TWI807133B - Rinsing cleaning composition mild to skin including near saturated, saturated, or supersaturated active ingredients, and the production method for the same - Google Patents

Abstract

The present invention provides a rinsing cleaning composition mild to skin including near saturated, saturated, or supersaturated active ingredients, which comprises at least one surface active agent and at least one active ingredient. The composition simultaneously cleans skin and improves morphology and performance of skin, for example, enhanced gloss and anti-wrinkle.

Description

Mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients and method for preparing same

The present invention relates to a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients and its preparation method, and in particular to a cleansing and maintenance composition containing at least one surfactant and at least one near saturated, saturated, or supersaturated active ingredient capable of improving skin texture and its preparation method.

The skin is the largest natural barrier between the human body and the outside world. In order to keep the skin in a good hygienic state (that is, a clean and healthy state), the goal of skin cleaning is to remove foreign substances in the environment where the human body is located and the sebum and sweat produced by the human body itself. Therefore, skin cleaning is the first step in maintaining skin health. Taking facial cleansing as an example, after washing the face with general cleansing products, it is easy to fail to clean the pores, resulting in clogged pores or damage to the skin’s natural barrier due to over-cleaning (Indian J Dermatol. 2011 Jan-Feb; 56(1): 2-6); the water temperature, time, choice of cleaning products, and cleaning method of washing the face affect the cleaning performance and the maintenance of skin functions. Difficult to break through.

The cleaning principles of detergents can be roughly divided into two types: dissolving and emulsifying dirt (Physicochemical and Engineering Aspects, 74, 169-215 (1993)). It is difficult to avoid excessive cleaning of the skin surface with detergents used to remove dirt by the principle of dissolution, thus causing damage to the skin barrier and causing rough and dry skin after cleaning (Clinics in Dermatology, Volume 14, Issue 1, January-February 1996, Pages 29-33), and even lead to excessive secretion of sebum; detergents and emulsifiers used to remove dirt by the principle of emulsification are not easy to completely remove dirt, thus leaving a small amount of milk Tiny milk droplets that are not washed off after melting accumulate on the skin surface, pores, and sweat glands, resulting in an unclean feeling, clogged pores, and acne hyperplasia.

In addition, the timing and method of skin care after cleansing is also a challenge in the lives of ordinary people. The timing of personal skin care varies from person to person, but the evaluation of skin care products can be analyzed from two aspects: First, the formula combination of skin care products mainly includes water, oil, emulsifier, stabilizer, various base agents and even solvents, etc. Since the basic composition is two immiscible oil-water phases with the largest composition ratio, emulsifiers, stabilizers, etc. are required. When other active ingredients must be used, they often face various challenges in terms of physical and chemical stability. , the impact on the absorption of topical skin preparations is mainly due to the barrier formed by the stratum corneum, resulting in limited effect. Whether it is a drug or cosmetic transdermal delivery system (transdermal delivery system, TDDS), there are generally two ways: 1. Directly penetrate the stratum corneum, or penetrate through the lipid bilayer in the space of keratinocytes. The problems to be overcome in the first absorption method are mainly the acid mantle of the skin (Current Pharmaceutical Design, 2015, Vol. 21, No. 00), and the stratum corneum that causes absorption barriers, which are the main obstacles to the absorption of active ingredients of drugs and cosmetics. This is also the main factor that consumers cannot achieve the expected maintenance effect when using various skin care products.

To sum up, the present invention is to provide a mild cleansing composition and method for simultaneously solving cleaning and maintenance, and all documents and patent documents cited herein are incorporated into this case by reference.

