MX2022014505A - Activadores de la ampk. - Google Patents

Activadores de la ampk.

Info

Publication number
MX2022014505A
MX2022014505A MX2022014505A MX2022014505A MX2022014505A MX 2022014505 A MX2022014505 A MX 2022014505A MX 2022014505 A MX2022014505 A MX 2022014505A MX 2022014505 A MX2022014505 A MX 2022014505A MX 2022014505 A MX2022014505 A MX 2022014505A
Authority
MX
Mexico
Prior art keywords
ampk activators
ampk
gut
disorder
condition
Prior art date
Application number
MX2022014505A
Other languages
English (en)
Inventor
Shuwen He
Paul Richards
Iyassu Sebhat
Ann Weber
Nancy Thornberry
Lisa Krug
Brett Lauring
Original Assignee
Kallyope Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kallyope Inc filed Critical Kallyope Inc
Publication of MX2022014505A publication Critical patent/MX2022014505A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente divulgación se dirige, al menos en parte, a activadores de la AMPK útiles para el tratamiento de afecciones o trastornos asociados a la AMPK. En algunas realizaciones, la afección o el trastorno está asociado con el eje intestino-cerebro. En algunas realizaciones, la afección o el trastorno está asociado con la infección sistémica y la inflamación por tener una barrera intestinal permeable. En algunas realizaciones, los activadores de la AMPK son compuestos restringidos al intestino. En algunas realizaciones, los activadores de la AMPK son agonistas o agonistas parciales.
MX2022014505A 2020-05-19 2021-05-18 Activadores de la ampk. MX2022014505A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063027231P 2020-05-19 2020-05-19
US202063111837P 2020-11-10 2020-11-10
US202163141169P 2021-01-25 2021-01-25
PCT/US2021/032933 WO2021236617A1 (en) 2020-05-19 2021-05-18 Ampk activators

Publications (1)

Publication Number Publication Date
MX2022014505A true MX2022014505A (es) 2022-12-13

Family

ID=78707519

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022014505A MX2022014505A (es) 2020-05-19 2021-05-18 Activadores de la ampk.

Country Status (14)

Country Link
US (3) US11279702B2 (es)
EP (1) EP4153589A1 (es)
JP (1) JP2023526625A (es)
KR (1) KR20230012597A (es)
CN (1) CN116323608A (es)
AU (1) AU2021275038A1 (es)
BR (1) BR112022023359A2 (es)
CA (1) CA3178994A1 (es)
CL (1) CL2022003208A1 (es)
IL (1) IL298306A (es)
MX (1) MX2022014505A (es)
TW (1) TW202208360A (es)
UY (1) UY39222A (es)
WO (1) WO2021236617A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230012597A (ko) 2020-05-19 2023-01-26 칼리오페, 인크. Ampk 활성화제
AU2021297323A1 (en) 2020-06-26 2023-02-16 Kallyope, Inc. AMPK activators
WO2023097190A1 (en) * 2021-11-23 2023-06-01 Kallyope, Inc. Ampk activators
KR102638594B1 (ko) * 2022-05-30 2024-02-19 경희대학교 산학협력단 신규한 바이사이클로펜테인 화합물 및 그의 제조방법

Family Cites Families (344)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1087725C (zh) 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
AU2002224038B2 (en) * 2000-11-15 2006-03-09 Banyu Pharmaceutical Co., Ltd. Benzimidazole derivatives
JP4280070B2 (ja) 2001-02-16 2009-06-17 コンジュケム バイオテクノロジーズ インコーポレイテッド 胃腸疾患および胃腸障害の処置のための長期持続性グルカゴン様ペプチド２（ｇｌｐ−２）
EP1369698A1 (en) 2002-06-07 2003-12-10 Bayer Ag Diagnostics and therapeutics for diseases associated with somatostatin receptor 5 (SSTR5)
WO2005051890A1 (en) 2003-11-19 2005-06-09 Smithkline Beecham Corporation Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40
PL1704234T3 (pl) 2003-11-21 2012-06-29 Nps Pharma Inc Wytwarzanie glukagonopodobnego peptydu 2 i analogów
JP4859665B2 (ja) 2004-03-30 2012-01-25 武田薬品工業株式会社 アルコキシフェニルプロパン酸誘導体
JP2007284350A (ja) 2004-07-27 2007-11-01 Takeda Chem Ind Ltd 糖尿病治療剤
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
JP2008526734A (ja) 2004-12-31 2008-07-24 エスケー ケミカルズ カンパニー リミテッド 糖尿及び肥満治療予防に有効なキナゾリン誘導体
WO2006083612A1 (en) 2005-01-28 2006-08-10 Merck & Co., Inc. Antidiabetic bicyclic compounds
AU2006210954A1 (en) 2005-01-31 2006-08-10 Merck & Co., Inc. Antidiabetic bicyclic compounds
EP2295451A1 (en) 2005-05-04 2011-03-16 Zealand Pharma A/S Glucagon-like-peptide (GLP-2) analogues
CA2608819A1 (en) 2005-06-02 2006-12-07 F. Hoffmann-La Roche Ag Piperidin-4-yl-amide derivatives and their use as sst receptor subtype 5 antagonists
US20080221088A1 (en) 2005-06-23 2008-09-11 Vijay Kumar Potluri 3,4-Substituted Thiazoles as Ampk Activators
NZ564759A (en) 2005-06-30 2011-08-26 Prosidion Ltd GPCR agonists
EP1948785B1 (en) 2005-10-24 2014-01-15 Janssen Biotech, Inc. Glp-2 mimetibodies, polypeptides, compositions, methods and uses
US20090313709A1 (en) 2006-01-31 2009-12-17 Yoshihiko Kaisho Genetically Modified Animal and Use Thereof
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
DE602007010420D1 (de) 2006-04-11 2010-12-23 Arena Pharm Inc Verfahren zur verwendung des gpr119-rezeptors zur identifizierung von verbindungen zur erhöhung der knochenmasse bei einer person
TW200815377A (en) 2006-04-24 2008-04-01 Astellas Pharma Inc Oxadiazolidinedione compound
EP2021327B1 (en) 2006-05-15 2012-04-04 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
FR2903695B1 (fr) 2006-07-13 2008-10-24 Merck Sante Soc Par Actions Si Utilisation de derives d'imidazole activateurs de l'ampk, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR100826108B1 (ko) 2006-08-04 2008-04-29 한국화학연구원 퓨란-2-카복실산 유도체 및 그의 제조 방법
WO2008025798A1 (en) 2006-08-30 2008-03-06 Biovitrum Ab (Publ) Pyridine compounds for treating gpr119 related disorders
