SG11201811408PA - Adoptive cell transfer and oncolytic virus combination therapy - Google Patents
Adoptive cell transfer and oncolytic virus combination therapyInfo
- Publication number
- SG11201811408PA SG11201811408PA SG11201811408PA SG11201811408PA SG11201811408PA SG 11201811408P A SG11201811408P A SG 11201811408PA SG 11201811408P A SG11201811408P A SG 11201811408PA SG 11201811408P A SG11201811408P A SG 11201811408PA SG 11201811408P A SG11201811408P A SG 11201811408PA
- Authority
- SG
- Singapore
- Prior art keywords
- hamilton
- ontario
- international
- street west
- main street
- Prior art date
Links
- 244000309459 oncolytic virus Species 0.000 title abstract 3
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 102220240796 rs553605556 Human genes 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- A—HUMAN NECESSITIES
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- A61K35/66—Microorganisms or materials therefrom
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- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2760/20011—Rhabdoviridae
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- C12N2760/20241—Use of virus, viral particle or viral elements as a vector
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- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1#11101111 0 11101 HOE 010 1111 1 0 013 OH 11111 3100110111110 1111 011 International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/219150 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: A61K 39/00 (2006.01) A61P 37/02 (2006.01) A61K 35/66 (2015.01) CO7K 16/28 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, A61K 35/768 (2015.01) Cl 2N 5/0783 (2010.01) A61P 35/00 (2006.01) Cl 2N 7/01 (2006.01) A61P 35/04 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (21) International Application Number: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, PCT/CA2017/050772 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 23 June 2017 (23.06.2017) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (26) Publication Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (30) Priority Data: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 62/354,506 24 June 2016 (24.06.2016) US MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (71) Applicant: MCMASTER UNIVERSITY [CA/CA]; 1280 KM, ML, MR, NE, SN, TD, TG). Main Street West, Hamilton, Ontario L8S 4K1 (CA). (72) Inventors: WAN, Yonghong; c/o McMaster University, Published: 1280 Main Street West, Hamilton, Ontario L8S 4K1 (CA). — with international search report (Art. 21(3)) — WALSH, Scott; c/o McMaster University, 1280 Main — with sequence listing part of description (Rule 5.2(a)) = Street West, Hamilton, Ontario L8S 4K1 (CA). CHEN, Lan; c/o McMaster University, 1280 Main Street West, =_ Hamilton, Ontario L8S 4K1 (CA). SALEM, Omar; c/o Mc- = Master University, 1280 Main Street West, Hamilton, On- = tario L8S 4K1 (CA). SIMOVIC, Boris; c/o McMaster Uni- = _ versity, 1280 Main Street West, Hamilton, Ontario L8S 4K1 = — (CA). Agent: NAUMAN, David et al.; Borden Ladner Gervais (74) LLP, World Exchange Plaza, 100 Queen Street, Suite 1300, Ottawa, Ontario KIP 1J9 (CA). = = = Designated States (unless otherwise indicated, for every = (81) kind of national protection available): AE, AG, AL, AM, = = Title: ADOPTIVE CELL TRANSFER AND ONCOLYTIC VIRUS COMBINATION THERAPY (54) = = FIGURE 5 = 40 n fidpi = 12dp1 8 90 + 1-1 20 1 l .4 U. 10 0 ki) R Il 0 01 / Il ei IN AcP ,0 ,f , ...tb 4 4 I , kc' N.b` 1-1 f's / 0 ei (57) : The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific ..) CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662354506P | 2016-06-24 | 2016-06-24 | |
PCT/CA2017/050772 WO2017219150A1 (en) | 2016-06-24 | 2017-06-23 | Adoptive cell transfer and oncolytic virus combination therapy |
Publications (1)
Publication Number | Publication Date |
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SG11201811408PA true SG11201811408PA (en) | 2019-01-30 |
Family
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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SG10201913600RA SG10201913600RA (en) | 2016-06-24 | 2017-06-23 | Adoptive cell transfer and oncolytic virus combination therapy |
SG11201811408PA SG11201811408PA (en) | 2016-06-24 | 2017-06-23 | Adoptive cell transfer and oncolytic virus combination therapy |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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SG10201913600RA SG10201913600RA (en) | 2016-06-24 | 2017-06-23 | Adoptive cell transfer and oncolytic virus combination therapy |
Country Status (8)
Country | Link |
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US (3) | US11045496B2 (en) |
EP (2) | EP4197551A3 (en) |
JP (1) | JP2019524667A (en) |
