TW201103430A - Triazole compounds carrying a sulfur substituent XII - Google Patents

Abstract

The present invention relates to novel triazole compounds of the formulae I and II as defined below which carry a sulfur substituent, to agricultural compositions containing them, to their use as fungicides and to intermediate compounds used in the method of producing them.

Description

201103430 VI. OBJECTS OF THE INVENTION: TECHNICAL FIELD The present invention relates to a novel triazole compound of the formula I and II having a sulfur substituent as defined below, comprising an agricultural composition thereof as a fungicidal agent Uses and intermediate compounds used in the method of manufacture thereof. [Prior Art] Prevention and control of plant diseases caused by phytopathogenic fungi is extremely important for achieving high productivity. Plant diseases in ornamental crops, vegetable crops, field crops, alfalfa crops, and fruit crops can significantly reduce productivity, thereby increasing the cost to consumers. The triazole-based derivatives are described in WO 96/41804, WO 96/16048, WO 97/41107, WO 97/43269 and WO 97/44331. These compounds are used against harmful fungi. There is a constant need for a novel compound that is more efficient, less costly, less toxic, safer to the environment, and/or has a different mode of action. SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide compounds having preferred fungicidal activity and/or better crop compatibility. Surprisingly, these objectives are achieved by the triazoles of the formulae I and II as defined below and the agriculturally acceptable salts of the compounds I and II. Accordingly, the present invention relates to triazole compounds of the formulae I and II and their agriculturally applicable salts, 149027.doc 201103430

Where Ar

Het 〇j has 1, 2, 8, 3, 4 or 5 substituents R2 phenyl, or helmet 2 has 1, 2 or 3 selected from N,. And a hetero atom of S as a member of the ring, 3, 4, 5, 6 - 10 1 〇 s - saturated, partially unsaturated or aromatic - wherein the heterocyclic ring may have 1, 2, 3 or 4 substitutions a hetero atom having 1, 2 or 3 selected from N, (d) as a ring, a 3, 4, 5, 6 or 7-membered saturated, partially unsaturated or aromatic R 4 heterocyclic ring wherein the heterocyclic ring Has 1, 2, 3 or 4 substituents

A Y R1 is a 1, 2 -based bridge; 0, S or NR6; is selected from nitrogen, Cl_Cl〇, C Γ1 rfe «. 10 Ll_Ci〇 halogen courtyard, CVC. Alkene =, C2-Cl. The function is dilute, c2_Ci decynyl, C2_c. Teeth, 3 ^(7)cycloalkyl, (: 3-(:10 halocycloalkyl, stupyl, some C4 alkyl, the stupid (four) of the last two mentioned groups; with 1, 2 , 3, 4 or 5 substituents R7, and containing ?, 2 or 3: 5 or 6-membered sigma, partially unsaturated or aromatic heteropoly which are selected from the heteroatoms of ruthenium, osmium and S as ring members a ring wherein the heterocyclic ring may have a linear chain substituted with 3 or 4 substituents R5; {5 extension 149027.doc [S] 201103430 1, 2 or 3 substituents R7; or in the case of m*0, 〇J is selected from the group consisting of -C(=0)R, -C(=S)R8, _s(〇)2r8, _CN, ρ(υ^丨.

among them

Ar, Het, A, and Y are as defined in the formula and # is the point of attachment to the rest of the molecule;

Rla is selected from the group consisting of f, rrh « a alkyl group, Cl_Ci〇_ alkyl, C2_C| fluorene, c2-c1G_group, c2_Ciq fast group, C2_Ciq haloalkynyl group, C^C10 cycloalkyl group, C^Cio Halocycloalkyl 'phenyl, phenyl-Cl-4 group wherein the phenyl moiety of the last two mentioned groups may have 2 3, 4 or 5 substituents R7, containing 1, 2 or 3 a heterocyclic atom of ^ and s as a 5- or 6-membered saturated, unsaturated or aromatic heterocyclic ring of a ring member, wherein the heterocyclic ring may have 1, 2 or 3 substituent base blocks 7, -c (=0) R8, -c(=s)R8, -S(0)2R8, •CN, -P(=Q)R9Ri〇 and Μ; each R is independently selected from the group consisting of ko, OH, SH, N02 , CN, Cl-C4 alkyl, c]-c4_alkyl group c2_c4 alkenyl, C2_C4_thinyl, οι alkynyl, c2-c4 haloalkynyl, c3_c8 cycloalkyl, c3_C8 halocycloalkyl, C ρ Λ- 4* 1丄4 courtyard gas base, Ci-C* haloalkoxy, (^-(:4 olefin 149027.doc 201103430 base, CVC4 haloalkenyloxy, Cl-c4 alkynyloxy, CVC4 haloalkyne Oxy, 〇3-(:8 cycloalkoxy, c3-c8 halocycloalkoxy, cvq thiol, CVC4 haloalkylthio, dG olefinylthio, CVC4 1I thiol'phenyl, phenyl -CVC: 4 alkyl, phenyl-(^-(^ Alkoxy, phenoxy, thiol, wherein the phenyl moiety of the last five mentioned groups may have 1, 2, 3' 4 or 5 substituents 11; contains 1, 2 or 3 a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated heterocyclic ring selected from the group consisting of N, hydrazine and 8 heteroatoms, wherein the heterocyclic ring may have R,COR丨2, c〇〇Ri2, c〇nr13rU, 丨4 and S(0)pR, wherein the aliphatic moiety of the above group may have 1, 2 or 3 substituents Rl5 and wherein the above group The cycloaliphatic moiety may have 1, 2 or 3 substituents Ri6; or the two groups r2 attached to adjacent carbon ring atoms together with the attached carbon ring atom - form part of the unsaturated or maximum unsaturation a 5-, 6- or 7-membered carbocyclic ring or a partially unsaturated or maximally unsaturated 6 or 7. beryllylene ring containing 1, 2 or 3 heteroatom ring members selected from the group consisting of ruthenium and rhodium; wherein the carbon The ring or heterocyclic ring may have or have three substituents Rn; each R is independently selected from the group consisting of halogen, 〇h A SH, N02, CN, C丨-C4 alkane Ci-C4_alkyl, c Γ h block, CC... 2-C4(4), C2·Alkane 2 4 , , C”Cs naphthenes 'C3-C8 halocycloalkyl soil, ci_C4 burn group, C group, Shu -C4 haloalkoxy, C -C4 alkenyloxy Shu

Cl-C4 haloalkenyloxy, Γ Ρ ^ alkynyloxy, c丨-c4 haloacetylene 149027.doc 201103430 base, C3-C8 cycloalkoxy, C3-C8 halocycloalkyloxy, sulfur-burning, CVC4 Haloalkylthio, Cl_c4 disulfide, Ci_c4 alkynylthio, phenyl, phenyl-Cl-C4 alkyl, phenyl_C_c4 alkoxy, phenoxy, phenylthio, of which the last five The phenyl moiety in the group mentioned may have 1, 2, 3, 4 or 5 substituents Ri 1 ; 3 - 3 or 3 heteroatoms selected from N, oxime and S as ring members , 4_, 5_, 6- or 1 2 3 4 4_membered saturated, partially unsaturated or most unsaturated heterocyclic ring 'where the heterocyclic ring can have! , 2 or 3 substituents R1 丨; COR! 2, COORi2, c〇nr13r14, 丨, 丨 4: S(0)pR12, wherein the aliphatic moiety of the above group may have u or 3 substituents R15 And wherein the cycloaliphatic moiety in the above-mentioned /, T-back violent group may have 1, 2 or 3 substituents R»5; or attached to (heterocyclic Ar) adjacent ring 屌+卜+工, state The two groups R3 on the enamel together with the ring atom to which they are attached are shaped, and the salty partially unsaturated or maximally unsaturated 5-, 5- or 1-member carbon ring or contains 2 or 3 a hetero atom of 〇, ^N as a ring member, a partially unsaturated 戍 maximally unsaturated 5-' 6- or 7-membered heterocyclic ring; a dansylamine or a heterocyclic ring may have 1, 2 or 3 substituents R11 ;

Each R has its NVJ2 ' CN ' group on rr, alkyl group, C2_C4 group-based r ^ self-alkenyl group, C2- 4 alkynyl group, c2-c4 halogen block group, C3_c ^ ur, ^ pit group, C3_C8 halogen ring fluorenyl group , alkoxy, I49027.doc 1 丞Cl-C4 haloalkenyloxy, C丨-c4 alkyneoxy* 2 2 P 4 alkynyloxy, c,-c4 decyneoxy 3, C3-C8 cycloalkoxy Base, c3_c _ 4 alkoxy, c丨-c4 alkane 5 > C Γ ^ ^ ^ thiol, C,-C4 olefin oxygen 201103430 thio, (^-(: 4_alkylthio, Ci_C4 sulfur a base, a Ci_C4 alkynylthio group, a phenyl group, a phenyl-Cl_C4 alkyl group, a phenyl-Ci_c4 alkoxy group, a phenoxy group, a phenylthio group, wherein the phenyl moiety in the last five mentioned groups may have 1, 2, 3, 4 or 5 substituents Ru; 3-, 4, 5...6_ or 7_members saturated with 1, 2 or 3 heteroatoms selected from N, 〇 and 8 as ring members a partially unsaturated or a maximum unsaturated heterocyclic ring wherein the heterocyclic ring may have 1, 2 or 3 substituents R"; COR12, CO〇R, 2, c〇nr13rM dish 13ri4 and S(0)PR, wherein The aliphatic moiety in the group may have 丄, 2 or 3 substituents m wherein the cycloaliphatic moiety of the above group may have 1, 2 or 3 substitutions r;6; or two groups r4 attached to an adjacent ring atom of (Het) together with the ring atom to which they are attached form a partially non-filament or maximum unsaturated 5-, 6- or 7-member carbon ring Or a partially unsaturated or maximally unsaturated 5- or 6- or 7-membered heterocyclic ring containing hydrazine, 2 or 3 heteroatoms selected from the group consisting of hydrazine, § and N; wherein the carbocyclic or heterocyclic ring may have 1, 2 or 3 substituents Rn; each R is independently selected from the group consisting of halogen, hydrazine H, SH ' nr13r14, alkyl, cam group, C2_C4 dilute group, C2_c碯 dilute group, & ^ fast radical, C2-C4 letter Alkynyl, c, -c4 alkoxy, Ci_C4 functional alkoxy, eve:4 alkylthio and Ci_C4_alkylthio, wherein the aliphatic moiety of the above group may have an anthracene, 2 or 3 substituents... 5; or two groups R5 attached to two adjacent carbon atoms together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7_

[SI 149027.doc 201103430 and 3, 4, 4, %, 6 or 7-members, partially unsaturated or maximally unsaturated carbocyclic or containing 丨' 2, or 3 heteroatoms selected from 〇·, as ring members a saturated, partially unsaturated or maximum unsaturated heterocyclic ring wherein the carbocyclic or heterocyclic ring may have 丨' 2 or 3 substituents R11; R6 is selected from the group consisting of hydrogen, CN, Γr ρ a threshold N Cl-C4 Base, C丨-C4IS alkyl, c2_c4 alkenyl, C2-C4 alkenyl, c2_c4, C2_C, fast, oxy, Cl_c, alkoxy, phenyl, phenyl, the last two The phenyl moiety in the reference group may have CONR13R丨4 and s(〇)pRi2; each R7 is independently selected from the group consisting of dentate, 〇h, sh, nr13r14, cn n〇2, I c4, and c2_c4 ^, c2_Cj alkenyl, c2-c4 alkynyl, c4 haloalkoxy, R15 in the above group in c; C2-C4 haloalkynyl, cvc4 alkoxy, (V 1-C4 alkylthio & Cl_c4 haloalkylthio, the aliphatic moiety of which may have 1, 2 or 3 substituents r! k from hydrogen, CVCw appearance group, Ci_Ci〇-alkyl, alkoxy 'CrC“ alkoxy, Ci_Ci fluorenyl Calcination, C3_C1. Cycloalkyl, C3-Cl. Cycloalkyl, benzene The phenyl moiety of the phenyl(tetra)alkyl group wherein the last two of the groups mentioned may have 1 2 3 4 or 5 substituents R7, containing fluorene, 2 or 3 heteroatoms selected from the group consisting of ruthenium and osmium. a saturated or partially unsaturated or aromatic heterocyclic ring as a ring member, wherein the heterocyclic ring may have a substituent 2 or 3 149027.doc 201103430 substituents R7, and NR13R14; R9 and R10 are independently selected from the group consisting of cvcw Alkyl, Cl_Ci〇 haloalkyl, C2_c10 dilute, C2-Ci〇_ dilute, C2-C10 block, C2-C10 haloalkynyl, eve!. cyclodextrin: c, c3-c1Qii cycloalkyl, Ci_c10 methoxy, Ci-Cio halooxy, Ci-C^ alkoxy_Cl_c10 alkyl, Ci-C4 alkoxy-Ci-Cio alkoxy, (^-(^. thiol, Ci -Ci〇ii, sulfur-based, C2-C1G-alkenyloxy, c2-C1G-alkenylthio, C2-indole10-alkynyloxy, C2-C1()alkynylthio, c3-C1()cycloalkoxy, c3 -Ciocycloalkylthio, phenyl, phenyl-c丨-c4 alkyl, phenylthio, phenyl-CVC4 alkoxy and NR13R14; each R丨1 is independently selected from the group consisting of halogen, OH, SH, NR13R丨4. CN, N02, (VC4 alkyl, C丨-C4 li, c2_c4 alkenyl, c2_c4_alkenyl, C2-C4 alkynyl, c2-c4 haloalkynyl, alkoxy a group, (ν(:4ι| alkoxy, Ci-C^sulfuryl and Ci_c4_alkylthio), wherein the aliphatic moiety in the above group may have 1, 2 or 3 substituents R15; each R12 is independent Selected from hydrogen, Cl_c4 alkyl, Ci_c4_alkyl, c2_c4 alkenyl, CrC4 haloalkenyl, CVC4 aminoalkyl, phenyl, phenyl-C^C4 alkyl, of which the last two mentioned groups The phenyl moiety in the phenyl moiety may have 1, 2, 3, 4 or 5 substituents, and 5, or 6-members containing 1, 2 or 3 heteroatoms selected from N, oxime and S as ring members. a saturated, partially unsaturated or aromatic heterocyclic ring wherein the heterocyclic ring may have 1, 2 or 3 substituents R"; each R13 is independently selected from hydrogen & Cl-c8 alkyl;

[SI 149027.doc -10· 201103430 Each R14 is independently selected from the group consisting of hydrogen, CVCs alkyl, phenyl and phenyl-(^-alkenyl; or R13 and R14 together form a straight chain (^ or ... alkyl) Bridge or group -CH2CH2OCH2CH2- or -CH2CH2NR17CH2CH2-; each R]5 is independently selected from the group consisting of nitro, CN, OH, SH, COR12, COOR12, c〇NR13R14; NR13R14, c3-c6 cycloalkyl, C3-C6 halogen a cycloalkyl group, a CVC4 alkoxy group, a (:,-04 haloalkoxy group, a fluorene 3-0^6 ring alkoxy group (CyCi〇ai〇Xy), a phenyl group and a phenoxy group; each R16 is independently selected from the group consisting of Nitro, CN, 〇H, SH, COR12, coor12, C0NRnRl4, NR" Rl4, Ci_c4 alkyl, Ci_C4i alkyl, (: 3-(:6 cycloalkyl, c3-c6 halocycloalkyl, cvc4 Oxyl, (VC4 haloalkoxy, c3-C6 cycloalkoxy, phenyl and phenoxy; each R17 is independently selected from hydrogen and (:1_(:4 alkyl; Q is 〇 or s; M is a metal cation equivalent or an ammonium cation of the formula (NRaRbRcRd)+, wherein Ra, Rb '1^ and Rd are independently of each other selected from the group consisting of hydrogen, CI0 alkyl, phenyl and benzyl, of which the last two are mentioned in the group The phenyl moiety may have 1, 2 or 3 substituents independently selected from the group consisting of -N, CN, nitro, Cl-C4 alkyl, Cl_C4_alkyl, G-C4 alkoxy, Cl_C4 haloalkoxy and NRi3Ri4; m is 〇, 1 or 2; and P is 1 or 2. The invention also provides the use of the formula I and the oxatriazole compound and/or its agriculturally useful salt 149027.doc 201103430 for controlling harmful fungi. The invention further provides for the inclusion of the formula 丨 and/or ^ (also and/or Formula ιν; see below) Triazole compounds and/or agriculturally acceptable salts thereof and fungicidal compositions suitable for carriers. Suitable agriculturally acceptable carriers are described below. Compounds I and II may be one or more Stereoisomers exist. The various stereoisomers include enantiomers, diastereomers, atropisomers (atr〇p1SOmers) and geometric isomers. Those skilled in the art will appreciate that When the stereoisomers are concentrated relative to other stereoisomers or when separated from other stereoisomers, they may be more active and/or may exhibit beneficial effects. In addition, the skilled practitioner knows how to Separating, enriching and/or selectively preparing the stereoisomers. The compounds of the invention may It is now a mixture of stereoisomers (such as racemates), individual stereoisomers or optically active forms. It should be understood that the compounds! and „ can be mutually positional/double bond isomers, at least in the same group RVW In the case of In the case where R1 (and of course Rla) is hydrogen, the respective compounds I and II are tautomers. Suitable agriculturally useful salts are, in particular, salts of cations or acid addition salts of acids. The cations and anions, respectively, have no adverse effect on the fungicidal action of the compound. Therefore, suitable cationic cations are especially alkali metal ions, preferably neutralized ions; soil metal ions, preferably m钡 ions; and transition metal ions, preferably clocks, zinc and iron ions; And a sulphur ion (if necessary, it may have 1 to 4 CVC4 alkyl substituents and (4) phenyl or a sulfhydryl substituent) 'Cardipine diisopropylammonium, tetramethylammonium 149027.doc 201103430 ammonium, trimethylbenzyl Ammonium; in addition, 'scale ions, barium ions, preferably three (Ci c4 alkyl) sparse' and sulfoxonium ions, preferably three (c丨_c4 burnt) cerium oxide. Useful anion of acid addition salt is mainly chloride ion, bromide ion, gas ion, hydrogen sulfate, sulfate, dihydrogen phosphate, hydrogen hydride, acidate, nitrate, bicarbonate, carbonate, The hexafluoroantimonate, hexafluororesidate, benzoate, and the anion of the C1-C4 alkanoic acid are preferably decanoate, acetate, propionate and butyrate. It may be formed by reacting I or hydrazine with an acid of the corresponding anion, preferably hydrochloric acid, hydrobromic acid, sulfuric acid, acid or nitric acid. In the definition of the variables given in the above formula, generally representative collective terms are used for the substituents in question. The term Cn-Cm denotes the number of possible carbon atoms in each case in the substituent or substituent moiety in question. Halogen: fluorine, gas, bromine and iodine; alkyl and alkoxy, alkoxyalkyl, alkoxyalkoxy, alkylcarbonyl, alkylthiocarbonyl, aminoalkyl, alkylamino, two Alkyl moiety in alkylamino, alkylaminocarbonyl, dialkylaminocarbonyl, alkylthio, alkylsulfonyl and the like: having 1 to 2 alkyl groups, 2 or 3 (C2-C3 alkyl), 1 to 4 ((CVC4 alkyl), 1 to 6 (CVC6 alkyl), 1 to 8 (CrCs alkyl) or 1 to 1 (CfCw alkyl) carbon a saturated linear or branched hydrocarbon group of an atom. The C2-C3 alkyl group is an ethyl group, a n-propyl group or an isopropyl group. The C2 alkyl group is a mercapto group or an ethyl group. The alkyl group is a mercapto group, an ethyl group, a propyl group or a different group. Propyl, butyl, 1-methylpropyl (second butyl), 2-methylpropyl (isobutyl) or 1,1-dimethylethyl (t-butyl Cl-C6 alkyl Further, for example, pentyl, 1-mercaptobutyl, 2-mercaptobutyl, 3-methylbutyl, 2,2-di 149027.doc -13-201103430 methylpropyl, 1-B Propyl, u-dimethylpropyl, U dimethylpropyl, hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methyl Pentyl, 1,1-dimethylbutyl, anthracene, 2-dimethylbutyl, hydrazine 3 dimethylbutyl, 2,2-dimethylbutyl' 2,3-dimethylbutyl Base, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, u, 2-trimethylpropyl, trimethylpropyl, 1-ethyl-1-anthracene The propyl group or the ethyl 2-methylpropyl group. The ei_c8 alkyl group is also additionally, for example, heptyl, octyl, 2-ethylhexyl and positional isomers thereof. The CrCw alkyl group is additionally (for example) a mercapto group, a mercapto group, a 2-propylheptyl group, a 3-propylheptyl group, and a positional isomer thereof. Haloalkyl group: having 1 to 2 (CVC2 haloalkyl), one (Ci_C3 haloalkyl), 1 to 4 (C--C4 functional base), 1 to 6 ((:,-(:6), 1 to 8 (Ci-Cg self-burning), 1 to 1 halogen) a linear or branched alkyl group of 2 to 1 (c2-C10 haloalkyl) carbon atom (as described above), wherein some or all of the hydrogen atoms of such groups may be as described above Halogen atom replacement. In detail, it is a Ci-C2 halogen group, such as gas sulfhydryl, desert sulfhydryl, dihalohydrazino, trimethyl fluorenyl, fluoroindolyl, difluoromethyl, trifluoromethyl, chloro fluorine Sulfhydryl, dioxin, fluorinated fluorenyl, 1-fluoroethyl, 1-methylidene, 1_fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2 ,2-trifluoroethyl, 2-gas-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-di-gas-2-fluoroethyl, 2,2,2- Di-ethyl or penta-ethyl. The C1-C3 halo group is additionally (for example, trifluoropropan-2-yl, 3,3,3-trifluoropropyl or heptafluoropropyl. The radical is additionally, for example, 1-chlorobutyl, 2-oxobutyl, 3-oxobutyl or 4-oxobutyl.

Ci-C1 () hydroxyalkyl group: having 1 to 2 (C 〗 - C 2 hydroxy groups), 1 to 4 (C) - C4 burned base, 2 to 4 (C2-C4 burned) 1 to 6 burned

L SI 149027.doc • 14· 201103430 base), 2 to 6 (C2-C6 burned base), uwC〗-c8 via hospital base), 2 to 8 (C2-C8 burned base), 1 to 10 (Cl_Cl〇M) or 2 to 1 (C2_Cl〇 light alkyl) carbon or a linear or branched alkyl group (as described above), wherein at least one of the II atoms is replaced by a substituent, such as 2- Hydroxyethyl or 3-propyl. Alkenyl moiety in alkenyl and alkenyloxy, alkenylthio, alkenylcarbonyl and the like: having 2 to 4 (C2-C4 alkenyl), 2 to 6 (C2-C6 alkenyl), 2 Up to 8 (C2-C8 dilute), 3 to 8 (C3-C8 alkenyl), 2 to 10 (C2-C10 dilute) or 3 to 10 (C3-C|G dilute) carbon atoms And a monounsaturated linear or branched hydrocarbon group having a double bond at an arbitrary position, for example, a C2_C4 alkenyl group such as a vinyl group, a 1-propenyl group, a 2-propenyl group, a 1-methylvinyl group, a fluorene-butene group Base, 2-butenyl, 3-butenyl, 1-indenyl-i-propenyl, 2-methyl-hydrazine-propenyl, 1-mercapto-2-propenyl or 2-methyl-2- Propylene group, or for example, c2_c6^ group such as vinyl, 1-propenyl, 2-propenyl, iota methyl, 1-butenyl, 2-butenyl, 3-butenyl, ι _mercaptopropenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3- Pentenyl, 4-pentenyl, 1-methyl-i-butenyl, 2-mercapto-1-butenyl, 3-mercapto-i-butenyl, indolyl-2-butenyl, 2- Mercapto-2-butenyl, 3-mercapto-2-butenyl, 1- Mercapto-3-butenyl, 2-mercapto-3-butenyl, 3-methyl-3-butenyl, anthracene, 1-difluorenyl-2-propenyl, 1,2-dioxin 1-propenyl, 1,2-diindenyl-2-propenyl, oxime-ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexene , 3-hexenyl, 4-hexenyl, 5-hexenyl, i-methyl-hydrazine-pentenyl, 2-hydrazino-1-pentenyl, 3-mercapto-1-pentyl Alkenyl, 4-methyl-1-pentenyl, 1-hydrazino-2-pentenyl, 2-mercapto-2-pentenyl, 3-mercapto-2-pentenyl, 4-fluorenyl -2- 149027.doc -15· 201103430 Pentenyl, 1-mercapto-3-pentenyl, 2-methyl-3-pentenyl, 3-mercapto-3-indolyl, 4-mercapto _3-pentenyl, 1-decyl_4-pentenyl, 2-hydrazino-4-pentenyl, 3-methyl-4-pentenyl, 4-mercapto-4-pentenyl, M_dimercapto-2-butenyl, 1,1-diindenyl-3-butenyl, indenyl]butenyl, 1,2-dimethyl-2-butenyl, ι,2-dimethyl-3-butenyl, dimethyl-1-butenyl, 1,3-didecyl-2-butenyl, 1,3-dimethyl-3-butene Base, 2'2-mercapto-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-diindenyl-2-butene , 2,3-dimethyl-3-butenyl, 3,3-diindolyl q•butenyl, 3,3-indenyl-2-butenyl' 1_ethyl_ι_ Dilute, 丨_ethyl_2_butenyl, 1-ethyl-3-butenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl 3-butenyl, H2-trimethyl-2-propenyl, 丨_ethyl_1β decyl-2-propenyl, 丨_ethyl_2_methyl_丨_propenyl' 丨_B Base 2 fluorenyl-2-propenyl and analogs thereof; alkenyl group in the alkenyl group and the i-alkenyloxy group, the alkenylcarbonyl group and the like: having 2 to 4 (C2-C4 halogenated alkene) Base), 2 to 6 (C2-C6 haloalkenyl), 2 to 8 (C2-C8-alkenyl) or 2 to 10 (C2-C1()-alkenyl) carbon atoms and at any position a double-bonded unsaturated linear or branched hydrocarbon group (as described above) wherein some or all of the hydrogen atoms of such groups may be replaced by a halogen atom (especially fluorine, gas and bromine) as described above, such as Vinyl, allylic, and the like; alkynyl moiety in alkynyl and alkynyloxy, alkynylthio, alkynylcarbonyl, and the like: having 2 to 4 (C2-C4 alkynyl), 2 Up to 6 (C2-C6 alkynyl), 2 to 8 (C2-C8 alkynyl), 3 to 8 (C3-C8 alkynyl), 2 to 10 (C2-C1G alkynyl) or 3 to 1 fluorene (c3-C 1 decynyl) Carbon atom and one or two at any position [S] I49027.doc -16· 201103430 A direct bond or a bond group of a bond, such as 'C2-C4 fast group' such as ethynyl, 1-propynyl , 2-propynyl, 1-butynyl, 2-butynyl, 3-butenyl or 1-methyl-2-propanyl, or, for example, C2-C6 alkynyl, such as an alkenyl group, 1-propynyl, 2-propynyl '1-butynyl' 2-butynyl' 3-butynyl, 1-indolyl-2-propanyl, 1-pentyl, 2-indole Block group, 3-pentenyl group, 4-pentynyl group, 1-mercapto-2-butynyl group, 1-methyl-3-butynyl group, 2-mercapto-3-butynyl group, 3- Mercapto-1-butynyl, 1,1-dimercapto-2-propynyl, 1-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexyne , 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-mercapto-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl 3-pentynyl, 2-mercapto-4-pentynyl, 3-mercapto-1-pentynyl, 3-methyl-4-pentynyl, 4-mercapto-1-pentyne Base, 4-methyl-2-pentynyl, 1,1-di 2-butynyl, 1,1-dimercapto-3-butynyl, 1,2-dimercapto-3-butynyl, 2,2-dimethyl-3-butynyl, 3 ,3-dimethyl-1-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl, 1-ethyl 1-methyl-2-propanyl and the like; alkynyl moiety in alkynyl and ynkynyloxy, ynkynylcarbonyl and the like: having 2 to 4 (CVC4 haloalkynyl) ), 2 to 6 (C2-C6 haloalkynyl), 2 to 8 (C2-C8 tooth fast radical) or 2 to 10 (C2-Clf) iS alkynyl) carbon atoms and one or two in any a non-saturated linear or branched hydrocarbon group at a position (as described above) wherein some or all of the hydrogen atoms of the groups may be replaced by a halogen atom (especially fluorine, gas and bromine) as described above; a cycloalkyl moiety in a cycloalkyl group and a cycloalkyloxy group, a cycloalkylcarbonyl group, and the like. It has 3 to 6 (Cs-C: 6 cycloalkyl groups) and 3 to 8 (C3_C8 cycloalkyl groups). Or a monocyclic saturated hydrocarbon group of 3 to 10 (C3_C1Q cycloalkyl)carbocyclic members, such as 149027.doc • 17-201103430 cyclooctyl, cyclocyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl , cycloheptyl fluorenyl and cyclodecyl; i-cycloalkyl moiety of halocycloalkyl and halocycloalkoxy, cycloalkylcarbonyl and the like: having 3 to 6 (CrC6 halocycloalkyl) a monocyclic saturated hydrocarbon group of 3 to 8 C8 functional cycloalkyl) or 3 to _(C3_Ci〇_cyclohexyl) carbocyclic ring members (as described above), wherein some or all of the hydrogen atoms may be as described above Substitution of a halogen atom (especially fluorine, gas, and bromine); a ring-based moiety in a cycloaliphatic group and a cycloalkenyloxy group, a ring-like base, and the like: having 3 to 6 (C3-C6 cycloalkenyl groups), a monocyclic monounsaturated hydrocarbon group of π, %% cycloaliphatic) or 3 to 10 (C3-C1G cycloalkenyl) carbocyclic members, such as cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexene a group: a heptyl group, a cyclooctenyl group, a cyclodecenyl group, and a cyclodecenyl group; a halocycloalkenyl group of a ring cycloalkenyl group and a ring cycloalkenyloxy group, a halocycloalkenylcarbonyl group, and the like: Monocyclic ring having 3 to 6 ((:3_(:61|cycloalkenyl)), 3 to 8 (C3_C8 halocycloalkenyl) or 3 to 10 (C3_Cl〇 halocycloalkenyl) carbon ring members Unsaturated hydrocarbon groups (as described above) 'some of them or There may be a hydrogen atom as a halogen atom (especially fluorine, bromine and gas) of the displacement;

CrC6 cycloalkyl-C,-C2 alkyl: a Ci_c2 alkyl residue as described above wherein one hydrogen atom is replaced by a C3-C6 cycloalkyl group. Examples are cyclopropylindenyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, cyclopropyl-ethyl, cyclobutyl-1-ethyl, cyclopentyl-indole-ethyl, cyclohexyl.丨_Ethylcyclopropyl-2-ethyl, cyclobutyl-2-ethyl, cyclopentyl-2-ethylcyclohexyl-2-ethyl and the like. The C3_Ci〇cycloalkyl-C1-C4 alkyl group is a q-c:4 alkyl residue as described above in which one hydrogen atom is replaced by a C3_Cig cycloalkyl group. In addition to the groups mentioned above by [149027.doc -18· 201103430, examples of C3-C6 cycloalkyl-Ci-CU alkyl are also cycloheptyldecyl 'cyclooctylfluorenyl, ring. Indolyl, cyclodecylmethyl, cycloheptyl-1-ethyl, cyclooctyl-1-ethyl, cyclodecyl-i-ethyl, cyclodecyl-1-ethyl, cycloheptyl -2-ethyl, cyclooctyl-2-ethyl, cyclodecyl-2-ethyl, cyclodecyl-2-ethyl, cyclopropyl-1-propyl, cyclopropyl-2-propyl , cyclopropyl-3-propyl, cyclobutyl-1-propyl, cyclobutyl-2-propyl, cyclobutyl-3-propyl, cyclopentyl-1-propyl, cyclopentyl_ 2-propyl, cyclopentyl-3-propyl, cyclohexyl-1-propyl, cyclohexyl-2-propyl, cyclohexyl-3-propyl, cycloheptyl-1-propyl, phosphinyl -2-propyl, cycloheptyl-3-propyl, cyclooctyl-1-propyl, cyclooctyl-2-propyl, cyclooctyl-3-propyl, cyclodecyl-1-propyl , cyclodecyl-2-propyl, cyclodecyl-3-propyl, cyclodecyl-1-propyl, cyclodecyl-2-propyl, cyclodecyl-3-propyl, cyclopropyl- 1-butyl, cyclopropyl-2-butyl, cyclopropyl-3-butyl, cyclopropyl-4-butyl, cyclobutyl-1-butyl, cyclobutyl-2-butyl, ring Butyl-3-butyl, cyclobutyl-4-butyl, cyclopentyl-1_butyl, cyclopentyl-2-butyl, cyclopentyl-3-butyl, cyclopentyl-4-butyl Base, % hexyl-1-butyl, decyl-2-butyl, cyclohexyl-3-butyl, cyclohexyl-4-cyclobutyl, cycloheptyl-1-butyl, cycloheptyl-2-butyl Base, cycloheptyl_3_butyl, cycloheptyl-4-butyl, cyclooctyl-1-butyl, cyclooctyl-2-butyl, cyclooctyl-3-butyl, cyclooctyl -4-butyl, cyclodecyl-1-butyl, cyclodecyl-2-butyl, cyclodecyl-3-butyl, cyclodecyl-4-butyl, cyclodecylbutyl, cyclodecyl -2-butyl, cyclodecyl-3-butyl, cyclodecyl-4-butyl and the like 0. Cycloalkyl-Ci-C2 alkyl: Ci-C as described above One of the hydrogen atoms is replaced by a CrC6 halocycloalkyl group. An example is 丨_ 氯琴149027.doc •19· 201103430 propylmethyl, ι·cyclocyclobutylmethyl, chlorocyclopentylmethyl' chlorocyclohexylmethyl, 1 decyclopropylethyl, i 'Air ring butyl small ethyl, Buqi cyclodecyl small ethyl, 1-cyclohexyl small ethyl, i• gas cyclopropyl 2 · ethyl, k gas cyclobutyl ethyl, i' Chlorocyclopentylethyl, cyclohexanecyclohexylethyl, chlorocyclopropylmethyl, 2-cyclopentylmethyl, 2-chlorocyclopentylmethyl, 2-cyclohexylmethyl, 2-v ring Propyl + ethyl, 2' chlorocyclobutyl ethyl, 2-cyclopentyl-ethyl, 2-chlorocyclohexyl + ethyl, cyclohexane propyl 2-ethyl, 2-cyclohexane -2 - ethyl, 2 - gas cyclopentyl 2 - ethyl, 2 - cyclohexyl-2-ethyl, flufen cyclopropyl decyl, "fluorocyclobutyl methyl, fluorocyclopentylmethyl , fluorocyclohexylmethyl, κ fluorocyclopropyl]-ethyl, benzocyclobutyl-rethyl, phenoxycyclopentylethyl, b-cyclohexyl-ethyl, 1-fluorocyclopropyl -2-ethyl, 1-fluorocyclobutyl 2-ethyl, hydrazine-fluorocyclopentyl-2-ethyl, fluorocyclohexyl 2-ethyl, 2-fluorocyclopropyl fluorenyl, fluorine Cyclobutyl , 2-fluorocyclopentylmethyl, 2-fluorocyclohexylmethyl, 2-fluorocyclopropyl-1-ethyl, 2-fluorocyclobutyl-1-ethyl, 2-fluorocyclopentyl-丨· Ethyl, 2-fluorocyclohexyl-1-ethyl, 2-fluorocyclopropyl-2-ethyl, 2-fluorocyclobutyl-2-ethyl, pentyl-2-ethyl, 2- Cyclohexyl-2-ethyl and the like. Cs-C丨〇halocyclohexyl 1 _c丨-C4 alkyl is a CrC4 alkyl residue as described above, wherein one hydrogen atom is (: 3-( : 10 halocycloalkyl substitution. Alkoxy: an alkyl group attached via an oxygen. C^-C: 2 alkoxy is methoxy or ethoxy. C1-C3 alkoxy is additionally (for example) n-propyl Oxy or 1-mercaptoethoxy (isopropoxy). Ci-C: 4 alkoxy is additionally, for example, butoxy, 丨-methylpropoxy (second butoxy), 2 -methylpropoxy (isobutoxy) or 151-didecylethoxy (t-butoxy). C^-C: 6 alkoxy is additionally (for example) pentoxide

[SI 149027.doc -20- 201103430 base 1-methylbutoxy, 2-methylbutoxy, 3-mercaptobutoxy, u

