TWI721961B - Supplemental liquid comprising dietary fiber - Google Patents

Abstract

The problem to be solved by the present invention is to provide a novel supplemental liquid, which is capable of easily and rapidly supplementing the amount of essential components such as salt in enteral nutrition and is of versatility for most subjects with various conditions. The present invention relates to a supplemental liquid for enteral nutrition, consisting of minerals, water, and dietary fiber; and a supplemental liquid in a container, formed by heat sterilization of the container containing the supplemental liquid.

Description

Supplement liquid containing dietary fiber

The present invention relates to a supplement for enteral nutrition.

Nutritional therapy is used to supplement nutrients for patients with low digestive tract functions, infants, elderly people, and those in need of care, when food intake is insufficient or cannot be taken. In this nutritional therapy, there are enteral nutrition and intravenous nutrition. Enteral nutrition, compared to intravenous nutrition, is widely used as a safe and low-cost nutritional therapy. In addition, because intravenous nutrition is a nutritional therapy that does not go through the digestive tract, there are problems such as metabolic complications such as abnormal glucose metabolism, digestive complications such as atrophy of the digestive tract mucosa, and infections caused by catheters. Therefore, in recent years, the following principle has been gradually established: As long as the digestive organs are still functioning, do not choose intravenous nutrition but choose enteral nutrition.

In commercial products of liquid foods for enteral nutrition, in general, the formulation is designed from the viewpoint of the necessary energy (calories) and the concentration of various nutrients. At medical sites and care sites, it is necessary to adjust the energy, water content, and salt-converted amount (sodium content) of a meal based on the status of the person who actually consumes liquid food. For example, there are also continuous attempts to produce liquid foods prepared by adding dietary fiber to enteral nutrition composition (Patent Documents 1 to 3), but as common commercial products, the current situation is still a fixed composition, especially limited The energy, moisture content, and salt are prepared so that it can be used by the largest number of subjects. However, the necessary energy, water content, and salt conversion amount in the prescriptions prescribed by doctors and other doctors vary greatly depending on the status of the subjects actually ingesting liquid foods, and it is necessary to calculate these based on individual conditions. After the necessary amount of ingredients, make up for the lack of it in the liquid food.

For example, in a medical field or a care field, generally speaking, in order to supplement the lack of water in liquid food, a method of opening a container of liquid food and directly adding cold water to it is used for mixing. In addition, in order to make up for the lack of salt, the following method is adopted: after dissolving salt in cold boiled water, preparing the salt solution, and then administering the salt solution after the liquid food is administered; or, in cold boiling water. The method of dissolving salt in the salt solution to prepare the salt solution, and then injecting the salt solution into the pipe of the food and drink using a syringe.

So far, the applicant of this patent case has provided the following nutritional components in the nutritional composition of liquid foods that can be used for enteral nutrition in accordance with the needs of the medical field or the care field, for example: the energy can be easily adjusted , Water content, and salt-converted amount (sodium content) nutritional composition (Patent Documents 4 and 5); in order to prevent/treat bed sores in bedridden patients, a nutritional composition of copper or zinc can be effectively provided (Patent Document 6). Furthermore, with regard to the diluent used with the nutritional composition, for example, the following diluent for the liquid food composition, etc. have been provided, This diluent does not dilute mineral components or vitamin components, but is capable of diluting the concentration of components that become an energy source (Patent Document 7).

[Prior Technical Literature] (Patent Document)

Patent Document 1: Japanese Patent Application Publication No. 2009-213367

Patent Document 2: Japanese Patent Laid-Open No. 06-298650

Patent Document 3: Japanese Patent Application Publication No. 2011-4702

Patent Document 4: Japanese Patent No. 5160569

Patent Document 5: Japanese Patent No. 5404558

Patent Document 6: Japanese Patent No. 3871262

Patent Document 7: Japanese Patent No. 5449783

In the diligent research of the present inventors in this technical field, when the subjects who actually ingest liquid foods are often accompanied by side effects such as diarrhea or constipation, in order to improve this point, the following idea is proposed: The supplementary liquid contributed will be extremely useful in terms of simplicity and safety.

Therefore, the object of the present invention is to provide a novel supplement for enteral nutrition, which serves as a supplement for liquid foods in enteral nutrition, which can reduce diarrhea or diarrhea while simply and quickly supplementing water content, salt, etc. Side effects such as constipation.