WO2008028117A2 (en) 2006-08-31 2008-03-06 Centocor, Inc. Glp-2 mimetibodies, polypeptides, compositions, methods and uses
WO2008063768A2 (en) 2006-10-12 2008-05-29 Case Western Reserve University Compositions and methods for treating metabolic diseases
WO2008054674A2 (en) 2006-10-31 2008-05-08 Merck & Co., Inc. Antidiabetic bicyclic compounds
WO2008054675A2 (en) 2006-10-31 2008-05-08 Merck & Co., Inc. Antidiabetic bicyclic compounds
EA023886B1 (ru) 2006-11-08 2016-07-29 Зеаланд Фарма А/С Селективные аналоги глюкагонподобного пептида-2 (glp-2)
US7750048B2 (en) 2006-11-15 2010-07-06 Janssen Pharmaceutica Nv GPR40 agonists
AU2007325315A1 (en) 2006-11-28 2008-06-05 Kalypsys Inc Heterocyclic modulators of TGR5
US20090035306A1 (en) 2006-11-29 2009-02-05 Kalypsys, Inc. Quinazolinone modulators of tgr5
US8101634B2 (en) 2006-12-06 2012-01-24 Glaxosmithkline Llc Bicyclic compounds and use as antidiabetics
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
CA2674237C (en) 2006-12-28 2015-11-24 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
CA2676417C (en) 2007-01-19 2016-06-28 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
US20080186971A1 (en) 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
US20080221161A1 (en) 2007-02-09 2008-09-11 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
ATE482209T1 (de) 2007-03-08 2010-10-15 Irm Llc Verbindungen und zusammensetzungen als modulatoren der gpr119-aktivität
JP2010526145A (ja) 2007-05-04 2010-07-29 ブリストル−マイヤーズ スクイブ カンパニー ［６，６］および［６，７］−二環式ｇｐｒ１１９ｇタンパク質結合受容体アゴニスト
ES2388315T3 (es) 2007-05-04 2012-10-11 Bristol-Myers Squibb Company Agonistas [6,5]-bicíclicos de receptores GPR119 acoplados a la proteína G
KR20080099174A (ko) 2007-05-07 2008-11-12 주식회사 머젠스 비만, 당뇨, 대사성 질환, 퇴행성 질환 및 미토콘드리아이상 질환의 치료 또는 예방을 위한 나프토퀴논계 약제조성물
AU2008276055B2 (en) 2007-07-17 2013-01-31 Bristol-Myers Squibb Company Pyridone GPR119 G protein-coupled receptor agonists
US20090105124A1 (en) 2007-08-23 2009-04-23 Kalypsys, Inc. Heterocyclic modulators of tgr5
NZ584049A (en) 2007-09-21 2011-05-27 Sanofi Aventis (carboxylalkylene-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament
RU2010115747A (ru) 2007-09-21 2011-10-27 Санофи-Авентис (Fr) (циклопропилфенил)фенилоксаламиды, способ их получения и их применения в качестве лекарственного средства
ES2401233T3 (es) 2007-10-17 2013-04-18 Universidad de Córdoba Isoformas del receptor tipo 5 de somatostatina humana producidas por tratamiento alternativo y pares de oligonucleótidos para la detección de las mismas por PCR
JP2011016722A (ja) 2007-10-23 2011-01-27 Astellas Pharma Inc チアゾリジンジオン化合物
TW200932219A (en) 2007-10-24 2009-08-01 Astellas Pharma Inc Oxadiazolidinedione compound
US8304547B2 (en) 2007-10-24 2012-11-06 Astellas Pharma Inc. Azolecarboxamide compound or salt thereof
BRPI0818687A2 (pt) 2007-10-26 2017-05-02 Japan Tobacco Inc composto espiro, o sal deste farmaceuticamente aceitavél ou o solvato deste, composição farmacêutica, medicamento agonista de gpr40, agente promotor da secreção de insulina ou um agente hipoglicêmico, uso do composto espíro, o sal deste farmaceuticamente aceitavél ou o solvato deste, e, métodos para a ativação de gpr40, para promover secreção de insulina ou diminuir o nível de glicose sanguínea, e para tratar ou prevenir uma doença.
CA2703217A1 (en) 2007-10-29 2009-05-07 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
JP5650540B2 (ja) 2007-12-12 2015-01-07 ライジェル ファーマシューティカルズ， インコーポレイテッド 代謝障害のためのカルボキサミド、スルホンアミド、およびアミン化合物
CA2716330A1 (en) 2008-02-22 2009-08-27 Irm Llc Compounds and compositions as modulators of gpr119 activity
CA2714703A1 (en) 2008-02-22 2009-08-27 Irm Llc Compounds and compositions as modulators of gpr119 activity
CN102007100A (zh) 2008-02-22 2011-04-06 Irm责任有限公司 作为gpr119活性调控剂的化合物和组合物
WO2009106561A1 (en) 2008-02-27 2009-09-03 Biovitrum Ab (Publ) Pyrazine compounds for treating gpr119 related disorders
WO2009106565A1 (en) 2008-02-27 2009-09-03 Biovitrum Ab (Publ) Agonists of gpr119
WO2009117421A2 (en) 2008-03-17 2009-09-24 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
KR20100134659A (ko) 2008-03-31 2010-12-23 메타볼렉스, 인코포레이티드 옥시메틸렌 아릴 화합물 및 그것의 사용
EP2271619A1 (en) 2008-04-07 2011-01-12 Irm Llc Compounds and compositions as modulators of gpr119 activity
KR101630466B1 (ko) 2008-04-11 2016-06-14 메르크 파텐트 게엠베하 Ａｍｐ-활성화 단백질 키나아제(ａｍｐｋ) 활성화제로서의 티에노피리돈 유도체
WO2009132136A1 (en) 2008-04-23 2009-10-29 Rigel Pharmaceuticals, Inc. Carboxamide compounds for the treatment of metabolic disorders
SI2280952T1 (sl) 2008-05-05 2012-09-28 Merck Patent Gmbh Derivati tienopiridona kot aktivatorji AMP-aktivirane protein kinaze (AMPK)
AU2009249237A1 (en) 2008-05-19 2009-11-26 Schering Corporation Bicyclic heterocycle derivatives and use thereof as GPR119 modulators
US8188098B2 (en) 2008-05-19 2012-05-29 Hoffmann-La Roche Inc. GPR119 receptor agonists
CA2728018C (en) 2008-06-16 2016-10-11 Merck Patent Gmbh Quinoxalinedione derivatives
KR20110026481A (ko) 2008-06-20 2011-03-15 메타볼렉스, 인코포레이티드 아릴 ｇｐｒ１１９ 작동약 및 이의 용도
US8215922B2 (en) 2008-06-24 2012-07-10 Aurora Sfc Systems, Inc. Compressible fluid pumping system for dynamically compensating compressible fluids over large pressure ranges
MX2011000392A (es) 2008-07-11 2011-03-01 Irm Llc 4-fenoxi-metil-piperidinas como moduladoras de la actividad de gpr119.
