KR102575518B1 - Cosmetic composition for preventing hair loss or dandruff comprising herbal extracts - Google Patents

Abstract

The present invention relates to a cosmetic composition for preventing hair loss or dandruff comprising a crude drug extract. According to the present invention, there is an advantage in that excellent hair loss or dandruff prevention efficacy can be realized while securing stability to the skin by using natural raw materials.

Description

COSMETIC COMPOSITION FOR PREVENTING HAIR LOSS OR DANDRUFF COMPRISING HERBAL EXTRACTS}

The following examples relate to cosmetic compositions for preventing hair loss or dandruff containing herbal extracts.

Conventionally, the use of steroids and antifungals for the purpose of treating hair loss is increasing, but the prescription drug antifungal agent ketoconazole oral is subject to warning from the Ministry of Food and Drug Safety for side effects, and most antifungals are high in the health of patients and consumers. burden is increasing. Accordingly, in recent years, the development of drugs for preventing hair loss and materials for cosmetics has been demanded for the development of low-cost substances that are highly effective, non-toxic, and easy to mass-produce in a small dose that meets the needs of consumers.

On the other hand, dermatitis means inflammation occurring in the skin, and is usually used in the same sense as eczema. Dermatitis is largely classified into atopic dermatitis, contact dermatitis, and seborrhoeic dermatitis. In particular, the seborrhoeic dermatitis (seborrhoeic dermatitis) refers to dermatitis that often occurs in areas with a lot of sebum secretion, such as the head, forehead, or armpits, and is also called seborrheic eczema. The seborrheic dermatitis is dermatitis mainly composed of erythema and thin scales, that is, dandruff, and the mildest type is dandruff or scaly tetter. Dandruff can be aggravated by various factors such as genetic factors, external stimuli, food, androgen hormones, climate and seasonal factors, and develop into a skin disease. Excessive reproduction of Pityrosporum ovale has been identified as one of the causes of scalp disease and seborrheic dermatitis. Most of the anti-dandruff agents currently used in general anti-dandruff products are substances characterized by strong bactericidal power against Malassezia, and most of them are irritating and toxic to the skin, making it difficult to use more than a certain amount. Its content is strictly regulated.

Accordingly, Korean Patent Registration No. 10-1011191 discloses a first group mixture that softens hair and enhances surface activity and foam, a second group mixture that keeps the viscosity of shampoo constant, and a pH concentration of 3 to 9. Disclosed is a shampoo composition comprising a mixture of the third group that controls, and a mixture of the fourth group that refreshes the scalp, removes dandruff and prevents hair loss. However, there is an urgent need to develop a composition capable of implementing excellent anti-hair loss or dandruff effects while securing stability to the skin using natural raw materials.

Republic of Korea Patent Registration No. 10-1011191

The following examples are made to solve the above problems, and an object of the present invention is to provide a composition capable of implementing excellent anti-hair loss or dandruff effects while securing stability to the skin using natural raw materials.

In order to achieve the above object of the present invention, one embodiment of the present invention includes evening primrose extract, kudzu root extract, king pine leaf extract and sugar elm root extract as active ingredients, zinc pyrithione (Zinc Pyrithione), Provided is a cosmetic composition for preventing hair loss or dandruff, further comprising at least one antibacterial agent selected from the group consisting of Piroctone Olamine and Climbazole as an active ingredient.

According to the present invention, there is an advantage in that excellent hair loss or dandruff prevention efficacy can be implemented while securing stability to the skin by using natural raw materials and the like.

1 is a photograph showing the severity grade of scalp dandruff.
2 to 21 are images of subjects' scalp conditions measured.

Hereinafter, embodiments will be described in detail with reference to the accompanying drawings. However, since various changes can be made to the embodiments, the scope of the patent application is not limited or limited by these embodiments. It should be understood that all changes, equivalents or substitutes to the embodiments are included within the scope of rights.

Specific structural or functional descriptions of the embodiments are disclosed for illustrative purposes only, and may be modified and implemented in various forms. Therefore, the embodiments are not limited to the specific disclosed form, and the scope of the present specification includes changes, equivalents, or substitutes included in the technical spirit.

