KR20150108804A - Safety neural injection system and related methods - Google Patents

Abstract

Provided in various embodiments of the present invention are a safety neural injection system including a first inner diameter, a first outer diameter, a first length, and an opened distal end connected to the inner and outer sides of a hollow cannula for a fluid, and including a cannlar and a probe part including or not including a side port, and a method for using the same. The drug is at least partially injected by the probe part inserted into the inside of the cannula.

Description

[0001] The present invention relates to a safety neural injection system and related methods,

The present invention relates to a safety nerve injection system and related methods using the same.

Needle and needle systems are widely used in a wide range of therapeutic applications in various medical fields such as cardiac surgery, radiology, urology, interventional pain management, and internal medicine. The use of needle and needle systems in invasive procedures in a variety of medical disciplines has become universal due in part to the ability of the needle to pass through most tissues without causing serious damage to the tissue.

A common needle has an orifice or port at the distal end of the needle. The distal tip of the needle is prone to clogging because the tip of the needle is used to penetrate the tissue to access the treatment site. In addition, when a general needle is used, there is a high possibility that an agent to be injected is leaked.

Another widely used type of needle system is a system employing a catheter and guide member. Such a needle system includes a small guide member (e.g., a guide wire) that is used to guide a large hollow catheter to a target area (e.g., a container, a body cavity, a tissue or an organ) within the body of the human or animal . These needle systems are effective for treatment and diagnosis.

It is desirable to reduce the risk of internal damage from sharp blades or edges of conventional infusion systems, or by providing a tip that is not smooth, round or flat, but not sharpened. The leading edge is made of a material that bends when it meets a dense surface.

Various embodiments include an at least partially hollow hollow cannula formed by a first inner diameter, a first outer diameter, a first length, and an open distal end in fluid communication with the inner and outer sides of the hollow cannula, A side port positioned coaxially along the hollow cannula in fluid communication between the inner and outer sides, and a probe having a flexible tip with a shaped tip, wherein the flexible nail injection system comprises: The probe having a hollow cannula can be fastened in a first position within the hollow cannula and extends by at least a first length of the hollow cannula; The hollow cannula adjacent the distal end includes a rigid curvature to facilitate proper placement of the distal end in the target area. A further embodiment is characterized by preferentially arranging the shaped tip of the probe with flexibility at the same height position relative to the open distal end of the hollow cannula. Additional embodiments include side ports. In further various embodiments, the probe can be retracted. Additional embodiments include a kit comprising a safety nerve injection system as described herein and an agent to be injected.

Additional embodiments include positioning a target region for treatment against the human body; Adjusting the safety nerve infusion system described above; The system being positioned relative to the human body in a position and orientation plane; Inserting at least a portion of the safety nerve injection system into a target area; Manipulating the safety nerve injection system within the body using a rigid bend adjacent to the distal end to facilitate the proper placement of the safety nerve injection system in the target area; It includes the treatment of the human body, and the treatment of the human body that needs help.

Additional embodiments include: means for locating a target region for processing a human body that requires assistance; Adjusting means for adjusting the safety nerve infusion system described above to cause the system to be positioned relative to the human body in a position and orientation; A means for inserting at least a portion of the safety nerve injection system described above into the human body wherein the hollow cannula of the safety nerve injection system described above is located adjacent to the distal end, Means for manipulating the distal portion of the safety nerve injection system within the body adjacent to the target region, and means for treating the human body, including a rigid bend for facilitation. An optional embodiment of the present invention is directed to a hollow cannula having a first inner diameter, a first outer diameter, a first length, an at least partially hollow hollow cannula formed by a proximal portion in fluid communication with the inside and outside of the hollow cannula; A side port disposed coaxially along the hollow cannula and in fluid communication between the inside and outside of the hollow cannula; Wherein the flexible probing portion is releasably fastened in a first position within the hollow cannula and wherein the flexible cannula has a flexible tip with a shaped tip, Wherein the hollow cannula adjacent the distal end includes a rigid curved portion for locating the proximal portion in the target area and wherein the probe and hollow cannula form at least one channel.

In a further embodiment, the safety nerve injection system further comprises at least one of a connector, a wire, an insulator and a probe.

In one embodiment of the safety nerve injection system comprising a wire, the wire is adapted to be connected to a connector having a meter. In one embodiment of the safety nerve injection system including the connector, the connector may be a plug and a use connector.