Dimethylpropoxy, U·dimercaptopropoxy, 2,2-dimethylpropoxy, L ethylpropoxy, hexyloxy, 丨-methylpentyloxy, 2-methyl Pentyloxy, 3·decylpentyloxy, 4-methylpentyloxy, 1,1-di-f-butoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutyl Oxy, 2,2-dimethylbutoxy, 2,3-didecylbutoxy, 3,3-dimercaptobutoxy, bethylbutoxy, 2-ethylbutoxy, 1 1,2-trimercaptopropoxy, hydrazine, 2,2•tridecylpropoxy, hydrazine-ethyl-1-methylpropoxy or phenylethyl-2-methylpropoxy. The C1_C8 alkoxy group is, for example, a heptyloxy group, an octyloxy group, a 2-ethylhexyloxy group, and a positional isomer thereof. The Ci-C1Q alkoxy group is additionally, for example, a decyloxy group, a decyloxy group and a position thereof. The structure C2-C1G alkoxy group is similar to a methoxy group, except for a methoxy group. The alkoxy group, which is preferably partially or completely substituted by fluorine, fluorine, gas, bromine and/or iodine. Ci_C2 haloalkoxy is, for example, 〇CH2F, 0CHF2, 〇CF3, 0CH2a, 〇CHCl2, 〇ccl3 , fluorofluoromethoxy, difluorofluoromethoxy, chlorodifluoromethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2-bromoethoxy, 2-iodoethoxy, 2, 2_Difluoroethoxy, 2.2.2-trifluoroethoxy, 2_gas_2•fluoroethoxy, 2•gas_2,2-difluoroethoxy, 2,2-dichloro- 2-fluoroethoxy, 2,2,2-trioxalyl or hydrazine C2F5. qc: 4-haloalkoxy is additionally, for example, 2-fluoropropoxy, 3-fluoropropoxy, 2.2- Fluoropropoxy, 2,3-difluoropropoxy, 2-propyloxy, %-propoxy, 2,3-dipropoxy, 2-bromopropoxy, 3-bromopropoxy Base, 3,3,3_trifluoropropoxy, 3,3,3-dichloropropoxy, 〇ch2-C2F5, 〇CF2-C2F5, l-(CH2F)-2-f-ethylidene, Winter ethoxy, Bu Yang thorn · 149027.doc 21 - 201103430 2-Bromoethoxy, 4-fluorobutoxy, 4-chlorobutoxy, 4-bromobutoxy or nona-butoxy" alkoxy is additionally, for example, 5-fluoropentyloxy 5_ gas pentyloxy, 5-indolyloxy, 5-mothyloxy, undecylpentyloxy, 6-cyclohexyloxy, 6-chlorohexyloxy, 6-bromohexyloxy, 6 iodohexyloxy or dodecafluorohexyloxy. Dilute oxy: a dilute group as described above attached via an oxygen atom, for example, a C 2 —Cl G alkenyloxy group such as an anthracene-vinyloxy group, a 1-propenyloxy group, 2 - propyleneoxy, 1-methylethyloxyoxy, 1 · butyl and butenyloxy, 2-butenyloxy, 3-butenyloxy, !-methyl-i-propenyloxy , 2_Methyl propyleneoxy, i•methyl _ 2-propoxyoxy, 2·methyl 2 _ _ _ oxyoxy, 2 戍 diloxy, % pentyloxy , 4_pentamethoxy, benzyloxybutenyloxy, decenyloxy, 3·methyl oligoyloxy, "yl-2-butanoxyoxydi-methyl-2-butene Oxy, 3·methyl 2_butenyloxy, methylbutoxyoxy, 2-indolyl-3·butyl, knee g μ, Tian I. / Dic acid, 3_methyl·3· Butyl, U-dipropylene 'i-Ethyl-1_propenyloxy, metasoil_2_ diloxy, hexyloxy, hexyl; oxy group, 1_hexg, «, alkenyloxy, 4-hexenyloxy , 5-hexenyloxy ' 1-indenyl-1-pentenyloxy, 2 ! Λ ^ ^ T-yl 1-nonenyloxy, 3-indenyl--indenyloxy, 4-indenyl Small pentyloxy, b-methyl-2-pentenyloxy, 3-methyl-organic-yl-yl-pentenyloxy, fluorenyl-1 pentyloxypentenyloxy, 4-methyl-3- Penteneoxy, 'yl 3 decyl · 3 _ pentyleneoxy, yl = oxoindolyl, iminyl, & diterpene... diloxy, I: yl: pentene oxime ,1·monomethyl-3-butenyloxy, 149027.doc -22- 201103430 1 '2 - — f butyl succinyl A-3-butyl glucomannyl_2~butoxy, two soil _ soil, 1,3-dimethyl-1-butenyloxy, 1,3-dimethylhydrazine) butyloxy, i,3-dimethyl-3-butenyloxy 2,2 m butyl; V group, 2,3-di, _ _ _ _ _ olefin oxy dimethyl ... bis ' yl butyl ethoxy group, A? ^, 3,3. dimethyl]-butanyloxy, 3,3-indole;::oxy, -1-dioxy, "ethyl~ s-ethyl-3-butenyloxy, 2_ethylbutenyloxy, 2butyloxy, 2-ethyl-3-ylbutenyloxy, u,2_methyl-2-propenyloxy: 'Buethyl-1-methyl-2-propene Oxyl, i-ethyl 2 -methyl + apropyloxy and 1-ethyl-2-methyl-2-propenyloxy and the like; _oxy: a diloxy group as described above, It is preferably partially or completely substituted by fluorine, chlorine, and hydrazine. 2 alkynyloxy: an alkynyl group as described above attached via an oxygen atom, for example, a C2-C1()alkynyl group, such as 2_ Propynyloxy, 2-butynyloxy, butynyloxy, 1-methyl-2-propynyloxy, 2-pentynyloxy, 3-pentynyloxy, 4-pentynyloxy, 1-mercapto-2-butynyloxy, 1-hydrazino-3-butynyloxy, 2-methyl-3-butynyloxy, i-ethyl-2-propynyloxy, 2_hexyl Alkynyloxy-p-hexynyloxy, 4-hexynyloxy, 5-hexynyloxy, fluorenyl-hydrazino-2-pentynyloxy, i-decyl-3-pentynyloxy and the like ; alkynyloxy- _ alkynyloxy group as described above, which is preferably fluorine-containing, fluorine, gas, and hydrazine iodine Partially or completely substituted. Cyclophilic oxy group: a cycloalkyl group as described above attached via an oxygen atom, such as 'C3-C1Q cycloalkoxy or CyC8 cycloalkoxy, such as cyclopropoxy, cyclopentyloxy , cyclohexyloxy, cycloheptyloxy, cyclooctyl, cyclodecyloxy, ring U9027.doc • 23· 201103430 decyloxy and its analogues; dentate alkoxy: cycloalkoxy as described above, Its chloroform, chlorine, and/or hydrazine is preferably partially or completely substituted by fluorine. Cycloalkenyloxy: a cycloaliphatic group as described above attached via an oxygen atom, for example, a C3-C1G cycloalkenyloxy group, cvc : 8 cycloalkenyloxy or preferably, cycloalkenyloxy, such as cyclopent-1-enyloxy, cyclopent-2-enyloxy, cyclohexyl and cyclohex-2-enyloxy; Base: an alkyl group as defined above having from 1 to 10, from 1, to 6 or from 1 to 4, especially from 1 to 3, carbon atoms, wherein one hydrogen atom has from 1 to 8, from 1 to 6 Substituted by alkoxy groups of 1 to 4 or up to 3 carbon atoms, for example, methoxymethyl, 2-methoxyethyl, ethoxyoxy, 3-methoxypropyl, 3- Ethoxypropyl and its analogues. Alkoxy group: an alkoxy group as defined above having 1 to 10, 1 to 8, i to 6 or i to 4, especially 1 to 3, carbon atoms, wherein Replacement of alkoxy groups up to 8, 1 to 6 or especially 1 to 4 carbon atoms 'e.g. 2-methoxyethoxy, 2-ethoxyethoxy, 3, methoxypropoxy , 3-ethoxypropoxy and the like. A radical: a group of the formula R-CO-, wherein r is an alkyl group as defined above, for example, 'CVCio alkyl, (:丨-(: 8 burnt base, burnt base, cvc^ base, CrC2 yard base or C3_C: 4 burn base. Examples are ethyl acetyl, propyl thiol and the like. Examples of the CrC4 alkylcarbonyl group are a propylcarbonyl group, an isopropyl group, a n-butylcarbonyl group, a second butylcarbonyl group, an isobutylcarbonyl group and a tert-butylcarbonyl group. a group of the formula R-CO- wherein r is 149027.doc -24-201103430 _alkyl as defined above, for example, Cl-C10 haloalkyl, Ci_c8-alkyl, Ci_c6-alkane a group, C^-C4 haloalkyl, c, -C2 haloalkyl or C3_C4 haloalkyl. Examples are difluoromethyl-rebel, tri-l-methyl-methyl, 2,2-difluoroethyl ketone, 2,2,3•trifluoroethylcarbonyl and the like. Alkoxycarbonyl: a group of the formula R-CO-, wherein R is alkoxy as defined above, for example, Cl_ClQ alkoxy, Ci_C8 alkoxy, Ci_C6 alkoxy, q-C4 alkoxy 4Cl_C2 alkoxy base. Examples of the C "C4 alkoxycarbonyl group are an anthraceneoxycarbonyl group, an ethoxycarbonyl group, a propoxycarbonyl group, an isopropoxycarbonyl group, a n-butoxycarbonyl group, a second butoxycarbonyl group, an isobutoxycarbonyl group and a third butoxycarbonyl group. Oxycarbonyl: a group of the formula R-CO-, wherein the rudent is i alkoxy as defined above 'eg 'Ci-Cw haloalkoxy, Cl_c8 haloalkoxy, Cl_C6_alkoxy, Cl_c4 haloal Oxyl or Ci_c2 haloalkoxy. Examples of Ci_c4 haloalkyloxycarbonyl are difluoromethoxycarbonyl, trifluoromethoxycarbonyl, 2,2-difluoroethoxycarbonyl, 2,2,3-trifluoroethoxycarbonyl And an analogue thereof. Alkylaminocarbonyl: a group of the formula R-NH-CO-, wherein R is an alkyl group as defined above, for example, C丨-C1()alkyl, Ci-Cs alkyl, C - C6 alkyl, C!-C4 leumino, c丨-C2 alkyl or C3-C4 alkyl. C] -C4 alkylaminocarbonyl examples are mercaptoaminocarbonyl, ethylaminocarbonyl, A propylaminocarbonyl group, an isopropylaminocarbonyl group, a butylaminocarbonyl group, a second butylaminocarbonyl group, an isobutylaminocarbonyl group, and a tert-butylaminocarbonyl group. Rr, a group of N-CO-, wherein R and R are independently of each other An alkyl group as defined above, for example, Ci_Ciq alkyl, (^-(^ alkyl, CrCs alkyl, CVC4 alkyl, CrG alkyl or C3-C4 alkyl. Di-(C^C4))-amine Examples of carbonyl groups are dimethylaminocarbonyl, diethyl 149027.doc -25-201103430 aminoguanidino, dipropylamino group, diisopropylamino group and dibutylaminocarbonyl Alkyl group. A group of the formula R-NH2 wherein R is a group as defined above, for example, alkyl, C-C8 alkyl, Ci-C6 alkyl, Ci-C4, Ci-C2 Alkyl or (: 3_(: 4 alkyl). Examples are amino fluorenyl, hydrazine _ and 2-aminoethyl, 1-, 2- and 3-aminopropyl, 1- and 2-amino 1 -methylethyl, br, 2-, 3- and 4-aminobutyl and the like. A group of the formula RS(O)2, wherein r is an alkane as defined above a group, for example, CVCiq alkyl, C丨-C8 alkyl, (: 丨-(:6 alkyl, CV C4 alkyl or C)-C2 alkyl. An example of a C^-C4 alkylsulfonyl group is A It is confirmed that the base of the base, the base of the B, the base of the C, and the base of the C-based base are 'isopropylidene sulfhydryl group, n-butyl sulfhydryl group, the second butyl sulfonyl group, the isobutyl sulfonyl group and the third butyl sulfonyl group. through An alkyl group as defined above which is bonded by a sulfur atom. A halogen group: a dentate group as defined above which is bonded via a sulfur atom. A dilute sulfur group: an alkenyl group as defined above which is bonded via a sulfur atom. a haloalkenyl group as defined above, which is bonded via a sulfur atom. A thiol group: an alkynyl group as defined above which is bonded via a sulfur atom. Alkynylthio group: an alkynyl group as defined above which is bonded via a sulfur atom. Thio group: a cycloalkyl group as defined above attached via a sulfur atom. The aryl group is a carbocyclic aromatic monocyclic or polycyclic ring having 6 to 16 carbon atoms as a ring member. Examples are phenyl, naphthyl, anthracenyl, phenanthryl, anthracenyl and foundry. The aryl group is preferably a phenyl or naphthyl group, and is especially a stupid group. Phenyl-CrC4 alkyl: CrC4 alkyl (as defined above) wherein one hydrogen atom is replaced by a phenyl group such as benzyl, phenethyl and the like. 149027.doc -26- 201103430 Phenyl-Crq alkoxy hydrogen atom via phenyl replacement 0 * C!-C4 alkoxy (as defined above), one of which, such as benzyloxy, phenethyloxy And similar 3_, 4-, 5_, 6_erythro 7 贝 7-shell saturated, partially unsaturated or most unsaturated carbocyclic groups: cyclopropyl, ring-shaped volcano '% pentyl, cyclohexyl, ring Heptyl, cyclopropenyl, cyclobutenyl-E _ ,., w ^ 戍 戍 alkenyl, 5-hexenyl, cycloheptenyl, cyclobutadienyl, cyclopentadienyl, cyclohexyl Di-diyl, cycloheptadienyl or cycloheptatrienyl. Phenyl is also included in the definition in the form, and is also included in the term aryl (not listed here). 6 or 7-membered saturated, partially unsaturated or most unsaturated heterocyclic ring containing 2 or 3 selected from the group consisting of oxygen, nitrogen (in the form of ship) and sulfur (in the form of S, SO or S〇2) An atom or a group containing a hetero atom and, optionally, 1 or 2 groups selected from C(=〇)&c(=s) as ring members: _% or 4-member saturated or partially unsaturated a heterocyclic ring (hereinafter also referred to as a heterocyclic group) containing 1, 2 or 3 from oxygen, nitrogen (in the form of N*NR) and sulfur (in the form of S, SO or S〇2) a hetero atom of the group and, optionally, 1 or 2 groups selected from c(=0) and c(=S) as a ring member. For example, a monocyclic saturated or partially unsaturated heterocyclic carbon ring member In addition, it also contains 1 to 3 nitrogen atoms and / or 1 oxygen or sulfur atom or 1 or 2 oxygen and / or sulfur atoms and optionally 1 or 2 selected from c (= 〇) and C a group of (=S) such as 2-epoxyethyl, 2-thiapropyl, } or 2-aziridine, 1-, 2- or 3-azetidinyl, -5 a 6-membered saturated or partially wood-saturated heterocyclic ring (hereinafter also referred to as a heterocyclic group) containing 1, 2 or 3 derived from oxygen and nitrogen (in the form of N*NR) 149027.doc -27- 201103430 and heteroatoms of the group consisting of sulfur (in the form of s, so or s〇2) and optionally 1 or 2 selected from C(=0) and c(=s) a 2 group as a ring member: for example, a 'monocyclic saturated or partially unsaturated heterocyclic ring, which in addition to a carbocyclic ring member, also contains 1 to 3 nitrogen atoms and/or 1 oxygen or sulfur atom to form one or two oxygen atoms and / or a sulfur atom and optionally 1 or 2 groups selected from C (=0) and C (= S), for example, 2-tetrahydrofuranyl, 3-tetraoxy. °南基, 3-tetrahydro-butan-2-one, 4-tetrahydroc-butan-2-yl, 5-tetrahydrofuran-2-one, 2-tetrahydrofuran-3 a keto group, a 4-tetrahydroindan-3-one group, a 5-tetrahydrofuran-3-one group, a 2-tetrahydrothiophenyl group, a 3-tetrahydrothiophenyl group, a 3-tetrahydrothiophen-2-one group, 4_tetrahydrothiophene network, 5-tetrahydrothiophen-2-one, 2-tetrahydrothiophen-3-one, 4-tetrahydro. Desphen-3-one, 5-tetrahydrothiophen-3-one, 2-pylotyl, 3-11 bis-ridino, 1-pyrrolidin-2-one, 3-pyrrolidine-2 a keto group, a 4-pyrrole α-butan-2-one group, a 5-° ratio. Ding-2-keto group, 1-° ratio ° -3- keto group, 2-0 ratio 51 pyridine-3-one, 4-pyrrolidin-3-one, 5-pyrrolidin-3- Keto, bromidine-2,5-dione, 3-pyrrolidine-2,5-dione, 3-isoacridinyl, 4-isoxazolyl, 5-isoxazole Base, 3-isothiazolidinyl, 4-isoose. sit. Fixed base, 5-isolated sputum base, 3-he squat α-base, 4-. Specific bite, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxaridinyl, 2-thiazole, 4-thiazolidinyl, 5-thiazolidinyl , 2-imidyl pyridine ' 4-imidazole bite base, 1, 2, 4- ° dioxin. Sit-3-yl, 1,2,4-oxalin-5-yl, 1,2,4-thiadiazolidin-3-yl, 1,2,4-thiadiazolidine-5-yl , hydrazine, 2,4-triazolidine-3-yl, 1,3,4-oxadiazolidine-2-yl, 1,3,4-. Plug two.坐定定-2-基,1,3,4-三嗤 bit-2-yl, 2,3-dihydro〇fu shouting-2--2S-149027.doc 201103430 base, 2,3-dinitrogen α Furan-3-yl, 2,4-dihydrogenate, Nan-2-yl, 2,4-dinitrofuran-3-yl, 2,3-dihydrothiophen-2-yl, 2,3-di Hydrothiophen-3-yl, 2.4-.-rat α-cephen-2-yl, 2,4-di-r-α-e-phen-3-yl, 2 - ° ratio 0 σ lin-2 -yl, 2 - Dtb鸣·^木-3 -基,3 - °比洛,2- 2 -, 3 - °, 咐 - 3 -yl, 2-isoxazolin-3-yl, 3-isoxazoline-3 -yl, 4-isoxazolin-3-yl, 2-isoxazolin-4-yl, 3-isoxazolin-4-yl, 4-isoxazolin-4-yl, 2-iso Oxazolin-5-yl, 3-isoxazolin-5-yl, 4-isoxazolin-5-yl, 2-isothiazolin-3-yl, 3-isothiazolin-3-yl, 4-isothiazolin-3-yl, 2-isothiazolin-4-yl, 3-isothiazolin-4-yl, 4-isothiazolin-4-yl, 2-isothiazolin-5-yl, 3-isothiazolin-5-yl, 4-isoindole. Sitting _ 5 -yl, 2,3 - dihydrogen than saliva-1 -yl, 2,3-dihydrogen. 2 -yl, 2,3-dihydropyrazol-3-yl, 2,3-dihydropyrazol-4-yl, 2,3-dihydro. ratio. Take -5-based, 3,4-dihydrogen. ratio. Take the -1 - base, 3,4 - dihydrogen ratio. Take a 3-base, 3.4-dihydrogen ratio. Take 4-yl, 3,4-dihydrogen. ratio. Sit-5-yl, 4,5-dihydro 0 to 0-spin-1-yl, 4,5-dihydrogen ratio. Sitting on the -3- group, 4,5-dihydrogen ratio. Sit-4-yl, 4.5-dihydrogen. ratio. Sitting on a 5-based, 2,3-dihydrogen. Sitting 2-yl, 2,3-dihydrogen. Oxazol-3-yl, 2,3-dihydrooxazol-4-yl, 2,3-dihydrooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4- Dihydrooxazol-3-yl, 3,4-dihydrocarb. Sodium-4-yl, 3,4-dihydro-deso-5-yl, 3,4-dihydro. Sit-2-yl, 3,4-dihydrogen. Sit-3-yl, 3,4-dihydrogen. evil. Take 4-ki, 2 - brigade. Fixed base, 3-Brigade base, bottom σ base, 1,3-two.恶炫!-5-yl, 2 -tetrazine naphthyl, 4-tetrahydronaphthyl, 2-tetrahydro-septyl, 3-hexahydropyridazinyl, 4-hexahydroindenyl, 2-hexahydrogen. Density base, 4-hexahydrogen. Σσ定基,5 - hexahydro thiol 0 base, 2 - british Qin, 1,3,5 - hexahydro 2 - Qin-2-yl and 1,2,4 - hexanitrogen 149027.doc -29 - 201103430 azine-3-yl and the corresponding _ subunit; ΙΓ, Γ: 7Λ saturated or partially unsaturated heterocyclic ring derived from a hetero atom consisting of oxygen, nitrogen and sulfur: for example, having 7 people In addition to the shellfish, it also has a nitrogen-fixing atom and/or an oxygen or sulfur atom or—or two oxygen=sulfur atoms. For example, Nantou 'tetrachloro-nitrogen-based group and six-gas-based group, such as 2,3,4,5-tetrahydro[1H]azepine, _2_ ^ ' '4~ ' -5- ' -6- -4 ' -6-3·, -4-,-5- 2- , -3-, -4- 3- or -4-yl; or -7-yl, 3,4,5,6-tetrahydro [2-indole- 2, _3_ or _7-yl, 2, 3, 4,7-tetrahydro[1H]azepine, -2, -6- or -7-yl, 2,3,6,7-tetrahydro[1H]azepine-5-,-6- or -7-yl, hexahydroazepine-bu, -SK., tetrahydrooxoyl and hexahydrooxoyl, oxorehyl and corresponding-subunit

Aj,4,5-tetrahydro[1H]oxo_2-, -3-, mono--6|7-yl, 2,3,4,7-tetrahydro-oxo_2-,-3- , ·4·, m7•基, 2,3,6,7•tetrahydro-oxo_2-, small, -4-,-5-, _6- or -7-yl, hexahydro-nitrogen _2_, hydrazine or I group; tetra- and hexahydro-(3-diazine-based, tetra- and hexahydro-indole-nitrohavyl, tetra- and hexahydro-1,3-oxazolyl, tetra- and Hexahydro], 4_. Oxazepine, tetra- and hexachloropurine dioxohyl, tetra- and hexahydro-indole_ 5- or 6-carbene containing 2 or 3 heteroatoms from a group consisting of oxygen, nitrogen and sulfur Family (=maximum unsaturated) heterocyclic ring (=heteroaromatic group), for example 'connected via carbon and contains (1) nitrogen atom or (4) gas atom and! a sulphur or oxygen atom as a ring member of a 5-membered heteroaryl group, such as 2 "fussing base, 3" phoranyl, 2" thiophene, 3 thiophene, 2" bicinch, 3 · J49027 .doc -30- 201103430 Pyrrolyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 3-pyridyl Azyl, pyrazolyl, 5-pyrazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-imidazole , 4-imidazolyl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazole-5-yl, anthracene, 2,4-thiadiazole-3-yl, 1 , 2,4-thiadiazol-5-yl, 1,2,4-triazole-3-yl, ^, oxadiazole-2-yl, 1,3,4-thiadiazol-2-yl And a 1,3,4-triazole-2-yl group; a 5-membered heteroaryl group which is bonded via a nitrogen and has 1 to 3 nitrogen atoms as a ring member, such as. Ratio π _ 1 _ base, β ratio sal _ 1 _ base, taste _ 1 _ base, 1 2 3 triazol-1-yl and 1,2,4-triazol-1-yl; contains 1, 2 Or a 6-membered heteroaryl group having 3 nitrogen atoms as a ring member, such as "biter base, 〇 ratio β _3_美, 0 pyridine-4-yl, 3- 哒, 4- 嗓 嗓, 2-pyrimidinyl, 4-spray. Stationary, 5-pyrimidinyl, 2-pyrazinyl, 1,3,5-triazin-2-yl and 1,2,4-triazin-3-yl; linear C2 alkyl: 2 carbons The divalent unbranched chain of atoms, also known as CH2CH2. The direct bond C2 or 〇3 is a divalent unbranched chain having 2 or 3 carbon atoms, that is, CH2CH2 and CH2CH2CH2. Linear CrC5 alkylene: a divalent unbranched chain having from 1 to 5 carbon atoms, i.e., CH2, CH2CH2, CH2CH2CH2, CH2CH2CH2CH2, and CH2CH2CH2CH2CH2. C2-C5 alkylene: a divalent or preferably unbranched chain having 2 to 5 carbon atoms, such as CH2CH2, -CH(CH3)-, CH2CH2CH2, CH(CH3)CH2, CH2CH(CH3), CH2CH2CH2CH2 CH2CH2CH2CH2CH2. 149027.doc •31 · 201103430

CcC5 alkylene group: a divalent branch having 4 to 5 carbon atoms or preferably an unbranched chain 'e.g., ch2ch2ch2ch2 or ch2ch2ch2ch2ch2. The group -SM is more specifically a group _S-M+, wherein M+ is a metal cation equivalent or an ammonium cation as defined above. The metal cation equivalent is more specifically 1/a Ma+, where a is the valence of the metal and is generally i, 2 or 3 Å. Statements on suitable and preferred characteristics of the compounds of the invention, especially with respect to their substituents Ar Het, A, γ, r1, r2, r3, ruler 4, ruler 5, R6, R6a, R7, R8, R9, R丨. , R, 丨, Rl2, Rl3, Rl4, r15, r16, m, Rd, M, Q and indices, and the statements about their use are themselves and in particular in all possible combinations with each other. If Ar is a heterocyclic ring as defined above, it is preferably attached to the group Y via a c atom. In a preferred embodiment of the invention, Ar is a phenyl group which may have 5, preferably 1, 2 or 3 'better' or 2 substituted base 2, or 1 , 2 or 3 A hetero atom having a hetero atom selected from N, oxime and 5 as a member of a ring, wherein the heteroaryl ring may have a ruthenium group, preferably 2 or 3, more preferably a substituent r3. More specifically, it is preferably selected from the group consisting of N, 有, / 2 3 4 or 5, preferably 2 or 3, more preferably 2 or 2 substituents R 2 phenyl or And a hetero atom of 8 and optionally 1 or 2 other nitrogen atoms as a 5 or 6-membered heteroaryl ring of the ring member, wherein the heteroaryl ring may have 1, 2, 3 or 4, preferably (4) a substituent R3. Suitable 5 or 6 member heteroaromatic groups are listed above. m 149027.doc -32- 201103430 The heteroaryl ring 47' recited above is preferably a ° ratio, such as a guanidine-2-yl, pyridyl or pyridin-4-yl group; a pyrimidinyl group such as 2-pyrimidine '' 4-pyridyl or 5-ylidene; fluorenyl 'such as 2-furyl or 3-furyl; thienyl' such as 2-thienyl or 3-thiophenyl; pyrrolyl, such as 丨-pyrrolyl , 2-pyrrolyl or 3·pyrrolyl, especially 2-pyrrolyl or 3-pyrrolyl; pyridyl such as 1-pyrazolyl, 3-pyrazolyl, 4-pyrazolyl or 5-pyrazole Base, especially 3-pyrazolyl, 4-pyrazolyl or 5-pyrazolyl; imidazolyl, such as 丨_米坐基2_咪. Sodium or 4-mercapto group, especially 2-amimidyl or 4-myristyl; oxazolyl, such as 2-oxazolyl, 4-oxazolyl or 5-oxazolyl; isoxazolyl Such as 3-isooxasyl, 4-isoxazolyl or 5-isoxazolyl; D-zezolyl 'such as 2-hydrazino, 4-thiazolyl or 5-thiazolyl; isothiazolyl, such as 3-isothiazolyl, 4-isothiazolyl or 5-isothiazolyl; and triazolyl, such as 1,2,4-diazolyl, indole, 2,4-triazole-3-yl, anthracene, 2 , 4•Triazolyl, 込3,4-triazol-1-yl' oxime, 3,4·triazol-2-yl or 1,3,4-triazol-3-yl, especially 1,2' 4-Triazolyl or triazole-2-yl. The specified position of attachment is understood to be the "position" with respect to the ring heteroatom and has the highest priority. For example, 5, the position of the connection is specified in the ring containing one ring heteroatom relative to the position of the only-organic hetero atom. In the base towel, the position of the connection is specified relative to the two nitrogen ring atoms and the 2_ position. In the microphone, the specified connection position is relative to the two nitrogen ring atoms!··3· position, in the base, Specify the position of the connection relative to the oxygen ring atom: · position and the 3_ position of the nitrogen ring atom, in the hetero-oxo group 'specified connection position relative to the oxygen ring atom i position and the nitrogen ring atom 2-position, in (d) In the base, the position of the connection is specified relative to the 1-position of the sulfur ring atom and the 3_position of the nitrogen ring atom. In the isothiazolyl group, the position of the 149027.doc -33-201103430 is determined relative to the position of the sulfur ring atom and The position of the nitrogen ring atom, etc.

More preferably, Ar may have i, 2, q, /i4, CAn, more aryl thiophene 4- 々8 Z 3, 4 or 5, preferably! , 2 or 3, preferably 1 or 2 substituents R 2 phenyl, 戋 4 von selected from the following 5- or 6-membered heterocyclic ring: pyridyl group, such as η than bite_2_ base, „ ratio Bite _3_ base or. ratio. 1,4-group; phenyl, such as 2- or 3" thiophene; and. A thiol group such as 2 oxazolyl, oxime or 5-carbazolyl. Especially preferred is an acridinyl group such as. The pyridine-3-yl group or the pyridine-anion group, especially the pyridine-2-yl group, wherein the heteroaromatic ring can have! 2, 3 or 4, preferably i, 2 or 3, more preferably M2 substituents R3. In the case where Ar is a 6-membered heteroaryl ring, it preferably has 〇, i, 2 or 3, more preferably 0, 1 or 2 substituents r3, wherein two or more substituents R3 may be the same Or different. In the case where the core is a 5-membered heteroaryl ring, it preferably has 0, 1 or 2 substituents R3 which may make the two substituent bases 3 the same or different. R2 is preferably selected from the group consisting of dentate, OH, SH, N02, CN, CVC4 alkyl, CVC4 haloalkyl, Ci-C4 alkoxy_Cl_C4 alkyl, Cl_coxy, Cl_C4 alkoxy-C "C4 Alkoxy groups and c--C4 haloalkoxy groups, more preferably selected from the group consisting of fluorine, gas, bromine, (VC4 alkyl, (VC4 haloalkyl, Ci-C* alkoxy and ^halohaloxy) even More preferably selected from the group consisting of fluorine, chlorine, bromine, CH3, chf2, CF3, 0CH3, OCHF2 and 0CF3, and especially selected from the group consisting of fluorine, gas, bromine, ch3, cf3, och3 and ocf3. R3 may be connected via C or N, but Preferably, it is bonded to the C atom of Ar. R3 is preferably selected from the group consisting of halogen 'OH, SH, N〇2, CN, CVC4 alkyl,

LSI 149027.doc ·34· 201103430 C!-C4_^ Base, Ci-C4 alkoxy _ C 1 - C 4 炫, C 1 - C 4 alkoxy, C 1 -C4 succinyl - C1-C4 Alkoxy groups and C1-C4 halogen alkoxy groups, more preferably selected from the group consisting of fluorine, gas, bromine, (VC4 alkyl, CVCU haloalkyl, CVC4 alkoxy and cardio-halo alkoxy, even more preferably selected from Fluorine, gas, bromine, CH3, CHF2, CF3, OCH3, OCHF2 and OCF3, and especially selected from the group consisting of fluorine, gas, bromine, CH3, CF3, OCH3 and OCF3. In detail, the Ar system is selected from the following formula Ar.l to Ar. 50, wherein in the formula Ar.l, the combination of the variables R21, R22, R23, R24 and R25 is selected from the definitions given in the column of Table A below.

Ar.2

Ar.3 Αγ.4 Ar.5 Ar.6 Ar.7

ΑΠΟ Ar.11 Ar.12 Ar.13 Ar.14 Ar.15

Ar.8 Ar.9

Ar.16 Ar.17 Ar.18 Ar.19 Ar.20 Ar.21 Ar.22 Ar.23

Ar.32 Ar.33 Ar.34 Ar.35 Ar.36 Ar.37 Ar.38 Ar.39

Ar.40

Ar.41

Ar.42 Ar.43 149027.doc -35- 201103430

Ar.44 Ar.45 Ar.46 Ar.47 Ar.48 Ar.49 Ar.50

Table A No. R21 R22 R23 R24 R25 Al HHHHH A-2 FHHHH A-3 HFHHH A-4 HHFHH A-5 Cl HHHH A-6 H Cl HHH A-7 HH Cl HH A-8 Br HHHH A-9 H Br HHH A-10 HH Br HH A-ll ch3 HHHH A-12 H ch3 HHH Al 3 HH ch3 HH A-14 chf2 HHHH Al 5 H chf2 HHH A-16 HH chf2 HH A-17 cf3 HHHH Al 8 H cf3 HHH A- 19 HH cf3 HH A-20 och3 HHHH A-21 H OCH3 HHH A-22 HH OCH3 HH A-23 OCHF2 HHHH A-24 H OCHF2 HHH A-25 HH OCHF2 HH A-26 OCF3 HHHH A-27 H OCF3 HHH m 149027.doc -36· 201103430

No. R21 R22 R23 R24 R25 A-28 HH OCF3 HH A-29 FFHHH A-30 FHFHH A-31 FHHFH A-32 FHHHF A-33 HFFHH A-34 HFHFH A-35 Cl Cl HHH A-36 Cl H Cl HH A -37 Cl HH Cl H A-38 Cl HHH Cl A-39 H Cl Cl HH A-40 H Cl H Cl H A-41 Br Br HHH A-42 Br H Br HH A-43 Br HH Br H A-44 Br HHH Br A-45 H Br Br HH A-46 H Br H Br H A-47 ch3 ch3 HHH A-48 ch3 H ch3 HH A-49 ch3 HH ch3 H A-50 ch3 HHH ch3 A-51 H ch3 ch3 HH A-52 H ch3 H ch3 H A-53 chf2 chf2 HHH A-54 chf2 H chf2 HH A-55 chf2 HH chf2 H A-56 chf2 HHH chf2 A-57 H chf2 chf2 HH A-58 H chf2 H chf2 H A-59 cf3 cf3 HHH A-60 cf3 H cf3 HH A-61 cf3 HH cf3 H 149027.doc -37- 201103430

No. R21 R22 R23 R24 R25 A-62 cf3 HHH cf3 A-63 H cf3 cf3 HH A-64 H cf3 H cf3 H A-65 OCH3 OCH3 HHH A-66 OCH3 H OCH3 HH A-67 OCH3 HH OCH3 H A-68 OCH3 HHH OCH3 A-69 H OCH3 OCH3 HH A-70 H OCH3 H OCH3 H A-71 OCHF2 OCHF2 HHH A-72 OCHF2 H OCHF2 HH A-73 OCHF2 HH OCHF2 H A-74 OCHF2 HHH OCHF2 A-75 H OCHF2 OCHF2 HH A-76 H ochf2 H OCHF2 H A-77 OCF3 OCF3 HHH A-78 OCF3 H OCF3 HH A-79 OCF3 HH OCF3 H A-80 OCF3 HHH OCF3 A-81 H OCF3 OCF3 HH A-82 H OCF3 H OCF3 H A-83 F Cl HHH A-84 FH Cl HH A-85 FHH Cl H A-86 FHHH Cl A-87 HF Cl HH A-88 HFH Cl H A-89 Cl FHHH A-90 Cl HFHH A-91 Cl HHFH A-92 H Cl FHH A-93 F Br HHH A-94 FH Br HH A-95 FHH Br H

[SI 149027.doc -38- 201103430

No. R21 R22 R23 R24 R25 A-96 FHHH Br A-97 HF Br HH A-98 HFH Br H A-99 Br FHHH A-100 Br HFHH A-101 Br HHFH A-102 H Br FHH A-103 F ch3 HHH A-104 FH ch3 HH A-105 FHH ch3 H A-106 FHHH ch3 A-107 HF ch3 HH A-108 HFH ch3 H A-109 ch3 FHHH A-110 ch3 HFHH A-lll ch3 HHFH A-112 H ch3 FHH A-113 F chf2 HHH A-114 FH chf2 HH A-115 FHH chf2 H A-116 FHHH chf2 A-117 HF chf2 HH A-118 HFH chf2 H A-119 chf2 FHHH A-120 chf2 HFHH A-121 chf2 HHFH A-122 H chf2 FHH A-123 F cf3 HHH A-124 FH cf3 HH A-125 FHH cf3 H A-126 FHHH cf3 A-127 HF cf3 HH A-128 HFH cf3 H A-129 cf3 FHHH 149027.doc • 39- 201103430

No. R21 R22 R23 R24 R25 A-130 cf3 HFHH A-131 cf3 HHFH A-132 H cf3 FHH A-133 F och3 HHH A-134 FH och3 HH A-135 FHH och3 H A-136 FHHH och3 A-137 HF och3 HH A-138 HFH och3 H A-139 och3 FHHH A-140 och3 HFHH A-141 och3 HHFH A-142 H och3 FHH A-143 F ochf2 HHH A-144 FH ochf2 HH A-145 FHH ochf2 H A-146 FHHH Ochf2 A-147 HF ochf2 HH A-148 HFH ochf2 H A-149 ochf2 FHHH A-150 ochf2 HFHH A-151 ochf2 HHFH A-152 H ochf2 FHH A-153 F ocf3 HHH A-154 FH ocf3 HH A-155 FHH Ocf3 H A-156 FHHH ocf3 A-157 HF ocf3 HH A-158 HFH ocf3 H A-159 ocf3 FHHH A-160 ocf3 HFHH A-161 ocf3 HHFH A-162 H ocf3 FHH A-163 Cl Br HHH

[si 149027.doc -40- 201103430

No. R21 R22 R23 R24 R25 A-164 Cl H Br HH A-165 Cl HH Br H A-166 Cl HHH Br A-167 H Cl Br HH A-168 H Cl H Br H A-169 Br Cl HHH A-170 Br H Cl HH A-171 Br HH Cl H A-172 H Br Cl HH A-173 Cl ch3 HHH A-174 Cl H ch3 HH A-175 Cl HH ch3 H A-176 Cl HHH ch3 A-177 H Cl ch3 HH A-178 H Cl H ch3 H A-179 ch3 Cl HHH A-180 ch3 H Cl HH A-181 ch3 HH Cl H A-182 H ch3 Cl HH A-183 Cl chf2 HHH A-184 Cl H chf2 HH A -185 Cl HH chf2 H A-186 Cl HHH chf2 A-187 H Cl chf2 HH A-188 H Cl H chf2 H A-189 chf2 Cl HHH A-190 chf2 H Cl HH A-191 chf2 HH Cl H A-192 H chf2 Cl HH A-193 Cl cf3 HHH A-194 Cl H cf3 HH A-195 Cl HH cf3 H A-196 Cl HHH cf3 A-197 H Cl cf3 HH 149027.doc • 41 · 201103430

No. R21 R22 R23 R24 R25 A-198 H Cl H cf3 H A-199 cf3 Cl HHH A-200 cf3 H Cl HH A-201 cf3 HH Cl H A-202 H cf3 Cl HH A-203 Cl och3 HHH A-204 Cl H och3 HH A-205 Cl HH och3 H A-206 Cl HHH och3 A-207 H Cl och3 HH A-208 H Cl H och3 H A-209 och3 Cl HHH A-210 och3 H Cl HH A-211 och3 HH Cl H A-212 H och3 Cl HH A-213 Cl ochf2 HHH A-214 Cl H ochf2 HH A-215 Cl HH ochf2 H A-216 Cl HHH OCHF2 A-217 H Cl ochf2 HH A-218 H Cl H ochf2 H A-219 ochf2 Cl HHH A-220 ochf2 H Cl HH A-221 ochf2 HH Cl H A-222 H ochf2 Cl HH A-223 Cl ocf3 HHH A-224 Cl H ocf3 HH A-225 Cl HH ocf3 H A-226 Cl HHH OCF3 A-227 H Cl ocf3 HH A-228 H Cl H ocf3 H A-229 ocf3 Cl HHH A-230 ocf3 H Cl HH A-231 ocf3 HH Cl H m: 149027.doc -42- 201103430

No. R21 R22 R23 R24 R25 A-232 H OCF3 Cl HH A-233 Br ch3 HHH A-234 Br H ch3 HH A-235 Br HH ch3 H A-236 Br HHH ch3 A-237 H Br ch3 HH A-238 H Br H ch3 H A-239 ch3 Br HHH A-240 ch3 H Br HH A-241 ch3 HH Br H A-242 H ch3 Br HH A-243 Br chf2 HHH A-244 Br H chf2 HH A-245 Br HH chf2 H A-246 Br HHH chf2 A-247 H Br chf2 HH A-248 H Br H chf2 H A-249 chf2 Br HHH A-250 chf2 H Br HH A-251 chf2 HH Br H A-252 H chf2 Br HH A -253 Br cf3 HHH A-254 Br H cf3 HH A-255 Br HH cf3 H A-256 Br HHH cf3 A-257 H Br cf3 HH A-258 H Br H cf3 H A-259 cf3 Br HHH A-260 cf3 H Br HH A-261 cf3 HH Br H A-262 H cf3 Br HH A-263 Br OCH3 HHH A-264 Br H OCH3 HH A-265 Br HH OCH3 H 149027.doc -43- 201103430

No. R21 R22 R23 R24 R25 A-266 Br HHH OCH3 A-267 H Br OCH3 HH A-268 H Br H OCH3 H A-269 OCH3 Br HHH A-270 OCH3 H Br HH A-271 OCH3 HH Br H A-272 H OCH3 Br HH A-273 Br OCHF2 HHH A-274 Br H OCHFz HH A-275 Br HH OCHF2 H A-276 Br HHH OCHFz A-277 H Br OCHF2 HH A-278 H Br H OCHF2 H A-279 OCHF2 Br HHH A-280 OCHF2 H Br HH A-281 OCHF2 HH Br H A-282 H OCHF2 Br HH A-283 Br OCF3 HHH A-284 Br H OCF3 HH A-285 Br HH OCF3 H A-286 Br HHH OCF3 A- 287 H Br OCF3 HH A-288 H Br H OCF3 H A-289 OCF3 Br HHH A-290 OCF3 H Br HH A-291 OCF3 HH Br H A-292 H OCF3 Br HH A-293 ch3 chf2 HHH A-294 ch3 H chf2 HH A-295 ch3 HH chf2 H A-296 ch3 HHH chf2 A-297 H ch3 chf2 HH A-298 H ch3 H chf2 H A-299 chf2 ch3 HHH m 149027.doc -44- 201103430

No. R21 R22 R23 R24 R25 A-300 chf2 H ch3 HH A-301 chf2 HH ch3 H A-302 H chf2 ch3 HH A-303 ch3 cf3 HHH A-304 ch3 H cf3 HH A-305 ch3 HH cf3 H A-306 Ch3 HHH cf3 A-307 H ch3 cf3 HH A-308 H ch3 H cf3 H A-309 cf3 ch3 HHH A-310 cf3 H ch3 HH A-311 cf3 HH ch3 H A-312 H cf3 ch3 HH A-313 ch3 och3 HHH A-314 ch3 H OCH3 HH A-315 ch3 HH OCH3 H A-316 ch3 HHH OCH3 A-317 H ch3 OCH3 HH A-318 H ch3 H OCH3 H A-319 OCH3 ch3 HHH A-320 OCH3 H ch3 HH A -321 OCH3 HH ch3 H A-322 H 〇CH3 ch3 HH A-323 ch3 OCHF2 HHH A-324 ch3 H OCHF2 HH A-325 ch3 HH OCHF2 H A-326 ch3 HHH OCHF2 A-327 H ch3 OCHF2 HH A-328 H ch3 H OCHF2 H A-329 OCHF2 ch3 HHH A-330 OCHF2 H ch3 HH A-331 OCHF2 HH ch3 H A-332 H OCHF2 ch3 HH A-333 ch3 OCF3 HHH 149027.doc -45- 201103430

No. R21 R22 R23 R24 R25 A-334 ch3 H OCF3 HH A-335 ch3 HH OCF3 H A-336 ch3 HHH OCF3 A-337 H ch3 OCF3 HH A-338 H ch3 H OCF3 H A-339 OCF3 ch3 HHH A-340 OCF3 H ch3 HH A-341 OCF3 HH ch3 H A-342 H OCF3 ch3 HH A-343 chf2 cf3 HHH A-344 chf2 H cf3 HH A-345 chf2 HH cf3 H A-346 chf2 HHH cf3 A-347 H chf2 cf3 HH A-348 H chf2 H cf3 H A-349 cf3 chf2 HHH A-350 cf3 H chf2 HH A-351 cf3 HH chf2 H A-352 H cf3 chf2 HH A-353 chf2 OCH3 HHH A-354 chf2 H OCH3 HH A -355 chf2 HH OCH3 H A-356 chf2 HHH OCH3 A-357 H chf2 OCH3 HH A-358 H chf2 H OCH3 H A-359 OCH3 chf2 HHH A-360 OCH3 H chf2 HH A-361 OCH3 HH chf2 H A-362 H OCH3 chf2 HH A-363 chf2 OCHF2 HHH A-364 chf2 H OCHF2 HH A-365 chf2 HH OCHF2 H A-366 chf2 HHH OCHF2 A-367 H chf2 OCHF2 HH

[s] 149027.doc • 46- 201103430

No. R21 R22 R23 R24 R25 A-368 H chf2 H OCHF2 H A-369 OCHF2 chf2 HHH A-370 OCHF2 H chf2 HH A-371 OCHF2 HH chf2 H A-372 H OCHF2 chf2 HH A-373 chf2 OCF3 HHH A-374 Chf2 H OCF3 HH A-375 chf2 HH OCF3 H A-376 chf2 HHH OCF3 A-377 H chf2 OCF3 HH A-378 H chf2 H OCF3 H A-379 〇CF3 chf2 HHH A-380 OCF3 H chf2 HH A-381 OCF3 HH chf2 H A-382 H OCF3 chf2 HH A-383 cf3 OCH3 HHH A-384 cf3 H OCH3 HH A-385 cf3 HH OCH3 H A-386 cf3 HHH OCH3 A-387 H cf3 OCH3 HH A-388 H cf3 H 〇 CH3 H A-389 OCH3 cf3 HHH A-390 OCH3 H cf3 HH A-391 OCH3 HH cf3 H A-392 H OCH3 cf3 HH A-393 cf3 OCHF2 HHH A-394 cf3 H OCHF2 HH A-395 cf3 HH OCHF2 H A -396 cf3 HHH OCHF2 A-397 H cf3 OCHF2 HH A-398 H cf3 H ochf2 H A-399 OCHF2 cf3 HHH A-400 OCHF2 H cf3 HH A-401 OCHF2 HH cf3 H 149027.doc -47- 201103430

No. R21 R22 r23 R24 R25 A-402 H OCHF2 cf3 HH A-403 cf3 OCF3 HHH A-404 cf3 H OCF3 HH A-405 cf3 HH OCF3 H A-406 cf3 HHH OCF3 A-407 H cf3 OCF3 HH A-408 H Cf3 H OCF3 H A-409 OCF3 cf3 HHH A-410 OCF3 H cf3 HH A-411 OCF3 HH cf3 H A-412 H OCF3 cf3 HH A-413 OCH3 ochf2 HHH A-414 OCH3 H OCHF2 HH A-415 OCH3 HH OCHF2 H A-416 OCH3 HHH OCHF2 A-417 H OCH3 OCHF2 HH A-418 H OCH3 H OCHF2 H A-419 ochf2 OCH3 HHH A-420 OCHF2 H OCH3 HH A-421 OCHF2 HH OCH3 H A-422 H OCHF2 OCH3 HH A -423 OCH3 OCF3 HHH A-424 OCH3 H OCF3 HH A-425 OCH3 HH OCF3 H A-426 OCH3 HHH OCF3 A-427 H OCH3 OCF3 HH A-428 H OCH3 H OCF3 H A-429 OCF3 OCH3 HHH A-430 OCF3 H OCH3 HH A-431 OCF3 HH OCH3 H A-432 H OCF3 OCH3 HH A-433 ochf2 OCF3 HHH A-434 OCHF2 H OCF3 HH A-435 OCHF2 HH OCF3 H

[si 149027.doc -48- 201103430 No. R21 R22 R23 R24 R25 A-436 OCHF2 HHH OCF3 A-437 H OCHF2 OCF3 HH A-438 H OCHF2 H OCF3 H A-439 OCF3 OCHF2 HHH A-440 OCF3 H OCHF2 HH A -441 OCF3 HH OCHF2 H A-442 H OCF3 OCHF2 HH A-443 FFFHH A-444 FFHFH A-445 FFHHF A-446 FHFFH A-447 FHFHF A-448 HFFFH A-449 Cl Cl Cl HH A-450 Cl Cl H Cl H A-451 Cl Cl HH Cl A-452 Cl H Cl Cl H A-453 Cl H Cl H Cl A-454 H ei Cl Cl H A-455 Br Br Br HH A-456 Br Br H Br H A- 457 Br Br HH Br A-458 Br H Br Br H A-459 Br H Br H Br A-460 H Br Br Br H A-461 ch3 ch3 ch3 HH A-462 ch3 ch3 H ch3 H A-463 ch3 ch3 HH Ch3 A-464 ch3 H ch3 ch3 H A-465 ch3 H ch3 H ch3 A-466 H ch3 ch3 ch3 H A-467 cf3 cf3 cf3 HH A-468 cf3 cf3 H cf3 H A-469 cf3 cf3 HH cf3 149027.doc 49- 201103430

No. R21 R22 R23 R24 R25 A-470 cf3 H cf3 cf3 H A-471 cf3 H cf3 H cf3 A-472 H cf3 cf3 cf3 H A-473 FH Cl HF A-474 FHFH Cl A-475 FH Cl FH A-476 FH Cl H Cl A-477 Cl HFH Cl A-478 Cl H Cl FH A-479 Cl H Cl HF A-480 Cl HFFH A-481 Cl FHFH A-482 FHHF Cl A-483 F Cl H Cl H A-484 F Cl HH Cl A-485 HFFH Cl A-486 Cl FHHF A-487 FH Cl Cl H A-488 FH ch3 HF A-489 FHFH ch3 A-490 FH ch3 FH A-491 FH ch3 H ch3 A-492 ch3 HFH Ch3 A-493 ch3 H ch3 FH A-494 ch3 H ch3 HF A-495 ch3 HFFH A-496 ch3 FHFH A-497 FHHF ch3 A-498 F ch3 H ch3 H A-499 F ch3 HH ch3 A-500 HFFH ch3 A-501 ch3 FHHF A-502 FH ch3 ch3 H A-503 FH cf3 HF

L SI 149027.doc -50- 201103430 No. R21 R22 R23 R24 R25 A-504 FHFH cf3 A-505 FH cf3 FH A-506 FH cf3 H cf3 A-507 cf3 HFH cf3 A-508 cf3 H cf3 FH A-509 cf3 H cf3 HF A-510 cf3 HFFH A-511 cf3 FHFH A-512 FH a HF cf3 A-513 F cf3 H cf3 H A-514 F cf3 HH cf3 A-515 HFFH cf3 A-516 cf3 FHHF A-517 FH cf3 Cf3 H A-518 Cl H ch3 H Cl A-519 Cl H Cl H ch3 A-520 Cl H ch3 Cl H A-521 Cl H ch3 H ch3 A-522 ch3 H Cl H ch3 A-523 ch3 H ch3 Cl H A-524 ch3 H ch3 H Cl A-525 ch3 H Cl Cl H A-526 ch3 Cl H Cl H A-527 Cl HH Cl ch3 A-528 Cl ch3 H ch3 H A-529 Cl ch3 HH ch3 A-530 H Cl Cl H ch3 A-531 ch3 Cl HH Cl A-532 Cl H ch3 ch3 H A-533 Cl H cf3 H Cl A-534 Cl H Cl H cf3 A-535 Cl H cf3 Cl H A-536 Cl H cf3 H Cf3 A-537 cf3 H Cl H cf3 149027.doc -51 - 201103430 No. R21 R22 R23 R24 r25 Α-538 cf3 H cf3 Cl H Α-539 cf3 H cf3 H ---—. Cl Α-540 cf3 H Cl Cl ---- H Α-541 cf3 Cl H Cl ---.. H Α-542 Cl HH Cl cf3 ~~~~~~ Α-543 Cl cf3 H cf3 — H Α-544 Cl cf3 HH cf3 Α-545 H Cl Cl H cf3 Α-546 cf3 Cl HH ----- Cl Α-547 Cl H cf3 CF3 — H Α-548 cf3 H Cl H ---- F Α-549 Cl H Cf3 F ---___ H Α-550 cf3 H Cl F —— _ H Α-551 cf3 FH Cl --- — H Α-552 Cl HHF —--- cf3 Α-553 Cl H cf3 F ---- H Α-554 Cl H ch3 FH Α-555 ch3 FH Cl " ----~-- H Α-556 ch3 H Cl F ---- H Α-557 Cl H — HF ch3 Α-558 Cl H ch3 FH '------