Although terms such as first or second may be used to describe various components, such terms should only be construed for the purpose of distinguishing one component from another. For example, a first element may be termed a second element, and similarly, a second element may be termed a first element.

When an element is referred to as being “connected” to another element, it should be understood that although it may be directly connected or connected to the other element, other elements may exist in the middle.

Terms used in the examples are used only for the purpose of explanation and should not be construed as limiting. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as “include” or “have” are intended to designate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, but one or more other features It should be understood that the presence or addition of numbers, steps, operations, components, parts, or combinations thereof is not precluded.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by a person of ordinary skill in the art to which the embodiment belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and unless explicitly defined in the present application, they should not be interpreted in an ideal or excessively formal meaning. don't

Advantages and features of the present invention, and methods of achieving them, will become clear with reference to the detailed description of the following embodiments taken in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in various different forms, only these embodiments make the disclosure of the present invention complete, and common knowledge in the art to which the present invention belongs. It is provided to fully inform the holder of the scope of the invention, and the present invention is only defined by the scope of the claims.

In the embodiments of the present invention, unless otherwise defined, all terms used herein, including technical or scientific terms, are the same as those commonly understood by one of ordinary skill in the art to which the present invention belongs. It has meaning. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and unless explicitly defined in the embodiments of the present invention, an ideal or excessively formal meaning not be interpreted as

The shapes, sizes, ratios, angles, numbers, etc. disclosed in the drawings for explaining the embodiments of the present invention are illustrative, so the present invention is not limited to the details shown. In addition, in describing the present invention, if it is determined that a detailed description of related known technologies may unnecessarily obscure the subject matter of the present invention, the detailed description will be omitted. When 'includes', 'has', 'consists of', etc. mentioned in this specification is used, other parts may be added unless 'only' is used. In the case where a component is expressed in the singular, the case including the plural is included unless otherwise explicitly stated.

In interpreting the components, even if there is no separate explicit description, it is interpreted as including the error range.

The size and thickness of each component shown in the drawings are shown for convenience of description, and the present invention is not necessarily limited to the size and thickness of the illustrated components.

Each feature of the various embodiments of the present invention can be partially or entirely combined or combined with each other, and as those skilled in the art can fully understand, various interlocking and driving operations are possible, and each embodiment can be implemented independently of each other. It may be possible to implement together in an association relationship.

Hereinafter, the present invention will be described in detail with reference to examples and drawings. However, it is apparent that the present invention is not limited by the following examples and drawings.

Cosmetic composition for preventing hair loss or dandruff

In one aspect, the present invention includes evening primrose extract, kudzu root extract, royal pine leaf extract, and sugar elm root extract as active ingredients, and zinc pyrithione, pyroctone olamine, and climbazole ( It provides a cosmetic composition for preventing hair loss or dandruff, further comprising at least one antibacterial agent selected from the group consisting of Climbazole as an active ingredient.

The present inventors have found that, in particular, when a combination of the above components is included as an active ingredient in the composition, there is an advantage in that it is possible to realize excellent anti-hair loss or dandruff effects while securing stability to the skin using natural raw materials and the like while reducing the burden on the human body. As a result, the present invention was completed.

In the present invention, the term "extract" means an active ingredient separated from a natural product, and can be obtained by an extraction process using water, an organic solvent, or a mixed solvent thereof, and an extract, a dry powder thereof, or a mixture thereof. It includes all forms formulated by The extracted liquid can be used directly or concentrated and/or dried to be used as a “powder”. For extraction using organic solvents, methanol, ethanol, isopropanol, butanol, ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, dichloromethane, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), 1,3-butylene glycol, propylene glycol, or a mixed solvent of these organic solvents are used, and the active ingredients can be extracted at room temperature or heated under conditions that are not destroyed or minimized. Depending on the organic solvent to be extracted, the degree of extraction and loss of the active ingredient of the medicinal material may differ, so select and use an appropriate organic solvent. The extraction method is not particularly limited, and examples thereof include hot water extraction, cold needle extraction, ultrasonic extraction and reflux extraction.