TW201006821A (en) 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
WO2010014739A2 (en) 2008-07-29 2010-02-04 Kalypsys, Inc. Heterocyclic modulators of tgr5
WO2010014836A2 (en) 2008-07-30 2010-02-04 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
JPWO2010013849A1 (ja) 2008-08-01 2012-01-12 日本ケミファ株式会社 Ｇｐｒ１１９作動薬
WO2010016846A1 (en) 2008-08-08 2010-02-11 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
EP2337585A1 (en) 2008-09-19 2011-06-29 Nektar Therapeutics Polymer conjugates of glp-2-like peptides
EP3924343A1 (en) 2008-09-26 2021-12-22 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
WO2010047982A1 (en) * 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010051176A1 (en) 2008-10-29 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
AU2009309037A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CA2743489A1 (en) 2008-11-17 2010-05-20 Merck Sharp & Dohme Corp. Substituted bicyclic amines for the treatment of diabetes
CN106380502A (zh) 2008-11-19 2017-02-08 英特塞普特医药品公司 G蛋白偶联受体5(tgr5)调节剂及其使用方法
EP2376519B1 (en) 2008-11-19 2013-11-13 Intercept Pharmaceuticals, Inc. Tgr5 modulators and method of use thereof
AU2009326965A1 (en) 2008-12-12 2011-06-23 Poxel Tetrahydrotriazine compounds for treating diseases associated with AMPK activity
JP2012515782A (ja) 2009-01-23 2012-07-12 シェーリング コーポレイション 抗糖尿病性架橋および縮合化合物
AU2010206786A1 (en) 2009-01-23 2011-07-28 Merck Sharp & Dohme Corp. Bridged and fused heterocyclic antidiabetic compounds
AU2010206783A1 (en) 2009-01-23 2011-07-28 Merck Sharp & Dohme Corp. Pentafluorosulpholane-containing antidiabetic compounds
AR075051A1 (es) 2009-02-05 2011-03-02 Schering Corp Compuestos antidiabeticos que contienen ftalazina
JP2012517479A (ja) 2009-02-12 2012-08-02 エグゼリクシス， インコーポレイテッド 糖尿病および肥満の処置においてｔｇｒ５アゴニストとして使用するためのトリアゾールおよびイミダゾール誘導体
EP2423176A4 (en) 2009-04-22 2012-11-07 Astellas Pharma Inc CARBOXYLIC ACID COMPOUND
JP2012136438A (ja) 2009-04-22 2012-07-19 Astellas Pharma Inc テトラゾール化合物
EP2427448A1 (en) 2009-05-08 2012-03-14 Pfizer Inc. Gpr 119 modulators
WO2010143733A1 (en) 2009-06-09 2010-12-16 Takeda Pharmaceutical Company Limited Novel fused cyclic compound and use thereof
AR077638A1 (es) 2009-07-15 2011-09-14 Lilly Co Eli Compuesto de (metanosulfonil -piperidin )-( alcoxi-aril) -tetrahidro- piridina , composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento de diabetes u obesidad
WO2011025006A1 (ja) 2009-08-31 2011-03-03 日本ケミファ株式会社 Ｇｐｒ１１９作動薬
GB0915892D0 (en) 2009-09-10 2009-10-14 Smithkline Beecham Corp Compounds
WO2011030139A1 (en) 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators
WO2011032320A1 (en) 2009-09-21 2011-03-24 F. Hoffmann-La Roche Ag Novel alkene oxindole derivatives
US8410127B2 (en) 2009-10-01 2013-04-02 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
WO2011044001A1 (en) 2009-10-09 2011-04-14 Irm Llc Compounds and compositions as modulators of gpr119 activity
AR078522A1 (es) 2009-10-15 2011-11-16 Lilly Co Eli Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis
EP2314616A1 (en) 2009-10-23 2011-04-27 Ferring B.V. Peptidic GLP-2 agonists
CA2779398A1 (en) 2009-10-30 2011-05-05 Mochida Phamaceutical Co., Ltd. Novel 3-hydroxy-5-arylisoxazole derivative
EP2504342A1 (en) 2009-11-23 2012-10-03 Pfizer Inc. Imidazo-pyrazoles as gpr119 inhibitors
AR078948A1 (es) 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
WO2011069298A1 (en) 2009-12-11 2011-06-16 F. Hoffmann-La Roche Ag Novel cyclopropane indolinone derivatives
CN102781922A (zh) 2009-12-11 2012-11-14 埃克塞利希斯股份有限公司 Tgr5激动剂
CN102712610B (zh) 2009-12-25 2015-03-04 持田制药株式会社 新的3-羟基-5-芳基异噻唑衍生物
EA020588B1 (ru) 2009-12-29 2014-12-30 Поксел ТИЕНО[2,3-b]ПИРИДИНДИОНОВЫЕ АКТИВАТОРЫ АМФК И ИХ ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US20130109703A1 (en) 2010-03-18 2013-05-02 Boehringer Ingelheim International Gmbh Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions
MX2012011460A (es) 2010-04-08 2012-11-23 Squibb Bristol Myers Co Analogos de pirimidinilpiperidiniloxipiridinona como moduladores de gpr119.