Het is preferably attached to the group γ and the fourth carbon atom (having a condensed group of 8 and a tris-l-methyl group) via two ring c-atoms. In a preferred embodiment of the present invention, Het is a (:valent) 5 or 6-membered heteroaryl ring containing i, 2 or 3 hetero atoms selected from N, fluorene and 8 as ring members, 4 The heteroaromatic ring may have 1, 2, 3 or 4, preferably ! or 2 substituents R. More specifically, Het is preferably A winter κ is 3 having one hetero atom selected from N, Ο and S and optionally 丨 or 2 Μ μ # d, and his nitrogen atom as a ring member 5- or 6-beyzepine wherein the heteroaryl ring is substituted for R4 μ + , with 1, 2, 3 or 4, preferably 1 or 2 substituents R. The 疋5- or 6-bey heteroaromatic groups are listed above. 149027.doc • 52· 201103430 In the heteroaryl ring enumerated above, it is preferred to extend a π-pyridyl group such as a 2,3-extended pyridyl group and a 2,4-extension. Bipyridyl, 2,5-extended pyridyl, 2,6-extension. Pyridyl, 3.4-extended pyridyl or 3,5-extended pyridyl; pyrimidinyl, such as 2,4-exipyridyl, 2,5-exipyrimidinyl, 4,5-exipyrimidinyl or 4,6 _ stretching pyrimidinyl; stretching furanyl 'such as 2,3 · 嗔 嗔 base, 2, 4 _ „ 夫 味, 2,5 _ 吱 吱 or 3.4- stretching furyl; thienyl, such as 2, 3_Thienyl, 2, thiophene, 2,5-thienyl or 3,4-extended phenyl; π-pyrylene, such as hydrazine, 2, pyrrolyl, 1,3-extension a thiol group, a 2,3-extended fluorenyl group, a 2,4-extended fluorenyl group, a 2,5-extended pyrrolyl group or a 3,4-extended pyrrolyl group; a pyrazolyl group such as a pyrazolyl group, 1, 4 - an extended carbazolyl group, a ten-saltyl group, a 3,4-extension, a oxazolyl group or a 3,5-exi-pyrazolyl group; an extended imidazolyl group such as i, an extended imidazolyl group, an M-extended imidazolyl group, 1' 5· stretching base, 2'4-extension D sitting base, 2,5_ stretching base or 4,5_extension imidazolyl H sitting group, such as 2,4-thiazole or 2,5• An oxazolyl group; an isoxazolyl group such as an M-exoisoxazole group or a 3,5-exoisoxazolyl group; a thiophene group; a group such as a 2,4-thiazole or a 2,5-thiazolyl group; Extending a thiazolyl group, such as a 3,4-extended (tetra) group or a 3,5-extension sigh; Sitting base, such as 1 2 - stretching, recording, or stretching, and specifying the position of the connection is understood to be the highest priority with respect to the ring heteroatom d• position. For example, in the case of In the ring of the ring hetero atom, the specified connection position is in the 坐· position m of the mono-ring hetero atom, and the specified connection position is relative to the two nitrogen ring atoms and the 2_ position, in the extension center 'Specified connection position relative to the position of the two nitrogen ring atoms and the position of the ^, in the exudation of the saliva group, the position of the connection position relative to the position of the oxygen ring atom and the position of the nitrogen ring atom 3-position, in the extension of the oxazolyl group Wherein, the specified position is relative to the position of the oxygen ring atom and the position of the nitrogen ring atom in the position of H9027.doc 53·201103430, in the thiazolyl group, the position of the crypto connection relative to the position of the sulfur ring atom and the nitrogen ring atom The position is in the extension. Sitting on the I towel, specifying the position of the connection relative to the position of the sulfur ring atom and the 2-position of the nitrogen ring atom, etc. More preferably, the pyridyl group, especially 2, 5 or 3' 6_Extension: a pyridyl group; a thienyl group, especially a 2,4- or 2,5-thenylene group; An oxazolyl group, especially a thiazole group or a 2,5-thiazole group. Even more preferably, it is a pyridine group, especially a 2,5• or 3,6-extended azide group; and a thienyl group, especially 2, 4_ or 2,5_Thienthylene, especially preferably an exifluoridyl group, especially a 2,5- or 3,6-exetidinyl group. In the case where Het is a 6-membered heteroaryl ring, Preferably, it has fluorene, fluorene, 2 or 3, more preferably 0, 1 or 2 substituents R4, wherein two or more substituents R4 may be the same or different. In the case where Het is a 5-membered heteroaryl ring It preferably has 0, 1 or 2 substituents R4, wherein the two substituent bases 4 may be the same or different. R4 may be attached via C- or Ν-, but is preferably attached to the c atom of Het. R4 is preferably selected from the group consisting of halogen, OH, SH'N02, CN, Ci_c4 alkyl, G-C4 halogen alkyl, Ci-C* methoxy-CVC4 alkyl, Ci-Czj alkoxy, c] C4 oxygenated -CVC4 alkoxy and C]-C: 4 halo alkoxy, more preferably selected from the group consisting of gas, gas, bromine, C-C4 alkyl, C丨-C4 haloalkyl, C丨-c4 alkoxy And 〇丨_(34 haloalkoxy) is even more preferably selected from the group consisting of fluorine, gas, bromine, CH3, CHF2, CF3, OCH3, OCHFA OCF3, especially preferably selected from the group consisting of fluorine, gas, and CH3, cf3 'och3 and OCF3 And especially selected from the group consisting of fluorine and gas. In particular, Het is selected from the group consisting of Het.l to Het.16, wherein # is the linkage to the fourth carbon atom (which has a ketal and a triazolylmethyl group). Point and * is the connection

t SI 149027.doc -54- 201103430 Connection point to base 圑:

Xr#

Het.2

Cl

# F Het.3

#

Het.1 Het.4

Het.11 Het.12 Het.13

Het.14

Het. 15 Het. 16 Among the above formulas, preferred groups are Het丨 to Het丨〇. The group 8 in the group -c(=〇)m _S(0)2R8 is preferably selected from the group consisting of Ci_C4 alkyl, CVCd alkyl, (^-(^ alkoxy, Ci_Cd alkoxy, stupyl, phenoxy) And NRl3Rl4, more preferably selected from the group consisting of CA alkyl, CrC2 dentate, Cl_C4 alkoxy, CVCd methoxy & NRnR14 and even more preferably selected from the group consisting of CA alkyl, CVC4 alkoxy & NRnRu. In the case of r8, r8 is especially a fluorene group, such as methyl, ethyl, propyl, isopropyl, n-butyl, t-butyl, isobutyl or t-butyl' is preferably Indenyl, or a G-C4 alkoxy group such as methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, second butoxy, isobutoxy or tert-butoxy a group, preferably a methoxy group, and more particularly a methyl group, and in the group _s(〇)2R8, γ is especially a methyl group. Preferably, R13 is hydrogen and RI4 is selected from hydrogen, alkyl. And phenyl, preferably selected from hydrogen and Ci_C4 alkyl; or both 丨3 and 丨4 are C] _C4 149027.doc -55- 201103430 alkyl, preferably methyl or ethyl. From an alkali metal cation, an alkaline earth metal cation equivalent, a cation equivalent of Cu, Zn, Fe or Ni or a formula (N An ammonium cation of RaRbReRd), wherein one of Ra, Rb, ^ and ... is hydrogen and three of Ra, Rb, ^ and Rd are independently selected from each other from Ci_C|g alkyl. More preferably, % is Equivalent from L丨+, Na+, K+, 〖/2Mg2+, Cu, Ζη, 卜 or shame, and an ammonium cation of the formula (NRaRbRCRY, one of ten Ra, Rb, rc and Rd is hydrogen and V Three of R, ^ and ... are independently selected from qc. Burning groups. Even more preferably, M is selected from the group consisting of Na+, κ+, 1/2 core 2+, "Cu2, i/2Zn2+, 1 2+, _2+, triethylammonium and trimethylammonium. In the group of the formula, the variable preferably has the same meaning as in the rest of the molecule j. Because &, the above meanings about the group The same applies to this part. R is preferably selected from the group consisting of hydrogen, 〇^-(:4 alkyl, _C(= 〇)R8, s(〇)2r8, -CN, Μ and the group of formula m. R8 has one of the above general meanings, or particularly one of the above preferred meanings, and M has one of the above general meanings, or particularly one of the above preferred meanings. R is more preferably selected from the group consisting of hydrogen and c. 〖-C4 alkyl, cvc: 4 alkyl carbonyl, C] _C4 Oxycarbonyl, -CPCONCI^CVC^alkyl, -C(=0)n(Ci_C4 alkyl)2, Ci_C4 alkylsulfonyl, CN, M and a group of formula m, wherein M has the above general meaning One of, or especially one of the above preferred meanings. In detail, 'R is selected from the group consisting of hydrogen, mercapto, ethyl, propyl, isopropyl, methyl methoxy red, _C (= 0) N(CH3)2, CN, μ and a group of the formula III, wherein hydrazine has one of the above general meanings ′ or particularly one of the above preferred meanings [149027.doc-56·201103430 and preferably For the purpose of examining metal cations or % Cu2+®, r1 is hydrogen, methyl, decylcarbonyl, oxime carbonyl, Na+ or a group of formula III. «^ is preferably selected from the group consisting of hydrogen, CVCm alkyl, CVC4 haloalkyl, phenyl, phenyl-C丨-C4 alkyl, -C(=〇)R8 and -S(0)2R8, wherein R8 has the above general One of the meanings' or one of the above preferred meanings. More preferably, Rla is selected from the group consisting of hydrogen, CVC4 alkyl, C, -C4 haloalkyl, phenyl, benzyl, -C(=0)R8 and -S(0)2R8, wherein R8 has the above general meaning One, or especially one of the above preferred meanings, and more preferably selected from the group consisting of hydrogen, Ci-C4 alkyl, CVC4_alkyl, -C(=〇)R8 and _s(〇)2r8, wherein Rs One of the above general meanings, or especially one of the above preferred meanings, is that '11 is hydrogen, C!-C4 alkyl' is preferably methyl or -C(=〇)R8, more particularly It is hydrogen, Ci_C4 alkyl, preferably methyl, methylcarbonyl or methoxycarbonyl, even more particularly hydrogen or Ci_C4 alkyl, preferably fluorenyl and especially hydrogen. γ is preferably 〇. A is preferably a linear C:2 or C3 alkylene bridge wherein the alkylene or one of the hydrogen atoms may be replaced by one or two substituents R5, wherein each Han 5 is independently selected from c]- C4 alkyl, Cl_C4_Hyun, Ci_coxy, alkoxy C4 alkoxy and (^-<:4 haloalkoxy, and preferably selected from decyl, ethyl, methoxyethoxy And a methoxymethoxy group, or two substituents R5 attached to an adjacent carbon atom, together with the carbon atom to which they are attached, form a cyclopentyl or cyclohexyl ring. More preferably, A is a linear Q. Or a C3 alkylene bridge in which one hydrogen atom of the alkylene bridge can be replaced by a substituent, a crucible, a τ fishing ground soil. More preferably, the 'A is a linear 〇2 extension base bridge , wherein the nitrogen atom can be replaced by one substituent r5, wherein R5 is 〇^(:4 alkyl and preferably methyl. In detail, 'A is -CH(CH3)-CH2-. If m is 1, the oxygen atom is preferably bonded to the sulfur atom via a double bond, whereby the group -s(o)m_Rl forms a group "s(=〇)_Rl. If the claw is 2 Preferably, both oxygen atoms are attached to the sulfur atom via a double bond, whereby the group s(Q)m_ Ri forms a group _S(=〇)2_Rl. If 4 3, the group -s(o)m_Rl is a group -S(=0)2-0-R' 〇m is preferably 〇 or 2 and more In the example of the compound, in the compound order, (7) is 〇 and ^ is Η (or otherwise 'in compound II' Η). The specific compound Ι / ΙΙ is as follows: Preferred compounds I and II Examples of helmets, τ , ^ The examples are compounds of the formulae L1 to 1.192 and II.1 to π.96, wherein the variables have one of the above, or the general meaning of the mouth, or particularly preferred meaning. Examples of compounds are summarized in Tables 1 to 70992 below.

Edited individual compounds. Furthermore, the meaning of I s for individual variables in the table itself (not dependent on the combination of the k and the number of k-numbers) is a preferred embodiment of the relevant substituents.

J49027.doc [S3: -58- 201103430

149027.doc -59 201103430

S-s

R23 R22

(1.53)

R23 Ri2

OMe

[SI 149027.doc -60 201103430

149027.doc -61 · 201103430

R21

(1.70)

149027.doc -62- 201103430

149027.doc -63- 201103430

(1.92)

m 149027.doc •64- 201103430

149027.doc -65- 201103430

[s] 149027.doc -66- 201103430

149027.doc -67- 201103430

MeO

OMe

[:s ] 149027.doc • 68 - 201103430

149027.doc -69- 201103430

[s] 149027.doc -70- 201103430

c 201103430

[s] 149027.doc 72- 201103430

149027.doc 73- 201103430

Table 1 Combination of the compounds of formula I · 1 in each case and R1 is η. Table 2 wherein R21 and R22 of the compound correspond to one of the above-mentioned tables, R23, R24 and R25, and Het is a formula of Het. The compound of ii wherein the combination of r2i and r22 of the compound corresponds in each case to the group listed in the above Table A and R1 is a fluorenyl group, 3, R23, R24 and R25, and Het is a compound of the formula Het.1. Wherein the compounds r21, r22, r23, r24 and r25H correspond in each case to the column of the above Table A, Het is a group of the formula Het. 1 and R1 is an ethyl group 4 149027.doc

t SI -74- 201103430 , R23, R24 and R25 , Het is a compound of the formula Het. 1 , formula i. 1 , wherein the combination of the compounds r21 and r2 is in each case in one of the above Table A a group and R1 is a propyl group 5 wherein a compound of R2 1 , R corresponds to a combination of the above-mentioned one of the compounds of the formula propyl group 1 in each case, and the group is a hetero-table 6 22, R 23 , R24 and R25, Het is a group of the formula Het. 1 compound of formula I · 1 in each case and R1 is a positive table 7 'where the compound R21, r22 corresponds to one of the above table A, butyl, R23 ' R24 and R25 , Het are a compound of the formula Het. 1 formula 1.1, wherein the combination is in each case the corresponding group and is the second butyl group 8 compound of R21, R22, R23, R24 & R25 in the above table In one of the columns A, Het is a compound of the formula H1. Formula L1, wherein the combination of R2 and R22 of the compound corresponds in each case to the group listed in the above Table A and R1 is isobutyl. Tables 9, R23, R24 And R25, Het is a compound of the formula Het.1, wherein the compound is r21, r22, r23, r24 and r25. and σ is in each case Corresponding to one of the above Tables a, is a group of the formula ^ and R1 is a compound of the third butyl group 10 149027.doc -75 · 201103430 Formula L1, wherein the combination of the compound of the ruler 21, R22, R23, 1124 and 1125 In each case corresponding to one of the above Table A, Het is a group of the formula Het.l and R1 is a compound of the formula L1 of the phenyl group, wherein the combination of the ruler 21, R22, r23, ruler 24 and r25 of the compound is In each case, corresponding to one of the above Tables 8, Het is a group of the formula Het l and R1 is a compound of the formula benzyl 12, wherein the combination of the compounds R21, R22, R23, R24 & R25 corresponds in each case. In one of the above Tables 8, Het is a group of the formula Het" and R1 is a compound of the formula I.1, wherein the combination of the compounds r21, r22, r23, r24 and r25 corresponds in each case to the above In one of Table 8, Het is a group of the formula Het" and Ri is Na + a compound of the formula 1.1 in Table 14, wherein the combination of the compounds r21, r22, r23, r24 and r25 corresponds in each case to one of the above Table A, Het is a group of the formula Hetl and R1 is K+. Table 15 is a compound of the formula L1 wherein the compound is r2i, r22, r23 r24 and r25 of σ groups in each case one table corresponding to the eight, Het is a group of the formula ^ and feet] of i / 2Mg2 + Table 16

[SI 149027.doc • 76· 201103430 A compound of the formula ι·ι, wherein the combination of the compounds of the formula 2丨, R22, in each case corresponds to the group listed in the above Table A and is considered to be l/2Cu2 + Table 17 - A compound of the formula L1, wherein the combination of the compounds R21, R22, . . . corresponds in each case to the group listed in the above Table A and is considered to be ι/2Ζη2 + Table 18 Formula 1,1, wherein the compound R21, R22 And a combination of R21 in the present case corresponding to the group of the above Table A and R1 is i/2Fe2+ wherein the combination of R21, R22, in each case corresponds to one of the above Table A And R1 is a compound of formula L1, wherein the combination of R21, R22 of the compound corresponds in each case to the group of one of the above Table A and R is NH(CH3)3 + - TABLE 21 A compound of the formula L1 wherein the combination of R2I, R22 of the compound corresponds in each case to the group of the above Table A: R1 is nh(c2h5)3+ Table 22 149027.doc 'R23, R24 and R25, Het is of the formula Het. 1 R23, R24 and R25, Het is of the formula Het. 1 R23, R24 and R25, Het is the formula Het.1 R2 3, R24 and R25, Het is a formula Het.1 R23, R24 and R25, Het is a formula Het.1 R23, R24 and R25 Het is a compound of the formula Het.1 77· 201103430 Formula I. 1, wherein the compound R2! The combination of R22, in each case corresponds to a group of the above Table A, and R1 is NH(CH2CH2CH2)3+ Table 23 Compound of formula 1.1 wherein the combination of compounds R2丨, R22, in each case Corresponding to the group listed in the above Table A and R1 is NH(CH(CH3)2)3+, the compound of the formula 1.1, wherein the combination of the ruler 2丨, R22 of the compound corresponds in each case to the above Table A One of the groups and R1 is ΝΗ((:Η2(:Η2(:Η2(:ϋ2)3 + Table 25 Formula Ι·1 of the compound' wherein the combination of the compound R2!, R22, in each case corresponds to a group of the above Table A and R1 is a methylcarbonyl group of the compound of the formula 1.1, wherein the combination of the compounds of the formula 2, R22, in each case corresponds to the group listed in the above Table A and R1 is B. The compound of the formula 1.1 wherein the combination of the ruthenium 2, R22 of the compound corresponds in each case to the group of one of the above Table A and R1 is propylcarbonyl. Table 28 149027.doc R23, R24 and R25 Het are of the formula Het. 1 R23, R24 and R25, Het is of the formula Het.1 R23, R24 and R25 * Het is a formula Het. 1 R23, R24 and R25 Het is of the formula Het.1 R23, R24 and R25, Het is the formula Het.1 R23, R24 and R25, and Het is the formula Het.1 [S] •78· The combination of the compounds of formula i.1 is based on each case. And R1 is a different form 29 201103430, wherein the compound of R21 and r22 corresponds to a compound of the above formula A, which is a compound of the formula propyl group 1.1, and the combination of the ten compounds of the compound 21 and r22 corresponds in each case to the above table A. a group of the formula and R1 is a methoxycarbonyl group of the compound of the formula L1, wherein the combination of the compounds r2i, R22 corresponds in each case to the group listed in the above Table A and R1 is an ethoxycarbonyl group 31 The compound of 1.1, wherein the combination of the ruler 2, R22 of the compound corresponds in each case to the group listed in the above Table A and R1 is a compound of the formula 1.1 of the propoxycarbonyl group, wherein the compound has a size of 21, R22, The combination in each case corresponds to the group listed in the above Table A and R1 is a combination of isopropoxycarbonyl table 33 Ι·1 The combination of R21 and R22 of the towel compound corresponds in each case to the group listed in the above Table A and R1 is a phenoxycarbonyl group 34. R23, R24 and R25, and Het is a formula Het.l 'R23, R24 and R25, Het is Het.l R23, R24 and R25, Het is Het.l R23, R24 and R25, Het is Het. 1 R23, R24 and R25, Het is Het. 1 R23, R24 and R25, Het is a compound of the formula Het.l 149027.doc •79·201103430, wherein the compound is a combination of r21, r22, r23, r24 and r25, and 0 corresponds in each case to one of the above Table A, Het is a group of the formula Het.l and R1 is a methylaminocarbonyl group. The compound of the formula L1 wherein the combination of R21, R22, R23, R24 and R25 of the compound corresponds in each case to the column of the above Table A, Het Is a group of the formula Het.l and the oxime is an ethylaminocarbonyl group of the compound of the formula L1, wherein the combination of the compounds R21, R22, R23, R24 and R25 corresponds in each case to the above Table A - Column, Het is a group of the formula Het.l and R1 is a propylaminocarbonyl group of the compound of the formula L1, wherein the combination of the compound of R21, R22, R23, R24 and R25 is in each case. In the case of one of the above Table A, Het is a group of the formula Het.1 and R1 is an isopropylaminocarbonyl group. The compound of the formula M wherein the compound of the combination of R21, R22, R23, R24 and R25 is In each case, corresponding to one of the above Table A, Het is a group of the formula Het.1 and R1 is a phenylaminocarbonyl group. The compound of the formula L1 wherein the compound is a group of R21, R22, R23, R24 and R25. In each case corresponding to one of the above Table A, Het is a group of the formula Het.l and R is a sulfonyl sulfhydryl group 40

E SI 149027.doc • 80· 201103430 A compound of the formula L1, wherein the combination of the compounds R21, R22, in each case corresponds to the group listed in the above Table A and R1 is a compound of the formula E1. Wherein the combination of R21 and R22 of the compound corresponds in each case to the group listed in the above Table A and R1 is a compound of the formula 1.4 in the formula 1.4, wherein the combination of the compound R2, r22, In the case of a group corresponding to one of the above Table A and R1 is a compound of the formula L1, wherein the combination of R21, R22 of the compound corresponds in each case to the group of one of the above Tables a. And R1 is a compound of the formula 1-1, wherein the combination of the compounds rZ1, R22, in each case corresponds to a group of the above Table A and R1 is a methoxysulfonyl group. The compound 'wherein the combination of the compounds rS1, R22, in each case corresponds to the group listed in the above Table A and R1 is ethoxysulfonyl group 46 149027.doc R23, R24 and R25, and Het is a formula Het. 1 R23, R24 and R25, Het is the formula Het.1 R23, R24 and R25, Het is Het. 1 R23, R24 and R25, Het is a formula Het. 1 R23, R24 and R25, Het is a formula Het. 1 R23, R24 and R25 ^ Het is a formula Het. 1 •81 - 201103430 A compound of the formula L1, wherein the compound The combination of R21, in each case corresponds to the group of the above Table 8 and R1 is a compound of the formula L1 of the propoxysulfonyl group, wherein the combination of the compound R21, in each case corresponds to the above Table A a group of - and R1 is isopropoxysulfonyl. The compound of formula 1.1 wherein the combination of R2, in each case corresponds to the group of Table A above and R is phenoxy yellow. The compound of the formula 49 wherein R21 of the compound, in each case corresponds to the group of the above Table A, and R1 is a compound of the formula 50 to 98, wherein the compound of the compound 21 is in the combination of In each case corresponds to a column of Table A, a compound of the formulae 99 to 147 as defined in any of the formulas and Het is a group of the formula Het. 2, wherein the combination of the compounds R2, in each case corresponds to Table A One of the columns, defined in either of them, and Het is a group of the formula Het. 3, Tables 148 to 196 149027.doc R22, R23 , R24 and R25 - columns, Het is a formula Het. 1 R22, R23, R24 and R25 - columns, Het is a formula Het. 1 R22, R23, R24 and R25 - columns, Het is a formula Het. 1 R22, R23, R24 And R25-column, Het is of the formula Het. 1 R22, R23, R24 and R25 R1 are as shown in Tables 1 to 49, r22, R23, R24 and R25 Rl are as shown in Tables 1 to 49 [.S] -82- 201103430 A compound of formula 1.1 wherein the combination of R21, R22, R23, R24 and r25 of the compound corresponds in each case to one of the columns of Table A, and R1 is as defined in any of Tables 1 to 49 and Het is a formula Groups of Het. 4 Tables 197 to 245 Compounds of the formula ,·1, wherein the combination of the compounds R21, R22, R23, Han 24 and Ruler 25 corresponds in each case to one of the columns, and R1 is as shown in Table 1. A compound of the formula I wherein the Het is a group of the formula Het. 5, wherein the combination of R21, R22, R23, R24 and R25 of the compound corresponds in each case to In a column of Table A, R1 is as defined in any one of Tables 1 to 49 and Het is a group of the formula Het. 6 in the compounds of the formulae 295 to 343, wherein the compound R21, R22, R23 'han and ^ ^ The combination is in each case In the column of Table A, R1 is as defined in any one of Tables 1 to 49 and Het is a compound of the formulae 344 to 392 of the formula Het. 7 wherein R21, R22, r23, The combination of r24 and r25 corresponds in each case to one of the columns of Table a, R1 is as defined in any of Tables 1 to 49 and Het is a compound of the formulae 393 to 441 of the formula Het. Wherein the combination of R21, R22, r23, trans 24 and ruler 25 of the compound corresponds in each case to one of the columns of Table A, R1 is as defined in any of Tables i to 49 and Het is of the formula Het. Groups 442 to 490 149027.doc -83 - 201103430 Compounds of formula 1.1, wherein the combination of compounds, R22, κ, R24 and R25 corresponds in each case to one of Table A, and R1 is as in Tables 1 to 49. A compound of the formula L1, R22, R23, r24 and r25, as defined in any of the formulas, wherein Het is a group of the formula Het. 10, wherein the combination of R21, R22, R23, r24 and r25 of the compound corresponds in each case to one of the columns of Table A. R1 is a compound as defined in any one of Tables to 49 and Het is a group of formulas 540 to 588 of formula Het. 11 wherein the compound is 21, R22, r23 r24 and r25 of the composition in each case corresponds to one row in Table A, lines as shown in Table! a compound of the formula 589 to 637 of the formula Het. 12, wherein the combination of r21, r22, r23, ruler 24 and ruler 25 of the compound is in each case Corresponding to one of the columns of Table A, R1 is as defined in any one of Tables 1 to 49 and Het is a group of the formula Het. 13 in Tables 638 to 686. The compound of the formula I.1, wherein the compound is r21, r22, The combination of r23, r24 and ruler 25 corresponds in each case to one of the columns of Table A, r1 is as defined in any of Tables 1 to 49 and Het is a group of the formula Het. 14 Tables 687 to 735 Formula L1 The compound 'wherein the combination of R21, r22, R23, r24 and only 25 of the compound corresponds in each case to one of the columns of Table A, R1 is as defined in any of Tables 1 to 49 and Het is of the formula Het. The group of formula L1, wherein the combination of R21, R22, R23, r24 and r25 of the compound corresponds in each case to one of the tables A, and Ri is as in the case of Table 736 to 784 149027.doc -84 - 201103430 Groups 785 to 1568 of the formula Het_16, which are defined in any one of the above-mentioned, and wherein Het is a compound of the formula Het_16, wherein the compound is R2!, r22, r23, ruler 24 and ruler 25 A combination of R1 and Het in each case, and a compound of formula 1.31 to 2352, as defined in any of Tables 1 to 784, wherein the compound, r22, r23, rule 24 And the combination of the ruler 25 corresponds in each case to one of the columns of Table A and the combination of R1 and H et is a compound of the formula 1.43 to 3136 of the formula 1.4 as defined in any one of Tables 1 to 784, wherein the compound r2i, The combination of r22, r23, r24 and r25 corresponds in each case to one of the columns of Table A and the combination of R1 and Het is a compound of the formula 1.51 to 3920, as defined in any of Tables 1 to 784, wherein the compound The combination of r21, r22, r23, ruler 24 and ruler 25 corresponds in each case to one of the columns of Table a and the combination of R1 and Het is as defined in any of Tables 1 to 784, Tables 3921 to 4704, Equation 1.6 a compound wherein the combination of the compounds r2i, R22, r23, r24 and r25 corresponds in each case to one of the columns of Table A and the combination of ri and Het is as defined in Tables 4705 as defined in any of Tables 1 to 784. 5488 149027.doc -85- 201103430 Compound of formula L7, wherein the group of compounds R2, R22, R23, R24 and r25 The combination corresponding to the column of Table A and Rl|%Het in each case is a compound of the formula L5, as defined in any one of Tables 1 to 784, wherein R21, R22, RU, The combination of R24 and r25 corresponds in each case to the column of the column and the combination of Rl^et is as shown in any of Tables 1 to 784, as defined in any of Tables 6273 to 7056, the compound of formula 1.9, wherein the compound is r21, r22 And r23, r24, and combinations thereof, in each case corresponding to one of the listed persons, and the combination is as shown in any one of Tables 1 to 784, and the compounds of the formulas 1.705 to 7840, formula 1.10, wherein the compound is 2, The combination of r22, r23, r24 and R25 corresponds in each case to one of the columns of Table A and the combination of Ri and Het is a compound of the formula 7841 to 8624 as defined in any of Tables 1 to 784. Wherein the combination of the compounds 2, R22, r23, r24 and R25 corresponds in each case to one of the columns of Table A and the combination of Ri and Het is as defined in any of Tables 1 to 784, tables 8625 to 9408. A compound of the formula 1.12, wherein the combination of the compounds r21, r22, r23, r24 and R25 corresponds in each case to Table VIII And a combination of lines as defined in Table 9409 to 10192 149027.doc in Tables 1 to 784 of any one of

[SI-86·201103430 The compound of the formula 1.13 wherein the combination of the compound r2i 'r22 'r23, r24 and R25 corresponds in each case to one of the tables A and the combination of the ruler 1 and Het is as shown in Tables 1 to 784. Any of the compounds of formula I.14 to 10976, formula I.14, wherein the combination of the compounds r21, r22, Han23, r24 and R5 corresponds in each case to one of the columns of Table A and is in combination with R. A compound of the formulae 1.15 to 11760, as defined in any one of Tables 1 to 784, wherein the combination of the ruthenium 2, R22, r23, r24 and R of the compound corresponds in each case to one of the columns of Table A and Ri The combination with Het is as defined in any of Tables 1 to 784, and the combination of 艮21, r22, r23, r24 and R of the compound corresponds in each case to Table A. A combination of R1 and Het is as defined in any of Tables 1 to 784. Tables 12545 to 13328, a compound of formula 1.17, wherein a combination of compounds r2丨, r22, r23, r24 and R 5 is used in each case. The lower one corresponds to one of the columns of the table a and is combined with only the table defined as in any of the tables 1 to 784. 3329 to 141 12 a compound of the formula 1.18, wherein the combination of the ruler 21, r22, r23, ruler 24 and R of the compound corresponds in each case to one of the columns of Table A and the combination of R and Het is as shown in Tables 1 to 7. Table 14113 to 14896 149027.doc • 87· 201103430 A compound of the formula 1.19 in which the combination of 1^21, 1122, 1123, 24 and R25 of the compound corresponds in each case to Table A. And a combination of only R6' R22, R23, R24 and R25 of the compound as defined in any one of Tables 1 to 784. In each case, it corresponds to a column of Table 8 and the combination of R1 and Het is a compound of the formulae 1.261 to 16464 of formula 1.21 as defined in any one of Tables 1 to 784, wherein the compound is r21, r22, r23, and ruler. The combination of 24 and R corresponds in each case to one of the columns of Table A and R1 is combined with a compound of the formulae formulae 16465 to 17248, formula 1.22 as defined in any one of Tables 1 to 784, wherein the compound is 21 The combination of r22, r23, r24 and R corresponds in each case to one of the columns of Table A and R1 is combined with it as shown in Table 1 to A compound of the formula: formula 1249 to 18032, formula 1.23, wherein the combination of the compounds r21, r22, r23, r24 and R25 corresponds in each case to one of the columns of Table A and the combination of Ri and Het A compound of the formula: formula 1.823 to 18816, formula 1.24, as defined in any one of Tables 1 to 784, wherein the combination of the ruler 21, r22, r23, r24 and R25 of the compound corresponds in each case to one of the The combination of R1 and Het is as defined in any one of Tables 1 to 784, and the compounds of the formula 188 17 88 88 88 88 88 25 25 25 25 , , 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 The combination in each case corresponds to one of the columns of Table A and the combination of R1 and Het is a compound of the formula 1601 to 20384, formula 1.26 as defined in any of Tables 1 to 784, wherein the compound is 2, r22, The combination of r23, r24 and 2 5 R corresponds in each case to one of the columns and the combination of R and Het is a compound of the formula: formula 1 485 to 21168, formula 1.27, as defined in any of Tables 1 to 784, wherein The combination of the ruler 21, R22, r23, r24 and R of the compound corresponds in each case to one of the columns of Table A and R1 The combination of Het is as defined in any one of Tables 1 to 784, and the combination of R21, R22, r23, r24 and R of the compound corresponds in each case to one of the columns of Table A. And the combination of R1 and Het is as shown in any one of Tables 1 to 784, and the combination of the compound of the formula 2953 to 22736, formula 1.29, wherein the combination of the compound of the ruler 2!, R22, r23 'r24 and 2 5 R is in each case The following corresponds to a column of Table A and the combination of r丨 and Het is a compound of the formulae 12.737 to 23520, formula 1.30, as defined in any of Tables 1 to 784, wherein the compounds are r2i, r22, r23, r24 and R25 The combination corresponds in each case to one of the columns of Table A and the combination of Ri and Het is as defined in any of Tables 1 to 784. Tables 23521 to 24304 149027.doc • 89· 201103430 25 Formula 1.1, wherein the compound The combination of Ruler 21, Ruler 22, & 23, Ruler 24 and R25 corresponds in each case to the column of Table A and the combination of Ri and Het is as defined in any of Tables 1 to 784. Table 24305 Up to 25088 μ of the compound of formula 1.32, wherein the compound is in the range of 2丨, r22, r23, ruler and heart. Corresponding to the column of Table A and the combination of Ri and Het: a compound of the formula L259, 25872, L33, as defined in any of Tables 1 to 784, wherein the compound is R2i, R22, R23, r24 and The combination of R25 corresponds in each case to the column of Table A and the combination of Ri and Het is a compound of the formula 25873 to 26656 as defined in any of Tables 1 to 784. The combination of 2丨, r22, R23, r24 and R25 corresponds in each case to the combination of the table AmR丨 and the compound of the formulae 1 to 35, as defined in any of Tables 1 to 784, wherein the compound The combination of r2i, r22, r23, ruler 24 and R25 corresponds in each case to one of the columns of Table 8 and the combination thereof is as defined in any of Tables 1 to 784. Tables 27441 to 28224 Formula 1.36 Wherein the combination of the compound r2i, r22, ruler 23, ruler 24 and R25 corresponds in each case to the column of Table 8 and the combination of Rl#Het is as defined in any of Tables 1 to 784. To 29008 149027.doc

[SI-90·201103430 A compound of formula 1,37 wherein the combination of R21, R22, R23, R24 and R of the compound corresponds in each case to one of the columns of Table A and the combination of Ri and Het is as shown in Table 784 to The compounds of the formula L29, wherein the combination of r21, r22, r23, r24 2 5 R of the compound corresponds in each case to one of the columns of Table A and the combination of Ri and Het is as in Tables 29793 to 30576, the compounds of formula 1.39, as defined in Tables 1 to 784, wherein the combination of the rulers 2|, r22, r23, r24 and R25 of the compounds corresponds in each case to one of the columns of Table A and Ri and Het The combination is as defined in any of Tables 1 to 7 of Tables 30577 to 31360, formula 1.40, wherein the combination of the compounds 2, R22, R23, R24 and R25 corresponds in each case to Table A. One of the combinations is a compound of the formula: 31361 to 32144, formula 1.41, as defined in any one of Tables 1 to 784, wherein the combination of the compounds 2, r22, r23, r24 and R corresponds in each case to A combination of R1 and Het is as shown in any of Tables 1 to 784. Table 32145 32928 Compound of the formula 1.42 wherein the combination of R2i, R22, r23, r24 and R of the compound corresponds in each case to one of the columns of Table A and the combination of Ri and Het is as in any of Tables 1 to 784. Tables 32929 to 33712 149027.doc -91· 201103430 Compounds of the formula 1.43, wherein the combination of the compounds 1121, 1122, 1123, 24 and R25 corresponds in each case to one of the columns of Table A and the combination of R1 and Het Tables 33713 to 34496, as defined in any of Tables 1 to 784, of the compound of formula 1.44, wherein the combination of the compounds r21, r22, r23, r24 and τι 2 5 corresponds in each case to one of the columns and R1 The combination with Het is as defined in any of Tables 1 to 784, and the combination of the compounds of the formulae 21497 to 35280, wherein the combination of the compounds 21, R22, r23, r24 and R25 corresponds in each case to The combination of R1 and Het is as shown in any one of Tables 1 to 784, and the combination of r2i, r22, r23, r24 and R25 of the compound is as defined in any of Tables 1 to 784. The lower one corresponds to one of the columns of Table A and the combination of R1 and Het is as shown in Tables 1 to 784. A compound of formula 1.476, wherein the combination of R21, R22, r23, r24 and 2 5 R of the compound corresponds in each case to one of the columns of Table A and the combination of R1 and Het is as shown in the table. The compounds of the formulae 1 to 784, wherein the combination of the compounds r2i, r22, r23, r24 and R25 corresponds in each case to one of the columns of Table A and the combination of R1 and Het is defined in any one of 1 to 784. Table 34633 LS1 149027.doc -92- 201103430 A compound of the formula 4949, wherein the combination of R21, r22, r23, r24 and 2 5 R of the compound is in each case, as defined in any of Tables 1 to 784 Corresponding to a group of Table A and Het is a compound of the formula Het.l, Table 34634, Formula L49, wherein the combination of R21, R22, R23, R24 and R of the compound corresponds in each case to one of Table A and Het is Groups of formula Het. 2 Table 37635 Compounds of formula 1.49 wherein the combination of compounds r21, r22, r23, r24 and R corresponds in each case to one of Table A and Het is a formula of Het. 3 l Group Table 37636 a compound of the formula 1.49, wherein the combination of the compounds r21, r22, r23, r24 and 2 5 R is in each case The compound corresponding to the group of Table A and Het is a group of the formula Het_4, wherein the combination of R21, r22, r23, r24 and 2 5 R of the compound corresponds in each case to one of the columns of Table A and Het is Het. 5 l Group Table 37638 Compound of the formula L49 wherein the combination of the compounds r21, r22, r23, r24 and 2 5 R corresponds in each case to one of the columns of Table A and Het is a group of the formula Het. Table 37639 149027.doc -93- 201103430 25 Compound of formula L49 'wherein the compounds R21, R22, R23, R24 and 0 and in each case correspond to one of the tables A and Het is a group of the formula Het. 37640 μ Compound of formula 1.49, wherein the compound is r2, r22, r23, r24 and R, and the mouth corresponds in each case to one of the columns of Table A and Piet is a group of the formula net.8. Table 37641 Formula 149 , wherein R21, R22, R23, R24 and hydrazine of the compound, and hydrazine in each case correspond to one of the columns of Table A and Het is a group of the formula Het.9, Table 37642, a compound of the formula L49, wherein the compound R21, R22 The combination of R23, R24 and 2 5 R corresponds in each case to one of the columns of Table A and Het is a group of the formula Het. 10 a compound of the formula L49, wherein the combination of the compounds R21, R22, R23, R24 and 2 5 R corresponds in each case to one of the columns of Table A and Het is a group of the formula Het.l 1 of the formula 37644 formula 1.49, Wherein the combination of the compounds r2i, r22, r23, r24 and 2 5 R corresponds in each case to one of the columns of Table A and Het is a group of the formula Het. 1 2 Table 34545 [si 149027.doc -94- 201103430 Formula L49 a compound wherein the combination of the compounds of r21, r22, R23, R24 and 2 5 R corresponds in each case to one of the columns of Table A and Het is a group of the formula Het. 13 of the formula 37646 of the formula 1.49, wherein the compound r21 The combination of r22, r23, r24 and R corresponds in each case to one of the columns of Table A and Het is a group of the formula Het. 14 of the formula 37647. The compound of the formula 1.49 wherein the compounds are r21, r22, r23, r24 and R Combining the compounds in each case corresponding to one of the columns of Table A and Het is a group of the formula Het. 15 of the formula 37648 formula 1.49, wherein the combination of the compounds R2!, R22, R23, R24 and R25 corresponds in each case to the table One of the eight columns and Het is a group of the formula Het 16 of Tables 37649 to 37664 of the formula 1.50, wherein the compound The combination of r21, r22, r23, r24 and R25 corresponds in each case to one of the columns of Table A and is as defined in any of Tables 37633 to 37648, tables 37656 to 37680, R22, R23, R24 and Het is as shown in Table 1.51, wherein the combination of the compound r2] R 5 corresponds in each case to Table A - 37633 to 37648 - Tables 37681 to 37696 149027.doc • 95-201103430 A compound of formula 1,52 wherein the combination of R21, R22, R23, R24 and R of the compound corresponds in each case to one of Table A and Het is as defined in Tables 37763 to 3764 8 of Table 37697 To a compound of formula 1.53, wherein the combination of the compounds of the formula 2, R22, R23, r24 and 2 5 R corresponds in each case to one of the columns of Table A and the Het is as in any of Tables 37633 to 37648. Tables 37713 to 37728 are compounds of formula 1.54 wherein the combination of R21, R22, R23, r24 and R of the compound corresponds in each case to one of the columns of Table A and the Het is as defined in any of Tables 37633 to 37648. Tables 37729 to 37574 compounds of formula 1-55, wherein the compounds are r21, r22, r23, R24 The combination of R 5 corresponds in each case to one of the columns of Table A and the Het is a compound of the formula: 37.754 to 37760, formula 1.56, as defined in any of Tables 37633 to 37648, wherein the compounds are R2i, r22, r23, r24 and The combination of R corresponds in each case to one of the columns of Table A and the Het is a compound of the formula: formula 37761 to 37776, formula 1.57, as defined in any of Tables 3:7633 to 3768, wherein the compound is r2i, r22, r23 The combination of r24 and R25 corresponds in each case to one of the columns of Table 8 and the Het is a compound of the formula 37777 to 37792 149027.doc-96-201103430 Formula 1.5 8 as defined in any of Tables 3763 3 to 37648, The combination of R in each case 37633 to 37648, Tables 37793 to 37808, the compound of formula I · 5 9 , the combination of Gan R in each case 37633 to 37648 - Table 37809 to 37824 Formula I · 6 The compound of 0, the combination of complex R in each case 37633 to 37648 - the compound of Table 37825 to 37840 Formula 1.61, the combination of R in each case 37633 to 37648 - Table 37841 to 37856 Formula 1.6 2 Compound, Lu. Combination of R25 in each case; 37633 to 37648 Any of the compounds of Tables 37857 to 378872, the combination of R25 in each case 37633 to 37648 - the compounds of Tables 37873 to 378888, R21, R22, R23, R24 and corresponding to Table A And Het is as defined in the table, R21, R22, R23, R24 of the compound and R21, R22, R23, R24 corresponding to the compound of Table A and Het is as defined in the table and corresponds to Table A One of the columns and Het is as defined in the table, R21, R22, r23, r24, and R21, R22, r23, r24 corresponding to the compound of Table A and Het is as defined in the table and corresponds to Listed in Table A and Het is R21 'R22, r23, r24 as defined in the table and corresponds to one of Table A and Het is as defined in the table 149027.doc -97- 201103430 wherein R2 of the compound The lower one corresponding to the one defined in the table, wherein the compound under R21 corresponds to the one defined in Table A, wherein the compound under R21 corresponds to the one defined in Table A, wherein R21 corresponds to the table. Corresponding to R21 under the definition of one of A A compound of the formula 1-64, wherein R21 of the compound corresponds to the formula 1-64 as defined in Table A, a combination of R in each case 37633 to 37648 - a compound of the formula 1.6889 to 37904 formula 1.65, The combination of R in each case 37633 to 37648 - Tables 37905 to 37920 The compound of formula 1.66, the combination of R25 in each case 37633 to 37648 - Tables 37921 to 37936 The compound of formula 1.6 7 , the combination of R25 in each case 3763.3 To 37648 _ Tables 37937 to 37952 Compounds of Formula I · 6 8 , combinations of R 25 in each case 37633 to 37648 - Tables 37953 to 37968 Compounds of formula 69 69, combinations of R 25 in each case 37633 to 37648 Either Tables 37969 to 37984, R22, R23, R24 and Columns and Het are as shown in Table, R22, R23, R24 and Column and Het is as shown in Table, R22, R23, R24 and Column and Het is as shown in Table, R22 , R23, R24 and Rhe are as shown in Table, R22, R23, R24 and Het are as shown in Table, R22, R23, R24 and Column and Het is as shown in Table I49027.doc •98- 201103430 Formula I 70 compounds, R combination in any case 37633 to 37648 - 37985至38000 The compound of formula I · 71, the combination of R25 is in any case of 37633 to 37648 - Tables 38001 to 38016 wherein R21, R22, R23, R24 of the compound and the lower one correspond to one of Table A and the Het is as shown in the table. Wherein R21, R22, R23, R24 of the compound and the lower one corresponding to one of Table A and Het are as defined in the formula 2, wherein the compound r21 'r22, r23, r24 and R, and σ in each case corresponds to one of the tables A and is as defined in Tables 37633 to 37648, as defined in Tables 37017 to 38032, formula 1.73, wherein the compound is r21, r22, r23, ruler The combination of 24 and R25 corresponds in each case to one of the columns of Table A and the HU is as defined in any of Tables 37633 to 37648, as shown in any of Tables 38033 to 3848, compounds of formula 1.74, wherein the compounds are r21, r22, r23, r24 And the combination of R25 corresponds in each case to one of the columns of Table A and the Het is a compound of the formula 3,490 to 38,064, as defined in any of Tables 37633 to 37648, wherein the compound is R21, r22, R23, r24 and The combination of R25 corresponds in each case to one of the columns of Table A and the Het is Tables 38065 to 38080 149027.doc-99-201103430 R, as defined in any of Tables 37633 to 37648, in each case 37113 to 37648, as defined in any of the tables 38113 to 38128, the compound of the formula 1.79, wherein the compound The combination of rZ1 R25 corresponds in each case to the compound of the formulae 38129 to 38144 of the formulae defined in any one of Tables A37, 33 to 3, 7648, wherein the combination of the compounds r2] R25 corresponds in each case to the table. Table 38145 to 38160, a compound of formula 1.81, as defined in any one of A 37, 376 to 376 < 48, wherein the combination of R 2 丨 R 25 of the compound corresponds in each case to any one of the ones of Table A, 37633 to 37648. Tables 36161 to 38176 are defined, wherein R21 of the compound corresponds to a compound defined by one of Table A, wherein R21 of the compound corresponds to one of Table A, wherein R21 of the compound corresponds to Formula 1.76 of Table A, The combination of R25 is in any case of 37633 to 37648 - Table 38081 to 38096 The compound of formula 1.77, the combination of R25 is in any case of 37633 to 37648 - Tables 38097 to 38112, R·/», R22, R23, R24 and Column Het is as shown in Table, R22, R23, R24 and Het is as shown in Table, R22, R23, R24 and Column and Het is as shown in Table, R22, R23, R24 and Column and Het is as shown in Table, R22, R23, R24 and the columns and Het are as shown in the table, R22, R23, R24 and Het are as shown in Table 149027.doc -100-201103430 Formula L82, wherein the combination of the compound R21 R25 corresponds in each case to Tables 38177 to 38192 of any of Tables 37 to 37, 648, wherein the combination of compounds of rZ1 R25, in each case corresponds to one of Tables A, 37,533 to 376, M. Tables 38193 to 38208 Compounds of the formula 8484, the combination of the compounds of the formula r2丨R25, in each case corresponding to the compounds of Tables 38209 to 38824, as defined in any one of the classes 37633 to 37648, Ι·85 , wherein the combination of R2 and R25 of the compound corresponds in each case to the compound of the formula 38925 to 38240, which is defined in any one of the classes 37633 to 37648, wherein the combination of the compound R2] R25 is In the case corresponding to the table defined in any one of Tables 37633 to 3, 648 38241 to 38256 A compound of the formula 1.87, wherein the combination of the compound of the formula 2丨R25 corresponds in each case to Table 38257 to 38272 149027.doc 'R22, R23, as defined in any one of Tables 3763 to 3648. R24 and List and Het are as listed in Tables R22, R23, R24 and Column and Het is as shown in Tables R22, R23, R24 and Column and Het is as shown in Tables R22, R23, R24 and Column and Het is as shown in Table R22. , R23, R24 and the columns and Het are as shown in the table 'R22, R23, R24 and column and Het is as shown in Table-101 - 201103430 Formula I · 8 8 compounds, wherein the combination of compounds r2 1 and R25 in each case The compounds corresponding to Tables 38273 to 38288, formula 1.89, as defined in any one of Tables A37, 33 to 37,648, wherein the combination of the compounds r2i, R corresponds in each case to one of Tables A, 37,536 to 376, Table 38289 to 38304, as defined in any one of formulas 1-90, wherein the combination of Rn R of the compound corresponds in each case to the compound of formulas 38305 to 38320 of formula 1.91 as defined in any one of Tables 37633 to 37648 , wherein the combination of R:n R25 of the compound corresponds in each case to one of the tables A 3 763 3 Tables 38321 to 38336 of any of 376*48 are defined as compounds of formula 1.92, wherein the combination of R25 of the compound corresponds in each case to the table defined in any one of Tables 633 to 3764. 38337 to 38352 A compound of the formula 1.93, wherein the combination of the compound r2 and R25 corresponds in each case to Table 38353 to 38368 149027.doc H22, R23, RU as defined in any one of Tables A, 37,633 to 3 <7648 And Het is as listed in Tables R22, R23, and R24 and Het is as shown in Tables R22, R23, and R24, and Het is as shown in Table, R22, R23, and Het, and Het is as shown in Table, R22. , R23, and List and Het are listed in the table, R22, R23, r24 and Het are as shown in Table-102-201103430, R22, R23, r24 and Het are as shown in Table, R22, R23, R24 and And Het is a compound of the formula: 1.94, wherein the combination of the compounds r2, r25 corresponds in each case to the compound of the formula 38369 to 38384, formula 1.95, as defined in any one of Tables 37633 to 3764*8. , wherein the combination of the compounds r2 丨 R25 corresponds in each case to the table defined in any one of Tables A37533 to 37648 38385 to 38400, R22, R23, R24 and Het are as in the compound of the formula 1_96 'wherein the combination of the compounds ru R25 corresponds in each case to the table defined in any one of Tables A37633 to 37648 38401 to 38849 compounds of formula 1.97, corresponding to Tables 38450 to 38498 of Table 8, wherein the combination of Het and Ar of the compound is in each case and R1 is as defined in any of the formulas. The compound of 1.98 corresponds to Table 8 of Table 8 38499 to 38547. The compound of formula 1.99 corresponds to Table 38548 to 38596 of Table B, wherein the combination of Het and Ar· of the compound is in each case and R1 is as shown in the table. In any one of 1 to 49, wherein a combination of Het and Ar of the compound is in each case and R1 is as defined in any one of Tables to 49 = a compound of the formula 1.100, wherein the compound 11 is In combination with the heart, the gradation corresponds to one of the tables in Table B and R1 is as shown in any of Tables 丨 to 49. _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The following corresponds to Table B, one of Tables 38646 to 38694, and the compound of formula 1.102 corresponds to Table B. Tables 38695 to 38743 The compound of formula 1.103 corresponds to one of Table B. Tables 38844 to 38792. The compound of formula 1.104 corresponds to one of Table B. Tables 38793 to 38841. The compound of formula 1.1 0 5 corresponds to one of Table B. Tables 38842 to 38890 The compound of formula 1.106 corresponds to one of Table B. Table 38891 to 38939. The compound of formula 1.107 corresponds to one of Table B. Table 38940 to 38988. The compound of formula 1.108 corresponds to Table 38 of Table B. To 39037 'where the compound Het and Ar, the combination is in each column and R1 is as shown in Table 丨 to 49, where the compound Het and Ar, the combination in each case and the R1 system In Tables 1 to 49 - as defined by & Month, where the combination of Het and Ar of the compound is in each case and R1 is as defined in Tables i to 49, where The combination of Het and Ar of the compound is in each case and R1 is as in the range of Tables to 49, wherein the combination of Het and Ar of the compound is in each case and R] is as shown in the table. Any one of 1 to 49, wherein a combination of Het and Ar of the compound is in each case and R1 is as in Tables 丨 to 49 are defined as 'where the combination of Het and W of the compound is in each case and R1 is as defined in any of the tables: wherein 1^1 and VIII of the compound are The combination of each case and the R1 system as defined in any of the 149027.doc •104- [S] 201103430 formula 109· 109 compounds corresponds to one of the tables 39039038 to 39086, formula 1.110 In the case of a compound, it corresponds to one of the compounds of Tables 39087 to 39135. The compound of formula 1.111 corresponds to one of the compounds of Table 39136 to 39184. The compound of formula 1.112 corresponds to one of the formulas of Table 39185 to 39233 of formula 1.113. The compound corresponding to one of the following tables, table 39234 to 39282, formula 1.114, corresponding to one of the compounds, Table 39283 to 39331, formula 1.115, corresponds to one of the tables, table 39332 to 39380, formula I. _116. The following corresponds to Tables 39381 to 39429 of Table B, in which the combination of Het and Ar of the compound is in each case and R1 is as defined in any of Table U49, wherein the combination of Het and Ari of the compound is Emotion and R1 is defined as in the core of the heart, in which the compound HeW ^Ar, the combination is defined in each case and R1 is as defined in the illusion, where the compound Het and Ar, the combination is in each case and the R1 is in (5) to As defined therein, wherein the combination of Het and Ar of the compound is in each case and R1 is as defined in Tables i to 49, wherein the combination of Het and Ar of the compound is in each case and R丨Is defined in any of Table 149, wherein the compound 11 is combined with ^, in each case and R1 is as defined in the table, wherein the compound is Het and Ar' Compounds of the formula 1.117 are defined in each case and R1 is as defined in the table, wherein the combination of compounds corresponds in each case to one of the columns of Table B and R1 is as in Tables 39430 to 39478, as defined in any one of Tables 1 to 49, are compounds of the formula 1.118, wherein the combination of the compound and the heart corresponds in each case to one of the tables B and the R1 is as shown in the table. Any of the compounds defined in Tables 39479 to 39527, formula 1.119, wherein the compound is combined with the heart, in each case Corresponding to one of the columns of Table B and R is a compound of the formula: formula 1.392 to 39576, formula 1.120, as defined in any of the tables, wherein the combination of compounds H_Ar, in each case corresponds to one of the tables B and R1 is a compound of the formula: formula 39577 to 39625, formula 1.121, as defined in any one of Tables to 49, wherein the combination of the compound and the heart is in each case, and the table corresponds to the column-column in the table. In any of U49: a combination of Tables 39926 to 39674^, wherein a compound of formula 1.122 is defined in each of the following, wherein Het and hydrazine of the compound correspond to one of Table B and R1 is as shown in Table 丨4 9 of the table 39675 to 39723 ... ~ sister, in each case corresponding to the column of the table B and R, as in the table ^ - table 39724 to 39772 formula 1.124, wherein the compound and The combination of heart, in the case corresponding to the column of Table B and as shown in Table ι49 - Table 39773 to 39821 kg I49027.doc -106-201103430 Formula L125, in which the compound Het and Ar, the rainbow In each case, it corresponds to Table B - Column W is as defined in the illusion (4) of the two tables 39822 to 39870 ^ ^ The compound of the formula 1.126, wherein the combination of the compound and the ", corresponds to the column of Table B in each case and is as shown in the table (any of the cents) Table 39871 to 39919 Formula 1.127 The compound, wherein the combination of Het and Ar of the compound, in each case corresponds to the column of Table B, and is as defined in Table 399 to 39968, the compound of the formula 1.128, wherein the compound The combination of H^Ar, in each case corresponds to the column of Table B and as defined in Table u49, the compound of formula 39969 to 40017, formula 1.129, wherein the compound is combined with Ar, In the case of the table B, the column _S_rM is as defined in the formula 401 to 40066 of the formula 1.130, wherein the compound _ is combined with the column B in each case. And as defined in Table u49, the compound of Table 1.067 to 40115 is the compound of formula 1.13, and the combination of this compound and the heart of the compound in each case corresponds to the column of Table B and R1 is as shown in Table i. To the stipulations of the stipulations in Tables 4116 to 40164, the compounds of the formula J.132, in which the combinations of the compounds are in each case. The following corresponds to Table B - Column W is as in the case of Magic to - Table 40165 to 40213 149027.doc ' 107- 201103430 Formula 1.133 of the formula corresponds to Table B of one of the tables 4014 to 40262 Formula 1.134 In the case of the compound, it corresponds to Table 40263 to 40311 of Table B. The compound of formula 1.135 corresponds to one of Table B. Table 40312 to 40360. The compound of formula 1.13 6 corresponds to one of Table B. Table 40361 to 40409 Formula 1.1 3 The compound of 7 corresponds to the compound of the formula Table 40410 to 40458 of the formula B. The compound of the formula 1.138 corresponding to the table 40459 to 40507 of the formula B. The compound of the formula 1.139 corresponds to the formula 40508 to 40556 of the formula 1.140. In the case of the compound, it corresponds to Tables 40557 to 40605 of Table B, wherein the combination of Het and Ar of the compound is in each case and R1 is as defined in any of the above, wherein the compound Het and Ar The combination is in each case and R1 is as defined in any one of Tables 1 to 49, wherein the combination of Het and Ar of the compound is in each case and R1 is as in any of Tables 1 to 49. The definition of 'the compound Het and Ar, the combination in each case and the R1 system as in Any one of 1 to 49, wherein a combination of Het and Ar· of the compound is in each case and R1 is as defined in any one of Tables 1 to 49, wherein the combination of Het and Ar' of the compound In each case and R1 is as defined in any of Tables 1 to 49, wherein the combination of Het and Ar of the compound is in each case and R1 is as defined in any of Tables 1 to 49. 'where the compound Het and Ar are combined in each case and R1 is as defined in any of Tables 1 to 49 149027.doc

