SG11202106198YA - Antibody that binds to vegf and il-1beta and methods of use - Google Patents
Antibody that binds to vegf and il-1beta and methods of useInfo
- Publication number
- SG11202106198YA SG11202106198YA SG11202106198YA SG11202106198YA SG11202106198YA SG 11202106198Y A SG11202106198Y A SG 11202106198YA SG 11202106198Y A SG11202106198Y A SG 11202106198YA SG 11202106198Y A SG11202106198Y A SG 11202106198YA SG 11202106198Y A SG11202106198Y A SG 11202106198YA
- Authority
- SG
- Singapore
- Prior art keywords
- 1beta
- vegf
- binds
- antibody
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18215023 | 2018-12-21 | ||
| PCT/EP2019/086529 WO2020127873A1 (en) | 2018-12-21 | 2019-12-20 | Antibody that binds to vegf and il-1beta and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202106198YA true SG11202106198YA (en) | 2021-07-29 |
Family
ID=64870356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202106198YA SG11202106198YA (en) | 2018-12-21 | 2019-12-20 | Antibody that binds to vegf and il-1beta and methods of use |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11130804B2 (en) |
| EP (1) | EP3898671A1 (en) |
| JP (3) | JP7114813B2 (en) |
| KR (2) | KR102652720B1 (en) |
| CN (1) | CN113195531A (en) |
| AR (1) | AR117468A1 (en) |
| AU (1) | AU2019406712A1 (en) |
| BR (1) | BR112021012022A2 (en) |
| CA (1) | CA3123503A1 (en) |
| CL (1) | CL2021001616A1 (en) |
| CO (1) | CO2021008755A2 (en) |
| CR (1) | CR20210332A (en) |
| IL (1) | IL283566A (en) |
| MX (1) | MX2021007421A (en) |
| PE (1) | PE20211294A1 (en) |
| SG (1) | SG11202106198YA (en) |
| TW (1) | TW202039552A (en) |
| WO (1) | WO2020127873A1 (en) |
| ZA (1) | ZA202103643B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20230986A1 (en) | 2020-09-04 | 2023-06-21 | Hoffmann La Roche | ANTIBODY THAT BINDS VEGF-A AND ANG2, AND METHODS OF USE |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US830930A (en) | 1905-11-22 | 1906-09-11 | E & T Fairbanks & Co | Weighing-scale. |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| JP3101690B2 (en) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | Modifications of or for denatured antibodies |
| DK0564531T3 (en) | 1990-12-03 | 1998-09-28 | Genentech Inc | Enrichment procedure for variant proteins with altered binding properties |
| DE69233254T2 (en) | 1991-06-14 | 2004-09-16 | Genentech, Inc., South San Francisco | Humanized Heregulin antibody |
| US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
| JPH08511420A (en) | 1993-06-16 | 1996-12-03 | セルテック・セラピューテイクス・リミテッド | Body |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| JP2002506353A (en) | 1997-06-24 | 2002-02-26 | ジェネンテック・インコーポレーテッド | Methods and compositions for galactosylated glycoproteins |
| DE69840412D1 (en) | 1997-10-31 | 2009-02-12 | Genentech Inc | METHODS AND COMPOSITIONS CONTAINING GLYCOPROTEIN GLYCOR FORMS |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| EP1068241B1 (en) | 1998-04-02 | 2007-10-10 | Genentech, Inc. | Antibody variants and fragments thereof |
| PT1071700E (en) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| WO2000005319A1 (en) | 1998-07-23 | 2000-02-03 | Coöperatieve Verkoop- En Productievereniging Van Aardappelmeel En Derivaten Avebe B.A. | Adhesive composition |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| PL209786B1 (en) | 1999-01-15 | 2011-10-31 | Genentech Inc | Variant of mother polypeptide containing Fc region, polypeptide containing variant of Fc region with altered affinity of Fc gamma receptor binding (Fc R), polypeptide containing variant of Fc region with altered affinity of Fc gamma neonatal receptor binding (Fc Rn), composition, isolated nucleic acid, vector, host cell, method for obtaining polypeptide variant, the use thereof and method for obtaining region Fc variant |
