KR20130092260A - Composition for anti-dandruff - Google Patents

Abstract

PURPOSE: An anti-dandruff scalp composition is provided to ensure an anti-dandruff effect without a side effect by containing an extract of Lonicera japonica and at least one kind of extracts selected from the group consisting of Platycodon grandiflorus, Adenophorae radix, Aurantii fructus and Sasa borealis. CONSTITUTION: An anti-dandruff scalp composition contains at least one kind of extracts selected from the group consisting of Lonicera japonica, Platycodon grandiflorus, Adenophorae radix, Aurantii fructus, and Sasa borealis. The extract contains at least one extract selected from the group consisting of an extract using organic solvents, a water extract using water, an extract by boiling, and a supercritical extract. The extract of Lonicera japonica, Platycodon grandiflorus, Adenophorae radix, Aurantii fructus, or Sasa borealis is contained in an amount of 0.0001-50 weight%, relative to the total weight of the composition.

Description

Scalp composition for anti-dandruff {Composition for anti-dandruff}

The present invention relates to an anti-dandruff scalp composition comprising an extract of a sinus flower and one or more extracts selected from Gil Gyeong, Sasam, Crust, and Mt. The present invention relates to an anti-dandruff scalp composition that includes the perceptual extract as an active ingredient and has been proved experimentally without any side effects.

Dandruff is a kind of dictionary, which occurs when fat or dust gets on keratin, which naturally falls off the skin surface of the head.

The scalp, like hair, produces and replaces new scalp, which is replaced with new cells about once a month at a faster rate than hair. In a healthy scalp, the cells of the Horny Layer or Stratum corneum are rapidly replaced by new keratinocytes, falling off to an invisible size. However, the excessive production of keratinocytes and clumps of keratinocytes are visible and peeled off the scalp is called dandruff.

Dandruff is more common in males than females, and there is little dandruff in children under 10 years of age, but it is very common in puberty as it increases through infants and children.

Similar to dandruff, psoriasis and seborrheic dermatitis, which are similar to dandruff that occur in the same scalp and are confused, are different from dandruff. First of all, unlike psoriasis or seborrheic dermatitis, psoriasis can occur throughout the body, and seborrheic dermatitis occurs in the most seborrheic parts of the body, especially on the face. Psoriasis and seborrheic dermatitis accompany inflammatory reactions such as erythema, but dandruff has nothing to do with inflammatory reactions.

There are many causes of such dandruff, first of all there is an increase in sebum secretion. Malassezia suspected to be the main cause of dandruff Microorganisms in the genus use fatty acids to deplete the exogenous fatty acids required by the skin. Therefore, it is known that the sebum production is increased and secreted in order to obtain the required fatty acid, and the sebum is excessively secreted by this mechanism, which causes keratinocytes to aggregate into clumps, causing dandruff. In addition, the action by free fatty acids generated by sebum decomposition by lipase enzymes may be one of the causes. Sebum secreted from the skin is broken down by lipase enzymes to produce free fatty acids, which are known to directly or indirectly induce scalp irritation and skin damage causing dandruff. This process is called lipolysis mechanism.

In addition, the most important factor is the action by the microorganism. mainly Malassezia restricta or Malassezia Dandruff-causing organisms, such as globosa , are found twice as many as those found in normal scalp in patients with dandruff.

Another cause of scalp Increased cell division. This means an increase in cell division caused by metabolic abnormalities but not by enzymes and fatty acids.

Another cause is abnormal keratinization (parakeratosis) caused by parakeratase, which produces excessive keratinocytes, leaving cell nuclei in the stratum corneum of the epidermis, resulting in incomplete keratination, resulting in dandruff.

There are many other factors such as stress, environmental factors, food factors, and genetic factors.

Despite these various causes, most anti-dandruff products on the market are currently using antibacterial ingredients for the purpose of inhibiting dandruff growth and alleviating dandruff.

These ingredients include Zinc Pyrithione, Selenium Sulfide, Pyroctone Olamine, Climbazole, Salicylic Acid, Ketoconazole, and Coal Tar. ), Corticosteroid, colloidal sulfur, selenium disulfide, and the like.

However, most of these anti-dandruff agents are characterized by strong bactericidal power, and most of them have side effects or toxicity, so it is difficult to use a certain amount or more.

