MA54118A - Polythérapie utilisant une thérapie cellulaire adoptive et un inhibiteur de point de contrôle - Google Patents

Polythérapie utilisant une thérapie cellulaire adoptive et un inhibiteur de point de contrôle

Info

Publication number
MA54118A
MA54118A MA054118A MA54118A MA54118A MA 54118 A MA54118 A MA 54118A MA 054118 A MA054118 A MA 054118A MA 54118 A MA54118 A MA 54118A MA 54118 A MA54118 A MA 54118A
Authority
MA
Morocco
Prior art keywords
therapy
checkpoint inhibitor
adoptive cell
cell therapy
multiple therapy
Prior art date
Application number
MA054118A
Other languages
English (en)
Inventor
Stanley R Frankel
Jens Hasskarl
Oliver Manzke
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MA54118A publication Critical patent/MA54118A/fr

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
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    • A61K31/66Phosphorus compounds
    • A61K31/664Amides of phosphorus acids
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K14/70521CD28, CD152
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K2239/48Blood cells, e.g. leukemia or lymphoma
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MA054118A 2018-01-31 2019-01-31 Polythérapie utilisant une thérapie cellulaire adoptive et un inhibiteur de point de contrôle MA54118A (fr)

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US201862624802P 2018-01-31 2018-01-31

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MA54118A true MA54118A (fr) 2021-09-15

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MA054118A MA54118A (fr) 2018-01-31 2019-01-31 Polythérapie utilisant une thérapie cellulaire adoptive et un inhibiteur de point de contrôle

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US (1) US20210069246A1 (fr)
EP (1) EP3746117A1 (fr)
JP (1) JP7383620B2 (fr)
KR (1) KR20200128014A (fr)
CN (1) CN111971059A (fr)
MA (1) MA54118A (fr)
WO (1) WO2019152743A1 (fr)

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Publication number Priority date Publication date Assignee Title
EP4055383A1 (fr) 2019-11-05 2022-09-14 Juno Therapeutics, Inc. Procédés de détermination d'attributs de compositions de cellules t thérapeutiques
US20230201207A1 (en) * 2020-05-07 2023-06-29 Shanghai Huayu Biotechnology Co., Ltd. Combination cancer therapy using n2-quinoline or isoquinoline substituted purine derivatives
EP4150640A1 (fr) 2020-05-13 2023-03-22 Juno Therapeutics, Inc. Procédés d'identification de caractéristiques associées à une réponse clinique et leurs utilisations
CN112142854B (zh) * 2020-09-18 2021-06-15 南京凯地生物科技有限公司 免疫调节特异性嵌合抗原受体细胞及制备方法和应用
WO2022216815A1 (fr) * 2021-04-08 2022-10-13 Artiva Biotherapeutics, Inc. Traitement du cancer par des cellules nk et un anticorps ciblant le cd20
WO2023230548A1 (fr) 2022-05-25 2023-11-30 Celgene Corporation Procédé de prédiction d'une réponse à une thérapie par lymphocyte t

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