SG10201405158QA - High throughput genome sequencing on dna arrays - Google Patents
High throughput genome sequencing on dna arraysInfo
- Publication number
- SG10201405158QA SG10201405158QA SG10201405158QA SG10201405158QA SG10201405158QA SG 10201405158Q A SG10201405158Q A SG 10201405158QA SG 10201405158Q A SG10201405158Q A SG 10201405158QA SG 10201405158Q A SG10201405158Q A SG 10201405158QA SG 10201405158Q A SG10201405158Q A SG 10201405158QA
- Authority
- SG
- Singapore
- Prior art keywords
- high throughput
- genome sequencing
- dna arrays
- throughput genome
- arrays
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77641506P | 2006-02-24 | 2006-02-24 | |
US82196006P | 2006-08-10 | 2006-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201405158QA true SG10201405158QA (en) | 2014-10-30 |
Family
ID=40221917
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201405158QA SG10201405158QA (en) | 2006-02-24 | 2007-02-26 | High throughput genome sequencing on dna arrays |
SG201101319-0A SG170028A1 (en) | 2006-02-24 | 2007-02-26 | High throughput genome sequencing on dna arrays |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG201101319-0A SG170028A1 (en) | 2006-02-24 | 2007-02-26 | High throughput genome sequencing on dna arrays |
Country Status (2)
Country | Link |
---|---|
US (7) | US20090264299A1 (en) |
SG (2) | SG10201405158QA (en) |
Families Citing this family (240)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1791682B (en) * | 2003-02-26 | 2013-05-22 | 凯利达基因组股份有限公司 | Random array DNA analysis by hybridization |
EP2202322A1 (en) | 2003-10-31 | 2010-06-30 | AB Advanced Genetic Analysis Corporation | Methods for producing a paired tag from a nucleic acid sequence and methods of use thereof |
DK1907571T3 (en) | 2005-06-15 | 2017-08-21 | Complete Genomics Inc | NUCLEIC ACID ANALYSIS USING INCIDENTAL MIXTURES OF NON-OVERLAPPING FRAGMENTS |
US20070190542A1 (en) * | 2005-10-03 | 2007-08-16 | Ling Xinsheng S | Hybridization assisted nanopore sequencing |
US7960104B2 (en) | 2005-10-07 | 2011-06-14 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
SG10201405158QA (en) | 2006-02-24 | 2014-10-30 | Callida Genomics Inc | High throughput genome sequencing on dna arrays |
CA2643700A1 (en) | 2006-02-24 | 2007-11-22 | Callida Genomics, Inc. | High throughput genome sequencing on dna arrays |
US7910302B2 (en) | 2006-10-27 | 2011-03-22 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
US20080221832A1 (en) * | 2006-11-09 | 2008-09-11 | Complete Genomics, Inc. | Methods for computing positional base probabilities using experminentals base value distributions |
US20090111705A1 (en) * | 2006-11-09 | 2009-04-30 | Complete Genomics, Inc. | Selection of dna adaptor orientation by hybrid capture |
EP2201136B1 (en) | 2007-10-01 | 2017-12-06 | Nabsys 2.0 LLC | Nanopore sequencing by hybridization of probes to form ternary complexes and variable range alignment |
WO2009052214A2 (en) | 2007-10-15 | 2009-04-23 | Complete Genomics, Inc. | Sequence analysis using decorated nucleic acids |
US20090263872A1 (en) * | 2008-01-23 | 2009-10-22 | Complete Genomics Inc. | Methods and compositions for preventing bias in amplification and sequencing reactions |
US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
US7901890B2 (en) | 2007-11-05 | 2011-03-08 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation |
US8518640B2 (en) | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
US8617811B2 (en) | 2008-01-28 | 2013-12-31 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
US7897344B2 (en) | 2007-11-06 | 2011-03-01 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs |
DK2215209T3 (en) | 2007-10-30 | 2018-09-03 | Complete Genomics Inc | DEVICE FOR HIGH-THROUGHPUT SEQUENCE OF NUCLEIC ACIDS |
WO2009073629A2 (en) | 2007-11-29 | 2009-06-11 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
CN102016068A (en) | 2008-01-09 | 2011-04-13 | 生命科技公司 | Method of making a paired tag library for nucleic acid sequencing |
US9540637B2 (en) | 2008-01-09 | 2017-01-10 | Life Technologies Corporation | Nucleic acid adaptors and uses thereof |
WO2009132028A1 (en) * | 2008-04-21 | 2009-10-29 | Complete Genomics, Inc. | Array structures for nucleic acid detection |
AU2009242484B2 (en) | 2008-05-02 | 2012-08-16 | Epicentre Technologies Corporation | Selective 5' ligation tagging of RNA |
US9650668B2 (en) | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
JP5717634B2 (en) * | 2008-09-03 | 2015-05-13 | ナブシス, インコーポレイテッド | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluid channels |
US8262879B2 (en) | 2008-09-03 | 2012-09-11 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
EP2376517B1 (en) | 2008-10-24 | 2013-01-16 | Epicentre Technologies Corporation | Transposon end compositions and methods for modifying nucleic acids |
US9080211B2 (en) | 2008-10-24 | 2015-07-14 | Epicentre Technologies Corporation | Transposon end compositions and methods for modifying nucleic acids |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
EP2719774B8 (en) | 2008-11-07 | 2020-04-22 | Adaptive Biotechnologies Corporation | Methods of monitoring conditions by sequence analysis |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
DK3059337T3 (en) | 2009-01-15 | 2019-07-22 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and methods for producing monoclonal antibodies |
EP2394165A4 (en) * | 2009-02-03 | 2013-12-11 | Complete Genomics Inc | Oligomer sequences mapping |
EP2393944A4 (en) * | 2009-02-03 | 2013-11-27 | Complete Genomics Inc | Indexing a reference sequence for oligomer sequence mapping |
US8615365B2 (en) * | 2009-02-03 | 2013-12-24 | Complete Genomics, Inc. | Oligomer sequences mapping |
WO2010111605A2 (en) * | 2009-03-27 | 2010-09-30 | Nabsys, Inc. | Devices and methods for analyzing biomolecules and probes bound thereto |
US8455260B2 (en) * | 2009-03-27 | 2013-06-04 | Massachusetts Institute Of Technology | Tagged-fragment map assembly |