L SI •108- 201103430 The compound of formula 1.141, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and R1 is as defined in any of Tables 1 to 49, tables 40606 to 40654. A compound of the formula 1.142, wherein the combination of Het and Ar. of the compound corresponds in each case to one of the columns of Table B and R1 is a compound of the formula: formula: formula 165 to 40703, formula 1.143, as defined in any one of Tables 1 to 49, wherein The combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and R1 is a compound of the formula: formulas 11040 to 40752, formula 1.144, as defined in any of Tables 1 to 49, wherein the compounds are Het and Ar' The combination in each case corresponds to one of the columns of Table B and R1 is a compound of the formula: Formula 4, Formula 1.145 as defined in any one of Tables 1 to 49, wherein the combination of Het and Ar' of the compound corresponds in each case to Table B is a list of compounds of formula 1.146, wherein the combination of Het and Ar' of the compound corresponds in each case to a compound of the formula B, Formula 4, Formula 1.147, wherein the combination of Het and Ar' of the compound is in each case Corresponding to one of the tables B, list 40756, formula 1.1 The compound of 48, wherein the combination of Het and Ar' of the compound corresponds in each case to the compound of the formula 40757 149027.doc-109·201103430, formula 1.149, the combination of the ten compounds and the heart, in each case The compound corresponding to one of the following Table B, list 40758, formula 1.150, wherein the combination of Het and Ar of the compound corresponds in each case to the compound of the formula B 751, formula L 151, wherein the combination of Het and Ar of the compound In each case, corresponding to the list 5 of Table B, the formula 5, the formula 5, wherein the combination of the compound and the heart, in each case corresponds to a compound of the formula B761, formula L153, wherein the compound The combination with the heart, in each case corresponds to the compound of the formula B 762 L154 in Table B, wherein the combination of Het and Ar of the compound corresponds in each case to one of the tables B ^ Table 40763

The combination of Het and Ar' in each case 1.155, wherein the compound corresponds to Table B - List 40764 Formula L156 Compound 'Het and Ar of the compound, in each case corresponds to Table B A list of compounds of the formula: formula </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> <RTIgt; In this case, it corresponds to a compound of the formula B60, formula 1.160, in Table B, which corresponds to a compound of the formula B, formula No. 1.161, of Table B, which corresponds to a compound of the formula B. The following corresponds to a list of Table B, list 40771; a compound of formula 1.163, which corresponds to a compound of the list of Table B, Form 40772, formula 1.164, in which case corresponds to a list of Table B, 40773, wherein the compounds are Het and Ar' The combination of Het and Ar' of the compound in each case. The combination of Het and Ar' of the compound in each case. The combination of Het and Ar' of the compound in each case. The combination of Het and Ar' of the compound in each case. In each situation The combination of Het and Ar' in the compound in each case, the combination of Het and Ar' in each case. The combination of Het and Ar1 in each case is combined in each case 149027.doc -111 - 201103430 in each situation. A compound of the formula 1.165, wherein the compound of Het and hydrazine, in the case of a compound of the formula B, and the combination of Ar and the combination of Ar, in the case of the formula, in each case 1.1 66, in the case corresponding to the table A list of B, 40775, a compound of the formula 1.167, and a port v, a net of Ar^, corresponds to one of the tables B, and the ruler 1 is such as Het and A_r of the compound in Table 40776 of Tables 49 to 49, a compound of the formula 1.168, which in any case corresponds to a compound of the formula B777, formula 1.169, wherein the compound corresponds to a column of the table B, in the compound of the formula 40778, formula L17, wherein The compound is called the heart, and the group corresponds to one of the table B. The combination of the table 40779 is combined in each case of the compound of the formula im, in which the compound Het and Ar, in the case of a list of the table B 40780 Compound of formula L172, wherein compound H Et and Ar, in the case of a list of Table B, 40,781, 149,027.doc -112- [S] 201103430, a compound of formula 1.173, wherein the combination of Het and Ar' of the compound corresponds in each case to a list of Table B 40782 Compound of the formula 1.174, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and R1 is a compound of the formula: formula 1.175, as defined in any one of Tables 1 to 49, wherein the compound The combination of Het and Ar' corresponds in each case to the compound of the formula B, formula 1.176, in Table B, wherein the combination of Het and Ar' of the compound corresponds in each case to the compound of the formula 40. Wherein the combination of Het and Ar' of the compound corresponds in each case to the compound of the formula 4078, formula 1.178, wherein the combination of Het and Af of the compound corresponds in each case to one of the lists B, list 40787, formula 1.179. The compound, wherein the combination of Het and Ar' of the compound corresponds in each case to the compound of the formula 40788, formula 1.180, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the tables B. List 40789 149027 .do C-113·201103430 A compound of the formula 1.181 wherein the combination of Het and Ar' of the compound corresponds in each case to the compound of the formula 40790, formula 1.182, wherein the combination of Het and Ar1 of the compound corresponds in each case to a list of compounds of formula 1.183, wherein the combination of Het and Ar' of the compound corresponds in each case to the compound of the formula B, list of formula B, formula 1.184, wherein the combination of Het and Ar' of the compound is in each case Corresponding to a compound of the formula B </ RTI> </ RTI> <RTIgt; </ RTI> </ RTI> <RTIgt; </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> The following corresponds to a compound of the formula Table B, formula: 1.187, wherein the combination of Het and Ar' of the compound corresponds in each case to the compound of the formula 4088, formula 1.188, wherein the combination of Het and Ar1 of the compound is In the case corresponding to one of the tables B list 40797

[SI 149027.doc -114-201103430 Formula 1.89, the combination of Het and Ar' of the compound, in each case corresponds to the list &lt;RTI ID=0.0&gt;&gt; The combination with αγ' corresponds in each case to the composition &amp; matter of the list 40799, formula 1.191, wherein the combination of Het and αγ of the compound corresponds in each case to one of the expressions, Table 40800, formula 1.192 The compound, wherein the combination of Het and αγ· of the compound corresponds in each case to one of the formulas 歹I] Table 40801 Formula ΙΙ.1, wherein the combination of the compounds r21, r22, r23, r24 and R is in each case The lower one corresponds to one of the columns of Table A, Het is a group of the formula Het丨 and 1113 is 11 the compound of the formula II.1, wherein the combination of the ruler 21, r22, r23, r24 and R of the compound corresponds in each case to In one of Table 8, Het is a group of the formula Het" and Rla is a methyl group 40803. The compound of the formula II.1, wherein the combination of the compounds r21, r22, r23, r24 and R corresponds in each case to Table A. In a column, Het is a group of the formula Het ^ and Rla is an ethyl group 40804 · 149027.doc -115· 20 1103430 A compound of the formula η·1, wherein the combination of R21, R22, R23, R24 and R25 of the compound corresponds in each case to one of the columns of Table A, Het is a group of the formula Het.1 and the ruler 13 is a n-propyl group. 40805 A compound of the formula II.1, wherein the combination of R21, R22, R23, R24 and 2 5 R of the compound corresponds in each case to one of the columns of Table A, Het is a group of the formula Het.1 and Rla is an isopropyl group. Table 40806 Compound of the formula ,1, wherein the combination of the compounds r21, R22, r23, R24 and 2 5 R corresponds in each case to one of the tables A, Het is a group of the formula Het. 1 and Rla is a n-butyl group The compound of the formula 807.1, wherein the combination of the compounds r21, r22, r23, R24 and 2 5 R corresponds in each case to one of the columns of Table A, Het is a group of the formula Het.1 and Rla is Dibutyl form 40808 The compound of formula II.1, wherein the combination of the compound, r22, R23, R24 and R corresponds in each case to one of the tables A, Het is a group of the formula Het. 1 and 1113 is isobutyl Base Table 40809 A compound of the formula H.1 wherein the combination of the compounds 21, r22, r23, r24 and R25 corresponds in each case to one of the tables A, and Het is a formula Het.l Group and Rla is a third butyl group

[SI I49027.doc -116- 201103430 The compound of the formula II.1, wherein the combination of the compound of the formula 2丨, 2 5 R corresponds in each case to a group of the group A and Rla is a phenyl group 40811 formula II. A compound of 1, wherein the combination of the ruthenium 2, R of the compound corresponds in each case to a group of the group A and Rla is a compound of the formula benzyl group 40812, wherein the combination of the compound: R21, 2 5 R In each case, a group corresponding to one of the columns of Table A and rU is a methylcarbonyl group 40813. The compound of formula II.1, wherein the combination of the compounds r2i, R25 corresponds in each case to one of the groups of Table A and Rla is B. A compound of the formula II.1 wherein the combination of R21 and R25 of the compound corresponds in each case to a group of the group A and Rla is a compound of the formula propylcarbonyl group 40815, wherein the compound R21 The combination of R25 corresponds to one of the groups in Table A in each case and Rla is isopropylcarbonyl table 40816 149027.doc R22, R23, R24 and Het is R22, R23, R24 and Het of the formula Het. R22, R23, R24 and Het of the formula Het.l, R22, R23, R24 and Het of the formula Het.l R22, R23, R24 of the formula Het.l and Het are R22, R23, R24 of the formula Het.l and Het is a compound of the formula Het. 1 of 201103430 of the formula IL1, wherein the compound is r21, r22, r23, r24 And the combination of 2 5 R corresponds in each case to one of the columns of Table A, Het is a group of the formula Het.1 and Rla is a compound of the formula phenylcarbonyl 40817 formula II.1, wherein the compound is R21, R22, R23, The combination of R24 and 2 5 R corresponds in each case to one of the tables A, Het is a group of the formula Het.1 and Rla is a methoxycarbonyl table 40818. The compound of the formula II.1, wherein the compound R21, R22 The combination of R23, R24 and R corresponds in each case to one of the columns of Table A, Het is a group of the formula Het.1 and Rla is a compound of the formula ethoxylate carbonyl group 40819, wherein the compound R2i, R22, The combination of R23, R24 and R corresponds in each case to one of the columns of Table A, Het is a group of the formula Het.1 and Rla is a compound of the formula (II) of the propoxycarbonyl table 40820, wherein the compound is R21, R22, R23 The combination of R24 and R corresponds in each case to one of the columns of Table A, Het is a group of the formula Het. 1 and Rla is a compound of the formula isopropoxycarbonyl table 40821 of the formula II. The combination of the ruthenium 21, R22, R23, R24 and R25 in each case corresponds to one of the columns of Table A. Het is a group of the formula Het.l and Rla is an oxocarbonyl group.

[SI 149027.doc -118-201103430 A compound of the formula 1.1, wherein the combination of R21. and R25 of the compound corresponds in each case to a group of the group A and Rla is a methylaminocarbonyl group 40823. The compound of 1 wherein the combination of the compound r2 and R25 corresponds in each case to a group of the group A and Rla is an ethylaminocarbonyl group 40824. The compound of the formula II.1, wherein the combination of the compound r2i, R25 In each case corresponds to a group of the table A and 111 &amp; is a propylaminocarbonyl table 40825. The compound of formula II.1, wherein the combination of the compounds r2 1 , R25 corresponds in each case to one of the columns of Table A And Rla is an isopropylaminocarbonyl group 40826. The compound of formula II.1, wherein the combination of the compound r2i, R25 corresponds in each case to one of the groups listed in Table A and 1^&amp; is phenylaminocarbonyl Table 40827. The compound of formula II.1, wherein the combination of R21 and R25 of the compound corresponds in each case to one of the groups of Table A and Rla is methylsulfonyl. Tables 40828 R22, R23, R24 and Het are of the formula Het. 1 R22, R23, R24 and Het are R22, R23, R24 and Het. 1 and Het is H R22, R23, R24 and Et.1, Het is R22, R23, R24 of the formula Het.l, Het is of the formula Het. 11 R22, R23 H, Het is the formula Het. 11 149027.doc •119- 201103430 A compound of Π·1, wherein the combination of R21, r22, r23, r24 and R of the compound corresponds in each case to one of the columns of Table A, Het is a group of the formula Het.1 and Rla is an ethylsulfonyl group 40829 A compound of II.1, wherein the combination of R21, R22, R23, R24 and R25 of the compound corresponds in each case to one of the columns of Table A, Het is a group of the formula Het.1 and Ru is a propioninyl group 40830 The compound of II.1, wherein the combination of the ruthenium 2, R22, R23, R24 and 2 5 R of the compound corresponds in each case to one of the tables A, Het is a group of the formula Het.1 and R is an isopropyl group.醯基表40831 A compound of the formula II.1, wherein the combination of the compounds r21, R22, R23, R24 and R corresponds in each case to one of the tables A, Het is a group of the formula Het. 1 and Rla is a sulphur醯基表40832 A compound of the formula II.1 wherein the combination of the compounds r21, r22, R23' R24 and 2 5 R corresponds in each case to one of the columns of Table A, Het is a group of the formula Het.1 and Rla is曱Oxysulfonyl group 40833 Compound of formula II.1 wherein the combination of compounds r21, R22, R23, R24 and 2 3 R corresponds in each case to one of Table A, and Het is a group of formula Het. Rla is ethoxysulfonyl table 40834

i SI 149027.doc • 120- 201103430 The compound of the formula II.1, wherein the combination of the compounds r21, r22, r23, R24 and 2 5 R corresponds in each case to one of the tables A, and Het is a formula Het. a group and Rla is a compound of the formula propyl sulfonyl group 40835, wherein the combination of R 2 丨, R 22 , R 23 , R 24 and 2 5 R of the compound corresponds in each case to one of the columns of Table A, and Het is a formula a group of Het.i and 1113 is a compound of the formula iodine 40836, formula II. 1, wherein the combination of the compounds r21, r22, r23, R24 and R25 corresponds in each case to one of the tables A, Het Is a group of the formula Het. 1 and Rla is a phenoxysulfonyl group 40837. A compound of the formula II.1, wherein the combination of the compounds r21, r22, R23, R24 and R25 corresponds in each case to one of the tables A. Het is a group of the formula Het. 1 and Rla is a compound of the formula 40838 to 40874 of the formula II.1, wherein the combination of the compounds, r22, r23, R24 and R25 corresponds in each case to one of the tables a, R1 a A compound of the formula II.1, wherein the compound is as defined in any of the formulas: 40800 to 4083, and Het is a group of the formula Het. 2, formula 40875 to 40911, wherein the compound The combination of R21, R22, R23, r24 and R25 corresponds in each case to one of the columns of Table A, which is as defined in any of Tables 40800 to 40837 and Het is a group table 40912 of the formula Het. To 40948 -121- 149027.doc 201103430 The compound of formula II.1, the combination of R25 in any of the cases 40800 to 40837, the table 40949 to 40985 wherein the compound R21, R22, R23, R24 and below correspond to one of the tables A , R1 a is as defined in the table and Het is a compound of the formula II.1 of the formula Het.4, and the combination of the beauty R25 is not 40800 to 40837 in each case# R21 of the compound in Table 40986 to 41022 , R22, R23, R24 and corresponding to one of the tables A, Rla is as defined in the table and Het is a compound of the formula Π.1 of the formula Het.5, and the combination of the complex R25 is 40800 to 40837 in each case. R2, R22, R23, R24 of the compound in any of the tables 41023 to 41059 and corresponding to one of the tables A, 1113 is as defined in the table and Het is a group of the formula Het. 6 1 1 The compound, R25 combination, in any of the cases 40800 to 40837, each of the tables 41060 to 41096, wherein the compound R21, R22, R23, R24 and the corresponding In one of the tables A, 111 &amp; is as defined in the Table and Het is a compound of the formula II.1 of the formula Het.7, and the combination of R25 is in any case 40800 to 40837 - Table 41097 to 41133 Its compound R21, R22, R23, R24 and the lower corresponding to one of the tables A, 11丨3 are as defined in the table and Het is a compound of the formula ei.i of the formula Het.8, wherein the compound The combination of rZ1, R22, R23, r24 and R" corresponds in each case to one of the columns of Table A, and the rU is as defined in the table 40800 to 40837, and the formula is Het π a β L and Het is the formula Het .9 group table 41134 to 41170 149027.doc

LSI-122·201103430 A compound of the formula IL1, wherein the combination of the compounds R21, R22, R23, R24 and R25 corresponds in each case to the column of Table A, and the C system is as in any of the forms 40800 to 40837. And a compound of the formulae 41171 to 41207 of the formula Het.10, wherein the combination of R2丨, R22, R23, R24 and R25 of the compound corresponds in each case to one of the tables A, Rla is as defined in any of the tables 40800 to 4083, and (d) is a compound of the formula 41208 to 41244 of the formula II.1, wherein the compounds are r21, r22, r23, r24 and R25 The combination corresponds in each case to one of the columns of Table 8, Rla is as defined in any of Tables 40800 to 40837 and Het is a group of the formula Het. 12, Tables 41245 to 41281, a compound of the formula II.1 The combination of r21, r22, r23, r24 and R corresponds in each case to one of the columns of Table A, Rla is as defined in any of Tables 40800 to 40837 and Het is a group table 41282 to 41318 of the formula Het_13 A compound of the formula IL1, wherein the combination of the compounds R21, R22, R23, R24 and R25 corresponds in each case to Table A In one column, Rla is as defined in any one of Tables 40800 to 4083, and Het is a group of formulas 41419 to 41355 of the formula Het.丨4, a compound of the formula II.1, wherein the compound is r21, R22, R23, r24 And the combination of R25 corresponds in each case to one of the columns of Table A, Rla is as defined in any of Tables 40800 to 40837 and Het is a group of the formula Het. 15 Table 41356 to 41392 149027.doc -123- 201103430 A compound of the formula II.1, wherein the combination of the compounds 21, r22, r23, r24 and R25 corresponds in each case to one of the columns of Table 8, and Rla is as defined in any of Tables 40800 to 40837 and Het is a compound of the formula HeM6, in the group of 41,393 to 4,1984, a compound of the formula II.2, wherein the combination of the compounds of r21, r22, r23, r24 and R25 corresponds in each case to one of the columns of Table 8 and the combination of Rla and Het is as Tables 41985 to 42576, the compounds of formula II.3, as defined in any of Tables 40800 to 41392, wherein the combination of R21, R22, r23, r24 and R25 of the compound corresponds in each case to one of Table A and Rla and Het The combination of the compounds of the formulas 42577 to 43168, as defined in any of Tables 40800 to 41392, of the formula ,·4, The combination of R2丨, R22, R23, r24 and R25 of the compound corresponds in each case to one of the columns of Table 8 and the combination of Rla and Het is as defined in any of Tables 40800 to 41392, as defined in Tables 43169 to 43760, Formula II. a compound of 5, wherein the combination of r21, r22, r23, r24 and R25 of the compound corresponds in each case to one of the columns of Table 8 and the combination of Rla and Het is as shown in Table 43761 as defined in any of Tables 40800 to 41392. 44352 A compound of the formula II.6, wherein the combination of the compounds r21, r22, 尺23, r24 and R25 corresponds in each case to one of the columns of Table 8 and the combination of Rla and Hu is as in any of Tables 40800 to 41392. Tables 44353 to 44944 149027.doc • 124· 201103430 Compounds of the formula II.7, wherein the combination of R 2 丨, R 22 , r 23 , r 24 and R 25 of the compounds corresponds in each case to one of the columns of Table A and in combination with Het A compound of the formula II.8 as defined in any one of Tables 40800 to 41392, wherein the combination of the compounds r21, r22, r23, r24 and R25 corresponds in each case to one of the columns of Table 8 and Rla The combination is as defined in Table 4 0 0 0 0 to 413 9 2 45537至46128 A compound of the formula II.9, wherein the combination of the compounds R21, R22, r23, quaternary 24 and R corresponds in each case to one of the columns of Table A and the combination of 11丨3 and 1丨 is as shown in Table 40800. A compound of the formulae 11.129 to 46720, formula 11.1, as defined in any one of 41,392, wherein the combination of the ruler 21, ruler 22, ruler 23, ruler 24 and R25 of the compound corresponds in each case to one of the columns of Table 8 and Rla and The combination is as defined in any of Tables 40800 to 4 1392, tables 46721 to 47312

And a combination of compounds of formula 11.11, wherein the combination of compounds R1, in each case corresponds to one of Tables A, such as Tables 47013 to 47904, as defined in any of Tables 40800 to 4,392, R, R23, R24 and the combination of R1 a and Het, the compound of formula II.12, wherein the combination of the compound rS1 R corresponds in each case to one of the tables A, as shown in Table 4〇8〇0 to 41392 A compound of the formula 11.13, wherein the combination of 112丨, 1122, 1123, 尺 24 and R25 of the compound corresponds in each case to one of the tables and is defined in any one of the following Tables 47905 to 48496 149027.doc -125-201103430 The combination of 1^3 and 11 is a compound of the formulae 48497 to 49088, formula 11.14, as defined in any of the forms 40800 to 41392, wherein the combination of the ruler 2, the ruler 22, the ruler 23, the ruler 24 and the R25 of the compound is In each case, corresponding to one of the columns of Table 8 and the combination of Rla and Het is a compound of the formula 11.089 to the formula 11.15 as defined in any of the forms 40800 to 41392, wherein the compound is r21, r22, r23, ruler 24 and R25. The combination in each case corresponds to one of the columns of Table A and Rla is combined with k as shown in Table 40800 41392 to 50272, a compound of the formula 1616, wherein the combination of R2丨, R22, R23, R24 and R25 of the compound corresponds in each case to the column of Table 8 and Rla The combination is a compound of the formulae 50273 to 50864 of the formula 11.17 as defined in any one of the tables 40800 to 41392, wherein the combination of the compound 1121, the ruler 22, the ruler 23, the ruler 24 and the R25 corresponds in each case to the table - The combination of R and a is a combination of the compounds of the formula 50865 to 51456 as defined in any of the forms 40800 to 41 392, wherein the compound "之^^^^" and the combination of R25 In the case of a column corresponding to one of the Tables and a combination of Rla and fine, as defined in any of Tables 40800 to 41 392, the formula 51457 to 52084 149027.doc • 126-201103430, the compound of the formula 11.19, wherein the compound is 21 The combination of 1122, ruler 23, ruler 24 and R25 corresponds in each case to one of the columns of Table A and Rla is combined therewith as shown in any of Tables 40800 to 41; 392, Tables 52049 to 52640, Η 20 a compound in which a combination of the compounds R21, R22, r23, R24 and R25 is in each case The following corresponds to one of the columns and the combination of R丨a and Het is a compound of the formula 52641 to 53232, which is defined in any one of Tables 40800 to 41392, wherein the compound is R21, R22 'R23, r24 and The combination of R25 corresponds in each case to one of the columns of Table 8 and the combination of Rla and hydrazine is a compound of the formula IL32 as defined in any of Tables 40800 to 41392, wherein the compound is r21, r22, r23, The combination of rule 24 and R25 corresponds in each case to one of the columns of Table 8 and Rla is combined with a compound of the formula 53823 to 54416 of the formula Π.23 as defined in any of Tables 40800 to 41392, wherein the compound R2 The combination of R22, R23, R24 and R2 5 corresponds in each case to one of the columns of Table A and the combination of R丨a and he丨 is as defined in any of Tables 40800 to 41392, as shown in Tables 54417 to 55008. a compound of 24, wherein the combination of R2, R22, R23, r24 and R25 of the compound corresponds in each case to one of the columns of Table 8 and Rla is combined therewith in Tables 55009 as defined in any of Tables 40800 to 41392. 55600 149027.doc ^ 127- 201103430 Compound of formula II.25, wherein the compound The combination of r21, r22, r23, r24 and R25 corresponds in each case to one of the columns of Table A and the combination of RU and Het is a compound of the formulae 55601 to 56192, formula 11.26, as defined in any of Tables 40800 to 41392, Wherein the combination of the ruler 21, ruler 22, ruler 23, ruler 24 and R of the compound corresponds in each case to one of the columns of Table 8 and the combination is as defined in any of Tables 40800 to 41392, Table 56193 to 56784, Equation 11.27 a compound wherein the combination of the compounds 1121, 1122, han 23, ul. 24 and R25 corresponds in each case to one of the columns of Table 8 and Rla is in combination with Table 56785 as defined in any of Tables 40800 to 41392. 57376 A compound of the formula 11.28, wherein the combination of the compounds 1121, 1122, 23, 24 and R25 corresponds in each case to one of the columns of Table 8 and the combination of Rla and hydrazine is as in any of Tables 40800 to 41392. Table 57377 to 57968 Compounds of the formula 2929, wherein the combination of R21, R22, R23, r24 and R25 of the compound corresponds in each case to one of the columns of Table 8 and the combination of Rla and any of them is as shown in any of Tables 40800 to 41392. Table 57969 to 58560 defined in the formula Π·30 A compound wherein the combination of R21, R22, R23, R24 and R25 of the compound corresponds in each case to one of the columns of Table 8 and the combination of Rla and the combination is as defined in any of Tables 40800 to 41392, tables 58561 to 59152 149027 .doc [S1 -128· 201103430 Compound of formula II.3 1] wherein the combination of r21, r22, r23, r24 and R25 of the compound corresponds in each case to one of the columns of Table 8 and the combination of Rla and Het is as shown in the table. A compound of the formulae 59153 to 59734, formula 11.32, as defined in any one of 40,800 to 41,392, wherein the combination of the compounds of r21, r22, r23, r24 and 'R, in each case corresponds to one of the columns of Table A and is only The combination is a compound of the formula: 51,945 to 60,336, formula 11.33, as defined in any of Tables 40800 to 41392, wherein the combination of the ruler 21, R22, r23, r24 and R25 of the compound corresponds in each case to one of the columns of Table 8. And a combination of Rla and Het is a compound of the formula 60337 to 60982 of the formula 34.34 as defined in any one of Tables 40800 to 41392, wherein the combination of the compounds R21, R22, R23, r24 and R corresponds in each case to One of the listed persons and the combination of Rla and Het is shown in Tables 40800 to 41. Table 60983 to 61520, a compound of formula 11.35, as defined in any one of 392, wherein the combination of the ruthenium 2, r22, r23, ruthenium and R25 of the compound corresponds in each case to one of the columns of Table 8 and the combination of Rla and Het As defined in any of Tables 40800 to 413 92 - Tables 61521 to 62112 are compounds of the formula 36 wherein the combination of R21, R22, R23, r24 and R25 of the compound corresponds in each case to one of Tables 8 and Rla is in combination with a compound of the formula: 62113 to 62704 149027.doc • 129-201103430, which is a compound of the formula 11.37, wherein the combination of the compounds r21, r22, r23, r24 and R 5 is In the case of a column corresponding to one of the tables A and the combination of Rl a and Het is a compound of the formulae 62705 to 63296 of the formula 11.38 as defined in any one of the tables 40800 to 41392, wherein the compound|^21, the ruler 22, the ruler 23, The combination of Rule 24 and R25 corresponds in each case to one of the columns of Table A and the combination of Ru and Het is a compound of the formulae 13.297 to 63888 of the formula 11.39 as defined in any of Tables 40800 to 41392, wherein the compound has a size of 2丨, the combination of R22, r23, r24 and R 5 corresponds in each case A compound of the formulae 63889 to 64480, formula 11.40, as defined in any one of Tables 40800 to 41; 392, wherein the combination of the compounds r21, r22, r23, r24 and R is In the case of a combination of Table A and the combination of Ruler 1&amp; and Het are the compounds of Tables 4481 to 65072, formula 11.41, as defined in any of Tables 40800 to 41392, wherein the compounds are r21, r22, r23, ruler 24 and The combination of R25 corresponds in each case to one of the columns of Table 8 and Rla is combined with a compound of the formula 65073 to 65564, formula 11.42 as defined in any of Tables 40800 to 41392, wherein the compound has a ruler 21, a ruler 22, and a ruler. 23, the combination of ruler 24 and R25 corresponds in each case to one of the columns of Table 8 and the combination of Rla and Hu is as defined in any of Tables 40800 to 41392. Table 65 665 to 66256 J49027.doc S S1 • 130· 201103430 A compound of the formula 43 wherein the combination of R21, R22, R23, R24 and R25 of the compound corresponds in each case to one of the columns and the combination of Rla and the combination is as in any of the forms 40800 to 41392. Define compounds of formulas 66257 to 66848, Π.44, wherein The combination of R21, R22 'R23, R24 and R25 in each case corresponds to the species of the genus Mosquito and the combination of Rla and the combination of the compounds defined in Tables 40800 to 41392, as defined in any of Tables 40800 to 41392, of the formula 11.45 , wherein the combination of the ruler 21, the ruler 22, the ruler 23, the ruler 24 and the R25 of the compound corresponds in each case to one of the columns of Table 8 and the combination of Rla is as defined in any of Tables 4 to 800 to 41392. 67441 to 68032 A compound of the formula 11.46 wherein the combination of R2!, R22, r23, R24 and R25 of the compound corresponds in each case to one of the columns of Table A and the combination of Rla and Het is as in any of Tables 40800 to 41392. Tables 68033 to 68624 are defined as compounds of formula 11.47, wherein the combination of the compounds 21, r22, r23, r24 and R corresponds in each case to one of the columns of Table 8 and Rla is combined therewith as shown in Table 4 0 0 0 0 413 9 2 ─ ─ defined as the table 68625 to 69216 compound of the formula 11.48 'wherein the combination of the compound r21, r22, r23, r24 and R25 in each case corresponds to one of the eight columns and the combination of Rla and Het Tables 69217 to 69253 149027.doc 1 as defined in any of Tables 40800 to 41392 31 · 201103430 A compound of the formula II.49, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as defined in any of Tables 40800 to 40837. Table 69054 to 69290 Formula 11.50 a compound wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is a compound of the formula II.51 as defined in any one of Tables 40800 to 40837, wherein the compound The combination of Het and Ar' corresponds in each case to one of Table B and Rla is a compound of formula II.52 as defined in any of Tables 40800 to 40837, wherein Het and Ar' of the compound The combination in each case corresponds to one of the columns of Table B and Rla is a compound of the formula II.53 as defined in any of Tables 40800 to 40837, wherein the combination of Het and Ar' of the compound is in each case. The following corresponds to a column of Table B and Rla is a compound of Tables 69402 to 69438, Formula II.54, as defined in any of Tables 40800 to 40837, wherein the combination of Het and Ar' of the compound corresponds in each case to Table B. One of the columns and Rla is as shown in any of Tables 40800 to 4083 Defined in Tables 69439 to 69475

LSI 149027.doc • 132- 201103430 The compound of formula 11.55, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and the RIa is as defined in Table 69476 as defined in any of Tables 40800 to 40837. 69512 A compound of the formula 11.56, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is a compound of the formula: formula 69513 to 69549, formula 11.57, as defined in any one of Tables 40800 to 40837, wherein The combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is a compound of the formula: formula 65950 to 69586, formula 11.58, as defined in any one of Tables 40800 to 40837, wherein the compounds are Het and Ar' Combinations in each case correspond to one of the columns of Table B and Rla is a compound of the formulae 69587 to 69623, formula 11.59, as defined in any of Tables 40800 to 4083, wherein the combination of Het and Ar' of the compound corresponds in each case The compounds of the formula II.60, wherein the combination of Het and Ar' of the compound, in each case corresponds to Table B, is listed in Table B and Rla is as defined in any of Tables 40800 to 4083. One column and Rla are as shown in Tables 40800 to 4083 Tables 69061 to 69697 149027.doc -133- 201103430 of any of the formulas of formula II.61, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and the Rla is as listed A compound of the formula II.62 as defined in any one of 40,800 to 40,837, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as shown in Tables 40800 to 40837. A compound of the formula II.63 as defined in one of the formulas 69935 to 69713, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as defined in any of Tables 40800 to 40837. Tables 69972 to 69808 Compounds of the formula II.64, wherein the combination of Het and Af of the compound corresponds in each case to one of the columns of Table B and Rla is as defined in any of Tables 40800 to 40837, Tables 69809 to 69845 Formula II The compound of .65, wherein the combination of Het and Ar' of the compound corresponds in each case to one of Table B and Rla is a compound of the formula II.66 to 69882 of the formula II.66 as defined in any of Tables 40800 to 40837, Wherein the combination of Het and Ar1 of the compound corresponds in each case to One column B and Rla based 40800-40837 Table according to any one of those defined in Table 69883-69919

[SI 149027.doc • 134-201103430 The compound of formula II. 67, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as defined in any of Tables 40800 to 40837. Table 69920 to 69956 The compound of formula II.68 wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as defined in any of Tables 40800 to 40837, in the form of Tables 69957 to 69993. A compound of II.69, wherein the combination of Het and Ar' of the compound corresponds in each case to one of Table B and Rla is a compound of Table 69094 to 70030 Formula II.70 as defined in any of Tables 40800 to 40837. Wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is a compound of the formula: Tables 71.31 to 70067, formula 11.71, as defined in any one of Tables 40800 to 40837, wherein the compound Het and Ar The combination of 'in each case corresponds to one of the columns of Table B and Rla is a compound of the formulas 70068 to 70104 of the formula II.72 as defined in any of the forms 40800 to 40837, wherein the combination of Het and Ar' of the compound is in each In the case corresponding to one of the columns of Table B and Rla is as shown in Tables 40800 to 4 Table 70105 to 70141 149027.doc as defined in any of 0837.] 35 - 201103430 The compound of formula II.73, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and the R1 a system The compounds of formula II.74, as defined in any of Tables 40800 to 40837, wherein the combination of Het and Ar' of the compound corresponds in each case to one of Table B and Rla is as shown in Tables 40800 to 40837. Any of the compounds of formula II.75, defined in any one of the formulas 70179 to 70215, wherein the combination of Het and Ar' of the compound is in each case k is listed in one of Table B and Rla is in any of Tables 40800 to 40837. The compounds of formula II.76 are defined in Tables 70216 to 70252, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Ria is as defined in any of Tables 40800 to 40837. The compound of formula II.77, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as defined in any of Tables 40800 to 40837, Tables 70090 to 70326, Formula II. Compound of 78, wherein the combination of Het and Ar' of the compound is in each case Corresponding to one of the columns of Table B and Rla is a combination of Tables 70327 to 70363 as defined in any of Tables 40800 to 40837 [S1 149027.doc • 136-201103430 Formula II.79, wherein the combination of Het and Ar' of the compound In each case corresponds to one of the columns of Table B and Rla is a compound of the formula 70364 to 70400 of the formula II.80 as defined in any of the forms 40800 to 40837, wherein the combination of Het and Ar' of the compound corresponds in each case The compounds of Tables 11401 to 70437, formula 11.81, as defined in any of Tables 40800 to 40837, wherein the combination of Het and Ar' of the compound corresponds in each case to one of Table B and Rla A compound of the formula 70438 to 70474, as defined in any one of Tables 40800 to 40837, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as shown in Table 40800. A compound of the formula II.83 as defined in any of 40,837, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as in any of Tables 40800 to 40837. Compounds defined in Tables 70512 to 70548, formula 11.84 Wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as defined in any of Tables 40800 to 40837. Tables 70549 to 70585 149027.doc -137-201103430 Formula II.85 a compound wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is a compound of the formula II.86 as defined in any of Tables 40800 to 40837, wherein the compound The combination of Het and Ar' corresponds in each case to one of the columns of Table B and Rla is a compound of the formula II.87 to 70659, formula II.87, as defined in any of Tables 40800 to 40837, wherein the compound Het and Ar' The combination in each case corresponds to one of the columns of Table B and Rla is a compound of the formula II.88 as defined in any of Tables 40800 to 40837, wherein the combination of Het and Af of the compound is in each case Corresponding to one of the columns of Table B and Rla is a compound of the formula II.89 as defined in any of Tables 40800 to 40837, wherein the combination of Het and Ar' of the compound corresponds in each case to Table B. One column and Rla are as in any of Tables 40800 to 40837 Definitions Tables 70734 to 70770 Compounds of formula 11.90 wherein the combination of Het and Ar' of the compound corresponds in each case to one of Table B and Rla is as defined in any of Tables 40800 to 40837. Tables 70771 to 70807