With respect to the position of the probe with flexibility, in a particular embodiment of the invention, the first position is characterized by the same height of the shaped tip of the probe which is flexible with respect to the open distal end of the hollow cannula . In another specific embodiment, the first position is characterized in that the shaped tip of the probe with flexibility is protruded beyond the first length.

In the probe portion, according to another embodiment, the probe portion itself further includes a side port. In a further embodiment of the invention, the probe portion can be contracted.

A further embodiment of the invention contemplates that the agent is delivered via the side port attached to the cannula. In such embodiments, the agent may be any agent. In certain embodiments, the agent can be selected from the group comprising a therapeutic agent, a diagnostic agent or an anti-disease agent. In certain embodiments, the therapeutic agent may be a therapeutic narcotic agent.

In another alternative embodiment of the present invention, the side port is not present within the cannula and is not engaged with the probe within the canula such that the drug will flow out of the distal portion in the target area between the probe and the cannula .

In another embodiment of the present invention, there is no channel and no probes and connections within the cannula, allowing the drug to flow from the distal end in the target area between the probe and the cannula.

Another embodiment of the present invention is directed to a method of injecting a drug into a neural tissue, the method comprising: positioning a target region for drug administration; Adjusting the safety nerve injection system to position the system relative to the target area; Injecting at least a portion of the safety nerve injection system into a target area; Manipulating the safety nerve injection system using a rigid bend adjacent to the distal end to facilitate proper placement of the safety nerve injection system in the target area, and administering an agent to the target area.

In certain embodiments of the foregoing methods, the target is an area selected from the group consisting of digestive, circulatory, neural, muscular, skeletal, respiratory, urinary, reproductive, excretory, endocrine, and immune systems of the human body.

In another embodiment of the present invention, the agent is selected from the group consisting of a therapeutic agent, a diagnostic agent, an anti-disease agent. In particular, the agent may be a therapeutic agent and the agent may be an anesthetic agent. In another embodiment of the present invention, the agent may be a biopsy needle. In another embodiment of the invention, the agent is used to stimulate tissue against the target area. In this embodiment, stimulating the tissue involves removing at least a portion of the tissue.

In an additional method of injecting a drug in neural tissue, the method includes manipulating the distal end of the injection system using a real-time imaging device. In this feature, by operating the real-time imaging device, the user can determine the precise location of the distal end in the target area.

In a further embodiment of the method of injecting a drug into a neural tissue, the target region is selected from the group comprising the digestive, circulatory, neural, muscular, skeletal, respiratory, urinary, reproductive, excretory, endocrine and immune systems of the body Area. In this embodiment, administering the agent is done with a probe that extends through the cannula. The probe serves as a safety measuring part while injecting the cannula into the specific part. In one embodiment, the connection between the probe and the cannula causes the drug to pass between the cannula and the probe.

Another embodiment of the present invention includes a kit of the safety nerve injection system described above.

Although the present invention has been described in terms of several embodiments, various changes and modifications may be suggested to one of ordinary skill in the art. In particular, although the present invention has been described on the basis of any polymer and material, and a method of treating such material has been described, it can also be applied to other types of processes and materials with small variations and similar results. In addition, the present invention can take into account a plurality of processing steps which are performed sequentially in a selective order within the scope of the present invention. It is intended that the present invention cover the modifications and variations of this invention provided they come within the scope of the appended claims and their scope.

According to the present invention, a safety nerve infusion system can be provided.

1 is an exploded perspective view of one embodiment of a safety nerve injection system.
Figure 2 is an assembled perspective view of one embodiment of a safety nerve injection system.
Figures 3A-3E illustrate one embodiment of a distal tip of a hollow cannula connected to a shaped tip of a probe having flexibility.
Figure 4 is an exploded perspective view of an alternative embodiment of a safety nerve injection system.
Figure 5 illustrates one embodiment of a neuroinjection system with a cannula.
6 is an assembly view of an alternative embodiment of a neural injection system having an optional cannula and an optionally coupled probe.

A. Preface

The present invention relates to an injection system comprising an inner bore and a hollow cannula having a proximal end and a proximal end, wherein the distal end is inserted at the point of interest, and the flexible probe with the shaped tip comprises an inner bore of the hollow cannula, As shown in FIG. The present invention further includes a gas or fluid reservoir in fluid communication with the hollow cannula.