US8344137B2 (en) 2010-04-14 2013-01-01 Hoffman-La Roche Inc. 3,3-dimethyl tetrahydroquinoline derivatives
WO2011138307A1 (en) 2010-05-05 2011-11-10 Glaxosmithkline Llc Pyrrolo [3, 2 -d] pyrimidin-3 -yl derivatives used as activators of ampk
EA201270778A1 (ru) 2010-05-06 2013-04-30 Бристол-Майерс Сквибб Компани Бициклические гетероарильные аналоги в качестве модуляторов рецептора gpr119
EP2566862B1 (en) 2010-05-06 2015-09-16 Bristol-Myers Squibb Company Benzofuranyl analogues as gpr119 modulators
JP5794297B2 (ja) 2010-05-07 2015-10-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｇｐｒ１１９アゴニストとしてのピリダジノン
AU2011256455A1 (en) 2010-05-17 2013-01-10 Array Biopharma Inc. Piperidinyl-substituted lactams as GPR119 modulators
AU2011256444B2 (en) 2010-05-18 2014-07-10 Merck Sharp & Dohme Corp. Spiro isoxazoline compounds as SSTR5 antagonists
TW201209054A (en) 2010-05-28 2012-03-01 Prosidion Ltd Novel compounds
WO2011150067A1 (en) 2010-05-28 2011-12-01 Glaxosmithkline Llc Treatment of blood lipid abnormalities and other conditions
WO2011153435A1 (en) 2010-06-04 2011-12-08 Metabolex, Inc. Preparation of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
CN103037843A (zh) 2010-06-23 2013-04-10 麦它波莱克斯股份有限公司 5-乙基-2-{4-[4-(4-四唑-1-基-苯氧甲基)-噻唑-2-基]-哌啶-1-基}-嘧啶的组合物
US8592594B2 (en) 2010-07-02 2013-11-26 Hoffmann-La Roche Inc. Tetrahydro-quinoline derivatives
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2012011125A1 (en) 2010-07-23 2012-01-26 Connexios Life Sciences Pvt. Ltd. Agonists of gpr40
ES2823350T3 (es) 2010-07-29 2021-05-06 Rigel Pharmaceuticals Inc Compuestos heterocíclicos que activan AMPK y métodos de uso de los mismos
EP2605658B1 (en) 2010-08-18 2016-03-23 Merck Sharp & Dohme Corp. Spiroxazolidinone compounds
WO2012025811A1 (en) 2010-08-23 2012-03-01 Lupin Limited Indolylpyrimidines as modulators of gpr119
US20120053180A1 (en) 2010-08-27 2012-03-01 Chemizon, A Division Of Optomagic Co., Ltd. Cyclohexane analogues as gpr119 agonists
JP5908478B2 (ja) 2010-08-30 2016-04-26 エヌピーエス ファーマシューティカルズ インコーポレイテッドＮｐｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ｈ「Ｇｌｙ２」ＧＬＰ−２の固相合成
JP5641663B2 (ja) 2010-09-10 2014-12-17 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有するヘテロ環縮合イミダゾール誘導体
CA2811525A1 (en) 2010-09-17 2012-03-22 Array Biopharma Inc. Piperidinyl-substituted lactams as gpr119 modulators
ES2551183T3 (es) 2010-10-08 2015-11-16 Cadila Healthcare Limited Nuevos agonistas de GPR 119
JP2014001144A (ja) 2010-10-08 2014-01-09 Nippon Chemiphar Co Ltd Ｇｐｒ１１９作動薬
US9040525B2 (en) 2010-10-08 2015-05-26 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
DK2646425T3 (en) 2010-12-01 2015-08-24 Boehringer Ingelheim Int Indanyloxydihydrobenzofuranylacetic acids useful for the treatment of metabolic syndrome.
WO2012077655A1 (ja) 2010-12-07 2012-06-14 塩野義製薬株式会社 Ｇｐｒ１１９アゴニスト活性を有するスピロ誘導体
WO2012082947A1 (en) 2010-12-16 2012-06-21 Irm Llc Compounds and compositions as tgr5 agonists
UY33805A (es) 2010-12-17 2012-07-31 Boehringer Ingelheim Int ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?.
KR20140003496A (ko) 2011-01-21 2014-01-09 베링거 인겔하임 인터내셔날 게엠베하 당뇨병, 비만 및 관련 질환들을 치료하기 위한, ｇｐｒ１１９ 조절제로서의 융합된 디하이드로푸란
US8809369B2 (en) 2011-01-26 2014-08-19 Hoffmann-La Roche Inc. Tetrahydroquinoline derivatives
CN102617548A (zh) 2011-01-31 2012-08-01 北京赛林泰医药技术有限公司 作为gpr受体激动剂的双环杂芳基化合物及其组合物和应用
SG192645A1 (en) 2011-02-17 2013-09-30 Takeda Pharmaceutical Production method of optically active dihydrobenzofuran derivative
MY159058A (en) * 2011-02-25 2016-12-15 Merck Sharp & Dohme Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agent
JP2014094886A (ja) 2011-02-28 2014-05-22 Nippon Chemiphar Co Ltd Ｇｐｒ１１９作動薬
WO2012119978A1 (en) 2011-03-07 2012-09-13 Glaxosmithkline Llc Quinolinone derivatives
US20130345243A1 (en) 2011-03-07 2013-12-26 Glaxosmithkline Llc 1h-pyrollo[3,2-d]pyrimidinedione derivatives
WO2012138919A2 (en) 2011-04-08 2012-10-11 Amgen Inc. Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
WO2012145361A1 (en) 2011-04-19 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140051714A1 (en) 2011-04-22 2014-02-20 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
NZ617409A (en) 2011-04-27 2015-08-28 Mochida Pharm Co Ltd Novel 3-hydroxyisothiazole 1-oxide derivative
CN103619817A (zh) 2011-04-28 2014-03-05 百时美施贵宝公司 新颖的二环含氮杂芳基tgr5受体调节剂
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013054338A1 (en) 2011-07-06 2013-04-18 Cadila Healthcare Limited 2-thio-imidazole derivatives as tgr5 modulators
US9567330B2 (en) 2011-07-15 2017-02-14 Shionogi & Co., Ltd. Azabenzimidazole derivative having AMPK-activating activity
TWI537262B (zh) 2011-08-17 2016-06-11 美國禮來大藥廠 供治療糖尿病使用之新穎１，２，３，４－四氫喹啉衍生物
BR112014005744B1 (pt) 2011-09-12 2020-11-17 Amunix Operating Inc. proteína de fusão recombinante, composição farmacêutica compreendendo a referida proteína e uso da mesma referência cruzada com pedido relacionado