[SI 149027.doc -138- 201103430 A compound of the formula 11.91, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as defined in any of Tables 40800 to 40837. The compound of formula II.92, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is as defined in any of Tables 40800 to 40837, Tables 70845 to 70881, Formula II. a compound of 93, wherein the combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is a compound of the formula II.94, wherein the formula 70882 to 70918 of the formula II.94 is defined in any one of the forms 40800 to 40837, wherein The combination of Het and Ar' of the compound corresponds in each case to one of the columns of Table B and Rla is a compound of the formula No. 70919 to 70955 of the formula 11.95 as defined in any one of Tables 40800 to 40837, wherein the combination of Het and Ar1 of the compound In each case corresponds to a column of Table B and Rla is a compound of the formula II.96 as defined in any of Tables 40800 to 40837, wherein the combination of Het and Af of the compound corresponds in each case to One of the tables B and Rla is as shown in Table 40800 Defined in any of 40837 149027.doc -139- 201103430

Table B No. Ar, Het No. Ar' Het Bl Ar. 2 Het.l B-33 Ar.34 Het.l B-2 Ar.3 Het.l B-34 Ar.3 5 Het.l B-3 Ar. 4 Het.l B-35 Ar.36 Het.l B-4 Ar.5 Het.l B-36 Ar.37 Het.l B-5 Ar.6 Het.l B-37 Ar.3 8 Het.l B-6 Ar.7 Het.l B-3 8 Ar.39 Het.l B-7 Ar.8 Het.l B-39 Ar.40 Het.l B-8 Ar.9 Het.l B-40 Ar .41 Het.l B-9 Ar.10 Het.l B-41 Ar.42 Het.l B-10 Ar.ll Het.l B-42 Ar.43 Het.l B-ll Ar.12 Het.l B-43 Ar.44 Het.l B-12 Ar.13 Het.l B-44 Ar.45 Het.l B-13 Ar.14 Het.l B-45 Ar.46 Het.l B-14 Ar. 15 Het.l B-46 Ar.47 Het.l B-15 Ar.16 Het.l B-47 Ar.48 Het.l B-16 Ar.17 Het.l B-48 Ar.49 Het.l B -17 Ar.18 Het.l B-49 Ar.50 Het.l B-18 Ar_19 Het.l B-50 Ar.2 Het.2 B-19 Ar.20 Het.l B-51 Ar.3 Het. 2 B-20 Ar.21 Het.l B-52 Ar.4 Het.2 B-21 Ar.22 Het.l B-53 Ar.5 Het.2 B-22 Ar.23 Het.l B-54 Ar .6 Het.2 B-23 Ar.24 Het.l B-55 Ar.7 Het.2 B-24 Ar.25 Het.l B-56 Ar.8 Het.2 B-25 Ar.26 Het.l B-57 Ar.9 Het.2 B-26 Ar.27 Het.l B-5 8 Ar.10 Het.2 B-27 Ar.28 Het.l B-59 Ar.ll Het.2 B-28 Ar .29 H Et.l B-60 Ar.12 Het.2 B-29 Ar.30 Het.l B-61 Ar.13 Het.2 B-30 Ar.31 Het.l B-62 Ar.14 Het.2 B- 31 Ar.32 Het.l B-63 Ar.15 Het.2 B-32 Ar.33 Het.l B-64 Ar.16 Het.2

[SI 149027.doc -140- 201103430 No. Ar, Het B-65 Ar.17 Het.2 B-66 Ar.18 Het.2 B-67 Ar.19 Het.2 B-68 Ar.20 Het.2 B -69 Ar.21 Het.2 B-70 Ar.22 Het.2 B-71 Ar.23 Het.2 B-72 Ar.24 Het.2 B-73 Ar.25 Het.2 B-74 Ar.26 Het.2 B-75 Ar.27 Het.2 B-76 Ar.28 Het.2 B-77 Ar.29 Het.2 B-78 Ar.30 Het.2 B-79 Ar.31 Het.2 B- 80 Ar.32 Het.2 B-81 Ar.33 Het.2 B-82 Ar.34 Het.2 B-83 Ar.35 Het.2 B-84 Ar.36 Het.2 B-85 Ar.37 Het .2 B-86 Ar.38 Het.2 B-87 Ar.39 Het.2 B-88 Ar.40 Het.2 B-89 Ar.41 Het.2 B-90 Ar.42 Het.2 B-91 Ar.43 Het.2 B-92 Ar.44 Het.2 B-93 Ar.45 Het.2 B-94 Ar.46 Het.2 B-95 Ar.47 Het.2 B-96 Ar.48 Het. 2 B-97 Ar.49 Het.2 B-98 Ar.50 Het.2 No. At' Het B-99 Ar.2 Het.3 B-100 Ar.3 Het.3 B-101 Ar.4 Het.3 B-102 Ar.5 Het.3 B-103 Ar.6 Het.3 B-104 Ar.7 Het.3 B-105 Ar.8 Het.3 B-106 Ar.9 Het.3 B-107 Ar. 10 Het.3 B-108 Ar.ll Het.3 B-109 Ar.12 Het.3 B-110 Ar.13 Het.3 B-lll Ar.14 Het.3 B-112 Ar.15 Het.3 B -113 Ar.16 Het.3 B-114 Ar.17 Het.3 B-115 Ar.18 Het.3 B-116 Ar.19 Het.3 B-117 Ar.20 Het.3 B-118 Ar.21 Het.3 B-119 Ar.22 Het.3 B-120 Ar.23 Het.3 B-121 Ar.24 Het.3 B- 122 Ar.25 Het.3 B-123 Ar.26 Het.3 B-124 Ar.27 Het.3 B-125 Ar.28 Het.3 B-126 Ar.29 Het.3 B-127 Ar.30 Het .3 B-128 Ar.31 Het.3 B-129 Ar.32 Het.3 B-130 Ar.33 Het.3 B-131 Ar.34 Het.3 B-132 Ar.35 Het.3 149027.doc -141 - 201103430 No. At, Het B-133 Ar.36 Het.3 B-134 Ar.37 Het.3 B-135 Ar.38 Het.3 B-136 Ar.39 Het.3 B-137 Ar.40 Het.3 B-138 Ar.41 Het.3 B-139 Ar.42 Het.3 B-140 Ar.43 Het.3 B-141 Ar.44 Het.3 B-142 Ar.45 Het.3 B- 143 Ar.46 Het.3 B-144 Ar.47 Het.3 B-145 Ar.48 Het.3 B-146 Ar.49 Het.3 B-147 Ar.50 Het.3 B-148 Ar.2 Het .4 B-149 Ar.3 Het.4 B-150 Ar.4 Het.4 B-151 Ar.5 Het.4 B-152 Ar.6 Het.4 B-153 Ar.7 Het.4 B-154 Ar.8 Het.4 B-155 Ar.9 Het.4 B-156 Ar.10 Het.4 B-157 Ar.ll Het.4 B-158 Ar_12 Het.4 B-159 Ar.13 Het.4 B -160 Ar.14 Het.4 B-161 Ar.15 Het.4 B-162 Ar. 16 Het.4 B-163 Ar.17 Het.4 B-164 Ar.18 Het.4 B-165 Ar.19 Het.4 B-166 Ar.20 Het.4 No. A r, Het B-167 Ar.21 Het.4 B-168 Ar.22 Het.4 B-169 Ar.23 Het.4 B-170 Ar.24 Het.4 B-171 Ar.25 Het.4 B- 172 Ar.26 Het.4 B-173 Ar.27 Het.4 B-174 Ar.28 Het.4 B-175 Ar.29 Het.4 B-176 Ar.30 Het.4 B-177 Ar.31 Het .4 B-178 Ar.32 Het.4 B-179 Ar.33 Het.4 B-180 Ar.34 Het.4 B-181 Ar.35 Het.4 B-182 Ar.36 Het.4 B-183 Ar.37 Het.4 B-184 Ar.38 Het.4 B-185 Ar.39 Het.4 B-186 Ar.40 Het.4 B-187 Ar.41 Het.4 B-188 Ar.42 Het. 4 B-189 Ar.43 Het.4 B-190 Ar.44 Het.4 B-191 Ar.45 Het.4 B-192 Ar.46 Het.4 B-193 Ar.47 Het.4 B-194 Ar .48 Het.4 B-195 Ar.49 Het.4 B-196 Ar.50 Het.4 B-197 Ar.2 Het.5 B-198 Ar.3 Het.5 B-199 Ar.4 Het.5 B-200 Ar.5 Het.5 [s] 149027.doc -142- 201103430 No. Ar, Het B-201 Ar.6 Het.5 B-202 Ar.7 Het.5 B-203 Ar.8 Het.5 B-204 Ar.9 Het.5 B-205 Ar.10 Het.5 B-206 Ar.ll Het.5 B-207 Ar.12 Het.5 B-208 Ar.13 Het.5 B-209 Ar. 14 Het.5 B-210 Ar. 15 Het.5 B-211 Ar.16 Het.5 B-212 Ar.17 Het.5 B-213 Ar.18 Het.5 B-214 Ar_19 Het.5 B-215 Ar.20 Het.5 B-216 Ar.21 Het.5 B-2 17 Ar.22 Het.5 B-218 Ar.23 Het.5 B-219 Ar.24 Het.5 B-220 Ar.25 Het.5 B-221 Ar.26 Het.5 B-222 Ar.27 Het .5 B-223 Ar.28 Het.5 B-224 Ar.29 Het.5 B-225 Ar.30 Het.5 B-226 Ar.31 Het.5 B-227 Ar.32 Het.5 B-228 Ar.33 Het.5 B-229 Ar.34 Het.5 B-230 Ar.35 Het.5 B-231 Ar.36 Het.5 B-232 Ar.37 Het.5 B-233 Ar.38 Het. 5 B-234 Ar.39 Het.5 No. At' Het B-235 Ar.40 Het.5 B-236 Ar.41 Het.5 B-237 Ar.42 Het.5 B-238 Ar.43 Het.5 B-239 Ar.44 Het.5 B-240 Ar.45 Het.5 B-241 Ar.46 Het.5 B-242 Ar.47 Het.5 B-243 Ar.48 Het.5 B-244 Ar. 49 Het.5 B-245 Ar.50 Het.5 B-246 Ar.2 Het.6 B-247 Ar.3 Het.6 B-248 Ar.4 Het.6 B-249 Ar.5 Het.6 B -250 Ar.6 Het.6 B-251 Ar.7 Het.6 B-252 Ar.8 Het.6 B-253 Ar.9 Het.6 B-254 Ar.10 Het.6 B-255 Ar.ll Het.6 B-256 Ar.12 Het.6 B-257 Ar.13 Het.6 B-258 Ar.14 Het.6 B-259 Ar.15 Het.6 B-260 Ar.16 Het.6 B- 261 Ar.17 Het.6 B-262 Ar.18 Het.6 B-263 Ar.19 Het.6 B-264 Ar.20 Het.6 B-265 Ar.21 Het.6 B-266 Ar.22 Het .6 B-267 Ar.23 Het.6 B-268 Ar.24 Het.6 149027.do C -143- 201103430 No. Ar, Het B-269 Ar.25 Het.6 B-270 Ar.26 Het.6 B-271 Ar.27 Het.6 B-272 Ar.28 Het.6 B-273 Ar. 29 Het.6 B-274 Ar.30 Het.6 B-275 Ar.31 Het.6 B-276 Ar.32 Het.6 B-277 Ar.33 Het.6 B-278 Ar.34 Het.6 B -279 Ar.35 Het.6 B-280 Ar.36 Het.6 B-281 Ar.37 Het.6 B-282 Ar.38 Het.6 B-283 Ar.39 Het.6 B-284 Ar.40 Het.6 B-285 Ar.41 Het.6 B-286 Ar.42 Het.6 B-287 Ar.43 Het.6 B-288 Ar.44 Het.6 B-289 Ar.45 Het.6 B- 290 Ar.46 Het.6 B-291 Ar.47 Het.6 B-292 Ar.48 Het.6 B-293 Ar.49 Het.6 B-294 Ar.50 Het.6 B-295 Ar.2 Het .7 B-296 Ar.3 Het.7 B-297 Ar.4 Het.7 B-298 Ar.5 Het.7 B-299 Ar.6 Het.7 B-300 Ar.7 Het.7 B-301 Ar.8 Het.7 B-302 Ar.9 Het.7 No. Ar, Het B-303 Ar.10 Het.7 B-304 Ar.ll Het.7 B-305 Ar.12 Het.7 B-306 Ar .13 Het.7 B-307 Ar.14 Het.7 B-308 Ar.15 Het.7 B-309 Ar.16 Het.7 B-310 Ar.17 Het.7 B-311 Ar.18 Het.7 B-312 Ar.19 Het.7 B-313 Ar.20 Het.7 B-314 Ar_21 Het.7 B-315 Ar.22 Het.7 B-316 Ar.23 Het.7 B-317 Ar.24 Het .7 B-318 Ar.25 Het.7 B-319 A R.26 Het.7 B-320 Ar.27 Het.7 B-321 Ar.28 Het.7 B-322 Ar.29 Het.7 B-323 Ar.30 Het.7 B-324 Ar_31 Het.7 B -325 Ar.32 Het.7 B-326 Ar.33 Het.7 B-327 Ar.34 Het.7 B-328 Ar.35 Het.7 B-329 Ar.36 Het.7 B-330 Ar.37 Het.7 B-331 Ar.38 Het.7 B-332 Ar.39 Het.7 B-333 Ar.40 Het.7 B-334 Ar.41 Het.7 B-335 Ar.42 Het.7 B- 336 Ar.43 Het.7 [si 149027.doc -144- 201103430 No. Ar' Het B-337 Ar.44 Het.7 B-338 Ar.45 Het.7 B-339 Ar.46 Het.7 B-340 Ar.47 Het.7 B-341 Ar.48 Het.7 B-342 Ar.49 Het.7 B-343 Ar.50 Het.7 B-344 Ar.2 Het. 8 B-345 Ar.3 Het. 8 B-346 Ar.4 Het.8 B-347 Ar.5 Het. 8 B-348 Ar.6 Het.8 B-349 Ar.7 Het.8 B-350 Ar.8 Het.8 B-351 Ar .9 Het.8 B-352 Ar.10 Het.8 B-353 Ar.ll Het.8 B-354 Ar.12 Het.8 B-355 Ar.13 Het.8 B-356 Ar.14 Het.8 B-357 Ar.15 Het.8 B-358 Ar.16 Het.8 B-359 Ar.17 Het.8 B-360 Ar.18 Het.8 B-361 Ar.19 Het.8 B-362 Ar. 20 Het.8 B-363 Ar.21 Het.8 B-364 Ar.22 Het.8 B-365 Ar.23 Het.8 B-366 Ar.24 Het.8 B-367 Ar.25 Het.8 B -368 Ar.26 Het.8 B-369 Ar.27 Het. 8 B-370 Ar.28 Het.8 No. Ar' Het B-371 Ar.29 Het.8 B-372 Ar.30 Het.8 B-373 Ar.31 Het.8 B-374 Ar.32 Het.8 B-375 Ar.33 Het.8 B-376 Ar.34 Het.8 B-377 Ar.35 Het.8 B-378 Ar.36 Het.8 B-379 Ar.37 Het.8 B-380 Ar. 3 8 Het.8 B-381 Ar.39 Het.8 B-382 Ar.40 Het.8 B-383 Ar.41 Het.8 B-384 Ar.42 Het.8 B-385 Ar.43 Het.8 B-386 Ar.44 Het.8 B-387 Ar.45 Het.8 B-388 Ar.46 Het.8 B-389 Ar.47 Het.8 B-390 Ar.48 Het.8 B-391 Ar. 49 Het.8 B-392 Ar.50 Het.8 B-393 Ar.2 Het.9 B-394 Ar.3 Het.9 B-395 Ar.4 Het.9 B-396 Ar.5 Het.9 B -397 Ar.6 Het.9 B-398 Ar.7 Het.9 B-399 Ar.8 Het.9 B-400 Ar.9 Het.9 B-401 Ar.10 Het.9 B-402 Ar.ll Het.9 B-403 Ar.12 Het.9 B-404 Ar.13 Het.9 149027.doc •145- 201103430 No. Ar' Het No. At' Het B-405 Ar.14 Het.9 B-439 Ar. 48 Het.9 B-406 Ar.15 Het.9 B-440 Ar.49 Het.9 B-407 Ar.16 Het.9 B-441 Ar.50 Het.9 B-408 Ar.17 Het.9 B -442 Ar.2 Het. 10 B-409 Ar.18 Het.9 B-443 Ar.3 Het. 10 B-410 Ar.19 Het.9 B-444 Ar.4 Het. 10 B-411 Ar.20 Het.9 B-445 Ar.5 Het 10 B-412 Ar.21 Het.9 B-446 Ar.6 Het. 10 B-413 Ar.22 Het.9 B-447 Ar.7 Het. 10 B-414 Ar.23 Het.9 B-448 Ar.8 Het. 10 B-415 Ar.24 Het.9 B-449 Ar.9 Het. 10 B-416 Ar.25 Het.9 B-450 Ar.10 Het. 10 B-417 Ar.26 Het. 9 B-451 Ar.ll Het. 10 B-418 Ar.27 Het.9 B-452 Ar.12 Het. 10 B-419 Ar.28 Het.9 B-453 Ar.13 Het. 10 B-420 Ar .29 Het.9 B-454 Ar.14 Het. 10 B-421 Ar.30 Het.9 B-455 Ar.15 Het. 10 B-422 Ar.31 Het.9 B-456 Ar.16 Het. 10 B-423 Ar.32 Het.9 B-457 Ar.17 Het 10 B-424 Ar.33 Het.9 B-458 Ar.18 Het. 10 B-425 Ar.34 Het.9 B-459 Ar.19 Het. 10 B-426 Ar.35 Het.9 B-460 Ar.20 Het. 10 B-427 Ar.36 Het.9 B-461 Ar.21 Het. 10 B-428 Ar.37 Het.9 B- 462 Ar.22 Het. 10 B-429 Ar.38 Het.9 B-463 Ar.23 Het. 10 B-430 Ar.39 Het.9 B-464 Ar.24 Het. 10 B-431 Ar.40 Het .9 B-465 Ar.25 Het. 10 B-432 Ar.41 Het.9 B-466 Ar.26 Het. 10 B-433 Ar.42 Het.9 B-467 Ar.27 Het. 10 B-434 Ar.43 Het.9 B-468 Ar.28 Het. 10 B-435 Ar.44 Het.9 B-469 Ar.29 Het. 10 B-436 Ar.45 Het.9 B-470 Ar.30 Het. 10 B-437 Ar.46 Het.9 B-471 Ar.31 Het. 10 B-438 Ar.47 Het.9 B-472 Ar.32 Het. 10 [si 149027.doc -146· 201103430 No. Ar' Het B -473 Ar.33 Het.10 B-474 Ar.34 Het. 10 B-475 Ar.35 Het.10 B-476 Ar.36 Het.10 B-477 Ar.37 Het.10 B-478 Ar.38 Het.10 B-479 Ar.39 Het.10 B-480 Ar.40 Het.10 B-481 Ar.41 Het.10 B-482 Ar.42 Het.10 B-483 Ar.43 Het.10 B- 484 Ar.44 Het.10 B-485 Ar.45 Het.10 B-486 Ar.46 Het.10 B-487 Ar.47 Het.10 B-488 Ar.48 Het.10 B-489 Ar.49 Het .10 B-490 Ar.50 Het.10 B-491 Ar.2 Het. 11 B-492 Ar.3 Het. 11 B-493 Ar.4 Het. 11 B-494 Ar.5 Het. 11 B-495 Ar.6 Het. 11 B-496 Ar.7 Het. 11 B-497 Ar.8 Het. 11 B-498 Ar.9 Het. 11 B-499 Ar.10 Het. 11 B-500 Ar.ll Het. 11 B-501 Ar.12 Het. 11 B-502 Ar.13 Het. 11 B-503 Ar.14 Het. 11 B-504 Ar.15 Het. 11 B-505 Ar.16 Het. 11 B-506 Ar .17 Het. 11 No. Ar, Het B-507 Ar.18 Het. 11 B-508 Ar.19 Het. 11 B-509 Ar.20 Het. 11 B-510 Ar.21 Het. 11 B-511 Ar. 22 Het. 11 B-512 Ar.23 Het. 11 B-513 Ar.24 Het. 11 B-514 Ar.25 Het. 11 B-515 Ar.26 Het. 11 B-516 Ar.27 Het. 11 B-517 Ar.28 Het. 11 B-518 Ar.29 Het. 11 B-519 Ar.30 Het. 11 B-520 Ar. 31 Het. 11 B-521 Ar.32 Het. 11 B-522 Ar.33 Het. 11 B-523 Ar.34 Het. 11 B-524 Ar.35 Het. 11 B-525 Ar.36 Het. 11 B -526 Ar.37 Het. 11 B-527 Ar.38 Het. 11 B-528 Ar.39 Het 11 B-529 Ar.40 Het. 11 B-530 Ar.41 Het. 11 B-531 Ar.42 Het 11 B-532 Ar.43 Het. 11 B-533 Ar.44 Het. 11 B-534 Ar.45 Het. 11 B-535 Ar.46 Het. 11 B-536 Ar.47 Het. 11 B-537 Ar.48 Het. 11 B-538 Ar.49 Het. 11 B-539 Ar.50 Het. 11 B-540 Ar.2 Het. 12 149027.doc -147· 201103430 No. At' Het B-541 Ar.3 Het.12 B-542 Ar.4 Het.12 B-543 Ar.5 Het.12 B-544 Ar.6 Het.12 B-545 Ar.7 Het.12 B-546 Ar.8 Het.12 B- 547 Ar.9 Het.12 B-548 Ar.10 Het.12 B-549 Ar.ll Het.12 B-550 Ar.12 Het.12 B-551 Ar.13 Het.12 B-552 Ar.14 Het .12 B-553 Ar.15 Het.12 B-554 Ar.16 Het.12 B-555 Ar.17 Het.12 B-556 Ar.18 Het.12 B-557 Ar.19 Het.12 B-558 Ar.20 Het.12 B-559 Ar.21 Het.12 B-560 Ar.22 Het.12 B-561 Ar.23 Het.12 B-562 Ar.24 Het.12 B-563 Ar.25 Het.12 B-564 Ar.26 Het.12 B-565 Ar.27 Het.12 B-566 Ar.28 Het.12 B-567 Ar. 29 Het.12 B-568 Ar.30 Het.12 B-569 Ar.31 Het.12 B-570 Ar.32 Het.12 B-571 Ar.33 Het.12 B-572 Ar.34 Het.12 B -573 Ar.35 Het.12 B-574 Ar.3 6 Het.12 No. Ar' Het B-575 Ar.37 Het.12 B-576 Ar.38 Het. 12 B-577 Ar.39 Het.12 B -578 Ar.40 Het.12 B-579 Ar.41 Het.12 B-580 Ar.42 Het.12 B-581 Ar.43 Het.12 B-582 Ar.44 Het.12 B-583 Ar.45 Het.12 B-584 Ar.46 Het.12 B-585 Ar.47 Het.12 B-586 Ar.48 Het.12 B-587 Ar.49 Het.12 B-588 Ar.50 Het.12 B- 589 Ar.2 Het. 13 B-590 Ar.3 Het. 13 B-591 Ar.4 Het. 13 B-592 Ar.5 Het. 13 B-593 Ar.6 Het. 13 B-594 Ar.7 Het 13 B-595 Ar.8 Het. 13 B-596 Ar.9 Het. 13 B-597 Ar.10 Het. 13 B-598 Ar.ll Het. 13 B-599 Ar.12 Het. 13 B-600 Ar.13 Het. 13 B-601 Ar.14 Het. 13 B-602 Ar.15 Het. 13 B-603 Ar.16 Het. 13 B-604 Ar.17 Het. 13 B-605 Ar.18 Het. 13 B-606 Ar.19 Het. 13 B-607 Ar.20 Het. 13 B-608 Ar.21 Het. 13 149027.doc -148- 201103430 At' Het B-609 Ar.22 Het.13 B-610 Ar.23 Het. 13 B-611 Ar.24 Het.13 B-612 Ar.25 Het.13 B-613 Ar.26 Het.13 B- 614 Ar.27 Het.13 B-615 Ar.28 Het.13 B-616 Ar.29 Het.13 B-617 Ar.30 Het.13 B-618 Ar.31 Het.13 B-619 Ar.32 Het .13 B-620 Ar.33 Het.13 B-621 Ar.34 Het.13 B-622 Ar.35 Het.13 B-623 Ar.36 Het.13 B-624 Ar.37 Het.13 B-625 Ar.38 Het.13 B-626 Ar.39 Het.13 B-627 Ar.40 Het.13 B-628 Ar.41 Het.13 B-629 Ar.42 Het.13 B-630 Ar.43 Het. 13 B-631 Ar.44 Het.13 B-632 Ar.45 Het.13 B-633 Ar.46 Het.13 B-634 Ar.47 Het.13 B-635 Ar.48 Het.13 B-636 Ar .49 Het.13 B-637 Ar.50 Het.13 B-638 Ar.2 Het. 14 B-639 Ar.3 Het. 14 B-640 Ar.4 Het. 14 B-641 Ar.5 Het. 14 B-642 Ar.6 Het. 14 No. Ar' Het B-643 Ar.7 Het. 14 B-644 Ar.8 Het. 14 B-645 Ar.9 Het. 14 B-646 Ar.10 Het: 14 B -647 Ar.ll Het. 14 B-648 Ar.12 Het. 14 B-649 Ar.13 Het. 14 B-650 Ar.14 Het. 14 B-651 Ar.15 Het. 14 B-652 Ar.16 Het. 14 B-653 Ar.17 Het. 14 B-654 Ar.18 Het. 14 B-655 Ar.19 Het. 14 B-656 Ar.20 Het. 14 B -657 Ar.21 Het. 14 B-658 Ar.22 Het. 14 B-659 Ar.23 Het. 14 B-660 Ar.24 Het. 14 B-661 Ar.25 Het. 14 B-662 Ar.26 Het. 14 B-663 Ar.27 Het. 14 B-664 Ar.28 Het. 14 B-665 Ar.29 Het. 14 B-666 · Ar.30 Het. 14 B-667 Ar.31 Het. 14 B -668 Ar.32 Het. 14 B-669 Ar.33 Het. 14 B-670 Ar.34 Het. 14 B-671 Ar.35 Het. 14 B-672 Ar.36 Het. 14 B-673 Ar.37 Het. 14 B-674 Ar.38 Het. 14 B-675 Ar.39 Het. 14 B-676 Ar.40 Het. 14 149027.doc •149· 201103430 No. Ar' Het B-677 Ar.41 Het. 14 B-678 Ar.42 Het. 14 B-679 Ar.43 Het. 14 B-680 Ar.44 Het. 14 B-681 Ar.45 Het. 14 B-682 Ar.46 Het. 14 B-683 Ar. 47 Het. 14 B-684 Ar.48 Het. 14 B-685 Ar.49 Het. 14 B-686 Ar.50 Het. 14 B-687 Ar.2 Het.15 B-688 Ar.3 Het.15 B -689 Ar.4 Het.15 B-690 Ar.5 Het.15 B-691 Ar.6 Het.15 B-692 Ar.7 Het.15 B-693 Ar.8 Het.15 B-694 Ar.9 Het.15 B-695 Ar.10 Het.15 B-696 Ar.ll Het.15 B-697 Ar.12 Het.15 B-698 Ar.13 Het.15 B-699 Ar.14 Het.15 B- 700 Ar. 15 ' Het.15 B-701 Ar.16 Het.15 B-702 Ar_17 Het.15 B-703 Ar.18 Het.15 B-704 Ar.19 Het.15 B-705 Ar.20 Het.15 B-706 Ar.21 Het.15 B-707 Ar.22 Het.15 B-708 Ar.23 Het. 15 B-709 Ar.24 Het.15 B-710 Ar.25 Het.15 No. Ar, Het B-711 Ar.26 Het.15 B-712 Ar.27 Het. 15 B-713 Ar.28 Het.15 B-714 Ar.29 Het.15 B-715 Ar.30 Het.15 B-716 Ar.31 Het.15 B-717 Ar.32 Het.15 B-718 Ar.33 Het.15 B-719 Ar. 34 Het.15 B-720 Ar.35 Het.15 B-721 Ar.36 Het.15 B-722 Ar.37 Het.15 B-723 Ar.38 Het.15 B-724 Ar.39 Het.15 B -725 Ar.40 Het.15 B-726 Ar.41 Het.15 B-727 Ar.42 Het.15 B-728 Ar.43 Het.15 B-729 Ar.44 Het.15 B-730 Ar.45 Het.15 B-731 Ar.46 Het.15 B-732 Ar.47 Het.15 B-733 Ar.48 Het.15 B-734 Ar.49 Het.15 B-735 Ar.50 Het.15 B- 736 Ar.2 Het. 16 B-737 Ar.3 Het. 16 B-738 Ar.4 Het. 16 B-739 Ar.5 Het. 16 B-740 Ar.6 Het. 16 B-741 Ar.7 Het 16 B-742 Ar.8 Het. 16 B-743 Ar.9 Het. 16 B-744 Ar.10 Het. 16

LSI 149027.doc -150- 201103430 No. Ar' Het B-745 Ar.ll Het.16 B-746 Ar. 12 Het.16 B-747 Ar.13 Het.16 B-748 Ar.14 Het.16 B- 749 Ar.15 Het.16 B-750 Ar.16 Het.16 B-751 Ar.17 Het.16 B-752 Ar.18 Het.16 B-753 Ar.19 Het.16 B-754 Ar.20 Het .16 B-755 Ar.21 Het.16 B-756 Ar.22 Het.16 B-757 Ar.23 Het.16 B-758 Ar.24 Het.16 B-759 Ar.25 Het.16 B-760 Ar.26 Het.16 B-761 Ar.27 Het.16 B-762 Ar.28 Het.16 B-763 Ar.29 Het.16 B-764 Ar.30 Het.16 No. Ar, Het B-765 Ar .31 Het.16 B-766 Ar.32 Het.16 B-767 Ar.33 Het.16 B-768 Ar.34 Het.16 B-769 Ar.35 Het.16 B-770 Ar.36 Het.16 B-771 Ar.37 Het.16 B-772 Ar.38 Het.16 B-773 Ar.39 Het.16 B-774 Ar.40 Het.16 B-775 Ar.41 Het.16 B-776 Ar. 42 Het.16 B-777 Ar.43 Het.16 B-778 Ar.44 Het.16 B-779 Ar.45 Het.16 B-780 Ar.46 Het.16 B-781 Ar.47 Het.16 B -782 Ar.48 Het.16 B-783 Ar.49 Het.16 B-784 Ar.50 Het.16 The groups Ar.2 to Ar.50 correspond to the above listed formulas Ar.2 to Ar.50. a group of a specific embodiment of Ar of the group, and the groups Het.l to Het.16 correspond to The groups of the specific examples of Het listed above as groups of the formulas Het.l to Het.16. The groups Ar. 2 to Ar. 50 correspond to the groups of the specific examples of Ar listed above as the group of the formulae Ar. 2 to Ar. The groups Het.l to Het. 16 correspond to the groups of the specific examples of Het listed above as groups of the formulas Het.l to Het. Among the above compounds, preferred are compounds of the formulae 1.1 to 1.24, 1.49 to 1.72, 1.97 149027.doc - 151 - 201103430 to Ι·120, 1.145 to 1.168; II.1 to Π24 and Π·49 to „.72. Among these compounds, preferred are compounds 丨丨 to ^, 149 to 1.60 &gt; I.97J.I.108 ^ 1.145^1.156; 11.1^.11.12^11.49^ ΙΙ.60. More preferably a compound! 2 , j 5 〇, j 98, 146 146, η 2 and ^ Compounds of the formulae I and II can be prepared by one or more of the following methods and variants as described in Schemes 9 to 9 and in the synthesis details. As defined above for Formulas I and II. Compounds of Formula I wherein R1 is Him is 〇 (or compounded, wherein Ria is) can be prepared by sulfonating the corresponding tri-Wow derivative IV as outlined in δ々IL Process 1. The sulfidation reaction can be carried out analogously to the known methods (for example, as described in WO 96/41804). For example, the trisap ring can be firstly removed by protonation, such as an organolithium base, such as a positive Butyllithium, tert-butyllithium or a second butyl bell 'diisopropyl amination, sodium hydride sodium or with tetramethylethylamine (TME) DA) mixed third butanol is inclined, and then the obtained anion is reacted with the element; 'I reacts with powdered sulfur. The reaction is generally carried out in an inert solvent such as ether (for example, diethyl ether, methyl tert-butyl ether, tetrahydrofuran or two). The order of the alkylene oxide, monomethoxyethane, liquid ammonia, = sulfoxide or dimethyl carbamide is not specified. The reaction temperature is not critical and can be, for example, _7 〇 to +5 〇. -70 to +0C. Alternatively, the sulfurization reaction can be carried out in the absence of a base _ by making 7 with elemental sulfur in a high boiling solvent (such as N-fluorenyl). The reaction in Ν-di-U amide is simultaneously heated to, for example, to 50 C. After completion of the reaction, for example, by adding water, such as a mineral acid (for example, dilute sulfuric acid or hydrochloric acid), acetic acid or chlorine Hydrogenation to hydrolyze the resulting mixture to obtain (four) complex

ESI 149027.doc •152· 201103430 Process 1

As outlined in Scheme 2, the triazole compound w can be prepared analogously to known methods, such as described, for example, in EP-A-〇〇65485. For example, compound 1 (wherein X is a good leaving group such as a halogen atom, especially c b or I'phenylsulfonyloxy, p-methylsulfonyloxy, trifluoroacetoxy or An alkylsulfonyloxy group, such as a methylsulfonyloxy group, can be reacted with a triazole compound 2 (wherein M is a hydrogen atom or a metal atom, especially an alkali metal atom such as Li, Na or K). In the case of MgH, the reaction is preferably tested, such as metal halides (such as sodium hydride, potassium hydride), metal hydroxides (such as sodium hydroxide, potassium hydroxide), alkali metal carbonates (such as sodium carbonate, It is carried out in the presence of potassium carbonate, carbonic acid planing or a suitable amine such as triethylamine, triethylenediamine, piperidine, pyridine, 4-dimethylaminopyridine or 4-pyrrolidinopyridine. If X is C1 or Br, the reaction can be promoted by the addition of an alkali metal iodide such as Nal or KI. The reaction is preferably carried out in a solvent. Suitable solvents are inert solvents and the reactants are quite polar to the product, for example, N,N-dimethylformamide, N,N-dimercaptoacetamide, dimethyl methacrylate, acetonitrile, benzonitrile, Ethers (such as diethyl ether, dipropyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane) and the like, and can be used in combination with other less polar inert solvents such as benzene, toluene, and Toluene, gas 149027.doc • 153- 201103430 Benzene, nitrobenzene, hexane, heptane, petroleum ether and the like. The reaction temperature is not critical and can be, for example, up to 22 Torr. Preferably, it is preferably 8 to 17 inches. Within the scope of 〇. The reaction is preferably carried out at the reflux temperature of the reaction mixture. Process 2

A, as outlined in Scheme 3 below, Compound 1 can in turn be prepared analogously to known methods, such as those described in EP-A-0 065 485 or Synthesis, 1974, I, 23. For example, ketone 3 may be reacted with the diol HO-A-OH preferably in the presence of a compound forming an azeotrope such as benzene, toluene, xylene, gas or tetra-methane, which may also act as a reaction solvent. Several hours. The ketalization reaction (ketaUzati〇n reaction) is promoted by the presence of a strong acid such as p-toluene. Subsequent halogenation of the resulting ketal 4 produces a ketal 1, wherein hydrazine is a halogen atom which, if desired, can be converted to the oxime of the compound, wherein hydrazine is a cleavage group other than halogen. Process 3

As outlined in Scheme 4 below, the ketone 3 can be similar to known methods (such as the condensation reaction of compounds 5 and 6 as described, for example, in ΕΡ-Α-0065485) [149027.doc-154-201103430, where X Is a group γ_Η or Υ-Μ, wherein Μ is a metal atom, especially an alkali metal atom such as Li, Na or Κ, and X 2 is a good leaving group such as a halogen atom such as F, C b Br or I, phenyl Sulfhydryloxy, p-toluene, S, benzyloxy, trifluoroacetoxy or alkylsulfonyloxy, such as methylsulfonyloxy, or vice versa, wherein X is a good detachment Base and parent 2 are the group YH or YM. In the case where ruthenium or X2 is γ-Η, the reaction is preferably carried out in a base such as an alkali metal hydride (for example, sodium hydride or potassium hydride), an alkali metal hydroxide (for example, sodium hydroxide or potassium hydroxide), or an alkali metal carbonate. a salt (such as sodium carbonate, potassium carbonate, carbonic acid planing) or a suitable amine (for example, triethylamine, tri-ethylamine, succinct, stipulated, 4 - dimethylamino hydrazine, 4 -吼ρ Each bite base. The ratio is determined to exist. If the leaving group X1 or X2 is C1 or ΒΙ·, the reaction can be promoted by adding an alkali metal iodide such as Nal or hydrazine. The reaction is preferably carried out in a solvent. Suitable solvents are inert solvents and the reactants are quite polar to the product, for example, N,N-didecylguanamine, n,N-dimethylacetamide, dimethyl sulphide, acetonitrile, benzoquinone , ethers (such as diethyl ether, dipropyl ether, decyl second butyl, tetrahydrofuran or dioxo) and the like, and can be used in combination with other less polar inert solvents, such as benzene, Toluene, diphenyl, benzene, nitrobenzene, hexane, heptane, petroleum ether and the like. The reaction temperature is not critical and can be, for example, in the range of 〇 to 220 ° C and preferably 80 to 170 ° C. The reaction is preferably carried out at the reflux temperature of the reaction mixture. Process 4

149027.doc -155- 201103430 As an alternative to the method of iiic, +, and 7 it in Scheme 4, as outlined in Scheme 5 below, ketone 3 (where γ  3) can be similar to EP- The process described in A-0065485 is prepared by the decarboxylation reaction of carbonate 7. It can also be prepared from hydroxylation &quot;. The base compound 8 and the following bifunctional derivative of carbonic acid 9 such as phosgene, self-acid formic acid, second-complexed carbonic acid or diphenyl-anthraquinone The hydrazine reacts and further reacts with the hydroxy compound 1 hydrazine. The decarboxylation reaction is carried out by a temperature in the range of from 7 to 120 to 220 C in an inert solvent such as diphenyl ether or ethylene glycol dimethyl ether. Flow 5 Αγ-ΟΗ 8

also

Ch3 • co2

As an alternative to the process described in Scheme 2, compound IV can be similar to that described in EP-A-0 065 485 by ketalization of the ketone with the diol HO_A-〇H, as outlined in Scheme 6 below. To prepare. The ketalization reaction can be carried out under the reaction conditions described in Scheme 3.

149027.doc -156- 201103430 As outlined in Scheme 7 below, 'ketone 11 can be similar to that described in ep-A-0065485 by compound 12 (wherein oxime is a good leaving group, such as a halogen atom, In particular, Cl, Br or I, phenylsulfonyloxy, p-tolylhydryloxy, trifluoroethyloxy or alkylsulfonyloxy, such as methyl methoxy, and triazole compounds 2 Prepared by reaction under the reaction conditions described for the reaction in Scheme 2. Compound 12 is again obtainable from the functionalization of ketone 3. Process 7

As an alternative to the process described in Scheme 2, as outlined in Scheme 8 below, Compound IV can be similar to the process described in EP-A-0 065 485 by reacting compounds 13 and 14 in the reaction conditions described for Scheme 4. Prepared by condensation, wherein X1 is a group YH or YM, wherein ruthenium is a metal atom, especially a metal atom such as Li, Na or ruthenium, and X2 is a good leaving group such as a halogen atom 'in particular Cl, Br or I a stupid base fluorenyloxy, p-decyloxy, trifluoroacetoxy or alkylsulfonyloxy, such as fluorenyloxy or vice versa where X1 is good Detached group and χ2 is a group γ_ Η or γ_Μ 〇 Process 8

Ar-χι 13

A I49027.doc -157- 201103430 As an alternative to the method described in Scheme 2, the compound Ιν (where Y is 〇(=IV')) can be similar to that described in EP-A-0065485, as outlined in Scheme 9 below. The process 'prepared by decarboxylation of carbonate vine 15 under the reaction conditions described for Scheme 5. Carbonate 15 can in turn be prepared under the reaction conditions described for the condensation reaction in Scheme 5. Process 9

Compounds 5, 6, 8, 9 and 1 which are commercially available for use in the above reactions may be made by standard methods known to those skilled in the art. The group in the above right reactant is inert to the respective reaction, which may be present in the above reaction step or may be introduced in the latter stage, for example, in the compound w, the compound of the formula I (wherein R1 is not hydrogen and (7) is ... can be prepared from the compound ^ (wherein R1 == H and m = 0). The compound of the formula I (wherein 111 is oxime and the rule 1 is Ci_Ci 〇 alkyl, haloalkyl, c2-c1 (), c2_Cl() Li dilute, C2_Ci 〇 fast radical, C 2 夂 ^ alkynyl, cvc 丨〇 cycloalkyl, cvCi 〇 halocycloalkyl, phenyl, phenyl π". alkyl, of which the last two mentioned in the group The phenyl moiety may be substituted as described above, and a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, oxime and 3 as ring members, wherein The heterocyclic ring may be substituted as described above) and may be similar to the method described in DE _A_19520098 4W 〇 96/418 〇 4 149027. doc-158-201103430 by compound I (wherein m is 0 and R1 is Η) R-LG (wherein Ri has one of the above meanings and lg is a leaving group such as a dentate group (e.g., Cl, Br, I), an anthracenesulfonate group or a mesylate group) Suitable bases are, for example, alkali metal hydrides (e.g., sodium hydride, potassium hydride) 'alkali metal hydroxides (e.g., sodium oxynitride, potassium hydroxide), alkali metal carbonates (e.g., sodium carbonate, potassium carbonate, Barium carbonate), alkali metal alkoxide (such as sodium decoxide, potassium decoxide, sodium ethoxide, potassium ethoxide, potassium butoxide) or organic lithium base (such as n-butyl lithium, second butyl lithium, third butyl) Lithium hydride and lithium isopropylamine. Generally, the reaction is carried out in a suitable solvent. Suitable/mixtures are, for example, toluene, N-decylpyrrolidone, ethers (for example, diethyl ether, tetrahydrofuran, dioxane, hydrazine, 2 _Dimethoxyethane), acetonitrile, N,N-monomethylcarbamide or diterpenoid; e wind. Or, a compound of formula I (wherein an alkyl group, a C-dentate C2-C1G alkenyl group, c2-C1Q haloalkenyl, c2-C1()alkynyl, c2-C10 haloalkynyl, &lt;: 3-(:10 cycloalkyl, C3_Ci〇 halocycloalkyl, phenyl, phenyl C4 alkyl, The phenyl moiety in the last two of the groups mentioned may be substituted as described above, and contains 1, 2 or 3 heteroatoms selected from the group consisting of ruthenium, osmium and s as 5- or 6- a saturated, partially unsaturated or aromatic heterocyclic ring in which the % by mole may be substituted as described above) may be similar to the method described in Heter(R) cycles, 23(7), 1649, 1985, by analogous to Scheme 1 The compound IV is prepared by reacting the compound IV with the disulfide Rl_s_s_Rl in the presence of a strong test. & The compound of the formula I (the pad of which is 〇 and R1 is _c(=〇)r8 or s)r8) A method similar to that described in DE-A-19617461, in which the compound 1 (wherein the claw is 149027.doc -159-201103430 0 and R) is Η) and the compound r8_c (= 〇) &gt;w, r8_c(= s) w, ruler 8, -N=C=0 or R8, _N=C = S (where r8 has the above meaning, ^ is G-C(7) alkyl or C|_Cl0 halane The base is prepared by reacting a good cleavage group such as a carbonyl group such as CM, Br, hydrazine, alkoxy group (e.g., alkoxy group, ethaneoxyquinone pentafluorophenoxy) in the presence of a base. Suitable bases are, for example, metal hydrides (e.g., sodium hydride, argon), metal hydroxides (e.g., sodium bismuth oxide, potassium hydroxide), alkali metal carbonates (e.g., sodium carbonate, potassium carbonate, carbonic acid planing). ), an alkali metal alkoxide (such as sodium methoxide, potassium decoxide, sodium ethoxide, potassium ethoxide, butanol slant) or an organic clock (such as n-butyl quinone, butyl butyl lithium butyl lithium and diiso) The lithium propylamine reaction is generally carried out in a suitable solvent. Suitable solvents are, for example, toluene, hydrazine-hydrazine, ketone, ethers (for example, diethyl ether, tetrahydrofuran, dioxane, i,2-dimethoxyethane). , acetonitrile, N,N-dimethylformamide or dimethyl sulfoxide. The compound of formula 1 (where m is 0 and is -s〇2r8) can be similar to the method described in de_a_1962059G by making the compound z (wherein (7) is . and ... is H) and the compound R^s〇2_w (wherein the rule 8 has one of the above meanings and w is a good leaving group such as a functional group (for example, C b BHoxy group (for example, formazan) The oxy group, the ethyl oxy group) or the pentafluorophenoxy group are prepared by reacting in the presence of the test, and the test is, for example, a gold test. Hydrides (such as sodium nitride, hydrogenated 1A), metal oxides (such as sodium hydroxide, IL oxidation clock), metal carbonates (such as carbonic acid steel, carbonic acid, carbonation), metal alkoxides For example, sodium methoxide, methanol unloading, sodium ethoxide, 6 alcohol unloading, third butanol unloading) or organic testing (such as n-butylation, 铉_τ^ 丞 lithium, first butyl lithium, t-butyl lithium, two Isopropylamine) Reaction I is carried out in a suitable solvent. Suitable solvents are examples [S] 149027.doc • 160· 201103430 such as toluene, N-methylpyrrolidine _, ethers (eg diethyl ether, tetrahydrofuran) Oxane, anthracene, 2-dimethoxyethane), acetonitrile, n,N-dimercaptocarbamide or diterpene smectite. Deuteration &amp; (wherein R1 is _CN) can be similar The method described in DE_A. 196204G7, wherein the compound: (where @ is G and Η) and the compound CN_W (which is rated as a good leaving group, such as a functional group (for example, Cb Br, I)) is present in the base The reaction is prepared by the following reaction. Suitable bases are, for example, alkali metal hydrides (such as sodium hydride, potassium hydride), alkali metal hydroxides (such as hydrogen and oxygen). Sodium 'potassium hydroxide), alkali metal carbonate (such as sodium carbonate, potassium carbonate, carbonic acid planing), alkali metal alkoxide (such as sodium methoxide, potassium methoxide, sodium ethoxide, potassium ethoxide, potassium butoxide) or organolithium a base (for example, n-butyllithium, lithium butoxide, first butyl quinone, diisopropylamine). The reaction is generally carried out in a suitable solvent. Suitable solvents are, for example, toluene, N-methyl η piroxone, Ethers (eg diethyl ether, tetrahydrogen, fus. South, dioxins, with -dimethoxyethane), acetonitrile, N,N-dimethylformamide or dimethyl sulfoxide. Wherein the paw is 0 and R1 is M) can be similar to the method described in de a i96i7282 'by combining the W (wherein r, h) with the amine NRaRbRe (wherein Ra, RbA Re are as defined above) or with the metal A salt such as sodium hydroxide, potassium hydroxide or copper acetate is reacted to prepare. A quinone of the formula I (wherein m is 0 and R1 is a group of the formula )) can be similar to the method described in WO 97/43269 by making the compound i (where @ is 〇 and in H) and dentate ( Especially hard) prepared in the presence of the test. Suitable tests are, for example, alkali metal hydrides (e.g., sodium hydride, hydrogenation), alkali metal hydroxides (e.g., sodium hydroxide, potassium hydroxide), alkali metal carbonates (e.g., 149027.doc • 161 201103430 Sodium, potassium carbonate, cesium carbonate, metal alkoxide (such as sodium decoxide, potassium decoxide, sodium ethoxide, potassium ethoxide, ketone, second butyl quinone, second or organic (four) (such as n-butyl) In a suitable solvent, two: lithium, lithium diisopropylamine). The reaction - the solvent is, for example, toluene, N-decyl pyrrolidone, ether (for example, diethyl « g- 7 ^ , coward Methane, dioxane, i, 2 · 2), acetonitrile, hydrazine, hydrazine, hydrazine, dimethyl hydrazine, etc. (where GJ · R1 is · ρ (= φιλι °) can be similar to 99 Prepared by the method described in /05149. 1 compound of formula II (wherein Ru is not hydrogen) can be converted to R by a reaction similar to compound 1 (wherein the conversion reaction causes the NRU group (wherein R), H) to react It is prepared as a compound of ruthenium. Compound Κ where m is "Ge 2" can be prepared by oxidation reaction from each compound K. Alternatively, compound W (where ^ 2) The protonation can be removed by the first earthworm, and then reacted with the sulfonium gas R^SC^Cl: the compound IV is prepared. The compound z (where 1 can be removed by first removing the scorpion scorpion, followed by Sulfate chloride or barium sulfate of the formula R^OSC^Cl (wherein R1 6 $ r K is selected from the group consisting of hydrazine, Ci_Ci. Institute base, Ci_c). Tetraalkyl, C2-C1G dilute, c2_Ci. Base, c2_Ci. alkynyl, C2_C|❹, alkynyl, C3-c1(), bad alkyl, C3_Cig_cycloalkyl, phenyl, phenyl-Ci_C4, wherein the last two of the groups mentioned The phenyl moiety can be substituted as described above and a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, fluorene and 8. The substitution reaction as described above is carried out from the compound IV. The right individual compound cannot be prepared via the above route, and it can be derivatized by other ES3 I49027.doc •162·201103430 compounds I and II or by the synthesis route The preparation is prepared by modification. The reaction mixture is treated in a conventional manner, for example by mixing with water, separating the phases and, if appropriate, by way of example The crude product can be purified by chromatography on alumina or tannin. Some intermediates and final products in the form of colorless or light brown viscous oil can be obtained, which do not contain volatile components or are volatilized under reduced pressure and moderately high temperature. The component is purified. If a solid and a final product are obtained, it can be purified by recrystallization or decomposition. Another aspect of the present invention relates to a compound of formula IV.

