SG10201911069WA - High-throughput nucleotide library sequencing - Google Patents
High-throughput nucleotide library sequencingInfo
- Publication number
- SG10201911069WA SG10201911069WA SG10201911069WA SG10201911069WA SG10201911069WA SG 10201911069W A SG10201911069W A SG 10201911069WA SG 10201911069W A SG10201911069W A SG 10201911069WA SG 10201911069W A SG10201911069W A SG 10201911069WA SG 10201911069W A SG10201911069W A SG 10201911069WA
- Authority
- SG
- Singapore
- Prior art keywords
- library sequencing
- nucleotide library
- throughput
- throughput nucleotide
- sequencing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/179—Modifications characterised by incorporating arbitrary or random nucleotide sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
- C12Q2565/514—Detection characterised by immobilisation to a surface characterised by the use of the arrayed oligonucleotides as identifier tags, e.g. universal addressable array, anti-tag or tag complement array
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462050549P | 2014-09-15 | 2014-09-15 | |
US201462051832P | 2014-09-17 | 2014-09-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201911069WA true SG10201911069WA (en) | 2020-01-30 |
Family
ID=54291588
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201911069WA SG10201911069WA (en) | 2014-09-15 | 2015-09-15 | High-throughput nucleotide library sequencing |
SG11201702060VA SG11201702060VA (en) | 2014-09-15 | 2015-09-15 | High-throughput nucleotide library sequencing |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201702060VA SG11201702060VA (en) | 2014-09-15 | 2015-09-15 | High-throughput nucleotide library sequencing |
Country Status (13)
Country | Link |
---|---|
US (3) | US10590483B2 (en) |
EP (3) | EP3950944A1 (en) |
JP (3) | JP6672310B2 (en) |
KR (1) | KR102541849B1 (en) |
CN (1) | CN107002076B (en) |
AU (2) | AU2015318011B2 (en) |
CA (1) | CA2961210A1 (en) |
ES (2) | ES2895750T3 (en) |
IL (1) | IL251123B (en) |
MX (1) | MX2017003382A (en) |
SG (2) | SG10201911069WA (en) |
WO (1) | WO2016044227A1 (en) |
ZA (1) | ZA201701916B (en) |
Families Citing this family (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8691509B2 (en) | 2009-04-02 | 2014-04-08 | Fluidigm Corporation | Multi-primer amplification method for barcoding of target nucleic acids |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
CN104364392B (en) | 2012-02-27 | 2018-05-25 | 赛卢拉研究公司 | For the composition and kit of numerator counts |
IN2015DN01126A (en) | 2012-08-14 | 2015-06-26 | 10X Genomics Inc | |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
CA2894694C (en) | 2012-12-14 | 2023-04-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
DK2954065T3 (en) | 2013-02-08 | 2021-09-06 | 10X Genomics Inc | Division and processing of analytes and other species |
GB2584364A (en) | 2013-03-15 | 2020-12-02 | Abvitro Llc | Single cell bar-coding for antibody discovery |
KR20230074639A (en) | 2013-08-28 | 2023-05-30 | 벡톤 디킨슨 앤드 컴퍼니 | Massively parallel single cell analysis |
CN114534806B (en) | 2014-04-10 | 2024-03-29 | 10X基因组学有限公司 | Fluidic devices, systems and methods for packaging and partitioning reagents and uses thereof |
WO2015188839A2 (en) | 2014-06-13 | 2015-12-17 | Immudex Aps | General detection and isolation of specific cells by binding of labeled molecules |
KR20230070325A (en) | 2014-06-26 | 2023-05-22 | 10엑스 제노믹스, 인크. | Methods of analyzing nucleic acids from individual cells or cell populations |
MX2017003382A (en) | 2014-09-15 | 2017-11-20 | Abvitro Llc | High-throughput nucleotide library sequencing. |
CN107002128A (en) | 2014-10-29 | 2017-08-01 | 10X 基因组学有限公司 | The method and composition being sequenced for target nucleic acid |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
DE102014017085A1 (en) | 2014-11-20 | 2016-05-25 | Kautex Textron Gmbh & Co. Kg | Device for producing a reinforcing structure on a shaped body surface |
BR112017014902A2 (en) | 2015-01-12 | 2018-03-13 | 10X Genomics Inc | processes and systems for the preparation of nucleic acid sequencing libraries and libraries prepared using them |
WO2016137973A1 (en) | 2015-02-24 | 2016-09-01 | 10X Genomics Inc | Partition processing methods and systems |
WO2016138148A1 (en) | 2015-02-24 | 2016-09-01 | 10X Genomics, Inc. | Methods for targeted nucleic acid sequence coverage |
ES2836802T3 (en) | 2015-02-27 | 2021-06-28 | Becton Dickinson Co | Spatially addressable molecular barcodes |
EP4180535A1 (en) | 2015-03-30 | 2023-05-17 | Becton, Dickinson and Company | Methods and compositions for combinatorial barcoding |
US10788452B2 (en) * | 2015-04-21 | 2020-09-29 | General Automation Lab Technologies Inc. | High resolution systems, kits, apparatus, and methods for bacterial community relationship determination and other high throughput microbiology applications |