WO2010127045A2 (en) * | 2009-04-29 | 2010-11-04 | Complete Genomics, Inc. | Method and system for calling variations in a sample polynucleotide sequence with respect to a reference polynucleotide sequence |
US8246799B2 (en) * | 2009-05-28 | 2012-08-21 | Nabsys, Inc. | Devices and methods for analyzing biomolecules and probes bound thereto |
US9524369B2 (en) | 2009-06-15 | 2016-12-20 | Complete Genomics, Inc. | Processing and analysis of complex nucleic acid sequence data |
KR20120044941A (en) | 2009-06-25 | 2012-05-08 | 프레드 헛친슨 켄서 리서치 센터 | Method of measuring adaptive immunity |
US8895242B2 (en) * | 2009-10-20 | 2014-11-25 | The Regents Of The University Of California | Single molecule nucleic acid nanoparticles |
US9023769B2 (en) | 2009-11-30 | 2015-05-05 | Complete Genomics, Inc. | cDNA library for nucleic acid sequencing |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
PT2556171E (en) | 2010-04-05 | 2015-12-21 | Prognosys Biosciences Inc | Spatially encoded biological assays |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
US8774494B2 (en) | 2010-04-30 | 2014-07-08 | Complete Genomics, Inc. | Method and system for accurate alignment and registration of array for DNA sequencing |
US20120003657A1 (en) * | 2010-07-02 | 2012-01-05 | Samuel Myllykangas | Targeted sequencing library preparation by genomic dna circularization |
US9671344B2 (en) | 2010-08-31 | 2017-06-06 | Complete Genomics, Inc. | High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging |
US9880089B2 (en) | 2010-08-31 | 2018-01-30 | Complete Genomics, Inc. | High-density devices with synchronous tracks for quad-cell based alignment correction |
US8715933B2 (en) | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
KR101963462B1 (en) | 2010-10-04 | 2019-03-28 | 제납시스 인크. | Systems and methods for automated reusable parallel biological reactions |
US9184099B2 (en) | 2010-10-04 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biosensor devices, systems and methods therefor |
US9399217B2 (en) | 2010-10-04 | 2016-07-26 | Genapsys, Inc. | Chamber free nanoreactor system |
US8725422B2 (en) | 2010-10-13 | 2014-05-13 | Complete Genomics, Inc. | Methods for estimating genome-wide copy number variations |
US8859201B2 (en) | 2010-11-16 | 2014-10-14 | Nabsys, Inc. | Methods for sequencing a biomolecule by detecting relative positions of hybridized probes |
WO2012109574A2 (en) | 2011-02-11 | 2012-08-16 | Nabsys, Inc. | Assay methods using dna binding proteins |
WO2012135658A2 (en) * | 2011-03-30 | 2012-10-04 | Noblegen Biosciences, Inc. | Sequence preserved dna conversion for optical nanopore sequencing |
US20120258871A1 (en) | 2011-04-08 | 2012-10-11 | Prognosys Biosciences, Inc. | Peptide constructs and assay systems |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
US9926596B2 (en) | 2011-05-27 | 2018-03-27 | Genapsys, Inc. | Systems and methods for genetic and biological analysis |
US8585973B2 (en) | 2011-05-27 | 2013-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Nano-sensor array |
CA2841808A1 (en) | 2011-07-13 | 2013-01-17 | The Multiple Myeloma Research Foundation, Inc. | Methods for data collection and distribution |
US8880456B2 (en) * | 2011-08-25 | 2014-11-04 | Complete Genomics, Inc. | Analyzing genome sequencing information to determine likelihood of co-segregating alleles on haplotypes |
CA2848304A1 (en) | 2011-09-09 | 2013-03-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for sequencing a polynucleotide |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
HRP20211523T1 (en) | 2011-09-23 | 2021-12-24 | Illumina, Inc. | Compositions for nucleic acid sequencing |
US9279159B2 (en) | 2011-10-21 | 2016-03-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
US10837879B2 (en) | 2011-11-02 | 2020-11-17 | Complete Genomics, Inc. | Treatment for stabilizing nucleic acid arrays |
CN106591103B (en) | 2011-12-01 | 2021-06-04 | 吉纳普赛斯股份有限公司 | System and method for efficient electronic sequencing and detection |
EP3904536A1 (en) | 2011-12-09 | 2021-11-03 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
EP2823060B1 (en) | 2012-03-05 | 2018-02-14 | Adaptive Biotechnologies Corporation | Determining paired immune receptor chains from frequency matched subunits |
US9803239B2 (en) * | 2012-03-29 | 2017-10-31 | Complete Genomics, Inc. | Flow cells for high density array chips |
US20130261984A1 (en) | 2012-03-30 | 2013-10-03 | Illumina, Inc. | Methods and systems for determining fetal chromosomal abnormalities |
JP5756247B1 (en) | 2012-05-08 | 2015-07-29 | アダプティブ バイオテクノロジーズ コーポレイション | Composition and method for measuring and calibrating amplification bias in multiplex PCR reactions |
US9977861B2 (en) | 2012-07-18 | 2018-05-22 | Illumina Cambridge Limited | Methods and systems for determining haplotypes and phasing of haplotypes |
WO2014018675A1 (en) * | 2012-07-24 | 2014-01-30 | President And Fellows Of Harvard College | Self-assembly of nucleic acid nanostructures |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US9567631B2 (en) | 2012-12-14 | 2017-02-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
KR102090851B1 (en) | 2012-08-14 | 2020-03-19 | 10엑스 제노믹스, 인크. | Microcapsule compositions and methods |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
EP2904111B1 (en) | 2012-10-01 | 2017-12-06 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
WO2014071070A1 (en) | 2012-11-01 | 2014-05-08 | Pacific Biosciences Of California, Inc. | Compositions and methods for selection of nucleic acids |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9914966B1 (en) | 2012-12-20 | 2018-03-13 | Nabsys 2.0 Llc | Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation |
US10294516B2 (en) | 2013-01-18 | 2019-05-21 | Nabsys 2.0 Llc | Enhanced probe binding |
CN108753766A (en) | 2013-02-08 | 2018-11-06 | 10X基因组学有限公司 | Polynucleotides bar code generating at |
US9328382B2 (en) | 2013-03-15 | 2016-05-03 | Complete Genomics, Inc. | Multiple tagging of individual long DNA fragments |