Wherein Ar, Het, A and Y have one of the above-mentioned general or especially preferred meanings given to the compound. Compound IV - aspects are useful intermediates in the preparation of compounds 1 and „ (see the above scheme), and in addition have significant fungicidal activity. Particularly preferred compound IV is formula 1 \^.1 to 1 ¥ 48 a compound, wherein the combination of R2, R, R, R and R25 corresponds in each case to one of the above Table A and Het has in each case one of the formulas Het" to Het 16; and Formula IV. Compounds of 49 to IV.96, wherein the combination of 1 and VIII]: corresponds in each case to one of the columns in Table B. 149027.doc -163· 201103430

[si 149027.doc 164 201103430

149027.doc -165- 201103430

[si 149027.doc -166 - 201103430

Among these compounds, preferred compounds IV1 to IV 24 and IV 49 to 1.72 ' are preferably compounds IV to 12 and 49 to 16, and more preferably compounds IV.2 and IV.50. The invention further relates to an agricultural composition comprising at least one of the formulas, 11 and/or compounds as defined above, or an agriculturally acceptable salt thereof, and a liquid or solid carrier. Suitable carriers and auxiliaries and other active compounds which may also be included in the compositions of the invention are as defined below. The compounds I and II and IV and the compositions of the invention are each suitable as a fungicide. It is characterized by significant effectiveness against a wide range of phytopathogenic fungi, including soil-borne fungi, especially from the following categories: m〇di〇Ph〇romycetes, and sinensis (peronoSp〇r〇rnyCetes,

Oomycetse), chytridiomycetes, Zyg〇mycetes, Ascomycetes (Bazuki-cho (10) (4), Basidiomycetes and Deuter〇mycetes (synonym, incomplete bacteria) (Fungi imperfecti). Some of its cattle are systemically effective and can be used as crop fungicides, seed dressing fungicides and soil fungicides for crop protection. In addition, it is suitable for control Harmful fungi, especially fungi that occur in the roots of wood or plants. Chemicals &amp; I, sputum and IV and compositions of the invention are particularly important in controlling a large number of phytopathogenic fungi: fungi on various cultivated plants, such as cereals, for example Wheat, rye, barley, triticale, oats or rice bran; beet, 149027.doc •167· 201103430 For example, (iv) beet or (iv) beet; fruit, such as pome fruit, stone fruit or soft fruit (soft fnm), for example, frequency Fruit, pear, plum, peach, almond, peach, strawberry, raspberry, blackberry or gooseberry; legumes such as lentils, cowpea, sage or soybean; oil crops such as canola, fennel撖:, hollyhock, coconut, cocoa, 麻麻, oil palm, groundnut or soy melon, such as pumpkin, courgette or melon; fiber plant, such as cotton, linen, hemp or jute; citrus fruit, Such as oranges, 4 Dingjia, Sui Hung pomelo or mandarin; vegetables, such as vegetables, borage, barrels, kale, carrots, onions, bananas, bells, melons or peppers; laurel plants, Such as clock pear, cinnamon or camphor, energy and raw plant, such as corn, soybean, 'yield, ginseng or oil palm; corn; tobacco; nut, bake, tea, 1; vine (salty and grape juice) Rattan; hops; 'skin; natural rubber or ornamental plants and forestry plants such as flowers: shrubs, broadleaf trees or evergreen trees' such as conifers; and plant propagation materials ^ fungi, such as seeds, and crop materials of such plants Preferably, the compounds and their compositions are used to control a large number of fungi on the following crops: field crops such as potatoes, sugar beets, buckwheat, rye, barley, swallow , rice, corn, cotton, soybean rape, ugly, sunflower, coffee or Ganshui water; ornamental plants; or vegetables, @ h # '' 馼 未 不 4 such as courgettes, tomatoes, beans or pumpkins. The term "plants" refers to all plant reproductive parts that can be used to propagate plants, such as in the plant and in vegetative plant material, such as cuttings and tubers (eg potatoes). This includes seeds, Rhizomes, bulbs, rhizomes, shoots, young βt shells, young shoots and other parts of plants, "(iv) I49027.doc -168- 201103430 and seedlings, which are transplanted after germination or after exposure of the soil. These ranks can also be protected by all or part of the treatment by dipping or pouring before transplantation. Preferably, the plant propagation material is treated with Compounds I, II, and IV, and combinations thereof, respectively, for controlling a large number of fungi on the following: mites, such as wheat, rye, barley, and oats; rice, corn, cotton And soybeans. The term "cultivated plants" is understood to include plants that have been modified by breeding, mutation induction or genetic engineering, including but not limited to commercially available or developing agricultural biotechnology products (reference: http://www. Bio.org/ speeches/pubs/er/agri_products.asp). Genetically modified plants are plants whose genetic material has been modified by the use of recombinant DNA techniques which are not readily obtainable by cross-breeding, mutation or natural recombination in nature. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant to modify certain properties of the plant. Such genetic modifications also include, but are not limited to, proteins, for example, by glycosylation or polymer addition (such as prenylated, acetated or farnesylated moieties or PEG moieties), Post-translational modification of the oligopeptide or polypeptide.

Modified plants have been designed by breeding, mutation induction or genetic engineering. Due to conventional breeding or genetic engineering methods, for example, tolerance to the application of specific classes of herbicides, such as hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor; acetaminophen lactate (ALS) inhibitor, such as sulfonylurea (see, for example, US 6,222,100, WO 01/82685, WO 00/26390, WO

97/41218 'WO 98/02526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/14357 &gt; WO 149027.doc -169-201103430 03/13225, WO 03/14356, WO 04/ 16073) or imidazolinones (see, for example, US 6,222,100, WO 01/82685, WO 00/026390 'WO 97/41218, WO 98/002526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/ 014357, WO 03/13225, WO 03/143 56, WO 04/16073); enol acetone oxalic acid-3-phosphate synthase (EPSPS) inhibitors, such as glyphosate (see, for example, WO 92/) 00377); a glutamate synthase (GS) inhibitor such as glufosinate (see, for example, EP-A 242 236, EP-A 242 246) or an oxynil herbicide (see, for example, US) 5,559,024). Conventional breeding methods (mutation induced) have rendered several cultivated plants tolerant to herbicides, such as Clearfield® Summer Canola (Canola, BASF SE, Germany) to „米„坐琳酮 (eg, Imazamox) Financial acceptability. Genetically engineered methods have been used to make cultivated plants (such as soybeans, cotton, corn, sugar beets, and canola) tolerant to herbicides (such as jiacaosai and chlorpyrifos), some of which are under the trade name RoundupReady® , Monsanto, s A ) and

LibertyLink® (commercially available from Bayer CropScience, Germany) also includes plants capable of synthesizing one or more insecticidal proteins by using recombinant DN A technology, especially from the genus Bacteroides ( Genus Bacillus), especially a protein from BaeUlus thuringiensis, such as δ-endotoxin, for example, CryJA(b),

CrylA (c), CrylF, CryIF (a2), CryIIA (b), CryliiA,

CrylllB (bl) or Cry9c; vegetative insecticidal protein (Vlp), such as VIP1, VIP2, VIP3 or VIP3A; colonizing nematode bacteria (eg, luminescence)

[SJ 149027.doc -170-201103430 \na〇aus willow.) or the insecticidal protein of the nematophagous bacillus genus (us spp.)); the toxin produced by animals, L蝎 mother &amp; , wasp-toxin or other insect-specific neurosteroids - toxins produced by fungi such as streptomyces toxins, plant lectins such as cowpea or barley lectin; lectins; protease inhibitors such as membrane protease inhibitors, silkamine Acid protease inhibitors, patatin inhibits cis-cysteine protease inhibitors or papain inhibitors; ribosome-inactivated proteins (RIP), such as M-toxin, maize R Rip, acacia, Loofah venom protein, sap〇rin or diarrhea venom protein (bryodin); steroid metabolism enzymes, such as hydroxy steroid oxidase, dermal steroid tear-glycosyltransferase, cholesterol oxidase, ecdysone inhibition Agent or HMG-CoA-reductase; ion channel blocker, such as sodium channel or calcium channel blocker; juvenile hormone esterase; diuretic hormone receptor (heterologous genus protein receptor); Biphenyl Group synthase, chitinase (pumila chitinase and) or a glucanase. In the context of the present invention, it is also expressly understood that such insecticidal proteins or toxins are understood to be protoxins, hybrid proteins, truncated or otherwise modified proteins. Hybrid proteins are characterized by novel cascades of protein domains (see, for example, WO 02/015701). Other examples of such toxins or genetically modified plants capable of synthesizing such toxins are disclosed, for example, in EP-A 374 753, WO 93/007278, WO 95/34656, EP-A 427 529, EP-A 451 878, Methods for producing such genetically modified plants in WO 03/18810 &amp; WO 03/52073 are generally known to those skilled in the art and are described, for example, in the above publication. Such insecticidal proteins contained in genetically modified plants allow plants which produce such proteins 149027.doc 171 201103430 to tolerate harmful pests from all: arthropod taxa, especially beetles (Coleoptera (C〇le〇) Ptera)), two-winged insects (Diptera altera) and moths (Lepid〇ptera), and nematodes (Nematoda). Genetically modified plant lines capable of synthesizing one or more insecticidal proteins are described, for example, in the above publication, and some of them are commercially available: such as YieldGard® (a corn cultivar producing Cryl Ab toxin), YieldGard® Plus (creating CrylAb) And Cry3BM toxin corn cultivar), Stadink® (Cry9c toxin-producing corn cultivar),

Herculex® RW (Corn cultivar producing Cry34Abl, Cry35Abl and phosphatidylcholine _N_acetyltransferase [PAT]); NuC〇TN® 33B (Cry 1 Acetate cotton cultivar), B〇 Ligard® 1 (cotton cultivar producing cryiAc toxin), Bollgard® II (cotton cultivar producing CrylAc and Cry2Ab2 toxin); viPCOT® (cotton cultivar producing VIP-toxin); NewLeaf® (producing Cry3A toxin) Horses cultivar); Bt-Xtra®, NatureGard®, KnockOut®, BiteGard®, Protecta®, Btll available from Syngenta Seeds SAS, France (eg Agrisure 8CB) and Btl76 (corn producing CrylAb toxin and PATS#) Cultivars), from Syngenta Seeds SAS, France's MIR604 (a maize cultivar producing a modified form of Cry3A toxin' reference WO 03/018810), MON 863 purchased from Monsanto Europe SA, Belgium (to produce a Cry3Bbl toxin) Corn cultivar), IPC 531 (a cotton cultivar producing a modified form of CrylAc toxin) purchased from Monsanto Europe SA, Belgium, and from Pi〇neer Overseas Corporation, Be LG purchased 1507 (produced CrylF toxin 149027.doc -172- 201103430 and corn cultivar of PAT enzyme). Also included are plants which can be synthesized by using recombinant DNA techniques - or a plurality of proteins which increase the resistance or resistance of their plants to bacterial, viral or fungal pathogens. Examples of such proteins are the so-called "path 〇 genesis-reiated proteins" (PR proteins, see for example EP-A 392 225), plant disease resistance genes (for example, potato cultivars, which are used for Against a resistance gene derived from the potato Phytophthora in the wild potato diploid species (Solanum bulbocastanum) or T4-lysozyme (for example, a potato cultivar capable of synthesizing such proteins, such as against pear fire damage (Erwinia amylv) 〇ra) increased bacterial resistance). Methods of making such genetically modified plants are generally known to those skilled in the art and are described, for example, in the above publication. Also included are plants capable of synthesizing one or more proteins by using recombinant DNA techniques that increase productivity (eg, biomass production, grain yield, powder content, oil content or protein content), drought tolerance Salt tolerance or tolerance to other growth limiting environmental factors or to fungi, bacterial or viral pathogens of pests and their plants. In addition, in order to specifically improve the nutritional status of humans or animals, plants including varying amounts of inclusions or novel inclusions by using recombinant DNA technology, for example, produce long-chain ω_3 fatty acids or unsaturated ω which promote health. -9 fatty acid oil crops (eg, Nexera® canola, D〇w

Agro Sciences, Canada) 〇 In addition to 'specifically improving the production of raw materials' also includes plants containing varying amounts of inclusions or novel inclusions by using recombinant DNA techniques, for example, 149027.doc-173-201103430 An increased amount of amylopectin potato (eg, Amflora® potato, BASF SE, Germany). Compounds I, II and IV and their compositions are especially suitable for controlling the following plant diseases: Albugo spp. (white rust): in ornamental plants, vegetables (eg 'A. Candida') And to the aunt (for example, A. tragopogonis); Aiternaria spp. (Alternaria leaf spot): in vegetables, rape (salty moss) A. brassicola or brassicae), sugar beet (A. tenuis), fruit, rice bran, soybean, potato (for example, A. souni or A. souni) A. altemata, tomato (for example, Alternaria alternata or Alternaria alternata) and wheat; sugar beet and vegetable root rot (Aphan〇myces spp. ); Asc〇chyta spp on moss and vegetables, such as A. tritici (anthrax) on wheat and barley ring disease (a hordei) on barley Bip〇iaris spp and Drechslera spp. (sexual state: genus genus (c) ochHobolus spp.)), for example, southern leaf blight on corn (d. maydis) or northern leaf blight (corn worm (7) found ^^^), for example, on moss Spot disease (B. s〇r〇kiniana) and, for example, rice umbilical (B me) on rice and turf; on the scorpion (used on the evening or on barley) Powdery mildew (B) umeria graminis (formerly known as Erysiphe graminis) (powder disease); fruits and fruit (eg, strawberries), vegetables (eg, lettuce, carrots, sprouts and kale), canola, [ S] 149027.doc -174- 201103430 vine planting plants and wheat vines (B〇trytis cinerea) (sexual sorrow: B〇try〇tinia fuckeiiana: gray mold), lettuce Bremia lactucae (downy mildew), broadleaf and sling, cerat0Cystis spp. (synonym Ophiostoma spp.) Rotting or withering), such as C. uhni (Netherlands eucalyptus) on the eucalyptus; Cerc〇sp〇ra spp. Spot disease): in corn (for example, gray leaf spot: C. zeae-maydis), rice bran, sugar beet (for example, C. beticola), sugar cane, vegetables , coffee, soybean (for example, C_ sojina or C kikuchH) and rice blast; Clad 〇Sporium spp.: in tomato (for example, Phytophthora (C. fulvum). Foliar) and mites, such as C. herbarum (smut) on wheat; Claviceps pUrpUrea on cereals (ergots) ); genus genus (c〇cMi〇b〇lus spp) (all-sex: Helminthosp〇rium) (leaf leaf spot): in corn (corn corn snail cavity) C. carbonum), terpenoids (eg, C. sativus, asexuality: b sorokiniana) and rice (eg, uterine spore cavity) Cmiyabeanus, asexual state: Helminthosporium ssp. (H. %)); Colletotrichum SPP. (Polymorphism: Anthracnose (Glomerella) Spp.)) (anthrax): in cotton (for example, cg〇SSypii), corn (for example, c. graminic〇la: anthrax stem rot), soft fruit, Horse yam (eg 'c. coccodes: black spot disease'), beans (eg, Bean thorn spores (c. 149027.doc -175 - 201103430 Π - test nUm)) and soybeans (eg , flat head thorn spore (c plus dirty her) or glue? On C. gi〇e〇sp〇ri〇ides); Cono-spp., for example, Rhizoctonia solani (cϋϋ) on rice paddy; Sheath blight; Soybean And ornamental plants on the genus C. rynesp〇ra cassiicola (leaf leaf spot); Cyclabium conium spp., for example, the Phytophthora indicum on the eucalyptus c 〇leaginum); Cylindr 〇carpon spp. (eg, fruit squamous cell carcinoma or vine decline) 'sexual state: Nectria spp. or new plexus Ne〇nectria spp.): in fruit trees, vines (for example, c liriodendri, having a sexual state: Neonectria liriodendri: blackfoot disease) On ornamental plants, Dematophoranecatrix (sexual state: Rosallian neeatrix) (root rot and stem rot); Diaporthe spp. For example, d. phase〇l〇rum (dumping disease) on soybean; Helminthosporium (synonym Having a sexual state: Pyrenophora: in corn, cereals, such as barley (for example, D. teres, net spot disease) and wheat (for example, umbilical cord blood snail) (D. tritici-repentis, brown spot), rice and turf; Esca (top blight, dry blight) on vines, by Listpipora punctata (Phellinus punctata), Mediterranean bacterium (F. Mediterranea), Phaeomoniella chlamydospora (early Phaeoacremonium chlamydosporum), Phaeoacremonium aleophilum and/or Botryosphaeria obtusa

[SI 149027.doc -176· 201103430 caused by the genus Elsinoe spp.: in the fruit of the fruit (E. pyri), soft fruit (P. sylvestris (E veneta) ): anthracnose) and vines (Ε·ampelina: anthracnose); Entyloma oryzae (leaf smut) on rice; (Epicoccum spp.); Erysiphe spp. (powder disease): in sugar beet (E. beetiae), vegetables (eg, pea powdery mildew (E. pisi) ), such as melons (such as 'E. cichoracearum), cabbage, rapeseed (such as 'E. cruciferarum'); in fruit trees, vines and plant trees There are many, Eutypa iata (Cell cancer or top blight, asexuality: Cyt〇sp〇rina Uu) (synonymous 5 Division 百 匕 匕 匕 抱 ( Libertella blepharis))); Exaserohilum spp. 'synonymous on maize (eg 'E turcicum') Helminthosporium); various kinds of Fusarium on plants (Fusarium spp) (sexual stage: the genus Fusarium (Gibberella spp))

(&gt;Peripheral rot, root rot or stem rot), such as F graminearum or F CUlm〇rUm on roots (such as wheat or barley) (root rot) Disease, scab or head blight), F. oxysporum on tomato, Fusarium oxysporum on soybean, and Fusarium oxysporum on corn (F. verticillioides); apes (salmon) wheat or barley) and Gaeumann〇myCes graminis on corn (total eclipse); Gibbere Ua spp.: in mites ( For example, G. zeae (G. zeae) and rice blast (such as G. fujikuroi 'mycosis); vines and other plants 149027.doc -177- 201103430 anthracnose (Glomerella cingulata) and cotton anthracnose (g. gossypii); Granstaining complex on rice, Guignardia bidwellii (black rot) on vine; Genus plants and the genus Gymnosporangium spp., such as Sabine rust on pears (G sab Inae) (rust); Helminthosporium on corn, alfalfa and rice blast (synonym umbilical umbilical cord, sexual state: Helminthosporium); Helicobacter spp. Hemileia vastatrix (coffee leaf disease); Isariopsis clavispora on the vine (synonym Cladosporium vitis); Soybean and cotton on the genus Macrophomina Phaseolina, Macrophomina phaseoli); Microdochium nivale (synonymous with Fusarium nivale) on moss (eg wheat or barley) (snow mold) ); on the soybean, Huanghua and silk shell (Microsphaera diffusa) (powder disease); brown rot fungus (Monilinia)

Spp.) 'For example, M. laxa on the fruit and other Rosaceae plants, m. fructicola and M. fructigena (flower rot) Disease and blight (bl〇〇m and twig blight), brown rot); cereals, bananas, soft fruits and groundnuts (Mycosphaerella spp.) 'such as wheat on the bacterium (M. Graminicola) (sexless state. Sept〇ria tritici, Septoria blotch), or Filipino bacterium (μ. fijiensis) on banana (black banana leaf spot) ); downy mildew (per〇n〇Sp〇ra Spp) (downy mildew). in cabbage (such as mossy rose disease (p. brassicae), rapeseed (example)

[SI 149027.doc -178- 201103430 such as parasitic downy mildew (p_parasitica), onions (such as p. destructor), tobacco (tobacco downy mildew (p仏 to (10)" and soy (such as soy cream) P. manshurica; Phakopsora pachyrhizi and p meibomiae (soybean rust) 'Phialophora spp.: for example, vines (eg, P. tracheiphila and p tetraspora) and soybeans (eg, p gregata: stem rot); black stalks on rapeseed and kale Mold (ph〇ma lingam) (root rot and stem rot), and P. betae (root rot, leaf spot and blight) on sugar beet; Phomopsis spp.: in sunflowers, vines (eg P_ viticola: can and leaf spot) and soybeans (eg stem rot. Phytophthora sojae (P) Phase〇li), sexual state: Diaporthe phaseolorum; jade on corn Physoderma maydis (brown spot disease); Phytophthora spp. (wild 'root' leaf, fruit and stem rot) on various plants: such as peppers and melons (eg peppers) P. capsici), soybean (eg P. megasperma (P. sojae)), horse yam and tomato (eg P. infestans: late blight) and broadleaf trees (eg P. ramorum: oak tree death; plasm〇di〇phora brassicae (root swollen disease) on cabbage, rapeseed, radish and other plants; (Plasmopara spp.), for example, P. viticola (vine vine downy mildew) on vines, and p. halstedii on sunflower; Rosaceae, snake麻子,仁•179· 149027.doc 201103430 The fruit and soft fruit on the genus Pseudomonas (p〇d〇sphaera -) (powder disease), such as the white fruit of the genus Pseudomonas sinensis (p Leuc〇tricha); Polymyxa SPP., for example in cereals (such as barley and wheat) 〇 〇 · gram gram gram ( 及 及 及 及 及 及 及 ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ps ps ps ps ps ps ps ps ps ps 〇trich〇ides) (rotary disease, sexuality: Tapesia yaUundae); Pseudomonas spp. (Pythromycin) on various plants, such as P. cubensis on melons Or P. humiH on hops; Pseud〇pezicuia tracheiphilaK red fire disease or r〇tbrenner, asexual: bottle mold (Phialophora)); Puccinia spp. (rust) on various plants, such as P. triticina (brown rust or leaf rust) on cereals (eg wheat, barley or rye) ), P. striiformis (strip rust or yellow rust), P hordei (dwarf rust), p graminis (stem rust or Black rust) or P. recondita (brown rust or leaf recorded disease) and on bamboo shoots Puccinia genus (such as P. asparagi); Pyren〇ph〇ra triti Cirepentis on wheat (disorder: Drechslera triticirepentis) (Brown spot) or Pteres on barley (net spot disease); Pyricularia spp., such as P. oryzae on rice (sexual state) : Magnaporthe grisea, rice cancer) and P. grisea on turf and cereals; turf, rice 149027.doc -180· 201103430 縠, corn, wheat, cotton, rape, sunflower Pythium spp. (Pythium blight) (such as P. ultimum or P. aphanidermatum) on soybeans, sugar beets, vegetables, and various other plants. Ramuiaria spp., such as R. collocygni on barley (Saccharomyces cerevisiae leaf spot, physiological leaf spot) and sugar beet on sugar beet R beticola; cotton, rice bran, potato, turf, corn, canola, potato, sugar Rhizoctonia spp_ on sugar beets, vegetables and various other plants such as R. s〇iani (root rot and stem rot) on soybean, and stalk core on rice blast Phytophthora (strain) or R. cerealis (spring blight) on wheat or barley; lychee on strawberries, carrots, kale, vines and tomatoes Rhizopus stolonifer (black mold, soft rot); Rhizochasporium secalis (brown spot) on barley, rye and black wheat Sarocladium oryzae) and S. attenuatum (sheath rot); Sclerotinia spp. (stalk rot or white mold): in vegetables and field crops, such as rapeseed, On the day (such as S. sclerotiorum) and soybeans (such as Sr〇lfsii or Sclerotinia sclerotiorum); Saccharines (brown spots) on wheat, and 8 uhici on wheat (shell needles) Plaque disease) and S. n〇d〇rum (synonym Stagonospora nodorum) (shell occidentosis); vines Uncinula necator (synonym grape white 149027.doc -181 - 201103430 Erysiphe necator) (powder disease, asexuality: Oidium tuckeri); Genus (Setospaeria spp.) (leaf blight) · in corn (such as S. turcicum, synonym Helminthosporium turcicum) and turf; Sphacelotheca Spp.) (Smut): in the corn (such as S. reiliana: head smut), sorghum and sorghum on the melon (Sphaerotheca fuliginea) (Spear white) "Sp〇ng〇spora subterranea" (white sputum) and viral diseases transmitted thereby; the genus of the genus Bacillus on cereals, such as wheat S. nod〇rurn (S. nod 〇 urn ( ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Lept〇sphaeria nodorum) [synonym phae〇sphaeria nodorum]; Synchytrium end〇bi〇ticum (potato cancer); (Taphrina spp), such as T. def0rmans on the peach (throat leaf disease) and T. pruni on the plum (risk fruit); tobacco, pome fruit, vegetables, Thielaviopsis spp_ (black root rot) on soybean and cotton, such as T. basicola (synonym Chalara elegans); black stalk on scorpion Phytophthora (TiUetia SPP_) (* see smut or stinking smut), such as T. tritici on wheat (synonym τ. τ. caries) , wheat smut) and ta controversa (dwarf smut); Typhula incarnata (grey ferrets) on barley or wheat 'Urocystis Spp.), for example, on rye [ 149027.doc •182- 201103430 Helicobacter pylori (u. occulta) (stem Ear disease); Uromyces spp. (rust) on vegetables, such as beans (eg, u. appendiculatus, synonym for u phase〇H) And sugar beet (for example, u betae); Ustilago spp. (i〇〇se smut): in scorpion (such as smut) (U. nuda) and O. avaenae, corn (such as U. maydis _ · Maize smut) and sugar cane; Ventrica spp. Disease): Verticillium on apples (such as V. inaeq Uaiis) and pears; and various plants (such as fruits and ornamental plants, vines, soft fruits, vegetables, and field crops) Spp〇 (wild wilt), such as strawberry, canola, horse yam and tomato dahliae on the tomato. Compounds I, II and IV and combinations thereof are also suitable for controlling harmful fungi, respectively, in protecting stored products or harvests and protective materials. The term "protective material" is understood to mean the protection of the following technical and non-biological materials against the infestation and destruction of harmful microorganisms such as fungi and bacteria: such as adhesives, glues, wood, paper and cardboard, textiles, leather. , paint dispersions, plastics, cooling lubricants, fibers or fabrics. Regarding the protection of wood and other materials, special attention should be paid to the following harmful fungi: Ascomycetes, such as Ophiostoma spp., Ceratocystis spp., Aureobasidium pullulans, and stalks Sclerophoma spp., Chaetomium spp., Humicola spp., Petriella spp., Trichurus spp.; Basidiomycetes Such as, for example, Conophora 149027.doc •183-201103430 spp., Coriolus spp., Gl〇e〇phyllum spp. 'Lentinus Spp.), Pleurotus spp., Poria spp., Serpula spp., Tyromyces spp., Deuteromycete, such as genus Aspergillus SPP.), Helicobacter genus, Penicillium spp., Trichoderma spp., Alternaria, Paecilomyces spp., and zygomycetes, such as hair Muc〇r spp·' and in addition to protect stored products and harvests, care should be taken to Yeast fungi: Candida and Saccharomyces cerevisiae (Saccharomyces cerevisae) square Compounds I, II and IV, respectively, and combinations thereof may be used to improve the health of plants (Candida spp.). The present invention also relates to a method for improving the health of plants by treating plants, their propagation materials and/or the plants where they are grown or to be grown, in an effective amount of Compounds I, II and/or IV and combinations thereof, respectively. method. The term "phyto-health condition" is understood to mean the condition of a plant and/or its product, which is determined by several indicators, either alone or in combination with each other: such as yield (eg 'increased biomass and/or increased content of useful ingredients), Plant growth [eg, improved plant growth and/or greener leaves ("greening effect"), quality (eg, improved content or composition of certain ingredients) and resistance to abiotic and/or biological stresses Receptive. The indicators of the above identified plant health conditions may be interdependent or may be mutually causal. The compounds of formulae I, II and IV may exist in different crystalline variants which may differ in biological activity. It is also the subject matter of the invention. When treating fungi or plants by means of a fungicidal effective amount of active substance

[SI 149027.doc 201103430 When materials such as seeds, soils, tables, materials or rooms are protected from fungal attack, the compounds I, ^ and ... are used as they are or in the form of a composition. It can be applied before and after infection with plants, plant propagation materials such as seeds, soil, surfaces, materials or rooms. - The plant propagation material can be treated prophylactically with the compounds I, II and/or in the original form or with a composition comprising at least one compound I, π and/or 1 ¥ at or before the planting or transplanting. The invention also relates to agrochemical compositions comprising a solvent or solid carrier and at least one compound I, II and/or IV and for the use in the control of harmful fungi. The agrochemical composition comprises a fungicidally effective amount of the compound b^ and/or IV. The term "effective amount" means an amount of the composition or compound J, π and/or 1 of the compound I, II and / or IV which is sufficient to control harmful fungi or protective materials on cultivated plants and which does not substantially impair the treated plant. . The amount can vary within wide limits and depends on various factors such as the type of fungus being treated, the cultivated plant or material being treated, the climatic conditions, and the particular compound I used. Compounds I, II and IV and their salts can be converted into agrochemical groups of the customary type: 纟 ’ such as solutions, emulsions, suspensions, powders, powders, pastes, and ages. The type of composition will depend on the particular intended purpose; in each case, it will be ensured that the compounds of the invention are finely and uniformly distributed. The examples of the type of loquat are suspension (sc, 〇D, Fs), emulsifiable concentrate (4), emulsion (EW, E〇, ES), paste, tablet, wettable powder or powder (WP, SP, ss, ws, Dp, DS) or granules (GR, 149027.doc - 185. 201103430 FG, GG, MG), which may be water soluble or wettable, and used to treat plant propagation material (such as seeds) Gel (GF) Formulations The type of composition (eg, SC, OD, FS, EC, WG, SG, WP, SP, SS, WS, GF) is typically used after dilution. The type of composition (such as DP, DS, GR, FG, GG, and MG) is usually used without dilution. The composition is prepared in a known manner (see, US 3,060,084, EP-A 707 445 (Liquid Concentrate)' Browning: "Agglomeration", Chemical Engineering, 1 February 4, 147-48, Perry's Chemical Engineer's Handbook , 4th edition, McGraw-Hill, New York, 1963, pp. 8-57, following pages, w〇91/13546, US 4,172,714, US 4,144,050, US 3,920,442, US 5,180,587, US 5,232,701 ' US 5,208,030 'GB 2,095,558 ' US 3,299,566 &gt; Klingman: Weed Control as a Science (J. Wiley &amp; Sons, New York, 1961), Hance et al.: Weed Control Handbook (8th ed., Blackwell Scientific, Oxford, 1989) and

Mollet, H. and Grubemann, A.: Formulation technology (Wiley VCH Verlag, Weinheim, 2001)). Agrochemical compositions may also contain conventional adjuvants in agrochemical compositions. The auxiliaries used will depend on the particular application and the active substance. Examples of suitable auxiliaries are solvents, solid carrier 'dispersants or emulsifiers (such as 'other granules, protective colloids, surfactants and binders), organic and inorganic thickeners, bactericides, antifreeze Agents, defoamers, (if appropriate) colorants and tackifiers or binders (for example, for seed treatment formulations). [S3 149027.doc -186- 201103430: suitable, the solvent is water; organic solvent 'such as medium to high boiling mineral oil β knife such as kerosene or diesel; in addition to coal tar and oil of plant or animal origin, aliphatic, ring And aromatic smoke, such as toluene, xylene, stone butterfly, tetra-gasification, 7-based naphthalene or its derivatives; alcohols, such as methanol: B. #, propanol, butanol and cyclohexanol; diol Ketones such as cyclohexanone and • γ-butane vinegar; fatty acid dimethylamine, fatty acids and fatty acids and strong polar solvents such as amines such as N_f-pyrrolidone. The solid carrier is mineral soil, such as citrate, tannin, talc, kaolin, limestone, lime, white, red basalt, loess, clay, dolomite, alumina, calcium sulfate, magnesium sulfate, magnesium oxide; Grinding synthetic materials, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, urea; and plant-derived products such as glutinous meal, bark meal, wood meal and nut meal, cellulose powder; and other solids Carrier. Suitable surfactants (adjuvants, wetting agents, tackifiers, dispersants or emulsifiers) are aromatic sulfonic acids (eg lignin sulfonic acid (B〇rresperse® type, Borregard, Norway), phenolsulfonic acid, naphthalene Sulfonic acid (M〇rwet® type, Akz〇Nobel, USA), dibutylnaphthalenesulfonic acid (Nekal® type, basf, Germany)) and alkali metal salts, alkaline earth metal salts and ammonium salts of fatty acids; alkane-sulfonate Acid salt, alkyl aryl sulfonate, alkyl sulfate, lauryl ether sulfuric acid salt, 爿 肪 肪 alcohol sulfate, and sulfated hexadecanol, heptadecyl alcohol and stearyl alcohol, Sulfated fatty alcohol glycol ether, in addition to condensate of naphthalene or naphthalene acid with phenol and formaldehyde, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkane Phenyl phenyl polyglycol ether, tributyl phenyl polyglycol ether, distearyl phenyl PEG, aryl aryl group 149027.doc -187- 201103430 ether alcohol, alcohol and Fatty alcohol/ethylene oxide condensate, ethoxylated castor oil 'polyoxyethylene yard ether, ethoxylated polyoxypropylene, lauryl polyethylene glycol ether, sorbate Sugar alcohol esters, lignin sulfite waste liquids and proteins, denatured proteins, multi-flavored (eg 'mercapto cellulose'), hydrophobic modified starch, polyethylene glycol (Mowiol® type, ciariant, Switzerland), poly slow Examples of acid esters (Sokolan® type 'BASF, Germany), polyalkoxylates, polyvinylamines (Lupasol type 'BASF, Germany), polyvinylpyrrolidone and copolymers thereof 0 (ie, A compound that imparts improved fluidity to the composition', ie high viscosity under static conditions and low viscosity during oscillation

Degree) for polysaccharides and organic and inorganic clays such as Sanzan Gum (Kelzan®, CP)

Kelco, U.S.A.) ^ Rhodopol® 23 (Rhodia, France) ^ Veegum® (R.T. Vanderbilt, U.S.A.)^ Attaclay® (Engelhard Corp., NJ, USA) 〇

A bactericide may be added to preserve the composition and stabilize the composition. Examples of suitable rights are those based on double gas and phenyl decyl hemiformic acid (ICI's Proxel® or Thor Chemie's Acticide® RS and Rohm &amp; Haas

Kathon® MK) is a bactericide and an isothiazolinone derivative such as an alkyl isocyanide. Sitting on lin and benzoisothiazolone (Thutr chemie Acticide® MBS). Examples of suitable antifreeze agents are ethylene glycol, propylene glycol, urea and glycerin. Examples of antifoaming agents are polyoxynitride emulsions (such as Siiikon® SRE, Wacker, Germany or Rhodorsil®, Rh〇dia, France), long chain alcohols, fatty acids, fatty acid salts, fluoroorganic compounds, and mixtures thereof. t I49027.doc •188- 201103430 A The two colorants are low water-soluble pigments and water-soluble dyes. Mentioned and _ red 1, pigment blue 15:4, pigment blue 15:3, pigment blue 15:2, pigment blue 15], pigment blue 8G, pigment yellow i, pigment yellow 13, pigment red (1), pigment red 2, pigment red 48: 1, pigment red ..., pigment red plus, pigment dial 43, pigment orange 34, pigment orange 5, pigment green % 'pigment green 7, pigment white 6, pigment brown 25, alkaline purple 10, alkali Sexual purple 49, acid red $ 丨, acid red 52, acid red 14, acid blue 9, acid yellow 23, alkaline red 1 〇, alkaline red 108. Examples of 匕 tackifiers or binders are polyethylene phase, polyethylene acetate, polyvinyl alcohol and cellulose ether (Tyl〇se®, SMnEtsu, Scratch). Powders, dispersion materials and powders can be prepared by mixing the compound I and, if appropriate, other active substances with at least one solid carrier or with grinding. Granules can be prepared by binding the active material to a solid carrier, for example, coated granules, impregnated granules, and homogeneous granules. Examples of solid carriers are mineral soils such as tannin, silicate, talc, kaolin, activated clay, limestone, lime, chalk, red basalt, loess, clay, dolomite, sulphate, magnesium sulfate , oxidized town; ground synthetic materials, fertilizers, such as sulphate, phosphoric acid, nitric acid, urea, and plant-derived products, such as cereal meal, bark meal, wood meal and nut meal, cellulose Powder; and other solid carriers. Examples of composition types are: 1. Type of composition diluted with water 0 Water soluble concentrate (SL, LS) 149027. doc - 189 - 201103430 The amount of the compound of the invention is ι 〇! Dissolved in 9 parts by weight of water or a water-soluble solvent. Or I, add a wetting agent or other additives. Once diluted with water, the active substance dissolves. In this way, a composition having an active substance content of 1 G% by weight was obtained. Ii) Dispersible Concentrate (DC) 20 parts by weight of the compound j of the present invention is dissolved in 7 parts by weight of cyclohexanone, while adding 10 weights of a chemical agent such as polyethylene. ratio. Each alpha ketone. Dilute with water to produce a dispersion. The active substance content was 20% by weight. Iii) Emulsifiable Concentrate (EC) 15 parts by weight of the compound I of the present invention is dissolved in 75 parts by weight of xylene, and simultaneously added calcium dodecylbenzenesulfonate and eucalyptus ethoxylate (5 parts by weight, respectively) . Dilute with water to produce an emulsion. The composition has an active substance content of 5% by weight. Iv) Emulsion (EW, EO, ES) 25 parts by weight of the compound I of the invention is dissolved in 35 parts by weight of xylene, together with calcium dodecylbenzenesulfonate and castor oil ethoxylate (5 parts by weight, respectively) . This mixture was introduced into 30 parts by weight of water by means of an emulsifier (Ultraturrax) and made into a homogeneous emulsion. Dilute with water to produce an emulsion. The composition has an active substance content of 25% by weight. v) Suspensions (SC, OD, FS) In the agitated ball mill '20 parts by weight of the compound I of the invention, while adding 10 parts by weight of dispersant and wetting agent and 70 parts by weight of water or organic solvent' to obtain fine Active substance suspension. Dilution with water produces a stable suspension of the active substance. The active substance content in the composition was 20% by weight.