In one embodiment of the present invention, a cannula having a reservoir attached to a cannula hub is provided, wherein the gas or fluid therapy agent is introduced into the cannula along a hollow bore of the cannula having a probe inserted into the hollow bore through the coupling hub, And stored. In a second embodiment of the present invention, the reservoir is attached to a hub of a cannula having a probe having a hollow bore inserted through a hollow bore of the canula, wherein the probe is permanently attached to the cannula hub. In this embodiment, the reservoir is preferably in fluid communication with the cannula hub. In this embodiment, as an optional example for a gas or fluid treatment reservoir, it can be considered helpful in aspirating a liquid or molecular material from a target position having a distal end of a cannula inserted into a cavity at the target position.

In various embodiments of the present invention, the reservoir is fluidly coupled to the cannula hub such that fluid therapy, such as a liquid medicament, is introduced into the hollow cannula at a desired time after inserting the distal end of the cannula into the target position. These movements are controlled through the plunger of the syringe, the pressure applied to the reservoir by the physician's damage, the pressure applied to the reservoir by the hydraulic pump mechanism, or the piston type pump mechanism. This movement may in this case be controlled by gravity, which is the i.v. It can be a bag.

Various embodiments provide a safe infusion and treatment system and associated method with increased operating efficiency, reduced unit cost, reduced damage through intranasal injection or intravascular injection, reduced damage through swelling or perforation, etc. Lt; / RTI >

Various embodiments include a safety infusion system that includes a cannula that is at least partially hollow. The cannula is formed by a first inner diameter, a first outer diameter, a first length, a side port coaxially disposed along the cannula for fluid communication between the inside and the outside of the hollow cannula, and an open distal end. The system includes a probe having a flexible tip with a shaped tip wherein the probe having flexibility is releasably fastened in a first position within the hollow cannula and extends by at least a first length of the hollow cannula do. The hollow cannula facilitates proper positioning of the proximal portion adjacent the target region during system administration adjacent the distal portion including the rigid curvature.

Various embodiments include methods and apparatus designed to infuse small amounts of therapeutic or diagnostic agents or prophylactic agents that are fluid to the walls of a tissue or body, e. G., An inner body wall. In addition, the target region is disposed in an area or an organ disposed in the human body. The digestive system, circulatory system, nervous system, muscle system, skeletal system, respiratory system, urinary system, reproductive system, excretory system, endocrine system and immune system of the human body are shown through the present invention . The amount of the agent to be administered according to the method of the present invention may be varied depending on the objective to be achieved, the age of the patient, the pharmacokinetics of the drug to be injected, and the like.

Various embodiments are designed for treatment of a target area. In one embodiment, the treatment of the tissue can be at least one of probing, ablation, stimulating, and the like. Generally, in various embodiments, possible treatments can be any common treatment, and are not limited by the present application.

The principles and advantages of the present invention can be understood with reference to FIGS. 1 and 2, wherein like numerals are used for corresponding parts in the various figures.

B. Definitions

The definitions and explanations below are meant to be intended to be controlled in a future configuration when they are not explicitly and explicitly modified in the examples below, or when the application of a meaning is meaningless or basically meaningless. If the composition of the term becomes meaningless or meaningless, its definition can be taken from Webster's Third Edition.

"Attached" and its use means that the two members are at least partially connected.

The term "drug" refers to all fluidic substance types that are beneficial and have the desired or therapeutic effect. Non-limiting examples of drugs suitable for use in the invention of the present invention include small molecule drugs, substances of protein component, polynucleotides or nucleosides (e.g., heteroduplex, RNA), vectors, liposomes, Or polynucleotides as well as anesthetics, biologically active agents such as their constituents or liquid substances.

A "medical device" is an article, apparatus, structure, or article of manufacture that can be connected to a catheter, but not limited to, a catheter, such as a stimulator, a tube, a pipe, a drug delivery system, a meter, a liquid reservoir (e.g., IV bag) Lt; / RTI >

The term "general insertion procedure ", by Hebner et al., 2003. World Pain Institute, Pain Management Practice, Comparative Study of Penetration of Internal Structures and Transfusion Treatments in Sharp Needles and Needles: 3, pp. 226-231. ≪ / RTI >

The term "probe" is about something like a small dagger. The probe of the present invention may be but is not necessarily the.

All numbers expressing quantities of ingredients or reaction conditions used herein may be understood by the term "about " as used herein, unless the context indicates otherwise, for example, or otherwise.