WO2014152625A1 (en) * | 2013-03-15 | 2014-09-25 | Genapsys, Inc. | Systems and methods for biological analysis |
US9879313B2 (en) | 2013-06-25 | 2018-01-30 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
WO2015027245A1 (en) | 2013-08-23 | 2015-02-26 | Complete Genomics, Inc. | Long fragment de novo assembly using short reads |
US10395758B2 (en) | 2013-08-30 | 2019-08-27 | 10X Genomics, Inc. | Sequencing methods |
EP3049539B1 (en) | 2013-09-25 | 2018-09-05 | Bio-Id Diagnostic Inc. | Methods for detecting nucleic acid fragments |
US10125393B2 (en) | 2013-12-11 | 2018-11-13 | Genapsys, Inc. | Systems and methods for biological analysis and computation |
US9824068B2 (en) | 2013-12-16 | 2017-11-21 | 10X Genomics, Inc. | Methods and apparatus for sorting data |
GB201401885D0 (en) * | 2014-02-04 | 2014-03-19 | Olink Ab | Proximity assay with detection based on hybridisation chain reaction (HCR) |
CA2938669A1 (en) | 2014-02-04 | 2015-08-13 | Igenomx International Genomics Corporation | Genome fractioning |
WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
CN106413896B (en) | 2014-04-10 | 2019-07-05 | 10X基因组学有限公司 | For encapsulating and dividing fluid means, system and method and its application of reagent |
AU2015243238A1 (en) * | 2014-04-11 | 2016-10-27 | The Trustees Of The University Of Pennsylvania | Compositions and methods for metagenome biomarker detection |
US9822401B2 (en) | 2014-04-18 | 2017-11-21 | Genapsys, Inc. | Methods and systems for nucleic acid amplification |
CN106460069B (en) * | 2014-04-18 | 2021-02-12 | 威廉马歇莱思大学 | Competitive compositions for enriching nucleic acid molecules for rare allele-containing material |
EP3889325A1 (en) | 2014-06-26 | 2021-10-06 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
US10839939B2 (en) | 2014-06-26 | 2020-11-17 | 10X Genomics, Inc. | Processes and systems for nucleic acid sequence assembly |
KR101696259B1 (en) * | 2014-07-23 | 2017-01-13 | 나노바이오시스 주식회사 | Multiplex pcr chip and multiplex pcr device comprising the same |
GB201413718D0 (en) * | 2014-08-01 | 2014-09-17 | Olink Ab | Method for selecting a target nucleic acid sequence |
US10435685B2 (en) | 2014-08-19 | 2019-10-08 | Pacific Biosciences Of California, Inc. | Compositions and methods for enrichment of nucleic acids |
WO2016069886A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corporation | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
MX2017005267A (en) | 2014-10-29 | 2017-07-26 | 10X Genomics Inc | Methods and compositions for targeted nucleic acid sequencing. |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
US10954559B2 (en) | 2014-11-21 | 2021-03-23 | Mgi Tech Co., Ltd. | Bubble-shaped adaptor element and method of constructing sequencing library with bubble-shaped adaptor element |
EP3498866A1 (en) | 2014-11-25 | 2019-06-19 | Adaptive Biotechnologies Corp. | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
AU2016207023B2 (en) | 2015-01-12 | 2019-12-05 | 10X Genomics, Inc. | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
KR20170106979A (en) | 2015-01-13 | 2017-09-22 | 10엑스 제노믹스, 인크. | System and method for visualizing structure variation and phase adjustment information |
JP2018513445A (en) | 2015-02-09 | 2018-05-24 | 10エックス ゲノミクス,インコーポレイテッド | System and method for fading using structural variation identification and variant call data |
WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
EP3262188B1 (en) | 2015-02-24 | 2021-05-05 | 10X Genomics, Inc. | Methods for targeted nucleic acid sequence coverage |
WO2016137973A1 (en) | 2015-02-24 | 2016-09-01 | 10X Genomics Inc | Partition processing methods and systems |
US10968536B2 (en) | 2015-02-25 | 2021-04-06 | Jumpcode Genomics, Inc. | Methods and compositions for sequencing |
US11807896B2 (en) | 2015-03-26 | 2023-11-07 | Dovetail Genomics, Llc | Physical linkage preservation in DNA storage |
AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
CN113186256A (en) | 2015-04-10 | 2021-07-30 | 空间转录公司 | Spatially differentiated, multiplexed nucleic acid analysis of biological samples |
GB201506315D0 (en) * | 2015-04-14 | 2015-05-27 | Hypergenomics Pte Ltd | Method |
US11390914B2 (en) * | 2015-04-23 | 2022-07-19 | Becton, Dickinson And Company | Methods and compositions for whole transcriptome amplification |
GB201513128D0 (en) * | 2015-07-24 | 2015-09-09 | Sense Biodetection Ltd | Nucleic acid detection method |
US11371094B2 (en) | 2015-11-19 | 2022-06-28 | 10X Genomics, Inc. | Systems and methods for nucleic acid processing using degenerate nucleotides |
JP6954899B2 (en) | 2015-12-04 | 2021-10-27 | 10エックス ゲノミクス,インコーポレイテッド | Methods and compositions for nucleic acid analysis |
JP6735348B2 (en) | 2016-02-11 | 2020-08-05 | 10エックス ジェノミクス, インコーポレイテッド | Systems, methods and media for de novo assembly of whole genome sequence data |
US11339427B2 (en) | 2016-02-12 | 2022-05-24 | Jumpcode Genomics, Inc. | Method for target specific RNA transcription of DNA sequences |
JP6584986B2 (en) | 2016-03-18 | 2019-10-02 | 株式会社東芝 | Nucleic acid detection method |
WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
WO2017197300A1 (en) * | 2016-05-13 | 2017-11-16 | Dovetail Genomics Llc | Recovering long-range linkage information from preserved samples |
US20170342463A1 (en) * | 2016-05-25 | 2017-11-30 | Bio-Rad Laboratories, Inc. | Digital proximity assay |
US11352667B2 (en) | 2016-06-21 | 2022-06-07 | 10X Genomics, Inc. | Nucleic acid sequencing |
CN116397014A (en) | 2016-07-20 | 2023-07-07 | 测序健康公司 | Systems and methods for nucleic acid sequencing |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
JP7053587B2 (en) | 2016-09-27 | 2022-04-12 | イラミーナ インコーポレーテッド | Imprint board |
US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
EP4112741A1 (en) | 2017-01-04 | 2023-01-04 | MGI Tech Co., Ltd. | Stepwise sequencing by non-labeled reversible terminators or natural nucleotides |