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013057743A1 (en) 2011-10-21 2013-04-25 Connexios Life Sciences Pvt. Ltd Process for the preparation of an aryl oxime and salts thereof
US20140256756A1 (en) 2011-11-03 2014-09-11 Array Biopharma Inc. Piperidinyl-substituted lactams as gpr119 modulators
WO2013074388A1 (en) 2011-11-15 2013-05-23 Merck Sharp & Dohme Corp. Substituted cyclopropyl compounds useful as gpr119 agonists
IN2014MN01433A (es) 2011-12-21 2015-07-03 Ardelyx Inc
CN103429581B (zh) 2012-01-12 2015-08-26 江苏恒瑞医药股份有限公司 多环类衍生物、其制备方法及其在医药上的应用
JP6121339B2 (ja) 2012-02-13 2017-04-26 武田薬品工業株式会社 芳香環化合物
US9382188B2 (en) 2012-02-13 2016-07-05 Takeda Pharmaceutical Company Limited Aromatic ring compound
WO2013122821A1 (en) 2012-02-14 2013-08-22 Merck Sharp & Dohme Corp. Substituted cyclopropyl compounds useful as gpr119 agonists
WO2013128378A1 (en) 2012-02-28 2013-09-06 Piramal Enterprises Limited Phenyl alkanoic acid derivatives as gpr agonists
US8642585B2 (en) 2012-03-26 2014-02-04 Boehringer Ingelheim International Gmbh Indanyloxydihydrobenzofuranylacetic acids
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
WO2013154163A1 (ja) 2012-04-11 2013-10-17 持田製薬株式会社 新規５－アリール－１，２－チアジナン誘導体
US8809376B2 (en) 2012-04-30 2014-08-19 Boehringer Ingelheim International Gmbh Indanyloxydihydrobenzofuranylacetic acids
AU2013255752B2 (en) 2012-05-03 2017-11-09 Zealand Pharma A/S Glucagon-like-peptide-2 (GLP-2) analogues
WO2013167514A1 (en) 2012-05-07 2013-11-14 Boehringer Ingelheim International Gmbh New 2,3-dihydro-furo[2,3-c]pyridines, their use as modulators of the g-protein-coupled receptor gpr119 and pharmaceutical compositions comprising them
WO2013173198A1 (en) 2012-05-16 2013-11-21 Bristol-Myers Squibb Company Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators
US8633182B2 (en) 2012-05-30 2014-01-21 Boehringer Ingelheim International Gmbh Indanyloxyphenylcyclopropanecarboxylic acids
EP2679591A1 (en) 2012-06-29 2014-01-01 Poxel Thienopyridone derivatives useful as activators of AMPK
WO2014019186A1 (en) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP2888006B1 (en) 2012-08-22 2019-04-24 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydropyran derivatives useful as ampk activators
EP2887807B1 (en) 2012-08-22 2019-09-18 Merck Sharp & Dohme Corp. Benzimidazole hexahydrofuro[3,2-b]furan derivatives useful as amp-activated protein kinase activators
WO2014031441A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel benzimidazole tetrahydrofuran derivatives
US9290517B2 (en) 2012-08-22 2016-03-22 Merck Sharp & Dohme Corp. Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives
US9527839B2 (en) 2012-08-22 2016-12-27 Merck Sharp & Dohme Corp. Benzimidazole tetrahydropyran derivatives
EP2888008B1 (en) 2012-08-22 2018-12-26 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydrofuran derivatives
WO2014052619A1 (en) 2012-09-27 2014-04-03 Irm Llc Piperidine derivatives and compositions as modulators of gpr119 activity
AR092924A1 (es) 2012-10-09 2015-05-06 Sanofi Sa Derivados de pirrolidinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados
US9777038B2 (en) 2012-10-26 2017-10-03 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives
WO2014069426A1 (ja) 2012-10-31 2014-05-08 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有するベンズイミダゾールおよびアザベンズイミダゾール誘導体
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
TWI692469B (zh) 2012-11-09 2020-05-01 南韓商Ｌｇ化學股份有限公司 Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物
KR20150088878A (ko) 2012-11-28 2015-08-03 베링거 인겔하임 인터내셔날 게엠베하 신규한 인다닐옥시디하이드로벤조푸라닐아세트산
RU2693382C2 (ru) 2012-11-28 2019-07-02 Интерсепт Фармасьютикалз, Инк. Лечение заболевания дыхательной системы
JP6283862B2 (ja) 2012-12-07 2018-02-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規インダニルオキシジヒドロベンゾフラニル酢酸
WO2014100021A1 (en) 2012-12-17 2014-06-26 Exelixis, Inc. Tgr5 agonists: imidazole and triazole compounds containing a quaternary nitrogen
WO2014100025A1 (en) 2012-12-17 2014-06-26 Exelixis, Inc. Tgr5 agonists having an imidazole or triazole core with subtituent having a quaternary nitrogen
WO2014096440A2 (en) 2012-12-21 2014-06-26 Novozymes Biopharma Dk A/S Composition
WO2014122067A1 (en) 2013-02-06 2014-08-14 Boehringer Ingelheim International Gmbh New indanyloxydihydrobenzofuranylacetic acids
EP2769974A1 (en) 2013-02-21 2014-08-27 Debiopharm S.A. Novel AMPK activator
US9840512B2 (en) 2013-02-22 2017-12-12 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US9890119B2 (en) 2013-02-27 2018-02-13 Shionogi & Co., Ltd. Indole and azaindole derivative having AMPK-activating activity
CN104059039B (zh) 2013-03-22 2017-03-15 正大天晴药业集团股份有限公司 具有gpr40受体功能调节作用的稠环化合物
CN104109115B (zh) 2013-04-16 2016-11-23 中国科学院上海药物研究所 一种含氮杂环链接的苯丙酸类化合物、其药物组合物、制备方法和用途
WO2014170842A2 (en) 2013-04-17 2014-10-23 Piramal Enterprises Limited Substituted alkyl carboxylic acid derivatives as gpr agonists
JP6372891B2 (ja) 2013-04-24 2018-08-15 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有する５−オキシベンズイミダゾールおよび５−オキシアザベンズイミダゾール誘導体