In view of the shortcomings of the existing cleaning and maintenance technology, the present invention intends to improve the previous technology, which is difficult to clean the skin with a gentle formula and maintain the skin in a suitable way, and become a mild cleansing composition that simultaneously cleans the skin, prevents over-cleaning, and achieves the initial maintenance effect to enhance skin function. In the present invention, the active ingredient is mixed with a mild surfactant formula in a manner close to saturation, saturation or supersaturation, and a simple process is used to make a composition that can cleanse at the same time, avoid over-cleaning and maintain the skin. Ethnopharmacology Volume 226, 15 November 2018, Pages 143-167), Bletilla striata (Fitoterapia Volume 92, January 2014, Pages 72-78), Poria cocos (Planta Medica 77(7):681-91 February 2011), aconite (American Jour nal of Phytomedicine and Clinical Therapeutics, 2014, Pages 1277-1286), or comfrey (Experimental Dermatology, 2018 Sep;27(9):1043-1047); and surfactants include long-chain betaines, sodium lauroyl sarcosinate, sodium la A combination of one or more of uroyl methyl isethionate or potassium cocoyl glycinate. The mild cleansing composition containing active ingredients of the present invention can be used on any skin part of the human body to directly clean the skin and at the same time achieve maintenance effects. Its effect on the skin can be one or a combination of the following effects, such as: whitening, promoting collagen synthesis, anti-inflammation, preventing dry and cracked skin, relieving itching, anti-allergic, anti-aging, anti-oxidation, immune regulation, anti-fibrosis, etc.

According to the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients according to the present invention, the individual active ingredients cited in the composition of the present invention are iconic and representative (especially fat-soluble, highly physiologically active substances), and their aqueous solution saturations are Angelica ≦0.01%, Radix Radix ≦0.003%, Atractylodes Rhizome≦0.004%, Bletilla striata ≦0.006%, Poria ≦0.05%, Aconite ≦0.0002%, Zi Grass≦0.01%; therefore, its total saturation concentration is about not more than 0.1%.

The mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients can be extracted and prepared by one or more of the general high-temperature aqueous solution extraction method, organic solvent extraction method, ultrasonic extraction method, or supercritical fluid extraction method.

The active ingredients of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients can meet the definition of cosmetics and pharmaceuticals at the same time according to the instructions of Cosmetics Laws & Regulations of the US Food and Drug Administration. Means the invention according to scientific journals and the intended purpose of use is any ingredient having any function that can affect humans or other animals; and use for human body cleaning, beauty treatment, etc.

Preferably, the active ingredient of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients is a substance intended to be rubbed, poured, sprayed or sprinkled, introduced or wiped on the human body to cleanse, beautify, enhance firmness or change appearance.

More preferably, the active ingredient of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients means that its effect on the skin can be one of the following or a combination of effects, such as: whitening, promoting collagen synthesis, anti-inflammation, preventing dry and cracked skin, relieving itching, anti-allergic, anti-aging, anti-oxidation, immune regulation, anti-fibrosis, etc.

The mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients has different dosage forms such as O/W microemulsion (American Journal of Pharmtech Research, 2012), emulsion, or micelles (Cancers, July 2018) according to its different formulation combinations.

In the field of pharmacology, it is often necessary to maximize active ingredients in dosage form design, especially liquid dosage forms containing fat solubility and high physiological activity, such as paclitaxel, paclitaxel and other drugs such as paclitaxel. For such active ingredients that need to achieve an effective therapeutic dose and minimize the total volume of administration, the dosage form design should be as close to the solubility saturation of the active ingredient as possible; relatively, due to the characteristics of the active ingredient being nearly saturated, saturated, and supersaturated, it is easy to precipitate after mixing with water. The present invention utilizes the near-saturated, saturated, and super-saturated properties of the active ingredient to transform this shortcoming into an advantage of an external preparation. After mixing with water, the effective ingredient can be precipitated and absorbed to avoid being dissolved and completely cleaned by the detergent, and further cooperate with the hydration of the detergent on the skin to increase the absorption and effect of the active ingredient.

