RU2334522C1 - Medicinal and preventive elixir for oral cavity care - Google Patents

Abstract

FIELD: medicine, stomatology.

SUBSTANCE: medicinal and preventive elixir for oral cavity care contains alcohol, surface-active substance, glycerin, perfume, biologically active additive with chloroform extract of herbs, i.e. nettle, plantain, myrrh, flowers of chamomile and calendula, Vitamin 'A', sodium fluoride, anion-active SAS, antiseptic, as preservative - nipagin, nipasol, perfume, colouring agent.

EFFECT: prolonged biological activity, anti-inflammatory capacity and expressed desensitising property.

2 cl, 4 ex

Description

The invention relates to dentistry, namely to means for the care of teeth, oral cavity and mouthwash.

Treatment and prophylactic agents for the treatment of oral diseases are aqueous or aqueous-alcoholic solutions of various substances useful for the oral cavity - essential oils, vitamins, antimicrobial substances, special anti-caries and anti-inflammatory components, astringents and flavorings. Unlike toothpastes, tooth elixirs do not contain abrasive and polishing substances and are recommended mainly as an auxiliary hygiene product. Dental elixirs are indispensable for hygienic care of the oral cavity with very loose teeth. Depending on the type of useful additives introduced into the composition of the elixir and their properties, elixirs can be hygienic and therapeutic. Dental elixirs are convenient to use, have no contraindications, quickly give a cleansing, deodorizing and refreshing effect, have anti-inflammatory properties.

Known drug for the treatment and prevention of gingivitis "Corsodil" containing a stabilized 0.2% solution of chlorhexidine bigluconate [1].

The disadvantage of this drug is that when rinsing along with periodontopathogenic flora under the influence of such a powerful antiseptic as a 0.2% solution of chlorhexidine bigluconate, the conditionally pathogenic microflora of the oral cavity is removed, and the immunoresistance of soft tissues of the oral cavity and periodontal tissues decreases.

Known dental elixir, as the main active ingredients containing vitamin B ₁ and sodium fluoride, which has high cleansing, deodorizing and antimicrobial properties [2]. Elixir is recommended as a hygiene product that helps to reduce dental caries. It is used in the form of mouth rinses with an elixir aqueous solution at the rate of 20 drops per 0.5 cup of water 2-3 times a day.

The disadvantage of the composition of this elixir is insufficient strengthening and anti-inflammatory effect of the drug, the main emphasis is on deodorizing quality, while there is no effective effect on periodontal tissue. This composition does not eliminate inflammation in the periodontal pockets and does not have sufficient penetration in the periodontal tissue and the mucous membrane of the oral cavity.

Known tools: dental elixir "Forest", containing chlorophyll-carotene mixture, which has a deodorizing and cleaning effect, dental elixir "Eucalyptus", containing biologically active substances of plant origin (St. John's wort, pine buds, eucalyptus), which has tanning, astringent, and antimicrobial properties that are detrimental to fungi of the genus Candida, the lemon elixir “Lemon”, which contains 40% formalin and borax as active components, is detrimental to fungal flora and streptococci, giving pronounced cleaning performance [3].

The disadvantage of these oral hygiene products is that they have insufficient strengthening and anti-inflammatory effects on periodontal tissues, and also do not eliminate the symptoms of inflammation in periodontal pockets, especially during severe purulent inflammation with gingivitis and periodontitis.

The closest in technical essence and the achieved positive effect and adopted by us for the prototype is the tooth elixir "Enzyme-1", which is a water-alcohol solution of antimicrobial enzymes (lysozyme and ribonuclease) [2]. As a stabilizer of these enzymes, 6% citric acid is used in this medium. The elixir has antimicrobial and antiviral properties, increases the natural immunity of the oral cavity, helps to normalize metabolic processes in the oral mucosa, and accelerates regeneration and epithelization. It has good taste, enhances salivation, prevents the formation of plaque, deodorizes and refreshes the oral cavity. The elixir is effective in diseases of the viral (herpetic and post-influenza stomatitis) and allergic etiology (multiforme exudative erythema, medicinal stomatitis, etc.), as well as traumatic injuries of the oral mucosa and diseases of the large salivary glands, accompanied by a decrease in their function.

