SG10201503534RA - Monitoring health and disease status using clonotype profiles - Google Patents
Monitoring health and disease status using clonotype profilesInfo
- Publication number
- SG10201503534RA SG10201503534RA SG10201503534RA SG10201503534RA SG10201503534RA SG 10201503534R A SG10201503534R A SG 10201503534RA SG 10201503534R A SG10201503534R A SG 10201503534RA SG 10201503534R A SG10201503534R A SG 10201503534RA SG 10201503534R A SG10201503534R A SG 10201503534RA
- Authority
- SG
- Singapore
- Prior art keywords
- disease status
- monitoring health
- clonotype profiles
- clonotype
- profiles
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5052—Cells of the immune system involving B-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Physiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33217510P | 2010-05-06 | 2010-05-06 | |
US45574310P | 2010-10-25 | 2010-10-25 | |
US201161446822P | 2011-02-25 | 2011-02-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201503534RA true SG10201503534RA (en) | 2015-06-29 |
Family
ID=44903937
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012081527A SG185128A1 (en) | 2010-05-06 | 2011-05-04 | Monitoring health and disease status using clonotype profiles |
SG10201503534RA SG10201503534RA (en) | 2010-05-06 | 2011-05-04 | Monitoring health and disease status using clonotype profiles |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012081527A SG185128A1 (en) | 2010-05-06 | 2011-05-04 | Monitoring health and disease status using clonotype profiles |
Country Status (9)
Country | Link |
---|---|
EP (4) | EP2567226B1 (en) |
JP (4) | JP6085249B2 (en) |
CN (2) | CN104673899A (en) |
AU (1) | AU2011249041B2 (en) |
CA (1) | CA2798431C (en) |
DK (2) | DK2567226T3 (en) |
ES (2) | ES2740802T3 (en) |
SG (2) | SG185128A1 (en) |
WO (2) | WO2011139372A1 (en) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9394567B2 (en) | 2008-11-07 | 2016-07-19 | Adaptive Biotechnologies Corporation | Detection and quantification of sample contamination in immune repertoire analysis |
SG195652A1 (en) | 2008-11-07 | 2013-12-30 | Sequenta Inc | Methods of monitoring conditions by sequence analysis |
HUE029424T2 (en) | 2009-01-15 | 2017-02-28 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
JP2012531202A (en) | 2009-06-25 | 2012-12-10 | フレッド ハチンソン キャンサー リサーチ センター | How to measure adaptive immunity |
US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
DK2652155T3 (en) | 2010-12-16 | 2017-02-13 | Gigagen Inc | Methods for Massive Parallel Analysis of Nucleic Acids in Single Cells |
KR20210131432A (en) | 2010-12-30 | 2021-11-02 | 파운데이션 메디신 인코포레이티드 | Optimization of multigene analysis of tumor samples |
WO2012097374A1 (en) * | 2011-01-14 | 2012-07-19 | Cb Biotechnologies, Inc. | Immunodiversity assessment method and its use |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
EP2768982A4 (en) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | Quantification of adaptive immune cell genomes in a complex mixture of cells |
EP2788509B1 (en) * | 2011-12-09 | 2018-07-11 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
JP2015504661A (en) * | 2011-12-20 | 2015-02-16 | シーケンタ インコーポレイテッド | Monitoring of transformation from follicular lymphoma to diffuse large B-cell lymphoma by immunorepertoire analysis |
EP2823060B1 (en) | 2012-03-05 | 2018-02-14 | Adaptive Biotechnologies Corporation | Determining paired immune receptor chains from frequency matched subunits |
WO2013155119A1 (en) * | 2012-04-13 | 2013-10-17 | Sequenta, Inc. | Detection and quantitation of sample contamination in immune repertoire analysis |