In order to solve the above-mentioned problems, the inventors discovered the following facts, and as a result of further studies, completed the present invention. The present invention can provide a replenishing liquid, which can not only replenish the insufficient amount of sodium, etc., by using the replenishing liquid for the previous liquid food, that is, the replenishing liquid composed of mineral components such as salt and further adding dietary fiber to the water. Mineral quality and water content, and no need to administer laxatives, etc., can also be extremely simple and safe to reduce side effects such as diarrhea or constipation.

That is, the present invention relates to the following technologies:

[1] A supplement for enteral nutrition, which is composed of mineral components, water and dietary fiber.

[2] The replenishment liquid according to [1], wherein the mineral component contains sodium.

[3] The supplement liquid according to [1] or [2], which further contains vitamin components.

[4] The replenishment liquid according to any one of [1] to [3], wherein the sodium content is 0.3 to 26 g/100 mL in terms of salt conversion.

[5] The replenisher as described in any one of [1] to [4], wherein the total weight of sodium ions and the weight of chloride ions relative to the weight of the total mineral components is 80 to 100% by weight .

[6] The replenisher according to any one of [1] to [5], wherein the weight of sodium ions is 60 to 200% by weight relative to the weight of chloride ions.

[7] A replenisher to be placed in a container, which is obtained by heat-sterilizing a container containing the replenisher as described in any one of [1] to [6].

[8] The replenishment liquid put into the container as described in [7], wherein the container is a closed type.

[9] The replenisher placed in a container according to [7] or [8], wherein the container has one or more narrow mouths for outflow and/or mixing.

[10] A method of manufacturing a replenishment solution, which manufactures the replenishment solution described in any one of [1] to [9]; the manufacturing method includes the following step: a mixing step, which makes mineral components and dietary fiber Mixing in water; a filling step, which fills the water mixed with mineral components and dietary fiber obtained in the mixing step into a container; and, a heat sterilization step, which will be obtained in the filling step and mixed with mineral components and The food fiber water is pasteurized.

Furthermore, the present invention relates to the following technologies:

[11] The use of a supplement liquid for enteral nutrition. The supplement liquid is composed of only mineral components, water and dietary fiber.

[12] The use according to [11] above, wherein the mineral component of the replenishing liquid contains sodium.

[13] The use according to [11] or [12] above, wherein the supplement liquid further contains a vitamin component.

[14] The use according to any one of [11] to [13] above, wherein the sodium content of the supplement liquid is 0.3 to 26 g/100 mL in terms of salt.

[15] The use according to any one of the aforementioned [11] to [14], wherein the total weight of sodium ions and the weight of chloride ions in the replenishing liquid relative to the weight of the total mineral components is 80 ~100% by weight.

[16] The use according to any one of [11] to [15] above, wherein the weight of sodium ions is 60 to 200% by weight relative to the weight of chloride ions.

[17] The use according to any one of [11] to [16] above, wherein the replenisher is contained in a container, and the container containing the replenisher is heat-sterilized.

[18] The use as described in [17] above, wherein the container is a closed type.

[19] The use according to [17] or [18] above, wherein the container is provided with one or two or more narrow mouths for outflow and/or mixing.

According to the present invention, in enteral nutrition, not only can the necessary mineral components be supplemented in accordance with the prescription of each target person, but also the symptoms of constipation and the like of the target person can be improved without using laxatives. Also, from the point of view that the mineral components and dietary fiber are pre-mixed in the form of supplementary liquid, there is no need to dissolve table salt in cold boiling water to prepare an aqueous solution of table salt, and then add it to the intestinal nutrition. Complicated and unsanitary operations such as the composition, there is no need to separately supplement the mineral components and dietary fiber. Therefore, from the viewpoint that the number of times of replenishment to the target person can be set to only once, the implementation of enteral nutrition can not only save manpower in the work, but also greatly reduce the possibility of contamination due to microorganisms and the like. Hygienely replenish mineral ingredients or dietary fiber.

In addition, the replenishment liquid of the present invention is basically composed of three kinds of mineral components, water, and dietary fiber, and can be used only for the constituent components of the replenishment liquid according to the individual conditions of the subjects actually ingested. Therefore, it only consumes sodium and dietary fiber that are easily lacked by most people who actually consume liquid foods, such as elderly people, without excessive intake of unnecessary other ingredients. Therefore, the supplement of the present invention is versatile for the subjects. , And can be taken easily, quickly and safely.