| US20030180714A1 (en) | 1999-12-15 | 2003-09-25 | Genentech, Inc. | Shotgun scanning |
| NZ603111A (en) | 2001-08-03 | 2014-05-30 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| BR0213761A (en) | 2001-10-25 | 2005-04-12 | Genentech Inc | Compositions, pharmaceutical preparation, industrialized article, mammalian treatment method, host cell, method for producing a glycoprotein and use of the composition |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| CA2481657A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Cells of which genome is modified |
| EP1498490A4 (en) | 2002-04-09 | 2006-11-29 | Kyowa Hakko Kogyo Kk | Process for producing antibody composition |
| ATE503829T1 (en) | 2002-04-09 | 2011-04-15 | Kyowa Hakko Kirin Co Ltd | CELL WITH REDUCED OR DELETED ACTIVITY OF A PROTEIN INVOLVED IN GDP-FUCOSE TRANSPORT |
| US20050031613A1 (en) | 2002-04-09 | 2005-02-10 | Kazuyasu Nakamura | Therapeutic agent for patients having human FcgammaRIIIa |
| EP1498491A4 (en) | 2002-04-09 | 2006-12-13 | Kyowa Hakko Kogyo Kk | METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO Fc GAMMA RECEPTOR IIIa |
| CA2488441C (en) | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| HU227217B1 (en) | 2002-12-16 | 2010-11-29 | Genentech Inc | Immunoglobulin variants and uses thereof |
| CA2510003A1 (en) | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
| EP1587921B1 (en) | 2003-01-22 | 2010-07-28 | GlycArt Biotechnology AG | Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| NZ549872A (en) | 2004-04-13 | 2009-09-25 | Hoffmann La Roche | Anti-P-selectin antibodies |
| TWI380996B (en) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| CA2580141C (en) | 2004-09-23 | 2013-12-10 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| JO3000B1 (en) | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. |
| RS59761B1 (en) | 2005-02-07 | 2020-02-28 | Roche Glycart Ag | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
| EP2465870A1 (en) | 2005-11-07 | 2012-06-20 | Genentech, Inc. | Binding polypeptides with diversified and consensus VH/VL hypervariable sequences |
| WO2007064919A2 (en) | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| EP2016101A2 (en) | 2006-05-09 | 2009-01-21 | Genentech, Inc. | Binding polypeptides with optimized scaffolds |
| WO2008027236A2 (en) | 2006-08-30 | 2008-03-06 | Genentech, Inc. | Multispecific antibodies |
| DE102007001370A1 (en) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-encoded antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| KR20150036824A (en) | 2009-03-20 | 2015-04-07 | 제넨테크, 인크. | Bispecific anti-her antibodies |
| AU2011265054B2 (en) | 2010-06-08 | 2016-09-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| PT2691417T (en) | 2011-03-29 | 2018-10-31 | Roche Glycart Ag | Antibody fc variants |
| AU2012265156B2 (en) | 2011-05-27 | 2017-01-19 | F. Hoffmann-La Roche Ag | Dual targeting |
| ES2676031T3 (en) | 2012-02-15 | 2018-07-16 | F. Hoffmann-La Roche Ag | Affinity chromatography based on the Fc receptor |
| HUE056217T2 (en) | 2012-07-13 | 2022-02-28 | Roche Glycart Ag | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
| PE20190920A1 (en) | 2013-04-29 | 2019-06-26 | Hoffmann La Roche | MODIFIED ANTIBODIES OF BINDING TO HUMAN FCRN AND METHODS OF USE |
| UA117289C2 (en) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Multispecific antibodies |
