KR20210037093A - Apparatus and method for manufacturing micro-needles and micro-needle manufactured thereby - Google Patents

Abstract

The present invention can provide an apparatus and method for manufacturing a microneedle, and a microneedle manufactured thereby, wherein a core mold is constructed by combining a needle base mold and a plurality of partial needle molds having grooves corresponding to a partial region of a side surface of a microneedle, and thus a microneedle apparatus with a uniform shape and sharp attachment can be rapidly mass-produced at low cost. Also, by variously changing the combination of the partial needle molds, it is possible to manufacture microneedle apparatuses of various lengths, thicknesses and shapes. In addition, in a microneedle apparatus in which a plurality of microneedles are arranged, a structure of a microneedle array may be varied.

Description

A microneedle manufacturing apparatus and method, and a microneedle manufactured by the apparatus TECHNICAL FIELD [Apparatus and method for manufacturing micro-needles and micro-needle manufactured thereby}

The present invention relates to a microneedle manufacturing apparatus and method, and to a microneedle manufactured thereby, and to a microneedle manufacturing apparatus and method using a mold combination, and a microneedle apparatus manufactured thereby.

As existing drugs or cosmetics are used in a form applied to the skin, the drugs or cosmetics reach only the epidermal layer of the skin, and the ingredients do not penetrate into the skin, so the effect is small compared to the amount used. In order to overcome this problem, a micro needle has recently been in the spotlight.

The microneedle uses a number of very small and delicate microneedles of several hundreds of micrometers to several millimeters in length to penetrate the scalp or the inside of the skin, especially the epidermal layer of the skin to deliver drugs or cosmetics to the dermis, thereby improving the absorption rate of drugs or cosmetics. There is an advantage that it can be increased. In other words, it can induce a greater effect with less usage.

For this reason, in the case of cosmetics, it can be expected to improve moisture in the dermis and epidermis, improve gloss, improve skin elasticity, improve skin swelling, improve sagging under the eyes, and alleviate dark circles.If applied to the scalp, it can prevent, manage and improve alopecia It is expected to be able to give you.

In particular, in recent years, research to use microneedles as a means to change the route of administration of drugs without causing pain to the user by replacing oral drugs or infusion drugs has been continued.

On the other hand, conventional microneedles are mainly manufactured by forming intaglio grooves in the core mold by techniques such as high voltage electric discharge in metal, and after combining the manufactured core mold with the fixed mold, a member that is the material of the microneedle is formed in the core mold. It was manufactured by injecting into the groove However, according to the conventional manufacturing method described above, not only are the grooves of the intaglio formed uniformly in the core mold, and the ends of the grooves are formed rounded. In addition, even if the material of the microneedles is injected into the mold, the material does not reach the end of the groove by gas such as air accumulated in the groove. As a result, the microneedles are not formed in a uniform and uniform size, and the microneedles are attached. Is not sharply formed. In addition, if the microneedles are not sharply formed, drugs or cosmetics are difficult to penetrate deep into the skin and cause pain to the user and weaken the effect.

In order to solve the above-described microneedle manufacturing problem, a method of manufacturing microneedles by controlling temperature and pressure in a chamber, or a method of manufacturing microneedles by metal processing and fixing them to a pre-manufactured needle base has been proposed. However, these methods require a high manufacturing cost and have low production efficiency, which increases the cost of the microneedles.

Korean Patent Publication No. 10-2018-0046829 (published on May 9, 2018)

An object of the present invention is to provide a microneedle manufacturing apparatus and method, and a microneedle apparatus manufactured thereby, capable of forming microneedles in a uniform shape with sharp attachments.

Another object of the present invention is to provide a microneedle manufacturing apparatus and method capable of rapidly mass-producing microneedles at low cost, and a microneedle apparatus manufactured thereby.

Another object of the present invention is to provide a microneedle manufacturing apparatus and method capable of easily manufacturing a microneedle array in various lengths, thicknesses, and shapes, and a microneedle apparatus manufactured thereby.

