cleansing composition formulation 1 containing active ingredients and method of making the same

In this example, every 1000 grams of the final product contains the equivalent of 5 grams of active ingredients. The manufacturing method is as follows: each active ingredient is extracted with a mixed extraction solution of equal weight proportions of alcohol and water, wherein the mixed extract solution and each active ingredient The weight ratio of the ingredients is 10:1 to 50:1, the extraction temperature is 50 to 100°C, and the extraction time is 1 hour to 10 hours. The extracted content contains 1000 mg each of Angelica dahuricae, Bletilla chinensis, and Atractylodes rhizome, and Bletilla striata, 500 mg each of the extracts of Poria, Aconite, and Lithospermum, and mix with 50 g each of cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, and potassium cocoyl glycinate with an appropriate amount of water. If necessary, heat until homogeneous and add PEG-7 glyceryl. Mix 10 grams each of cocoate and PEG-200 hydrogenated glyceryl palmate evenly, then add 10 grams of sodium chloride, stir and mix until uniform, and cool to room temperature. Table 1 is the composition of the formula of Example 1.

Table 1, Example 1 formula composition composition table

Embodiments 2 to 12: Formulas 2 to 12 of mild cleansing compositions containing active ingredients. The manufacturing method is similar to that of Embodiment 1, but the different formula compositions and extraction methods are also shown in Table 2. Table 2 is Embodiments 1 to 12. Formula composition composition table, Table 3 shows the extraction methods of active ingredients of the formula compositions of Examples 1 to 12, Table 4 shows the extraction conditions of each extraction method.

Table 3. Extraction methods of active ingredients of the formulations of Examples 1 to 12

The present invention provides a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients. The test results are as follows: <Nearly saturated, saturated, or supersaturated test>

Microscopically, observe the composition of the present invention Example 12 with a microscope. In addition, mix water and the composition of the present invention in a weight ratio of 1:1. Observe with a microscope at time points of 10, 60, 360, and 720 minutes. The saturated sedimentation situation is shown in Figures 2 to 6. The results showed that no precipitation occurred in the composition of the present invention (Figure 2); water and the composition of the present invention were mixed evenly at a weight ratio of 1:1, and a trace amount of precipitate visible under an optical microscope was produced at 10 minutes (Figure 3 ), a small amount of precipitate is produced at 60 minutes (Figure 4), agglomerated precipitate is produced at 360 minutes (Figure 5), and a large amount of precipitate is produced at 720 minutes (Figure 6); on the contrary, the critical saturation experiment is generally observed from a macro perspective. The stability test is performed. Due to the decrease in energy, agglutination will slowly occur after long-term storage. This test shows the excellent design of the composition of the present invention near the saturation critical value (Journal of Pharmaceutical Sciences, January 2012); proving this Under the concept of "Quality by Design", the composition of the invention is sufficient to protect and maintain the skin when it actually cleanses the skin.

〈Avoid excessive cleaning and protection of experiments〉

The inner thighs were cleaned, dried and washed again using commercially available cleaning products (Dermisa Brightening Bar) and the composition Example 10 of the present invention for 20 consecutive cleaning procedures. The results are as shown in Table 5 and Figures 7 to 12. Avoid excessive cleaning. Experimentally shown.

The experiment used glossiness and microscopic examination as observation tools to simulate general washing methods for cleaning. The results showed that the skin surface was damaged after repeated cleaning with general detergents in a short period of time. The microscopic examination results also showed that the stratum corneum was damaged and white peeled off. Flaky or even rolled up, this microscopic result of microscopic examination also showed a decrease in the macroscopic gloss test results; on the contrary, after repeated cleaning with the composition of the present invention in a short period of time, the skin surface was not only free of damage , the difference between before and after cleaning cannot be distinguished by observing the microscopic examination results, but the improvement of skin smoothness can be seen from the glossiness results. Based on this, it can be expected that long-term use of the composition of the present invention will make the skin more delicate and smooth, further leading to glossiness. Significantly improved to the point where the human eye can discern the difference.

In summary, based on the prior art and general knowledge and cognition, using cleansers to clean the skin can easily damage the stratum corneum and cause the skin surface to be rough, and then use creams and other skin care products on the damaged skin. In contrast, the composition of the present invention utilizes close to Saturated, saturated, or supersaturated designs make effective The ingredients can be precipitated, absorbed and protected from damage during the cleansing process.

〈Moisture Level Experiment〉

In Example 11, the standard steps are one decontamination and one cleansing each time you wash your face. After each cleansing, measure it with a commercially available skin detector (RUNVE Skin Analyzer). This detector contains three measurement values: moisture content and oil content. The oil content and fine roughness can be combined with the skin gloss test; the moisture content is expressed by the average of the three points of the forehead and left and right bone measurements. After about 3 weeks of cleaning and testing with general facial cleansing products (Dermisa Brightening Bar), and then using the composition of the present invention to cleanse the skin in accordance with the above standard usage steps for more than 4 weeks, it can be seen from the moisture content testing chart (Figure 13) Whether it was just after cleansing or 10 minutes after cleansing, the moisturizing index showed a significant improvement after two weeks.