KR (1) | KR20190033066A (en) |
CN (2) | CN109310746B (en) |
CA (1) | CA3028813A1 (en) |
SG (2) | SG10201913600RA (en) |
WO (1) | WO2017219150A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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BR112020013848A2 (en) * | 2018-01-08 | 2020-12-01 | Iovance Biotherapeutics, Inc. | methods for expanding tumor-infiltrating lymphocytes and for treating an individual with cancer, tumor-infiltrating lymphocyte population, and, method for evaluating transcription factors |
US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
CN110305198B (en) * | 2018-03-27 | 2021-01-29 | 睿丰康生物医药科技(浙江)有限公司 | Oncolytic rhabdovirus attenuated strain and application thereof in tumor treatment |
JP7447011B2 (en) * | 2018-03-28 | 2024-03-11 | ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム | Use of histone modifiers to reprogram effector T cells |
EP3877511A1 (en) * | 2018-11-05 | 2021-09-15 | Iovance Biotherapeutics, Inc. | Expansion of tils utilizing akt pathway inhibitors |
CN111494414A (en) * | 2019-01-31 | 2020-08-07 | 惠君生物医药科技(杭州)有限公司 | Pharmaceutical composition for combined immunotherapy of cancer and application thereof |
GB201909144D0 (en) * | 2019-06-25 | 2019-08-07 | Autolus Ltd | Culture medium |
JP2022554217A (en) * | 2019-10-23 | 2022-12-28 | ザ・カウンシル・オヴ・ザ・クイーンズランド・インスティテュート・オヴ・メディカル・リサーチ | adoptive immunotherapy |
WO2023049860A1 (en) * | 2021-09-24 | 2023-03-30 | Oregon Health & Science University | Immune cells with reduced androgen receptor (ar) level, and methods of their use to enhance anti-cancer therapy |
WO2023088437A1 (en) * | 2021-11-19 | 2023-05-25 | 南开大学 | Recombinant armed oncolytic virus composition and use thereof in til adoptive therapy |
WO2023130040A2 (en) * | 2021-12-31 | 2023-07-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell therapy with vaccination as a combination immunotherapy against cancer |
Family Cites Families (8)
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PL1814580T3 (en) | 2004-11-24 | 2017-03-31 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
KR20080048455A (en) * | 2005-08-08 | 2008-06-02 | 폰다지오네 센트로 산 라파엘 델 몬테 테이보 | USE OF COMMON Gamma; CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES |
EP2064229B1 (en) | 2006-09-15 | 2015-08-12 | Ottawa Hospital Research Institute | Oncolytic rhabdovirus |
ES2576036T3 (en) * | 2009-03-16 | 2016-07-05 | Mcmaster University | Vaccination Methods |
CN102858959B (en) | 2009-12-10 | 2016-02-24 | 渥太华医院研究院 | Oncolytic rhabdovirus |
CA2848121C (en) * | 2011-09-08 | 2022-07-05 | Yeda Research And Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
CA2951222A1 (en) | 2014-06-05 | 2015-12-10 | Pontificia Universidad Catolica De Chile | Method for producing autologous tolerogenic dendritic cells (toldcs) with specific antigens and their use in the preparation of a medicament useful for the treatment of systemic lupus erythematosus (sle) |
EP3347473A4 (en) | 2015-09-09 | 2019-04-10 | Tvax Biomedical I, LLC | Methods for combining adoptive t cell therapy with oncolytic virus adjunct therapy |
-
2017
- 2017-06-23 WO PCT/CA2017/050772 patent/WO2017219150A1/en unknown
- 2017-06-23 CN CN201780038919.1A patent/CN109310746B/en active Active
- 2017-06-23 CA CA3028813A patent/CA3028813A1/en active Pending
- 2017-06-23 SG SG10201913600RA patent/SG10201913600RA/en unknown
- 2017-06-23 JP JP2018567182A patent/JP2019524667A/en active Pending
- 2017-06-23 CN CN202311501171.8A patent/CN117731763A/en active Pending
- 2017-06-23 SG SG11201811408PA patent/SG11201811408PA/en unknown
- 2017-06-23 US US16/312,897 patent/US11045496B2/en active Active
- 2017-06-23 EP EP22208589.6A patent/EP4197551A3/en active Pending
- 2017-06-23 KR KR1020197002322A patent/KR20190033066A/en unknown
- 2017-06-23 EP EP17814390.5A patent/EP3474888B1/en active Active
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2021
- 2021-05-20 US US17/325,557 patent/US20210338732A1/en not_active Abandoned
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2023
- 2023-11-01 US US18/499,857 patent/US20240058383A1/en active Pending
Also Published As
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US20240058383A1 (en) | 2024-02-22 |
KR20190033066A (en) | 2019-03-28 |
CN117731763A (en) | 2024-03-22 |
EP3474888A1 (en) | 2019-05-01 |
EP3474888A4 (en) | 2020-03-18 |
US20190321400A1 (en) | 2019-10-24 |
JP2019524667A (en) | 2019-09-05 |
WO2017219150A1 (en) | 2017-12-28 |
US20210338732A1 (en) | 2021-11-04 |
EP4197551A3 (en) | 2023-10-25 |
EP3474888B1 (en) | 2022-11-23 |
SG10201913600RA (en) | 2020-02-27 |
US11045496B2 (en) | 2021-06-29 |
CN109310746A (en) | 2019-02-05 |
EP4197551A2 (en) | 2023-06-21 |
CA3028813A1 (en) | 2017-12-28 |
CN109310746B (en) | 2023-12-05 |
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