AU2016250591B2 (en) | 2015-04-21 | 2021-08-05 | Isolation Bio Inc. | High resolution systems, kits, apparatus, and methods for high throughput microbiology applications |
WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
JP6894380B2 (en) | 2015-04-27 | 2021-06-30 | アブビトロ, エルエルシー | Methods for Sequencing, Determining, Pairing and Verifying Therapeutic Drugs and Disease-Specific Antigens |
ES2745694T3 (en) | 2015-09-11 | 2020-03-03 | Cellular Res Inc | Methods and compositions for nucleic acid library normalization |
CN108289954B (en) | 2015-09-24 | 2022-05-31 | 阿布维特罗有限责任公司 | HIV antibody compositions and methods of use |
BR112018005937A2 (en) | 2015-09-24 | 2019-05-21 | Abvitro Llc | affinity oligonucleotide conjugates and uses of these |
KR20180097536A (en) * | 2015-11-04 | 2018-08-31 | 아트레카, 인크. | A combination set of nucleic acid barcodes for the analysis of nucleic acids associated with single cells |
SG11201804086VA (en) | 2015-12-04 | 2018-06-28 | 10X Genomics Inc | Methods and compositions for nucleic acid analysis |
EP4299136A3 (en) | 2015-12-16 | 2024-02-14 | Gritstone bio, Inc. | Neoantigen identification, manufacture, and use |
US11117113B2 (en) | 2015-12-16 | 2021-09-14 | Fluidigm Corporation | High-level multiplex amplification |
WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
SG11201811048UA (en) * | 2016-07-14 | 2019-01-30 | Fluidigm Corp | Single-cell transcript sequencing |
US10683531B2 (en) | 2016-09-15 | 2020-06-16 | ArcherDX, Inc. | Methods of nucleic acid sample preparation for analysis of cell-free DNA |
CN109937254B (en) | 2016-09-15 | 2023-05-30 | 阿谢尔德克斯有限责任公司 | Nucleic acid sample preparation method |
JP6929354B2 (en) * | 2016-09-24 | 2021-09-01 | アブビトロ, エルエルシー | Affinity-oligonucleotide conjugates and their use |
JP7091348B2 (en) | 2016-09-26 | 2022-06-27 | ベクトン・ディキンソン・アンド・カンパニー | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
US11072660B2 (en) | 2016-10-03 | 2021-07-27 | Juno Therapeutics, Inc. | HPV-specific binding molecules |
WO2018075693A1 (en) * | 2016-10-19 | 2018-04-26 | 10X Genomics, Inc. | Methods and systems for barcoding nucleic acid molecules from individual cells or cell populations |
CA3042391A1 (en) | 2016-11-02 | 2018-05-11 | ArcherDX, Inc. | Methods of nucleic acid sample preparation for immune repertoire sequencing |
US20190316180A1 (en) * | 2016-11-23 | 2019-10-17 | Universite De Strasbourg | Tandem barcoding of target molecules for their absolute quantification at single-entity resolution |
US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
MY201744A (en) | 2016-12-23 | 2024-03-15 | Visterra Inc | Binding polypeptides and methods of making the same |
EP3545089B1 (en) | 2017-01-30 | 2022-03-09 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
WO2018144240A1 (en) | 2017-02-01 | 2018-08-09 | Cellular Research, Inc. | Selective amplification using blocking oligonucleotides |
CN110199022A (en) * | 2017-02-16 | 2019-09-03 | 宝生物工程(美国) 有限公司 | Prepare the method for nucleic acid library and composition and kit for implementing the method |
WO2018208133A1 (en) * | 2017-05-12 | 2018-11-15 | 서울대학교산학협력단 | Method and apparatus for acquiring high-purity nucleotides |
CN116064732A (en) | 2017-05-26 | 2023-05-05 | 10X基因组学有限公司 | Single cell analysis of transposase accessibility chromatin |
AU2018273999A1 (en) | 2017-05-26 | 2019-12-05 | Abvitro Llc | High-throughput polynucleotide library sequencing and transcriptome analysis |
US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
WO2018226293A1 (en) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Sample indexing for single cells |
WO2019010486A1 (en) * | 2017-07-07 | 2019-01-10 | Board Of Regents, The University Of Texas System | High-coverage and ultra-accurate immune repertoire sequencing using molecular identifiers |
MX2020001491A (en) | 2017-08-09 | 2020-08-06 | Juno Therapeutics Inc | Methods and compositions for preparing genetically engineered cells. |
EP3679370A1 (en) | 2017-09-07 | 2020-07-15 | Juno Therapeutics, Inc. | Methods of identifying cellular attributes related to outcomes associated with cell therapy |
JP2020537515A (en) | 2017-10-03 | 2020-12-24 | ジュノー セラピューティクス インコーポレイテッド | HPV-specific binding molecule |
AU2018348165A1 (en) | 2017-10-10 | 2020-05-21 | Gritstone Bio, Inc. | Neoantigen identification using hotspots |
CN111051523B (en) | 2017-11-15 | 2024-03-19 | 10X基因组学有限公司 | Functionalized gel beads |
US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
EP3714275A4 (en) | 2017-11-22 | 2021-10-27 | Gritstone bio, Inc. | Reducing junction epitope presentation for neoantigens |