Skin dirt and acidic barriers can be removed by cleansers to increase the absorption of active ingredients, but the penetration of the stratum corneum requires the design of a cosmeceutical delivery system to overcome the barriers between keratinocytes and keratinocytes (Skin Pharmacol Physiol 2006: 19: 106-21). The present invention utilizes a combination of mild surfactants. This surfactant combination mainly uses the principle of the emulsification method to clean the skin and generate hydration of the stratum corneum. In this state, the stratum corneum not only increases the penetration, but also increases the capacity between the stratum corneum. The present invention uses this hydration phenomenon to increase the adhesion and penetration of the active ingredients at this appropriate time tology, Vol. 101, No. 3, September 1993); at the same time, the phenomenon that the concentration of active ingredients is close to saturation, saturation, or supersaturation (Pharmaceutical Research, July 2001, Volume 18, Issue 7, pp 1006–1011) is used to facilitate the deposition and adhesion of active ingredients and absorption through concentration differences to produce skin protection and maintenance effects, and because of this novel design principle can also be used at the same time Eliminates the possibility of over-cleaning the skin.

Long-chain betaines (Handbook for Cleaning/Decontamination of Surfaces), sodium lauroyl sarcosinate (Cosmetic Ingredient Review, September 2016), sodium lauroyl methyl isethionate (Cosmetic Ingredient Review, September 2013) and potassium cocoyl glyc Inate (Cosmetic Ingredient Review, September 2013) is a mild and low-irritating surfactant to the skin or eyes in various studies and scientific literature. This gentle cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients was invented using this mild and cleansing surfactant combination. One is to gently cleanse the skin, and the other is to dissolve the active ingredients to a concentration close to saturation, saturation, or supersaturation, and at the same time achieve the effect of cleaning and maintaining the skin.

In order to achieve the above-mentioned purpose of simultaneously cleaning, avoiding over-cleaning and maintaining the skin, the present invention provides a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients, which includes at least one surfactant and at least one near-saturated, or saturated, or supersaturated active ingredient that can improve skin texture and its preparation method. The surfactant is composed of one or more of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate in any combination and accounts for 5.00wt% to 70.00wt% of the composition of the invention; or multiple extracts in any combination and account for 0.1wt% to 10.00wt% of the composition of the invention; the composition of the invention may further include an appropriate amount of water, which accounts for 15.00wt% to 85.00wt% of the composition of the invention; the composition of the invention may further include an appropriate amount of cosmetic excipients, such as diluents, thickeners, stabilizers, fragrances, preservatives, cosurfactants, etc., the excipients account for 0wt% to 15.00wt% of the composition of the invention wt%.

Preferably, the surfactant long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate of the inventive composition accounts for 0wt% to 25.00wt%, 0wt% to 20.00wt%, 0wt% to 25.00wt%, 0wt% to 20.00wt% of the inventive composition wt%, and their sum must not be zero.

More preferably, the surfactant of the inventive composition is any combination of one or more of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate and accounts for 10.00wt% to 65.00wt% of the inventive composition.

Optimally, the surfactant of the composition of the invention is any combination of one or more of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate and accounts for 20.00wt% to 60.00wt% of the composition of the invention.

Preferably, the active ingredients of the composition of the invention are Angelica dahurica, Radix Baishui, Atractylodes macrocephala, Bletilla striata, Poria cocos, aconite, or comfrey, respectively 0wt% to 8.00wt%, 0wt% to 8.00wt%, 0wt% to 8.00wt%, 0wt% to 4.00wt%, 0wt% to 4.00wt%, 0wt% to 4.00wt%, 0wt% to 4.00wt%, And their sum must not be zero.

Preferably, the active ingredient of the composition of the invention is any combination of one or more of Angelica dahurica, Poria, Atractylodes macrocephala, Bletilla striata, Poria cocos, aconite, or comfrey, and accounts for 0.10wt% to 8.00wt% of the composition of the invention.

More preferably, the active ingredient of the composition of the invention is any combination of one or more of Angelica dahurica, Radix Baishui, Atractylodes macrocephala, Bletilla striata, Poria cocos, aconite, or comfrey, and accounts for 0.20wt% to 6.00wt% of the composition of the invention.

Optimally, the active ingredient of the composition of the invention is any combination of one or more of Angelica dahurica, Poria, Atractylodes macrocephala, Bletilla striata, Poria cocos, aconite, or comfrey, and accounts for 0.40wt% to 4.00wt% of the composition of the invention.