C. Therapeutic  use

In certain embodiments of the invention, it is desirable to deliver the therapeutic agent to the subject through a hollow cannula. Any agent that is injected through the needle can be delivered using the method of the present invention. Typical agents include saline solutions, drugs, small molecules, pharmacological agents, diagnostic agents, biological molecules, proteins, peptides, antibodies, polynucleotides, RNA, DNA, viruses, cells and complexes thereof. Agents can have sizes ranging from small organ molecules to large molecules such as DNA so as not to damage the cells. Agents delivered to the point of infusion may be formulated with therapeutic agents (e. G., Chemotherapeutic agents, antibodies), prophylactic agents (e. G., Vaccines), or diagnostic agents (e. Lt; / RTI >

In another embodiment of the present invention, the hollow cannula and probe may include, for example, a paracentesis, a thoracentesis, an image through a camera attached to a portion of the distal end of the probe, A surgical stimulation technique such as a laser or other incision instrument, an electrical stimulator at the distal end of the probe, an instrument used to remove tissue or liquid from the object, or to transmit light from the light emission mechanism at the distal end of the probe, Is used to remove tissue or liquid from the object using a dye transfer or diagnostic system for diagnostic purposes.

Various embodiments include methods of using the safety nerve injection system. One embodiment of the method comprises the steps of: locating a region for treating a patient; A first end, a first end, a first end, a first end, a first end, a first end, a first end, a first end, a side port disposed coaxially along the hollow cannula to fluidly communicate between the inside and the outside of the hollow cannula, Implanting at least a portion of a safety nerve injection system comprising an at least partially hollow hollow cannula formed by a probe having a first portion in a hollow cannula, And the hollow cannula adjacent to the distal end includes a rigid curve to facilitate proper placement of the prosthesis in the treatment area, and wherein adjacent to the area Manipulating the distal portion of the safety nerve injection system within the patient, and treating the patient.

An additional method embodiment comprises stimulating tissue. An additional method embodiment includes removing at least a portion of the tissue with respect to the area. Another example of a failure involves checking the tissue. An additional method embodiment comprises preparing the patient to administer the drug.

In an embodiment where a block such as a nerve block is administered, the method comprises preparing the patient. In one embodiment, the step of preparing the patient is to place the patient in a neutral or supine position without a pillow and with the head in a neutral position.

In the embodiment of administering the drug, while standing on the side of the body to be blocked, the clinician sets the position of the annular cartilage with the tactile sense. In this embodiment, the nerve infusion system is inserted between the airway and the carotid sheath on one side of the occlusion at a location approximately one finger width below the annular cartilage, and slightly inwardly directed to the bone contact is the seventh cervical vertebra As shown in Fig. Anesthetics are injected when the nerve injection system is in this position.

In another embodiment, a method of injecting a drug into a tissue of a subject is provided. Such methods include injecting the distal portion of this embodiment into the tissue of the subject and allowing the therapeutic agent to enter the tissue in multiple directions from the distal portion. In various embodiments, the probe is inserted through the cannula to act as a buffer to protect the patient's tissue. In various embodiments, the tissue is a neural tissue. However, various embodiments of the present invention may be used in any tissue.

In various embodiments, the inserted probe remains in the cannula, and the drug is inserted into the target tissue or inserted around the inserted probe. In this embodiment, a channel is formed in the canula to provide a passage for the drug. In various embodiments, the connection between the probe and the cannula is connected so that the drug passes through the distal opening of the cannula and against the probe.

D. Medical Equipment

Examples of exemplary, non-limiting medical devices, infusion systems, and the like that can be modified in accordance with various teachings include but are not limited to those described in U.S. Patent Nos. 6,949,087, 6,855,132, 6,558,353, 6,547,769 number; U.S. Patent No. 6,387,163; U.S. Patent No. 6,245,044; U.S. Patent No. 5,871,470; U.S. Patent No. 5,865,806; U.S. Patent No. 5,836,914; U.S. Patent No. 5,817,074; U.S. Patent No. 5,800,445; U.S. Patent No. 5,730,749; U.S. Patent No. 5,669,882; U.S. Patent No. 5,628,734; U.S. Patent No. 5,573,519; U.S. Patent No. 5,571,091; U.S. Patent No. 5,480,389; U.S. Patent No. 5,466,225; U.S. Patent No. 5,336,191; U.S. Patent No. 5,312,360; U.S. Patent No. 5,304,141; U.S. Patent No. 5,250,035; U.S. Patent No. 5,242,410; U.S. Patent No. 5,106,376; U.S. Pat. No. 4,994,034; U.S. Patent No. 4,973,313; U.S. Patent No. 4,629,450; U.S. Patent No. 4,317,445; U.S. Patent No. 4,308,875; U.S. Patent No. 4,230,123; U.S. Patent No. 3,856,009; U.S. Patent 3,565,074; U.S. Patent No. 2,922,420, the entire contents of which are incorporated herein by reference.

