SG11201809700YA - Gdf15 fusion proteins and uses thereof - Google Patents

Gdf15 fusion proteins and uses thereof

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Publication number
SG11201809700YA
SG11201809700YA SG11201809700YA SG11201809700YA SG11201809700YA SG 11201809700Y A SG11201809700Y A SG 11201809700YA SG 11201809700Y A SG11201809700Y A SG 11201809700YA SG 11201809700Y A SG11201809700Y A SG 11201809700YA SG 11201809700Y A SG11201809700Y A SG 11201809700YA
Authority
SG
Singapore
Prior art keywords
pennsylvania
international
fusion proteins
road
rule
Prior art date
Application number
SG11201809700YA
Inventor
Anthony Armstrong
Judith Ann Connor
Jennifer Furman
Chichi Huang
Michael J Hunger
Xiefan Lin-Schmidt
Serena Nelson
Shamina Rangwala
Shannon Mullican
Jose Antonio Chavez
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of SG11201809700YA publication Critical patent/SG11201809700YA/en

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    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
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    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
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    • C07K14/475—Growth factors; Growth regulators
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    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/196647 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: San Diego, California 92121 (US). HUANG, Chichi; 1400 A61K 9/00 (2006.01) CO 7K 14/00 (2006.01) McKean Road, Spring House, Pennsylvania 19477 (US). A61K 38/00 (2006.01) C07K 14/495 (2006.01) HUNGER, Michael J.; 3210 Merryfield Row, San Diego, A61K 38/18 (2006.01) C07K 14/765 (2006.01) California 92121 (US). LIN-SCHMIDT, Xiefan; 1400 (21) International Application Number: McKean Road, Spring House, Pennsylvania 19477 (US). NELSON, Serena; 3210 Merryfield Row, San Diego, Cal- PCT/US2017/031197 ifornia 92121 (US). RANGWALA, Shamina; 1400 McK- (22) International Filing Date: can Road, Spring House, Pennsylvania 19477 (US). MUL- 05 May 2017 (05.05.2017) LICAN, Shannon; 1400 McKean Road, Spring House, (25) Filing Language: English Pennsylvania 19477 (US). CHAVEZ, Jose Antonio; 1400 McKean Road, Spring House, Pennsylvania 19477 (US). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, 62/333,886 10 May 2016 (10.05.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (71) Applicant: JANSSEN BIOTECH, INC. [US/US]; DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, 800/850 Ridgeview Drive, Horsham, Pennsylvania 19044 HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (US). KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, — (72) Inventors: ARMSTRONG, Anthony; 1400 McKean MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, Road, Spring House, Pennsylvania 19477 (US). CONNOR, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, Judith Ann; 3210 Merryfield Row, San Diego, California SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 92121 (US). FURMAN, Jennifer; 3210 Merryfield Row, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = Title: GDF15 FUSION PROTEINS AND USES THEREOF (54) = Figure 1A = = = = = ‘s = gin AV - _ GDF15 = = = = _ _ = _ Il Ir ... ' 71' TG933 0\ 1-1 ---- (57) : Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described IN ,—I are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of 0 using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions. ei C [Continued on next page] WO 2017/196647 Al MIDEDIMOMOIDEIROIDEMOMOHEIRIEHOEUVOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))
SG11201809700YA 2016-05-10 2017-05-05 Gdf15 fusion proteins and uses thereof SG11201809700YA (en)

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Application Number Priority Date Filing Date Title
US201662333886P 2016-05-10 2016-05-10
PCT/US2017/031197 WO2017196647A1 (en) 2016-05-10 2017-05-05 Gdf15 fusion proteins and uses thereof

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KR (2) KR20230169417A (en)
CN (1) CN109451726A (en)
AR (1) AR108442A1 (en)
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