WO2018140966A1 (en) | 2017-01-30 | 2018-08-02 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
US10995333B2 (en) | 2017-02-06 | 2021-05-04 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
CN110050073A (en) * | 2017-03-14 | 2019-07-23 | 香港科技大学 | The determination method of haplotype and double type |
CN110870018A (en) | 2017-05-19 | 2020-03-06 | 10X基因组学有限公司 | System and method for analyzing a data set |
US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
CN109526228B (en) | 2017-05-26 | 2022-11-25 | 10X基因组学有限公司 | Single cell analysis of transposase accessible chromatin |
WO2018222941A1 (en) * | 2017-06-01 | 2018-12-06 | Counsyl, Inc. | Preparation of concatenated polynucleotides |
EP3655572A4 (en) * | 2017-07-17 | 2021-03-24 | Seqonce Biosciences, Inc. | Rapid library construction for high throughput sequencing |
EP3684951A4 (en) | 2017-09-21 | 2021-06-16 | Genapsys, Inc. | Systems and methods for nucleic acid sequencing |
US10837047B2 (en) | 2017-10-04 | 2020-11-17 | 10X Genomics, Inc. | Compositions, methods, and systems for bead formation using improved polymers |
WO2019081483A1 (en) * | 2017-10-23 | 2019-05-02 | Base4 Innovation Limited | Single nucleotide analytical method and associated probes |
WO2019084043A1 (en) | 2017-10-26 | 2019-05-02 | 10X Genomics, Inc. | Methods and systems for nuclecic acid preparation and chromatin analysis |
CN111479631B (en) | 2017-10-27 | 2022-02-22 | 10X基因组学有限公司 | Methods and systems for sample preparation and analysis |
JP7019200B2 (en) | 2017-11-13 | 2022-02-15 | ザ マルチプル ミエローマ リサーチ ファウンデーション, インコーポレイテッド | An integrated molecular, omics, immunotherapy, metabolic, epigenetic, and clinical database |
SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
WO2019108851A1 (en) | 2017-11-30 | 2019-06-06 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation and analysis |
WO2019157529A1 (en) | 2018-02-12 | 2019-08-15 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
US11639928B2 (en) | 2018-02-22 | 2023-05-02 | 10X Genomics, Inc. | Methods and systems for characterizing analytes from individual cells or cell populations |
EP3775271A1 (en) | 2018-04-06 | 2021-02-17 | 10X Genomics, Inc. | Systems and methods for quality control in single cell processing |
US20210102194A1 (en) | 2018-06-04 | 2021-04-08 | Illumina, Inc. | High-throughput single-cell transcriptome libraries and methods of making and of using |
US11932899B2 (en) | 2018-06-07 | 2024-03-19 | 10X Genomics, Inc. | Methods and systems for characterizing nucleic acid molecules |
US11703427B2 (en) | 2018-06-25 | 2023-07-18 | 10X Genomics, Inc. | Methods and systems for cell and bead processing |
US20200032335A1 (en) | 2018-07-27 | 2020-01-30 | 10X Genomics, Inc. | Systems and methods for metabolome analysis |
US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
KR20210086644A (en) * | 2018-10-31 | 2021-07-08 | 럿거스, 더 스테이트 유니버시티 오브 뉴 저지 | GRAMC: Genome Scale Reporter Analysis Method for CIS Regulatory Module |
US11459607B1 (en) | 2018-12-10 | 2022-10-04 | 10X Genomics, Inc. | Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11845983B1 (en) | 2019-01-09 | 2023-12-19 | 10X Genomics, Inc. | Methods and systems for multiplexing of droplet based assays |
CA3125496A1 (en) * | 2019-01-28 | 2020-08-06 | Bgi Shenzhen | Sequencing chip and manufacturing mehtod therefor |
US11851683B1 (en) | 2019-02-12 | 2023-12-26 | 10X Genomics, Inc. | Methods and systems for selective analysis of cellular samples |
WO2020168013A1 (en) | 2019-02-12 | 2020-08-20 | 10X Genomics, Inc. | Methods for processing nucleic acid molecules |
US11467153B2 (en) | 2019-02-12 | 2022-10-11 | 10X Genomics, Inc. | Methods for processing nucleic acid molecules |
US11655499B1 (en) | 2019-02-25 | 2023-05-23 | 10X Genomics, Inc. | Detection of sequence elements in nucleic acid molecules |
US20220033805A1 (en) | 2019-03-01 | 2022-02-03 | Sanjay Srivatsan | High-throughput single-nuclei and single-cell libraries and methods of making and of using |
WO2020185791A1 (en) | 2019-03-11 | 2020-09-17 | 10X Genomics, Inc. | Systems and methods for processing optically tagged beads |
MX2021003760A (en) | 2019-04-29 | 2021-09-21 | Illumina Inc | Identification and analysis of microbial samples by rapid incubation and nucleic acid enrichment. |
WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
US20220333186A1 (en) * | 2019-09-26 | 2022-10-20 | Jumpcode Genomics, Inc. | Method and system for targeted nucleic acid sequencing |
EP4025711A2 (en) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
EP4078151A4 (en) | 2019-12-17 | 2024-01-03 | Applied Materials Inc | System and method for acquisition and processing of multiplexed fluorescence in-situ hybridization images |
MX2021011847A (en) | 2019-12-19 | 2021-11-17 | Illumina Inc | High-throughput single-cell libraries and methods of making and of using. |
FI3891300T3 (en) | 2019-12-23 | 2023-05-10 | 10X Genomics Inc | Methods for spatial analysis using rna-templated ligation |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
KR20220148196A (en) * | 2020-02-10 | 2022-11-04 | 팔로젠 인코포레이티드 | Nanopore device and method for detecting and classifying charged particles using same |
US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
ES2965354T3 (en) | 2020-04-22 | 2024-04-12 | 10X Genomics Inc | Methods for spatial analysis using targeted RNA deletion |
US11851700B1 (en) | 2020-05-13 | 2023-12-26 | 10X Genomics, Inc. | Methods, kits, and compositions for processing extracellular molecules |
AU2021275906A1 (en) | 2020-05-22 | 2022-12-22 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
CN116249785A (en) | 2020-06-02 | 2023-06-09 | 10X基因组学有限公司 | Space transcriptomics for antigen-receptor |
EP4025692A2 (en) | 2020-06-02 | 2022-07-13 | 10X Genomics, Inc. | Nucleic acid library methods |
WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
WO2021252617A1 (en) | 2020-06-09 | 2021-12-16 | Illumina, Inc. | Methods for increasing yield of sequencing libraries |