The microneedle manufacturing apparatus according to an embodiment of the present invention for achieving the above object has a size corresponding to the spacing between rows or columns of an array pattern in which a plurality of microneedles are arranged in the microneedle device, A plurality of partial needle molds in which at least one needle groove is formed in a shape corresponding to a part of the side shape of the needle, and a needle base mold in which the arranged plurality of partial mold needles are disposed adjacent to each other in a predetermined order and inserted and fixed therein Including a core mold having a, wherein each of the plurality of partial needle molds form a mold groove corresponding to the shape of the microneedle together with the abutting side surface of the partial needle mold disposed adjacent to the needle groove formed on the side surface.

Each of the plurality of partial needle molds may be formed to have a length corresponding to a length of a corresponding column (or row) of the array pattern and a width corresponding to an interval between columns (or rows).

The at least one needle groove may be formed to have a depth corresponding to a width of the microneedles and a depth corresponding to a length of the microneedles.

The plurality of partial needle molds may form a mold groove corresponding to the shape of the microneedle by combining needle shapes respectively formed at positions corresponding to each other on a side surface of two partial needle molds disposed adjacent to each other.

The microneedle device may further include a needle base in which the plurality of microneedles are formed on one surface to fix the plurality of microneedles.

The needle base mold may have a base mold for forming the needle base together with upper surfaces of the plurality of partial needle molds.

The microneedle manufacturing apparatus may further include a base mold having a structure in which the core mold is inserted and opened and closed in order to fix the core mold when manufacturing the microneedle.

The base mold may include first and second base molds respectively fixing one surface of the core mold and the other surface on which the base mold is formed.

The second base mold may further include a base mold for forming the other surface of the needle base on a contact surface with the core mold.

The microneedle device is formed to accommodate a solution of a predetermined component to be transmitted to the plurality of microneedles on the other surface of the needle base, and a plurality of transmitting the solution to the plurality of microneedles through the needle base therein. It may further include a reservoir in which the transmission pipe is formed.

The microneedle manufacturing apparatus includes a plurality of rods extending to an upper surface of the core mold through a reservoir hole formed through the second base mold to form the reservoir and the plurality of transmission pipes. It may further include a reservoir mold formed of.

A method of manufacturing a microneedle according to another embodiment of the present invention for achieving the above object has a size corresponding to the spacing between rows or columns of an array pattern in which a plurality of microneedles are arranged in a microneedle device, To manufacture a core mold comprising a plurality of partial needle molds in which at least one needle groove is formed in a shape corresponding to a part of the side shape of the needle and at least one needle base mold in which the plurality of partial needle molds are fixed. step; The plurality of partial needle molds are arranged in a predetermined order so as to form a mold groove corresponding to the shape of the microneedle together with the abutting side of the partial needle mold in which the needle grooves formed on each side of the plurality of partial needle molds are disposed adjacently. Placing adjacent to each other; Constructing a core mold by inserting and fixing the plurality of partial needle molds into the needle base mold; And manufacturing the microneedle device by supplying the material of the microneedle to the core mold.

Accordingly, the microneedle manufacturing apparatus and method according to the embodiment of the present invention and the microneedle apparatus manufactured thereby combine a plurality of partial needle molds and needle base molds in which grooves corresponding to the side partial regions of the microneedles are formed. By constructing a mold, a microneedle device having a uniform shape and a sharp attachment can be rapidly mass-produced at low cost. In addition, by variously changing the combination of the partial needle mold, it is possible to manufacture a microneedle device of various lengths, thicknesses, and shapes. In addition, in a microneedle device in which a plurality of microneedles are arranged, the structure arrangement structure of the microneedle array can be variously varied and manufactured.

1 shows the structure of a microneedle manufacturing apparatus according to an embodiment of the present invention.
2 shows an exploded view of the microneedle manufacturing apparatus of FIG. 1.
3 and 4 show a combined view and an exploded view of the core mold of FIG. 2.
5 shows a detailed structure of the partial needle mold of FIG. 4.
6 is a diagram illustrating a structure in which a microneedle array is formed by the partial needle mold of FIG. 5.
7 shows an example of a microneedle apparatus manufactured using the microneedle manufacturing apparatus of this embodiment.
8 shows a method of manufacturing a microneedle according to an embodiment of the present invention.

In order to fully understand the present invention, operational advantages of the present invention, and objects achieved by the implementation of the present invention, reference should be made to the accompanying drawings illustrating preferred embodiments of the present invention and the contents described in the accompanying drawings.