For another example, when a commercially available beverage containing dietary fiber is used as a supplement, the beverage usually contains nutrients that are not required by the subject due to taste, etc., or adjusts the salt concentration to a low level. To obtain the desired sodium content, there is a problem of excess water content, but according to the present invention, it is possible to prepare a replenishing liquid capable of appropriately replenishing a sufficient amount of sodium.

The replenishing liquid in the present invention is a liquid used to replenish a component that is insufficient in a necessary amount to a person who is administered a liquid food or the like. In principle, it means a liquid in a state where only the components to be administered (that is, components that are insufficient for the person to be administered) are prepared in a solvent such as moisture. The supplement in the present invention can be clearly distinguished from the following inventions, etc., for example: the purpose is to take in nutrition comprehensively, The liquid food is designed with a variety of ingredients; or it can be used to dilute the specific ingredients in the liquid food to a fixed concentration of diluent, etc.

The so-called enteral nutrition in the present invention includes oral feeding in which the subject ingests the supplement from the mouth, and tube feeding in which the supplement is administered to the subject using a tube. Typically, more The best way is to feed the diet. Furthermore, the tube-fed diet includes oral, nasal, and tube-fed.

The properties of the supplement liquid for enteral nutrition in the present invention are liquid, fluid (thick), gel or paste, etc., typically, preferably liquid or fluid. In addition, it may be a use form such as the following: the replenishment solution for enteral nutrition is concentrated and/or dried, and then prepared into a powder form (solid), etc., when enteral nutrition is implemented, water etc. are added to prepare it. Liquid or fluid, etc. In addition, the classification of supplements used for enteral nutrition is an element diet, a formula liquid food or a formula nutrient, a semi-formulated liquid food or a semi-formulation nutrient, or a natural thick liquid food, etc. , Preferably a formula liquid food or a formula nutrient, or a semi-formula liquid food or a semi-formula nutrient, and more preferably a formula nutrient or a semi-formula nutrient.

The supplement liquid of the present invention is a supplement liquid used for enteral nutrition. As one aspect, it may be composed of only three components: mineral components, water, and dietary fiber.

Here, the mineral components include sodium, calcium, iron, phosphorus, magnesium, potassium, copper, zinc, chromium, selenium, manganese, molybdenum, iodine, etc.; preferably sodium, calcium, magnesium, potassium; Preferred are sodium and calcium; more preferred is sodium.

Among the mineral components that become the source of sodium, table salt (sodium chloride), sodium acetate, sodium citrate, sodium hydroxide, sodium carbonate, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate, metaphosphoric acid Sodium, sodium pyrophosphate, sodium tripolyphosphate, etc.; preferably table salt, sodium acetate, sodium citrate; more preferably table salt. Furthermore, one or two or more sources of the sodium can be used.

When the replenishment solution of the present invention contains sodium, its content, for example, can be 0.3~26g/100mL in terms of salt conversion amount, preferably 0.3~10g/100mL, more preferably 0.3~2g/100mL. In addition, in the present invention, the amount of salt converted is a value obtained by converting the amount of sodium contained in the nutritional composition into the amount of sodium chloride (salt).

In addition, when the replenishing liquid of the present invention contains sodium ions and chloride ions, the total weight of sodium ions and the weight of chloride ions relative to the weight of the total mineral components in the replenishing liquid may be, for example, 80 to 100 weight. %, preferably 85 to 100% by weight, more preferably 90 to 100% by weight. In addition, the weight of sodium ions relative to the weight of chloride ions can be, for example, 60 to 200% by weight, preferably 60 to 150% by weight, and more preferably 60 to 100% by weight.

The water used in the replenishing liquid of the present invention includes tap water, well water, activated carbon water, pure water, ultrapure water, purified water, ion exchange water, etc., and those whose total mineral content is known are suitable. . again In addition, from the viewpoint of enabling treatment with the concentration of total mineral components set to 0, pure water, ultrapure water, purified water, ion-exchanged water is preferable, and ion-exchange water is more preferable.