EP4165207A1 (en) | 2020-06-10 | 2023-04-19 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
WO2021258024A1 (en) * | 2020-06-19 | 2021-12-23 | California Institute Of Technology | Sensitive and multiplexed detection of nucleic acids and proteins for large scale serological testing |
AU2021294334A1 (en) | 2020-06-25 | 2023-02-02 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
WO2022140028A1 (en) | 2020-12-21 | 2022-06-30 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
WO2022182682A1 (en) | 2021-02-23 | 2022-09-01 | 10X Genomics, Inc. | Probe-based analysis of nucleic acids and proteins |
EP4301870A1 (en) | 2021-03-18 | 2024-01-10 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
US20220336052A1 (en) * | 2021-04-19 | 2022-10-20 | University Of Utah Research Foundation | Systems and methods for facilitating rapid genome sequence analysis |
US11859241B2 (en) | 2021-06-17 | 2024-01-02 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
US11220707B1 (en) | 2021-06-17 | 2022-01-11 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
WO2023034489A1 (en) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
WO2023086335A2 (en) * | 2021-11-12 | 2023-05-19 | Chan Zuckerberg Biohub, Inc. | Method for massively-parallel screening of aptamer switches |
AU2023248405A1 (en) | 2022-04-07 | 2024-01-04 | Illumina, Inc. | Altered cytidine deaminases and methods of use |
WO2024073047A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Cytidine deaminases and methods of use in mapping modified cytosine nucleotides |
WO2024073043A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Methods of using cpg binding proteins in mapping modified cytosine nucleotides |
WO2024069581A1 (en) | 2022-09-30 | 2024-04-04 | Illumina Singapore Pte. Ltd. | Helicase-cytidine deaminase complexes and methods of use |
Family Cites Families (183)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4318846A (en) * | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
US4994373A (en) * | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
US4605735A (en) * | 1983-02-14 | 1986-08-12 | Wakunaga Seiyaku Kabushiki Kaisha | Oligonucleotide derivatives |
US4719179A (en) * | 1984-11-30 | 1988-01-12 | Pharmacia P-L Biochemicals, Inc. | Six base oligonucleotide linkers and methods for their use |
US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
US5235033A (en) * | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
US4757141A (en) * | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
US5091519A (en) * | 1986-05-01 | 1992-02-25 | Amoco Corporation | Nucleotide compositions with linking groups |
US5151507A (en) * | 1986-07-02 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
US5202231A (en) * | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US5525464A (en) * | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
US4886741A (en) | 1987-12-09 | 1989-12-12 | Microprobe Corporation | Use of volume exclusion agents for the enhancement of in situ hybridization |
US5354657A (en) | 1988-01-12 | 1994-10-11 | Boehringer Mannheim Gmbh | Process for the highly specific detection of nucleic acids in solid |
DE3813278A1 (en) | 1988-01-12 | 1989-07-20 | Boehringer Mannheim Gmbh | METHOD FOR DETECTING NUCLEIC ACIDS |
US5216141A (en) * | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
US5066580A (en) | 1988-08-31 | 1991-11-19 | Becton Dickinson And Company | Xanthene dyes that emit to the red of fluorescein |
DE3836656A1 (en) * | 1988-10-27 | 1990-05-03 | Boehringer Mannheim Gmbh | NEW DIGOXIGENINE DERIVATIVES AND THEIR USE |
US5091302A (en) * | 1989-04-27 | 1992-02-25 | The Blood Center Of Southeastern Wisconsin, Inc. | Polymorphism of human platelet membrane glycoprotein iiia and diagnostic and therapeutic applications thereof |
US6379895B1 (en) * | 1989-06-07 | 2002-04-30 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US6346413B1 (en) * | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
US5188934A (en) * | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
US5427930A (en) * | 1990-01-26 | 1995-06-27 | Abbott Laboratories | Amplification of target nucleic acids using gap filling ligase chain reaction |
CA2036946C (en) * | 1990-04-06 | 2001-10-16 | Kenneth V. Deugau | Indexing linkers |
GB9009980D0 (en) | 1990-05-03 | 1990-06-27 | Amersham Int Plc | Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides |
WO1992001813A1 (en) * | 1990-07-25 | 1992-02-06 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
US5386023A (en) * | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
US5602240A (en) * | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
US5426180A (en) * | 1991-03-27 | 1995-06-20 | Research Corporation Technologies, Inc. | Methods of making single-stranded circular oligonucleotides |
US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US6589726B1 (en) * | 1991-09-04 | 2003-07-08 | Metrigen, Inc. | Method and apparatus for in situ synthesis on a solid support |
DE69233719T2 (en) * | 1991-09-24 | 2009-01-02 | Keygene N.V. | Primers, sets and restriction fragments and their use in selective restriction fragment amplification |
US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US5644048A (en) * | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
US5403708A (en) * | 1992-07-06 | 1995-04-04 | Brennan; Thomas M. | Methods and compositions for determining the sequence of nucleic acids |
GB9214873D0 (en) * | 1992-07-13 | 1992-08-26 | Medical Res Council | Process for categorising nucleotide sequence populations |
US5834202A (en) * | 1992-08-04 | 1998-11-10 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
WO1994003624A1 (en) | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
US6261808B1 (en) * | 1992-08-04 | 2001-07-17 | Replicon, Inc. | Amplification of nucleic acid molecules via circular replicons |
US6096880A (en) * | 1993-04-15 | 2000-08-01 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
US5714320A (en) * | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