Hereinafter, the present invention will be described in detail by describing a preferred embodiment of the present invention with reference to the accompanying drawings. However, the present invention may be implemented in various different forms, and is not limited to the described embodiments. In addition, in order to clearly describe the present invention, parts irrelevant to the description are omitted, and the same reference numerals in the drawings indicate the same members.

Throughout the specification, when a certain part "includes" a certain component, it means that other components may be further included, rather than excluding other components unless specifically stated to the contrary. In addition, terms such as "... unit", "... group", "module", and "block" described in the specification mean a unit that processes at least one function or operation, which is hardware, software, or hardware. And software.

1 shows a structure of a microneedle manufacturing apparatus according to an embodiment of the present invention, and FIG. 2 shows an exploded view of the microneedle manufacturing apparatus of FIG. 1.

The microneedle manufacturing apparatus according to the present embodiment is described on the assumption that the microneedles are manufactured by injection molding, and in FIGS. 1 and 2, the mold, which is the most important component in the injection molding method, is for convenience of explanation. It is shown based on the structure. However, the microneedle manufacturing apparatus according to the present embodiment may further include additional components required for general injection molding in addition to the configurations shown in FIGS. 1 and 2, which are well known and will not be described in detail here.

Referring to FIGS. 1 and 2, the microneedle manufacturing apparatus according to the present embodiment includes a core mold 200 for forming microneedles and a base mold 100 surrounding the outer edge of the core mold.

The core mold 200 is a core component for forming microneedles in the microneedle manufacturing apparatus of this embodiment. Since the microneedles have a fine size, when individual microneedles are used independently, the amount of drugs or cosmetics that can penetrate into the user's skin using the microneedles is very small. Accordingly, the microneedles are generally not used independently, but are used as a microneedle device in which a plurality of microneedles are arranged in an array form, and a plurality of microneedles devices arranged in an array form are generally referred to as a microneedle for brief. For example, microneedles arranged in an array are mainly implemented and used in the form of devices such as patches and rollers.

Accordingly, in FIGS. 1 and 2, the core mold 200 is shown to be formed to manufacture a microneedle device in which a plurality of microneedles are arranged in an array form. A detailed description of the configuration and structure of the core mold 200 will be described later.

The base mold 100 is a core fixing mold for inserting and fixing the core mold 200 therein. In general, the injection molding apparatus is formed to have a standardized size regardless of the size of the core mold 200 and is manufactured as a general-purpose apparatus capable of manufacturing various various products. Accordingly, the outer shape of the base mold 100 is manufactured according to a predetermined standard, and a cavity corresponding to the shape of the core mold 200 is formed therein so that the core mold 200 is inserted and fixed, so that a general-purpose injection molding apparatus is provided. It allows it to be used as a microneedle manufacturing device. That is, the base mold 100 plays a role of adjusting the difference between the standardized injection molding apparatus and the core mold 200 manufactured in various forms.

1 and 2, the base mold 100 may include a first base mold 110, a second base mold 120, and a third base mold 130.

The first base mold 110 and the second base mold 120 are formed in a structure that is coupled to or separated from each other by a guide rail or a chuck (not shown), and the third base mold 130 and the core It plays the role of fixing the front and back of the mold. In addition, as shown in FIG. 2, the second base mold 120 has a mold and a hole for forming the other surface of the needle base on which a plurality of microneedles are arranged, and supplying the material of the microneedles to the core mold 200. Can be formed.

In the third base mold 130, a cavity corresponding to the side shape of the core mold 200 is formed therein, so that the core mold 200 is inserted and fixed, and the lateral movement of the core mold 200 while manufacturing the microneedle. Prevent this from happening.

Here, as an example, the third base mold 130 is illustrated as being composed of a first base mold 110 and a second base mold 120 and a separate mold. However, in some cases, the third base mold 130 is a first base mold. It may be formed integrally with one of the mold 110 and the second base mold 120. In addition, the third base mold 130 may be divided so that part of the second base mold 110 and the other part of the second base mold 120 may be formed. In addition, a coupling groove or a coupling protrusion for stably coupling the core mold 200 may be further formed in the third base mold 130.

Meanwhile, the second base mold 120 may further include a supply pipe insertion hole into which the supply pipe 400 for supplying the material of the microneedle to the core mold 200 disposed inside the base mold 100 is inserted. .