DK2831276T3 (en) | 2012-05-08 | 2016-08-01 | Adaptive Biotechnologies Corp | Compositions and Methods for Measuring and Calibrating Amplification Bias in Multiplex PCR Reactions |
WO2013181428A2 (en) * | 2012-05-31 | 2013-12-05 | Sequenta, Inc. | Predicting relapse of chronic lymphocytic leukemia patients treated by allogeneic stem cell transplantation |
AU2013273987B2 (en) * | 2012-06-15 | 2018-08-09 | Adaptive Biotechnologies Corporation | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
EP2882870A4 (en) * | 2012-08-10 | 2016-03-16 | Sequenta Inc | High sensitivity mutation detection using sequence tags |
ES2749118T3 (en) | 2012-10-01 | 2020-03-19 | Adaptive Biotechnologies Corp | Assessment of immunocompetence for adaptive immunity receptor diversity and clonality characterization |
US20150247198A1 (en) * | 2012-10-19 | 2015-09-03 | Sequenta, Inc. | Monitoring clonotypes of plasma cell proliferative disorders in peripheral blood |
WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
EP2909348A4 (en) * | 2012-10-22 | 2016-07-06 | Adaptive Biotechnologies Corp | Monitoring mantle cell lymphoma clonotypes in peripheral blood after immunotransplant |
JP6460343B2 (en) * | 2013-02-11 | 2019-01-30 | アイレパートリー インコーポレイテッド | Method for assessing the immune repertoire |
AU2014218910A1 (en) * | 2013-02-22 | 2015-08-20 | Adaptive Biotechnologies Corp. | Rare clonotypes and uses thereof |
KR20150132479A (en) * | 2013-03-15 | 2015-11-25 | 어댑티브 바이오테크놀로지스 코포레이션 | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
GB2584364A (en) | 2013-03-15 | 2020-12-02 | Abvitro Llc | Single cell bar-coding for antibody discovery |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
JP6164759B2 (en) * | 2013-11-21 | 2017-07-19 | Repertoire Genesis株式会社 | Analysis system for T cell receptor and B cell receptor repertoire and its use for therapy and diagnosis |
WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
US10202640B2 (en) | 2014-05-07 | 2019-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing |
US10590483B2 (en) | 2014-09-15 | 2020-03-17 | Abvitro Llc | High-throughput nucleotide library sequencing |
CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
US11066705B2 (en) | 2014-11-25 | 2021-07-20 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
EP3227464B1 (en) | 2014-12-05 | 2022-04-20 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
AU2016222788B2 (en) | 2015-02-24 | 2022-03-31 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
US9422547B1 (en) | 2015-06-09 | 2016-08-23 | Gigagen, Inc. | Recombinant fusion proteins and libraries from immune cell repertoires |
CN106557536B (en) * | 2015-09-30 | 2021-12-21 | 松下知识产权经营株式会社 | Control method |
US10130658B2 (en) * | 2015-12-18 | 2018-11-20 | Provectus Pharmatech, Inc. | Method of ex vivo enhancement of immune cell activity for cancer immunotherapy with a small molecule ablative compound |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
CN107955831A (en) * | 2016-10-13 | 2018-04-24 | 深圳华大基因研究院 | The label and lymphocyte quantitative detecting method quantitatively detected for lymphocyte |
GB201618485D0 (en) * | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
KR102209364B1 (en) * | 2016-12-09 | 2021-02-01 | 리제너론 파아마슈티컬스, 인크. | Systems and methods for sequencing T cell receptors and uses thereof |
RU2674994C2 (en) * | 2016-12-29 | 2018-12-14 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Method for determining markers of presence of tumor t-lymphoblasts |
EP4212631A1 (en) | 2017-09-01 | 2023-07-19 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
CN111448312A (en) | 2017-10-10 | 2020-07-24 | 国立大学法人广岛大学 | Technique for making antigen-specific regulatory T cells (Tregs) using effector T cell (Teff) antigen receptors |
