RU2017112747A - PHARMACEUTICAL COMPOSITIONS CONTAINING A DEXTROMETORPHANIC COMPOUND AND QUINIDINE FOR THE TREATMENT OF EXCITATION IN DEMENIUM - Google Patents
PHARMACEUTICAL COMPOSITIONS CONTAINING A DEXTROMETORPHANIC COMPOUND AND QUINIDINE FOR THE TREATMENT OF EXCITATION IN DEMENIUM Download PDFInfo
- Publication number
- RU2017112747A RU2017112747A RU2017112747A RU2017112747A RU2017112747A RU 2017112747 A RU2017112747 A RU 2017112747A RU 2017112747 A RU2017112747 A RU 2017112747A RU 2017112747 A RU2017112747 A RU 2017112747A RU 2017112747 A RU2017112747 A RU 2017112747A
- Authority
- RU
- Russia
- Prior art keywords
- quinidine
- treatment
- dementia
- dextrometorphanic
- demenium
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (8)
Applications Claiming Priority (35)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462050170P | 2014-09-14 | 2014-09-14 | |
US62/050,170 | 2014-09-14 | ||
US201462061451P | 2014-10-08 | 2014-10-08 | |
US62/061,451 | 2014-10-08 | ||
US201462063122P | 2014-10-13 | 2014-10-13 | |
US62/063,122 | 2014-10-13 | ||
US201462063861P | 2014-10-14 | 2014-10-14 | |
US62/063,861 | 2014-10-14 | ||
US201462068742P | 2014-10-26 | 2014-10-26 | |
US62/068,742 | 2014-10-26 | ||
US201562111053P | 2015-02-02 | 2015-02-02 | |
US62/111,053 | 2015-02-02 | ||
US201562111590P | 2015-02-03 | 2015-02-03 | |
US62/111,590 | 2015-02-03 | ||
US201562128446P | 2015-03-04 | 2015-03-04 | |
US62/128,446 | 2015-03-04 | ||
US201562162140P | 2015-05-15 | 2015-05-15 | |
US62/162,140 | 2015-05-15 | ||
US201562165535P | 2015-05-22 | 2015-05-22 | |
US62/165,535 | 2015-05-22 | ||
US201562169997P | 2015-06-02 | 2015-06-02 | |
US62/169,997 | 2015-06-02 | ||
US201562180026P | 2015-06-15 | 2015-06-15 | |
US62/180,026 | 2015-06-15 | ||
US201562193347P | 2015-07-16 | 2015-07-16 | |
US62/193,347 | 2015-07-16 | ||
US201562205061P | 2015-08-14 | 2015-08-14 | |
US62/205,061 | 2015-08-14 | ||
US201562216636P | 2015-09-10 | 2015-09-10 | |
US62/216,636 | 2015-09-10 | ||
US201562217470P | 2015-09-11 | 2015-09-11 | |
US201562217142P | 2015-09-11 | 2015-09-11 | |
US62/217,142 | 2015-09-11 | ||
US62/217,470 | 2015-09-11 | ||
PCT/US2015/049934 WO2016040930A1 (en) | 2014-09-14 | 2015-09-14 | Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2020116666A Division RU2020116666A (en) | 2014-09-14 | 2015-09-14 | PHARMACEUTICAL COMPOSITIONS CONTAINING A DEXTROMETORPHANE COMPOUND AND QUINIDINE FOR THE TREATMENT OF EXCITATION IN DEMENSE |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2017112747A true RU2017112747A (en) | 2018-10-15 |
RU2017112747A3 RU2017112747A3 (en) | 2019-04-29 |
Family
ID=55459653
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2020116666A RU2020116666A (en) | 2014-09-14 | 2015-09-14 | PHARMACEUTICAL COMPOSITIONS CONTAINING A DEXTROMETORPHANE COMPOUND AND QUINIDINE FOR THE TREATMENT OF EXCITATION IN DEMENSE |
RU2017112747A RU2017112747A (en) | 2014-09-14 | 2015-09-14 | PHARMACEUTICAL COMPOSITIONS CONTAINING A DEXTROMETORPHANIC COMPOUND AND QUINIDINE FOR THE TREATMENT OF EXCITATION IN DEMENIUM |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2020116666A RU2020116666A (en) | 2014-09-14 | 2015-09-14 | PHARMACEUTICAL COMPOSITIONS CONTAINING A DEXTROMETORPHANE COMPOUND AND QUINIDINE FOR THE TREATMENT OF EXCITATION IN DEMENSE |
Country Status (14)
Country | Link |
---|---|
US (3) | US20190111047A1 (en) |
EP (4) | EP3193872A4 (en) |
JP (4) | JP2017531033A (en) |
KR (1) | KR20170052684A (en) |
CN (3) | CN117427077A (en) |
AU (3) | AU2015314710A1 (en) |
CA (1) | CA2960031A1 (en) |
IL (2) | IL250786A0 (en) |
