SG11201803920TA - Compounds and compositions useful for treating disorders related to ntrk - Google Patents
Compounds and compositions useful for treating disorders related to ntrkInfo
- Publication number
- SG11201803920TA SG11201803920TA SG11201803920TA SG11201803920TA SG11201803920TA SG 11201803920T A SG11201803920T A SG 11201803920TA SG 11201803920T A SG11201803920T A SG 11201803920TA SG 11201803920T A SG11201803920T A SG 11201803920TA SG 11201803920T A SG11201803920T A SG 11201803920TA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- ntrk
- cambridge
- street
- pct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau (43) International Publication Date ..... .....r .,„01 26 May 2017(26.05.2017) WIPO I PCT ID Hit (10) WO International 2017/087778 111111111111111111IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIMIIIIIIIIIIIIIII Publication Al Number (51) International Patent Classification: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, C07D 487/04 (2006.01) A61K 31/519 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (21) International Application Number: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/US2016/062731 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 18 November 2016 (18.11.2016) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (25) Filing Language: English ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/257,476 19 November 2015 (19.11.2015) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: BLUEPRINT MEDICINES CORPORA- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, TION [US/US]; 38 Sidney Street, Suite 200, Cambridge, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MA 02139 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: WENGLOWSKY, Steven, Mark; 266 Har- GW, KM, ML, MR, NE, SN, TD, TG). yard Street, Apt 6, Cambridge, MA 02139 (US). MIDU- TURU, Chandrasekhar, V.; 348 Harvard Street, Apt. #2, Declarations under Rule 4.17: Cambridge, MA 02138 (US). BIFULCO, Neil, Jr; 15 Lil- as to applicant's entitlement to apply for and be granted a lian Ave, Sudbury, MA 01776 (US). KIM, Joseph, L.; 20 patent (Rule 4.170) Green Way, Wayland, MA 01778 (US). — as to the applicant's entitlement to claim the of the priority (74) Agent: MCCARTY, Catherine, M.; Lando & Anastasi, earlier application (Rule 4.17 (iii)) — LLP, Riverfront Office Park, One Main Street, Suite 1100, Cambridge, MA 02142 (US). Published: — with international search report (Art 21(3)) (81) Designated States (unless otherwise indicated, for every kind of national available): AE, AG, AL, AM, protection AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, Il .4t Ge IN IN IN Ge C::: , IN l'I C::: , N (54) Title: COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK P (57) : This invention relates to inhibitors of NTRK comprising a pyrazolo[1,5-4]pyrimidine-3-carbonitrile structure. They P. are active against wild-type NTRK and its resistant mutants.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562257476P | 2015-11-19 | 2015-11-19 | |
| PCT/US2016/062731 WO2017087778A1 (en) | 2015-11-19 | 2016-11-18 | Compounds and compositions useful for treating disorders related to ntrk |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201803920TA true SG11201803920TA (en) | 2018-06-28 |
Family
ID=57517997
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201912607SA SG10201912607SA (en) | 2015-11-19 | 2016-11-18 | Compounds and compositions useful for treating disorders related to ntrk |
| SG11201803920TA SG11201803920TA (en) | 2015-11-19 | 2016-11-18 | Compounds and compositions useful for treating disorders related to ntrk |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201912607SA SG10201912607SA (en) | 2015-11-19 | 2016-11-18 | Compounds and compositions useful for treating disorders related to ntrk |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10370379B2 (en) |
| EP (1) | EP3377497A1 (en) |
| JP (1) | JP2019500328A (en) |
| KR (1) | KR20180081790A (en) |
| CN (1) | CN108431008A (en) |
| AR (1) | AR106756A1 (en) |