US6077668A (en) * | 1993-04-15 | 2000-06-20 | University Of Rochester | Highly sensitive multimeric nucleic acid probes |
DE69400631T2 (en) * | 1993-05-05 | 1997-02-27 | Palo Alto Medical Found | USE OF RIFAMYCINE DERIVATIVES FOR PRODUCING A MEDICINAL PRODUCT FOR TREATING TOXOPLASMOSIS |
US5406708A (en) * | 1993-05-06 | 1995-04-18 | Stephens; Lyle G. | Flexible rotating vegetation cutter |
EP0706531A4 (en) | 1993-07-02 | 1998-11-25 | Lynx Therapeutics Inc | Synthesis of branched nucleic acids |
US5473060A (en) | 1993-07-02 | 1995-12-05 | Lynx Therapeutics, Inc. | Oligonucleotide clamps having diagnostic applications |
ATE257861T1 (en) | 1993-09-27 | 2004-01-15 | Arch Dev Corp | METHODS AND COMPOSITIONS FOR EFFICIENT NUCLIC ACID SEQUENCING |
US6401267B1 (en) * | 1993-09-27 | 2002-06-11 | Radoje Drmanac | Methods and compositions for efficient nucleic acid sequencing |
US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
SE9400522D0 (en) * | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
US5637684A (en) * | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
US5641658A (en) * | 1994-08-03 | 1997-06-24 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid with two primers bound to a single solid support |
US5710000A (en) * | 1994-09-16 | 1998-01-20 | Affymetrix, Inc. | Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping |
US6654505B2 (en) | 1994-10-13 | 2003-11-25 | Lynx Therapeutics, Inc. | System and apparatus for sequential processing of analytes |
US6013445A (en) * | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
FR2726286B1 (en) * | 1994-10-28 | 1997-01-17 | Genset Sa | SOLID PHASE NUCLEIC ACID AMPLIFICATION PROCESS AND REAGENT KIT USEFUL FOR CARRYING OUT SAID PROCESS |
US5866337A (en) * | 1995-03-24 | 1999-02-02 | The Trustees Of Columbia University In The City Of New York | Method to detect mutations in a nucleic acid using a hybridization-ligation procedure |
US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
US5648245A (en) * | 1995-05-09 | 1997-07-15 | Carnegie Institution Of Washington | Method for constructing an oligonucleotide concatamer library by rolling circle replication |
EP0824684B1 (en) | 1995-05-12 | 2007-11-07 | Novartis AG | Method for the parallel detection of a plurality of analytes using evanescently excited luminescence |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
DK0862656T3 (en) | 1995-11-21 | 2001-04-09 | Univ Yale | Unimolecular segment amplification and detection |
DE69636080T2 (en) * | 1995-12-05 | 2006-11-30 | Erland Jorn Koch | A cascading amplification reaction of nucleic acids |
US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
US5847162A (en) | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
US5851804A (en) | 1996-05-06 | 1998-12-22 | Apollon, Inc. | Chimeric kanamycin resistance gene |
US5869245A (en) * | 1996-06-05 | 1999-02-09 | Fox Chase Cancer Center | Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands |
GB9620209D0 (en) * | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
US5916750A (en) * | 1997-01-08 | 1999-06-29 | Biogenex Laboratories | Multifunctional linking reagents for synthesis of branched oligomers |
US6297006B1 (en) | 1997-01-16 | 2001-10-02 | Hyseq, Inc. | Methods for sequencing repetitive sequences and for determining the order of sequence subfragments |
US6309824B1 (en) | 1997-01-16 | 2001-10-30 | Hyseq, Inc. | Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes |
US5994068A (en) | 1997-03-11 | 1999-11-30 | Wisconsin Alumni Research Foundation | Nucleic acid indexing |
ATE269908T1 (en) * | 1997-04-01 | 2004-07-15 | Manteia S A | METHOD FOR SEQUENCING NUCLEIC ACIDS |
US5888737A (en) | 1997-04-15 | 1999-03-30 | Lynx Therapeutics, Inc. | Adaptor-based sequence analysis |
US20040229221A1 (en) | 1997-05-08 | 2004-11-18 | Trustees Of Columbia University In The City Of New York | Method to detect mutations in a nucleic acid using a hybridization-ligation procedure |
ATE487790T1 (en) | 1997-07-07 | 2010-11-15 | Medical Res Council | IN VITRO SORTING PROCESS |
US6124120A (en) * | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
CA2305449A1 (en) * | 1997-10-10 | 1999-04-22 | President & Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
US6207392B1 (en) * | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6136537A (en) | 1998-02-23 | 2000-10-24 | Macevicz; Stephen C. | Gene expression analysis |
AU3601599A (en) * | 1998-03-25 | 1999-10-18 | Ulf Landegren | Rolling circle replication of padlock probes |
US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
US6284497B1 (en) * | 1998-04-09 | 2001-09-04 | Trustees Of Boston University | Nucleic acid arrays and methods of synthesis |
US6255469B1 (en) * | 1998-05-06 | 2001-07-03 | New York University | Periodic two and three dimensional nucleic acid structures |
WO2000004193A1 (en) | 1998-07-20 | 2000-01-27 | Yale University | Method for detecting nucleic acids using target-mediated ligation of bipartite primers |
JP2002521064A (en) * | 1998-07-30 | 2002-07-16 | ソレックサ リミテッド | Array biomolecules and their use in sequencing |
US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
US6232067B1 (en) * | 1998-08-17 | 2001-05-15 | The Perkin-Elmer Corporation | Adapter directed expression analysis |
US6653077B1 (en) | 1998-09-04 | 2003-11-25 | Lynx Therapeutics, Inc. | Method of screening for genetic polymorphism |
WO2000015779A2 (en) | 1998-09-15 | 2000-03-23 | Yale University | Molecular cloning using rolling circle amplification |
US6326144B1 (en) | 1998-09-18 | 2001-12-04 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
US6235502B1 (en) * | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
US6426513B1 (en) * | 1998-09-18 | 2002-07-30 | Massachusetts Institute Of Technology | Water-soluble thiol-capped nanocrystals |
US6251303B1 (en) | 1998-09-18 | 2001-06-26 | Massachusetts Institute Of Technology | Water-soluble fluorescent nanocrystals |
