SG10201909122QA - Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases - Google Patents

Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases

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Publication number
SG10201909122QA
SG10201909122QA SG10201909122QA SG10201909122QA SG 10201909122Q A SG10201909122Q A SG 10201909122QA SG 10201909122Q A SG10201909122Q A SG 10201909122QA SG 10201909122Q A SG10201909122Q A SG 10201909122QA
Authority
SG
Singapore
Prior art keywords
pediatric
treatment
bile acid
cholestatic liver
liver diseases
Prior art date
Application number
Inventor
Bronislava Gedulin
Michael Grey
Niall O'donnell
Original Assignee
Lumena Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48168608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201909122Q(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lumena Pharmaceuticals Inc filed Critical Lumena Pharmaceuticals Inc
Publication of SG10201909122QA publication Critical patent/SG10201909122QA/en

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES Provided herein are pediatric dosage forms for use in the treatment of a pediatric cholestatic liver disease by non-systemically administering to an individual in need thereof a therapeutically effective amount of the pediatric dosage form comprising an Apical Sodium- dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are said pediatric dosage form for use in the treatment of a pediatric liver disease, for use in decreasing the levels of serum bile acids or hepatic bile acids, for use in the treatment of pruritis, for use in reducing liver enzymes or bilirubin comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an ASBTI or a pharmaceutically acceptable salt thereof. FIG. 5
SG10201909122Q 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases SG10201909122QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161553094P 2011-10-28 2011-10-28
US201261607503P 2012-03-06 2012-03-06
US201261607487P 2012-03-06 2012-03-06

Publications (1)

Publication Number Publication Date
SG10201909122QA true SG10201909122QA (en) 2019-11-28

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Family Applications (3)

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SG11201401849QA (en) 2014-05-29
CN104023727B (en) 2017-04-05
FIC20230019I1 (en) 2023-05-24
JP7237544B2 (en) 2023-03-13
US20220023296A1 (en) 2022-01-27
US20170368085A1 (en) 2017-12-28
US20160310518A1 (en) 2016-10-27
AU2019202884B2 (en) 2021-03-04
IL232150A (en) 2017-12-31
AU2017213485A1 (en) 2017-08-31
ES2633766T3 (en) 2017-09-25
CN107375932A (en) 2017-11-24
JP2019055970A (en) 2019-04-11

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