Therefore, in the present invention, in order to minimize toxicity or side effects, anti-dandruff compositions were prepared for natural herbal medicines, and by the normalization of the scalp by the principle of oriental medicine, not anti-dandruff effect limited to antibacterial function, by making a healthy scalp and basically dandruff Mitigate the occurrence

Looking at the cause of such dandruff from a one-sided view, the skin is dried by the heat in the body, which is caused by the exfoliation of keratinocytes from the skin, which is considered to promote the better conditions for the growth of bacteria by heat.

Therefore, the treatment of dandruff from this herbal point of view approaches by cooling the heat, relieving inflammation, washing the area.

In view of the above, the present inventors have selected natural extracts effective for each cause, and have found that they exhibit excellent antidandruff by the combination of these extracts, thus completing the present invention.

It is an object of the present invention to provide an anti-dandruff scalp composition having an anti-dandruff effect, which includes an extract of an artificial flower and one or more extracts selected from Gilkyung, Sasam, Crust, and mountain bamboo leaves.

In one embodiment of the present invention, honeysuckle flower extract; And it provides an anti-dandruff scalp composition comprising one or more extracts selected from Gilkyung, Samsam, crust and mountain bamboo leaves.

In one embodiment of the present invention, the extract comprises one or more extracts selected from water extracts, bath extracts and supercritical extracts using an extract or water using an organic solvent using an extracting solvent, the extracting solvent is purified water ; Lower alcohols such as methanol, ethanol, 1-propanol, isopropyl alcohol or butanol; Polyhydric alcohols of glycerol, ethylene glycol, propylene glycol or 1, 3-butylene glycol; And hydrocarbon solvents such as petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane or chloroform.

In addition, during the extraction, the amount of the extraction solvent added is preferably 5 to 20 ml per 1 g of the dry weight of the natural material. Extraction conditions of the natural product material may be used by immersion extraction for 1-7 days at room temperature or 1-5 hours extraction under a heating condition of 50 ~ 95 ℃, but is not limited to these general solvent extraction used in the art All of the methods can be applied. The natural products may be extracted by cooling by immersing the natural products in 70% ethanol for a predetermined time at room temperature, and the extract may be obtained and used by filtration.

In one embodiment of the present invention, the extract of the Apricot flower, Gilgyeong, Sasam, Crust or mountain bamboo leaf contains 0.0001 to 50% by weight, preferably 0.001 to 20% by weight based on the total weight of the composition. . Less than 0.001% by weight of the anti-dandruff effect is insignificant, and higher concentration than 50% by weight is unfavorable because the discomfort is large compared to the effect that appears to be difficult to apply the formulation.

In one embodiment of the present invention, a topical topical anti-dandruff agent is provided that can be applied to the scalp in the form of an external solution, cream, ointment, paste, aerosol, gel, or wax containing the composition.

In one embodiment of the present invention, it provides a cosmetic composition that can be applied to the hair in the form of a shampoo, rinse, ampoule, or treatment comprising the composition.

In addition, the composition of the present invention, in consideration of the properties of the hair, may be added to the auxiliary ingredients such as moisturizers, hair root enhancer, hair repair agent, scalp protector, cooling agent, antistatic agent, etc. Can be used, but is not limited thereto. These auxiliary ingredients can be used within the scope for maintaining the formulation without disturbing the effects of the main ingredient.

By the use of the composition according to the invention has an excellent anti-dandruff effect, by the effect of the natural extract contained in the composition to cool the scalp, to reduce inflammation, to clean the scalp, to form dandruff by abnormal hyperkeratosis It has the advantage of normalizing the scalp while relieving it, giving an excellent antidandruff effect.

The present invention will be described in more detail as follows.

The main component of the present invention is a honeysuckle, which is a bud of Lonicera japonica Thunberg. This drug is a mixture of small rods or funnel-shaped buds and often lip-shaped flowers, 15-35 mm long. The outer surface is white to yellowish brown and magnified with light brown hairs and there are 5 stamens. Honeysuckle has an unusual aroma and tastes a little sweet. Pharmacological actions include antibacterial action, antiviral action, antifungal action, astringent action, and diuretic action. Its main effect is clear heat detoxification (淸 熱 解毒) means to treat heat poisoning by fever and detoxification. The main ingredients are inositol, luteolin, and tannin.