The dietary fiber used in the supplement of the present invention may include: galactomannan decomposition products, indigestible dextrin, reduced indigestible dextrin, cellulose, etc., and can be used water-soluble and water-insoluble Any kind of dietary fiber. Furthermore, from the viewpoints of being easy to stably and uniformly disperse in the replenishing solution of the present invention, water-soluble dietary fibers such as galactomannan decomposition products, indigestible dextrins, and reduced indigestible dextrins are preferred. , More preferably galactomannan decomposition product. In addition, the galactomannan decomposition product includes: locust bean gum decomposition product, Tara gum decomposition product, Guar gum decomposition product, guar gum hydrolysate, etc., preferably It is a guar gum decomposition product, a guar gum hydrolysate, and more preferably a guar gum hydrolysate. The content of dietary fiber in the supplement liquid used in the present invention may be, for example, 0.5-15% by weight, preferably 1-12% by weight, and more preferably 2-10% by weight.

The replenishment liquid of the present invention is composed of mineral components, water and dietary fiber. By using the replenishment liquid of the present invention, the subject can easily and quickly take in water and mineral components according to the state of the subject actually ingested. , The necessary amount of dietary fiber. Therefore, the present invention is a supplement liquid containing only water, mineral components, and dietary fiber, for example, it does not contain components such as protein or lipid. Also, from the point of view that the present invention is a supplement liquid containing only water, mineral components, and dietary fiber, its energy is very low, and it is different from normal liquid foods and other nutrient compositions. For example, For example, it may be less than 1 kcal/mL, preferably less than 0.5 kcal/mL, and more preferably less than 0.2 kcal/mL.

In addition, in the replenishment liquid of the present invention, in addition to the constituent components, that is, mineral components, water, and dietary fiber, vitamin components can be further used as constituent components. With this aspect, for the subject, in addition to mineral components, water, and dietary fiber, it is also possible for the subject to easily and quickly add vitamin components. Here, the vitamin components include vitamin B1, vitamin B2, niacin, pantothenic acid, vitamin B6, biotin, folic acid, vitamin B12, vitamin C, vitamin A, vitamin D, vitamin E, vitamin K, and the like.

The replenisher of the present invention can be manufactured by the following manufacturing method, the manufacturing method comprising: a mixing step, which mixes mineral components and dietary fiber in water; and a filling step, which mixes the obtained in the mixing step The water containing mineral components and dietary fiber is filled into the container; and, in the heat sterilization step, the water obtained in the filling step and mixed with the mineral components and dietary fiber is heat sterilized.

In the mixing step, a specific amount of mineral components and dietary fiber are mixed in water to prepare a liquid composition. At this time, vitamin components can also be mixed. In addition, heating or stirring is performed as needed, whereby each component can be sufficiently dissolved. As a result, the components in the liquid composition are mixed and dissolved, dispersed, or suspended. In the filling step, the liquid composition is filled in a retortable pouch or a soft pack. In the heat sterilization step, in order to make the subject take it hygienically (Injection) The liquid composition is subjected to heat sterilization to suppress or prevent contamination by microorganisms and the like to a necessary degree.

In the manufacturing method of the replenishment solution of the present invention, the liquid composition can also be heat sterilized (UHT sterilization, high temperature short time (HTST) sterilization, etc.) and then filled aseptically (aseptic packaging method, etc.) ) To a specific container; or the liquid composition can be filled in a specific container and then heat sterilized (retort sterilization (high pressure steam sterilization, etc.), etc.). In this case, from the viewpoint of easy sterilization and simple manufacture of the liquid composition, it is preferable to fill the retort pouch or flexible packaging bag with the liquid composition and then perform autoclave sterilization for sterilization.

Here, the heat sterilization method can be used: indirect heat sterilization method (plate type sterilizer (heat exchanger), tube type sterilizer (heat exchanger), etc.), direct heat sterilization method (steam jet sterilizer, steam injection Type sterilizer, etc.), energized heat sterilization method (Joule type sterilizer, etc.), retort sterilizer, etc. In this case, it is preferable to use a retort sterilizer from the viewpoint of easy sterilization and simple manufacture of the liquid composition.

The container accommodating the replenisher of the present invention is preferably a closed container (sealed package) from the viewpoint that it can effectively block the content, that is, the replenisher from the outside. As the form of the container, typically, a paper bag, a retort bag, a flexible packaging bag, a fixed-shaped container, a can-shaped container, etc., are preferably a paper bag, a retort bag, a flexible packaging bag, and more preferably a retort bag or a flexible packaging bag. As the material of the container, typically: paper, plastic, glass, metal, etc., preferably paper, plastic, and more preferably plastic.