Enzyme-1 is used for oral hygiene in the form of rinses with an aqueous solution at the rate of 20 drops per 0.5 cup of water, with lesions of the oral mucosa of a viral or allergic nature - in the form of baths at the rate of 40 drops per 0.25 cup of water 4-5 times a day. The duration of the procedure is 2-3 minutes.

The disadvantage of this drug is that citric acid is used as a stabilizing agent, which is significantly inferior to alcohols in effectiveness. When using this acid-containing product, dental dentin hypersensitivity may occur, especially in patients with gum recession and periodontopathy.

The task is to create a therapeutic and prophylactic agent for daily oral care that has anti-inflammatory, desensitizing, anti-carious and cleansing effects using available components and a fairly simple technology.

The problem is achieved by using a biologically active additive of plant origin with included chloroform extracts of nettle and plantain herbs, chamomile and calendula flowers, myrrh, preservative, glycerin, dye, perfume and alcohol, while the biologically active additive additionally contains vitamin A , sodium fluoride, anionic surfactant, antiseptic, as a preservative - nipagin, nipazole, perfume, dye with the following components, wt.%:

chloroform plant extract 25.0-30.0 vitamin A 0.001-0.002 sodium fluoride 0.2-0.3 anionic surfactant 0.5-2.0 antiseptic 0.01-1.0 glycerol 2.5-3.0 nipagin 0.2-0.3 nipazole 0.08-0.1 perfume 0.1-0.2 dye 0.001-0.002 alcohol up to 100%

To prepare the chloroform extract of herbs, dried and chopped nettle and plantain herbs, myrrh, chamomile and calendula flowers are mixed in equal amounts and kept under a bactericidal lamp for 3 hours. Then the mixture is poured with chloroform in a ratio of 1:20, stirred and insisted in a dark place for 2-3 days. Herbs depleted in chloroform extraction are poured with a 40% solution of ethyl alcohol to extract biologically active components that pass into the water-alcohol fraction.

The plant mixture is prepared by evaporation in reverse phase. For this, a chloroform extract of medicinal plant material is loaded into the reactor. The process is carried out under vacuum at a temperature of 40 ± 1 ° C for 2.5 hours until complete removal of chloroform. Chloroform vapors are cooled in a reflux condenser, condensed, and fed to the extraction of medicinal plant materials.

As a result of studies to select the optimal concentrations of all components of the elixir for the treatment of oral diseases, we found that a decrease in the concentration of phytocomponents of less than 10 wt.% Reduces the biological activity of the finished product, an increase in the concentration of phytocomponents above 15 wt.% Is not advisable, since the biological activity does not increase, while the consumption of raw materials increases, that is, it is not economically profitable. A decrease in the concentration of nipagin below 0.2 wt.% Reduces the bactericidal properties of the finished product, and an increase in the concentration above 0.3 wt.% Causes irritation of the oral mucosa. A decrease in the concentration of nipazole below 0.08 wt.% Reduces the bactericidal properties of the finished product, and an increase concentrations above 0.1 wt.% cause mucosal irritation. A decrease in the concentration of perfumes of less than 0.1 wt.% Does not give the necessary pleasant aroma to the finished product, and an increase in the concentration above 0.2 wt.% Causes mucosal irritation and allergic reactions. A decrease in the concentration of the dye (brilliant green) below 0.001 wt.% Does not give the finished product the necessary color, and an increase in the concentration of the dye above 0.002 wt.% Causes irritation of the mucous membrane and allergic reactions. As for temperature, lowering it below 20 ° C slows down the reaction rate and increases the preparation time of the finished product, while increasing the temperature above 30 ° C is not permissible. When reducing the mixing time of the solution to less than 20 minutes, mass uniformity is not achieved, the increase in mixing time is associated with the consumption of electricity, which is not advisable from the point of view of economy.