EP3717661A1 (en) | 2017-11-27 | 2020-10-07 | The Trustees of Columbia University in the City of New York | Rna printing and sequencing devices, methods, and systems |
CN111699042A (en) | 2017-12-07 | 2020-09-22 | 麻省理工学院 | Single cell analysis |
JP2021506260A (en) | 2017-12-15 | 2021-02-22 | ジュノー セラピューティクス インコーポレイテッド | Anti-CCT5 binding molecule and how to use it |
EP3728636A1 (en) * | 2017-12-19 | 2020-10-28 | Becton, Dickinson and Company | Particles associated with oligonucleotides |
CN108866174B (en) * | 2017-12-25 | 2023-05-19 | 厦门基源医疗科技有限公司 | Method for detecting low-frequency mutation of circulating tumor DNA |
CN108085341A (en) * | 2017-12-28 | 2018-05-29 | 河南省华隆生物技术有限公司 | A kind of MSGV recombinant vectors and its preparation method and application |
CN112236518A (en) * | 2018-02-23 | 2021-01-15 | 耶鲁大学 | Single cell freeze-thaw lysis |
CN112566698A (en) | 2018-04-05 | 2021-03-26 | 朱诺治疗学股份有限公司 | T cell receptor and engineered cells expressing the same |
CN112262218A (en) | 2018-04-06 | 2021-01-22 | 10X基因组学有限公司 | System and method for quality control in single cell processing |
WO2019213294A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
US11365409B2 (en) | 2018-05-03 | 2022-06-21 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
CN109251961A (en) * | 2018-06-28 | 2019-01-22 | 广西医科大学 | A kind of method of unicellular sequencing detection activating T cell |
CN112673100A (en) * | 2018-07-09 | 2021-04-16 | 格罗生物科学公司 | Compositions comprising non-standard amino acids and uses thereof |
KR102543325B1 (en) * | 2018-08-13 | 2023-06-13 | 루트패스 제노믹스, 인크. | High-throughput cloning of paired binary immunoreceptor polynucleotides and their applications |
WO2020046833A1 (en) * | 2018-08-28 | 2020-03-05 | Cellular Research, Inc. | Sample multiplexing using carbohydrate-binding and membrane-permeable reagents |
WO2020072380A1 (en) * | 2018-10-01 | 2020-04-09 | Cellular Research, Inc. | Determining 5' transcript sequences |
WO2020097315A1 (en) | 2018-11-08 | 2020-05-14 | Cellular Research, Inc. | Whole transcriptome analysis of single cells using random priming |
CN113195717A (en) | 2018-12-13 | 2021-07-30 | 贝克顿迪金森公司 | Selective extension in single cell whole transcriptome analysis |
WO2020154247A1 (en) | 2019-01-23 | 2020-07-30 | Cellular Research, Inc. | Oligonucleotides associated with antibodies |
PE20212198A1 (en) | 2019-01-29 | 2021-11-16 | Juno Therapeutics Inc | ANTIBODIES AND CHIMERIC RECEPTORS OF SPECIFIC ANTIGENS TO ORPHAN RECEPTOR 1, RECEPTOR TYROSINE KINASE TYPE (ROR1) |
WO2020206238A2 (en) | 2019-04-05 | 2020-10-08 | Rootpath Genomics, Inc. | Compositions and methods for t-cell receptor gene assembly |
US11965208B2 (en) | 2019-04-19 | 2024-04-23 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
CN110241460A (en) * | 2019-05-31 | 2019-09-17 | 南方医科大学南方医院 | A kind of immune group library method for screening the reaction of independent sample crossover |
CN110241459A (en) * | 2019-05-31 | 2019-09-17 | 南方医科大学南方医院 | A kind of immune group library method screening sample room and being reacted with independent sample crossover |
EP4004231A1 (en) | 2019-07-22 | 2022-06-01 | Becton, Dickinson and Company | Single cell chromatin immunoprecipitation sequencing assay |
WO2021023853A1 (en) * | 2019-08-08 | 2021-02-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Rna sequencing method for the analysis of b and t cell transcriptome in phenotypically defined b and t cell subsets |
WO2021092386A1 (en) | 2019-11-08 | 2021-05-14 | Becton Dickinson And Company | Using random priming to obtain full-length v(d)j information for immune repertoire sequencing |
EP4090763A1 (en) | 2020-01-13 | 2022-11-23 | Becton Dickinson and Company | Methods and compositions for quantitation of proteins and rna |
KR20230024283A (en) | 2020-05-13 | 2023-02-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | Methods for identifying features associated with clinical response and uses thereof |
US11661625B2 (en) | 2020-05-14 | 2023-05-30 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
WO2022081643A2 (en) * | 2020-10-13 | 2022-04-21 | 10X Genomics, Inc. | Compositions and methods for generating recombinant antigen binding molecules from single cells |
CN112071366B (en) * | 2020-10-13 | 2024-02-27 | 南开大学 | Metagenome data analysis method based on second-generation sequencing technology |
US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
CN114958996B (en) * | 2021-05-12 | 2022-12-20 | 浙江大学 | Ultrahigh-throughput unicellular sequencing reagent combination |
EP4355914A1 (en) * | 2021-06-18 | 2024-04-24 | Adoc Ssf, Llc | Methods for improved t cell receptor sequencing |
CN115029341A (en) * | 2022-05-23 | 2022-09-09 | 立凌生物制药(苏州)有限公司 | Rapid clone pairing TCR sequence detection method and application thereof |