Another major component of the present invention, Gilyeong, also known as Gil-Gil-Geun, is the root of Platycodon grandiflorum A. De Candolle as it is or without the cuticle. This drug is irregularly long, long fusiform to conical, sometimes branched, and the outside is gray brown, light brown or white. The freckles are 10-15cm long, and now 1-3cm. It has a slight smell and tastes bad at first, but later it is bitter and bitter. This drug should be gray brown, hard, 5cm long, 1cm in diameter and higher in saponin. Pharmacological action, expectoration effect, antitussive action, anti-whaeng bacterium effect (抗 白 癬菌 作用), etc., the effect is a pre-lung expectoration (담), drainage (排膿) action. The main ingredients are Platycodin A, Platicodin C, Platicodin D1, Platicodine D2, Polygalacin D1, Polygalacin D2, Betulin, Inulin ), Phytosterol.

Another major component of the present invention, Samsam is Adenophora triphylla var. japonica Hara and the roots of the same species (Prariaceae Campanulaceae). I am a perennial plant in mountainous regions of our country, 50-100 cm tall, with hairs all over, white and thick roots. Root leaves have long petioles, almost circular. Foliage leaves are regenerated or reincarnation, oval or ovate, petiole short or absent, sharp at both ends, and edges have double teeth. Sex is insignificant and taste is bitter. Its main ingredients are essential oils and saponins, and its efficacy is yunhwajihae (양), Yang Sansengjin (養胃 生 津), expectoration (祛痰), gugal (口渴).

Another major component of the present invention is the crust, which is split into two unripe fruits of Citrus aurantium Linne. This medicine has an aroma and tastes slightly bitter. The main ingredients are limonene (Limonene), linalool (Linalool), poncirin (naringin), the properties are flat.

Another major component of the present invention, mountain bamboo leaf, is known as a leaf of (Sasa boreails (Hack.) Mak.) Mountain porridge. Drug efficacy is clear, detoxification, anti-cancer effect, and is known to be effective in hypertension, diabetes, chronic hepatitis, gastric ulcer.

Hereinafter, the present invention will be described in more detail with reference to the following examples and experimental examples. However, these examples and experimental examples are provided only for the understanding of the present invention, and are not intended to limit the scope of the present invention.

Example  1. Preparation of Extract

First, after filtering out the impurities of the honeysuckle flower, Gilkyung, samsam, crust, and mountain bamboo leaves, ethanol and purified water according to the standards set forth in the Korean Pharmacopoeia were added about 4 to 10 times and cooled at room temperature for 5 days. The extracted stock solution was filtered using Whatman # 3 filter paper, and the filtered extract was completely evaporated at 45 ° C. using a vacuum condenser to prepare a dried extract.

Example  2 to 4. Antidandruff  Preparation of the composition

An antidandruff composition was prepared according to a conventional method known in the art with the composition shown in Table 1 from the phosphorus flower and Gilgyeong, Sasam, Crust, and mountain bamboo leaf extract prepared in Example 1.

Comparative example  1 to 4

Comparative Examples 1 to 4 prepared an antidandruff composition according to a conventional method known in the art in a configuration that does not include all of the artificial flowers and Gilyeong, ginseng, crust, and mountain bamboo leaf extract as shown in Table 1 below.

Ingredients (% by weight) Comparative Example 1 Example 2 Example 3 Example 4 Sodium lauryl sulfate 10 10 10 10 Cocamidopropyl betaine 3 3 3 3 Carboxyl vinyl polymer 0.3 0.3 0.3 0.3  Polyquaternium-10 0.2 0.2 0.2 0.2 incense 0.7 0.7 0.7 0.7 Methyl paraben 0.2 0.2 0.2 0.2 Cetyltrimethylammonium chloride 0.1 0.1 0.1 0.1 Honeysuckle Flower Extract 0 5 3 One Gilyeong extract 0 5 3 One Samsam Extract 0 5 3 One Crust Extract 0 2 One One Mountain Bamboo Leaf Extract 0 2 One One Purified water Residual amount Residual amount Residual amount Residual amount

Experimental Example  1. Using Dandruff Antidandruff activity  evaluation

Experimental methods mainly used for the study of anti-dandruff effects include the method of evaluating anti-dandruff activity against fungi known to cause dandruff such as Malassezia globosa and Malassezia restricta, compared to before and after the use of the composition in dandruff patients. The method of performing anti-dandruff activity is used.

