GB1269551A - New tricyclic derivatives and process for their manufacture - Google Patents

New tricyclic derivatives and process for their manufacture

Info

Publication number
GB1269551A
GB1269551A GB1611669A GB1611669A GB1269551A GB 1269551 A GB1269551 A GB 1269551A GB 1611669 A GB1611669 A GB 1611669A GB 1611669 A GB1611669 A GB 1611669A GB 1269551 A GB1269551 A GB 1269551A
Authority
GB
United Kingdom
Prior art keywords
general formula
alkyl group
tricyclic
resulting
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1611669A
Inventor
Charles Malen
Jean Claude Poignant
Bernard Danree
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to GB1611669A priority Critical patent/GB1269551A/en
Priority to NL7003429A priority patent/NL140526B/en
Priority to DE19702065636 priority patent/DE2065636C3/en
Priority to DE19702065635 priority patent/DE2065635C3/en
Priority to DE19702011806 priority patent/DE2011806C3/en
Priority to FR7009863A priority patent/FR2037266B1/fr
Priority to DK145070A priority patent/DK133976B/en
Priority to ES377906A priority patent/ES377906A1/en
Priority to CH454770A priority patent/CH522595A/en
Priority to BE748032D priority patent/BE748032A/en
Priority to SE428970A priority patent/SE368005B/xx
Priority to FR7132197A priority patent/FR2104728B1/fr
Priority to FR7132198A priority patent/FR2104729B1/fr
Publication of GB1269551A publication Critical patent/GB1269551A/en
Priority to SE7305057A priority patent/SE402104B/en
Priority to NL737314583A priority patent/NL154507B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/16—Eight-membered rings

Abstract

1,269,551. Tricyclic compounds. SCIENCE UNION ET CIE SOC. FRANCAISE DE RECHERCHE MEDICALE. 12 March, 1970 [27 March, 1969], No. 16116/69. Heading C2C. Novel tricyclic compounds of the general formula wherein A is -(CH 2 ) m -, -CH=CH-, -(CH 2 ) p O-, -(CH 2 ) p S-, -(CH 2 ) p SO 2 -, -(CH 2 ) p NR 1 - or -SO 2 NR 2 -, in which m is 1, 2 or 3, p is 1 or 2, R 1 is a hydrogen atom or a C 1-5 alkyl group and R 2 is a C 1-5 alkyl group, X and Y are each a hydrogen or halogen atom, R and R<SP>1</SP> are each a hydrogen atom or a C 1-5 alkyl group and n is an integer from 1 to 12 inclusive, and salts thereof are prepared by condensation of an aminoalkanoic acid ester of the general formula RNH(CH 2 ) n COOR<SP>1</SP>, wherein R<SP>1</SP> is a C 1-5 alkyl group, with a halide of the general formula wherein Hal is a chlorine or bromine atom, and optional saponification of the resulting ester of the first general formula above to give the corresponding free acid, followed optionally by salification of the product with an acid or base. Halides of the third general formula above are prepared by cyclization of a suitable o- (phenyl-A)-benzoic acid, reduction of the resulting tricyclic ketone and halogenation of the resulting hydroxy compound. Pharmaceutical compositions having psychostimulant, antidepressive, analgesic, antitussive, antihistaminic and gastric antisecretory activity comprise, as active ingredient, a tricyclic compound of the first general formula above or a physiologically tolerable salt thereof, together with a pharmaceutically suitable carrier, and may be administered orally, rectally or parenterally.
GB1611669A 1969-03-27 1969-03-27 New tricyclic derivatives and process for their manufacture Expired GB1269551A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GB1611669A GB1269551A (en) 1969-03-27 1969-03-27 New tricyclic derivatives and process for their manufacture
NL7003429A NL140526B (en) 1969-03-27 1970-03-11 PROCESS FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE DIBENZOTHIAZEPINES, PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS AND FORMED PHARMACEUTICAL PREPARATIONS.
DE19702065636 DE2065636C3 (en) 1969-03-27 1970-03-12 Tricyclic compounds, processes for their preparation and medicaments containing them
DE19702065635 DE2065635C3 (en) 1969-03-27 1970-03-12 10-Dioxo-11-methyldibenzothiazepine derivatives, processes for their production and pharmaceutical preparations containing them
DE19702011806 DE2011806C3 (en) 1969-03-27 1970-03-12 Tricyclic compounds, processes for their preparation and pharmaceutical preparations containing them
FR7009863A FR2037266B1 (en) 1969-03-27 1970-03-19
DK145070A DK133976B (en) 1969-03-27 1970-03-20 Analogous process for the preparation of tricyclic compounds or the addition salts of these compounds.
ES377906A ES377906A1 (en) 1969-03-27 1970-03-24 New tricyclic derivatives and process for their manufacture
CH454770A CH522595A (en) 1969-03-27 1970-03-25 Process for the preparation of new tricyclic derivatives
BE748032D BE748032A (en) 1969-03-27 1970-03-26 TRICYCLIC DERIVATIVES AND THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS HAVING PSYCHOSTIMULANT, ANTIDEPRESSIVE, ANALGESIC, ANTITUSSIVE, ANTIHISTAMINIC AND GASTRIC ANTISECRETORY PROPERTIES
SE428970A SE368005B (en) 1969-03-27 1970-03-26
FR7132197A FR2104728B1 (en) 1969-03-27 1971-09-07
FR7132198A FR2104729B1 (en) 1969-03-27 1971-09-07
SE7305057A SE402104B (en) 1969-03-27 1973-04-10 WAY TO PRODUCE NEW DIBENSOTIAZEPINES AND DIBENSOTIEPINES INTENDED TO BE USED AS A MEDICINE
NL737314583A NL154507B (en) 1969-03-27 1973-10-24 Process for the preparation of a pharmaceutical composition comprising a pharmacologically active derivative of a tricyclic fused ring system CONTAINING aminocarboxylate CONTAINS AND THE RESULTING SHAPED PHARMACEUTICAL PREPARATION AND METHOD FOR PRODUCING A RECORDING IN SUCH PREPARATION SUITABLE DERIVATIVE OF A tricyclic fused ring system CONTAINING AMINOCARBONIC ACID.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1611669A GB1269551A (en) 1969-03-27 1969-03-27 New tricyclic derivatives and process for their manufacture

