SG11201407458XA - TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS - Google Patents

TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

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Publication number
SG11201407458XA
SG11201407458XA SG11201407458XA SG11201407458XA SG11201407458XA SG 11201407458X A SG11201407458X A SG 11201407458XA SG 11201407458X A SG11201407458X A SG 11201407458XA SG 11201407458X A SG11201407458X A SG 11201407458XA SG 11201407458X A SG11201407458X A SG 11201407458XA
Authority
SG
Singapore
Prior art keywords
international
inhibitors
compounds
thane
mum
Prior art date
Application number
SG11201407458XA
Inventor
Laxmikant Atmaram Gharat
Nagarajan Muthukaman
Neelima Khairatkar-Joshi
Vidya Ganapati Kattige
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of SG11201407458XA publication Critical patent/SG11201407458XA/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/42—Oxazoles
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/186692 A1 (51) International Patent Classification: C07D 403/12 C07D 401/04 C07D C07D 403/04 C07D C07D 405/12 C07D 409/14 401/10 403/10 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01) C07D 417/12 (2006.01) C07D 249/12 (2006.01) A61K31/4196 (2006.01) A61P 29/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/054752 10 June 2013 (10.06.2013) English (30) Priority Data: 1733/MUM/2012 15 June 2012 (15.06.2012) 61/668,146 5 July 2012 (05.07.2012) 3 319/MUM/2012 19 November 2012(19.11.2012) 61/735,679 11 December 2012 (11.12.2012) 387/MUM/2013 February 8 2013 (08.02.2013) 61/792,225 15 March 2013 (15.03.2013) English IN US IN US IN IN (71) Applicant: GLENMARK PHARMACEUTICALS S.A. [CH/CH]; Chemin de la Combeta 5, CH-2300 La Chaux- de-Fonds (CH). (72) Inventors: GHARAT, Laxmikant Atmaram; Flat No-203 Tirupati Apartments, Pokhran road no - 2, Majiwada, Thane (West), Maharashtra 400601 (IN). MUTHUKA- MAN, Nagarajan; # 20, Malay Amman Kovil Street, Kodumudi, Erode, Tamil Nadu 638151 (IN). KHAIR- ATKAR-JOSHI, Neelima; 101, Devprayag CHS, Bhakti Mandir Rd, Hari Niwas, Panchpakhadi, Thane (W), Maha­ rashtra 400602 (IN). KATTIGE, Vidya Ganapati; 101, Eureka, Hiranandani Estate, Patlipada, Off Ghodbunder Road, Thane (W), Maharashtra 400607 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS CJ o\ 00 (I) —' A T-H o CJ (57) Abstract: The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mP - GES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are there­ fore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.
SG11201407458XA 2012-06-15 2013-06-10 TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS SG11201407458XA (en)

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IN387MU2013 2013-02-08
US201361792225P 2013-03-15 2013-03-15
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