MX (3) | MX2017003066A (en) |
PH (1) | PH12017500444A1 (en) |
RU (2) | RU2020116666A (en) |
SG (2) | SG11201701645WA (en) |
TW (3) | TW202106301A (en) |
WO (1) | WO2016040930A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017020002A1 (en) * | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for use in treating agitation |
WO2017020014A1 (en) * | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for use in treating agitation |
EP4122919A1 (en) * | 2016-07-04 | 2023-01-25 | Avanir Pharmaceuticals, Inc. | Methods for the synthesis of deuterated dextromethorphan |
US11478467B2 (en) | 2017-05-04 | 2022-10-25 | Sreenivasarao Vepachedu | Targeted drug rescue with novel compositions, combinations, and methods thereof |
CN112424600B (en) * | 2018-05-18 | 2023-10-10 | 阿纳韦克斯生命科学公司 | Optimization of sigma-1 agonist therapy and screening methods for subjects |
CR20210368A (en) * | 2019-01-07 | 2021-12-10 | Antecip Bioventures Ii Llc | Combination of dextromethorphan and bupropion for treating depression |
JP2022526101A (en) * | 2019-03-18 | 2022-05-23 | アヴェニール ファーマシューティカルズ, インコーポレイテッド | How to treat negative symptoms of schizophrenia with deuterated dextromethorphan and quinidine |
AU2021263354A1 (en) * | 2020-04-27 | 2022-10-27 | Avanir Pharmaceuticals Inc. | Methods of treating agitation associated with Alzheimer's disease |
CN115245515A (en) * | 2021-04-27 | 2022-10-28 | 杭州剂泰医药科技有限责任公司 | Medical application of composition |
CN113209042A (en) * | 2021-05-28 | 2021-08-06 | 珠海润都制药股份有限公司 | Dextromethorphan hydrobromide quinidine sulfate capsule and preparation method thereof |
US20230131493A1 (en) * | 2021-10-27 | 2023-04-27 | Avanir Phrmaceuticals Inc. | Methods of treating agitation associated with alzheimer's disease |
Family Cites Families (27)
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US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
US5166207A (en) | 1991-06-17 | 1992-11-24 | Neurotherapeutics, Inc. | Method for enhancing the systemic delivery of dextromethorphan for the treatment of neurological disorders |
US5350756A (en) | 1991-06-17 | 1994-09-27 | Smith Richard A | Use of a cytochrome oxidase inhibitor to increase the cough-suppressing activity of dextromorphan |
US5206248A (en) | 1992-03-27 | 1993-04-27 | Smith Richard A | Method for reducing emotional lability |
US5366980A (en) | 1991-06-17 | 1994-11-22 | Smith Richard A | Use of dextromethorphan and an oxidase inhibitor to treat dermatitis |
TW264473B (en) * | 1993-01-06 | 1995-12-01 | Hoffmann La Roche | |
ES2268686T3 (en) | 1994-09-22 | 2007-03-16 | Richard Alan Smith | COMBINATION OF DEXTROMETORPHAN WITH QUINIDINE OR QUININE SULFATE TO TREAT DIFFERENT CURE DISORDERS. |
US5874443A (en) | 1995-10-19 | 1999-02-23 | Trega Biosciences, Inc. | Isoquinoline derivatives and isoquinoline combinatorial libraries |
US5886210A (en) | 1996-08-22 | 1999-03-23 | Rohm And Haas Company | Method for preparing aromatic compounds |
US5922683A (en) | 1997-05-29 | 1999-07-13 | Abbott Laboratories | Multicyclic erythromycin derivatives |
JP4070955B2 (en) | 1997-11-21 | 2008-04-02 | ユーロ−セルティーク エス.エイ. | Substituted 2-aminoacetamide and uses thereof |
ID26031A (en) | 1998-03-26 | 2000-11-16 | Shionogi & Co | INDOL DAMAGES THAT HAVE AN ANTIVIRAL ACTIVITY |
US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
FR2784988B1 (en) | 1998-10-23 | 2002-09-20 | Adir | NOVEL DIHYDRO AND TETRAHYDROQUINOLEINIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
TWI326214B (en) * | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