WO2024015862A1 (en) * | 2022-07-13 | 2024-01-18 | 10X Genomics, Inc. | Methods for characterization of antigen-binding molecules from biological samples |
Family Cites Families (194)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4766067A (en) | 1985-05-31 | 1988-08-23 | President And Fellows Of Harvard College | Gene amplification |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
US4921794A (en) | 1987-01-14 | 1990-05-01 | President And Fellows Of Harvard College | T7 DNA polymerase |
US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
US5168038A (en) | 1988-06-17 | 1992-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | In situ transcription in cells and tissues |
US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
US5066584A (en) | 1988-09-23 | 1991-11-19 | Cetus Corporation | Methods for generating single stranded dna by the polymerase chain reaction |
US5091310A (en) | 1988-09-23 | 1992-02-25 | Cetus Corporation | Structure-independent dna amplification by the polymerase chain reaction |
US5142033A (en) | 1988-09-23 | 1992-08-25 | Hoffmann-La Roche Inc. | Structure-independent DNA amplification by the polymerase chain reaction |
US4994370A (en) | 1989-01-03 | 1991-02-19 | The United States Of America As Represented By The Department Of Health And Human Services | DNA amplification technique |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
US5252743A (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
AU660306B2 (en) | 1991-02-12 | 1995-06-22 | Roussel-Uclaf | Nucleotidic sequences coding for variable regions of beta chains of human T lymphocyte receptors, corresponding peptidic segments and diagnostic and therapeutic applications |
CA2124087C (en) | 1991-11-22 | 2002-10-01 | James L. Winkler | Combinatorial strategies for polymer synthesis |
US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
US5550215A (en) | 1991-11-22 | 1996-08-27 | Holmes; Christopher P. | Polymer reversal on solid surfaces |
CA2122732C (en) | 1991-11-25 | 2008-04-08 | Marc D. Whitlow | Multivalent antigen-binding proteins |
EP0746609A4 (en) | 1991-12-17 | 1997-12-17 | Genpharm Int | Transgenic non-human animals capable of producing heterologous antibodies |
US5491074A (en) | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
EP0705271B1 (en) | 1993-06-25 | 2002-11-13 | Affymetrix, Inc. (a Delaware Corporation) | Hybridization and sequencing of nucleic acids |
US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
US6090555A (en) | 1997-12-11 | 2000-07-18 | Affymetrix, Inc. | Scanned image alignment systems and methods |
US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
WO1995030774A1 (en) | 1994-05-05 | 1995-11-16 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
US5968740A (en) | 1995-07-24 | 1999-10-19 | Affymetrix, Inc. | Method of Identifying a Base in a Nucleic Acid |
US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
EP0902885A4 (en) | 1996-05-16 | 2006-09-27 | Affymetrix Inc | Systems and methods for detection of labeled materials |
WO1997045559A1 (en) | 1996-05-29 | 1997-12-04 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
PT1179600E (en) | 1996-06-04 | 2005-08-31 | Univ Utah Res Found | HIBRIDATION MONITORING DURING CPR |
PT937251E (en) | 1996-09-06 | 2007-01-31 | Ortho Mcneil Pharm Inc | Purification of antigen-specific t cells |
ATE545710T1 (en) | 1997-04-01 | 2012-03-15 | Illumina Cambridge Ltd | METHOD FOR THE DUPLICATION OF NUCLEIC ACIDS |
US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
WO1999023254A1 (en) | 1997-10-31 | 1999-05-14 | Affymetrix, Inc. | Expression profiles in adult and fetal organs |
US6269846B1 (en) | 1998-01-13 | 2001-08-07 | Genetic Microsystems, Inc. | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays |
US6428752B1 (en) | 1998-05-14 | 2002-08-06 | Affymetrix, Inc. | Cleaning deposit devices that form microarrays and the like |
US6054276A (en) | 1998-02-23 | 2000-04-25 | Macevicz; Stephen C. | DNA restriction site mapping |
US5936324A (en) | 1998-03-30 | 1999-08-10 | Genetic Microsystems Inc. | Moving magnet scanner |
DE69933369D1 (en) | 1998-04-03 | 2006-11-09 | Compound Therapeutics Inc | Adressierbare protein arrays |
JP3813818B2 (en) | 1998-05-01 | 2006-08-23 | アリゾナ ボード オブ リージェンツ | Method for determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
CA2366459A1 (en) | 1999-03-26 | 2000-10-05 | Affymetrix, Inc. | Universal arrays |
US6300070B1 (en) | 1999-06-04 | 2001-10-09 | Mosaic Technologies, Inc. | Solid phase methods for amplifying multiple nucleic acids |
GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
JP5508654B2 (en) | 2000-04-14 | 2014-06-04 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | Method for designing positionable arrays for detection of nucleic acid sequence differences using ligase detection reactions |