JP7207661B2 (en) | 2017-10-10 | 2023-01-18 | 国立大学法人広島大学 | Technology for complete replacement of T-cell receptors using platinum TALENs |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
WO2019196088A1 (en) * | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
CN112292600A (en) * | 2018-06-15 | 2021-01-29 | 豪夫迈·罗氏有限公司 | System for identifying antigens recognized by T cell receptors expressed on tumor infiltrating lymphocytes |
CN109002689B (en) * | 2018-07-23 | 2020-10-09 | 西安交通大学医学院第一附属医院 | T cell data processing method and device |
WO2020102721A1 (en) * | 2018-11-16 | 2020-05-22 | Rapa Therapeutics, Llc | Immune monitoring of neuro-inflammatory amyotrophic lateral sclerosis (als) |
EP3941491A4 (en) | 2019-03-21 | 2023-03-29 | Gigamune, Inc. | Engineered cells expressing anti-viral t cell receptors and methods of use thereof |
CN110988364A (en) * | 2019-12-31 | 2020-04-10 | 天津美瑞特医疗科技有限公司 | Method for detecting GVHD (GVHD-associated cytokine) after transplantation by using flow cytometry and detection kit |
CN111808195A (en) * | 2020-06-30 | 2020-10-23 | 中国科学院心理研究所 | Method for obtaining B cell antibody gene of anti-N-methyl-D-aspartate receptor encephalitis and research on immune repertoire thereof |
CN111524548B (en) * | 2020-07-03 | 2020-10-23 | 至本医疗科技(上海)有限公司 | Method, computing device, and computer storage medium for detecting IGH reordering |
CA3214486A1 (en) | 2021-03-24 | 2022-09-29 | Genentech, Inc. | Efficient tcr gene editing in t lymphocytes |
CN113637741B (en) * | 2021-09-29 | 2023-12-01 | 成都二十三魔方生物科技有限公司 | Early-onset white hair genetic risk gene detection kit, early-onset white hair genetic risk assessment system and early-onset white hair genetic risk assessment method |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
US4942124A (en) | 1987-08-11 | 1990-07-17 | President And Fellows Of Harvard College | Multiplex sequencing |
US5168038A (en) | 1988-06-17 | 1992-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | In situ transcription in cells and tissues |
US5296351A (en) | 1988-10-20 | 1994-03-22 | Alexander A. Morley | Method for diagnosis of monoclonality in leukaemia and lymphoma |
CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
JP3080178B2 (en) | 1991-02-18 | 2000-08-21 | 東洋紡績株式会社 | Method for amplifying nucleic acid sequence and reagent kit therefor |
US5981179A (en) | 1991-11-14 | 1999-11-09 | Digene Diagnostics, Inc. | Continuous amplification reaction |
US5837447A (en) | 1992-04-15 | 1998-11-17 | Blood Center Research Foundation, Inc., The | Monitoring an immune response by analysis of amplified immunoglobulin or T-cell-receptor nucleic acid |
US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
US6090592A (en) | 1994-08-03 | 2000-07-18 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid on supports |
US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US5635363A (en) | 1995-02-28 | 1997-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for the detection, quantitation and purification of antigen-specific T cells |
US6087096A (en) | 1995-11-13 | 2000-07-11 | Dau; Peter C. | Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
KR19990087749A (en) * | 1996-03-13 | 1999-12-27 | 시오노 요시히코 | Human T Cell Clones Specific to Rheumatoid Arthritis |
US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
CA2257152C (en) * | 1996-06-03 | 2009-01-27 | Linda M. Pilarski | Methods for detection of rearranged dna |
US6174670B1 (en) | 1996-06-04 | 2001-01-16 | University Of Utah Research Foundation | Monitoring amplification of DNA during PCR |
