MX350258B - Emulsiones cationicas de aceite en agua. - Google Patents

Emulsiones cationicas de aceite en agua.

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Publication number
MX350258B
MX350258B MX2014000040A MX2014000040A MX350258B MX 350258 B MX350258 B MX 350258B MX 2014000040 A MX2014000040 A MX 2014000040A MX 2014000040 A MX2014000040 A MX 2014000040A MX 350258 B MX350258 B MX 350258B
Authority
MX
Mexico
Prior art keywords
cationic
water emulsions
cationic oil
nucleic acid
negatively charged
Prior art date
Application number
MX2014000040A
Other languages
English (en)
Other versions
MX2014000040A (es
Inventor
Brito Luis
Chan Michelle
Geall Andrew
O'hagan Derek
Singh Manmohan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2014000040A publication Critical patent/MX2014000040A/es
Publication of MX350258B publication Critical patent/MX350258B/es

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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Abstract

La presente invención se refiere a una emulsión de aceite en agua estable caracterizada porque comprende partículas que se dispersan en una fase continua acuosa, en donde el diámetro promedio de las partículas es de aproximadamente 80 nm a 150 nm , en donde el diámetro promedio no cambia por más d e10% cuando la emulsión es almacenada a 4°C durante un mes; y en donde la emulsión comprende un aceite y un lípido catiónico, en donde el grupo principal del lípido catiónico comprende una amina cuaternaria, y en donde: (i) la relación de aceite : lípido (mol: mol) es al menos aproximadamente 8: 1 (mol: mol); (ii) la concentración de lípido catiónico en la emulsión es de al menos aproximadamente 2.5 mM; y (iii) el lípido catiónico no es DC-colesterol.
MX2014000040A 2011-07-06 2012-07-06 Emulsiones cationicas de aceite en agua. MX350258B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161505109P 2011-07-06 2011-07-06
US201161545936P 2011-10-11 2011-10-11
US201261585641P 2012-01-11 2012-01-11
PCT/US2012/045845 WO2013006837A1 (en) 2011-07-06 2012-07-06 Cationic oil-in-water emulsions

Publications (2)

Publication Number Publication Date
MX2014000040A MX2014000040A (es) 2014-02-27
MX350258B true MX350258B (es) 2017-08-31

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MX2014000040A MX350258B (es) 2011-07-06 2012-07-06 Emulsiones cationicas de aceite en agua.

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US (3) US9636410B2 (es)
EP (2) EP3456316A1 (es)
JP (2) JP6120839B2 (es)
CN (1) CN103796639B (es)
AU (2) AU2012280904B2 (es)
BR (1) BR112014000235A8 (es)
CA (1) CA2840965C (es)
ES (1) ES2702318T3 (es)
MX (1) MX350258B (es)
RU (1) RU2649133C2 (es)
SG (1) SG10201605500TA (es)
WO (1) WO2013006837A1 (es)

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US10487332B2 (en) 2010-07-06 2019-11-26 Glaxosmithkline Biologicals Sa Immunisation of large mammals with low doses of RNA
PL3243526T3 (pl) 2010-07-06 2020-05-18 Glaxosmithkline Biologicals S.A. Dostarczanie rna w celu wyzwolenia wielu szlaków immunologicznych
MX2013000164A (es) 2010-07-06 2013-03-05 Novartis Ag Liposomas con lipidos que tienen valor de pka ventajoso para suministro de arn.
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JP6136343B2 (ja) 2012-06-12 2017-05-31 株式会社リコー 情報処理システム、情報処理方法、プログラム、及び記録媒体
CA3104876A1 (en) 2018-06-29 2020-01-02 Integria Healthcare (Australia) Pty Limited Immunomodulatory compositions and uses thereof

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AU2012280904B2 (en) 2017-02-23
AU2017203342A1 (en) 2017-06-08
CN103796639B (zh) 2017-05-31
RU2014104094A (ru) 2015-08-20
EP2729124A1 (en) 2014-05-14
EP2729124B1 (en) 2018-10-24
WO2013006837A1 (en) 2013-01-10
JP2016210792A (ja) 2016-12-15
US11167028B2 (en) 2021-11-09
US20140220083A1 (en) 2014-08-07
SG10201605500TA (en) 2016-08-30
CA2840965A1 (en) 2013-01-10
BR112014000235A8 (pt) 2018-03-06
EP3456316A1 (en) 2019-03-20
CN103796639A (zh) 2014-05-14
US9636410B2 (en) 2017-05-02
MX2014000040A (es) 2014-02-27
JP2014522841A (ja) 2014-09-08
US20170202960A1 (en) 2017-07-20
BR112014000235A2 (pt) 2017-02-14
US10183074B2 (en) 2019-01-22
AU2012280904A1 (en) 2013-05-09
RU2649133C2 (ru) 2018-03-29
CA2840965C (en) 2021-03-02
JP6120839B2 (ja) 2017-04-26

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