WO2007092329A2 (en) * | 2006-02-03 | 2007-08-16 | Avanir Pharmaceuticals | Pharmaceutical compositions for treating depression, anxiety and neurodegenerative disorders |
US20070224128A1 (en) * | 2006-03-07 | 2007-09-27 | Donn Michael Dennis | Drug adherence monitoring system |
WO2008097924A2 (en) * | 2007-02-05 | 2008-08-14 | Avanir Pharmaceuticals | Pharmaceutical compositions comprising dextromethorphan analogs for the treatment of neurological disorders |
EP2152709B1 (en) | 2007-05-01 | 2012-02-22 | Concert Pharmaceuticals Inc. | Morphinan compounds |
EA019343B1 (en) * | 2008-09-19 | 2014-02-28 | Консерт Фармасьютикалз Инк. | Deuterated morphinan compounds |
DK2397158T3 (en) * | 2008-10-30 | 2016-07-25 | Concert Pharmaceuticals Inc | COMBINATION OF MORPHINANFORBINDELSER AND antidepressants in treating pseudobulbar affect |
ES2444433T3 (en) * | 2008-11-14 | 2014-02-25 | Concert Pharmaceuticals, Inc. | Dioxopiperidinyl phthalimide derivatives substituted |
SG10201810888XA (en) * | 2013-11-05 | 2019-01-30 | Antecip Bioventures Ii Llc | Compositions and methods comprising bupropion or related compounds and dextromethorphan |
-
2015
- 2015-09-14 CN CN202311175974.9A patent/CN117427077A/en active Pending
- 2015-09-14 SG SG11201701645WA patent/SG11201701645WA/en unknown
- 2015-09-14 MX MX2017003066A patent/MX2017003066A/en unknown
- 2015-09-14 EP EP15840718.9A patent/EP3193872A4/en not_active Withdrawn
- 2015-09-14 TW TW109114123A patent/TW202106301A/en unknown
- 2015-09-14 RU RU2020116666A patent/RU2020116666A/en unknown
- 2015-09-14 TW TW104130311A patent/TW201613591A/en unknown
- 2015-09-14 KR KR1020177009991A patent/KR20170052684A/en not_active Application Discontinuation
- 2015-09-14 RU RU2017112747A patent/RU2017112747A/en not_active Application Discontinuation
- 2015-09-14 EP EP22195837.4A patent/EP4166141A1/en active Pending
- 2015-09-14 AU AU2015314710A patent/AU2015314710A1/en not_active Abandoned
- 2015-09-14 CA CA2960031A patent/CA2960031A1/en active Pending
- 2015-09-14 CN CN201910903770.XA patent/CN110664801A/en active Pending
- 2015-09-14 JP JP2017533726A patent/JP2017531033A/en active Pending
- 2015-09-14 US US15/510,498 patent/US20190111047A1/en not_active Abandoned
- 2015-09-14 EP EP21178170.3A patent/EP3932907A3/en not_active Withdrawn
- 2015-09-14 WO PCT/US2015/049934 patent/WO2016040930A1/en active Application Filing
- 2015-09-14 EP EP20159783.8A patent/EP3708168A3/en not_active Withdrawn
- 2015-09-14 SG SG10201901242PA patent/SG10201901242PA/en unknown
- 2015-09-14 CN CN201580049454.0A patent/CN107072990A/en active Pending
- 2015-09-14 TW TW110139834A patent/TW202231278A/en unknown
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2017
- 2017-02-26 IL IL250786A patent/IL250786A0/en unknown
- 2017-03-08 MX MX2021010696A patent/MX2021010696A/en unknown
- 2017-03-08 MX MX2022008181A patent/MX2022008181A/en unknown
- 2017-03-09 PH PH12017500444A patent/PH12017500444A1/en unknown
-
2019
- 2019-10-08 US US16/596,236 patent/US20200289499A1/en not_active Abandoned
- 2019-11-06 JP JP2019201410A patent/JP2020019818A/en not_active Withdrawn
-
2020
- 2020-05-18 IL IL274742A patent/IL274742A/en unknown
- 2020-12-15 AU AU2020289733A patent/AU2020289733A1/en not_active Abandoned
-
2021
- 2021-03-08 JP JP2021036318A patent/JP7360409B2/en active Active
-
2022
- 2022-12-06 AU AU2022283671A patent/AU2022283671A1/en active Pending
-
2023
- 2023-04-24 US US18/305,589 patent/US20240082237A1/en active Pending
- 2023-06-12 JP JP2023096152A patent/JP2023105265A/en active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20200730 |