CA2356697C (en) * | 1999-01-06 | 2010-06-22 | Cornell Research Foundation, Inc. | Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing |
WO2000040758A2 (en) | 1999-01-06 | 2000-07-13 | Hyseq Inc. | Enhanced sequencing by hybridization using pools of probes |
GB9901475D0 (en) | 1999-01-22 | 1999-03-17 | Pyrosequencing Ab | A method of DNA sequencing |
US6514768B1 (en) * | 1999-01-29 | 2003-02-04 | Surmodics, Inc. | Replicable probe array |
AU4701200A (en) * | 1999-05-07 | 2000-11-21 | Quantum Dot Corporation | A method of detecting an analyte using semiconductor nanocrystals |
EP2360270B1 (en) | 1999-05-20 | 2016-11-09 | Illumina, Inc. | Combinatorial decoding of random nucleic acid arrays |
US6573369B2 (en) * | 1999-05-21 | 2003-06-03 | Bioforce Nanosciences, Inc. | Method and apparatus for solid state molecular analysis |
US7501245B2 (en) | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US6472156B1 (en) | 1999-08-30 | 2002-10-29 | The University Of Utah | Homogeneous multiplex hybridization analysis by color and Tm |
US6274320B1 (en) * | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
US7244559B2 (en) * | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
EP1218543A2 (en) | 1999-09-29 | 2002-07-03 | Solexa Ltd. | Polynucleotide sequencing |
US6302263B1 (en) * | 1999-10-08 | 2001-10-16 | Ecolab, Inc. | Apparatus and method for the controlled lubrication and cleaning of conveyors |
US6297016B1 (en) | 1999-10-08 | 2001-10-02 | Applera Corporation | Template-dependent ligation with PNA-DNA chimeric probes |
JP2003532380A (en) | 1999-12-02 | 2003-11-05 | モレキュラー ステージング,インコーポレイテッド | Production of single-stranded circular DNA from linear self-annealing segments |
JP4860869B2 (en) | 1999-12-29 | 2012-01-25 | オックスフォード ジーン テクノロジー アイピー リミティド | Method for amplifying and detecting a plurality of polynucleotides on a solid support |
GB0002389D0 (en) * | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
US6221603B1 (en) * | 2000-02-04 | 2001-04-24 | Molecular Dynamics, Inc. | Rolling circle amplification assay for nucleic acid analysis |
US6913884B2 (en) * | 2001-08-16 | 2005-07-05 | Illumina, Inc. | Compositions and methods for repetitive use of genomic DNA |
WO2001057268A2 (en) | 2000-02-07 | 2001-08-09 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
AU2001238068A1 (en) * | 2000-02-07 | 2001-08-14 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
AU2001241723A1 (en) | 2000-02-25 | 2001-09-03 | Affymetrix, Inc. | Methods for multi-stage solid phase amplification of nucleic acids |
WO2001064831A1 (en) * | 2000-02-29 | 2001-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Microarray substrate with integrated photodetector and methods of use thereof |
US6413722B1 (en) * | 2000-03-22 | 2002-07-02 | Incyte Genomics, Inc. | Polymer coated surfaces for microarray applications |
US6649138B2 (en) | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
US6576291B2 (en) * | 2000-12-08 | 2003-06-10 | Massachusetts Institute Of Technology | Preparation of nanocrystallites |
US6783943B2 (en) * | 2000-12-20 | 2004-08-31 | The Regents Of The University Of California | Rolling circle amplification detection of RNA and DNA |
EP2801624B1 (en) | 2001-03-16 | 2019-03-06 | Singular Bio, Inc | Arrays and methods of use |
ATE556845T1 (en) | 2001-07-20 | 2012-05-15 | Life Technologies Corp | LUMINESCENT NANOPARTICLES AND THEIR PRODUCTION |
US7297778B2 (en) | 2001-07-25 | 2007-11-20 | Affymetrix, Inc. | Complexity management of genomic DNA |
GB2378245A (en) | 2001-08-03 | 2003-02-05 | Mats Nilsson | Nucleic acid amplification method |
GB2382137A (en) * | 2001-11-20 | 2003-05-21 | Mats Gullberg | Nucleic acid enrichment |
US7011945B2 (en) * | 2001-12-21 | 2006-03-14 | Eastman Kodak Company | Random array of micro-spheres for the analysis of nucleic acids |
US20040002090A1 (en) * | 2002-03-05 | 2004-01-01 | Pascal Mayer | Methods for detecting genome-wide sequence variations associated with a phenotype |
DE10224339A1 (en) | 2002-05-29 | 2003-12-11 | Axaron Bioscience Ag | Method for highly parallel nucleic acid sequencing |
AUPS298102A0 (en) | 2002-06-13 | 2002-07-04 | Nucleics Pty Ltd | Method for performing chemical reactions |
US20050019776A1 (en) * | 2002-06-28 | 2005-01-27 | Callow Matthew James | Universal selective genome amplification and universal genotyping system |
WO2004027093A1 (en) | 2002-09-19 | 2004-04-01 | The Chancellor, Master And Scholars Of The University Of Oxford | Molecular arrays and single molecule detection |
US7459273B2 (en) * | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
AU2003302770B2 (en) | 2002-12-20 | 2007-07-12 | Caliper Life Sciences, Inc. | Single molecule amplification and detection of DNA |
US6977153B2 (en) | 2002-12-31 | 2005-12-20 | Qiagen Gmbh | Rolling circle amplification of RNA |
DE602004024034D1 (en) * | 2003-01-29 | 2009-12-24 | 454 Corp | NUCLEIC ACID AMPLIFICATION BASED ON KINGGEL EMULSION |
US20060147935A1 (en) | 2003-02-12 | 2006-07-06 | Sten Linnarsson | Methods and means for nucleic acid sequencing |
CN1791682B (en) | 2003-02-26 | 2013-05-22 | 凯利达基因组股份有限公司 | Random array DNA analysis by hybridization |
US8222005B2 (en) * | 2003-09-17 | 2012-07-17 | Agency For Science, Technology And Research | Method for gene identification signature (GIS) analysis |
US20050100939A1 (en) * | 2003-09-18 | 2005-05-12 | Eugeni Namsaraev | System and methods for enhancing signal-to-noise ratios of microarray-based measurements |
GB0324456D0 (en) | 2003-10-20 | 2003-11-19 | Isis Innovation | Parallel DNA sequencing methods |
EP2202322A1 (en) * | 2003-10-31 | 2010-06-30 | AB Advanced Genetic Analysis Corporation | Methods for producing a paired tag from a nucleic acid sequence and methods of use thereof |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
EP1735458B1 (en) | 2004-01-28 | 2013-07-24 | 454 Life Sciences Corporation | Nucleic acid amplification with continuous flow emulsion |