Preferably, the composition of the invention may further comprise an appropriate amount of water, accounting for 20.00wt% to 80.00wt% of the composition of the invention. More preferably, it accounts for 25.00wt% to 75.00wt% of the inventive composition. Optimally, it comprises from 30.00% to 70.00% by weight of the composition of the invention.

Preferably, the composition of the invention may further comprise an appropriate amount of cosmetic excipients, such as diluents, thickeners, stabilizers, fragrances, preservatives, or cosurfactants, etc., and the excipients account for 0.50wt% to 10.00wt% of the composition of the invention. Preferably, the excipient accounts for 1.00% to 8.00% by weight of the inventive composition. More preferably, the excipient accounts for 2.00% to 6.00% by weight of the inventive composition. Optimally, the excipient accounts for 4.00% to 6.00% by weight of the inventive composition.

The present invention provides a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients, which includes at least one surfactant and at least one active ingredient that is close to saturated, saturated, or supersaturated and can improve skin texture. The mild cleansing composition is prepared by the following preparation method. The preparation method includes the following steps: (i) adding the at least one active ingredient into a mixing container and adding an appropriate amount of water; Mix evenly; (iii) If necessary, add appropriate excipients, such as diluents, thickeners, stabilizers, fragrances, or preservatives, etc., continue to mix evenly, and return to room temperature.

According to the present invention, preferably, the active ingredients of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients and the preparation method thereof can be extracted through any combination of one or more of general high-temperature aqueous solution extraction, organic solvent extraction, ultrasonic extraction, or supercritical fluid extraction.

In order to make the above-mentioned features and advantages of the present invention more comprehensible, the following specific embodiments are described in detail in conjunction with the accompanying drawings.

In order to clean the skin at the same time, prevent over-cleaning, and achieve initial maintenance effect to enhance skin function, the present invention provides a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients. The composition includes one or more active ingredients; and one or more surfactants; the composition of the invention may further include an appropriate amount of water; the composition of the invention may further include an appropriate amount of cosmetic excipients.

Please refer to FIG. 1 , illustrating that the present invention utilizes surfactant and water to hydrate the stratum corneum, and the active ingredient is implemented in a form close to saturation, saturation, or supersaturation in the combination of the present invention so that the active ingredient is easy to precipitate on the surface of the stratum corneum and facilitates the absorption of the active ingredient.

The following examples serve to illustrate the invention. These examples are not intended to limit the scope of the invention in any way, but rather serve as an indication of how to practice the materials and methods of the invention.

In the embodiments of the present invention, at least one surfactant is selected from long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate, one or more of which are combined in any combination.

In the embodiments of the present invention, at least one active ingredient is selected from the extracts of Angelica dahurica, Radix Baishui, Atractylodes macrocephala, Bletilla striata, Poria cocos, aconite, or comfrey, and any combination of one or more of the above.

Example 1: Formulation 1 of mild cleansing composition containing active ingredients and its manufacturing method

In this example, every 1000 grams of the final product contains an active ingredient equivalent to 5 grams, and its production method is as follows: extract each active ingredient with a mixed extract with an equal weight ratio of alcohol and water, wherein the weight ratio of the mixed extract to the raw materials of each active ingredient is 10:1 to 50:1, the extraction temperature is 50 to 100 ° C, and the extraction time is 1 hour to 10 hours. 500 mg of extracts of Aconite, Aconite, and Comfrey, and mix with 50 grams each of cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, potassium cocoyl glycinate and appropriate amount of water. If necessary, add PEG-7 glyceryl cocoate, PEG-200 hydrogenated glyceryl Mix 10 grams of each palmate evenly, then add 10 grams of sodium chloride, stir and mix until uniform, and cool to room temperature. Table 1 is the composition list of the formula composition of Example 1.