CN104870429B (zh) 2013-05-22 2017-05-03 四川海思科制药有限公司 苯并呋喃衍生物、其制备方法及其在医药上的应用
KR20160034893A (ko) 2013-06-13 2016-03-30 패스트 포워드 파머슈티컬스 비.브이. Cd40 시그널링 억제제 및 추가 화합물로서, 상기 추가 화합물은 담즙산, 담즙산 유도체, tgr5-수용체 아고니스트, fxr 아고니스트 또는 이들의 조합이고, 만성 염증의 치료용, 및 위장 암 또는 섬유증의 예방용인, cd40 시그널링 억제제 및 추가 화합물
WO2014202528A1 (en) 2013-06-20 2014-12-24 Boehringer Ingelheim International Gmbh Olefin substituted oxindoles having ampk activity
EP3010905A1 (en) 2013-06-20 2016-04-27 Boehringer Ingelheim International GmbH Spiro-substituted oxindole derivatives having ampk activity
WO2015000412A1 (zh) 2013-07-02 2015-01-08 四川海思科制药有限公司 苯并环丁烯类衍生物、其制备方法及其在医药上的应用
PL3022210T3 (pl) 2013-07-17 2018-08-31 Boehringer Ingelheim International Gmbh Nowy pochodne azabenzimidazolu
CN105143181B (zh) 2013-07-26 2017-12-26 四川海思科制药有限公司 三元并环羧酸类衍生物、其制备方法及其在医药上的应用
PL3027642T3 (pl) 2013-07-31 2021-01-11 Amgen Inc. Konstrukty czynnika różnicowania wzrostu 15 (GDF-15)
EP3031799B1 (en) 2013-08-09 2018-04-04 Takeda Pharmaceutical Company Limited Aromatic compound
CN104418801B (zh) 2013-08-19 2016-10-05 上海润诺生物科技有限公司 苯并哌啶环与苯并吗啉环类化合物、其制法及医药应用
CN105473595A (zh) 2013-08-23 2016-04-06 福建海西新药创制有限公司 治疗糖尿病的羧酸化合物
WO2015028960A1 (en) 2013-08-28 2015-03-05 Piramal Enterprises Limited Substituted heterocyclic derivatives as gpr agonists and uses thereof
CN105246875A (zh) 2013-09-03 2016-01-13 四川海思科制药有限公司 茚满衍生物及其制备方法和在医药上的应用
WO2015044073A1 (en) 2013-09-26 2015-04-02 Boehringer Ingelheim International Gmbh Process and intermediates for preparing indanyloxydihydrobenzofuranyl acetic acid derivatives as gpr40 agonists
JO3442B1 (ar) 2013-10-07 2019-10-20 Takeda Pharmaceuticals Co مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP3063148B1 (en) 2013-10-31 2020-04-29 Boehringer Ingelheim International GmbH Azabenzimidazole derivatives
WO2015062486A1 (en) 2013-10-31 2015-05-07 Sunshine Lake Pharma Co., Ltd. Biphenyl compounds and uses thereof
EA201690888A1 (ru) 2013-11-14 2016-10-31 Кадила Хелзкэр Лимитед Новые гетероциклические соединения
ES2747973T3 (es) 2013-11-15 2020-03-12 Merck Sharp & Dohme Compuestos tricíclicos antidiabéticos
EP3074384B1 (en) 2013-11-26 2019-05-22 Chong Kun Dang Pharmaceutical Corp. Amide derivatives for gpr119 agonist
EP3074375B1 (en) 2013-11-28 2018-04-04 Boehringer Ingelheim International GmbH New indanyloxyphenylcyclopropanecarboxylic acids
US9957219B2 (en) 2013-12-04 2018-05-01 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
TW201609722A (zh) 2013-12-13 2016-03-16 美國禮來大藥廠 新穎三唑并吡啶化合物
EP2886541A1 (en) 2013-12-19 2015-06-24 Sanofi Oxindole derivatives, preparation thereof and therapeutic use in the treatment of AMPK-related diseases
WO2015089809A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
JP6170255B2 (ja) 2014-01-10 2017-07-26 イーライ リリー アンド カンパニー イソプロピルトリアゾロピリジン化合物
JP6211200B2 (ja) 2014-01-10 2017-10-11 イーライ リリー アンド カンパニー フェニル−トリアゾロ−ピリジン化合物
EP3102198B1 (en) 2014-02-06 2020-08-26 Merck Sharp & Dohme Corp. Antidiabetic compounds
AR099936A1 (es) 2014-04-04 2016-08-31 Sanofi Sa Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados
TW201623286A (zh) 2014-04-04 2016-07-01 賽諾菲公司 作為ｇｐｒ１１９調控劑用於治療糖尿病、肥胖、血脂異常及相關病症之異吲哚啉酮化合物
CN106132949A (zh) 2014-04-04 2016-11-16 赛诺菲 作为治疗糖尿病、肥胖、血脂障碍及相关病症的gpr119调节剂的取代的茚满酮化合物
WO2015160772A1 (en) 2014-04-15 2015-10-22 Janssen Pharmaceutica Nv Tetrahydro-benzoimidazolyl modulators of tgr5
MX2016014642A (es) 2014-05-09 2017-05-25 Kineta Inc Compuestos y composiciones farmaceuticas antivirales, asi como metodos de uso de los mismos.
WO2015176267A1 (en) 2014-05-22 2015-11-26 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US10166246B2 (en) 2014-05-27 2019-01-01 City Of Hope TGR5 agonist complexes for treating diabetes and cancer
MA39881B1 (fr) 2014-05-29 2020-02-28 Bar Pharmaceuticals S R L Dérivés de cholane à utiliser dans le traitement et/ou la prévention de maladies médiées par fxr et tgr5/gpbar1
EP3157947A1 (en) 2014-06-23 2017-04-26 Novartis AG Hsa-gdf-15 fusion polypeptide and use thereof
WO2016001224A1 (en) 2014-06-30 2016-01-07 Debiopharm International S.A. Novel activators of amp-activated protein kinases
EP3164538A1 (en) 2014-07-02 2017-05-10 Arçelik Anonim Sirketi Built-in household appliance unpowered control and status indication device
EP3177287B1 (en) 2014-08-08 2022-02-23 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US10662171B2 (en) 2014-08-08 2020-05-26 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US10100042B2 (en) 2014-08-08 2018-10-16 Merck Sharp & Dohme Corp. [5,6]—fused bicyclic antidiabetic compounds
WO2016019587A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [7, 6]-fused bicyclic antidiabetic compounds
WO2016023789A1 (en) 2014-08-11 2016-02-18 Boehringer Ingelheim International Gmbh Azabenzimidazole derivatives as amp protein kinase agonistes
MX2017002275A (es) 2014-08-27 2017-05-03 Shionogi & Co Derivado de azaindol que tiene actividad activadora de proteina cinasa activada por monofosfato de adenosina (ampk).