[SI 149027.doc -190- 201103430 vi) Water-dispersible granules and water-soluble granules (Wg, sg) 50 parts by weight of the compound i of the present invention is finely ground, and 5 parts by weight of a monthly effluent and a wetting agent are added. It is prepared as a moisture-retaining or water-soluble granule by means of industrial grade equipment such as extruders, spray towers, fluidized beds. Dilution with water produces a stable dispersion or solution of the active substance. The composition has an active substance content of 50% by weight. Vii) Water-based powder and water-soluble powder (wp, sp, SS, WS) 75 parts by weight of the compound of the invention were ground in a rotor stator mill while 25 parts by weight of a dispersing agent, a wetting agent and a silicone rubber were added. Dilution with water produces a stable dispersion or solution of the active substance. The active substance content in the composition was 75 wt%. Viii) Gel (GF) In an agitated ball mill, 20 parts by weight of a compound of the invention is milled while adding 10 parts by weight of a dispersant, i by weight of a gelling agent wetting agent, and 7 parts by weight of water or an organic solvent. A fine suspension of the active substance is obtained. A stable suspension of the active substance is produced by dilution to obtain a composition having 2% by weight (w/w) of the active substance. 2. Type of composition to be applied without dilution ix) Powderable powder (DP, DS) 5 parts by weight of the compound of the present invention was finely ground and intimately mixed with 95 parts by weight of fine powdery kaolin. This operation gave a pulverizable composition having an active substance content of 5% by weight. X) Granules (GR, FG, GG, MG) 5 parts by weight of the compound of the invention were finely ground and combined with 99 parts by weight of the vehicle group 149027.doc 191 - 201103430. Current methods are extrusion, spray drying or fluidized beds. This operation was obtained with 0.5 weight. /. A granule that is applied without dilution of the active substance content. Xi) ULV solution (UL) 10 parts by weight of the compound of the present invention is dissolved in 9 parts by weight of an organic solvent such as xylene. This operation resulted in an undiluted composition having an active substance content of 1% by weight. The agrochemical composition typically comprises between 0.51 and 95% by weight, preferably between 0.5 and 重量 by weight, of an optimum of between 0.5 and 9% by weight. An active material having a purity of 90% to 1%, preferably 95% to 丨〇〇% (according to the nmr spectrum) is used. For the purpose of treating plant propagation materials (especially seeds), water-soluble concentrates (LS), flowable concentrates (FS), powders for drying treatment (DS), water-dispersible powders (ws) for (iv) treatment are usually used. , water-soluble powder (ss), emulsion (ES), emulsifiable concentrate (EC) and gel. These compositions can be applied to plant propagation materials either diluted or undiluted, especially in seed-related compositions at 2 to 1 〇 After the double dilution, an active substance concentration of from 1 to 60, preferably 〇u4% by weight, is obtained in the ready-to-use preparation. It can be applied before or during sowing. Methods of applying agrochemical compounds and compositions thereof to or treating plant propagation materials, particularly seeds, are known in the art, including propellant materials (dressi♦ coating, pelleting, soaking, and ditching). In a preferred embodiment, the compound or composition thereof is separately applied to the plant propagation material by a method that does not induce germination, such as by seed medicine, pelleting, coating, and spreading. - a preferred embodiment of the 'suspension type (FS) composition for seed

[SI 149027.doc -192- 201103430 g / Ι active substance, 1-200 〇 to 400 g / Ι binder, 〇 treatment. Typically the 'FS composition may comprise l_8〇〇g/ι surfactant, 〇 to 200 g/ι antifreeze, up to 200 g/Ι pigment, and to liters of solvent (preferably the water active substance may be as it is or a form of the composition, for example, in the form of a direct sprayable solution, (iv), a suspension, a dispersion, an emulsion, an oil dispersion, a paste, a powderable product, a dispersed material or granules, by spraying 'atomization, Powdering, spreading, brushing, dipping or pouring. The application form is entirely dependent on the intended purpose; it is intended to ensure the finest possible distribution of the active substance of the invention in each case. It may be by emulsion concentrate, paste or Wettable powder (sprayable powder, oil dispersion) is added with water to prepare an aqueous application form. To prepare an emulsion, paste or oil dispersion, it can be made by a wetting agent, a viscous agent, a dispersing agent or an emulsifier. Or a substance dissolved in an oil or a solvent is homogenized in water. Alternatively, a concentrate composed of an active substance, a wetting agent, a tackifier, a dispersing agent or an emulsifier and, if appropriate, a solvent or oil may be prepared, and such Concentrate suitable for Diluted with water. The concentration of the active substance in the ready-to-use preparation can vary over a wide range. Generally, the concentration ranges from 0.0001 to 1% by weight, preferably from 0.001 to 9% by weight of active substance. The method (ULV) successfully uses the active substance, it is possible to apply a composition comprising more than 95% by weight of active substance, or even to apply the active substance without additives. When used for plant protection, depending on the type of action desired The amount of active substance applied is 0.001 to 2 kg / part (kg / ha) 'better 0.005 to 2 public I49027.doc -193- 201103430 kg / public 'better 0.05 to 0.9 kg / public , especially 75 n75 kg / public. When treating plant propagation materials (such as seeds) by spraying, coating or soaking seeds, for example, the active mass generally needs to be in the following range: ϋ to 1000 grams, preferably 1 Up to 1000 grams, more preferably 1 to 100 grams and most preferably 5 to 1 gram per 100 kilograms of plant propagation material (preferably seeds). When used to protect materials or store products, the quality of the applied active depends on the application. Domain type Depending on the desired action, the amount conventionally used for material protection is, for example, from 0.001 to 2 kg, preferably from 5 to 8,000 kg of active substance per cubic meter of treated material. Wetting agents, adjuvants, herbicides, bactericides, other fungicides and/or insecticides are added to the active substance or compositions containing it' (if appropriate) until it is ready for use (in-tank mixing) These agents may be mixed with the composition of the invention in a weight ratio of 1:1 Torr to 1 〇〇 1, preferably 1: 10 to 10: 1. The adjuvants which may be used are especially modified organic polyliths. Oxygen hospital, such as u S 240, alcohol alkoxylate, such as 16,

MBA 1303, Plurafac lf 300® and Lutensol ON 30®; EO/PO back-end polymer 'for example, 'additional ^ and (6) (four) alcohol ethoxylates, such as Lutensol xp 8〇16; and: octyl stellite Sodium ate 'such as Leophen RA®. The compositions of the present invention in the form of fungicides may also be provided together with other active substances, such as herbicides, insecticides, growth regulators, fungicides or fertilizers, as premixes or, if appropriate, until ready for use.

[SI 149027.doc -194- 201103430 Only mixed (in-tank mixing). Mixing Compounds I, II and/or IV in the form of a fungicide or a composition comprising the same with other fungicides results in a number of situations: the fungicidal spectrum of activity is expanded or prevented. Resistance development. In addition, in many cases, synergies are obtained. The following list of actives that can be used in combination with the compounds of the present invention is intended to illustrate possible combinations, but is not intended to be limiting: A) str〇bilurin, azoxystrobin, and delixillamide ( Dimoxystr〇bin), enestroburin, fiuoxastr〇bin 'kresoxim-methyl, methotrexate, oryrobacter (orysastrobin), "&gt; acCOXyStr〇bin, pyracostrobin, pyrier: ncarb" trifloxystrobin, 2-(2-(6-( 3-Chloro-2-indolyl-phenoxy)-5-fluoro-pyrimidin-4-yloxy)-phenyl)_2-decyloxyimidoindolyl-acetamide, 3-methoxy 2-(N-(N-(4-decyloxy-phenyl)-cyclopropane-carboxamidothio-indenyl)-phenyl)-decyl acrylate, (2-gas-5-[ 1-(3-Mercaptobenzyloxyimino)ethyl]benzyl)amino decanoate and 2-(2-(3-(2,6-diphenyl)-1-methyl) -Allallylaminooxyindolyl)-styl)_2-decyloxyimido-N-indenyl-acetamide; B) Carboxylammonium - Carboxyanilide : Benalaxyl, Benalaxyl-M, benodanil, bixafen, boscalid, carb〇xin, methylfuran Amine 149027.doc -195·201103430 (fenfuram), fenhexamid, flutolanil, furametpyr, isoform. Isopyrazam, isotianil, kiralaxyl, mepronil, metalaxyl, methaul-M (mefenoxam), 0 Ofurace, oxadixyl, ox; yCarb〇xin, penthiopyrad, sedaxane, tecloftalam, race Thifluzamide, tiadinil, 2·amino-4-mercapto-thiazole-5-nonanilide, 2-gas-N-(1,1,3-tridecyl-indan 4-yl)-nicotine decylamine, N-(3,,4',5,-trifluorobiphenyl-2-yl)-3-difluoroindol-1-yl-1H-pyrazole- 4-decylamine, Ν-Ο1-trifluoromethylthiobiphenyl-2-yl)-3-difluoromethyl-1-indenyl-1H-&quot; Biazole-4-decylamine, N -(2-(l,3-dimercapto-butyl)-phenyl)-1,3-didecyl-5-fluoro-1H-pyrazole-4-decylamine and N-(2-( l,3,3-Trimethyl-butyl)-phenyl)-1,3-dimercapto-5-fluoro-1H-dbiazole-4-carboxamide; - Rebelism: Dimethomorph, flumorph, Ding. Pyrimorph; - benzoic acid amine: It flumetover, fluopicolide, fluopyram, zoxamide, N-( 3-ethyl-3,5,5-trimethyl-cyclohexyl)-3-mercaptoamino-2-hydroxy-benzoguanamine; - other apoemic amines: carpropamid, hundred Dicyclomet, mandiproamid, oxytetracyclin, silthiofarm and N-(6-methoxy-

[SI 149027.doc -196· 201103430 pyridin-3-yl)cyclopropanecarboxylic acid decylamine; C) ° sitting class - three 0 sitting class: Azacon 0 sitting (azaconazole), than donut (bitertanol), brom ° bromuconazole, cyproconazole, difenoconazole, dichoxon, diniconazole, dioxin, ketone, epoxiconazole, fenbux芬buconazole, fluoroquine. Fluquinconazole, flusilazole, flutriafol, hexaconazole, imine. Ibibenconazole, ipconazole, metconazole, myclobutanil, oxpoconazole, paclobutrazole, penconazole , propiconazole, prothioconazole, and stone scorpion. Simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, 1-(4- Chloro-phenyl)-2-([1,2,4]triin-1-yl)-cycloheptanol; - taste ° sitting class: cyazofamid, imazalil, rice mark Peacheazoate, prochloraz 'triflumizole'; - benzimidazoles: benomyl, carbendazim, fuberidazole, ° benzophene (thiabendazole); 149027.doc -197- 201103430 ~ Others: ethaboxam, etridiazole, hymexazole and 2-(4-gas-phenyl)-N -[4-(3,4-Dimethoxy-phenyl)-isoxazol-5-yl]-2-prop-2-ynyloxy-acetamide; D) Heterocyclic compound-. Specific biting: fluazinam, pyrifenox, 3-[5-(4-gas-phenyl)-2,3-dimethyl-isoxazodin-3-yl] Bisidine, 3-[5-(4-indolyl-phenyl)-2,3-dimercapto-isoxazodin-3-yl]pyridinium, 2,3,5,6-tetra-gas- 4-sulfonyl-based. Bisidine, 3,4,5-tripyridine, 2,6-di-carbonitrile, N-(l-(5-bromo-3-a-pyridin-2-yl)-ethyl)-2,4 - Dichloronicotinium amide, N-[(5-bromo-3-chloro-pyridin-2-yl)-methyl]-2,4-diqi-nicotinium amide; D D class: performance. Bupirimate, cyprodinil, diflumetorim, fenarimol, ferimzone, mepanipyrim, gas Nitrapyrin), I benzene. Niarim〇l, pyrimethanil; - dispatching class: triforine; -° ratio B: seed dressing 17 (fenpiclonil), defensive ning (fludioxonil) • 琳琳类: adimorph (aldimorph), morphine (dodemorph), acetaminophen, fenpropimorph 'tridemorph'; - 派 ° class: benzene ore (fenpropidin); - dimethylimine: fluoroimid, iprodione, procymi done, konken [S1 149027.doc -198- 201103430 (vinclozolin); Non-aromatic 5-pentene heterocycle: „恶. fainoxad〇ne, quinamidone, fiutianii, octhilinone, acesulfame (pr〇benazole), 5-amino-2-isopropyl-3-oxooxy-4-o-tolyl-2,3-dihydro-pyrazole-1-thiocarboxylic acid S-sodium propyl S Purpose, - Others: acidified benzothiadiazole-S-decyl ester (acibenzolar_s_methyl), alpha azulbrom, azilzin, blasticidin-S, Captafol, captan "chinomethionat", "dazomet", "debacarb", diclomezine, difenzoquat, benzoic acid-sulfonate, fenoxanil, Folpet, 〇x〇linic acid, piperalin, proquinazid, pyroquilon, quinoxyfen, imidazolium Triazoxide), tricyclazole '2-butoxy-6-iodo-3-propyl benzo-4-one, 5-chloro-1-(4,6-dimethoxy-pyrimidine) 2-yl)-2-mercapto-1H-benzimidazole, 5-gas-7-(4-mercaptopiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-[ 1,2,4]triazolo[1,5-&amp;]pyrimidine and 5-ethyl-6-octyl-[1,2,4]triazolo[l,5-a]pyrimidin-7- Base amine; E) urethane-thiocarbamate and dithioamino phthalate, ferbate, mancozeb, maneb, wei 149027.doc -199- 201103430 Metha, methasulphocarb, metiram, pr0pineb, thiram, zineb, thiram ( Zirarn); - Amino citrate: benthiavalicarb, diethofencarb, iprovalicarb, propamocarb, chlorfenapyr hydrochloride, vaiiphenal And N-(l-(l-(4-cyano-phenyl)ethanesulfonyl)-butan-2-yl)amino decanoic acid _ (4-fluorophenyl) ester; F) other active substances - Anthraquinones: sputum, dodine, tannin free test, guazatine, bismuth octanoic acid acetate, iminoctadine, gram heat triacetate, gram heat (alkylbenzene sulfonic acid) Salt); - Antibiotics: kasugamycin, kasugamycin hydrochloride, streptomycin, polyoxine, validamycin A; - nitrophenyl Derivatives: binapacryl, dinobuton, dinocap, sputum ester 〇1 such as 1^1-isopropyl, tetrakis nitrobenzene (tecnazen); organometallic compounds: three Fentin salts, such as triphenyltin sulphate, triphenyltin or fentin hydroxide; - sulfur-containing heterocyclic compounds: dithianon, rice stalk (isoprothiolane); - Institutional compounds: edifenphos, triethylphosphonic acid (fosetyl), triethylphosphonic acid (fosetyl-aluminum), propyl joy [S3 149027.doc -200- 201103430 pine (iprobenfos ), phosphorous acid and its salts, white pine (pyraz〇ph〇〇, tolclofos-methyl; - organochlorine compounds: chlorothalonil, dichlofluanid, dichlorophen ), I sulfsulfamide, hexa-benzene, penced culron, pentachlorocyl and its salts, phthalide, quintozene, thiophanate-methyl, Tolylfluanid, N-(4-Gas-2-nitro-phenyl)-N-ethyl-4-mercapto-benzenesulfonamide; - Inorganic active substance: Bordeaux mixture , copper acetate, copper hydroxide, copper oxide, basic copper sulfate, sulfur; - other · biphenyl, bronopol, cyflufenamid, cymoxanil, diphenylamine , metrafenone, mildiomycin 'oxin-copper' Prohexadione-calcium, spiroxamine, tolylfluanid, N-(cyclopropylmethoxyimino)-(6-difluoro-decyloxy-2, 3-difluoro-phenyl)-indenyl)-2-phenylethylamine, N1-(4-(4·-gas-3-tris-methoxy-phenoxy)-2,5-diindole Base-stylethyl-N-methylformamidine, Ν-(4-(4-fluoro-3-trifluoromethyl-phenoxy)_2,5-dimethyl-phenyl)-indole- Ethyl-hydrazine-methylformamidine: ΝΓ-(2-methyl-5-trifluoromethyl-4-(3·tridecylfluorenyl-propoxy)-phenyl)-fluorene-ethyl -Ν-methylformamidine, Ν·-(5-difluoromethyl-2-indolyl-4-(3-trimethyldecyl-propoxy)-phenyl)-indole-ethyl-hydrazine -methyl hydrazine, 2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetamidine 149027.doc -201 - 201103430 yl]-piperidine- 4-yl}-thiazole-4-decanoate-(1,2,3,4-tetrahydro-naphthalene-fluorenyl)-decylamine, 2-{1-[2-(5-methyl- 3-trifluoromethyl-pyrazol-1-yl)·ethinyl]-piperidin-4-yl}-thiazole-4-furoic acid methyl-(R)-l,2,3,4-tetra Hydrogen_naphthalen-1-yl-decylamine, acetic acid 6-t-butyl-8-fluoro-2,3-dimercaptoquinoline-4-yl ester and decyloxy-acetic acid 6-t-butyl - 8-Fluoro-2,3-dimercapto-indololin-4-yl ester. G) growth regulators abscisic acid, amidochlor, ancymidol, 6-benzylamine hydrazine, brassinolide, butralin, gramme (chlormequat) (chlormequat chloride), choline chloride, cyclanilide, diced, daminozide, dikegulac, ° plug Dimethipin, 2,6-dimercapto ratio bite, ethephon flumetralin, flurprimidol, fluthiacet, chlorpyrifos (forchlorfenuron) ), gibberellic acid, inabenfide, indole-3-acetic acid, maleic hydrazide, mefluidide, mepiquat (strong cotton chloride), naphthaleneacetic acid, N-6-benzyl adenine, bucksin, cyclamate (calcium cyclate), propyl jasmonate (prohydrojasmon), ° thidiazuron, Triapenthenol, tributyltrithiophosphate, 2,3,5-triiodobenzoic acid, trinexapac-ethyl and dilute °Sit; [S1 149027.doc -202- 201103430 Η) Herbicide - Acetone: acetochlor, alachlor, butachlor, dimethachlor, Dimethenamid, flufenacet, mefenacet, metolachlor, metazachlor, naphthylamine (napropamide), naproanilide, pethoxamid, pretilachlor, propachlor, thenylchlor; - amino acid derivatives: bilapia Bilanafos), glyphosate, glufosinate, sulfosate; - aryloxyphenoxypropionates: clodinafop, cyhalofop-butyl ), ° 恶 ° sitting on the grass fenoxaprop (fenoxaprop), mouth than fluazifop (fluazifop), ° than haloxyfop (haloxyfop). Metaamifop, propaquizafop, quizalofop, quizalofop-P-tefuryl; - ratio of 11 to 11: diquat (diquat) ), paraquat; -(thio)amino phthalate: asulam, butarate, carbeamide, desmedipham, peltani (dimepiperate), eptam (EPTC), esprocarb, molinate, orbencarb, phenmedipham, prosulfocarb, valerian 149027.doc -203 - 201103430 (pyributicarb), thiobencarb, triallate; - cycloheximide: butroxydim, clethodim, ringworm Cycloxydim), profoxydim, sethoxydim, tepraloxydim, tralkoxydim; - dibasic aniline · benfluralin, ethylene butene Ethalfluralin, oryzalin, pendimethalin, prodiamine, trifluralin Ifluralin); - Diphenyl mystery: acifluorfen, aclifen, bifenox, diclofop, ethoxyfen, flunarizine Fomesafen, lactofen, oxyfluorfen; - benzoquinones: bomoxynil, dichlobenil, terpene ; - 咪 ° sitin ketone · · p rice vinegar (imazamethabenz), imazamox (imazamox), azomic acid (imazapic), imazapyr (imazapyr), imazaquin (imazaquin) ,. Imazethapyr; - phenoxyacetic acid: clomeprop, 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4-DB, dichlorprop , MCPA, MCPA-thioethyl, MCPB, 2-曱-4-chloropropionic acid (Mecoprop); -° ratio: chloridazon, flufenpyr-ethyl, °乙草斯的(fluthiacet), 禾草敏

E SI 149027.doc -204- 201103430 (norflurazon), pyridate (pyridate); Compared with D: chloramine ° than amino acid (aminopyralid), clopyralid (clopyralid). Diflufenican, dithiopyr 'It °Hurclone, It's fluroxypyr, picloram, picolinafen, ° Straw (thiazopyr); - scutellaria urea: ami 密 密 续 ( ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami Ethyl), chlorsulfuron, cinosulfuron, cyclosu+lfamuron, ethoxysulfuron, flazasulfuron, vent Flvicetosulfuron, fluorine_flupyrsulfuron, foramsulfuron, halosulfuron, halosulfuron, imazosulfuron Iotosulfuron, mesosulfuron, metsulfuron-methyl, nicosulfuron, oxasulfuron, fluorine Primisulfuron, fluorite yellow, prosulfuron, D Pyrazosulfuron, rimsulfuron, sulfometuron, sulfosulfuron, thifensulfuron, triasulfuron, Tribenuron, trifloxysulfuron, triflusulfuron, tritosulfuron, 1-((2-chloro-6-propyl-mi). And [l,2-b]pyridazin-3-yl)sulfonyl)-3-(4,6-dimethoxy-pyrimidin-2-yl)urea; 149027.doc -205 - 201103430 - III Calling class: ametryn, atrazine, cyanazine, dimethametryn, thiazinine, (ethiozin), hexazinone, stupid 0 Immamitron, metribuzin, prometryn, simazine, terbuthylazine, terbutryn, triaziflam ) - Urea: chlorotoluron, daimuron, diuron, fluometuron, isoproturon, linuron Toluene D-sialon (methabenzthiazuron), tebuthiuron; - other acetamidine lactate synthase inhibitor: bispyribac-sodium 曱 气 气 clo clo clo clo clo clo clo ), diclosulam, florasulam, flucarbazone, flumetsulam, metosulam, benzylamine tank Ortho-sulfamuron, penoxsulam, propoxycarbazone, pyribambenz-propyl, pyribenzoxim, pyrifalid , pyridylbac-methyl, pyrimisulfan, pyrithiobac, pyroxasulfone, pyroxsulam; - other: amine °圭草_ _ (amicarbazone), amine-based three-degree sitting, anthonyfoss (anilofos), flubendiamide (beflubutamid), herbicide vinegar

[SI 149027.doc -206- 201103430 (benazolin), bencarbazone, benfluresate, benfluresate. More than benzofenap, bentazone, benzobi.cyclon, bromacil, bromo mobutide, aerobic. Butafenacil, butamifos, cafenstrole, carfentrazone, cinidon-ethlyl, enemies (chl〇rthal) ), cinmethylin, clomazone, cumyluron, cyprosulfaniide, dicamba, difenzoquat, difluoro. Diflufenzopyr, Drechslera monoceras, endothal, ethofumesate, etobenzanid, IV. Sitting on fentrazamide, flumiclorac-pentyl, flumioxazin, flupoxam, flurochloridone. Flurtamone, indanofan, and different. Isoxaben, heterosexual. Isoxaflutole, lenacil, propanil, propyzamide, quinclorac, quinmerac, methyl oxaloacetone Mesotrione), mercaptoic acid, naptalam, acetylene beta oxadiargyl, oxadiazon, oxazic丨omefone, cyclopentazone With (pentoxazone), a sitpox (pinoxaden), bisoxaquinonitrile (卩7^〇1〇1^1), ethyl ° 草 草 ether (卩}^3£11^611-6) ^1), ° than continued Toli 149027.doc -207- 201103430 (pyrasulfotole), grass. Pyrazoxyfen, pyrazoonate, quinoclamine, saflufenacil, sulcotrione, sulfentrazone, special grass Terbacil, tefuryltrione, tembotrione, thiencarbazone, topramezone, 4-^. -3- [2-(2 -methoxy-ethoxymethyl)-6-trifluoromethyl-n-pyridyl-3-carbonyl]-bicyclo[3.2.1]oct-3-en-2-one, (3-[2- Gas 4-fluoro-5-(3-methyl-2,6-di-oxo-4-trifluoromethyl-3,6-dihydro-2H-pyrimidin-1-yl)-phenoxy]- Pyridin-2-yloxy)-ethyl acetate, 6-amino-5-chloro-2-cyclopropyl-pyrimidine-4-carboxylic acid methyl ester, 6-chloro-3-(2-cyclopropyl-6 -mercapto-phenoxy)-pyridazin-4-ol, 4-amino-3-gas-6-(4-chloro-phenyl)-5-fluoro-pyridine-2-decanoic acid, 4-amine Base-3-gas-6-(4- gas-2-say-3-methoxy-phenyl)-«·比〇定_2~ methyl formate and 4-amino-3-gas-6- (4-Gas-3-didecylamino-2-fluoro-phenyl)-pyridine-2-decanoate. I) Insecticides - Organic (thio) salts: acephate, azamethiphos, azinphos-methyl, chlorpyrifos , chlorpyrifos-methyl, chlorfenvinphos, two. Diazinon, dichlorvos, dicrotophos, dimethoate, disulfoton, ethion, fenitrothion, fenthion ), isoxathion, malathion, damasson [S] 149027.doc •208 - 201103430 (methamidophos), methadinion, methyl-parathion, meson pine Mevinphos), monocrotophos, oxydemeton-methyl, paraoxon, parathion, phenthoate, phosalone, benefit Phosmet, phosphamidon, phorate, phoxim 'pirimiphos-methyl, profenofos prothiofos, killer ( Sulprophos), tetrachlorvinphos, terbufos, triazophos, trichlorfon; - urethanes: alanycarb, aldicarb , bendicarb (bendiocarb), free gram (benfuracar b), carbaryl, carbofuran, carbosulfan, fenoxycarb, furathiocarb, meticarb, nanet ( Methomyl) 'oxamyl, anti-pirimicarb, propoxur, thiodicarb, triazamate; - pyrethroid: pyrethrum (allethrin) ), bifenthrin, cyfluthrin, cyhalothrin, cyPhenothrin, cypermethrin, α-赛灭宁, β_赛灭宁, ζ_赛Zeta-cypermethrin, deltamethrin, esfenvalerate, etofenProx, fenpenin 149027.doc • 209- 201103430 (fenpropathrin), fenvalerate, fen Imiprothrin, iarnbda-cyhalothrin, permethrin, pranethrin, pyrethrin I and II, resrnethrin, gas Silafluofen, tau_fiuvalinate, and tefluthr In), tetramethrin, trolomethrin, transfiuthrin, pro-IL-profluthrin, dimefluthrin; - insect growth regulator: a) Chitin synthesis inhibitors: benzoylureas. Chi〇rfiuazuron, cyramazin, diflubenzuron, flucycloxuron, Dunferon ( Nufen〇xur〇n), hexaflumuron, lufenuron, novaluron, teflubenzuron, triflumuron, buprofezin, stupid Insect test (diofenolan), hexythiazox, etoxazole, ei〇fentazjne; b) ecdysone retinoic acid agent. haofofozide, methoxyfenozide ), tebufen〇zide, azadirachtin; c) juvenile hormone analogues: pyriproxyfen, meth〇prene, fenolect; Synthetic inhibitors. Spir〇diclofen, spiromesifen 'spiders B g(Spir〇tetramat); - nicotinic receptor agonist/antagonist compound: cotinine 149027.doc •210· 201103430 (clothianidin), 11 dinotefuran, imidacloprid , thiamethoxam, nitenpyram, acetamiprid, thiacloprid, 1-(2-gas-pyrene-5-yl fluorenyl) -2 - schlossylidene _ 3,5-dimethyl-[1,3,5]triazine; -GABA inhibitor compound: endosulfan, ethiprole, fenapini (fipronil), vaniliprole, pyrafluprole, pyriprole, 5-amino-l-(2,6-dioxa-4-methyl-phenyl)-4 - Amines - 1 - 比 - ° than salivation - 3 - thioglycolate; - Macrolides: aba, ab (abamectin), emmeectin (ememectin), metostatin (milbemectin), lepimectin, spinosad, spinetoram; - mitochondrial electron transport inhibitor (METI) I acaricide: fenazaquin (pyridaben), defenfen (tebufenpyrad), off Tolfenpyrad, flufenerim; -METI II and III compounds: acequinocyl, fluacyprim, hydramethylnon; - uncoupling agent: worm Nitroxide (chlorfenapyr); - oxidative acidification inhibitors: cyhexatin, diafenthiuron, 'fenbutatin oxide, propargite; 149027.doc -211 · 201103430 - Clay rupture agent compound: cryomazine; - mixed functional oxidase inhibitor: piperonyl butoxide; - sodium channel blocker: indoxacarb, metaflumizone; - Others: Benclothiaz, bifenazate, cartap, flonicamid, pyridalyl, pymetrozine, sulfur, Thiocyclam, flubendiamide, chlorantraniliprole, chlorinated receptor inhibitor (cyazypyr, HGW86), cyenopyrafen, ° sulphur Flupyrazofos, cyflumetofe n), amidoxime (amidoflumet), imicyafos, imipenem (1^1; 1^1111*〇11) and °pyrfluquinazon. The invention further relates to an agrochemical composition comprising at least one compound I, II and/or IV (component 1) and at least one other active substance suitable for plant protection (for example selected from group A) to 1) (Component 2), especially another fungicide, such as one or more fungicides from groups A) to F) as described above, and, if desired, a suitable solvent or mixture of solid carriers. Particular attention is paid to their mixtures' because at the same application rate, many of them exhibit a higher efficacy against harmful fungi. Furthermore, a mixture of compounds I, π and/or IV and at least one fungicide from group VIII) to cockroaches as described above against harmful fungi than individual compounds j, π or 1 ¥ or from group Α to F Individual fungicides are more effective against their fungi. By applying the compound 149027.doc •212-201103430 1, π and/or IV together with at least one active substance from the group ... to ^, a synergistic ration can be obtained, that is, a simple phase obtained not only by individual effects Add (collaboration mixture). According to the invention, the administration of the compounds I, II and/or IV together with at least one further active substance is understood to mean that at least one compound of the formula and/or ... and at least one further active substance are present simultaneously in a fungicidal effective amount. Point (ie, 'a harmful fungus that is controlled or its habitat, such as infected plants, % of materials (especially seeds), surfaces, materials or soil damage, and plants, plant propagation materials that are protected from fungal attack (especially Seed), bandits, surfaces, materials or rooms). This can be done by simultaneously (in combination (for example in the form of a mixed formulation in the tank) or separately) or by the continuous application of the compound [, π &amp; /4ΐν and to the other active substance, the time interval between the individual applications in # The choice is made to ensure that the active substance applied first occurs at a point of action in a sufficient amount when the other active substance is applied. The order of administration is not critical to the practice of the invention. In a mixture of the invention (ie, a composition of the invention comprising a compound [, hydrazine or hydrazine (component 1) and another active substance (component 2) (eg, active material from group VIII (4))) 'The weight ratio of the group to the component 2 - generally depends on the nature of the active substance used, usually in the range of 1:100 to 100:1, often in the range of 1.50 to 50:1, preferably It is more preferably in the range of 1:10 to 10:1 and especially in the range of ^ to 在 in the range of 1:2 〇 to 2 〇:1. In a ternary mixture (ie, comprising one compound (component 1} and the first other active material (component 2) and a second other active material (component 3) (eg, from group A) to I) In the active substance) composition of the invention, the weight ratio of component 1 to group 149027.doc -213·201103430 part 2 depends on the nature of the active substance used, preferably in the range of 1:5 〇 to 50:1. Within the range of 1:10 to 10:1, and the weight of component 1 and component 3 is preferably in the range of 1:5〇 to 5〇:1 and especially in the range of 1:1〇 to 10: Within the scope of 1. The components such as 5H can be used individually or partially or completely mixed with each other to prepare the composition of the present invention. It may also be additionally packaged as a combination composition (such as a kit of dispensing parts) and used. In one embodiment of the invention, the kit may include one or more (including all) components useful for preparing the agrochemical compositions of the present invention. For example, the kit may include one or more fungicide components and/or adjuvant components and/or insecticide components and/or growth regulator components and/or herbicides. One or more components may have been combined in a pre- or pre-provisioning. In embodiments in which two components are provided in a kit, the components may be combined together so that the package is in a single container (such as a vial, bottle, can, pouch, bag or canister. In other implementations) In the example, two or two sets of packages may be separately packaged to "injury", that is, no pre-distribution may be performed. Thus, the kit may include one or more of two types such as a small bowl, a can, a bottle, a pouch. , bag or small can, each bar contains a separate component of the agrochemical composition. In both forms, the components of the kit can be separated from other components or together with other components - as a preparation for the preparation The composition of the composition of the invention of the composition of the invention 3} is applied, a knapsack sprayer, a spray tank or a spray. Here, the concentration to be applied is set with water and/or buffer, and a user may be added as appropriate. The ready-to-use spray or agrochemical group of the present invention is usually obtained by spraying a pre-dosing device onto the aircraft to apply the agrochemical compound of the composition of the present invention to make up the S_149027.doc-214-201103430 2 Hanging through the mouth, every hectare of agriculture has Applying 50 to 500 liters of ready-to-use spray fluid, preferably 100 to 400 liters. According to an embodiment, the individual components of the composition of the invention (such as a portion of a kit or A binary or ternary mixture of trowels) and (right appropriate) additional additives (in-tank mixing) may be added. In another embodiment, the individual components of the composition of the invention may be mixed by a user in a spray tank. Or a partially pre-mixed component (for example, a component comprising the compound Ϊ, Π and/or IV and/or from Group A) to ???) and (if appropriate) additional auxiliaries and additives may be added (in the tank) mixing). In another embodiment, the individual components or portions of the pre-mixed components of the compositions of the invention may be combined (eg, after mixing in a tank) or continuously (eg, comprising Compounds I, ^, and/or 1 ¥ and / Or a component from the active substance of group (4) to ^). Also preferred is a compound I, / or IV (component i) and at least one selected from the group A) of esculine (component 2) and especially selected from the group consisting of atropine, tilmus, oxyfluoride A mixture of the active substances of bacteriocin, kexinxin, oriprozamide, oxystrobin, pyraclostrobin and vinegar. • It is also preferred to include compounds I, II and/or IV (component 1) and at least one carboxamide selected from group B) (component 2) and in particular selected from the group consisting of chlorhexidine, bokley, and sender , cycloheximide, chlorhexidine, isopyrazine, metalaxyl, furosemide, damiden, flumorph, flufenamide (p-benzophenone), benzophenone, gupamine, Mandipropamid and (3,4,5,-trifluorobi-2-yl)-3-difluoroindol-1-yl-1H-indazole-4-indole Mixture of active substances of guanamine 149027.doc -215-201103430. Preference is given to compounds comprising the formula I, hydrazine and/or IV (component 1) and at least one group selected from the group C) (component 2) and especially selected from the group consisting of cycloxazole, difenoconazole, fluorine Cycloazol, fluconazole, flucarbazole, dimethoate, meconazole, madridin, panconazole, propiconazole, propylthioglycol, trimethoate, three tailong, dekli, fluoride A mixture of active substances of ethiazole, cycloxazole, poker, cyanobacteria, benomyl, befenfen and ethipramine. Also preferably, it comprises a compound I, hydrazine and/or (component hydrazine) and at least one heterocyclic compound selected from group D) (component 2) and is especially selected from the group consisting of gibberidine, simboldine and fenremore. , 米潘尼比林, 比利美沙尼,赛福宁,护护f, 菌菌灵' powder rust, thirteen lin, stupid rust bite, yiputong, kekening, famoxadone, Imidazolone, thiabendazole, puquinaz, acidified benzothiadiazole-S-methyl ester, tetradone, fore, phlorin, vebufen and 5_ethyl-6-octyl- [1,2,4] A mixture of active substances of triazolium [15-a]pyrimidin-7-ylamine. Also preferred is a urethane comprising a compound I, hydrazine and/or 1 (component 1} and at least one selected from the group E) (component 2) and especially selected from the group consisting of mancozeb, dysen A mixture of active substances of hydrazine, propyl sulphate, thiram, carbendazim, phenthiali and propamocarb. It is also preferred to include the compound I, π and/or 1 ¥ (component 丨) and at least one selected from the group F) to give the fungicide (component 2) and especially selected from the group consisting of nitrile sulphide, two 〜 - Benxi salt (such as triphenyl vinegar), triethylphosphonic acid, aluminum triethylphosphinate, Hjo and its salts, chlorothalonil, Yifaling, methylpolybao, copper acetate, copper hydride, chlorine oxidation Copper, copper sulphate, sulphur, cymoxanil, mebendazole and snails [S] 149027.doc • 216· 201103430 A mixture of active substances of amines. Accordingly, the present invention is further directed to compositions comprising Compounds I, II and/or IV (Component 1) and another active substance (Component 2) selected from Table C, C-1 to The "Component 2" line listed in C-346. Another embodiment relates to compositions C-1 to C-346 listed in Table C, wherein one of the tables C corresponds in each case to a compound comprising an individualized formula I, II and/or IV of the present specification. (French 1) and the fungicidal compositions of the respective other active substances (component 2) from groups A) to I) as described in the relevant columns. Preferably, the composition comprises a synergistically effective amount of active material. Table C: Composition mixture comprising an individual compound I, II or IV and another active substance from groups A) to I) Component 1 Component 2 C-1 An individualized compound I, II or IV MinC-2 An individualized compound I, II or IV Dimethoprim C-3 An individualized compound I, II or IV enestrobin C-4 An individualized compound I, II or IV fluoxetine C -5 an individualized compound I, II or IV kexin C-6 an individualized compound I, II or IV phenoxystrobin C-7 an individualized compound I, II or IV oriprosamine C-8 Individualized compound I, II or IV oxystrobin C-9 An individualized compound I, II or IV 100 g-sensitive C-10 an individualized compound I, II or IV η ribitola C-11 an individualized compound I, II or IV trifluoro-sensitive C-12 an individualized compound I, II or IV 2-(2-(6-(3-chloro-2-indolyl-phenoxy)-5-fluoro-pyrimidine -4-yloxy)-phenyl)-2-methoxyimino-N-methyl-acetamide C-13 An individualized compound I, II or IV 2-(o-((2, 5-dimercaptophenyl-oxoarhenyl)acyl-acrylic acid (acrylsSure) 6 149027.doc -217- 201103430 Mixture component 1 Component 2 ~ C-14 An individualized compound I, II or IV 3-methoxy-2-(2-(Ν-(4.methoxy)- Styloalkyl sulfoximine iminothiomethyl)-phenyl) propyl decyl C-15 An individualized compound I, II or IV 2-(2-(3-(2,6-dichloro) Phenyl)-1-fluorenyl-siallylaminooxymethyl)-phenyl)-2-methoxyiminoamine·Ν·methyl·ethnamine C-16 an individualized compound I , II or IV Benzophene C-17 An individualized compound I, II or IV phenhydryl-oxime C-18 An individualized compound I, II or IV Malacic C-19 An individualized compound I, II or Rv must kill C-20 An individualized compound I, II or IV Berkeley C-21 An individualized compound I, II or IV Rustone C-22 An individualized compound I, II or IV furosemide C- 23 An individualized compound I, hydrazine or IV Cyclosporin C-24 An individualized compound I, II or IV Fluorine C-25 An individualized compound I, II or IV Furabi C-26 An individualization Compound I, II or rv iso 0 to Z-27 An individualized compound I, guanidine or IV isothiazide C-28 An individualized compound I, II or IV Carrageen C-29 An individualized compound I, II or IV rust-killing amine C-30 An individualized compound I, II or rv Destroy C-31 An individualization Compound I, hydrazine or IV statin- Μ C-32 an individualized compound I, II or IV furosemide C-33 an individualized compound I, II or rv octopus C-34 an individualized compound I, II or IV oxidized rust rust C-35 An individualized compound I, II or IV pirfenamide C-36 An individualized compound I, II or IV Sentence C-37 An individualized compound I, II or rv克枯烂C-38 An individualized compound I, II or IV cyprofen C-39 An individualized compound I, II or IV steroidal C-40 An individualized compound I, hydrazine or IV 2 amine- 4-曱基塞嗤-5· anthranil 149027.doc -218- [si 201103430

