MX2019001185A - Polipeptidos inmunomoduladores y composiciones y metodos relacionados. - Google Patents
Polipeptidos inmunomoduladores y composiciones y metodos relacionados.Info
- Publication number
- MX2019001185A MX2019001185A MX2019001185A MX2019001185A MX2019001185A MX 2019001185 A MX2019001185 A MX 2019001185A MX 2019001185 A MX2019001185 A MX 2019001185A MX 2019001185 A MX2019001185 A MX 2019001185A MX 2019001185 A MX2019001185 A MX 2019001185A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- engineered
- methods
- polypeptides
- immunomodulatory
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 3
- 102000019034 Chemokines Human genes 0.000 abstract 2
- 108010012236 Chemokines Proteins 0.000 abstract 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 108010083359 Antigen Receptors Proteins 0.000 abstract 1
- 102000006306 Antigen Receptors Human genes 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 238000011467 adoptive cell therapy Methods 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 230000001965 increasing effect Effects 0.000 abstract 1
- 230000002688 persistence Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57554—Prolactin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Transplantation (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
En la presente se proporcionan polipéptidos inmunomoduladores que contienen una primera y una segunda subunidades de una citocina o una quimiocina conectada por una región de unión que contiene un resto dirigido que se une a una molécula objetivo. En algunos aspectos, la descripción se refiere adicionalmente a células modificadas y composiciones que comprenden los polipéptidos inmunomoduladores, así como métodos para su administración a los sujetos. En algunas modalidades, las células modificadas para contener el polipéptido inmunomodulador, tales como las células T, contienen adicionalmente un receptor de antígeno modificado genéticamente que se une específicamente a los antígenos, tal como un receptor de antígeno quimérico (CAR). En algunas modalidades, las características de los polipéptidos, las células modificadas y los métodos proporcionan un tratamiento mejorado de enfermedades o trastornos, tal como la reducción de los efectos adversos de la terapia con citocinas o quimiocinas, o el aumento de la actividad, la eficacia y/o la persistencia o la disminución de la inmunogenicidad de la terapia de células adoptivas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662369017P | 2016-07-29 | 2016-07-29 | |
| PCT/US2017/044549 WO2018023093A1 (en) | 2016-07-29 | 2017-07-28 | Immunomodulatory polypeptides and related compositions and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019001185A true MX2019001185A (es) | 2019-10-21 |
Family
ID=59631857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001185A MX2019001185A (es) | 2016-07-29 | 2017-07-28 | Polipeptidos inmunomoduladores y composiciones y metodos relacionados. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20190194283A1 (es) |
| EP (1) | EP3490585B1 (es) |
| JP (2) | JP7295795B2 (es) |
| CN (1) | CN110087672A (es) |
| AU (1) | AU2017301880C1 (es) |
| CA (1) | CA3031955A1 (es) |
| ES (1) | ES2951552T3 (es) |
| MA (1) | MA45779A (es) |
| MX (1) | MX2019001185A (es) |
| WO (1) | WO2018023093A1 (es) |
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| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| AU2018298063A1 (en) | 2017-07-03 | 2020-02-20 | Torque Therapeutics, Inc. | Polynucleotides encoding immunostimulatory fusion molecules and uses thereof |
| BR112020018534A2 (pt) * | 2018-03-14 | 2020-12-29 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Imunoterapia com células t direcionadas por zetacina alvejada por receptor alfa 2 da il-13 |
| AU2019271149B2 (en) * | 2018-05-14 | 2023-07-13 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides and methods of use thereof |
| US11319380B2 (en) | 2018-06-04 | 2022-05-03 | Precigen, Inc. | MUC16 specific chimeric antigen receptors and uses thereof |
| CN109306016B (zh) * | 2018-08-15 | 2021-10-22 | 华东师范大学 | 共表达细胞因子il-7的nkg2d-car-t细胞及其用途 |
| WO2020051493A1 (en) * | 2018-09-07 | 2020-03-12 | Unum Therapeutics Inc. | Chimeric receptor polypeptides in combination with trans metabolism molecules modulating intracellular lactate concentrations and therapeutic uses thereof |
| WO2020181983A1 (zh) * | 2019-03-12 | 2020-09-17 | 重庆精准生物技术有限公司 | 缺氧调控启动子及其应用 |
| CN111848811A (zh) * | 2019-04-27 | 2020-10-30 | 张晋宇 | 一种蛋白质异二聚体及其用途 |
| CA3141459A1 (en) | 2019-05-17 | 2020-11-26 | Xencor, Inc. | Il-7-fc-fusion proteins |
| CN112294760A (zh) * | 2019-07-26 | 2021-02-02 | 张晋宇 | 一种液体制剂及其应用 |
| US20230312685A1 (en) * | 2019-10-25 | 2023-10-05 | Mayo Foundation For Medical Education And Research | Bi-Peptide with Affinity to Extracellular Matrix Proteins or Cells and to Growth Factors for Tissue Healing and Regeneration |
| WO2021115333A1 (zh) * | 2019-12-10 | 2021-06-17 | 苏州克睿基因生物科技有限公司 | 一种融合蛋白及表达此蛋白的工程化免疫细胞及其应用 |
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| AU2020425816A1 (en) * | 2020-01-30 | 2022-08-04 | Purdue Research Foundation | Ligand-mediated delivery of therapeutic proteins and the uses thereof |
| CN111533785B (zh) * | 2020-02-11 | 2022-03-08 | 北京市肿瘤防治研究所 | 靶向免疫检查点tim3结合肽及其应用 |
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| JP6603209B2 (ja) * | 2013-05-10 | 2019-11-06 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
| US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
-
2017
- 2017-07-28 AU AU2017301880A patent/AU2017301880C1/en active Active
- 2017-07-28 EP EP17752521.9A patent/EP3490585B1/en active Active
- 2017-07-28 MX MX2019001185A patent/MX2019001185A/es unknown
- 2017-07-28 ES ES17752521T patent/ES2951552T3/es active Active
- 2017-07-28 US US16/320,075 patent/US20190194283A1/en active Pending
- 2017-07-28 MA MA045779A patent/MA45779A/fr unknown
- 2017-07-28 WO PCT/US2017/044549 patent/WO2018023093A1/en unknown
- 2017-07-28 CA CA3031955A patent/CA3031955A1/en active Pending
- 2017-07-28 JP JP2019504812A patent/JP7295795B2/ja active Active
- 2017-07-28 CN CN201780058404.8A patent/CN110087672A/zh active Pending
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2023
- 2023-02-20 JP JP2023024001A patent/JP2023062104A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019531704A (ja) | 2019-11-07 |
| JP7295795B2 (ja) | 2023-06-21 |
| EP3490585A1 (en) | 2019-06-05 |
| MA45779A (fr) | 2019-06-05 |
| AU2017301880C1 (en) | 2022-04-21 |
| AU2017301880A1 (en) | 2019-02-07 |
| US20190194283A1 (en) | 2019-06-27 |
| CA3031955A1 (en) | 2018-02-01 |
| ES2951552T3 (es) | 2023-10-23 |
| EP3490585B1 (en) | 2023-05-17 |
| AU2017301880B2 (en) | 2021-11-04 |
| JP2023062104A (ja) | 2023-05-02 |
| WO2018023093A1 (en) | 2018-02-01 |
| CN110087672A (zh) | 2019-08-02 |
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