The extract of herbs used includes the full range of biologically active components necessary for both periodontal tissues and the mucous membrane. It includes carotenoids, tocopherols and flavonoids, which are found in the grass of nettles and plantains, myrrh, chamomile and calendula flowers, which have antioxidant properties, inhibiting the formation of excess amounts of peroxide compounds that destructively affect the membranes of the cells of the oral mucosa. In addition, these compounds have anti-inflammatory, capillary-strengthening, desensitizing effects. Regulate fat, mineral, water metabolism, periodontal tissue regeneration processes, have bactericidal and fungicidal properties, and have estrogenic activity. Together with ascorbic acid, flavonoids participate in redox processes, which helps to improve blood circulation of the mucosa and periodontium.

Examples of specific performance of obtaining therapeutic prophylactic elixir for oral care.

Example 1. A plant suspension is prepared by evaporation in reverse phase. For this, a chloroform extract of medicinal plant material is loaded into the reactor. The process is carried out under vacuum at a temperature of 40 ± 1 ° C, for 2.5 hours until complete removal of chloroform. Chloroform vapors are cooled in a reflux condenser, condensed, and fed to the extraction of medicinal plant materials.

Refined alcohol of 71.79 wt.% Is added into the mixer and, with the stirrer turned on, nipazole 0.06 wt.% And nipagin 0.1 wt.% Are added. The mixture is stirred at a temperature of 10-20 ° C for 10-20 minutes, then glycerol 0.5 wt.% Is added, then chloroform plant extract is slowly poured into 20.0 wt.%, Vitamin A is 0.0005 wt.%, sodium fluoride 0.2 wt.%, anionic surfactant (lauryl sulfate) 0.5 wt.%, dye 0.0005 wt.% (brilliant green) and fragrance (lime color) 0.005 wt.%. The finished elixir is Packed in polymer or glass bottles.

Result: the obtained elixir does not possess the necessary bioavailability, does not stimulate blood circulation in the periodontal tissues to the right extent, does not provide the proper keratoplastic effect, does not have bactericidal properties, does not reduce the increased sensitivity of dental dentin, it does not have a pleasant smell.

Example 2. Carried out analogously to example 1, but refined alcohol is poured into the mixer 71.79 wt.% And with the stirrer switched on, nipazole 0.08 wt.% And nipagin 0.2 wt.% Are added. The mixture is stirred at 20-30 ° C for 20-30 minutes, then glycerol 3.0 wt.% Is added, then chloroform plant extract is slowly poured into 25.0 wt.%, Anionic surfactant (lauryl sulfate) 2.0 wt.% , antiseptic agent 0.01-1.0 wt.%, sodium fluoride 0.3 wt.%, vitamin "A" 0.001 wt.%, dye 0.001 wt.% (brilliant green) and fragrance (lime color) 0.1 wt. .%. The finished elixir is Packed in polymer or glass bottles.

Result: the obtained elixir has the necessary biological activity, stimulates blood circulation in the periodontium to the right extent, and has the necessary keratoplastic and desensitizing effect. The dental elixir has a pleasant smell, color, delicate and uniform consistency.

Example 3. Carried out analogously to example 1, but refined alcohol is poured into the mixer 52.15 wt.% And with the stirrer switched on, nipazole 0.15 wt.% And nipagin 0.4 wt.% Are added. The mixture is stirred at a temperature of 30-40 ° C for 30-40 minutes, then glycerol 5.0 wt.% Is added, then chloroform plant extract is slowly poured into 35.0 wt.%, Antiseptic 0.1-2.0 wt.% , sodium fluoride 0.3-0.4 wt.%, vitamin "A" 0.005 wt.%, anionic surfactant (lauryl sulfate) 3.0 wt.%, dye 0.003 wt.% (brilliant green) and fragrance (lime color) 0.3 wt.%. The finished elixir is Packed in polymer or glass bottles.

Result: the obtained elixir does not have greater biological activity and greater cleansing ability. While the consumption of raw materials increases, which is economically disadvantageous. The elixir strongly irritates the mucous membrane and causes allergic reactions in people with hypersensitivity to dental dentin, has a pungent odor.

