MX350198B - Emulsiones aceite en agua que contienen acidos nucleicos. - Google Patents

Emulsiones aceite en agua que contienen acidos nucleicos.

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Publication number
MX350198B
MX350198B MX2014000047A MX2014000047A MX350198B MX 350198 B MX350198 B MX 350198B MX 2014000047 A MX2014000047 A MX 2014000047A MX 2014000047 A MX2014000047 A MX 2014000047A MX 350198 B MX350198 B MX 350198B
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Mexico
Prior art keywords
oil
water emulsions
nucleic acids
contain nucleic
emulsion
Prior art date
Application number
MX2014000047A
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English (en)
Other versions
MX2014000047A (es
Inventor
Brito Luis
Chan Michelle
Geall Andrew
Ohagan Derek
Singh Manmohan
Original Assignee
Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2014000047A publication Critical patent/MX2014000047A/es
Publication of MX350198B publication Critical patent/MX350198B/es

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    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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Abstract

La presente invención se refiere a una emulsión aceite en gua catiónica inmunogénica caracterizada porque comprende partículas de emulsión que contienen un núcleo de aceite que está en fase líquida a 25°C y un lípido catiónico, y una molécula de ácido nucleico que forma un complejo con las partículas de emulsión, en donde el lípido catiónico en DOTAP, DOTMA, DOEPC, DSTAP, DODAC O DADAP, y la concentración del lípido catiónico en la emulsión aceite en agua es de 1.6 mg/ml a 25 mg/ml, en donde la molécula de ácido nucleico es un ARN autorreplicante que codifica par aun antígeno y en donde el diámetro promedio de las partículas de emulsión es de 80 nm a 180 nm y la relación N/P de la emulsión es de por lo menos 4: 1, en donde la relación N/P se refiere a la cantidad en moles de átomos de nitrógeno protonables en el lípido catiónico divididos entre la cantidad, en moles, de fosfatos en la molécula de ARN; con la condición de que la molécula de ácido nucleico no codifique para fosfatasa alcalina secretada, y con la condición adicional de que la molécula de ácido nucleico no sea un ARN codificado por el plásmido A317, cuya secuencia se muestra en la SEQ ID NO: 1.
MX2014000047A 2011-07-06 2012-07-06 Emulsiones aceite en agua que contienen acidos nucleicos. MX350198B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161505091P 2011-07-06 2011-07-06
US201261585639P 2012-01-11 2012-01-11
PCT/US2012/045840 WO2013006834A1 (en) 2011-07-06 2012-07-06 Oil-in-water emulsions that contain nucleic acids

Publications (2)

Publication Number Publication Date
MX2014000047A MX2014000047A (es) 2014-02-17
MX350198B true MX350198B (es) 2017-08-30

Family

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Family Applications (1)

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MX2014000047A MX350198B (es) 2011-07-06 2012-07-06 Emulsiones aceite en agua que contienen acidos nucleicos.

Country Status (13)

Country Link
US (3) US9655845B2 (es)
EP (2) EP3424495A1 (es)
JP (2) JP6059220B2 (es)
CN (1) CN103781470A (es)
AU (2) AU2012280901B2 (es)
BR (1) BR112014000227A8 (es)
CA (1) CA2840913C (es)
ES (1) ES2657547T3 (es)
MX (1) MX350198B (es)
RU (1) RU2606846C2 (es)
SG (1) SG10201605512WA (es)
TR (1) TR201802662T4 (es)
WO (1) WO2013006834A1 (es)

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