In addition, the container containing the replenisher of the present invention is preferably: a closed paper container formed of a paper material formed by laminating aluminum foil and synthetic resin (polyethylene, etc.); or a closed type Plastic containers that use soft synthetic resin materials (plastic vinyl chloride resins, polyurethane resins, polyethylene resins, ethylene-vinyl acetate copolymers, ethylene-α-olefin copolymers and other polyolefins; polyfluorocarbons; polyamides) Amine, etc.). More preferably, it is a closed type plastic container. In this case, suitable is a soft container that can be heat-sterilized (sterilized) after accommodating the replenisher of the present invention.

In addition, the container containing the replenisher of the present invention preferably has one or more narrow-mouthed containers for outflow and/or mixing, and more preferably has the following mechanism as the narrow-mouthed container : The mechanism is sealed before enteral nutrition is implemented, and can be directly connected to the narrow mouth of a pipe or other container during enteral nutrition. At this time, by using the above-mentioned hermetic container, it is not necessary to open the container over a large area, or only to open the narrow part to open the container to a minimum, so that the nutritional composition and the like can be added to the replenishing liquid of the present invention. And it can effectively reduce the contact of the content, that is, the replenishment liquid, with the outside air, and can suppress or prevent the contamination of microorganisms and the like to a necessary degree.

One aspect of the present invention relates to the use of the above supplementary liquid for enteral nutrition.

In the aforementioned applications, for the sake of simplicity, in the replenishment liquid of the present invention, the content of the constituent components, that is, the content of mineral components, water, and dietary fiber can be set to an integral multiple of a fixed content. Combine two or more options Replenishment liquids with different contents of one or more of the mineral components, moisture, and dietary fiber can be freely formulated and designed, and the mineral components, moisture, and dietary fiber contents of the combined replenishment liquid can be adjusted at the same time. In this case, there is no need to calculate the necessary amounts of mineral components, water, and dietary fiber based on the prescription corresponding to the state of the subject who ingested the supplement of the present invention, and to additionally add the work, which can save manpower.

In the above aspects of the replenishing liquid of the present invention, the so-called combination means: combining the monomers of the replenishing liquid of the present invention as monomers; and, combining the monomers and mixing the replenishing liquid Part of it is combined with a monomer and/or a part of a replenisher mixed with a combination of monomers. By combining two or more kinds of replenishing liquids of the present invention, the replenishing liquids with adjusted mineral content, water content, and dietary fiber content can be administered by setting the monomers of each replenishing liquid to be combined in one portion, or After the monomers of two or more replenishing liquids are mixed with each other, all or a part of the mixed replenishing liquid is administered in one portion.

In the above aspect of the replenishment solution of the present invention, the number of other one or more replenishment solutions that are combined can be, for example, 1 from the viewpoint that the combined replenishment solution can be used in various prescriptions. ~5 types, from the point of view of easy calculation and work burden of preparation, preferably 1~4 types, more preferably 1~3 types.

In the above aspect of the replenishment liquid of the present invention, the content of the mineral components can be adapted to various prescriptions and the content of mineral components can be easily calculated from the combined content of the mineral components of the replenishment liquid. From the point of view, the amount of sodium is converted to the amount of salt converted into the amount of table salt In total, it is preferably an integer multiple of 1g, 5g, 10g, or 20g. From the viewpoint of reducing the number of items, it is more preferably an integer multiple of 1g, 5g, or 10g, and particularly preferably an integer multiple of 1g or 5g.

In the above-mentioned aspect of the replenishment liquid of the present invention, the water content is similarly compared from the viewpoint that the water content of the combined replenishment liquid can be adapted to various prescriptions and that the water content can be easily calculated. Preferably, it is an integer multiple of 10 mL, 25 mL, 50 mL, or 100 mL. From the viewpoint of reducing the number of items, it is more preferably an integer multiple of 25 mL, 50 mL or 100 mL, and particularly preferably an integer multiple of 50 mL or 100 mL.

In the above aspect of the replenishment solution of the present invention, the dietary fiber content of the replenishment solution can also be adapted to various prescriptions, and the dietary fiber content can be easily calculated from the viewpoint of the combination of the dietary fiber content of the replenishment solution. In terms of view, it is preferably an integer multiple of 1g, 5g, 10g or 20g, and from the viewpoint of reducing the number of items, it is more preferably an integer multiple of 1g, 5g, or 10g, and particularly preferably an integer multiple of 5g or 10g.