Publications (1)

Publication Number Publication Date
GB1269551A true GB1269551A (en) 1972-04-06

Family

ID=10071471

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1611669A Expired GB1269551A (en) 1969-03-27 1969-03-27 New tricyclic derivatives and process for their manufacture

Country Status (9)

Country Link
BE (1) BE748032A (en)
CH (1) CH522595A (en)
DE (3) DE2065636C3 (en)
DK (1) DK133976B (en)
ES (1) ES377906A1 (en)
FR (3) FR2037266B1 (en)
GB (1) GB1269551A (en)
NL (1) NL140526B (en)
SE (2) SE368005B (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683072B1 (en) 2003-02-04 2004-01-27 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia
WO2004087131A1 (en) * 2003-03-31 2004-10-14 Kyowa Hakko Kogyo Co., Ltd. Antitussives
WO2009073154A1 (en) * 2007-11-28 2009-06-11 Nektar Therapeutics Al, Corporation Oligomer-tricyclic conjugates
US8198268B2 (en) 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
ITMI20111308A1 (en) * 2011-07-14 2013-01-15 Cosma S P A METHOD OF PREPARATION OF TIANEPTINA SALE SODICO
EP2561864A1 (en) 2011-08-25 2013-02-27 Zaklady Farmaceutyczne Polpharma SA Coated tablet comprising tianeptine and process for preparation thereof
WO2013167906A1 (en) 2012-05-11 2013-11-14 Numedicus Limited Treatment of respiratory depression
JP2017507960A (en) * 2014-03-12 2017-03-23 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｃｏｌｕｍｂｉａ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎ Ｔｈｅ Ｃｉｔｙ Ｏｆ Ｎｅｗ Ｙｏｒｋ A new class of mu-opioid receptor agonists
WO2017049158A1 (en) 2015-09-16 2017-03-23 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH629667A5 (en) * 1978-03-28 1982-05-14 Science Union & Cie PHARMACEUTICAL COMPOSITION ACTING ON GASTROINTESTINAL MOTORITY.
FR2594827B1 (en) * 1986-02-21 1988-05-20 Adir NEW TRICYCLIC DERIVATIVE ACID ((CHLORO-3 METHYL-6 DIOXO-5.5 DIHYDRO-6, 11 DIBENZO (C, F) THIAZEPINE (1,2) YL-11 AMINO) -5 PENTAZOIQUE, ITS PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
JPH0578292A (en) * 1991-04-05 1993-03-30 Hokuriku Seiyaku Co Ltd Tricyclic compound
FR2716623B1 (en) 1994-02-25 1996-08-23 Adir Use of a tricyclic derivative for obtaining medicaments intended for the treatment of mnemo-cognitive disorders.
US6221897B1 (en) 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
FR2807039A1 (en) 2000-03-31 2001-10-05 Adir NOVEL PROCESS FOR THE PREPARATION OF 11-AMINO-3-CHLORO-6,11-DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO [c, f] [1,2] -THIAZEPINE AND APPLICATION TO THE SYNTHESIS OF TIANEPTINE
WO2010070667A2 (en) * 2008-11-19 2010-06-24 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate
US8355927B2 (en) 2010-11-05 2013-01-15 Genomind, Llc Neuropsychiatric test reports
GB201106520D0 (en) 2011-04-18 2011-06-01 Numedicus Ltd Pharmaceutical compounds
BRPI1104695B1 (en) * 2011-09-02 2020-10-27 Universidade Federal Do Rio Grande Do Sul tianeptine derivatives, pharmaceutical compositions, use, and process for their production
CN107375932B (en) 2011-10-28 2021-12-21 夏尔人类遗传性治疗公司 Bile acid recirculation inhibitor for treating children cholestatic liver disease
KR102199871B1 (en) 2018-12-21 2021-01-08 주식회사 한서켐 A process for preparing 3,11-Dichloro-6-methyl -6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543035A1 (en) * 1965-01-06 1969-09-25 Hoffmann La Roche Process for the preparation of dibenzocycloheptene compounds