Generally, the moisturizing degree of facial cleansing products after cleansing is between 40 and 42, and the moisturizing degree after drying is between 34 and 38. As shown in Table 6, refer to the classification of moisturizing degree in the instruction manual. It can be seen that after cleaning, it falls into the normal skin range. 10 minutes Moisture is lost to the dry skin range; in contrast, after using the composition of the present invention for about two weeks, its moisturizing degree after cleansing is between about 43 and 48, and after drying, its moisturizing degree is between about 38 and 44, refer to the skin detector According to the classification of moisturizing degree in the instruction manual, it can be seen that after cleansing, it falls into the range of suitable humidity for skin, and the moisture dissipates to the range of normal skin in 10 minutes.

〈Glossiness Experiment〉

Generally, dermatologists understand skin gloss as the oil and ring secreted by sebaceous glands. The adhesion of other substances in the environment causes an increase in skin gloss (Biomedical Optics Express). This environment on the skin can easily lead to the occurrence of skin diseases such as acne, seborrheic dermatitis, etc.; in contrast, when the skin is completed After cleansing without interference from the above-mentioned sebum, the skin still shows obvious luster due to long-term healthy skin composition, such as reduced skin roughness (Skin Research and Technology), reduced wrinkles, and better moisturizing. The expression of healthy skin, which may be promoted by, for example, epidermal growth factors or collagen proliferation (WO2005037270A1). Since the composition of the present invention is rich in active ingredients, it can make the skin healthier, reduce wrinkles, etc. and increase the gloss of the skin after cleansing (International Journal of Research in Pharmacy and Chemistry).

The standard procedure is to remove dirt and cleanse once every time you wash your face. After cleansing every day, use a gloss meter (BYK Micro-Gloss) to measure the skin gloss on the forehead, the flattest area of the face. After about 3 weeks of cleaning and testing with general facial cleansing products (Dermisa Brightening Bar), and then using the composition of the present invention to cleanse the skin according to the above standard usage steps for more than 4 weeks, it can be seen from the gloss test chart (Figure 14) after cleaning. Regardless of whether it was just after cleaning or 10 minutes after cleaning, the gloss index showed a significant improvement after two weeks.

Generally, the glossiness of a person's face containing sebum is about 2GU (Gloss unit). It will drop to about 1GU after cleansing or as the skin becomes rougher, and it will increase to 2.5GU as the skin becomes finer or the skin care cosmetics are used. (Optical Review). The composition of the present invention can reach a glossiness of about 3GU to 5GU after long-term use and before using various skin care products, and the glossiness difference can be discerned by the human eye (the difference that the human eye can discern is about 3GU). Therefore, it is generally Users can also clearly feel the refinement of their skin and see an increase in radiance. Since the hydrated skin after cleansing has not yet dried and the stratum corneum has not returned to its original state, the gloss level falls around 3GU. After 10 minutes of recovery, the gloss level can normally appear to be around 5GU.

Comparative Example 13: Mild cleansing composition formulation 13 containing unsaturated active ingredients and its manufacturing method

This comparative example contains an active ingredient equivalent to 0.83 grams per 1000 grams. The manufacturing method is as follows: Extract with alcohol and water in equal proportions, containing 100 mg each of Angelica dahuricae, Atractylodes atractylodes, and Atractylodes rhizome, as well as Bletilla striata and Poria cocos. , 50 mg each of aconite and Lithospermum extract, and mix with 50 g each of cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, potassium cocoyl glycinate and an appropriate amount of water. If necessary, heat to a uniform state and add PEG-7 glyceryl cocoate. , 10 grams each of PEG-200 hydrogenated glyceryl palmate, mix evenly, then add 10 grams of sodium chloride, stir and mix until uniform, and cool to room temperature to obtain. Table 7 is a composition table of the formula composition of Comparative Example 13.

This comparative example provides a mild cleansing composition containing unsaturated active ingredients. The results of various comparative tests are as follows: 〈Close to saturation, saturation, super saturation test〉

Microscopically, mix Comparative Example 13 and water in equal proportions by weight. Observe with a microscope at 10 and 60 minutes to check whether there is precipitation due to unsaturation, as shown in Figures 15 and 16. The results show that no precipitation occurred in this unsaturated comparative example 13.

〈Avoid excessive cleaning and protection comparison experiment〉

In Comparative Example 13, the inner thighs were washed, dried, and washed for 20 consecutive times. The results are shown in Table 8 and Figures 17 to 20 in the comparative experiment to avoid over-cleaning.