In the above aspect of the replenishment liquid of the present invention, as specific examples of the blending of mineral components, water, and dietary fiber, the mineral components, water, and dietary fiber contents of the combined replenishment liquid can also be adapted to various types. Various prescriptions are easy to calculate, and from the viewpoint of reducing the number of items, for example, the amount of salt converted from sodium to salt as a mineral component, water and dietary fiber, etc., are as follows: Replenisher: 1g, 200mL and 5g; 1g, 300mL and 5g; 1g, 200mL and 10g; 2g, 200mL and 10g; 2g, 300mL and 10g; 2g, 200mL and 5g, etc. Preferably, it can be listed as The amount of salt, water, and dietary fiber in which the amount of sodium is converted into the amount of salt in mineral components are supplemented liquids with the following contents: 1g, 200mL, and 5g; and 2g, 200mL, and 10g, etc.

Hereinafter, the present invention will be described in further detail based on embodiments, but the present invention is not limited to these embodiments, and various changes can be made without departing from the technical idea of the present invention.

(Example 1) Formulation example of liquid composition (replenisher) (1)

In 200 mL of warm water (60°C), mix (add) 2 g of table salt and 10 g of dietary fiber (galactomannan decomposition product, "Sunfiber R" (manufactured by Taiyo Chemical Co., Ltd.)) to prepare a liquid composition (1a) ). After containing (filling) 200 mL of the liquid composition (1a) in a flexible container made of polyethylene resin, it is subjected to high-pressure steam sterilization (sterilizer sterilization (120°C, 10 minutes)) to prepare a liquid composition ( 1b). Furthermore, the sodium (Na) concentration is 400 mg/100 mL, and the chlorine (Cl) concentration is 600 mg/100 mL.

At this time, even if the liquid composition (1b) is stored under specific conditions (40°C, 2 months), it will not cause spoilage or poor flavor. In addition, when the liquid composition (1b) is connected by a pipe to suck up the liquid composition (1b), the liquid composition (1b) will not be exposed to the atmosphere, and water, salt, etc. can be transported hygienically. Food fiber.

(Example 2) Formulation example (2) of liquid composition (replenisher)

In 200 mL of warm water (60°C), 1 g salt and 5 g dietary fiber (galactomannan decomposition product, "Sunfiber R" (manufactured by Taiyo Chemical Co., Ltd.)) are blended (added) to prepare a liquid composition (2a) ). After containing (filling) 200 mL of the liquid composition (2a) in a flexible container made of polyethylene resin, it is subjected to high-pressure steam sterilization (sterilizer sterilization (120°C, 10 minutes)) to prepare a liquid composition ( 2b). Furthermore, the concentration of sodium (Na) is 200 mg/100 mL, and the concentration of chlorine (Cl) is 300 mg/100 mL.

At this time, even if the liquid composition (2b) is stored under specific conditions (40°C, 2 months), it will not cause spoilage or poor flavor. In addition, when the liquid composition (2b) is connected with a pipe to suck up the liquid composition (2b), the liquid composition (2b) is not exposed to the atmosphere, and can hygienic transportation of water, salt, and water. Food fiber.

(Example 3) Formulation example (3) of liquid composition (replenisher)

In 200 mL of warm water (60°C), 1 g of salt and 10 g of dietary fiber (galactomannan decomposition product, "Sunfiber R" (manufactured by Taiyo Chemical Co., Ltd.)) are blended (added) to prepare a liquid composition (3a) ). After containing (filling) 200 mL of this liquid composition (3a) in a flexible container made of polyethylene resin, it is subjected to high-pressure steam sterilization (sterilizer sterilization (120°C, 10 minutes)) to prepare a liquid composition ( 3b). Furthermore, the concentration of sodium (Na) is 200 mg/100 mL, and the concentration of chlorine (Cl) is 300 mg/100 mL.

At this time, even if the liquid composition (3b) is stored under specific conditions (40°C, 2 months), it will not cause spoilage or poor flavor. In addition, when the liquid composition (3b) is connected by a pipe to suck up the liquid composition (3b), the liquid composition (3b) is not exposed to the atmosphere, and can hygienic transportation of water, salt, and water. Food fiber.