Mixture component 1 component 2 C-41 an individualized compound I, hydrazine or IV 2-chlorodimethylindophthyl-4-yl)--prolineamine C-42 an individualized compound I, π or IV N-(3',4f,5-di-fluorobenz-2-yl)-3-dimethylmethyl-bumethyl-1H-pyrazole-4-decylamine C-43 an individualized compound I, II Or IV Ν-(4·-trifluoromethylsulfanylbiphenyl-2-yl)-3-difluoromethyl-1-indolyl-1H-pyrazole-4-decylamine C-44 Compound I, hydrazine or IV N-(2-(l,3-dimercapto-butyl)-phenyl)-1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxamide C-45 An individualized compound I, hydrazine or IV N-(2-(l,3,3-trif-butyl-phenyl)-phenyl)-i,3-dimethyl-5-fluoro-1H- Pyrazole-4-carboxamine C-46 An individualized compound I, II or IV daxanphene C-47 an individualized compound I, II or IV flumorpholine C-48 an individualized compound I, II or IV Ding &quot; 比吗淋C-49 An individualized compound I, hydrazine or IV flumetamide C-50 An individualized compound I, II or IV fluoropyramine C-51 an individualized compound I, II or IV flupirtine C-52 an individualized compound I, II or IV gas benzene Amine C-53 An individualized compound I, II or IV N-(3-ethyl-3,5,5-trimethyl-cyclohexyl)-3-carboxyamino-2-hydroxy-benzamide Amine C-54 an individualized compound I, II or IV gupamine C-55 an individualized compound I, II or IV dioxo (dic.locymet) C-56 an individualized compound I, II or IV Alkyomycin C-57 An individualized compound I, II or IV oxytetracycline C-58 an individualized compound I, II or IV wonderful sulfur C-59 an individualized compound I, II or IV N-(6 -Methoxy-pyridin-3-yl)cyclopropanoic acid decylamine C-60 An individualized compound I, II or IV Azakol 嗤C-61 An individualized compound I, II or IV than donut C- 62 An individualized excimer I, II or IV Bromogram C-63 An individualized compound I, II or IV cycloxazole C-64 an individualized compound I, II or IV difenoconazole C-65 An individualized compound I, II or IV dinitroconazole C-66 an individualized compound I, II or IV dinitroconazole-M 149027.doc • 219-201103430 mixture component 1 component 2 C-67 an individual Compound I, II or IV gas ring β sitting C-68 Individualized compound I, II or IV fenbuconazole C-69 an individualized compound I, hydrazine or IV fluconazole C-70 an individualized compound I, II or IV flucarbazole C-71 Compound I, hydrazine or IV Hydrazine C-72 An individualized compound I, II or IV hexahydrate C-73 An individualized compound I, hydrazine or IV imine D sits C-74 an individualized compound I, II Or IV Epke. Sit C-75 An individualized compound I, π or IV Phytophthora α sit C-76 An individualized compound I, II or IV Maidinidin C-77 An individualized compound I, Π or IV 咪咪β sits C -78 An individualized compound I, II or IV Bark C-79 An individualized compound I, II or IV Penconazole C-80 An individualized compound I, II or IV Propyl-salt C-81 An individual compound I, II or IV propyl thiol ketone C-82 an individualized compound I, II or IV oxime azole C-83 an individualized compound I, II or IV Dekley C-84 an individualized compound I, π or IV fluoroether salivary C-85 an individualized compound I, II or IV trimethoprim C-86 an individualized compound I, hydrazine or IV tri-teronol C-87 an individualized compound I, II or IV ring bacteria ° C -88 an individualized compound I, II or IV. Effect C-89 An individualized compound I, II or IV Κ4-a-phenyl)-2-([1,2,4]triazole-1- ))-cycloheptanol C-90 An individualized compound I, II or IV 赛赛灭C-91 An individualized compound I, II or IV 灭列列 C-92 An individualized compound I, II or IV Column Acidate C-93 An individualized compound I, II or IV rice sulphate C-94 An individualized compound I, II or IV Poker La C-95 An individualized compound I, II or IV Safford C-96 Individualized compound I, II or IV benomyl 149027.doc • 220· [si 201103430 mixture component 1 component 2 C-97 - individualized compound I, II or IV befenfen C-98 an individualized compound I, II or IV Maishenling C-99 an individualized compound I, II or IV thiabendazole C-100 an individualized compound I, II or IV ethipramine C-101 an individualized compound I, II or IV 依得利 C-102 An individualized compound I, II or IV carbendazim C-103 an individualized compound I, II or IV 2-(4-a-phenyl)-N-[4-(3, 4-Dimethoxy-phenyl)-iso-oxo-5-yl]-2-propan-2-freeoxy-acetamide C-104 An individualized compound I, II or IV edugalamine C-105 An individualized compound I, II or IV Tefino C-106 an individualized compound I, II or IV 3-[5-(4-a-phenyl)-2,3-dimethyl-iso Oxazolidine-3-yl] than π-C-107 An individualized compound I, II or IV 3-[5- (4-Methyl-phenyl)-2,3-dimethyl-isoxazole Dang·3·yl]·π ratio '^定C-108 An individualized compound I, II or IV 2,3,5 ,6-tetrachloro__4-曱石黄醯基-°比定定C-109 An individualized compound I, II or IV 3,4,5-dichloro-indole 〇定定-2,6-dicarbonitrile C -110 an individualized compound I, II or IV N-(l-(5-&gt; odor-3 - gas-σ ratio -2-yl)-ethyl)-2,4_diox-final amine C-lll An individualized compound I, II or IV Ν-((5-bromo-3-apiridin-2-yl)-methyl)-2,4-digas--proline amine C-112 Individualized compound I, II or IV sulfamethoxazole C-113 an individualized compound I, II or IV simboldine C-114 an individualized compound I, II or IV diflurine C-115 - an individualized compound I' II or IV fenrimyl C-116 an individualized compound I, II or IV azoxystrobin C-117 an individualized compound I, II or IV rice penicillin C-118 an individualized compound I, II Or IV Chloride C-119 An Individualized Compound I, II or IV Fluoropyrimidinol C-120 An Individualized Compound I, II or IV Bilimecin C-121 An Individualized Compound I, II or IV Funing C-122 An individualized compound I, II or IV Seed dressing C-123 An individualized compound I, II or IV NING 149027.doc -221 - 201103430 Mixture component 1 Component 2 C-124 Individualized compound I, hydrazine or IV adimorpholine C-125 an individualized compound I, II or IV carbendazim C-126 an individualized compound I, II or IV acetaminophen C-127 an individualized compound I , II or IV fine ore, said C-128, an individualized compound I, hydrazine or IV, thirteen, C, 129, an individualized compound I, II or IV, pyridine, C-130, an individualized compound I, π or Rv Fluoroquinone C-131 An individualized compound I, II or IV Escherichia C-132 An individualized compound I, II or IV Fighting C-133 An individualized compound I, π or rv Free Kein C -134 An individualized compound I, II or IV. evil. Phytosinone C-135 An individualized compound I, II or IV ° acetaminophen C-136 An individualized compound I, II or IV Fludonine C-137 An individualized compound I, hydrazine or IV octane. Seming C-138 An individualized compound I, hydrazine or IV thiabendazole C-139 An individualized compound I, hydrazine or IV 5-amino-2-iso-propyl-4-o-indole-based-2 , 3- — Hydrogen·.嗤-1-thio decanoic acid S- succinyl S-C-140 An individualized compound I, hydrazine or IV acidified benzothiadiazole-S- decyl ester C-141 An individualized compound I, II or rv Oxazone C-142 An individualized compound I, π or rv carbendazim C-143 an individualized compound I, II or IV blasticidin-S C-144 an individualized compound I, II or IV Tetragen C-145 An individualized compound I, hydrazine or IV Cappuccine C-146 An individualized compound I, II or IV cockroach C-147 An individualized compound I, II or IV Mailon C-148 An individualized compound I, II or IV imiprozil C-149 an individualized compound I, II or IV sputum C-150 an individualized compound I, II or IV benzoin C-151 an individualized compound I , II or rv thiol sulfonate fast C-152 an individualized compound I, II or IV oxacillin C-153 an individualized compound I, II or IV Forpe 149027.doc • 222 - [si 201103430 mixture Component 1 Component 2 C-154 An individualized compound I, II or IV Oxolins Sure C-155 An individualized compound I, II or IV powder disease C-156 An individualized compound I, II or IV Puccinaz C-157 An individualized compound I, II or IV Hundred Kelvin C-158 An individualized compound I, II or IV veprofen C-159 an individualized compound I , II or IV ° m. saliva C-160 an individualized compound I, II or IV trioxazole C-161 an individualized compound I, II or IV 2 · butoxy · 6 · indole-3-propyl - P克唏-4-画同C-162 An individualized compound I, II or IV 5-gas-1-(4,6-dimethoxy-pyrimidin-2-yl)-2-indenyl-1H- Benzoin»Sit C-163 An individualized compound I, II or IV 5-gas-7-(4-mercapto-piperidinyl-1-yl)_6-(2,4,6-trifluoro-phenyl )-[1,2,4]三峻和[i,5-a] pyrimidine C-164 an individualized compound I, II or IV 5-ethyl·6-octyl-[1,2,4] Triazolo[l,5-a]pyrimidin-7-ylamine C-165 an individualized compound I, hydrazine or IV ferrocene C-166 an individualized compound I, II or IV Individualized compound I, hydrazine or IV mancozegan C-168 An individualized compound I, hydrazine or IV 百 欲 C-169 An individualized compound I, hydrazine or IV Continuum C-170 - individualized I, Π or IV 森森联 C-171 An individualized compound I, hydrazine or IV propyl zinc C-172 An individualized compound I, II or IV thiram C-173 An individualized compound I, II or IV Dessert Zinc C-174 An Individualized Compound I, II or IV Fumei Zinc C-175 An Individualized Compound I, II or IV. Ethylcarbamate C-176 An Individualized Compound I, II or IV Stupid Tully C- 177 An individualized compound I, II or IV 缬 威 C C-178 An individualized compound I, II or IV. Mildew C-179 An individualized compound I, II or IV. Individualized compound I, π or IV Willinphenine C-181 An individualized compound I, II or IV N-(l-(l-(4-cyanophenyl)ethenyl)-but-2- Amino phthalic acid-(4-fluorophenyl) ester • 223· 149027.doc 201103430 Mixture component 1 Component ^ ~~ ' C-182 An individualized compound I, Π or IV 宁宁 — C-183 An individualized compound I, II or IV C-184 an individualized compound I, hydrazine or IV bisindole---- C-185 an individualized compound I, II or IV bisindole acetate - C-186 Compound I, II or IV Bis-octylamine-C-187 An individualized compound I, II or IV Bis-octylamine triacetate C-188 An individualized compound I, hydrazine or IV gram of heat (burning acid salt) C-189 An individualized compound I, hydrazine or IV vincomycin - C-190 An individualized compound I, hydrazine or IV Phytomycin hydrochloride hydrate C-191 An individualized compound I, hydrazine or IV An individual compound I, hydrazine or IV streptomycin C-193 An individualized compound I, hydrazine or IV tyrosin A ' C-194 An individualized compound I, II or IV克C-195 An individualized compound I, π or rv Dicloran C-196 An individualized compound I, II or IV Largely deuterated C-197 An individualized compound I, hydrazine or IV white powder gram C- 198 an individualized compound I, II or IV trifloxystrobin C-199 an individualized compound I, hydrazine or IV tetranitrobenzene C-200 an individualized compound I, II or IV tristinyl salt C-201 Individualized compound I, II or IV nitrile sulfonium C-202 An individualized compound I, hydrazine or IV Indigo C-203 An individualized I, π or rv granules C-204 an individualized compound I, π or rv triethylphosphonic acid, aluminum triethylphosphonate C-205 an individualized compound I, II or IV propyl chelsson C-206 An individualized compound I, II or rv phosphoric acid (H3P〇3) and a derivative C-207 an individualized compound I, hydrazine or IV white pine C-208 An individualized compound I, II or IV Dexon C-209 An individualized compound I, II or IV chlorothalonil C-210 an individualized compound I, hydrazine or IV effluent C-211 an individualized compound I, II or IV bisphenol C-212 an individualized compound I, II or IV fluorosulfurization [si 149027.doc -224- 201103430 Mixture component 1 component 2 C-213 an individualized compound I, II or IV hexabenzene benzene C-214 - individualized compound I, II or IV Binclones C-215 An individualized compound I, II or IV Pentaphenol and its salt C-216 An individualized compound I, II or IV Benzene C-217 An individualized compound I, II or IV quetiacin C -218 An individualized compound I, II or IV methylpolysafe C-219 An individualized compound I, II or IV methyl valproate ^ C-2 20-An individualized compound I, II or IV N-(4-Gas-2-nitro-phenyl)-N-ethyl-4-methyl-benzenesulfonamide C-221 An individualized compound I, II or IV Bordeaux C-222 An individualized compound I, II or IV Copper acetate C-223 - Individualized compound I, II or IV Copper hydroxide C-224 An individualized compound I, II or IV C-225 An individualized compound I, II or IV of copper sulfate C-226 - an individualized compound I, II or IV sulfur C-227. An individualized compound I, II or IV biphenyl C-228 an individualized compound I, II or IV bromoxynol C-229 - an individualized compound I, II or IV thiafenac C-230 an individualized compound I , II or IV sulphonic acid cyanide C-231 an individualized compound I, II or IV diphenylamine C-232 - an individualized compound I, II or IV melfene C-233 - an individualized compound I, II or IV Dictomycin C-234 An individualized compound I, II or IV hydroxyquinoline steel C-235 An individualized compound I, II or IV calcium cyclamate C-236 An individualized compound I, II or IV snail Cyclosporin C-237 - an individualized compound I, II or IV thiol valproate C-238 - an individualized compound I, II or IV N-(cyclopropyl decyloxyimino-(6-di Fluoromethoxy-253-Hrphenyl)-indenyl)_2-phenylethylamine C-239 - Individualized compound I, II or IV N_-(4-(4-gas-3-trifluoro) Indole-stupyloxy)_2,5-dimethyl-phenyl)-N-ethyl-N-mercaptomethylhydrazine C-240 An individualized compound I, hydrazine or IV N'-(4-(4 -1-3-triseodecyl-phenoxy)_2,5-dimethyl-phenyl)-N-ethyl-N-methylformamidine-225 - 149027.doc 201103430 Mixture component 1 Component 2 C-241 An individualized compound I, II or IV N'-(2-methyl-5-trifluoromethyl-4-(3-trimethyldecyl)- Propoxy)-phenyl)-N-ethyl-N-mercaptopurine C-242 An individualized compound I, π or rv NH5-difluorodecyl-2-mercapto-4-(3-tri An individualized compound I, II or IV 2-{1-[2-(5-fluorenyl) -3-trifluoromethyl-pyrazol-1-yl)-ethinyl]-piperidin-4-yl}-thiazole-4-carboxylic acid decyl-(1,2,3,4-tetrazine-na -1-yl), acid sulphate C-244 an individualized compound I, II or IV 2-{ 1-[2-(5-fluorenyl-3-trifluoromethyl-pyrazol-1-yl)- Ethyl]-piperidin-4-yl}-thiazole-4-carboxylic acid decyl-(R)-l,2,3,4-tetrazine-n-yl-Sfeamine C-245 Compound I, II or IV Acetic acid 6-Terbutyl-8-fluoro-2,3-dimethyl-quinolin-4-yl S. C-246 An individualized compound I, II or IV oxime- Acetic acid 6-t-butyl-8-fluoro-2,3-didecyl-indole-4-ylindole C-247 an individualized compound I, II or IV plus Poly C-248 an individualized compound I , II or IV plus C-249 An individualized compound I, II or IV butyl plus Bao C-250 An individualized compound I, II or IV Na Nade thiodicarb C-251 An individualized compound I, II or IV Bifenin C- 252 An individualized compound I, II or IV Safranine C-253 An individualized compound I, II or IV Saining C-254 An individualized compound I, II or IV Sub-Ning C-255 An individual compound I, II or rv ζ-cypermethrin C-256 An individualized compound I, II or IV fentanyl C-257 an individualized compound I, II or IV 益化利 C-258 - an individualized compound I, II or IV λ-赛洛宁 C-259 — Individualized compound I, II or IV 百灭宁 C-260 An individualized compound I, II or rv Tefluthrin C-261 An individualized compound I, II or IV二福隆C-262 An individualized compound I, II or IV Flufuron C-263 An individualized compound I, II or IV Lucendron C-264 An individualized compound I, II or IV Defolon [s ] 149027.doc -226· 201103430 Mixture Component 1 Component 2 C-265 An Individualized Compound I, II or IV Spirotetramat C-266 Individualized compound I, II or IV Cotinine C-267 An individualized compound I, II or IV α-clavamide C-268 An individualized compound I, II or IV etadamine C-269 An individual compound I, II or IV worms. Qin C-270 An individualized compound I, II or IV σ 疋 脉 C C-271 An individualized compound I, II or IV D cecutin C-272 An individualized compound I, II or IV endosulfan C-273 An individualized compound I, II or IV Fenpney C-274 An individualized compound I, II or IV Abatatin C-275 An individualized compound I, II or IV Inhibitor C-276 An individualized compound I , II or IV. C-277 An individualized compound I, II or IV Spinoline C-278 An individualized compound I, II or IV Volt C-279 An individualized compound I, II or IV Insect C. C-280 An Individualized Compound I, II or IV Fenbu C-281 An Individualized Compound I, II or IV Indoxacarb C-282 An Individualized Compound I, II or IV. -283 An individualized compound I, II or IV IL nitramine C-284 An individualized compound I, II or IV Fubenamine C-285 An individualized compound I, II or IV gaseous o-aminobenzamide C-286 An individualized compound I, II or IV nicotinin receptor inhibitor (HGW86) C-287 an individualized compound I, II or IV flumazum C -288 An individualized compound I, II or IV Acetochlor C-289 An individualized compound I, II or IV Methifen C-290 An individualized compound I, II or IV Metolachlor C- 291 An individualized compound I, II or IV. Butachlor C-292 An individualized compound I, II or IV jiaphosphonate C-293 An individualized compound I, II or IV. C-294 An individualized compound I, II or IV thiolopine C- 295 An individualized compound I, II or IV acetyl oxalic acid -227-149027.doc 201103430 Mixture component 1 Component 2 C-296 An individualized compound I, II or IV Oxazolicide C-297 An individual compound I, II or IV 0 is better than fluoxacillin C-298. An individualized compound I, II or IV 11 is more specific than the fluorine gas C-299. An individualized compound I, II or IV Paraquat C-300 An individual compound I, II or IV beetine C-301 an individualized compound I, II or IV gram of grass with C-302 an individualized compound I, II or IV cyclosporin C-303 an individualized compound I, II or IV ring Benzolidone C-304 An individualized compound I, II or IV Pseudomonas C-305 An individualized compound I, II or IV. A herbicide C-306 An individualized compound I, II or IV Pendimethalin C-307 An individualized compound I, II or IV Amphetamine C-308 An individualized compound I, II or IV Trifluralin C- 309 An individualized compound I, II or IV Acifluorfen C-310 An individualized compound I, II or IV bromoxynil C-311 An individualized compound I, II or IV Imazethin C-312 An individual Compound I, II or IV 曱 η 草 草 C C-313 An individualized compound I, II or IV A D σ 坐 nicotinic acid C-314 An individualized compound I, II or IV imazapyrine C-315 An individualized compound I, II or IV imazaquin C-316 an individualized compound I, II or IV imazethapyr C-317 an individualized compound I, II or IV 2,4-diphenoxyacetic acid ( 2,4-D) C-318 An individualized compound I, II or IV Aerosol sensitive C-319 An individualized compound I, II or IV Biekgrass C-320 An individualized compound I, II or IV Fluorine Tobacco C-321 An individualized compound I, II or IV toxin C-322 An individualized compound I, II or IV Fluoropyramine C-323 An individualized compound I, π or rv Bensulfuron-C -324 An individualized compound I, II or IV Ethylsulfuron-C-325 An individualized compound I, II or IV Cyclopropsulfuron-C-326 An individualized compound I II or IV Iodosulfuron 149027.doc -228- [si 201103430 Mixture Component 1 Component 2 C-327 An Individualized Compound I, II or IV Sulfasulfuron-C-328 An Individualized Compound I, II or IV Methylsulfuron C-329 An individualized compound I, II or IV smoke, a long-term C-330, an individualized compound I, II or IV, an imidazosulfuron C-331, an individualized compound I, II or IV flucarbazone C-332 an individualized compound I, II or IV atrazine C-333 an individualized compound I, II or IV hexazine with C-334 an individualized compound I, II or IV diuron C-335 An individualized compound I, II or IV diflufenacil C-336 An individualized compound I, II or IV Prosufene C-337 An individualized compound I, II or IV bentazon C-338 An individualized compound I, II or IV ketoxime C-339 An individualized compound I, II or IV cycloheptyl ether C-340 An individualized compound I, II or IV dicamba C-341 Compound I, II or IV diflupiron C-342 an individualized compound I, II or IV dihaloquinoic acid C-343 Compound I, II or IV Quinoxalic Acid C-344 An Individualized Compound I, II or IV Sulfosyl Ketone C-345 An Individualized Compound I, II or IV Pyrimidinol C-346 An Individualized Compound I , II or IV Topex is known as the active substance of component 2, its preparation and its activity against harmful fungi are known (see, http://www.alanwood.net/pesticides/); Other substances are commercially available. The compounds described by the IUPAC nomenclature, their preparation and their fungicidal activity are also known (see, Can. J. Plant Sci. 48(6), 587-94, 1968; EP-A 141 317; EP- A 152 031; EP-A 226 917; EP-A 243 970; EP-A 256 503; EP-A 428 941; EP-A 532 022; EP-A 1 028 125; EP-A 1 035 122; A 1 201 648; EP-A 1 122 244; JP 2002316902; 149027.doc-229·201103430 DE 19650197; DE 10021412; DE 102005009458; US 3,296,272; US 3,325,503; WO 98/46608; WO 99/14187;

WO 99/24413; WO 99/27783; WO 00/29404; WO 00/46148; WO 00/65913; WO 01/54501; WO 01/56358; WO 02/22583, WO 02/40431; wo 03/10149 WO 03/1 1853; WO 03/14103; WO 03/16286; WO 03/53145; WO 03/61388 WO 03/66609; wo 03/74491; WO 04/49804; WO 04/83193; WO 05/120234 WO 05/123689; WO 05/123690; WO 05/63721; WO 05/87772; WO 05/87773; WO 06/15866; WO 06/87325; WO 06/87343; WO 07/82098; WO 07/90624 ). Mixtures of the active substances may be prepared in the form of compositions by a conventional method, for example, by a method of the compositions of the compounds I, II and/or IV, which compositions comprise at least one inert ingredient in addition to the active ingredient. Ingredients. With regard to the common ingredients of such compositions, reference is made to the explanations for compositions containing compounds I, π and/or IV. Mixtures of the active substances according to the invention are suitable as fungicides. The compounds of the formulae I, II and IV are also suitable as fungicides. It is characterized by significant efficacy against a broad spectrum of phytopathogenic fungi, especially for fungi from the following classes: Ascomycetes, Basidiomycetes, Deuteromycetes and Oomycetes. Further, reference is made to the explanation regarding the fungicidal activity of the compound and the composition containing the compounds I, II and/or IV, respectively. Compounds I, II and IV and their pharmaceutically acceptable salts are also suitable for treatment

SI SI 149027.doc -230- 201103430 Human and animal diseases, especially as anti-mold agents, for the treatment of cancer and for the treatment of viral infections. The term "anti-fungal agent" is different from the term "fungicide" and refers to an agent used against animal pathogenic or human pathogenic fungi, that is, for combating animals, especially mammals (including humans). An agent for fungi in birds. Thus, another aspect of the invention pertains to medicaments comprising at least one compound of the formula I, π and/or IV and/or at least one pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Suitable pharmaceutically acceptable salts are especially the physiologically tolerated salts of Compound I, in particular, physiologically acceptable acid addition salts of acids. Examples of suitable organic and inorganic acids are hydrochloric acid, hydrobromic acid 'phosphoric acid, sulfuric acid, Ci_ CU alkyl sulfonic acid (such as methanesulfonic acid), aromatic sulfonic acids (such as benzenesulfonic acid and toluenesulfonic acid), oxalic acid, cis. Butenedioic acid, fumaric acid, lactic acid, tartaric acid, adipic acid and benzoic acid. Other suitable acid systems are described in the example of WF Artzneimittelforschung, Vol. 10, page 224 ff., Birkhauser Verlag, Basle and Stuttgart, 1966, the entire contents of which are expressly incorporated herein by reference. in. Suitable carriers are, for example, those commonly used in pharmaceutical formulations, sacrificial excipients, binders, and the like, which are described below in an exemplary manner for the particular mode of administration. Another aspect of the invention relates to the use of the compound I, „ and Iv or a pharmaceutically acceptable salt thereof for the preparation of an antifungal agent; that is, for the treatment and/or prevention of human pathogenicity and/or Or an agent for the infection of an animal pathogenic fungus. Another aspect of the invention pertains to a compound of formula I, II and/or IV or 149027.doc 231 201103430 a pharmaceutically acceptable salt thereof for use in the treatment of cancer Use of the agent for use. Another aspect of the invention relates to the use of a compound of the formula π and/or 1 or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment or prevention of a viral infection. The compounds of I, II and IV and/or their pharmaceutically acceptable salts are suitable for the treatment, inhibition or control of the growth and/or proliferation of tumor cells and the conditions associated therewith. SUb 'is suitable for cancer therapy of the following animals: Warm-blooded vertebrates 'for example, mammals and birds, especially males, and other mammals' are particularly useful livestock, such as dogs, cats, pigs, ruminants (bovine, sheep, goats, bison, etc.), horses, and birds. , such as chicken , turkey, duck, goose, guinea fowl and the like. The compounds of formulas I, II and IV and/or their pharmaceutically acceptable salts are suitable for the treatment of cancer or cancerous disorders of the following organs: breast, _ , intestine, prostate, skin (melanoma), kidney, bladder, oral cavity, esophagus, ovary, gonad, liver and brain or CNS. The compounds of the formulae I, II and IV and/or their pharmaceutically acceptable salts are suitable for the treatment of viral infections in the following animals: warm-blooded vertebrates, for example mammals and birds, especially males, and other mammals, especially useful Houses such as dog mnu (bovine, sheep, mountain 'sheep, bison, etc.), horse' and birds, such as chicken, turkey, duck, crane 'beads and their analogues. It is useful for treating viral infections such as retroviral infections such as mV and HTLV, influenza virus infections, rhinovirus infections, cancer treatments and the like. For example, the compound of the present invention can be administered intramuscularly or subcutaneously in a conventional manner by J49027.doc • 232· f S3 201103430. For oral administration, the active compound may be mixed with, for example, an inert diluent or an edible carrier; it may be enclosed in a hard or soft gelatin capsule which may be compressed into a lozenge or may be administered directly Food / feed mix. The active compound may be mixed with excipients and administered in the form of indigestible lozenges, oral solutions, tablets, pills, capsules, suspensions, liquids, syrups and the like. These preparations should contain at least 0.1% active compound. The composition of the formulation may of course vary. The dosage unit usually comprises from 2 to 60% by weight of the active compound. The preferred formulation of the compound 1 of the invention comprises from 10 to 1000 mg of active compound per oral dosage unit. The agent, the pill 'capsule and the like may comprise the following components: a binder such as tragacanth, acacia, corn starch or Mingsheng; an excipient 'such as calcium hydrogen phosphate; a disintegrating agent such as corn starch, potato Starch, alginic acid and the like; a glidant such as magnesium stearate; a sweetener such as sucrose, lactose or saccharin; and/or a flavoring agent such as peppermint, vanilla and the like. Containing a liquid carrier. Other substances which modify the nature of the dosage unit may also be used. For example, the ingot J pellet and the capsule may be coated with schellack, sugar or a mixture thereof. In addition to the active compound, the syrup Or the drink may also contain sugar (or other sweetener), a hydroxybenzoate or a p-hydroxybenzoquinone gamma-Sa coloring agent and/or flavoring agent as a preservative. Of course, the active compound The components of the formulation must be pharmaceutically pure and non-toxic in the amounts used. In addition, the active compound may be formulated as a formulation for controlling the release of the active compound, such as a delayed release formulation. 149027.doc -233 - 201103430 Intestinal or intraperitoneal administration of emollients, compounds, can be prepared using a suitable wet solution or suspension, y, ,) water to prepare the active compound or its salt of the eight teams + glycerol, liquid polyethylene Glycol and its oil

The mixture is prepared to prepare a dispersion T to stop microbial growth. The 匕 special edition agent often additionally contains a preservative to prevent the preparation of the preparation for injection, ', the aqueous solution and dispersion of the bacteria, and the preparation of the sterile solution and the dispersion liquid. The formulation must be sufficiently mobile to be stable under the conditions of manufacture and storage and must be protected from microbial contamination. The carrier can be a solvent or dispersion medium such as water, ethanol, polyol (for example, glycerol, propylene glycol or liquid polyethylene glycol) and mixtures thereof and/or vegetable oils. [Embodiment] The present invention will be further illustrated by the following non-limiting examples. I. Synthesis Example II. Examples of the action against harmful fungi The fungicidal action of the compounds of the formulae 1 and 11 was demonstrated by the following experiment: Α) Microtiter test The active substance was separately formulated into a stock solution in disulfoxide (DMSO). 'The concentration is 10 000 ppm. Use Example 1: Activity against Phytophthora infestans in a microtiter test against a pathogen of late blight. Store the stock solution in a microtiter plate (MTP) and dilute it to the specified active substance using a pea juice-based aqueous nutrient medium for fungi. Agricultural degree. An aqueous suspension of zoospores of Phytophthora infestans is then added. Place the plate at 149027.doc -234- 201103430 at a temperature of 18. (: In a room where water vapor is saturated. Using an absorption photometer, Μτρ is measured at 405 nm on the 7th day after inoculation. The measured parameters are compared with the control variant without active substance (=1%%) The growth was compared and compared to the blank test values without the true and active substances to determine the relative growth % of the pathogen in the individual active substances. Example 2: In the microtiter test against P. Activity of the caused rice blast pathogen The stock solution is inhaled into a microtiter plate (MTp) and diluted to the specified active substance concentration using a malt-based aqueous nutrient medium for fungi. Subsequently, an aqueous suspension of spores of P. sphaeroides is added. The plate was placed in a water vapor-saturated chamber at a temperature of 18 ° C. The microtiter plate was measured at 405 nm on the 7th day after inoculation using an absorption photometer. The measured parameters were not active. The growth of the control variants (= 1%) was compared and compared to the blank test values for fungi and active substances to determine the relative growth of the pathogen in the individual active substances. Example 3: In the microtiter test against the activity of the sclerotium plaque pathogen caused by the bacterium of the bacterium, the stock solution was inhaled into the microtiter plate (MTp) and the malt base for fungi was used. The aqueous nutrient medium is diluted to the specified active substance concentration. Subsequently, an aqueous suspension of spores of S. cerevisiae is added. The dish is placed in a water vapor-saturated chamber at a temperature of 18 ° C. Inoculation is carried out using an absorption photometer. The microtiter plate was then measured at 405 nm on day 7. The measured parameters were compared to the growth of the control variant (=1〇〇%) without active substance i and the blank without fungi and active substances The test values were compared to determine the relative growth % of the pathogen I49027.doc -235· 201103430 in individual active substances. B) Greenhouse test The active substance was formulated separately or together to form a stock solution containing 25 mg of active substance. / or a mixture of bismuth stone (DMSO) and emulsifier Wettol EM 3 1 (ethoxylated phenol based humectant with emulsification and dispersion) as solvent / emulsifier 99:1 Ratio thereof to make up 10 ml. The solution was then made up to 1 〇〇 ml with water. This stock solution was diluted with the solvent/emulsifier/water mixture to the concentration of active material given below. Use of Example 4 for protective application against the activity of P. oxysporum caused by Phytophthora infestans causes the growth of the plant seedlings in the pot. The plants are sprayed with an aqueous suspension containing the active substance concentrations specified below until overflowing. The next day, the treatment group was inoculated with an aqueous suspension of the Phytophthora infestans sporangia. Immediately after inoculation, the test plants were transferred to a humid chamber. After 6 days at a relative humidity of 丨8 to 2 (rc and close to 100%), the degree of fungal attack on the leaves was visually evaluated, expressed as % of diseased leaf area. Example 5: Against Puccinia striiformis on wheat (Therapeutic effect of wheat brown rust) The potted wheat seedling leaves of the cultivar "Kanzler" were sprayed with a spore suspension of wheat brown rust (Puccinia recondita). The plants were then placed in high atmospheric humidity (90 to 95%). And indoors of 20-221 for 24 hours. During this period, the spores germinate and the germ tube penetrates into the leaf tissue. The secondary sputum sprays the infected plants with an aqueous suspension having the concentration of the active substance specified below until the overflow point. [S1 149027.doc • 236· 201103430 After drying the sprayed suspension, the test plants are returned to the greenhouse and cultured for a further 7 days at a temperature between 2 and 22 ° C and a relative atmospheric humidity of 65 to 7 %. The degree of rust progression on the leaves was then visually observed. Use Example 6: Protective effect against Puccinia glabrata (wheat brown rust) on wheat Spray cultivar Ka with an aqueous suspension having the concentration of active substance specified below The basin of the "nzler": the leaves of the wheat seedlings were planted until the overflow point. The next day, the plants were sprayed with the spore suspension of wheat brown rust (Puccinia recondita). The plants were then placed in high atmospheric humidity (9〇 to 95). %)&amp;2〇_22t2 indoor 24 hours. In this period μ, spores germinate and the germ tube penetrates into the leaf tissue. The next day, the test plants are returned to the greenhouse and the temperature between 2〇 and 22. 65 to 7G% of the relative atmospheric humidity for another 7 days. Then visually measure the degree of progress of the disease on the leaf. Use Example 7 to protect the protective effect of wheat powdery mildew (wheat powdery mildew) on wheat with the following provisions The aqueous suspension of the active substance concentration is sprayed on the potted wheat seedling leaves of the cultivar Kanzler until the overflow point. The next day, the spore suspension of wheat powdery mildew (wheat powdery mildew) is sprayed with the plants, and then the plants are planted. Return to the greenhouse and the temperature between 2 (&gt; and depression) and 60 to 90% of the strokes were further incubated for the day under atmospheric humidity. Then the degree of powdery mildew progress on the leaves was visually observed. Example 8: Against the sage of the squash Ear monofilament The protective effect of the fungus (courgette powdery mildew), the water content of the active substance concentration of the following regulations &spray; spray pot 149027.doc -237· 201103430 The leaves of the cucurbit seedlings (at the stage of the germ layer) until the overflow point. The treated group of plants is sprayed with a spore suspension of the squash powdery mildew (Spirulina solani) and the plants are then returned to the greenhouse for re-expansion at relative atmospheric humidity. The temperature between 20 and 24 ° C and 60 to 80 %. Raise for 7 days. Then visually measure the powdery mildew on the cotyledons.

[SI 149027.doc 238

Claims (1)

201103430 VII. Patent application scope: 1. Formula I and 11 bis π sitting compounds, A wherein Ar Het is a 3-, 4-, 5-, 6-heterocyclic ring which may have 1, 2 or 3, wherein the heterocyclic R 3 ; or 5 substituent R 2 is phenyl, Or is the hetero atom of =N, Ο, and S as a ring member or? , saturated, partially unsaturated or aromatic, having 1, 2, 3 or 4 substituents having 12 or 3 heteroatoms selected from N, ◦ and S as ring members 3-, 4-, 5 -, 6 . a 7-membered saturated, partially unsaturated or aromatic heterocyclic ring wherein the heterocyclic ring has a 1, 2, 3 or 4 substituent R4; A is 1, 2, 3 or 4 linear alkyl bridges substituted with substituent R5; Y is 0, S or NR6; R is selected from hydrogen, α-(:10 alkyl, Cl_c10 haloalkyl, 匚2-(:10 alkenyl, C2 -Ci〇 〇 坤, C2'Ci 〇 fast radical, C2_Ci 〇 fast radical, cycloalkyl, C3_C1 () ii cycloalkyl, phenyl, phenyl _Ci_ C4 alkyl, of which the last two are mentioned The phenyl moiety in the group may be 149027.doc 201103430 having: 2, 3, 4 or 5 substituents R' and containing 2 or 3 heteroatoms selected from and S as a ring (4) 5_ or 6_ member Saturated, partially unsaturated or aromatic, ay, wherein the heterocyclic ring may have 1, 2 or 3 substituents; or m is oxime, may also be selected from -C(=0)R, -C (=s)r8, R9R丨0, Μ and the group of the formula in-CN, -P(Q) A (III) wherein Ar, Het, A and Y are as defined in Formula 1 and „; and # is the point of attachment to the rest of the molecule. Is selected from the group consisting of hydrogen, CVCw alkyl Ci-C10 haloalkyl, C2_Cl nonenyl, c2-c1G-alkenyl, c2_Cig fast radical, c2_CiG alkynyl, 匸3-匸10 cycloalkyl, (: 3-( : 1 〇 halocycloalkyl, phenyl, phenyl _c "C4 alkyl, wherein the phenyl moiety in the last two mentioned groups may have 1, 2, 3, 4 or 5 substituents r7, containing 2, or 3, 5 or 6-membered saturated, partially unsaturated or aromatic heterocyclic rings selected from the group consisting of N, anthracene and S, wherein the heterocyclic ring may have 1, 2 or 3 substituents. Base rule 7, -^:^^!]^, ^:"..., -S(0)2R8, -CN, -P(=Q) r9ri〇 and M; LSI 149027.doc 201103430 Each R2 is independently selected from Halogen, hydrazine H, SH, NO, CN, (: 丨-(: 4 alkyl, CVC4 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, c2-匚4 fast radical, C2-C4 _ fast base, C3-C8 ring entertainment base, C3-C8 fluorene cycloalkyl, CVC4 alkoxy, C "C4 haloalkoxy, CVC4 alkenyloxy, C1-C4 halooxy, C1-C4 alkyne Oxy, (^-〇4 halooxy, c3-c8 cycloalkoxy, c3-c8 halocycloalkoxy, Cl-C4 alkylthio, C1-C4 halogen-sulphur, C1-C4 sulfur Base, C1-C4 13⁄4 fast stone ·》» , a phenyl phenyl sulfonium group, a phenyl alkoxy group, a phenoxy group, a phenylthio group, wherein the phenyl moiety in the last five mentioned groups may have 1, 2, 3, 4 Or 5 substituents ru; % 4 5 or a saturated, partially unsaturated or maximally unsaturated heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, fluorene and 8 as ring members, wherein the heterocyclic ring may be Having i, 2 or 3 substituent bases 11丨C〇R, COORl2, CONR13R14, NRnR14 and s(o)pRU, wherein the aliphatic or the three substituents in the above group r15^兵1P are in the above group The cycloaliphatic moiety may have 1, 2 or 3 substituents of the base 10; or two groups R2 attached to the adjacent carbon ring calendar atom together with the nucleus to which it is attached - .6 .7 D Forming a partially unsaturated or maximally unsaturated 5- or 7-shell carbocyclic ring, ^ μ ^ V. . . 5 3 having i, 2 or 3 selected from 0, S and Ν <heteroatom as ring-out '6- ^7 I μ of partially unsaturated or maximally unsaturated 5 - &amp; 7-membered heterocyclic ring; which is 3 substituents R11 . , rabbit nucleus or heterocyclic ring may have 1, 2 or each R 3 independently selected from the south , SH, N02, CN, C] _C4 alkane I490 27.doc 201103430, C1-C4 halo, C2-C4, C2-C4 halo, 匸C4 alkynyl, C2-C4 haloalkynyl, C3-C8 cycloalkyl, C3-c8 _ ring Hyun, C]-C4 methoxy, C1-C4 halooxy, (^-〇4 dilute gas, C1-C4 halooxy, C1-C4 oxy, C1-C4 haloalkyne , C3-C8 cyclodextro-oxy, C3-C8 halocycloalkyloxy, thio, C1-C4 halogen thio, C1-C4 disulfide, dentate, phenyl, phenyl-C1- a C4 alkyl group, a phenoxy group, a phenoxy group, a phenylthio group, wherein the phenyl moiety in the last five mentioned groups may have 1, 2, 3, 4 or 5 substituents R11; 2 or 3 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated heterocyclic rings selected from heteroatoms of N, hydrazine and S as ring members wherein the heterocyclic ring may have 1 , 2 or 3 substituents r 11 . COR12 'COOR12 . conr13r14 . NR13R14AS(〇) R12, wherein the aliphatic moiety of the above group may have i, 2 or 3 substituents R15, wherein the ring in the above group The aliphatic moiety can have 1, 2 or 3 substituents; or SH, N〇2, CN, CVQ alkenyl group, c2-c4 haloalkenyl group, c2-149027.doc 201103430 C4 alkynyl group, c2-c4 alkynyl group, (: 3-(:8-cycloalkyl group, c3- C8 halocyclyl, c丨-C4 alkoxy, Cl_C4 haloalkoxy, c丨-C4 alkenyloxy, Cnc4 haloalkenyloxy, Cl-c4 alkynyloxy, C/C4 haloalkoxy, c3 -c8 cycloalkoxy, c3-c8 halocycloalkoxy, C--C4 alkyl group C1-C4 halogen thiol, C1-C4 thiol, (1:1-〇14_block thio, Phenyl, phenyl-Cl-C4 alkyl, phenyl-Cl_C4 alkoxy, phenoxy, phenylthio, wherein the stupid moiety in the last five mentioned groups may have 1, 2, 3, 4 Or 5 substituents R1!; 3, 4, 4, 5, 6 or 7 containing 1, 2 or 3 heteroatoms selected from N, 〇 and S as ring members saturated, partially unsaturated or maximal a saturated heterocyclic ring wherein the heterocyclic ring may have 1, 2 or 3 substituents Rn; 1, 2 or 3 substituents R16; or Each ruler 5 is independently selected from the group consisting of halogen, OH c]-c4 dentate 'C2-C4 dilute base' c base, Ρr gan , 丞' gynecological, C2_Cj C1-C4 decyloxy, c, C1-C4 halogenated oxygen c2-c4 _ alkynyl, I49027.doc 201103430 1 c4 hospital thiol and CVC4 sulphide thiol ' among the above groups The aliphatic moiety may have i, 2 or 3 substituents Rl5, or two groups R5 attached to two adjacent carbon atoms together with the carbon atom to which they are attached - form 3_, 4_, 5_, 6 _ or 7 members of saturated or unsaturated carbon rings, or containing 1, 2, or 3 heteroatoms selected from ruthenium, as a ring member, 3-, 6 or 7-member saturated, partially unsaturated or maximal And the heterocyclic ring, wherein the carbocyclic or heterocyclic ring may have an anthracene, 2 or 3 substituents R11: R6 is selected from the group consisting of hydrogen, CN, Cl_c4, Ke_c4 _ 院, c2_c4 alkenyl, cvcu, C2_c4 alkynyl, c2_C4i alkynyl, Cl_C4 alkoxy, C1_C4 haloalkoxy, phenyl, phenylalkyl, wherein the phenyl moiety in the last two mentioned groups may have 1, 2, 3, 4 or 5 substituents R&quot;; c: 〇R 〖2, c〇〇Ri2, C〇NRuR14 and s(〇)pr丨2; each r7 is independently selected from halogen, OH, SH, NR丨3R14, CN, N02 , burning base, Ci-CUil burning , c2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 block, c2-C4 alkynyl, CVC4 methoxy, CV alkoxy, (VC4 alkylthio &amp; (ν(:4) a haloalkylthio group wherein the aliphatic moiety of the above group may have 1, 2 or 3 substituents R15; R is selected from the group consisting of hydrogen, C|'C10 alkyl, CVC丨〇 haloalkyl, (^-( Alkoxy, CVCk haloalkoxy, CVCM aminoalkyl, C3-C10 cycloalkyl, C:3-C丨〇halocycloalkyl, phenyl, phenyl 149027.doc [S1 201103430 base, wherein The stupid base moiety in the last two mentioning groups may have a small (4) substituent, a hetero atom containing N, 0 and S as a ring member, or a partial or not a saturated or aromatic heterocyclic ring, wherein the heterocyclic ring may have i, ... substituents R7, and NR13R14; R9 and R1G are independently of each other selected from the group consisting of q-Cw alkyl Cl-Cl〇 haloalkyl, C, -c10 dilute Base, c2-c10(tetra)yl, c2_Ci〇 block, C2_Ci〇南快基, c3-c1G cycloalkyl, c3_ClQ_cycloalkyl, alkoxy, CVCw halooxy, Cl_cDowyl-CiCi. Ci-C^ alkoxy-Ci-Cio alkoxy group, Cl_CiQ sulphur group, c〗 _Ca tooth sulphur group, hydrazine 2-(:10 alkenyloxy, c2_Ci〇 dilute thio, c alkynyloxy, c2-c1()alkynylthio, c3_ClG cycloalkoxy, c3_Cic cycloalkylthio, phenyl, phenyl-C^C : 4 alkyl, phenylthio 'phenyl-CVC4 alkoxy and NRnR14; each R is independently selected from the group consisting of halogen, OH, SH, NR13R14, CN, N〇2, Ci-C4 alkyl, ke, c2-c4 Alkenyl, c2-c4 alkenyl, c2-c4 alkynyl, c2-c4 haloalkynyl CVCU alkoxy, CV C4 haloalkoxy, Ci-q alkylthio and (^-(:4halane) a thio group, wherein the aliphatic moiety in the above group may have 1, 2 or 3 substituents R15; each han 12 is independently selected from the group consisting of hydrogen, c--c4 alkyl, Ci-C4 haloalkyl, c2-c4 Alkenyl, c2-c4 haloalkenyl, CVC4 aminoalkyl, phenyl, phenyl-C1-C4 alkyl, wherein the phenyl moiety in the last two mentioned groups may have 1, 2, 3, 4 Or 5 substituents R11, and 5 or 6 membered saturated, partially unsaturated or aromatic heterocyclic rings containing 1, 2 or 3 149027.doc 201103430 heteroatoms selected from N, 0 and S as ring members The heterocyclic ring may have 1, 2 or 3 substituents R11; each R13 is independently selected from hydrogen and &lt;^-(:8 alkyl; each R14 is independently selected from hydrogen C,-C8 alkyl, phenyl and phenyl-Ci_c4 alkyl; or R and R together form a straight or Cs alkyl bridge or group -CH2CH2OCH2CH2-5t-CH2CH2NRI7CH2CH2-; each R is independently selected from Base, CN, oh, COR12, COOR12, C0NRnRH; nr13rI4, C3_c6 cycloalkyl, (VC: 6 halocycloalkyl, (: 丨-(:4 alkoxy, c丨_C4 haloalkoxy, Cs) -C6 cycloalkoxy (cyci〇ai〇xy), phenyl and phenoxy; each R is independently selected from the group consisting of schlossyl, Cn, 〇H, SH, COR丨2, COOR·2, C0NRnRl4, nr13r14, Ci C47 , C 4 haloalkyl, (: 3-(:6 cycloalkyl, C3_C6 halocycloalkyl, Ci_C4 alkoxy, CrC4 haloalkoxy, c3-C6 cycloalkoxy, phenyl and phenoxy) Each R丨7 is independently selected from hydrogen and Ci_c4 alkyl; Q is hydrazine or s; M is a metal cation equivalent or an ammonium cation of the formula (NRaRbReRd)+ wherein Ra, Rb, RC and Rd are independently selected from each other Hydrogen, C"10 10, phenyl and benzyl, wherein the phenyl moiety of the last two mentioned groups may have 1, 2 or 3 substituents independently selected from the group consisting of: Nitro, alkyl, C/C4 halo 149027.doc 14 201103430 m base, (VC4, oxy, alkoxy and 13Ri are 〇, 1 or 2; and P is 1 or 2; and agriculturally acceptable salts thereof. 2. As requested! And a compound of „, wherein ^ is a phenyl group which may have 2, 3" or 5 substituents, or 5_ or 6_ containing a hetero atom selected from N, oxime and S as a ring member A heteroaromatic ring wherein the heteroaromatic ring may have 1, 2, 3 or 4 substituents R3. 3. Recognizing the compound as claimed in claim 2, wherein ^ is 1, 2, 3, 4 or 5 'preferably fluorene, 2 or 3 substituents phenyl, or selected from: pyridine Base, pyrimidinyl, anthraquinone, thienyl, pyrrolyl, pyridyl, oxazolyl: oxazolyl, isoxazolyl, thiazolyl, isothiazolyl and triazolyl 5- or 6-membered An aromatic ring wherein the heteroaryl ring may have 1, 2, 3 or 4, preferably 1 or 2 substituents R3. 4. A compound of formula 1 and II according to claim 3, wherein Ar is a phenyl group which may have 2, :, 4 or 5 'preferred oximes, 2 or 3 substituted groups 2, or selected from the group consisting of The 5- or 6-membered heteroaryl ring of the thienyl group and the thiazolyl group is preferably pyridinium: the heteroaryl ring may have an anthracene. Or 4, preferably 1 or 2 5. The compound of the formula of any one of the claims, wherein this is 3. And 2 or 3 5- or 6: bet-heterocyclic rings selected from the group consisting of a hetero atom of ruthenium, osmium and S as a ring member, wherein the heteroaromatic ring may have 1, 2, 3 or 4 substituents R. Soil 6. The compound of claim 5, wherein Het is selected from the group consisting of 149027.doc 201103430 pyrimidinyl, furyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, isomer A 6-membered heteroaryl ring of oxazolyl, thiazolyl, isothiazolyl and triazolyl, wherein the heteroaryl ring may have fluorene, 2, 3 or 4, preferably 2 or 2 substituents R4. 7) A compound of the formulae I and II according to claim 6, wherein Het is a 5- or 6-membered heteroaryl ring selected from the group consisting of pyridyl, thienyl and thiazolyl, preferably pyridyl, wherein the itch heteroaryl ring is There are 1, 2, 3 or 4, preferably oxime or 2 substituents R4. 8. The compound of formula 1 and π according to any of the preceding claims, wherein R2, r3 and R4 are independently of each other and are each independently selected from the group consisting of halogen, OH, SH, N〇2, CN, Ci-C. ^Acetyl, C^-C* functional base, alkoxy-C^C^ alkyl, C|-C4 alkoxy, C|-C4 alkoxy alkoxy and CVC41|alkoxy Preferably, it is selected from the group consisting of hydrogen, fluorine, gas, bromine, Ci_c4^, CVC4 haloalkyl, (^-(^ alkoxy and C|-c4 haloalkoxy). 9. Formula according to any of the preceding claims a compound of I and π, wherein Rs is selected from the group consisting of c丨-c4 alkyl, c丨-c2 haloalkyl, C-C4 alkoxy, Ci-C2 haloalkoxy, phenyl, phenoxy and NR13R14 Wherein R13 is hydrogen, R&quot; is selected from the group consisting of hydrogen, c"c4 alkyl and phenyl, or r&quot; are both Ci_c4 alkyl. 10. A compound of formula 1 &amp; π according to any of the preceding claims, Wherein R1 is selected from the group consisting of hydrogen, C-C4 alkyl, _C(=〇)R8, -S(0)2R8, _CN, hydrazine and a hydrazine group, preferably selected from the group consisting of hydrogen, fluorenyl and ethyl. Propyl, isopropyl, -c(=〇)ch3, -C(==0)0CH3, _C(=0)N(CH3)2, CN, a group of formula III, an alkali metal cation, and cu2+. _ as requested above A compound of any of formulas I and II, wherein 1113 is selected from the group consisting of [S] 149027.doc -10·201103430 from hydrogen, Crq alkyl, _S(0)2R8 and -C(=0)R8. A compound of any one of the preceding claims, wherein the eighth is a linear C2 or C3 alkylene bridge, wherein the alkyl or two hydrogen atoms of the alkylene bridge may be replaced by one or two substituents r5, wherein each R5 Independently selected from the group consisting of ^-^alkyl, c丨-c4_alkyl, Cl_C4 alkoxy, Ci_C4 alkoxy-c丨^alkanyl and C!-C4 halooxyl is preferably selected from methyl The ethyl, decyloxy, ethoxy, and methoxymethoxy groups, or the two substituents R5 attached to adjacent carbon atoms, together with the carbon atom to which they are attached, form a cyclopentyl or cyclohexyl ring. The compound of the formula I and the compound of any one of the preceding claims, wherein γ is 0. 14. The compound of the formulae 1 and 11 according to any of the preceding claims, wherein the paw is ruthenium. Compound, Wherein Ar, Het, Α and Υ are as defined in any one of claims 1 to 8 and 12 to 14. 16. An agricultural composition comprising at least one compound of formula I, II and/or IV according to any one of claims 1 to 5, or an agriculturally acceptable salt thereof, and a liquid or solid carrier. 17. The use of a compound of the formula ii15 or a compound of 149027.doc -11 - 201103430 for the control of harmful fungi. 〗 〖8. A method for controlling harmful fungi, wherein the fungus, its habitat or by:, remedy and fungal attack material or plant, or soil or reproductive material is at least an effective amount of Treatment with a compound of IV or IV, wherein compounds I, II and V are as defined in any one of claims i to J5. a seed containing from 1 g to 1 kg per 100 kg of seed to a compound of formula I, II and/or IV, wherein compound J, MW is as claimed in any of claims 1 to 15. Defined by item. 20. A pharmaceutical composition comprising at least one compound of formula I, II and/or IV according to any one of claims 1-4, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable Carrier. 21. The use of a compound of the formula π&amp;/or ^ or a pharmaceutically acceptable salt thereof according to any one of claims 1 to 15 for the preparation of a medicament for the treatment of cancer or a viral infection or For the preparation of anti-mold agents. 2 2. A method of treating a cancer or a disease infection or combating an animal pathogenic or human pathogenic fungus comprising at least one of formulas I, II and/or IV according to any one of claims 1 to 15. A compound, at least one pharmaceutically acceptable salt thereof, or a pharmaceutical composition according to claim 20, is used to treat an individual in need thereof. 149027.doc •12- 201103430 IV. Designated representative map: (1) The representative representative of the case is: (none) (2) The symbol of the symbol of the representative figure is simple: 5. If there is a chemical formula in this case, please reveal the best display. Chemical formula of the inventive feature: LSI 149027.doc