WO2016032120A1 (ko) 2014-08-27 2016-03-03 씨제이헬스케어 주식회사 신규한 아미노-페닐-설포닐-아세테이트 유도체 및 이의 용도
WO2016054208A1 (en) 2014-10-03 2016-04-07 Mayo Foundation For Medical Education And Research Targeting tgr5 to treat disease
TW201629033A (zh) 2014-10-08 2016-08-16 健生藥品公司 作為治療第二型糖尿病之ｇｐｒ４０促效劑的經取代苯并噻吩基衍生物
WO2016068453A1 (en) 2014-10-27 2016-05-06 Dong-A St Co., Ltd. Compound having gpr119 agonistic activity, method for preparing the same, and pharmaceutical composition including the same as effective component
WO2016068099A1 (ja) 2014-10-28 2016-05-06 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有する複素環誘導体
JP2017537894A (ja) 2014-10-31 2017-12-21 グブラ エーピーエス Ｇｌｐ−１ｒおよびｇｌｐ−２ｒ二重アゴニスト活性を有する組成物及びペプチド
US10266560B2 (en) 2014-11-06 2019-04-23 Enanta Pharmaceuticals, Inc. Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
US11578097B2 (en) 2014-11-26 2023-02-14 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof
WO2016092413A1 (en) 2014-12-10 2016-06-16 Pfizer Inc. Indole and indazole compounds that activate ampk
JP6612880B2 (ja) 2015-01-16 2019-11-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ａｍｐ活性化タンパク質キナーゼのアゴニストとしての新規アザベンゾイミダゾール誘導体
EP3245212B1 (en) 2015-01-16 2019-03-13 Boehringer Ingelheim International GmbH New azabenzimidazole derivatives
RU2017130466A (ru) 2015-02-11 2019-03-12 Энанта Фармасьютикалс, Инк. Аналоги желчной кислоты в качестве агонистов fxr/tgr5 и способы их применения
ES2886766T3 (es) 2015-03-31 2021-12-20 Enanta Pharm Inc Derivados del ácido biliar como agonistas de FXR/TGR5 y métodos de uso de estos
TW201712012A (zh) 2015-06-16 2017-04-01 美國禮來大藥廠 ２－側氧基－１，３，８－三氮雜螺［４．５］癸－３－基羧酸衍生物
AU2016280806B2 (en) 2015-06-19 2021-01-28 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
WO2017002786A1 (ja) 2015-07-02 2017-01-05 サントリーホールディングス株式会社 Ｇｌｐ－２分泌促進用組成物
US9617251B2 (en) 2015-08-07 2017-04-11 Boehringer Ingelheim International Gmbh Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
CA2994687A1 (en) 2015-08-07 2017-02-16 Intercept Pharmaceuticals, Inc. Methods for preparation of bile acids and derivatives thereof
WO2017027309A1 (en) 2015-08-12 2017-02-16 Janssen Pharmaceutica Nv Gpr40 agonists for the treatment of type ii diabetes
US9856245B2 (en) 2015-08-12 2018-01-02 Janssen Pharmaceutica Nv GPR40 agonists for the treatment of type II diabetes
US9908873B2 (en) 2015-08-12 2018-03-06 Janssen Pharmaceutica Nv GPR40 agonists for the treatment of type II diabetes
EP3347358B1 (en) 2015-09-09 2019-11-27 Boehringer Ingelheim International GmbH [{[2,3-dihydro-1h-inden-1-yl]amino}-2h,3h-furo[3,2-b]pyridin-3-yl]acetic acids, pharmaceutical compositions and uses thereof
EP3353189A4 (en) 2015-09-24 2019-06-19 Intercept Pharmaceuticals, Inc. METHODS AND INTERMEDIATES FOR PREPARING BILARY ACID DERIVATIVES
CA3004275A1 (en) 2015-11-06 2017-05-11 Intercept Pharmaceuticals, Inc. Methods for the preparation of obeticholic acid and derivatives thereof
WO2017106112A1 (en) 2015-12-16 2017-06-22 Merck Sharp & Dohme Corp. Methods of preventing or treating hypoglycemia by administering a gpr119 agonist
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物
WO2017147137A1 (en) 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof
WO2017147174A1 (en) 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof
US10364267B2 (en) 2016-02-23 2019-07-30 Enanta Pharmaceuticals, Inc. Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
JPWO2017146186A1 (ja) 2016-02-26 2018-12-20 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有する５−フェニルアザインドール誘導体
JP2019510739A (ja) 2016-02-29 2019-04-18 イーライ リリー アンド カンパニー Ｇｆｒａｌ受容体療法
WO2017172505A1 (en) 2016-03-29 2017-10-05 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US10526345B2 (en) 2016-04-08 2020-01-07 Mankind Pharma Ltd. Compounds as GPR119 agonists
US10208030B2 (en) 2016-04-08 2019-02-19 Mankind Pharma Ltd. GPR119 agonist compounds
US10106553B2 (en) 2016-04-11 2018-10-23 Janssen Pharmaceutica Nv Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
CA3020698A1 (en) 2016-04-13 2017-10-19 Intercept Pharmaceuticals, Inc. Methods of treating or preventing hepatocellular carcinoma
CN109311912A (zh) 2016-04-26 2019-02-05 盐野义制药株式会社 具有ampk活化作用的5-取代氮杂苯并咪唑衍生物
CN109476661A (zh) 2016-05-20 2019-03-15 盐野义制药株式会社 具有ampk活化作用的5-取代苯并咪唑及5-取代氮杂苯并咪唑衍生物
WO2017222713A1 (en) 2016-06-24 2017-12-28 Indiana University Research & Technology Corporation A gpr119-based signaling system in the murine eye regulates intraocular pressure in a sex-dependent manner
US11236055B2 (en) 2016-07-01 2022-02-01 Venenum Biodesign, LLC Non-systemic TGR5 agonists
US10654834B2 (en) 2016-07-01 2020-05-19 Venenum Biodesign, LLC Non-systemic TGR5 agonists
WO2018009778A1 (en) 2016-07-07 2018-01-11 Baylor College Of Medicine Combination of glp-1 and glp-2 for treating or preventing metabolic diseases, disorders and syndromes