Table 1, embodiment 1 formula composition composition table

Examples 2 to 12: Formulas 2 to 12 of mild cleansing compositions containing active ingredients. The manufacturing method is similar to that of Example 1, but the different formula compositions and extraction methods are also shown in Table 2. Table 2 is the composition list of the formula compositions of Examples 1 to 12. Table 3 is the extraction method of the active ingredients of the formula compositions of Examples 1 to 12. Table 4 is the extraction conditions of each extraction method.

Table 2, embodiment 1 to 12 formula composition composition table

Table 3, the extraction method of its active ingredient of the formula composition of embodiment 1 to 12

Table 4, the extraction conditions of each extraction method

The present invention provides a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients, the test results of which are as follows:

<Experiments close to saturation, saturation, and supersaturation>

Microscopically, Example 12 of the composition of the present invention was observed with a microscope. In addition, water and the composition of the present invention were mixed uniformly at a weight ratio of 1:1, and observed with a microscope at time points of 10, 60, 360, and 720 minutes. The saturated precipitation conditions were examined as shown in Figures 2 to 6. The results show that no precipitation occurs in the composition of the present invention (Figure 2); water and the composition of the present invention are mixed uniformly at a weight ratio of 1:1, and a small amount of precipitate visible under an optical microscope is produced at 10 minutes (Figure 3), a small amount of precipitate is produced in 60 minutes (Figure 4), agglomerated precipitate is produced in 360 minutes (Figure 5), and a large amount of precipitate is produced in 720 minutes (Figure 6); Agglutination will slowly occur after static storage. This test shows the excellent design of the composition of the present invention near the saturation critical value (Journal of Pharmaceutical Sciences, January 2012); it proves that the composition of the present invention has the effect of protecting and maintaining the skin when actually cleaning the skin under the concept of "Quality by Design".

<Avoid excessive cleaning and protection experiment>

The commercially available cleaning products (Dermisa Brightening Bar) and the composition Example 10 of the present invention were respectively used for 20 consecutive cleaning procedures of washing, drying and then washing the inner thighs.

The experiment used gloss and microscope inspection as observation tools, and simulated the general washing method for cleaning. The results showed that after repeated washing with general detergents in a short period of time, the skin surface was damaged. According to the improvement of smoothness, it can be expected that long-term use of the composition of the present invention will make the skin more fine and smooth, and further lead to a significant increase in glossiness to the extent that the difference can be recognized by the human eye.

Table 5. Avoid excessive cleaning experiments

To sum up, based on the prior art and general knowledge and cognition, the use of cleansers to clean the skin is likely to damage the stratum corneum and cause the skin surface to be rough, and then based on the use of skin care products such as creams on the damaged skin; in contrast, the composition of the present invention utilizes a design that is close to saturation, saturation, or supersaturation, so that active ingredients can be separated out and absorbed during the process of cleaning the skin and protect the skin from damage.

〈Moisture retention test〉

In Example 11, one decontamination and one cleansing maintenance are taken as the standard procedure for each face wash. After each cleansing, a commercially available skin detector (RUNVE Skin Analyzer) is used to measure. This detector includes three measurement values: moisture content, oil content, and fine and roughness. Among them, the oil content and fine roughness can be tested together with skin gloss; the humidity content is expressed by the average value of the forehead, left and right cheekbones. After about 3 weeks of cleaning and testing with general facial cleansing products (Dermisa Brightening Bar), and then using the composition of the present invention to clean the skin according to the above-mentioned standard use procedures for more than 4 weeks, the moisture content test chart (Figure 13) shows that whether it is just after cleansing or 10 minutes after cleansing, the moisture content index has improved significantly after two weeks.

Generally, the moisturizing degree of cleansing products after cleaning is between 40 and 42, and the moisturizing degree after drying is between 34 and 38. As shown in Table 6, referring to the classification of moisturizing degree in the instruction manual, it can be seen that it falls in the normal skin area after cleaning, and loses moisture to dry skin in 10 minutes. In contrast, after using the composition of the present invention for about two weeks, the moisturizing degree after cleaning is about 43 to 48, and the moisturizing degree after drying is about 38 to 44. Contains a suitable humidity skin zone, and the moisture will be lost to the normal skin zone in 10 minutes.