The supply pipe 400 serves to transfer the molten microneedle material to the core mold disposed inside the base mold 100. In particular, in this embodiment, since it is necessary to accurately form a plurality of microneedles having a small size, a plurality of supply pipes 400 having various sizes may be used.

In the present embodiment, the microneedle device may further include a reservoir for supplying medicines or cosmetics with a plurality of microneedles arranged in an array. Currently, in the case of a patch-type microneedle device, most of the microneedles are coated with a drug or cosmetics applied to the protruding surface, and a protective sheet is attached to prevent evaporation of the coated drug. However, most of the microneedle devices of this structure can be used only for single use, and the amount of drugs that can be used is limited. Therefore, it becomes a factor that makes it difficult for the microneedle device to be used in place of the current syringe. In order to overcome this limitation, the microneedle device according to the present embodiment further includes a reservoir capable of temporarily storing drugs or cosmetics of a certain level, and delivering drugs through the inside of the needle base inside the reservoir. A plurality of transmission pipes are formed to allow a uniform amount of chemicals to be delivered to a plurality of microneedles arranged in an array.

Accordingly, the microneedle manufacturing apparatus according to the present embodiment may further include a reservoir mold 300 in order to integrally form a reservoir with the microneedle. The reservoir mold 300 has a structure in which a plurality of rods for forming a plurality of transmission pipes are formed, penetrates through the reservoir hole formed in the second base mold 120, and is inserted and fixed to one surface of the core mold 200. 2 A reservoir is formed together with the reservoir hole of the base mold 120. In addition, the reservoir mold 300 may play a role of transferring the molten material supplied from the plurality of supply pipes 400 to the core mold 200 at a possible uniform pressure.

However, the reservoir mold 300 is a configuration used when a reservoir is formed in the microneedle device, and may be omitted when the reservoir is not included, such as when the microneedle device is implemented in a patch type.

3 and 4 show an exploded view and a combined view of the assembly-type combination mold of FIG. 2, FIG. 5 shows a detailed structure of the partial needle mold of FIG. 4, and FIG. 6 is a microneedle array by the partial needle mold of FIG. It is a diagram for explaining the structure to be formed. And Fig. 7 shows an example of a microneedle device manufactured using the microneedle manufacturing device of this embodiment.

3 and 4, the core mold 200 is a needle base 510 in which a plurality of partial needle molds 220 for forming a plurality of micro needles 520 and a plurality of micro needles 520 are disposed. And at least one needle base mold 210 for fixing the combined plurality of partial needle molds 220.

As shown in FIG. 5, in each of the plurality of partial needle molds 220, at least one needle groove 222 corresponding to the longitudinal shape of the microneedle 520 is formed, and a plurality of partial needle molds 220 ) Are arranged and fixed adjacent to each other at a predetermined position inside the needle base mold 210. In this case, the plurality of partial needle molds 220 may be formed and disposed in a structure corresponding to the arrangement of the plurality of microneedles 520 provided in the microneedle device 500 to be manufactured. As an example, in FIG. 6, each of the plurality of partial needle molds 220 has a width and a needle base mold corresponding to the length in the column (or row) direction of the array in which the plurality of micro needles 520 are arranged and the spacing between the columns (or rows). It may be formed in a shape having a height corresponding to the thickness of 210. That is, a plurality of microneedles 520 may be formed and combined in a shape corresponding to a row or column structure of an array.

Here, the needle groove 222 of the partial needle mold 220 may be formed by a profile processing method, for example.

5 and 6, in the partial needle mold 220 that is adjacent to each other and coupled to each other, the needle grooves 222 are formed at positions corresponding to each other, so that the two adjacent partial needle molds 220 are arranged in one row ( Or a row) of microneedles 520 to form. Therefore, it is shown that the plurality of partial needle molds 220 have a length in the column (or row) direction and a width corresponding to the distance between columns (or rows), but in some cases, the plurality of partial needle molds 220 are spaced between rows. It may be formed to have a length corresponding to a and a width corresponding to the spacing between columns. That is, a plurality of microneedles 520 may be formed and combined in a shape corresponding to the row and column structure of an array.