US6686184B1 (en) | 2000-05-25 | 2004-02-03 | President And Fellows Of Harvard College | Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks |
US7567870B1 (en) | 2000-07-31 | 2009-07-28 | Institute For Systems Biology | Multiparameter analysis for predictive medicine |
AU1092602A (en) | 2000-10-24 | 2002-05-06 | New Ind Res Organization | Genomes participating in rheumatoid arthritis, method of the diagnosis thereof, method of evaluating the onset possibility thereof, diagnostic kit for detectingthem and therapeutic method and remedies for rheumatoid arthritis |
US7393656B2 (en) | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
US7414111B2 (en) | 2001-09-19 | 2008-08-19 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
GB0127564D0 (en) | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
JP2006507921A (en) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Method and apparatus for fluid dispersion |
AU2003247129A1 (en) | 2002-07-01 | 2004-01-19 | Centre National De La Recherche Scientifique (Cnrs) | System, method, device, and computer program product for extraction, gathering, manipulation, and analysis of peak data from an automated sequencer |
EP1517995A4 (en) | 2002-07-03 | 2007-07-11 | Inst Scient Res Inc | Compositions and methods for the detection of human t cell receptor variable family gene expression |
AU2003283976B2 (en) | 2002-09-27 | 2009-12-10 | Cold Spring Harbor Laboratory | Cell-based RNA interference and related methods and compositions |
DK1549764T3 (en) | 2002-10-11 | 2011-01-24 | Univ Erasmus | Primers for nucleic acid amplification in PCR-based clonality studies |
EP2159285B1 (en) | 2003-01-29 | 2012-09-26 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
AU2004229440B2 (en) | 2003-04-10 | 2010-08-12 | President And Fellows Of Harvard College | Formation and control of fluidic species |
AU2003902299A0 (en) | 2003-05-13 | 2003-05-29 | Flinders Medical Centre | A method of analysing a marker nucleic acid molecule |
WO2005010145A2 (en) | 2003-07-05 | 2005-02-03 | The Johns Hopkins University | Method and compositions for detection and enumeration of genetic variations |
US7767435B2 (en) | 2003-08-25 | 2010-08-03 | University Of Washington | Method and device for biochemical detection and analysis of subcellular compartments from a single cell |
JP4630870B2 (en) | 2003-08-27 | 2011-02-09 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | Electronic control of fluid species |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
FR2863274B1 (en) | 2003-12-05 | 2012-11-16 | Commissariat Energie Atomique | METHOD FOR QUANTITATIVE EVALUATION OF REARRANGEMENT OR TARGETED GENETIC RECOMBINATION OF AN INDIVIDUAL AND APPLICATIONS THEREOF |
EP1704251A1 (en) | 2003-12-15 | 2006-09-27 | Institut Pasteur | Repertoire determination of a lymphocyte b population |
US20080166718A1 (en) | 2003-12-15 | 2008-07-10 | Institut Pasteur | Repertoire determination of a lymphocyte B population |
US20060046258A1 (en) | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
WO2005084134A2 (en) * | 2004-03-04 | 2005-09-15 | Dena Leshkowitz | Quantifying and profiling antibody and t cell receptor gene expression |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
US7622281B2 (en) | 2004-05-20 | 2009-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for clonal amplification of nucleic acid |
US7820382B2 (en) | 2004-08-03 | 2010-10-26 | Bauer A Robert | Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation |
US20080280282A1 (en) | 2004-08-03 | 2008-11-13 | Bauer Jr A Robert | Method for early detection of various cancers and gastrointestinal disease and monitoring of transplanted organs |
US20060094018A1 (en) | 2004-08-03 | 2006-05-04 | Bauer A R Jr | Discovery and a method for the early detection of pancreatic cancer and other disease conditions |
WO2006031221A1 (en) | 2004-09-13 | 2006-03-23 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Compositions comprising t cell receptors and methods of use thereof |
US7643818B2 (en) | 2004-11-22 | 2010-01-05 | Seven Networks, Inc. | E-mail messaging to/from a mobile terminal |
US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
WO2006096571A2 (en) | 2005-03-04 | 2006-09-14 | President And Fellows Of Harvard College | Method and apparatus for forming multiple emulsions |
EP2485052B1 (en) | 2005-09-13 | 2015-05-06 | Affymetrix, Inc. | Encoded microparticles |
US9360526B2 (en) | 2005-10-24 | 2016-06-07 | The Johns Hopkins University | Methods for beaming |
US7375211B2 (en) | 2005-11-18 | 2008-05-20 | Kou Zhong C | Method for detection and quantification of T-cell receptor Vβ repertoire |
US20070161031A1 (en) | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