Table 6. Description of moisture retention

〈Glossiness Test〉

Generally, dermatologists understand skin gloss as the adhesion of oil secreted by sebaceous glands and other substances in the environment to increase skin gloss (Biomedical Optics Express). This environment on the skin can easily lead to the occurrence of skin diseases such as acne and seborrheic dermatitis. On the contrary, when the skin is cleaned without the interference of the above-mentioned sebum, the skin still shows obvious gloss because of long-term healthy skin composition, such as reducing skin roughness (Skin Research and Technology), reducing wrinkles, and Optimum hydration is the expression of fine, healthy skin, which may be promoted eg by epidermal growth factor or collagen hyperplasia (WO2005037270A1). The composition of the present invention is rich in active ingredients enough to make the skin healthier, thereby reducing wrinkles and increasing the gloss of the skin after cleansing (International Journal of Research in Pharmacy and Chemistry).

Take one decontamination and one cleansing maintenance every time you wash your face as a standard procedure. After cleaning every day, use a gloss meter (BYK Micro-Gloss) to detect the skin gloss on the forehead, the flattest area of the face. After about 3 weeks of cleaning and testing with general face cleansing products (Dermisa Brightening Bar), and then using the composition of the present invention to clean the skin according to the above-mentioned standard use procedures for more than 4 weeks, from the glossiness test chart (Figure 14), it can be seen that the glossiness index showed a significant improvement after two weeks, whether it was just after cleansing or 10 minutes after cleansing.

Generally, the glossiness of the face of people with sebum is about 2GU (Gloss unit), and it will decrease to about 1GU after cleaning or the roughness of the skin, and it will increase to about 2.5GU with the increase of skin fineness or the use of maintenance cosmetics (Optical Review). However, the composition of the present invention can achieve a glossiness of about 3GU to 5GU after long-term use and before using various skin care products. The difference in glossiness can be discerned by the human eye (the difference can be discerned by the human eye is about 3GU). Therefore, ordinary users can clearly feel the fineness of the skin and see the increase in glossiness. Since the hydrated skin is not yet dry after cleansing and the stratum corneum has not returned to its original state, the glossiness falls to about 3GU. After 10 minutes of recovery, the glossiness can normally appear to about 5GU.

Comparative Example 13: Mild Cleansing Composition Formulation 13 Containing Unsaturated Active Ingredient and Its Manufacturing Method

In this comparative example, each 1000 grams contains an active ingredient equivalent to 0.83 grams. The production method is as follows: extract the extracts in equal proportions with alcohol and water, and contain 100 mg each of Angelica dahurica, Radix Baishui, and Atractylodes macrocephala, and 50 mg each of Bletilla striata, Poria cocos, aconite, and comfrey, and cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium lauroyl methyl Mix 50 grams each of isethionate and potassium cocoyl glycinate with an appropriate amount of water. If necessary, heat to a homogeneous state, add 10 grams each of PEG-7 glyceryl cocoate and PEG-200 hydrogenated glyceryl palmate and mix evenly, then add 10 grams of sodium chloride, stir and mix until uniform, and cool to room temperature. Table 7 shows the composition of the formula composition of Comparative Example 13.

Table 7, Comparative Example 13 formula composition composition table

This comparative example provides a mild cleansing composition containing an unsaturated active ingredient, and its various comparative test results are as follows:

<Experiments close to saturation, saturation, and supersaturation>

Microscopically, Comparative Example 13 and water were mixed uniformly in equal proportions by weight, and observed with a microscope at time points 10 and 60 minutes to check whether there was precipitation in the unsaturated state, as shown in Figures 15 and 16. The results showed that no precipitation occurred in the unsaturated comparative example 13.

<Avoid excessive cleaning and protection comparison experiment>

In Comparative Example 13, the inner thighs were washed, dried, and then washed for 20 consecutive cleaning procedures. The results are shown in Table 8 and the comparison experiment of avoiding excessive cleaning in FIGS. 17 to 20 .

