PE20070404A1 - Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona - Google Patents

Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona

Info

Publication number
PE20070404A1
PE20070404A1 PE2006000915A PE2006000915A PE20070404A1 PE 20070404 A1 PE20070404 A1 PE 20070404A1 PE 2006000915 A PE2006000915 A PE 2006000915A PE 2006000915 A PE2006000915 A PE 2006000915A PE 20070404 A1 PE20070404 A1 PE 20070404A1
Authority
PE
Peru
Prior art keywords
alkyl
sulfonamide
progesterone receptor
modulators
cyanopyrrol
Prior art date
Application number
PE2006000915A
Other languages
English (en)
Inventor
Casey Cameron Mccomas
Andrew Fensome
Edward George Melenski
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070404A1 publication Critical patent/PE20070404A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE R1 ES H, CN, SO2-ALQUILO(C1-C6), C(O)-ALQUILO(C1-C6), ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS; R3, R4, R5 Y R6 SON CADA UNO H, HALOGENO, CN, ALQUILO(C1-C6), ENTRE OTROS; R7 ES H, ALQUILO(C1-C6), ALQUENILO(C2-C6), ALQUINILO(C2-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[4-(5-CIANO-1-METIL-1H-PIRROL-2-IL)FENIL]PROPANO-1-SULFONAMIDA, N-[4-(5-CIANO-1-METIL-1H-PIRROL-2-IL)FENIL]-N-(METILSULFONIL)METANSULFONAMIDA, N-[4-(5-CIANO-1-METIL-1H-PIRROL-2-IL)FENIL]BUTAN-1-SULFONAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE PROGESTERONA SIENDO UTILES EN EL TRATAMIENTO DE DISMENORREA, SANGRADO UTERINO DISFUNCIONAL, TERAPIA DE REEMPLAZO HORMONAL
PE2006000915A 2005-07-29 2006-07-26 Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona PE20070404A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70400905P 2005-07-29 2005-07-29

Publications (1)

Publication Number Publication Date
PE20070404A1 true PE20070404A1 (es) 2007-05-10

Family

ID=37309001

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000915A PE20070404A1 (es) 2005-07-29 2006-07-26 Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona

Country Status (22)

Country Link
US (1) US7291643B2 (es)
EP (1) EP1910285A1 (es)
JP (1) JP5185114B2 (es)
KR (1) KR20080031915A (es)
CN (1) CN101233104A (es)
AR (1) AR056005A1 (es)
AU (1) AU2006275833B2 (es)
BR (1) BRPI0614412A2 (es)
CA (1) CA2612977A1 (es)
CR (1) CR9627A (es)
EC (1) ECSP088147A (es)
GT (1) GT200600336A (es)
HN (1) HN2008000135A (es)
IL (1) IL188314A (es)
MX (1) MX2008001338A (es)
NO (1) NO20076683L (es)
PE (1) PE20070404A1 (es)
RU (1) RU2007148077A (es)
SA (1) SA06270246B1 (es)
TW (1) TW200734302A (es)
UA (1) UA92500C2 (es)
WO (1) WO2007016212A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070182A1 (es) * 2005-07-29 2007-03-06 Wyeth Corp Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona
PE20070341A1 (es) * 2005-07-29 2007-04-13 Wyeth Corp Derivados de pirrol como moduladores del receptor de progesterona
TW200848019A (en) 2007-03-06 2008-12-16 Wyeth Corp Aryl sulfonamides useful for modulation of the progesterone receptor
TW200848021A (en) * 2007-03-06 2008-12-16 Wyeth Corp Sulfonylated heterocycles useful for modulation of the progesterone receptor
EA201070715A1 (ru) * 2007-12-20 2011-02-28 Тева Вимен'С Хелс, Инк. Режимы дозирования, фармацевтические композиции и упаковки для экстренной контрацепции
EP2914253B1 (en) 2012-11-05 2018-01-03 NantBioScience, Inc. Cyclic sulfonamide containing derivatives as inhibitors of hedgehog signaling pathway

Family Cites Families (21)

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US4680413A (en) * 1986-01-17 1987-07-14 Nippon Soda Co., Ltd. Process for the production of 3-phenyl-4-cyanopyrroles
US5455263A (en) * 1987-07-29 1995-10-03 American Cyanamid Company Methods for the control and the protection of warm-blooded animals against infestation and infection by helminths, acarids and arthropod endo- and ectoparasites
EP0339342A1 (de) * 1988-04-23 1989-11-02 Bayer Ag N-Substituierte N-Amino-pyrrole
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
DE4036645A1 (de) 1990-11-16 1992-05-21 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, deren enthaltende mittel und deren verwendung
JP2699024B2 (ja) 1990-11-22 1998-01-19 富士写真フイルム株式会社 新規な色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料
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US5187168A (en) * 1991-10-24 1993-02-16 American Home Products Corporation Substituted quinazolines as angiotensin II antagonists
WO1994017059A1 (en) 1993-01-29 1994-08-04 Nippon Soda Co., Ltd. Heterocyclic derivative
RU2166941C2 (ru) * 1995-06-07 2001-05-20 Ниппон Синяку Ко., Лтд. Производные пиррола и фармацевтическая композиция на их основе
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DE60210755T2 (de) * 2001-03-09 2006-11-16 Pfizer Products Inc., Groton Triazolopyridine als entzündungshemmende mittel
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ES2247271T3 (es) * 2001-04-04 2006-03-01 Pfizer Products Inc. Nuevos benzotriazoles como compuestos antiinflamatorios.
BR0316191A (pt) 2002-11-11 2005-09-27 Bayer Healthcare Ag Derivados de amino alcano de fenila ou heteroarila como antagonistas de receptor de ip
WO2004073594A2 (fr) 2003-02-12 2004-09-02 L'oreal Utilisation d’un inhibiteur de 15-hydroxy prostaglandine deshydrogenase pour favoriser la pigmentation de la peau ou des phaneres
BRPI0510278A (pt) * 2004-04-27 2007-10-30 Wyeth Corp método para produzir compostos, produto, e, composto
GT200500183A (es) 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
GT200500185A (es) 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos

Also Published As

Publication number Publication date
AR056005A1 (es) 2007-09-12
JP2009502947A (ja) 2009-01-29
CN101233104A (zh) 2008-07-30
GT200600336A (es) 2007-05-28
AU2006275833B2 (en) 2012-04-26
IL188314A0 (en) 2008-04-13
EP1910285A1 (en) 2008-04-16
ECSP088147A (es) 2008-02-20
MX2008001338A (es) 2008-03-25
AU2006275833A1 (en) 2007-02-08
JP5185114B2 (ja) 2013-04-17
TW200734302A (en) 2007-09-16
CA2612977A1 (en) 2007-02-08
BRPI0614412A2 (pt) 2016-11-22
US7291643B2 (en) 2007-11-06
CR9627A (es) 2008-03-06
HN2008000135A (es) 2010-08-19
WO2007016212A1 (en) 2007-02-08
NO20076683L (no) 2008-02-04
UA92500C2 (ru) 2010-11-10
SA06270246B1 (ar) 2010-11-22
KR20080031915A (ko) 2008-04-11
US20070027126A1 (en) 2007-02-01
IL188314A (en) 2012-09-24
RU2007148077A (ru) 2009-09-10

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