In addition, in FIG. 4, the partial needle mold 220 disposed in both directions from the partial needle mold 220 disposed in the center among the plurality of partial needle mold 220 is formed to have a relatively shorter length. This is because in the microneedle device 500 of the present embodiment, it is assumed that a plurality of microneedles 520 are arranged in a circular array. If the plurality of microneedles 520 are arranged in a square array, a plurality of parts All of the needle mold 220 may be formed to have the same length.

And in Figure 4, the width of the partial needle mold 220 disposed at both ends of the plurality of partial needle molds 220 is formed relatively narrower than the remaining partial needle mold 220, which is a portion disposed at both ends. This is because in the case of the needle mold 220, the needle groove 222 is formed only on one side.

Meanwhile, the needle groove 222 formed in each of the plurality of partial needle molds 220 is formed in a shape corresponding to a part of the side of each of the plurality of microneedles 520, and in FIG. 4, as an example, the needle groove 222 is formed in a shape corresponding to the side half. It is assumed that it is formed.

In this case, unlike the conventional core mold in which grooves have to be formed with a depth and width corresponding to the length and width of the microneedle to form the microneedles, in this embodiment, corresponding to half the width of the microneedle 520 Since the needle groove 222 is formed to the depth and the length of the needle groove 222 is formed to correspond to the depth of the microneedle, the needle groove 222 can be very easily formed in a plurality of partial needle molds 220. have.

In addition, it was difficult to freely control the width and length of the microneedle, as the core mold was manufactured by forming a groove by the electric discharge machining method in the past, and the shape of the microneedle was also limited to a cylinder or conical shape. There was a limit to being difficult to form.

In contrast, in this embodiment, the core mold 200 is composed of a plurality of partial needle molds 220 in which needle grooves 222 corresponding to the longitudinal shape of the microneedle 520 are formed. Therefore, by processing the needle groove 222 into various shapes, the microneedle 520 can be formed in various shapes such as a triangular pillar, a triangular horn, a square pillar, a square horn, etc. in addition to a cylinder or a cone shape.

In addition, since the two partial needle molds 220 disposed adjacent to each other are combined to form a groove for forming the microneedle 520, when the material of the microneedle device 500 is injected, it is accumulated in the formed groove. Gases such as air may be discharged through the bonding interface between the two partial needle molds 220. Therefore, without using equipment such as a chamber for controlling temperature and pressure, the attachment of the microneedle 520 can be manufactured very sharply as shown in FIG. 7 even at the temperature and pressure in a conventional injection molding method. In other words, it is easy to manufacture at low cost and at high speed, while making it possible to manufacture microneedles that are much sharper than conventional microneedles.

In FIGS. 5 and 6, assuming that the microneedle 520 is formed in a conical shape, at least one needle groove at a position corresponding to each other on a surface facing each other in two partial needle molds 220 disposed adjacent to each other. (222) was formed. However, as described above, if the microneedle 520 is formed in a shape such as a triangular pillar, a triangular horn, a square pillar, and a square horn, only one of the two partial needle molds 220 disposed adjacent to each other is a needle groove ( 222) may be formed. That is, the needle groove 222 may be formed only on one side of each of the plurality of partial needle molds 220 rather than both sides.

In addition, a coupling protrusion 221 or a coupling groove for stably coupling and fixing a plurality of partial needle molds 220 to at least one needle base mold 210 is further formed at one end or the other end of the plurality of partial needle molds 220 Can be.

Meanwhile, at least one needle base mold 210 has an external shape corresponding to the shape of a cavity formed in the third base mold 130, and a base coupling protrusion on the outside so as to be stably coupled and fixed with the third base mold 130 ( 211) or the base coupling groove 212 may be formed.

In addition, a plurality of partial needle molds 220 may be stably arranged and fixed on the inner surface of at least one needle base mold 210, and may be formed in a shape corresponding to the outer surface of the combined plurality of partial needle molds 220. have. As an example, in FIG. 4, in response to a structure in which a plurality of partial needle molds 220 of different lengths are coupled, the inner needle mold coupling surface 214 is formed in a multi-stage structure.

In particular, in this embodiment, a base mold 213 is formed on the upper surface of the at least one needle base mold 210 so that the needle base 510 of the microneedle device 500 can be formed. The base mold 213 forms one surface of the needle base 510 in the direction in which the plurality of needles 520 are arranged in the microneedle device 500 together with the upper surfaces of the combined plurality of partial needle molds 220. That is, the base mold formed in the second base mold 120 to form the other surface of the needle base 510, the base mold 213 of the needle base mold 210, and a plurality of combined partial needle molds 220 are combined. The needle base 510 can be formed.