Table 8. Avoid excessive cleaning experiments

The experiment used glossiness and microscope inspection as observation tools, simulating general washing methods for cleaning, and the results showed that the skin surface of Comparative Example 13 did not change significantly after repeated washing in a short period of time; although the skin smoothness did not change significantly from the results of glossiness (1.4GU before washing and 1.4GU after washing), and no significant difference was found in the cell type before and after washing, but observed under the microscope: the glossiness after washing was still lower than before washing.

Based on the comparison of saturated Example 10 and unsaturated Example 13 in avoiding excessive cleaning and protection, the experimental results show that in addition to the function of avoiding excessive skin cleaning and protection, saturated Example 10 can also increase the smoothness of the skin; on the contrary, the function of unsaturated Example 13 for avoiding excessive skin cleaning and protection is not significant. This experiment shows that the invention of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients has its special novelty and advancement.

Although the present invention has been disclosed as above with the embodiments, it is not intended to limit the present invention. Anyone with ordinary knowledge in the technical field may make some changes and modifications without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention should be defined by the scope of the appended patent application as the criterion.

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Fig. 1 is a schematic diagram illustrating that the present invention uses surfactants and water to hydrate the stratum corneum, and the active ingredients are implemented in a nearly saturated or saturated or supersaturated form to facilitate skin absorption. Fig. 2 is a series of micrographs enlarged by different magnifications, showing the precipitation state of the composition Example 12 of the present invention before mixing with water. Fig. 3 is a series of microscopic pictures enlarged at different magnifications, showing the precipitation state at the time point 10 minutes after the composition Example 12 of the present invention is mixed with water at a weight ratio of 1:1. Fig. 4 is a series of microscopic photos enlarged at different magnifications, showing the precipitation state at the time point of 60 minutes after the composition Example 12 of the present invention is mixed with water at a weight ratio of 1:1. Fig. 5 is a series of microscopic photos enlarged at different magnifications, showing the precipitation state at the time point of 360 minutes after the composition Example 12 of the present invention was mixed with water at a weight ratio of 1:1. Fig. 6 is a series of microscopic pictures enlarged by different magnifications, showing the precipitation state at the time point 720 minutes after the composition Example 12 of the present invention is mixed with water at a weight ratio of 1:1. FIG. 7 is a 200-fold magnified microscopic photo showing the state of the skin before being washed with a general cleanser. Fig. 8 is a 200-fold magnified micrograph showing the state of the skin before being washed with the composition of Example 10 of the present invention. Fig. 9 is a microscopic picture enlarged by 30 times, showing the state of the skin being continuously washed 20 times with a general cleanser. Fig. 10 is a 30-fold magnified microscopic photo showing the state of the skin being continuously washed 20 times with the composition of Example 10 of the present invention. Fig. 11 is a microscopic picture enlarged by 200 times, showing the state of the skin being continuously washed 20 times with a general cleanser. Fig. 12 is a magnified micrograph of 200 times, showing the state of the skin being continuously washed 20 times with the composition of Example 10 of the present invention. Fig. 13 is a test chart of moisture retention, illustrating the moisture retention of the skin immediately after cleansing and 10 minutes after cleansing with the composition of Example 11 of the present invention. Fig. 14 is a test graph of glossiness, illustrating the glossiness of the skin immediately after cleansing and 10 minutes after cleansing with the composition of Example 11 of the present invention. Fig. 15 is a series of microscopic photos enlarged at different magnifications, showing the precipitation state at the time point 10 minutes after the composition of Comparative Example 13 of the present invention was uniformly mixed with water at a weight ratio of 1:1. Fig. 16 is a series of microscopic photos enlarged at different magnifications, showing the precipitation state at the time point of 60 minutes after the composition of Comparative Example 13 of the present invention was uniformly mixed with water at a weight ratio of 1:1. Fig. 17 is a 30-fold magnified micrograph showing the state of the skin before being washed with the composition of Comparative Example 13 of the present invention. Fig. 18 is a 30-fold magnified microscopic photo, showing the state of the skin being continuously washed 20 times with the composition of Comparative Example 13 of the present invention. Fig. 19 is a 200-fold magnified micrograph showing the state of the skin before being washed with the composition of Comparative Example 13 of the present invention. Fig. 20 is a microscopic picture enlarged by 200 times, showing the state of the skin in the comparative example 13 of the composition of the present invention washed continuously for 20 times.