| AU (1) | AU2016355196A1 (en) |
| BR (1) | BR112018010024A8 (en) |
| CA (1) | CA3005741A1 (en) |
| HK (1) | HK1259453A1 (en) |
| IL (1) | IL259164A (en) |
| MX (1) | MX2018006195A (en) |
| PH (1) | PH12018501065A1 (en) |
| RU (1) | RU2018122089A (en) |
| SG (2) | SG10201912607SA (en) |
| TW (1) | TWI733713B (en) |
| WO (1) | WO2017087778A1 (en) |
| ZA (1) | ZA201803530B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2916220T3 (en) | 2012-07-11 | 2022-06-29 | Blueprint Medicines Corp | Fibroblast growth factor receptor inhibitors |
| EP2970231A1 (en) | 2013-03-15 | 2016-01-20 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
| DK3057969T3 (en) | 2013-10-17 | 2018-09-24 | Blueprint Medicines Corp | COMPOSITIONS USED FOR TREATMENT OF DISEASES RELATED TO ENZYMETE KIT |
| ES2924111T3 (en) | 2013-10-25 | 2022-10-04 | Blueprint Medicines Corp | Fibroblast growth factor receptor inhibitors |
| US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| EP3325481B1 (en) | 2015-07-24 | 2019-06-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to kit and pdgfr |
| CN108137607B (en) | 2015-08-26 | 2021-04-06 | 缆图药品公司 | Compounds and compositions suitable for treating NTRK-related disorders |
| FI3371171T3 (en) | 2015-11-02 | 2024-01-10 | Blueprint Medicines Corp | Inhibitors of ret |
| SG10201912607SA (en) | 2015-11-19 | 2020-02-27 | Blueprint Medicines Corp | Compounds and compositions useful for treating disorders related to ntrk |
| UY37155A (en) | 2016-03-17 | 2017-10-31 | Blueprint Medicines Corp | RET INHIBITORS |
| CN109311889B (en) | 2016-04-15 | 2021-11-16 | 缆图药品公司 | Activin receptor-like kinase inhibitors |
| US10227329B2 (en) | 2016-07-22 | 2019-03-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
| WO2018183712A1 (en) | 2017-03-31 | 2018-10-04 | Blueprint Medicines Corporation | Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr |
| WO2019079649A1 (en) | 2017-10-18 | 2019-04-25 | Blueprint Medicines Corporation | Substituted pyrrolopyridines as inhibitors of activin receptor-like kinase |
| US20210100795A1 (en) | 2018-04-03 | 2021-04-08 | Blueprint Medicines Corporation | Ret inhibitor for use in treating cancer having a ret alteration |
| PE20212196A1 (en) | 2018-10-30 | 2021-11-16 | Kronos Bio Inc | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| PT3856341T (en) | 2019-04-12 | 2023-12-12 | Blueprint Medicines Corp | Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| CN112979654B (en) * | 2019-12-16 | 2024-03-19 | 赛诺哈勃药业（成都）有限公司 | Heteroaryl fused ring compounds, preparation method and application thereof |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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| US5251911A (en) | 1992-12-09 | 1993-10-12 | Blake Carlton E | Safety construction for passenger vehicle |
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| DE60332846D1 (en) | 2002-09-04 | 2010-07-15 | Pharmacopeia Llc | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISORDERS |
| US7329662B2 (en) * | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
| SG163576A1 (en) | 2004-04-02 | 2010-08-30 | Osi Pharm Inc | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
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| RU2015143517A (en) * | 2013-03-13 | 2017-04-19 | Дженентек, Инк. | Pyrazole-containing compounds and their use |
| EP2970231A1 (en) | 2013-03-15 | 2016-01-20 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
| GB2515785A (en) | 2013-07-03 | 2015-01-07 | Redx Pharma Ltd | Compounds |
| WO2015058129A1 (en) | 2013-10-17 | 2015-04-23 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| DK3057969T3 (en) | 2013-10-17 | 2018-09-24 | Blueprint Medicines Corp | COMPOSITIONS USED FOR TREATMENT OF DISEASES RELATED TO ENZYMETE KIT |
| ES2924111T3 (en) | 2013-10-25 | 2022-10-04 | Blueprint Medicines Corp | Fibroblast growth factor receptor inhibitors |
| WO2015108328A1 (en) * | 2014-01-14 | 2015-07-23 | 주식회사 엘지생명과학 | Novel ntrk1 fusion gene as colorectal cancer marker and use thereof |