Meanwhile, referring to FIG. 7, a reservoir 530 for storing drugs or cosmetics may be further formed in the microneedle device 500, and a direction in which a plurality of needles 520 are arranged from the inside of the reservoir 530 A plurality of transmission pipes 540 may be formed so that a uniform amount of medicine or cosmetics is delivered to a plurality of microneedles 520 up to one surface of the needle base 510 of the. Drugs or cosmetics delivered from the reservoir 530 to one surface of the needle base 510 through the plurality of transmission pipes 540 are supplied to the surface of the plurality of microneedles 520 along one surface of the needle base 510 . In addition, drugs or cosmetics supplied to the surface of the plurality of microneedles 520 may be delivered to the inside of the dermis layer when the plurality of microneedles 520 pass through the user's skin epidermal layer and reach the dermis layer.

8 shows a method of manufacturing a microneedle according to an embodiment of the present invention.

Referring to FIGS. 1 to 7, the method of manufacturing the microneedle of FIG. 8 will be described, first, shapes of a plurality of microneedles 520 to be manufactured are determined (S11). As described above, in the conventional microneedle manufacturing method, not only the shape of the microneedle is limited to a shape such as a cylinder or a cone, but it is difficult to freely control the size such as depth or width, while manufacturing the microneedle according to the present embodiment. When using the device, microneedles of various sizes and shapes can be manufactured according to the shape of the needle grooves 222 formed in the plurality of partial needle molds 220 of the core mold 200. Accordingly, the shape of the microneedle 520 may be determined in consideration of the optimal size and shape in consideration of the intended use of the microneedle device. Here, the shape of the microneedle 520 may be determined by being input to the microneedle manufacturing apparatus in the form of a user command.

When the shape of the microneedles 520 is determined, an array pattern in which a plurality of microneedles are disposed is determined (S12). As described above, in the case of the microneedle 520 having a fine structure, a plurality of microneedles 520 are generally arranged in an array pattern and used as a microneedle device. And as shown in FIGS. 4 to 7, in the present embodiment, two partial needle molds 220 disposed adjacent to each other among a plurality of partial needle molds 220 are microneedles in one column (or row). Since a mold groove for manufacturing 520 can be formed, the shape and manufacturing process of the plurality of partial needle molds 220 change according to the array pattern. Accordingly, the array pattern of the microneedles has a great effect on the reduction of manufacturing cost, and thus the array pattern in which the plurality of microneedles 520 are to be disposed may be determined in consideration of the use purpose and manufacturing convenience of the microneedle device.

In this case, the overall structure of the microneedle device, that is, the shape of the needle base 510 may be determined together with the array pattern of the microneedle 520. In addition, whether the reservoir 530 is added and the size and shape of the reservoir may be determined together. When it is determined that the reservoir 530 is added, the number, position, and width of the transmission pipe 540 may also be determined. . That is, the overall structure of the microneedle device can be determined.

Here, the array pattern and the shape of the needle base 510 may also be determined by being input to the microneedle manufacturing apparatus in the form of a user command.

When the structure of the microneedle device is determined, the structure of the core mold 200 is determined according to the determined structure of the microneedle device (S13). As described above, in the microneedle manufacturing apparatus according to the present embodiment, the core mold 200 includes a plurality of partial needle molds 220 and at least one needle base mold 210.

Therefore, in the core mold 200, first, the number and size of the partial needle molds 220 and the position to form the needle groove 222 are determined according to the array pattern of the microneedle 520, and the shape of the microneedle 520 Accordingly, the length, depth, and shape of the needle groove 222 in the plurality of partial needle molds 220 are determined. Further, the shape of the inner surface of the needle base mold 210 is determined based on the shape of the outer surface in a state in which the plurality of partial needle molds 220 are coupled to determine the structure of the core mold.