The cannula associated with various embodiments is of a cylindrical configuration extending from the proximal end to the distal end. The length from the proximal end to the distal end is the first length along the length of the cannula. In various embodiments, the cannula has a bend, wherein the first length is longer than the linear length from the proximal end to the distal end. In one embodiment, the cannula is formed with a constant circumference. The cannula may be differentiated by an inner diameter and an outer diameter. In one embodiment, the outer diameter is from about 0.0355 to about 0.03600 mm and the inner diameter is from about 0.0230 to about 0.0245 mm. In an alternate embodiment, the outer diameter is about 0.0205 to 0.28 mm and the inner diameter is 0.0155 to 0.0170 mm. In various embodiments, the inner and outer diameters may be of any desired length, and the particular length is not limited within the scope of the appended claims.

In various embodiments, the shaped tip end or distal end of the at least partially hollow cannula can be of various shapes. In one embodiment, the distal tip is in the form of an angular plane with a general bevel shape. In another embodiment, the distal tip is rectangular in shape perpendicular to the longitudinal plane of the cannula. In another embodiment, the distal end tip is partially beveled, wherein the tip of the shaped tip is in a conventional bevel shape and the remainder of the tip is formed in a non-beveled shape such as a stepped shape. The various shapes are contemplated to be used to achieve the desired result during processing of the open end.

In various embodiments, the connector is about the proximal end of the cannula. The connector is used as an attachment means for the cannula and as an additional medical device. The connection in the connector may be a non-exemplary common connection type, such as, for example, a luer connection, a threaded attachment, a fitting connection, a clamp, a system using a dowel, have.

The probes with flexibility of the various embodiments extend through at least a portion of the hollow portion of the cannula. In some embodiments, the probe is characterized by a length and an outer diameter that extend from the proximal end to the distal end to indicate the first length. In various embodiments, the outer diameter is smaller than the first inner diameter of the cannula. In various embodiments, the probe may be longer than the first length. In many embodiments, the probe includes an at least partially hollow side port. In one embodiment, the probe and the cannula form a passage for at least one drug.

In various embodiments, the material of the configuration may be a probe portion that is flexible to flex within the hollow cannula to conform to its internal shape. In many embodiments, the material of the structure of the probe having flexibility is a polymeric material. In many embodiments, the material may be formed of a material that is biocompatible. Examples of such embodiments include materials such as polyethylene, polypropylene, polyfluorocarbon. In alternative embodiments, the material of which construction is made may be of a metal material. Exemplary embodiments include steel alloys, titanium alloys, and aluminum. In various embodiments, the probe may exhibit an elastic deformation with respect to removal and insertion from the cannula.

In various embodiments, the flexible probe can be inserted into the cannula, wherein the distal tip of the probe is disposed within the cannula at any point. In one embodiment, the proximal portion of the probe is disposed so that the proximal portion of the probe is even with the proximal portion of the cannula relative to the proximal portion of the cannula. In an alternative embodiment, the proximal portion of the probe extends past the distal end of the cannula. In an alternative embodiment, the distal end of the cannula extends past the proximal end of the probe.

In various embodiments, the flexible probe has a molded distal tip that does not support only safety features that provide a smooth or flat leading surface compared to the sharp or rigid edge of the distal tip of the hollow cannula, Providing a means for the tip tip of the system to be retracted when the flexible tip from the hollow cannula is partially disengaged or completely disengaged from its tip position to retract the shaped tip of the probe having flexibility . In some embodiments, the shaped tip is rounded into a semi-domed or bullet-like shape. In many embodiments, the shaped tip can be flattened in a manner that it is square with the length of the probe. In many embodiments, the shaped tip can be a conventional bevel angle. In many embodiments, the shape of the tip almost corresponds to the formation of the distal end of the cannula. In many embodiments, the shaped end of the probe having flexibility is formed in a manner that forms a flat surface at the same height as the distal end of the cannula. In many embodiments, the shaped tip may be edge-shaped or pointed so that at least a portion of the distal end edge of the probe section can penetrate tissue that a general insertion procedure can not penetrate. In many embodiments, the shaped tip of the probe is a point.