(Example 4) Formulation example (4) of liquid composition (replenisher)

In 200 mL of warm water (60°C), mix (add) 2 g of table salt and 5 g of dietary fiber (galactomannan decomposition product, "Sunfiber R" (manufactured by Taiyo Chemical Co., Ltd.)) to prepare a liquid composition (4a) ). After storing (filling) 200 mL of this liquid composition (4a) in a flexible container made of polyethylene resin, it is subjected to high-pressure steam sterilization (sterilizer sterilization (120°C, 10 minutes)) to prepare a liquid composition ( 4b). Furthermore, the sodium (Na) concentration is 400 mg/100 mL, and the chlorine (Cl) concentration is 600 mg/100 mL.

At this time, even if the liquid composition (4b) is stored under specific conditions (40°C, 2 months), it will not cause spoilage or poor flavor. In addition, when the liquid composition (4b) is connected by a pipe to suck up the liquid composition (4b), the liquid composition (4b) is not exposed to the atmosphere, and can hygienically transport water, salt, and water. Food fiber.

(Example 5) Formulation example (5) of liquid composition (replenisher)

In 300mL of warm water (60℃), mix (add) 1g salt and 5g dietary fiber (galactomannan decomposition product, "Sunfiber R" (Taiwan (Manufactured by Yang Chemical Co.)) to prepare a liquid composition (5a). After containing (filling) 300 mL of the liquid composition (5a) in a flexible container made of polyethylene resin, it is subjected to high-pressure steam sterilization (sterilizer sterilization (120°C, 10 minutes)) to prepare a liquid composition ( 5b). Furthermore, the concentration of sodium (Na) is 133 mg/100 mL, and the concentration of chlorine (Cl) is 200 mg/100 mL.

At this time, even if the liquid composition (5b) is stored under specific conditions (40°C, 2 months), it will not cause spoilage or poor flavor. In addition, when the liquid composition (5b) is connected by a pipe to suck up the liquid composition (5b), the liquid composition (5b) is not exposed to the atmosphere, and it can transport water, salt, and water hygienically. Food fiber.

By combining two or more liquid compositions (replenishment solutions) of the aforementioned Examples 1 to 5, the mineral components, moisture, and dietary fiber content of the combined replenishment solution can be adjusted to the most appropriate level, which can be rapid and flexible According to the requirements of the medical field, various supplementary liquid prescriptions to cooperate with patients and other cases. The administration method of the nutritional composition and the like using the previous commercial products is set as Comparative Examples 1 to 3, and the administration method of the liquid composition (replenishing liquid) in combination of two or more of the foregoing Examples 1 to 5 is set to implementation Examples 6~8. The comparison results are shown in Table 1.

[Table 1]

Judging from the results shown in Table 1, it can be seen that in the administration methods of Comparative Examples 1 to 3, the addition of salt and dietary fiber occurs for each dose of the nutritional composition prescribed by the patient. And it is necessary to adjust the amount of salt and dietary fiber. In addition, it can be seen that when the converted amount of salt or the content of dietary fiber of the previous product has a decimal, an error will occur between the required amount of the patient's prescription and the dosage.

On the other hand, it can be seen that in the administration methods of Examples 6-8, by combining two or more supplements of Example 1 and Examples 3 to 5, it is possible to simply and quickly prepare nutrition that is completely suitable for the patient’s prescription. Composition.

Claims (9)

A supplement for enteral nutrition, which is composed of mineral components, water and dietary fiber. The aforementioned mineral components include sodium. The sodium content of the supplement is 0.3~26g/100mL in terms of salt. The supplement solution according to claim 1, which further contains vitamin components. The supplement liquid according to claim 1 or 2, wherein the dietary fiber is 0.5 to 15% by weight. The supplement liquid according to claim 1 or 2, wherein the dietary fiber is a guar gum decomposition product or a guar gum hydrolysate. The replenishment liquid according to claim 1 or 2, wherein the total weight of sodium ions and the weight of chloride ions is 80 to 100% by weight relative to the weight of the total mineral components. The replenisher according to claim 1 or 2, wherein the weight of sodium ions is 60 to 200% by weight relative to the weight of chloride ions. A replenisher to be put in a container, which is obtained by heat-sterilizing a container containing the replenisher described in any one of claims 1 to 6. The replenishment liquid put into the container as described in claim 7, wherein the container is a closed type. The replenisher placed in a container according to claim 7 or 8, wherein the container has one or more narrow mouths for outflow and/or mixing.