When the structure of the core mold is determined, the core mold is processed according to the structure (S14). During core mold processing, the outer shape of the plurality of partial needle molds 220 is processed to have a length, width, and height determined according to the array pattern of the microneedle 520, and then, the needle groove 222 is determined in length, depth, and Depending on the shape, each of the plurality of partial needle molds 220 is formed on a side surface in contact with the partial needle molds disposed adjacent to each other. At this time, the needle groove 222 may be formed on each side of the two partial needle molds 220 disposed adjacent to each other according to the shape of the microneedle 520, but one partial needle mold 220 It may be formed only on the side. For example, when the microneedle 520 is a cylindrical or conical shape, a needle groove 222 must be formed in each of the two partial needle molds 220, but the microneedles 520 are located on one side, such as a triangular column or a square column. In the case of a shape having a flat surface, the needle groove 222 may be formed only on the side surface of one partial needle mold 220.

In addition, at least one needle base mold 210 is processed together with a plurality of partial needle molds 220 according to the determined structure of the core mold 200. In addition, the third base mold 130 of the base mold 100 may be processed according to the outer shape of the core mold 200, and the second base mold 130 may be processed based on the shape of the needle base 510 of the microneedle device 500. The base mold 120 can be processed. In addition, when the reservoir 530 is included in the microneedle device 500, the reservoir mold 300 may be processed together with the core mold 200, and the reservoir mold 300 is included in the second base mold 120. A hole into which) can be inserted may be further formed.

When a plurality of partial needle molds 220 with needle grooves and at least one needle base mold 210 are processed, the processed plurality of partial needle molds 220 and at least one needle base mold 210 are combined to form a core. Obtain a mold (S15). Then, the obtained core mold 200 is combined with the previously manufactured base mold 100 (S16).

Thereafter, the microneedle device 500 is manufactured by injection molding using the base mold 100 to which the core mold 200 is coupled (S17). In addition, when the microneedle device 500 is injected, post-treatment operations such as cooling and surface treatment may be added (S18).

The method according to the present invention can be implemented as a computer program stored in a medium for execution on a computer. Here, the computer-readable medium may be any available medium that can be accessed by a computer, and may also include all computer storage media. Computer storage media includes both volatile and nonvolatile, removable and non-removable media implemented in any method or technology for storage of information such as computer readable instructions, data structures, program modules or other data, and ROM (Read Dedicated memory), RAM (random access memory), CD (compact disk)-ROM, DVD (digital video disk)-ROM, magnetic tape, floppy disk, optical data storage device, and the like.

The present invention has been described with reference to the embodiments shown in the drawings, but these are merely exemplary, and those of ordinary skill in the art will understand that various modifications and equivalent other embodiments are possible therefrom.

Therefore, the true technical protection scope of the present invention should be determined by the technical spirit of the appended claims.

100: base mold 110: first base mold
120: second base mold 130: third base mold
200: core mold 210: needle base mold
220: partial needle mold 222: needle groove
300: reservoir mold 400: supply pipe
500: microneedle device 510: needle base
520: micro needle 530: reservoir
540: transmission tube

Claims (17)