US5846928A (en) | 1996-08-01 | 1998-12-08 | Pasken Products Co., Ltd. | Method for treating cancer patients |
ES2277358T3 (en) | 1996-09-06 | 2007-07-01 | Ortho-Mcneil Pharmaceutical, Inc. | PURIFICATION OF ANTIGEN T SPECIFIC CELLS. |
GB9626815D0 (en) * | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
AU6846698A (en) | 1997-04-01 | 1998-10-22 | Glaxo Group Limited | Method of nucleic acid amplification |
US6008002A (en) | 1997-09-29 | 1999-12-28 | Bodey; Bela | Immunomagnetic detection and isolation of cancer cells |
AU760560B2 (en) | 1998-02-12 | 2003-05-15 | Board Of Regents, The University Of Texas System | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
DE19833738A1 (en) | 1998-07-27 | 2000-02-03 | Michael Giesing | Process for isolating cancer cells from cell-containing body fluids and kits for performing this process |
AR021833A1 (en) | 1998-09-30 | 2002-08-07 | Applied Research Systems | METHODS OF AMPLIFICATION AND SEQUENCING OF NUCLEIC ACID |
US6300070B1 (en) | 1999-06-04 | 2001-10-09 | Mosaic Technologies, Inc. | Solid phase methods for amplifying multiple nucleic acids |
US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
EP1227321A1 (en) | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
GB0128153D0 (en) | 2001-11-23 | 2002-01-16 | Bayer Ag | Profiling of the immune gene repertoire |
ATE483822T1 (en) * | 2002-10-11 | 2010-10-15 | Univ Erasmus | PRIMERS FOR NUCLEIC ACID AMPLIFICATION IN PCR-BASED CLONALITY STUDIES |
WO2004069849A2 (en) | 2003-01-29 | 2004-08-19 | 454 Corporation | Bead emulsion nucleic acid amplification |
AU2003902299A0 (en) | 2003-05-13 | 2003-05-29 | Flinders Medical Centre | A method of analysing a marker nucleic acid molecule |
DE60326052D1 (en) | 2003-12-15 | 2009-03-19 | Pasteur Institut | Determination of the repertoire of B lymphocyte populations |
EP1784646B1 (en) | 2004-08-11 | 2012-06-13 | Albert Einstein College Of Medicine Of Yeshiva University | Method for identifying metastasis in motile cells |
US8426146B2 (en) * | 2005-06-03 | 2013-04-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multiparameteric method for assessing immune system status |
US7993821B2 (en) | 2005-08-11 | 2011-08-09 | University Of Washington | Methods and apparatus for the isolation and enrichment of circulating tumor cells |
US7375211B2 (en) * | 2005-11-18 | 2008-05-20 | Kou Zhong C | Method for detection and quantification of T-cell receptor Vβ repertoire |
WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
CN101225441B (en) * | 2007-12-05 | 2010-12-01 | 浙江大学 | Method for detecting genetic constitution of clone-specific T lymphocyte TCR BV CDR3 |
US11051733B2 (en) | 2008-01-18 | 2021-07-06 | Wake Forest University Health Sciences | Isolating and purifying cells for therapy |
EP2088205A1 (en) * | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: A diagnosis marker and therapeutic target of chronic rejection. |
US20090226975A1 (en) * | 2008-03-10 | 2009-09-10 | Illumina, Inc. | Constant cluster seeding |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
SG195652A1 (en) | 2008-11-07 | 2013-12-30 | Sequenta Inc | Methods of monitoring conditions by sequence analysis |
US8574835B2 (en) | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
WO2011106738A2 (en) * | 2010-02-25 | 2011-09-01 | Fred Hutchinson Cancer Research Center | Use of tcr clonotypes as biomarkers for disease |
-
2011
- 2011-05-04 DK DK11777704.5T patent/DK2567226T3/en active
- 2011-05-04 ES ES16183402T patent/ES2740802T3/en active Active
- 2011-05-04 DK DK16183402.3T patent/DK3144673T3/en active
- 2011-05-04 CA CA2798431A patent/CA2798431C/en active Active
- 2011-05-04 EP EP11777704.5A patent/EP2567226B1/en active Active