The experiment used glossiness and microscopy as observation tools to simulate general washing methods for cleaning. The results showed that the skin surface of Comparative Example 13 did not change significantly after repeated cleaning in a short period of time; although the glossiness results (before cleaning) 1.4GU, 1.4GU after cleaning), there is no obvious change in the smoothness of the skin, and the microscopic examination results cannot reveal the significant difference in cell types before and after cleaning, but under the microscope: the gloss after cleaning is still better than before cleaning reduce.

Based on the experimental results of comparing saturated Example 10 and unsaturated Example 13 to avoid excessive cleansing and protecting the skin, the saturated Example 10 not only has the function of avoiding excessive cleaning and protecting the skin, but also can increase the smoothness of the skin; conversely, it does not Saturated Example 13 is not significant in preventing over-cleansing and protecting the skin. This experiment shows that the invention of a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients has its special novelty and advancement.

Although the present invention has been disclosed above through embodiments, they are not intended to limit the present invention. Anyone with ordinary knowledge in the relevant technical field can make some modifications without departing from the spirit and scope of the present invention. Modifications and modifications are allowed, so the scope of protection of the present invention shall be determined by the appended patent application scope.

Claims (9)

A mild cleansing composition comprising: at least one surfactant selected from the group consisting of long-chain betaines, sodium lauroyl sarcosinate, and lauryl hydroxymethylethanesulfonic acid. At least two of sodium lauroyl methyl isethionate and potassium cocoyl glycinate, and the surfactant accounts for 10wt% to 65wt% of the mild cleansing composition; and at least one supersaturated and skin-improving agent The active ingredients of the texture include 0.10 to 1.80wt% of Angelica dahuricae extract, 0.10 to 1.80wt% of Bletilla striata extract, 0.10 to 1.80wt% of Atractylodes rhizome extract, 0.05 to 0.80wt% of Bletilla striata extract, 0.05 to 0.05 to 1.80wt% of Bletilla striata extract. At least two of 0.80wt% Poria cocos extract, 0.05 to 0.80wt% Aconite extract and 0.05 to 0.20wt% Comfrey extract, wherein the active ingredient accounts for 0.2wt% to 6wt of the mild cleansing composition %. The mild cleansing composition of claim 1, wherein the surfactant includes 5.0 to 20.0wt% long-chain betaines and 5.0 to 20.0wt% sodium lauroyl sarcosinate. , at least two of 5.0 to 20.0wt% sodium lauroyl methyl isethionate, and 5.0 to 20.0wt% potassium cocoyl glycinate. The mild cleansing composition as claimed in claim 1, wherein the active ingredients include 0.60 to 1.80wt% Angelica dahurica extract, 0.60 to 1.80wt% White Cortex extract, 0.60 to 1.80wt% Atractylodes extract, 0.40 to 0.80wt% At least two of Bletilla striata extract, 0.20 to 0.80 wt% Poria cocos extract, 0.20 to 0.80 wt% Fuzi extract, and 0.10 to 0.20 wt% Lithospermum extract. The mild cleansing composition as claimed in claim 1, further comprising a viscosity modifier including sodium chloride, accounting for 0.1 to 2.0 wt% of the mild cleansing composition; and at least one thickener including PEG-40 Hydrogenated castor oil, PEG-7 glyceryl cocoate, PEG-200 hydrogenated glyceryl palmitoleate, or a combination of any two thereof, wherein the at least one thickener accounts for 0.50 to 4.00 wt% of the mild cleansing composition. The mild cleansing composition of claim 4, wherein the at least one thickener includes 0.50 to 4.0 wt% PEG-40 hydrogenated castor oil, 0.05 to 1.00 wt% PEG-7 glyceryl cocoate, 0.05 to 1.00 wt% of PEG-200 hydrogenated glyceryl palmitoleate or a combination of any two thereof. The mild cleansing composition as described in claim 1 further includes an appropriate amount of water, wherein the appropriate amount of water accounts for 20wt% to 80wt% of the mild cleansing composition. The mild cleansing composition as described in claim 1 further includes an appropriate amount of cosmetic excipients, wherein the appropriate amount of cosmetic excipients accounts for 0.50wt% to 10.00wt% of the mild cleansing composition. The mild cleansing composition according to claim 1, wherein the preparation method of the extract of the active ingredient is a general high-temperature aqueous solution extraction method, an organic solvent extraction method, an ultrasonic extraction method, or a supercritical fluid extraction method. The use of the mild cleansing composition according to any one of claims 1 to 8 for preparing a composition for improving skin texture, skin protection and skin care, comprising administering an effective dose of the mild cleansing composition to the skin of the desired individual Surface; Among them, the surfactant cleans the skin and produces hydration (Hydration) of the skin stratum corneum to increase the penetration of the skin stratum corneum and the capacity (Capacitance) between the skin stratum corneum. The concentration of the active ingredient is in a super saturated state. , its deposition adheres to the skin to achieve the effects of improving skin texture, skin protection and skin care.