WO2007081387A1 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices, methods of use, and kits for performing diagnostics |
WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
CA2640024A1 (en) | 2006-01-27 | 2007-08-09 | President And Fellows Of Harvard College | Fluidic droplet coalescence |
MX2008011280A (en) | 2006-03-06 | 2008-09-12 | Symphogen As | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections. |
WO2007133710A2 (en) | 2006-05-11 | 2007-11-22 | Raindance Technologies, Inc. | Microfluidic devices and methods of use thereof |
CA2656022C (en) | 2006-06-19 | 2017-10-17 | The Johns Hopkins University | Single-molecule pcr on microparticles in water-in-oil emulsions |
US20080108804A1 (en) | 2006-11-02 | 2008-05-08 | Kabushiki Kaisha Dnaform | Method for modifying RNAS and preparing DNAS from RNAS |
WO2008066596A2 (en) | 2006-11-30 | 2008-06-05 | Johns Hopkins University | Gene expression barcode for normal and diseased tissue classification |
WO2008076842A2 (en) | 2006-12-14 | 2008-06-26 | Applied Biosystems Inc. | Sequencing methods |
US20080269068A1 (en) | 2007-02-06 | 2008-10-30 | President And Fellows Of Harvard College | Multiplex decoding of sequence tags in barcodes |
EP2173509A4 (en) | 2007-06-25 | 2013-11-06 | Affymetrix Inc | Patterned microcodes |
CA2691940C (en) | 2007-07-03 | 2018-03-06 | Joost Alexander Kolkman | Methods for providing improved immunoglobulin sequences |
EP2036989B1 (en) | 2007-09-12 | 2012-07-25 | Institut Pasteur | Polynucleotide suitable for single cell based reporter assay to monitor gene expression patterns with high spatio-temporal resolution |
US8268564B2 (en) | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
WO2009045898A2 (en) | 2007-09-28 | 2009-04-09 | Mayo Foundation For Medical Education And Research | Assessing t cell repertoires |
EP2062982A1 (en) | 2007-11-26 | 2009-05-27 | ImmunID | Method for studying the V(D)J combinatorial diversity. |
US20110008775A1 (en) | 2007-12-10 | 2011-01-13 | Xiaolian Gao | Sequencing of nucleic acids |
US20090163366A1 (en) | 2007-12-24 | 2009-06-25 | Helicos Biosciences Corporation | Two-primer sequencing for high-throughput expression analysis |
EP2100970B1 (en) | 2008-03-13 | 2017-05-10 | National Institute of Immunology | Ig genes specific oligonucleotides and uses thereof |
US9012148B2 (en) | 2008-04-16 | 2015-04-21 | Jian Han | Method for evaluating and comparing immunorepertoires |
EP2644709B1 (en) | 2008-04-30 | 2014-12-17 | Integrated Dna Technologies, Inc. | RNase-H-based assays utilizing modified RNA monomers |
US8911948B2 (en) | 2008-04-30 | 2014-12-16 | Integrated Dna Technologies, Inc. | RNase H-based assays utilizing modified RNA monomers |
WO2010003132A1 (en) | 2008-07-02 | 2010-01-07 | Illumina Cambridge Ltd. | Using populations of beads for the fabrication of arrays on surfaces |
WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
US20100062494A1 (en) | 2008-08-08 | 2010-03-11 | President And Fellows Of Harvard College | Enzymatic oligonucleotide pre-adenylation |
WO2010021936A1 (en) | 2008-08-16 | 2010-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Digital pcr calibration for high throughput sequencing |
AU2009297108B2 (en) | 2008-09-23 | 2015-02-12 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
US9115399B2 (en) | 2008-09-23 | 2015-08-25 | The Trustees Of The University Of Pennsylvania | Recombination sequence (RS) rearrangement frequency as a measure of central B cell tolerance |
CN102227440A (en) | 2008-09-30 | 2011-10-26 | 雅培制药有限公司 | Improved antibody libraries |
EP2719774B8 (en) | 2008-11-07 | 2020-04-22 | Adaptive Biotechnologies Corporation | Methods of monitoring conditions by sequence analysis |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US20140037645A1 (en) | 2008-11-07 | 2014-02-06 | National Jewish Health | Diagonsis and treatment of autoimmune diseases by targeting autoimmune-related b cells ("abcs") |
US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
DK3059337T3 (en) | 2009-01-15 | 2019-07-22 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and methods for producing monoclonal antibodies |
AU2010206843B2 (en) | 2009-01-20 | 2015-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell gene expression for diagnosis, prognosis and identification of drug targets |
US9079942B2 (en) | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
ES2903425T3 (en) * | 2009-03-30 | 2022-04-01 | Illumina Inc | Gene expression analysis in single cells |
WO2010138621A2 (en) | 2009-05-26 | 2010-12-02 | The Uab Research Foundation | Diagnosing and treating iga nephropathy |
KR20120060948A (en) | 2009-05-29 | 2012-06-12 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | B cell signature associated with tolerance in transplant recipients |