In the present invention, anti-dandruff activity test was performed on Malassezia globosa, Malassezia restricta, which are dandruff bacteria, using the extract of Panaxiasis, Gilkyung, Sasam, Crust, and Mountain Bamboo Leaf obtained according to Example 1.

Malassezia globosa and Malassezia restricta are known to cause dandruff. By-products and fungi produced during the use of sebum on the scalp are known to cause dandruff. Therefore, anti-dandruff activity can be inferred by evaluating antimicrobial activity against both species.

After inoculating the two species in Modified dixon agar medium, 20ul of diluted sample was dropped on a paper disk and incubated at 30 ° C for 3-7 days, and then the size of the generated clear zone was measured. Was measured.

Each sample was used for the experiment prepared samples according to Comparative Example 1 and Example 2. Each sample was diluted to 10% concentration and used for the experiment. The results are shown in Table 2 below, respectively.

Comparative Example 1 Example 2 Measurement 1 0 mm 4.5 mm Measurement 2 0 mm 4.3 mm Measurement 3 0 mm 4.2 mm Average 0 mm 4.3 mm

As shown in the results of Table 2, Example 2 containing the artificial flowers and Gilyeong, Sasam, crust, mountain bamboo leaf extract was confirmed that the clear zone showing the anti-dandruff bacterium appeared widely, Comparative Example 1 does not contain the extract It was confirmed that the anti-dandruff activity was not shown.

As a result, it could be confirmed that the sample containing honeysuckle and Gilgyeong, Samsam, crust, and mountain bamboo leaf extract showed anti-dandruff effect by exhibiting anti-dandruff activity.

Experimental Example  2. Clinical Trials for Dandruff Patients

In order to investigate the effects on dandruff patients, clinical trials were conducted in patients with dandruff.

As a test subject, adult men and women aged 20 years or older, who had dandruff, were shampooed once a day, 5 people per sample, and performed for at least 2 weeks to 1 month.

The determination of the effect was evaluated in five stages according to the following evaluation scales to determine the photographic judgment of the dandruff lesion site and the improvement of subjective symptoms (Table 3). The results are shown in Table 4 below.

step Visual judgment Subjective symptoms One Got worse Got worse 2 No change No change 3 Slightly improved Slightly improved 4 Improvements were made. Improvements were made. 5 Remarkably improved Remarkably improved

division Visual judgment Subjective symptoms Comparative Example 1 2.0 2.1 Example 2 4.5 4.8 Example 3 4.1 4.3 Example 4 3.8 4.0

As shown in the results of Table 4, it was confirmed that in Examples 2 to 4 including the extract than in Comparative Example 1 without the extract, excellent anti-dandruff power in both visual judgment and subjective symptoms.

In addition, no adverse effects were found in all subjects during the trial period, indicating that they are safe for humans.

Taken together, the samples containing honeysuckle, Gilkyung, samsam, crust, and mountain bamboo leaf extract showed better anti-dandruff activity in the anti-dandruff test compared to the sample which did not contain it. One clinical trial showed a very good effect.

Therefore, it can be seen that the composition containing honeysuckle and Gilgyeong, Sasam, Crust, and mountain bamboo leaf extract exhibits an excellent antidandruff effect while being effective in the human body.

Example  5-7. Preparation of hair and scalp application compositions in the form of shampoos

To prepare a hair and scalp application composition of the shampoo form including the honeysuckle and Gilkyung, ginseng, crust, mountain bamboo leaf extract obtained according to Example 1 above.

Ingredients (% by weight) Example 5 Example 6 Example 7 Sodium lauryl sulfate 10 10 10 Cocamidopropyl betaine 3 3 Carboxyl vinyl polymer 0.3 0.3 0.3  Polyquaternium-10 0.2 0.2 0.2 incense 0.7 0.7 0.7 Methyl paraben 0.2 0.2 0.2 Cetyltrimethylammonium chloride 0.1 0.1 0.1 Honeysuckle Flower Extract 5 3 One Gilt Extract 3 One 0.5 Ginseng extract 3 One 0.5 Crust extract 2 One 0.5 Mountain Bamboo Leaf Extract 2 One 0.5 Purified water Residual amount Residual amount Residual amount

Example  8 to 9. Preparation of Hair and Scalp Application Compositions in Rinse Form

To prepare a hair and scalp application composition of the rinsed form comprising the extract of Phosphorus and Gilgyeong, Sasam, Crust, mountain bamboo leaf obtained according to Example 1 above.