Various embodiments may leave the flexible probes and cannulas permanently connected or releasably connected or unconnected. In another embodiment, the probe can slide within the cannula. In another embodiment, the probe is releasably secured within the cannula by a fastening mechanism such as, but not limited to, a luer fastener, a fitting engagement, a snap, a screw thread, In an embodiment of the luer fastening system, the inner waterbody luer threads are disposed in or about adjacent probes to receive and connect cannulae having arm member luer threads thereon. In another embodiment, the luer fastener can be reversed. In another embodiment, the cannula is welded or otherwise fixedly connected to the cannula.

Additional embodiments include a cannula or probe having multiple ports arranged in any direction relative to the shaft. In one embodiment, the probe includes a lateral port across the cannula and a lateral port across the probe during application. In various embodiments, the side ports are positioned such that a reasonable alignment of the side ports occurs at the desired location of the probe within the cannula so that the drug passes therethrough across the rationally aligned side port.

Various embodiments include wires or other means that deliver a stimulus to the target tissue. In one embodiment, the wire extends from the proximal end along the distal buccal cannula of the distal tip. In another embodiment, the wire is integrally formed with the cannula (attached to the cannula). In another embodiment, the wire extends along the outside of the cannula. In another embodiment, the wire extends along the probe or through the probe, or is formed integrally with the probe.

Design considerations implemented with various embodiments include, but are not limited to, designing the wires and connectors to use a plug and use type of structure. The plug and use structure has the advantage that such a plug and use structure reduces the complexity of the device and reduces loose wires. In one embodiment, the wire is formed into a connector such that when the connector is connected to another medical device, the wire is able to communicate with the medical device. However, any connection common in the art for enabling a wire to communicate with a medical device may be implemented in various embodiments.

Various embodiments include a cannula, a probe, or at least one shaped insulation that is insulating against the wire. As will be appreciated by a person skilled in the art, any material of the structure providing the electrical or thermal insulation may be plastic, rubber, metal, non-metal, or the like, but is not limited thereto. In one embodiment, the insulation covers the exterior of the hollow cannula along the entire first length. In many embodiments, the insulation covers the outside of the hollow cannula until it reaches the rigid curve of the hollow cannula. In many embodiments, the insulation covers the outer portion of the hollow cannula between the hub and the rigid curve.

 Various embodiments include a wire comprised of a material that permits a difference between the insulating and hollow cannula or probe material with flexibility, probes with flexibility, and an insulation around the hollow cannula when using real time processing .

A variety of methods, including but not limited to fluoroscopic guiding, NMR, X-ray, direct observation, and the like, are used during medical procedures to determine the location of the target and the position of the safety nerve infusion system . In this embodiment, the practitioner chooses an embodiment with an insulating coating, wherein the difference in absorbency or reflectance between the insulating coating and the non-dissimilar portion of the safety nerve injection system can be distinguished in real time using a selected real-time observation system . For example, a particular isolator absorbs energy from a real-time observation system and appears dark, while a non-isolator reflects energy and appears bright. In this embodiment, the difference in reflectivity and absorbency provides a method for determining the lateral port of the safety nerve needle in relation to a treatment area given relative distance from the molded tip, distal tip, insulating / non-edge boundaries .

E. Specific Example

Figure 1 shows an embodiment of a safety nerve infusion system 1 with a cannula 10 (shown in plan and side views) and a probe 20 with flexibility in an isolated manner. The cannula 10 has a first length measured from the proximal end of the probe attachment hub 44 to the distal end opening 46 of the distal tip 40. In this embodiment, the cannula 10 has a hollow cannula shaft 34 having a rigid curvature 38 near its distal end and is provided with a lining portion of the insulation 36 of the cannula shaft 34 do. The isolation portion isolates the radio frequency (RF) portion of the cannula to isolate RF wires and the like. However, various embodiments include cannulas without insulation.

In one embodiment, the side port 48 is disposed in the rigid curve 38 of the hollow cannula shaft 34 adjacent the distal tip 40 and distal opening 46. However, the side port does not exist in various other embodiments. At the proximal end of the cannula 10, the hub 42 has an index mark 43 to visually inform the user of the curvature direction in which the rigid curve 38 is oriented. In addition, the index notch 50 disposed on the probe hitching hub 44 tactically performs a similar function to indicate a directional perspective of the rigid curve 38. The probe coupling hub 44 includes a probe receiving notch 60 for fixedly connecting the probe unit 20 having flexibility and fixing the probe unit 20 in a directional position.

In this embodiment, the flexible probe 20 includes a probe clamping notch 58 configured to engage the probe receiving notch 60 in a frictional engagement manner, a probe shaft 54 and a shaped probe tip (56). The probe shaft 54 is characterized by having a length of at least a first length relative to a first length of the cannula 10. The probe shaft is characterized by being made of a material that has a structure that permits resilient restoration even after being extended in the hollow cannula (10) with a rigid curve (38).

