RU2017112747A - Фармацевтические композиции, содержащие декстрометорфановое соединение и хинидин для лечения возбуждения при деменции - Google Patents
Фармацевтические композиции, содержащие декстрометорфановое соединение и хинидин для лечения возбуждения при деменции Download PDFInfo
- Publication number
- RU2017112747A RU2017112747A RU2017112747A RU2017112747A RU2017112747A RU 2017112747 A RU2017112747 A RU 2017112747A RU 2017112747 A RU2017112747 A RU 2017112747A RU 2017112747 A RU2017112747 A RU 2017112747A RU 2017112747 A RU2017112747 A RU 2017112747A
- Authority
- RU
- Russia
- Prior art keywords
- quinidine
- treatment
- dementia
- dextrometorphanic
- demenium
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (8)
1. Способ лечения возбуждения и/или агрессии и/или связанных с ними симптомов у пациента с деменцией, включающий введение нуждающемуся в этом пациенту дейтерированного декстрометорфана и хинидина.
2. Способ по п.1, в котором типом деменции является болезнь Альцгеймера.
3. Дейтерированный декстрометорфан и хинидин для применения в лечении возбуждения и/или агрессии и/или связанных с ними симптомов у пациента с деменцией.
4. Дейтерированный декстрометорфан и хинидин по п.3, где типом деменции является болезнь Альцгеймера.
5. Применение дейтерированного декстрометорфана и хинидина для лечения возбуждения и/или агрессии и/или связанных с ними симптомов у пациента с деменцией.
6. Применение по п.5, где типом деменции является болезнь Альцгеймера.
7. Применение дейтерированного декстрометорфана и хинидина для получения лекарственного средства для лечения возбуждения и/или агрессии и/или связанных с ними симптомов у пациента с деменцией.
8. Применение по п.7, где типом деменции является болезнь Альцгеймера.
Applications Claiming Priority (35)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462050170P | 2014-09-14 | 2014-09-14 | |
| US62/050,170 | 2014-09-14 | ||
| US201462061451P | 2014-10-08 | 2014-10-08 | |
| US62/061,451 | 2014-10-08 | ||
| US201462063122P | 2014-10-13 | 2014-10-13 | |
| US62/063,122 | 2014-10-13 | ||
| US201462063861P | 2014-10-14 | 2014-10-14 | |
| US62/063,861 | 2014-10-14 | ||
| US201462068742P | 2014-10-26 | 2014-10-26 | |
| US62/068,742 | 2014-10-26 | ||
| US201562111053P | 2015-02-02 | 2015-02-02 | |
| US62/111,053 | 2015-02-02 | ||
| US201562111590P | 2015-02-03 | 2015-02-03 | |
| US62/111,590 | 2015-02-03 | ||
| US201562128446P | 2015-03-04 | 2015-03-04 | |
| US62/128,446 | 2015-03-04 | ||
| US201562162140P | 2015-05-15 | 2015-05-15 | |
| US62/162,140 | 2015-05-15 | ||
| US201562165535P | 2015-05-22 | 2015-05-22 | |
| US62/165,535 | 2015-05-22 | ||
| US201562169997P | 2015-06-02 | 2015-06-02 | |
| US62/169,997 | 2015-06-02 | ||
| US201562180026P | 2015-06-15 | 2015-06-15 | |
| US62/180,026 | 2015-06-15 | ||
| US201562193347P | 2015-07-16 | 2015-07-16 | |
| US62/193,347 | 2015-07-16 | ||
| US201562205061P | 2015-08-14 | 2015-08-14 | |
| US62/205,061 | 2015-08-14 | ||
| US201562216636P | 2015-09-10 | 2015-09-10 | |
| US62/216,636 | 2015-09-10 | ||
| US201562217142P | 2015-09-11 | 2015-09-11 | |
| US201562217470P | 2015-09-11 | 2015-09-11 | |
| US62/217,470 | 2015-09-11 | ||
| US62/217,142 | 2015-09-11 | ||
| PCT/US2015/049934 WO2016040930A1 (en) | 2014-09-14 | 2015-09-14 | Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020116666A Division RU2020116666A (ru) | 2014-09-14 | 2015-09-14 | Фармацевтические композиции, содержащие декстрометорфановое соединение и хинидин для лечения возбуждения при деменции |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2017112747A true RU2017112747A (ru) | 2018-10-15 |
| RU2017112747A3 RU2017112747A3 (ru) | 2019-04-29 |
Family
ID=55459653
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020116666A RU2020116666A (ru) | 2014-09-14 | 2015-09-14 | Фармацевтические композиции, содержащие декстрометорфановое соединение и хинидин для лечения возбуждения при деменции |