SG10201403451QA (en) | 2009-06-25 | 2014-09-26 | Hutchinson Fred Cancer Res | Method of measuring adaptive immunity |
US8497071B2 (en) | 2009-06-29 | 2013-07-30 | California Institute Of Technology | Isolation of unknown rearranged T-cell receptors from single cells |
GB2471473A (en) | 2009-06-30 | 2011-01-05 | Owen Mumford Ltd | Syringe sheath remover |
WO2011025826A1 (en) | 2009-08-26 | 2011-03-03 | Research Development Foundation | Methods for creating antibody libraries |
US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
US20110086051A1 (en) | 2009-10-08 | 2011-04-14 | Dartmouth-Hitchcock Clinic | System and method for monitoring and optimizing immune status in transplant recipients |
WO2011049603A1 (en) | 2009-10-22 | 2011-04-28 | Dana-Farber Cancer Institute, Inc. | Biomarkers to identify hiv-specific t-cell subsets |
GB0918564D0 (en) | 2009-10-22 | 2009-12-09 | Plasticell Ltd | Nested cell encapsulation |
ES2821500T3 (en) | 2009-11-06 | 2021-04-26 | Univ Leland Stanford Junior | Non-invasive diagnosis of graft rejection in organ transplant patients |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
CA2789425C (en) | 2010-02-12 | 2020-04-28 | Raindance Technologies, Inc. | Digital analyte analysis with polymerase error correction |
EP2539470B1 (en) | 2010-02-24 | 2017-02-22 | The Board of Trustees of The Leland Stanford Junior University | Methods for autoimmune disease diagnosis, prognosis, and treatment |
CA2794255C (en) | 2010-03-25 | 2020-01-14 | Minnie M. Sarwal | Protein and gene biomarkers for rejection of organ transplants |
EP3456847A1 (en) | 2010-05-06 | 2019-03-20 | Adaptive Biotechnologies Corporation | Monitoring solid transplant rejection using clonotype profiles |
US9234240B2 (en) | 2010-05-07 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
CA2799746C (en) | 2010-05-17 | 2020-11-24 | Sai Reddy | Rapid isolation of monoclonal antibodies from animals |
US9650629B2 (en) | 2010-07-07 | 2017-05-16 | Roche Molecular Systems, Inc. | Clonal pre-amplification in emulsion |
WO2012027503A2 (en) | 2010-08-24 | 2012-03-01 | Fred Hutchinson Cancer Research Center | Method of measuring adaptive immunity |
JP5992911B2 (en) | 2010-09-21 | 2016-09-14 | ポピュレーション ジェネティクス テクノロジーズ リミテッド | Increasing the reliability of allelic calls by molecular counting |
WO2012042374A2 (en) | 2010-10-01 | 2012-04-05 | Anssi Jussi Nikolai Taipale | Method of determining number or concentration of molecules |
US9902950B2 (en) * | 2010-10-08 | 2018-02-27 | President And Fellows Of Harvard College | High-throughput single cell barcoding |
DK2625295T3 (en) | 2010-10-08 | 2019-06-11 | Harvard College | HIGH-THROUGHPUT-IMMUNE SEQUENCING |
WO2012072705A1 (en) | 2010-12-01 | 2012-06-07 | Morphosys Ag | Simultaneous detection of biomolecules in single cells |
US9193997B2 (en) | 2010-12-15 | 2015-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Measuring and monitoring of cell clonality |
EP2652155B1 (en) | 2010-12-16 | 2016-11-16 | Gigagen, Inc. | Methods for massively parallel analysis of nucleic acids in single cells |
US10670608B2 (en) | 2010-12-31 | 2020-06-02 | Bioatla, Llc | Comprehensive monoclonal antibody generation |
DK2663864T3 (en) | 2011-01-14 | 2019-06-24 | Irepertoire Inc | PROCEDURE TO EVALUATE IMMEDIATE VARIETY AND APPLICATION OF THIS |
US9150852B2 (en) * | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
ES2625288T3 (en) | 2011-04-15 | 2017-07-19 | The Johns Hopkins University | Secure Sequencing System |
WO2012149042A2 (en) | 2011-04-25 | 2012-11-01 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
EP3415619B1 (en) * | 2011-04-28 | 2020-12-16 | The Board of Trustees of the Leland Stanford Junior University | Identification of polynucleotides associated with a sample |
EP3216872B1 (en) | 2011-06-02 | 2020-04-01 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
EP3034513B1 (en) | 2011-07-12 | 2020-09-02 | XBiotech, Inc | Identifying affinity-matured human antibodies |
GB2496016B (en) | 2011-09-09 | 2016-03-16 | Univ Leland Stanford Junior | Methods for obtaining a sequence |
US20130078633A1 (en) | 2011-09-22 | 2013-03-28 | ImmuMetrix, LLC | Detection of Isotype Profiles as Signatures for Disease |
US9176031B2 (en) * | 2012-02-24 | 2015-11-03 | Raindance Technologies, Inc. | Labeling and sample preparation for sequencing |
EP2823064B1 (en) * | 2012-03-05 | 2019-02-06 | President and Fellows of Harvard College | Methods for epigenetic sequencing |
CN104903466B (en) | 2012-11-05 | 2016-11-23 | 鲁比康基因组学公司 | Bar coding nucleic acid |
GB2584364A (en) | 2013-03-15 | 2020-12-02 | Abvitro Llc | Single cell bar-coding for antibody discovery |