Claims (10)

A mild cleansing composition comprising: at least one surfactant selected from at least two of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate or potassium cocoyl glycinate, and the surfactant Accounting for 5wt% to 70wt% of the mild cleansing composition; and at least one supersaturated active ingredient that can improve skin texture, including 0.10 to 1.80wt% of Angelica dahurica extract, 0.10 to 1.80wt% of Baishao extract, 0.10 to 1.80wt% of Baizhu extract, 0.05 to 0.80wt% of Baiji extract, 0.05 to 0.80wt% of Lingporia extract, 0.0 5 to 0.80wt% of aconite extract and 0.05 to 0.20wt% of comfrey extract, wherein the active ingredient accounts for 0.1wt% to 10wt% of the mild cleansing composition. The mild cleansing composition as described in claim item 1, wherein the surfactant contains at least two of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate and potassium cocoyl glycinate, and the surfactant is active The agent comprises 10wt% to 65wt% of the mild cleansing composition. The mild cleansing composition as described in claim item 2, wherein the surfactant comprises 5.0 to 20.0wt% long-chain betaines, 5.0 to 20.0wt% sodium lauroyl sarcosinate, 5.0 to 20.0wt% sodium lauroyl methyl isethionate and At least two of 5.0 to 20.0 wt% potassium cocoyl glycinate. The mild cleansing composition as described in item 1 of the claim, wherein the active ingredients include 0.60 to 1.80wt% Angelica dahurica extract, 0.60 to 1.80wt% Baishui root extract, 0.60 to 1.80wt% Atractylodes macrocephala extract, 0.40 to 0.80wt% Bletilla striata extract, 0.20 to 0.80wt% Poria cocos extract, 0.20 to 0.80wt% aconite extract, and 0.1 0 to 0.20wt% of at least two of comfrey extracts, and the active ingredient accounts for 0.2wt% to 6wt% of the mild cleansing composition. The mild cleansing composition as described in item 1 of the claim further includes: a viscosity regulator, which includes sodium chloride, accounting for 0.1 to 2.0 wt% of the mild cleansing composition; and at least one thickener comprising PEG-40 hydrogenated castor oil, PEG-7 glyceryl cocoate, PEG-200 hydrogenated glyceryl palmitoleate or a combination of any two thereof, wherein the at least one thickener accounts for 0.50 to 4.00 wt% of the mild cleansing composition. The mild cleansing composition as described in item 5 of the claim, wherein the at least one thickener comprises 0.50 to 4.0 wt% of PEG-40 hydrogenated castor oil, 0.05 to 1.00 wt% of PEG-7 glyceryl cocoate, 0.05 to 1.00 wt% of PEG-200 hydrogenated glycerin palm oleate or a combination of any two thereof. The mild cleansing composition as described in item 1 of the claim further includes an appropriate amount of water, wherein the appropriate amount of water accounts for 20wt% to 80wt% of the mild cleansing composition. The mild cleansing composition as described in item 7 of the claim further includes an appropriate amount of cosmetic excipients, wherein the appropriate amount of cosmetic excipients accounts for 0.50wt% to 10.00wt% of the mild cleansing composition. The mild cleansing composition as described in item 1 of the claim, wherein the preparation method of the extract of the active ingredient is general high-temperature aqueous solution extraction, organic solvent extraction, ultrasonic extraction, or supercritical fluid extraction. A mild cleansing composition as described in any one of Claims 1 to 9 is used to prepare a composition for improving skin texture, skin protection and skin maintenance, including administering an effective dose of the mild cleansing composition to the skin surface of the desired individual; wherein, the surfactant cleans the skin and produces hydration of the cuticle of the skin to increase the penetration of the cuticle of the skin and the capacity between the cuticle of the skin. Protective and skin care benefits.