| US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| JP6767875B2 (en) * | 2014-04-08 | 2020-10-14 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 2,3-Disubstituted pyridine compound as a TGF-beta inhibitor and how to use it |
| US9688680B2 (en) | 2014-08-04 | 2017-06-27 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| RU2708674C2 (en) | 2014-12-15 | 2019-12-11 | СиЭмДжи ФАРМАСЬЮТИКАЛ КО., ЛТД. | Condensed ring heteroaryl compounds and use thereof as trk inhibitors |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| US9981944B2 (en) | 2015-02-20 | 2018-05-29 | Rigel Pharmaceuticals, Inc | GDF-8 inhibitors |
| EP3325481B1 (en) | 2015-07-24 | 2019-06-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to kit and pdgfr |
| CN108137607B (en) | 2015-08-26 | 2021-04-06 | 缆图药品公司 | Compounds and compositions suitable for treating NTRK-related disorders |
| FI3371171T3 (en) | 2015-11-02 | 2024-01-10 | Blueprint Medicines Corp | Inhibitors of ret |
| SG10201912607SA (en) | 2015-11-19 | 2020-02-27 | Blueprint Medicines Corp | Compounds and compositions useful for treating disorders related to ntrk |
| UY37155A (en) | 2016-03-17 | 2017-10-31 | Blueprint Medicines Corp | RET INHIBITORS |
| CN109311889B (en) | 2016-04-15 | 2021-11-16 | 缆图药品公司 | Activin receptor-like kinase inhibitors |
| US10227329B2 (en) | 2016-07-22 | 2019-03-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
| CN110022900A (en) | 2016-09-08 | 2019-07-16 | 蓝图药品公司 | The combination of fibroblast growth factor receptor 4 inhibitor and cell cycle protein dependent kinase inhibitor |
| CN107844168B (en) | 2017-11-23 | 2020-12-01 | 英业达科技有限公司 | Mainboard assembly and fastening device thereof |
-
2016
- 2016-11-18 SG SG10201912607SA patent/SG10201912607SA/en unknown
- 2016-11-18 WO PCT/US2016/062731 patent/WO2017087778A1/en active Application Filing
- 2016-11-18 EP EP16808868.0A patent/EP3377497A1/en not_active Withdrawn
- 2016-11-18 BR BR112018010024A patent/BR112018010024A8/en not_active IP Right Cessation
- 2016-11-18 MX MX2018006195A patent/MX2018006195A/en unknown
- 2016-11-18 AU AU2016355196A patent/AU2016355196A1/en not_active Abandoned
- 2016-11-18 US US15/355,425 patent/US10370379B2/en active Active
- 2016-11-18 CN CN201680077637.8A patent/CN108431008A/en active Pending
- 2016-11-18 CA CA3005741A patent/CA3005741A1/en not_active Abandoned
- 2016-11-18 SG SG11201803920TA patent/SG11201803920TA/en unknown
- 2016-11-18 KR KR1020187016321A patent/KR20180081790A/en unknown
- 2016-11-18 RU RU2018122089A patent/RU2018122089A/en not_active Application Discontinuation
- 2016-11-18 JP JP2018525688A patent/JP2019500328A/en not_active Ceased
- 2016-11-18 AR ARP160103546A patent/AR106756A1/en unknown
- 2016-11-18 TW TW105137936A patent/TWI733713B/en not_active IP Right Cessation
-
2018
- 2018-05-06 IL IL259164A patent/IL259164A/en unknown
- 2018-05-17 PH PH12018501065A patent/PH12018501065A1/en unknown
- 2018-05-28 ZA ZA2018/03530A patent/ZA201803530B/en unknown
-
2019
- 2019-02-01 HK HK19101858.8A patent/HK1259453A1/en unknown
- 2019-07-31 US US16/527,773 patent/US11059827B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AR106756A1 (en) | 2018-02-14 |
| US20170145018A1 (en) | 2017-05-25 |
| BR112018010024A8 (en) | 2019-02-26 |
| HK1259453A1 (en) | 2019-11-29 |
| IL259164A (en) | 2018-06-28 |
| AU2016355196A1 (en) | 2018-06-21 |
| BR112018010024A2 (en) | 2018-11-21 |
| US11059827B2 (en) | 2021-07-13 |
| US10370379B2 (en) | 2019-08-06 |
| CA3005741A1 (en) | 2017-05-26 |
| PH12018501065A1 (en) | 2019-01-28 |
| RU2018122089A (en) | 2019-12-25 |
| ZA201803530B (en) | 2021-08-25 |
| KR20180081790A (en) | 2018-07-17 |
| JP2019500328A (en) | 2019-01-10 |
| WO2017087778A1 (en) | 2017-05-26 |
| MX2018006195A (en) | 2018-09-05 |
| US20190382410A1 (en) | 2019-12-19 |
| TWI733713B (en) | 2021-07-21 |
| CN108431008A (en) | 2018-08-21 |
| RU2018122089A3 (en) | 2019-12-30 |
| EP3377497A1 (en) | 2018-09-26 |
| TW201720826A (en) | 2017-06-16 |
| SG10201912607SA (en) | 2020-02-27 |
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