Ingredients (% by weight) Example 8 Example 9 Cetyl alcohol 2 2 Stearyl alcohol 2.5 2.5 Behenyl Alcohol 0.5 0.5 Spices 0.4 0.4 Silicone emulsion 0.4 0.4 Cyclomethicone 1.0 1.0 Dimethyl distearyl ammonium chloride 0.1 0.1 Citric acid Adjustable amount to pH 3-7 Adjustable amount to pH 3-7 Honeysuckle Flower Extract 5 3 Gilt Extract 5 3 Ginseng extract 5 3 Crust extract One 0.5 Mountain Bamboo Leaf Extract One 0.5 Purified water Residual amount Residual amount

Example  10. Preparation of hair and scalp application compositions in the form of ampoules

An ampule-type hair and scalp application composition comprising the extract of Phlophorae and Gilgyeong, Sasam, Crust, and Mountain Bamboo Leaf obtained according to Example 1 was prepared.

Ingredients (% by weight) Example 10 ethanol 30 Propylene glycol 20 1,3-butylene glycol 10 Cetyltrimethylammonium chloride 3 Dimethyl distearyl ammonium chloride 0.1 Lauryl Alcohol 3 Myristyl Alcohol 5 Cetyl alcohol One incense 0.5 dyes Proper amount Honeysuckle Flower Extract One Gilt Extract One Ginseng extract One Crust extract 0.3 Mountain Bamboo Leaf Extract 0 Purified water Residual amount

Example  11 to 12. tonic  Preparation of hair and scalp application compositions in the form

Tonic form hair and scalp application compositions were prepared, including the extracts of Panaxia eryngii, Ginseng, Ginseng, Crust, and mountain bamboo leaf obtained according to Example 1 above.

Ingredients (% by weight) Example 11 ethanol 40 Propylene glycol 10 Polysorbate 20 5 incense 0.5 dyes Proper amount Honeysuckle Flower Extract 0.5 Gilt Extract 0.5 Ginseng extract 0.5 Crust extract 0.1 Mountain Bamboo Leaf Extract 0.1 Purified water Residual amount

While the present invention has been described with reference to exemplary embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. You will know. In addition, many modifications may be made to adapt a particular situation and material to the teachings of the invention without departing from the essential scope thereof. Accordingly, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention be construed as including all embodiments falling within the scope of the appended claims.

Claims (7)

Honeysuckle flower extract; And
Anti-dandruff scalp composition comprising one or more extracts selected from Gilkyung, Sasam, Crust and Mountain Bamboo Leaf. The method of claim 1,
The extract is an anti-dandruff scalp composition, characterized in that it comprises one or more extracts selected from water extracts, water bath extracts and supercritical extracts using an extract or an organic solvent through the extraction solvent. The method of claim 2,
The extraction solvent is purified water; Lower alcohols such as methanol, ethanol, 1-propanol, isopropyl alcohol or butanol; Polyhydric alcohols of glycerol, ethylene glycol, propylene glycol or 1, 3-butylene glycol; And a hydrocarbon solvent of petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane or chloroform. The method of claim 1,
The extract of the honeysuckle flower, Gilgyeong, Samsam, crust or mountain bamboo leaf is anti-dandruff scalp composition, characterized in that it comprises 0.0001 to 50% by weight relative to the total weight of the composition. The method of claim 1,
The extract of the honeysuckle flower, Gilgyeong, Sasam, crust or mountain bamboo leaf is an anti-dandruff scalp composition, characterized in that it comprises 0.001 to 20% by weight based on the total weight of the composition. A topical topical application type of scalp that can be applied to the scalp in the form of an external solution, cream, ointment, paste, aerosol, gel, or wax, comprising the anti-dandruff scalp composition of any one of claims 1 to 5. Dandruff. A cosmetic composition that can be applied to hair in the form of a shampoo, rinse, ampoule, or treatment comprising the anti-dandruff scalp composition of any one of claims 1 to 5.