Figure 2 illustrates another embodiment of a safety needle injection system in which a probe 20 that extends beyond a first length of the cannula 10 having a shaped tip 56 and is flexible includes a side port 48 Is coupled and coupled to a cannula 10 having a distal end tip 40, a rigid curve 38,

Figures 3A-3E illustrate several embodiments of the distal end tip 40 of the cannula 10 with the shaped tip 56 of the probe 20 having flexibility. Figure 3A shows an example of a shaped tip 56 that is molded into a rounded end and extends beyond the end of the traditional bevel shape of the distal tip 40. [ Figure 3a shows a probe 20 having a probe shaft 54 having a length greater than the first length of the connected cannula 10 because the probe 20 ) Extends beyond the point at the farthest point of the distal tip 40. Figure 3b shows an example of a partially beveled distal end tip 56 at the distal end of the cannula 10 that matches the tip of the flexible probe 20, The shape corresponds to the angle of the beveled portion of the distal tip 56 and forms a flat surface at the partially equal height at the open distal end 40. The composite shape, which is flush and forms the surface of the beveled feature, is intended to be used to prevent tearing and catching of the distal end tip on a portion of the body by the rectangular portion of the distal tip 40. FIGS. 3c and 3d illustrate a rectangular tip 40 as a probe tip 56 having a flexibility that extends beyond the first length. 3C shows an example of a rounded point or pen point shape for the shaped tip 56. As shown in FIG. FIG. 3D shows an example of a sharp tip point for the shaped tip 56. Figure 3e illustrates the needle tip described in U.S. Patent No. 5,810,788, the entire contents of which are incorporated herein.

Figure 4 shows an alternative embodiment of a safety nerve infusion system with a cannula 110 (shown in plan and side views) and a coupled probing portion 120 in a separate state. The cannula 110 has a first length measured from the proximal end of the probe coupling hub 144 to the distal end opening 146 of the distal tip 140. In this embodiment, the cannula 110 has a hollow cannula shaft 134 with a rigid curvature 138 near the proximal end.

At the proximal end of the cannula 110, the hub 142 is provided with an index mark 143 for visually indicating the direction in which the rigid curve 138 is oriented to the user. In addition, the index notch 150 disposed on the probe coupling hub 144 tactilely performs a similar function to inform the user of the direction of the rigid curve 138. The probe coupling hub 144 includes a probing portion receiving notch 160 to fixedly connect the probing portion 120 having flexibility and fix the probing portion 120 so as to have a directional position.

In this embodiment, the flexible probe 120 includes a probe hub 152 having a probe closure notch 158 configured to engage the probe receiver notch 160 in a frictional engagement manner, A sub-shaft 154 and a shaped probe tip 156. The probe shaft (154) has a length associated with at least a first length of the cannula (110). The probe shaft is characterized by being made of a material that allows for resilient restoration even after being joined and extended within a hollow cannula (110) with a rigid curve (138).

FIG. 5 illustrates an alternative embodiment of a neuroinjection system with a coupled probe 184 and cannula 170 in a connected state. The cannula 170 has a first length measured from the proximal end of the probe mating hub to the distal end opening 186 of the distal tip 188. In this embodiment, the cannula 170 is straight and has at least a semi-grid hollow cannula shaft 174.

At the proximal end of the cannula 170, the hub 178 is connected to the reservoir 172. Indexing on probe hub 178 and second probe hub 182 is also used to provide a tactile and / or visual indication of the position of the probe within the cannula 170 to the user.

In this embodiment, probe 184 and cannula 170 form a fluid flow path wherein a user removes probe 190 from distal end opening 186 without removing probe 184 To inject the drug as shown. According to this embodiment, it becomes possible to inject the drug around the nerve tissue damaged by the cannula without the protection portion of the probe. In this embodiment, the probe 184 extends beyond the cannula shaft 174 and is capable of providing a buffer for nerve tissue. In various embodiments, the probe extends through the cannula shaft.

FIG. 6 shows an alternative embodiment of a neuroinjection system with a coupled probe 214 and cannula 200 in a coupled state. The cannula 200 has a first length measured from the proximal end of the probe mating hub 206 to the distal end opening 216 of the distal tip 218. In this embodiment, the cannula 200 has a curved hollow cannula shaft 204.