| EP3174897B1 (en) | 2014-07-29 | 2020-02-12 | F.Hoffmann-La Roche Ag | Multispecific antibodies |
| SG11201701128YA (en) | 2014-09-12 | 2017-03-30 | Genentech Inc | Cysteine engineered antibodies and conjugates |
| CA2963719A1 (en) * | 2014-11-10 | 2016-05-19 | F. Hoffmann-La Roche Ag | Anti-il-1beta antibodies and methods of use |
| KR20170080584A (en) * | 2014-11-10 | 2017-07-10 | 에프. 호프만-라 로슈 아게 | Bispecific antibodies and methods of use in ophthalmology |
| WO2017079768A1 (en) * | 2015-11-08 | 2017-05-11 | Genentech, Inc. | Methods of screening for multispecific antibodies |
| WO2018060035A1 (en) * | 2016-09-30 | 2018-04-05 | F. Hoffmann-La Roche Ag | Spr-based dual-binding assay for the functional analysis of multispecific molecules |
| MX2019012381A (en) * | 2017-05-18 | 2020-01-23 | Hoffmann La Roche | Reduction of application-related side reaction of a therapeutic antibody. |
-
2019
- 2019-12-20 AR ARP190103792A patent/AR117468A1/en unknown
- 2019-12-20 AU AU2019406712A patent/AU2019406712A1/en active Pending
- 2019-12-20 BR BR112021012022A patent/BR112021012022A2/en unknown
- 2019-12-20 TW TW108146845A patent/TW202039552A/en unknown
- 2019-12-20 SG SG11202106198YA patent/SG11202106198YA/en unknown
- 2019-12-20 KR KR1020217020190A patent/KR102652720B1/en active IP Right Grant
- 2019-12-20 WO PCT/EP2019/086529 patent/WO2020127873A1/en active Application Filing
- 2019-12-20 US US16/722,317 patent/US11130804B2/en active Active
- 2019-12-20 EP EP19836489.5A patent/EP3898671A1/en active Pending
- 2019-12-20 JP JP2021535578A patent/JP7114813B2/en active Active
- 2019-12-20 CA CA3123503A patent/CA3123503A1/en active Pending
- 2019-12-20 KR KR1020247009946A patent/KR20240042566A/en active Search and Examination
- 2019-12-20 MX MX2021007421A patent/MX2021007421A/en unknown
- 2019-12-20 PE PE2021000884A patent/PE20211294A1/en unknown
- 2019-12-20 CN CN201980084480.5A patent/CN113195531A/en active Pending
- 2019-12-20 CR CR20210332A patent/CR20210332A/en unknown
-
2021
- 2021-05-27 ZA ZA2021/03643A patent/ZA202103643B/en unknown
- 2021-05-30 IL IL283566A patent/IL283566A/en unknown
- 2021-06-17 CL CL2021001616A patent/CL2021001616A1/en unknown
- 2021-07-01 CO CONC2021/0008755A patent/CO2021008755A2/en unknown
- 2021-09-08 US US17/469,044 patent/US11866490B2/en active Active
-
2022
- 2022-07-27 JP JP2022119854A patent/JP7342212B2/en active Active
-
2023
- 2023-08-30 JP JP2023139510A patent/JP2023162345A/en active Pending
- 2023-11-15 US US18/510,174 patent/US20240101657A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021012022A2 (en) | 2021-11-03 |
| CA3123503A1 (en) | 2020-06-25 |
| CL2021001616A1 (en) | 2022-01-14 |
| JP2022141933A (en) | 2022-09-29 |
| CN113195531A (en) | 2021-07-30 |
| KR20210099053A (en) | 2021-08-11 |
| JP7342212B2 (en) | 2023-09-11 |
| TW202039552A (en) | 2020-11-01 |
| JP7114813B2 (en) | 2022-08-08 |
| KR20240042566A (en) | 2024-04-02 |
| AR117468A1 (en) | 2021-08-11 |
| ZA202103643B (en) | 2022-09-28 |
| PE20211294A1 (en) | 2021-07-20 |
| US11130804B2 (en) | 2021-09-28 |
| IL283566A (en) | 2021-07-29 |
| CR20210332A (en) | 2021-09-09 |
| EP3898671A1 (en) | 2021-10-27 |
| JP2022508393A (en) | 2022-01-19 |
| MX2021007421A (en) | 2021-08-05 |
| WO2020127873A1 (en) | 2020-06-25 |
| US11866490B2 (en) | 2024-01-09 |
| CO2021008755A2 (en) | 2021-07-19 |
| AU2019406712A1 (en) | 2021-06-17 |
| US20220041707A1 (en) | 2022-02-10 |
| US20200199214A1 (en) | 2020-06-25 |
| KR102652720B1 (en) | 2024-03-29 |
| JP2023162345A (en) | 2023-11-08 |
| US20240101657A1 (en) | 2024-03-28 |
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