SG11201804711RA - Compounds and methods for kinase modulation, and indications therefor - Google Patents

Compounds and methods for kinase modulation, and indications therefor

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Publication number
SG11201804711RA
SG11201804711RA SG11201804711RA SG11201804711RA SG11201804711RA SG 11201804711R A SG11201804711R A SG 11201804711RA SG 11201804711R A SG11201804711R A SG 11201804711RA SG 11201804711R A SG11201804711R A SG 11201804711RA SG 11201804711R A SG11201804711R A SG 11201804711RA
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SG
Singapore
Prior art keywords
plexxikon
bolivar
suite
drive
berkeley
Prior art date
Application number
SG11201804711RA
Inventor
Guoxian Wu
Jeffrey Wu
Katrina Chan
Ken Dong
Todd Ewing
Prabha N Ibrahim
Jack Lin
Wayne Spevak
Ying Zhang
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Plexxikon Inc
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Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of SG11201804711RA publication Critical patent/SG11201804711RA/en

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau res., 00) (43) International Publication Date .... ..sr.) 15 June 2017(15.06.2017) WIPO I PCT ID Hit (10) WO 1111111111111111111111111111 International III 2017/100201 Publication IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII Al Number (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 471/04 (2006.01) A61P 35/00 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/437 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2016/065179 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 6 December 2016 (06.12.2016) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/264,180 7 December 2015 (07.12.2015) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: PLEXXIKON INC. [US/US]; 91 Bolivar GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Drive, Suite A, Berkeley, California 94710 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: WU, Guoxian; c/o Plexxikon Inc., 91 Bolivar TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Drive, Suite A, Berkeley, California 94710 (US). WU, Jef- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, frey; c/o Plexxikon Inc., 91 Bolivar Drive, Suite A, Berke- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, ley, California 94710 (US). CHAN, Katrina; c/o GW, KM, ML, MR, NE, SN, TD, TG). Plexxikon Inc., 91 Bolivar Drive, Suite A, Berkeley, Cali- fornia 94710 (US). DONG, Ken; c/o Plexxikon Inc., 91 Declarations under Rule 4.17: Bolivar Drive, Suite A, Berkeley, California 94710 (US). — EWING, Todd; Plexxikon Inc., 91 Bolivar Drive, as to the applicant's entitlement to claim the priority of the c/o earlier application (Rule 4.17 (iii)) Suite A, Berkeley, California 94710 (US). IBRAHIM, Prabha N.; c/o Plexxikon Inc., 91 Bolivar Drive, Suite A, Published: Berkeley, California 94710 (US). LIN, Jack; c/o with international search report (Art 21(3)) Plexxikon Inc., 91 Bolivar Drive, Suite A, Berkeley, Cali- fornia 94710 (US). SPEVAK, Wayne; c/o Plexxikon Inc., — before the expiration of the time limit for amending the Bolivar Drive, A, Berkeley, claims and to be republished in the event of receipt of 91 Suite California 94710 48.2(h)) (US). ZHANG, Ying; c/o Plexxikon Inc., 91 Bolivar amendments (Rule Drive, Suite A, Berkeley, California 94710 (US). (74) Agents: TANNER, Lorna L. et al.; Sheppard Mullin Richter & Hampton LLP, 379 Lytton Avenue, Palo Alto, California 94301-1479 (US). (54) Title: COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR — Z 3 Il \ Z2 ( I ) ' 4 t Il 0 el 0 0 Il IN 1-1 (57) : Disclosed are compounds 0 deuterated analog thereof, wherein Z 2 , Z and Z are as described herein, compositions thereof, and uses thereof 3 , ei of Foiinula I or 5 a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a O
SG11201804711RA 2015-12-07 2016-12-06 Compounds and methods for kinase modulation, and indications therefor SG11201804711RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562264180P 2015-12-07 2015-12-07
PCT/US2016/065179 WO2017100201A1 (en) 2015-12-07 2016-12-06 Compounds and methods for kinase modulation, and indications therefor

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US (1) US9938273B2 (en)
EP (1) EP3386980B1 (en)
JP (1) JP6862468B2 (en)
KR (1) KR20180086247A (en)
CN (1) CN108368110A (en)
AU (1) AU2016367147B2 (en)
BR (1) BR112018011475A2 (en)
CA (1) CA3007462C (en)
CO (1) CO2018007052A2 (en)
ES (1) ES2899581T3 (en)
IL (1) IL259803A (en)
MX (1) MX2018006856A (en)
PH (1) PH12018501179A1 (en)
RU (1) RU2018123825A (en)
SG (1) SG11201804711RA (en)
WO (1) WO2017100201A1 (en)

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