| RU2017112747A RU2017112747A (ru) | 2014-09-14 | 2015-09-14 | Фармацевтические композиции, содержащие декстрометорфановое соединение и хинидин для лечения возбуждения при деменции |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020116666A RU2020116666A (ru) | 2014-09-14 | 2015-09-14 | Фармацевтические композиции, содержащие декстрометорфановое соединение и хинидин для лечения возбуждения при деменции |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20190111047A1 (ru) |
| EP (4) | EP4166141A1 (ru) |
| JP (4) | JP2017531033A (ru) |
| KR (1) | KR20170052684A (ru) |
| CN (3) | CN110664801A (ru) |
| AU (3) | AU2015314710A1 (ru) |
| CA (1) | CA2960031A1 (ru) |
| IL (2) | IL250786A0 (ru) |
| MX (3) | MX2017003066A (ru) |
| PH (1) | PH12017500444A1 (ru) |
| RU (2) | RU2020116666A (ru) |
| SG (2) | SG11201701645WA (ru) |
| TW (3) | TW202106301A (ru) |
| WO (1) | WO2016040930A1 (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2994169A1 (en) * | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for use in treating agitation |
| WO2017020014A1 (en) * | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for use in treating agitation |
| US10730841B2 (en) * | 2016-07-04 | 2020-08-04 | Avanir Pharmaceuticals, Inc. | Methods for the synthesis of deuterated dextromethorphan |
| US11478467B2 (en) | 2017-05-04 | 2022-10-25 | Sreenivasarao Vepachedu | Targeted drug rescue with novel compositions, combinations, and methods thereof |
| CN112424600B (zh) * | 2018-05-18 | 2023-10-10 | 阿纳韦克斯生命科学公司 | σ-1激动剂治疗的优化和受治疗者的筛选方法 |
| CN112437659B (zh) * | 2019-01-07 | 2022-04-12 | 安泰赛普生物风投二代有限责任公司 | 用于治疗抑郁症的右美沙芬和安非他酮的组合 |
| EA202193178A1 (ru) * | 2019-03-18 | 2022-02-21 | Аванир Фармасьютикалз, Инк. | Способы лечения негативных симптомов шизофрении с помощью дейтерированного декстрометорфана и хинидина |
| AU2021263354A1 (en) * | 2020-04-27 | 2022-10-27 | Avanir Pharmaceuticals Inc. | Methods of treating agitation associated with Alzheimer's disease |
| CN115245515A (zh) * | 2021-04-27 | 2022-10-28 | 杭州剂泰医药科技有限责任公司 | 一种组合物的医药用途 |
| CN115322150B (zh) * | 2021-05-11 | 2024-05-28 | 深圳信立泰药业股份有限公司 | 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途 |
| CN113209042A (zh) * | 2021-05-28 | 2021-08-06 | 珠海润都制药股份有限公司 | 一种氢溴酸右美沙芬硫酸奎尼丁胶囊及其制备方法 |
| CA3236017A1 (en) * | 2021-10-27 | 2023-05-04 | Sanjay Dube | Methods of treating agitation associated with alzheimer's disease |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US5166207A (en) | 1991-06-17 | 1992-11-24 | Neurotherapeutics, Inc. | Method for enhancing the systemic delivery of dextromethorphan for the treatment of neurological disorders |
| US5366980A (en) | 1991-06-17 | 1994-11-22 | Smith Richard A | Use of dextromethorphan and an oxidase inhibitor to treat dermatitis |
| US5206248A (en) | 1992-03-27 | 1993-04-27 | Smith Richard A | Method for reducing emotional lability |
| US5350756A (en) | 1991-06-17 | 1994-09-27 | Smith Richard A | Use of a cytochrome oxidase inhibitor to increase the cough-suppressing activity of dextromorphan |
| TW264473B (ru) * | 1993-01-06 | 1995-12-01 | Hoffmann La Roche | |
| EP0788359B1 (en) | 1994-09-22 | 2006-07-12 | Richard Alan Smith | Combination of dextromethorphan with quinidine or quinine sulfate for treating a variety of intractable disorders |
| US5874443A (en) | 1995-10-19 | 1999-02-23 | Trega Biosciences, Inc. | Isoquinoline derivatives and isoquinoline combinatorial libraries |
| US5886210A (en) | 1996-08-22 | 1999-03-23 | Rohm And Haas Company | Method for preparing aromatic compounds |
| US5922683A (en) | 1997-05-29 | 1999-07-13 | Abbott Laboratories | Multicyclic erythromycin derivatives |
| ES2352739T3 (es) | 1997-11-21 | 2011-02-22 | Purdue Neuroscience Company | 2-aminoacetamidas sustituidas y el uso de las mismas. |
| RU2217421C2 (ru) | 1998-03-26 | 2003-11-27 | Шионоги & Ко., Лтд. | Производные индола, обладающие антивирусной активностью |
| US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| FR2784988B1 (fr) | 1998-10-23 | 2002-09-20 | Adir | Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| TWI326214B (en) * | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