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683072B1 (en) 2003-02-04 2004-01-27 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia
WO2004087131A1 (en) * 2003-03-31 2004-10-14 Kyowa Hakko Kogyo Co., Ltd. Antitussives
US9725431B2 (en) 2007-11-28 2017-08-08 Nektar Therapeutics Oligomer-tricyclic conjugates
WO2009073154A1 (en) * 2007-11-28 2009-06-11 Nektar Therapeutics Al, Corporation Oligomer-tricyclic conjugates
US8569380B2 (en) 2007-11-28 2013-10-29 Nektar Therapeutics Oligomer-tricyclic conjugates
US8198268B2 (en) 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
ITMI20111308A1 (en) * 2011-07-14 2013-01-15 Cosma S P A METHOD OF PREPARATION OF TIANEPTINA SALE SODICO
EP2561864A1 (en) 2011-08-25 2013-02-27 Zaklady Farmaceutyczne Polpharma SA Coated tablet comprising tianeptine and process for preparation thereof
WO2013167906A1 (en) 2012-05-11 2013-11-14 Numedicus Limited Treatment of respiratory depression
JP2017507960A (en) * 2014-03-12 2017-03-23 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｃｏｌｕｍｂｉａ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎ Ｔｈｅ Ｃｉｔｙ Ｏｆ Ｎｅｗ Ｙｏｒｋ A new class of mu-opioid receptor agonists
EP3116509A4 (en) * 2014-03-12 2017-08-23 The Trustees of Columbia University in the City of New York A new class of mu-opioid receptor agonists
US10183919B2 (en) 2014-03-12 2019-01-22 The Trustees Of Columbia University In The City Of New York Class of mu-opioid receptor agonists
AU2015229258B2 (en) * 2014-03-12 2020-01-30 The Trustees Of Columbia University In The City Of New York A new class of Mu-Opioid receptor agonists
WO2017049158A1 (en) 2015-09-16 2017-03-23 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
EP3349739A4 (en) * 2015-09-16 2019-02-13 The Trustees of Columbia University in the City of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
US10844027B2 (en) 2015-09-16 2020-11-24 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
AU2016323977B2 (en) * 2015-09-16 2021-02-25 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
AU2016323977B9 (en) * 2015-09-16 2021-03-04 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists

Also Published As

Publication number Publication date
DE2065635B2 (en) 1979-02-08
DE2011806A1 (en) 1970-10-15
FR2104729A1 (en) 1972-04-21
FR2104728B1 (en) 1974-05-24
DE2065635C3 (en) 1979-10-04
DE2065636B2 (en) 1978-11-16
FR2104729B1 (en) 1974-05-24
SE368005B (en) 1974-06-17
DE2011806B2 (en) 1981-01-08
BE748032A (en) 1970-09-28
ES377906A1 (en) 1972-06-16
SE402104B (en) 1978-06-19
NL140526B (en) 1973-12-17
FR2037266B1 (en) 1974-05-24
DK133976C (en) 1977-03-21
DE2065635A1 (en) 1974-09-05
DK133976B (en) 1976-08-23
FR2037266A1 (en) 1970-12-31
DE2011806C3 (en) 1981-12-03
FR2104728A1 (en) 1972-04-21
DE2065636A1 (en) 1974-12-19
NL7003429A (en) 1970-09-29
CH522595A (en) 1972-06-30
DE2065636C3 (en) 1979-07-19

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