PL3691620T3 - Inhibitory kinazy p38 zmniejszają poziom ekspresji genu dux4 i dalszych genów do leczenia fshd - Google Patents

Inhibitory kinazy p38 zmniejszają poziom ekspresji genu dux4 i dalszych genów do leczenia fshd

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Publication number
PL3691620T3
PL3691620T3 PL18792812.2T PL18792812T PL3691620T3 PL 3691620 T3 PL3691620 T3 PL 3691620T3 PL 18792812 T PL18792812 T PL 18792812T PL 3691620 T3 PL3691620 T3 PL 3691620T3
Authority
PL
Poland
Prior art keywords
fshd
treatment
gene expression
kinase inhibitors
downstream gene
Prior art date
Application number
PL18792812.2T
Other languages
English (en)
Inventor
Angela Marie CACACE
Luis Gustavo Alejandro ROJAS SOTO
Lorin A. Thompson Iii
Owen Brendan Wallace
Lucienne V. Ronco
Aaron Nakwon Chang
Ning SHEN
Alan Scott Robertson
Original Assignee
Fulcrum Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fulcrum Therapeutics, Inc. filed Critical Fulcrum Therapeutics, Inc.
Publication of PL3691620T3 publication Critical patent/PL3691620T3/pl

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061—Muscle cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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PL18792812.2T 2017-10-05 2018-10-05 Inhibitory kinazy p38 zmniejszają poziom ekspresji genu dux4 i dalszych genów do leczenia fshd PL3691620T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762568673P 2017-10-05 2017-10-05
US201762568754P 2017-10-05 2017-10-05
US201862682563P 2018-06-08 2018-06-08
US201862682565P 2018-06-08 2018-06-08
PCT/US2018/054642 WO2019071147A1 (en) 2017-10-05 2018-10-05 INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD

Publications (1)

Publication Number Publication Date
PL3691620T3 true PL3691620T3 (pl) 2022-11-21

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PL18792812.2T PL3691620T3 (pl) 2017-10-05 2018-10-05 Inhibitory kinazy p38 zmniejszają poziom ekspresji genu dux4 i dalszych genów do leczenia fshd

Country Status (28)

Country Link
US (5) US11479770B2 (pl)
EP (3) EP3691620B1 (pl)
JP (5) JP7012152B2 (pl)
KR (2) KR20200067170A (pl)
CN (4) CN114748622A (pl)
AU (2) AU2018346712B2 (pl)
BR (2) BR112020006677A2 (pl)
CA (4) CA3128468A1 (pl)
CL (3) CL2020000913A1 (pl)
CO (2) CO2020005351A2 (pl)
DK (1) DK3691620T3 (pl)
EC (1) ECSP20024210A (pl)
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