| EP1986639A4 (en) * | 2006-02-03 | 2010-04-28 | Avanir Pharmaceuticals | PHARMACEUTICAL COMPOSITIONS OF DEXTROMETHORPHANE AND CHINIDINE FOR THE TREATMENT OF DEPRESSION, FEAR STATES AND NEURODEEGENERATIVE DISEASES |
| WO2007103474A2 (en) * | 2006-03-07 | 2007-09-13 | University Of Florida Research Foundation, Inc. | Drug adherence monitoring system |
| WO2008097924A2 (en) * | 2007-02-05 | 2008-08-14 | Avanir Pharmaceuticals | Pharmaceutical compositions comprising dextromethorphan analogs for the treatment of neurological disorders |
| DK2345653T3 (da) | 2007-05-01 | 2013-04-08 | Concert Pharmaceuticals Inc | Morphinanforbindelser |
| MX2011002994A (es) * | 2008-09-19 | 2011-05-30 | Concert Pharmaceuticals Inc | Compuestos de morfinan. |
| WO2010062692A1 (en) * | 2008-10-30 | 2010-06-03 | Concert Pharmaceuticals Inc. | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
| BRPI0915267A2 (pt) * | 2008-11-14 | 2015-08-18 | Concert Pharmaceuticals Inc | Composto, composição farmacêutica livre de pirogênio, e, método de tratamento de uma doença ou uma condição |
| CN106163522A (zh) * | 2013-11-05 | 2016-11-23 | 安泰赛普生物风投二代有限责任公司 | 包含安非他酮或相关化合物和右美沙芬的组合物和方法 |
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2015
- 2015-09-14 TW TW109114123A patent/TW202106301A/zh unknown
- 2015-09-14 CN CN201910903770.XA patent/CN110664801A/zh active Pending
- 2015-09-14 US US15/510,498 patent/US20190111047A1/en not_active Abandoned
- 2015-09-14 MX MX2017003066A patent/MX2017003066A/es unknown
- 2015-09-14 CN CN202311175974.9A patent/CN117427077A/zh active Pending
- 2015-09-14 SG SG11201701645WA patent/SG11201701645WA/en unknown
- 2015-09-14 CN CN201580049454.0A patent/CN107072990A/zh active Pending
- 2015-09-14 EP EP22195837.4A patent/EP4166141A1/en active Pending
- 2015-09-14 EP EP15840718.9A patent/EP3193872A4/en not_active Withdrawn
- 2015-09-14 TW TW110139834A patent/TW202231278A/zh unknown
- 2015-09-14 JP JP2017533726A patent/JP2017531033A/ja active Pending
- 2015-09-14 CA CA2960031A patent/CA2960031A1/en active Pending
- 2015-09-14 RU RU2020116666A patent/RU2020116666A/ru unknown
- 2015-09-14 AU AU2015314710A patent/AU2015314710A1/en not_active Abandoned
- 2015-09-14 EP EP20159783.8A patent/EP3708168A3/en not_active Withdrawn
- 2015-09-14 KR KR1020177009991A patent/KR20170052684A/ko not_active Application Discontinuation
- 2015-09-14 WO PCT/US2015/049934 patent/WO2016040930A1/en active Application Filing
- 2015-09-14 RU RU2017112747A patent/RU2017112747A/ru not_active Application Discontinuation
- 2015-09-14 SG SG10201901242PA patent/SG10201901242PA/en unknown
- 2015-09-14 EP EP21178170.3A patent/EP3932907A3/en not_active Withdrawn
- 2015-09-14 TW TW104130311A patent/TW201613591A/zh unknown
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2017
- 2017-02-26 IL IL250786A patent/IL250786A0/en unknown
- 2017-03-08 MX MX2021010696A patent/MX2021010696A/es unknown
- 2017-03-08 MX MX2022008181A patent/MX2022008181A/es unknown
- 2017-03-09 PH PH12017500444A patent/PH12017500444A1/en unknown
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2019
- 2019-10-08 US US16/596,236 patent/US20200289499A1/en not_active Abandoned
- 2019-11-06 JP JP2019201410A patent/JP2020019818A/ja not_active Withdrawn
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2020
- 2020-05-18 IL IL274742A patent/IL274742A/en unknown
- 2020-12-15 AU AU2020289733A patent/AU2020289733A1/en not_active Abandoned
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2021
- 2021-03-08 JP JP2021036318A patent/JP7360409B2/ja active Active
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2022
- 2022-12-06 AU AU2022283671A patent/AU2022283671A1/en active Pending
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2023
- 2023-04-24 US US18/305,589 patent/US20240082237A1/en active Pending
- 2023-06-12 JP JP2023096152A patent/JP2023105265A/ja active Pending
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