Example 4. Carried out analogously to example 1, but refined alcohol of 59.40 wt.% Is poured into the mixer and with the stirrer switched on, nipazole 0.1 wt.% And nipagin 0.3 wt.% Are added. The mixture is stirred at a temperature of 20-30 ° C for 20-30 minutes, then glycerol 2.5 wt.% Is added, then chloroform extract of plants 30.0 wt.%, Anionic surfactant (lauryl sulfate) 0.5-2 are slowly poured. 0 wt.%, Antiseptic 0.01-1.0 wt.%, Sodium fluoride 0.3 wt.%, Vitamin A 0.002 wt.%, Dye 0.002 wt.% (Brilliant green) and fragrance (lime color) 0, 2 wt.%. The finished elixir is Packed in polymer or glass bottles.

Result: the obtained therapeutic and prophylactic elixir has a prolonged biological activity, greater anti-inflammatory ability and a pronounced desensitizing property, which allows it to be used in patients with increased sensitivity of dentin and tooth enamel, with gingivitis, periodontitis, in order to prevent dental caries.

Due to the depth of penetration of the complex of biologically active substances into periodontal pockets, as well as the prolonged action, the effect is achieved with a lower consumption of medical and hygiene products. In addition, sodium fluoride, introduced into the elixir, reduces the aggressive properties of plaque, reduces the precipitation and coefficient of activity of calcium and phosphorus ions. The inclusion of an anionic surfactant - lauryl sulfate provides hydrophobization of tooth enamel, which reduces the intensity of plaque formation, inhibits the activity of intracellular bacterial enzymes.

Tests at the Center for Dentistry of the Russian Academy of Sciences and at the Stavropol State Medical Academy on animals and humans have shown that the proposed treatment and prophylactic elixir for oral care is non-toxic, does not have irritating and allergenic effects, has a positive effect on the nutrition of periodontal tissues, as well as an inhibitory effect on enzyme metabolism in the oral cavity.

The simplicity of the process, the availability and low price of plant materials makes it possible to create mass production of effective domestic therapeutic and preventive elixirs

The invention in comparison with the prototype and other known technical solutions has the following advantages:

- the provision of therapeutic action for gingivitis and periodontitis;

- providing a therapeutic effect on teeth with increased sensitivity of enamel and dentin;

- low consumption of funds;

- the exclusion of irritating and allergenic effects;

- maintaining favorable organoleptic properties of the drug;

- ecological purity of the drug.

INFORMATION SOURCES

1. Akulovich A.V. Oral hygiene product for the prevention and treatment of periodontal diseases manufactured by GlaxoSmithKline // Dentistry today. No. 7 (29). - 2003. - P.65

2. Yakovleva V.I., Trofimova E.K., Davidovich T.P., Prosviryak G.P. Diagnosis, treatment and prevention of dental diseases // Minsk, Izd. Higher School, p. 471. - 1994.

3. Therapeutic dentistry. Edited by prof. E.B. Borovsky // Moscow. Ed. MIA. S.355. - 1998.

Claims (2)

1. Therapeutic and prophylactic elixir for caring for the oral cavity, containing an extract of medicinal plants, dye, alcohol, characterized in that the extract of medicinal plants contains chloroform extract of nettle and plantain herbs, chamomile and calendula flowers, myrrh, and vitamin A ", Sodium fluoride, anionic surfactant, antiseptic, glycerin, nipagin, nipazole, perfume with the following components, wt.%: chloroform plant extract 25.0-30.0 vitamin A 0.001-0.002 sodium fluoride 0.2-0.3 anionic surfactant 0.5-2.0 antiseptic 0.01-1.0 glycerol 2.5-3.0 nipagin 0.2-0.3 nipazole 0.08-0.1 perfume 0.1-0.2 dye 0.001-0.002 alcohol up to 100% 2. The treatment and prophylactic elixir according to claim 1, characterized in that decamethoxin is used as an antiseptic and lauryl sulfate is used as an anionic surfactant.