At the proximal end of the cannula 200, the hub 206 is connected to a reservoir line 202 that can supply drugs or other fluids such as liquids or gases. Indexing on the probe hub 206 and the second probe hub 212 is also used to tactually and / or visually inform the user of the position of the probe within the cannula 200.

In this embodiment, probe 214 and cannula 200 form a fluid flow, wherein the user removes probe 214 from spray opening 210 from spray opening 210 without removing probe 214. < RTI ID = 0.0 > So that the drug can be injected as described above. This embodiment can be used to inject a drug around the nerve tissue damaged by the cannula without the protection of the probe. In this embodiment, the probe 214 extends beyond the cannula shaft 204 and can provide a buffer for nerve tissue.

10: cannula 20: probe having flexibility
34: cannula shaft 36: insulating part
38: Rugged curved portion 40: Fabric tip
42: hub 43: index mark
44: Probe coupling hub 46:
48: side port 50: index notch
52: probe hub 56: molding tip
60: Probe acceptance notch 110: Cannula
120: probe having flexibility
134: hollow cannula shaft 138: a rigid bend
140: Fabric tip 142: Hub
143: Index mark 144: Probe coupling hub
146: distal end opening 152: probe hub
160: probe accepting notch 170: cannula
172: reservoir 174: cannula shaft
176 probe hub coupling hub 178 probe hub
182: Second probe hub 184: Coupling probe
186: End opening 188: End tip
190: Spray mark 200: Cannula
204: hollow cannula shaft 206: probe attachment hub
212: second probe hub 214: coupling probe
216: far end opening 218: far end tip

Claims (15)

A safety nerve infusion system,
An at least partially hollow hollow cannula formed by a first inner diameter, a first outer diameter, a first length, and an open distal end, wherein the open distal end is in fluid communication with the inside and outside of the hollow cannula A cannula;
A side port disposed coaxially along a lateral axis of the hollow cannula in fluid communication between the inside and outside of the hollow cannula;
And a probe having a flexible tip with a shaped tip,
The flexible probing portion releasably fastened in a first position within the hollow cannula and extending to at least a first length of the hollow cannula; Wherein the hollow cannula adjacent the distal end includes a rigid bend for positioning the distal end in a target area, wherein the probe and the hollow cannula form at least one channel,
The first position being a position such that the shaped tip of the probe with flexibility is at a position at the same height with respect to the open distal end of the hollow cannula,
The shaped tip is adapted to form a flat plane across the open distal end,
At least one of said channels being formed in said hollow cannula. The method according to claim 1,
A therapeutic agent, a therapeutic agent, a diagnostic agent, or a prophylactic agent. 3. The method of claim 2,
Wherein the therapeutic agent is an anesthetic agent. The safety nerve injection system of claim 1, further comprising a connector. The safety nerve injection system of claim 1, further comprising a probe. 3. The method of claim 2,
Further comprising a wire,
Wherein the wire is connected to a connector with the device. 2. The safety nerve injection system of claim 1, wherein the probe further comprises a side port. Positioning a target area for administration;
Adjusting the safety nerve injection system such that the safety nerve injection system of claim 1 is positioned relative to the target area;
Inserting at least a portion of the safety nerve injection system into the target area;
Operating the safety nerve infusion system using a rigid curve adjacent the distal end to set the position of the safety nervous system in the target area;
A method of injecting a drug into a neural tissue of an animal other than a human, comprising administering an agent to the target area. 9. The method of claim 8,
Wherein the agent is selected from the group consisting of a therapeutic agent, a diagnostic agent, or a prophylactic agent. 10. The method of claim 9,
Wherein the therapeutic agent is an anesthetic agent, wherein the drug is injected into the nerve tissue of an animal other than a human. 9. The method of claim 8,
Wherein the agent is a biopsy needle. 9. A method for injecting a drug into a nerve tissue of an animal other than a human. 9. The method of claim 8,
The method further comprising a tissue stimulation step comprising ablating at least a portion of the tissue. ≪ RTI ID = 0.0 > 18. < / RTI > 9. The method of claim 8,
Wherein the target region is selected from the group consisting of digestive system, circulatory system, nervous system, muscle system, skeletal system, respiratory system, urinary system, reproductive system, excretion system, endocrine system and immune system of an animal other than a human. How to inject drugs into tissues. A kit comprising the safety nerve injection system of claim 1 and an agent to be administered. 15. The method of claim 14,
Wherein said agent is selected from the group comprising therapeutic agents, diagnostic agents or prophylactic agents.

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