KR20190035752A (ko) 2016-08-03 2019-04-03 사이머베이 쎄라퓨틱스, 인코퍼레이티드 염증성 위장 질환 또는 위장 상태를 치료하기 위한 옥시메틸렌 아릴 화합물
EP3500558B1 (en) 2016-08-19 2022-11-02 Rigel Pharmaceuticals, Inc. Benzimidazole direct ampk activators
WO2018064441A1 (en) 2016-09-30 2018-04-05 Intercept Pharmaceuticals, Inc Crystalline forms of a bile acid derivative
CA3038846A1 (en) 2016-10-12 2018-04-19 Janssen Biotech, Inc. Methods for screening for modulators of gdf15-like biological activity
WO2018081047A1 (en) 2016-10-25 2018-05-03 Janssen Pharmaceutica Nv Cyclohexyl gpr40 agonists for the treatment of type ii diabetes
WO2018077699A1 (en) 2016-10-25 2018-05-03 Boehringer Ingelheim International Gmbh Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
EP3544958B1 (en) 2016-11-28 2021-03-24 Boehringer Ingelheim International GmbH Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
CA3044915A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Glp-1/glp-2 dual agonists
WO2018104559A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Glp-1/glp-2 dual agonists
KR102502040B1 (ko) 2016-12-09 2023-02-24 질랜드 파마 에이/에스 아실화 glp-1/glp-2 이중 효능제
WO2018103868A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Acylated glp-1/glp-2 dual agonists
WO2018104558A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Acylated glp-1/glp-2 dual agonists
KR102007633B1 (ko) 2016-12-15 2019-08-06 일동제약(주) 신규 페닐 프로피온 산 유도체 및 이의 용도
EP3558298A4 (en) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. ANTIDIABETIC SPIROCHROMAN COMPOUNDS
EP3573953A1 (en) 2017-01-26 2019-12-04 Boehringer Ingelheim International GmbH Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
US10253004B2 (en) 2017-01-26 2019-04-09 Boehringer Ingelheim International Gmbh Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
CN110177773B (zh) 2017-01-26 2023-08-25 勃林格殷格翰国际有限公司 苄基氨基吡啶基环丙烷羧酸、其药物组合物及其用途
CN110312714B (zh) 2017-01-26 2022-12-09 勃林格殷格翰国际有限公司 苄基氧基吡嗪基环丙烷甲酸、其药物组合物和用途
US10793530B2 (en) 2017-01-26 2020-10-06 Boehringer Ingelheim International Gmbh Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
WO2018142363A1 (en) 2017-02-06 2018-08-09 Orbicular Pharmaceutical Technologies Private Limited Ready to use compositions of glp-2 analogues through self-administrable devices
US10550127B1 (en) 2017-02-08 2020-02-04 Boehringer Ingelheim International Gmbh Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes
WO2018153849A1 (en) 2017-02-21 2018-08-30 Sanofi Azetidine compounds as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders
WO2018161077A1 (en) 2017-03-03 2018-09-07 The Regents Of The University Of California Methods of treating conditions associated with leaky gut barrier
GB201704714D0 (en) 2017-03-24 2017-05-10 Caldan Therapeutics Ltd Pharmaceutical compounds
WO2018181847A1 (ja) 2017-03-31 2018-10-04 武田薬品工業株式会社 芳香環化合物
AR111199A1 (es) 2017-03-31 2019-06-12 Takeda Pharmaceuticals Co Compuesto aromático agonista de gpr40
IT201700039329A1 (it) 2017-04-10 2018-10-10 Univ Pisa Derivati benzofuranici quali attivatori di ampk
IT201700039562A1 (it) 2017-04-10 2018-10-10 Univ Pisa Derivati isoindolinici quali attivatori di ampk
CN107162921B (zh) 2017-05-27 2019-12-13 中国药科大学 一类苯氧乙酸衍生物、其制备方法及其作为药物的用途
WO2018222701A1 (en) 2017-05-30 2018-12-06 Intercept Pharmaceuticals, Inc. Treatment of renal diseases with a bile acid derivative
WO2018226724A1 (en) 2017-06-05 2018-12-13 Intercept Pharmaceuticals, Inc. Treatment and prevention of diabetic eye diseases with a bile acid derivatives
SG11201912161SA (en) 2017-06-16 2020-01-30 Zealand Pharma As Dosage regimes for the administration of glucagon-like-peptide-2 (glp-2) analogues
IL271343B2 (en) 2017-06-23 2023-12-01 Intercept Pharmaceuticals Inc Methods and intermediates for the preparation of bile acid derivatives
BR112020003736A2 (pt) 2017-08-22 2020-09-08 Shire-Nps Pharmaceuticals, Inc. polipeptídeos de fusão de glp-2 e usos para tratar e prevenir condições gastrointestinais
WO2019086559A1 (fr) 2017-10-31 2019-05-09 Adocia Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
MX2020004620A (es) 2017-11-06 2020-10-12 Shire Nps Pharmaceuticals Inc Analogos y pepticuerpos de peptido 2 similar a glucagon (glp-2) para administracion antes, durante o despues de cirugia.
EP3709995A4 (en) 2017-11-16 2021-04-14 Merck Sharp & Dohme Corp. BICYCLIC ANTIDIABETIC COMPOUNDS
FI3737470T3 (fi) 2018-01-08 2023-03-19 Celon Pharma Sa 3-fenyyli-4-heksyylihappojohdannaisia GPR40-agonisteina
CN113784708A (zh) 2019-05-15 2021-12-10 雀巢产品有限公司 菲ampk活化剂化合物、组合物、方法及其用途
KR20230012597A (ko) 2020-05-19 2023-01-26 칼리오페, 인크. Ampk 활성화제
AU2021297323A1 (en) 2020-06-26 2023-02-16 Kallyope, Inc. AMPK activators
WO2023097187A1 (en) 2021-11-23 2023-06-01 Kallyope, Inc. Ampk activators
WO2023097189A1 (en) 2021-11-23 2023-06-01 Kallyope, Inc. Ampk activators
WO2023097190A1 (en) 2021-11-23 2023-06-01 Kallyope, Inc. Ampk activators

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