- 2011-05-04 EP EP16183402.3A patent/EP3144673B1/en active Active
- 2011-05-04 EP EP23155863.6A patent/EP4219759A3/en active Pending
- 2011-05-04 SG SG2012081527A patent/SG185128A1/en unknown
- 2011-05-04 WO PCT/US2011/000792 patent/WO2011139372A1/en active Application Filing
- 2011-05-04 EP EP18201137.9A patent/EP3456847A1/en active Pending
- 2011-05-04 JP JP2013509047A patent/JP6085249B2/en active Active
- 2011-05-04 AU AU2011249041A patent/AU2011249041B2/en active Active
- 2011-05-04 CN CN201510054401.XA patent/CN104673899A/en active Pending
- 2011-05-04 ES ES11777704.5T patent/ES2593614T3/en active Active
- 2011-05-04 WO PCT/US2011/000791 patent/WO2011139371A1/en active Application Filing
- 2011-05-04 JP JP2013509046A patent/JP6158080B2/en active Active
- 2011-05-04 CN CN201180033142.2A patent/CN103097888B/en active Active
- 2011-05-04 SG SG10201503534RA patent/SG10201503534RA/en unknown
-
2017
- 2017-06-07 JP JP2017112502A patent/JP6246971B2/en active Active
- 2017-11-15 JP JP2017219812A patent/JP6533272B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2011249041A1 (en) | 2012-11-22 |
JP2013524848A (en) | 2013-06-20 |
CA2798431C (en) | 2018-10-23 |
DK2567226T3 (en) | 2016-10-10 |
EP4219759A2 (en) | 2023-08-02 |
EP2567226A1 (en) | 2013-03-13 |
EP3144673B1 (en) | 2019-07-10 |
CN103097888A (en) | 2013-05-08 |
JP2013524849A (en) | 2013-06-20 |
CA2798431A1 (en) | 2011-11-10 |
CN103097888B (en) | 2016-03-09 |
ES2593614T3 (en) | 2016-12-12 |
EP2567226A4 (en) | 2013-08-28 |
JP6085249B2 (en) | 2017-02-22 |
JP6246971B2 (en) | 2017-12-13 |
AU2011249041B2 (en) | 2014-10-30 |
SG185128A1 (en) | 2012-12-28 |
JP2017205112A (en) | 2017-11-24 |
JP6533272B2 (en) | 2019-06-19 |
WO2011139372A1 (en) | 2011-11-10 |
EP2567226B1 (en) | 2016-08-10 |
JP2018068300A (en) | 2018-05-10 |
EP3456847A1 (en) | 2019-03-20 |
JP6158080B2 (en) | 2017-07-05 |
WO2011139371A1 (en) | 2011-11-10 |
ES2740802T3 (en) | 2020-02-06 |
EP3144673A1 (en) | 2017-03-22 |
EP4219759A3 (en) | 2023-09-06 |
CN104673899A (en) | 2015-06-03 |
DK3144673T3 (en) | 2019-09-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG10201503534RA (en) | Monitoring health and disease status using clonotype profiles | |
EP2773584A4 (en) | Brake torque monitoring and health assessment | |
EP2812661A4 (en) | Frequency-adaptable structural health and usage monitoring system | |
HK1214356A1 (en) | Health diagnostic systems and methods | |
GB201101858D0 (en) | Health monitoring | |
EP2849635A4 (en) | PATIENT IN-TtHE-LOOP PARTICIPATORY CARE AND MONITORING | |
GB2480654B (en) | Monitoring handwashing | |
GB201008834D0 (en) | Monitoring changes in behaviour of a human subject | |
EP2895054A4 (en) | Mobile cardiac health monitoring | |
EP2888726A4 (en) | Wireless infant health monitor | |
GB201217109D0 (en) | Health pillow | |
EP2568901A4 (en) | Reflectance-facilitated ultrasound treatment and monitoring | |
ZA201206466B (en) | Extruded animal litters | |
EP2481033A4 (en) | Hygiene monitoring systems and methods | |
GB201007632D0 (en) | Slat monitoring system | |
PL2485026T3 (en) | Structural health monitoring system | |
HK1195736A1 (en) | Radioimmunoconjugates and their use | |
GB201008591D0 (en) | Respiration monitoring device | |
EP2578153A4 (en) | Audiometer and method thereof | |
ZA201103013B (en) | Dough extruders and methods | |
GB2477597B (en) | Disinfectant materials and methods | |
EP2651287A4 (en) | Monitoring volaemic condition in a human or animal subject | |
HK1180747A1 (en) | Floor roller and sash | |
GB201010315D0 (en) | Asset health monitoring | |
GB201014102D0 (en) | Patient compliance monitoring device - pharmaceuticals |