GB0402895D0 (en) | 2004-02-10 | 2004-03-17 | Solexa Ltd | Arrayed polynucleotides |
CA2557177A1 (en) | 2004-02-19 | 2005-09-01 | Stephen Quake | Methods and kits for analyzing polynucleotide sequences |
CA2557841A1 (en) | 2004-02-27 | 2005-09-09 | President And Fellows Of Harvard College | Polony fluorescent in situ sequencing beads |
US20050214840A1 (en) | 2004-03-23 | 2005-09-29 | Xiangning Chen | Restriction enzyme mediated method of multiplex genotyping |
GB2413796B (en) | 2004-03-25 | 2006-03-29 | Global Genomics Ab | Methods and means for nucleic acid sequencing |
US20050260609A1 (en) | 2004-05-24 | 2005-11-24 | Lapidus Stanley N | Methods and devices for sequencing nucleic acids |
CA2566806A1 (en) | 2004-05-25 | 2006-01-19 | Helicos Biosciences Corporation | Methods and devices for nucleic acid sequence determination |
US20070117104A1 (en) | 2005-11-22 | 2007-05-24 | Buzby Philip R | Nucleotide analogs |
US20060024711A1 (en) * | 2004-07-02 | 2006-02-02 | Helicos Biosciences Corporation | Methods for nucleic acid amplification and sequence determination |
US7276720B2 (en) | 2004-07-19 | 2007-10-02 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
US20060012793A1 (en) * | 2004-07-19 | 2006-01-19 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
WO2006073504A2 (en) | 2004-08-04 | 2006-07-13 | President And Fellows Of Harvard College | Wobble sequencing |
GB0422551D0 (en) | 2004-10-11 | 2004-11-10 | Univ Liverpool | Labelling and sequencing of nucleic acids |
EP1817572A2 (en) | 2004-11-16 | 2007-08-15 | Helicos Biosciences Corporation | An optical train and method for tirf single molecule detection and analysis |
JP2008526877A (en) | 2005-01-05 | 2008-07-24 | エージェンコート パーソナル ジェノミクス | Reversible nucleotide terminator and use thereof |
EP2003214B1 (en) | 2005-02-01 | 2013-04-10 | AB Advanced Genetic Analysis Corporation | Reagents, methods, and libraries for bead-based sequencing |
DK1907571T3 (en) * | 2005-06-15 | 2017-08-21 | Complete Genomics Inc | NUCLEIC ACID ANALYSIS USING INCIDENTAL MIXTURES OF NON-OVERLAPPING FRAGMENTS |
WO2007014397A2 (en) | 2005-07-28 | 2007-02-01 | Helicos Biosciences Corporation | Consecutive base single molecule sequencing |
US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
US7960104B2 (en) * | 2005-10-07 | 2011-06-14 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
US7544473B2 (en) * | 2006-01-23 | 2009-06-09 | Population Genetics Technologies Ltd. | Nucleic acid analysis using sequence tokens |
WO2007092538A2 (en) * | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
CA2643700A1 (en) * | 2006-02-24 | 2007-11-22 | Callida Genomics, Inc. | High throughput genome sequencing on dna arrays |
SG10201405158QA (en) * | 2006-02-24 | 2014-10-30 | Callida Genomics Inc | High throughput genome sequencing on dna arrays |
US7910302B2 (en) * | 2006-10-27 | 2011-03-22 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
US20090111705A1 (en) * | 2006-11-09 | 2009-04-30 | Complete Genomics, Inc. | Selection of dna adaptor orientation by hybrid capture |
US7901890B2 (en) | 2007-11-05 | 2011-03-08 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation |
US7897344B2 (en) * | 2007-11-06 | 2011-03-01 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs |
-
2007
- 2007-02-26 SG SG10201405158QA patent/SG10201405158QA/en unknown
- 2007-02-26 US US11/679,124 patent/US20090264299A1/en not_active Abandoned
- 2007-02-26 SG SG201101319-0A patent/SG170028A1/en unknown
- 2007-10-31 US US11/981,761 patent/US8440397B2/en active Active
- 2007-10-31 US US11/981,605 patent/US9476054B2/en active Active
- 2007-10-31 US US11/981,804 patent/US20120135893A1/en not_active Abandoned
- 2007-10-31 US US11/981,793 patent/US20090118488A1/en not_active Abandoned
-
2016
- 2016-09-16 US US15/267,514 patent/US20170226577A1/en not_active Abandoned
-
2018
- 2018-03-29 US US15/940,771 patent/US20190010542A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8440397B2 (en) | 2013-05-14 |
US20090155781A1 (en) | 2009-06-18 |
US20190010542A1 (en) | 2019-01-10 |
US20120135893A1 (en) | 2012-05-31 |
US20170226577A1 (en) | 2017-08-10 |
US20090011943A1 (en) | 2009-01-08 |
US20090264299A1 (en) | 2009-10-22 |
US20090118488A1 (en) | 2009-05-07 |
US9476054B2 (en) | 2016-10-25 |
SG170028A1 (en) | 2011-04-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL238895A0 (en) | High throughput genome sequencing on dna arrays | |
SG10201405158QA (en) | High throughput genome sequencing on dna arrays | |
HRP20181833T1 (en) | Protein expression from multiple nucleic acids | |
HK1143188A1 (en) | High throughput nucleic acid sequencing by expansion | |
HK1216764A1 (en) | Apparatus for high throughput sequencing of nucleic acids | |
EP2201021A4 (en) | Alternative nucleic acid sequencing methods | |
HK1149298A1 (en) | Methods for nucleic acid sequencing | |
EP1731525A4 (en) | Nucleotide derivatives and dna microarray | |
EP1999276A4 (en) | Methods and means for nucleic acid sequencing | |
EP2173872A4 (en) | Copy dna and sense rna | |
EP1991694A4 (en) | Element-tagged oligonucleotide gene expression analysis | |
GB0619182D0 (en) | Oligonucleotide arrays | |
GB2445441B (en) | Nucleic acid purification method | |
EP2126072A4 (en) | Materials and methods for single molecule nucleic acid sequencing | |
IL181410A0 (en) | Process for plasmid dna fermentation | |
GB0603160D0 (en) | Nucleic acid | |
EP1996730A4 (en) | Small rna purification | |
GB0717591D0 (en) | Nucleic acid purification method | |
EP2134737A4 (en) | Functional nucleic acids for biological sequestration | |
GB0406863D0 (en) | Nucleic acid sequencing | |
EP2151495A4 (en) | Hcv gene | |
IL186142A0 (en) | Gene sythesis using pooled dna | |
EP2002020A4 (en) | Single nucleotide polymorphism detection from unamplified genomic dna | |
ZA200901744B (en) | Oligonucleotides for discriminating related nucleic acid sequences | |
GB0816745D0 (en) | Normalization probes for comparative genome hybridization arrays |