In the microneedle device, at least one needle groove is formed in a shape corresponding to a spacing between rows or columns of an array pattern in which a plurality of microneedles are arranged, and each at least one side has a shape corresponding to a part of the side shape of the microneedle. A plurality of partial needle molds; And
A core mold having a needle base mold in which the arranged plurality of partial mold needles are disposed adjacent to each other in a predetermined order and inserted and fixed therein,
Each of the plurality of partial needle molds forms a mold groove corresponding to the shape of the microneedle together with the abutting side of the partial needle mold in which the needle grooves formed on the side surfaces are disposed adjacent to each other. The method of claim 1, wherein each of the plurality of partial needle molds
A microneedle manufacturing apparatus formed to have a length corresponding to a length of a corresponding column (or row) of the array pattern and a width corresponding to an interval between the columns (or rows). The method of claim 1, wherein the at least one needle groove
Microneedle manufacturing apparatus formed to have a depth corresponding to the width of the microneedles and a depth corresponding to the length of the microneedles. The method of claim 1, wherein the plurality of partial needle molds
A microneedle manufacturing apparatus for forming a mold groove corresponding to the shape of the microneedles by combining needle shapes respectively formed at positions corresponding to each other on a side surface of two partial needle molds disposed adjacent to each other. The method of claim 1, wherein the microneedle device
The plurality of microneedles are formed on one surface further comprising a needle base fixing the plurality of microneedles,
The needle base mold
A microneedle manufacturing apparatus in which a base mold for forming the needle base is formed together with an upper surface of the plurality of partial needle molds. The method of claim 5, wherein the microneedle manufacturing apparatus
In order to fix the core mold during manufacturing of the microneedle, the microneedle manufacturing apparatus further comprises a base mold having a structure in which the core mold is inserted and opened and closed. The method of claim 6, wherein the base mold
Microneedle manufacturing apparatus comprising first and second base molds respectively fixing one surface of the core mold and the other surface on which the base mold is formed. The method of claim 7, wherein the second base mold
A microneedle manufacturing apparatus in which a base mold for forming the other surface of the needle base is further formed on a contact surface with the core mold. The method of claim 7, wherein the microneedle device
The other surface of the needle base is formed to accommodate a solution of a predetermined component to be transferred to the plurality of microneedles, and a plurality of transmission pipes are formed to pass through the needle base to transfer the solution to the plurality of microneedles. Including more reservoirs,
The microneedle manufacturing apparatus
A reservoir mold formed in a structure including a plurality of rods extending to an upper surface of the core mold through a reservoir hole formed through the second base mold to form the reservoir and the plurality of transmission pipes Microneedle manufacturing apparatus further comprising a. In the microneedle device, at least one needle groove is formed in a shape corresponding to a spacing between rows or columns of an array pattern in which a plurality of microneedles are arranged, and each at least one side has a shape corresponding to a part of the side shape of the microneedles. Manufacturing a core mold including a plurality of partial needle molds and at least one needle base mold having the plurality of partial needle molds fixed therein;
The plurality of partial needle molds are arranged in a predetermined order so as to form a mold groove corresponding to the shape of the microneedle together with the abutting side of the partial needle mold in which the needle grooves formed on each side of the plurality of partial needle molds are disposed adjacent to each other. Placing adjacent to each other;
Constructing a core mold by inserting and fixing the plurality of partial needle molds into the needle base mold; And
And manufacturing the microneedle device by supplying the material of the microneedle to the core mold. The method of claim 10, wherein the step of manufacturing the core mold
Forming each of the plurality of partial needle molds to have a length corresponding to a length of a corresponding column (or row) of the array pattern and a width corresponding to an interval between the columns (or rows); And
Forming a needle groove in each of the plurality of partial needle molds to have a depth corresponding to the width of the microneedles and a depth corresponding to the length of the microneedles; And
Forming the needle base mold to have an inner shape corresponding to a side shape of a plurality of partial needle molds disposed adjacent to each other. The method of claim 10, wherein the adjacently disposing step
A microneedle arranged to form a mold groove corresponding to the shape of the microneedle by combining the shapes of needles respectively formed at positions corresponding to each other on the side surfaces of the two partial needle molds disposed adjacent to each other among the plurality of partial needle molds Manufacturing method. The method of claim 10, wherein the microneedle device
The plurality of microneedles are formed on one surface further comprising a needle base fixing the plurality of microneedles,
The step of manufacturing the core mold
The method of manufacturing a microneedle further comprising forming a base mold for forming the needle base together with upper surfaces of the plurality of partial needle molds on the needle base mold. The method of claim 13, wherein the microneedle manufacturing method
In the step of manufacturing the microneedle device, further comprising forming a base mold having a structure in which the core mold is inserted and opened and closed so that the core mold is fixed,
The step of forming the base mold
Forming a first base mold fixing one surface of the core mold; And
Forming a second base mold fixing the other surface of the core mold on which the base mold is formed. The method of claim 14, wherein forming the base mold
The method of manufacturing a microneedle further comprising forming a base mold for forming the other surface of the needle base on a contact surface of the second base mold with the core mold. The method of claim 14, wherein the microneedle device
The other surface of the needle base is formed to accommodate a solution of a predetermined component to be transferred to the plurality of microneedles, and a plurality of transmission pipes are formed to pass through the needle base to transfer the solution to the plurality of microneedles. Including more reservoirs,
The microneedle manufacturing method
Forming a reservoir hole penetrating the second base mold to form the reservoir and the plurality of transmission pipes;
Manufacturing a reservoir mold formed in a structure including a plurality of rods extending to an upper surface of the core mold through the reservoir hole; Microneedle manufacturing method further comprising. A microneedle device manufactured by the method of manufacturing a microneedle according to any one of claims 10 to 16.

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