US20160122753A1 (en) * | 2013-06-12 | 2016-05-05 | Tarjei Mikkelsen | High-throughput rna-seq |
PL3030682T3 (en) * | 2013-08-05 | 2020-11-16 | Twist Bioscience Corporation | De novo synthesized gene libraries |
WO2015103339A1 (en) * | 2013-12-30 | 2015-07-09 | Atreca, Inc. | Analysis of nucleic acids associated with single cells using nucleic acid barcodes |
ES2819277T3 (en) | 2014-02-11 | 2021-04-15 | Hoffmann La Roche | Directed Sequencing and UID Filtering |
AU2015222944A1 (en) * | 2014-02-27 | 2016-09-08 | Massachusetts Institute Of Technology | T cell balance gene expression, compositions of matters and methods of use thereof |
MX2017003382A (en) | 2014-09-15 | 2017-11-20 | Abvitro Llc | High-throughput nucleotide library sequencing. |
-
2015
- 2015-09-15 MX MX2017003382A patent/MX2017003382A/en unknown
- 2015-09-15 WO PCT/US2015/050119 patent/WO2016044227A1/en active Application Filing
- 2015-09-15 SG SG10201911069WA patent/SG10201911069WA/en unknown
- 2015-09-15 AU AU2015318011A patent/AU2015318011B2/en active Active
- 2015-09-15 JP JP2017533733A patent/JP6672310B2/en active Active
- 2015-09-15 ES ES18214901T patent/ES2895750T3/en active Active
- 2015-09-15 CA CA2961210A patent/CA2961210A1/en active Pending
- 2015-09-15 US US14/854,399 patent/US10590483B2/en active Active
- 2015-09-15 KR KR1020177010295A patent/KR102541849B1/en active IP Right Grant
- 2015-09-15 SG SG11201702060VA patent/SG11201702060VA/en unknown
- 2015-09-15 CN CN201580062006.4A patent/CN107002076B/en active Active
- 2015-09-15 EP EP21178041.6A patent/EP3950944A1/en active Pending
- 2015-09-15 EP EP18214901.3A patent/EP3536786B1/en active Active
- 2015-09-15 ES ES15778415T patent/ES2727656T3/en active Active
- 2015-09-15 EP EP15778415.8A patent/EP3194593B1/en active Active
-
2017
- 2017-03-13 IL IL251123A patent/IL251123B/en active IP Right Grant
- 2017-03-17 ZA ZA2017/01916A patent/ZA201701916B/en unknown
-
2020
- 2020-02-03 US US16/780,234 patent/US20200239955A1/en not_active Abandoned
- 2020-03-04 JP JP2020036503A patent/JP6960490B2/en active Active
- 2020-07-02 AU AU2020204449A patent/AU2020204449B2/en active Active
-
2021
- 2021-10-11 JP JP2021166730A patent/JP7278352B2/en active Active
-
2022
- 2022-11-10 US US18/054,344 patent/US20240076732A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3536786B1 (en) | 2021-06-30 |
CA2961210A1 (en) | 2016-03-24 |
AU2015318011A1 (en) | 2017-04-06 |
EP3950944A1 (en) | 2022-02-09 |
JP6672310B2 (en) | 2020-03-25 |
US20240076732A1 (en) | 2024-03-07 |
JP2017527313A (en) | 2017-09-21 |
CN107002076A (en) | 2017-08-01 |
SG11201702060VA (en) | 2017-04-27 |
EP3536786A1 (en) | 2019-09-11 |
IL251123A0 (en) | 2017-04-30 |
IL251123B (en) | 2020-08-31 |
US10590483B2 (en) | 2020-03-17 |
EP3194593A1 (en) | 2017-07-26 |
AU2020204449B2 (en) | 2022-03-17 |
JP6960490B2 (en) | 2021-11-05 |
AU2020204449A1 (en) | 2020-07-23 |
US20200239955A1 (en) | 2020-07-30 |
ZA201701916B (en) | 2020-10-28 |
ES2727656T3 (en) | 2019-10-17 |
US20160244825A1 (en) | 2016-08-25 |
MX2017003382A (en) | 2017-11-20 |
KR20170063726A (en) | 2017-06-08 |
EP3194593B1 (en) | 2019-02-06 |
KR102541849B1 (en) | 2023-06-09 |
AU2015318011B2 (en) | 2020-07-23 |
ES2895750T3 (en) | 2022-02-22 |
JP2022023115A (en) | 2022-02-07 |
WO2016044227A1 (en) | 2016-03-24 |
JP2020108382A (en) | 2020-07-16 |
CN107002076B (en) | 2021-11-23 |
JP7278352B2 (en) | 2023-05-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201701916B (en) | High-throughput nucleotide library sequencing | |
HK1256688A1 (en) | Nuclease-mediated dna assembly | |
HK1245830A1 (en) | Sequencing controls | |
SG11201706636PA (en) | Single-cell nucleic acids for high-throughput studies | |
EP3174993C0 (en) | Probe library construction | |
EP3394292A4 (en) | Methods of library construction for polynucleotide sequencing | |
SG11201610168YA (en) | Nucleic acid synthesis techniques | |
IL250836A0 (en) | Nucleotide analogs | |
HK1243958A1 (en) | Nucleic acid construct | |
GB201507119D0 (en) | Nucleic Acid Construct | |
GB201412977D0 (en) | Single nucleotide detection method | |
HK1245346A1 (en) | High-throughput sequencing of polynucleotides | |
GB201507115D0 (en) | Nucleic Acid Construct | |
GB201507111D0 (en) | Nucleic acid construct | |
GB201507104D0 (en) | Nucleic acid construct | |
SG11201609754QA (en) | Sequencing process | |
GB201418144D0 (en) | High throughput sequencing | |
IL257500A (en) | Modified cullin1 gene | |
GB201517241D0 (en) | DNA modification | |
GB201415674D0 (en) | Nucleic acid analysis | |
GB201402996D0 (en) | Variant analysis in high-throughput sequencing applications | |
GB201709308D0 (en) | Variant nucleotide library | |
GB201503465D0 (en) | Sequencing methods | |
GB201416211D0 (en) | Sequencing techniques | |
GB201409785D0 (en) | Sequencing Techniques |