The solvent extract may further comprise filtering the extract to remove suspended solid particles. Particles may be filtered out using cotton, nylon, or the like, or ultrafiltration, cryofiltration, centrifugation, or the like may be used, but is not limited thereto. In the case of concentrating the extract, methods such as vacuum concentration and reverse osmosis concentration may be used. The drying step after concentration includes, but is not limited to, freeze drying, vacuum drying, hot air drying, spray drying, reduced pressure drying, foam drying, high frequency drying, infrared drying, and the like.

Prevention of hair loss or promotion of hair growth may be by one or more selected from the group consisting of dermal papilla cell proliferation, hair follicle stem cell activity increase, hair follicle growth phase induction, hair follicle growth phase maintenance or extension, and hair follicle cycle transition inhibition. The composition according to one aspect of the present invention increases the activity of hair follicle stem cells and promotes the proliferation of dermal papilla cells, thereby preventing hair loss, promoting hair growth, and various types of hair loss (androgenetic alopecia, scarred alopecia, alopecia areata, drug-induced alopecia, And one or more selected from the group consisting of alopecia caused by microbial infection) can be improved and treated.

In one aspect, the hair loss prevention or hair growth promotion may be due to increased transcriptional activity of beta-catenin (β-catenin) or increased activity of Wnt/β-catenin. The composition according to one aspect of the present invention increases the transcriptional activity of β-catenin or increases the activity of Wnt/β-catenin in a concentration-dependent manner, through which the hair follicle cycle is regulated (i.e., anagen induction and growth phase), therefore, one aspect of the present invention can be used for preventing hair loss, promoting hair growth, and treating various types of hair loss (androgenetic alopecia, scarlet alopecia, alopecia areata, drug-induced alopecia, and microbial infection-induced alopecia, etc.) There is.

Hair is a process of regularly repeating periodic changes in growth, regression, and resting periods, and each hair repeats independent creation and extinction. In the growth phase, hair follicle cells are surrounded by dermal papilla made of stromal cells and have a circular shape, and the growth phase is a time when cell division for the generation of new hair is active. The catagen phase is a time when hair follicle growth activity is suspended and rapidly atrophic, and the shape of the hair at this time resembles a club. The telogen phase is the period when the cell activity of the hair follicle is completely destroyed, and during the period of 2-3 months, it is pushed out by the anagen hair that newly grows from the base of the telogen hair, or falls out naturally by mechanical action such as combing or washing the hair. . In general, alopecia refers to the fact that during this cycle, the hair ratio in the anagen phase is shortened and the hair in the catagen or telogen phase increases, resulting in an increase in the number of hairs that fall out abnormally. Since the composition according to one aspect of the present invention induces, maintains, and prolongs the anagen phase of hair follicles and suppresses the transition to the catagen phase, the composition is used to prevent hair loss, promote hair growth, and various types of hair loss (androgenetic alopecia, wound alopecia, Alopecia areata, at least one selected from the group consisting of drug-induced alopecia, and microbial infection-induced alopecia) can be improved and treated.

The “prevention” means preventing something or a phenomenon from occurring, and in the present invention, preventing hair loss or dandruff means preventing hair loss or dandruff from occurring.

The "prevention" means any action to suppress or delay the disease by administration of the composition. The “improvement” refers to all actions that at least reduce a parameter related to a state, for example, the severity of a symptom.

herbal extract

In the above “evening primrose extract”, evening primrose is an annual plant and belongs to the needle family. The height reaches 1 meter, and the stem stands straight and rarely branches. There are short hairs all over the body, and the leaves are placed opposite each other at narrow intervals. The leaves are elongated lanceolates with sharp tips and a few sawtooth edges. There are about 80 species of needle flower and evening primrose in the world, and several species have been naturalized and grown in Korea, such as long-leaved evening primrose, large evening primrose, and baby evening primrose. In oriental medicine, the root of the evening primrose is used as a medicinal material called Wolgyeoncho, and when you have a high fever and sore throat due to a cold, you put it in water and decoct it, and the seeds are called Wolgyeonja and are used for hyperlipidemia. In general, it has antipyretic and anti-inflammatory effects, and is known to be effective in treating colds, sore throats, bronchitis, and dermatitis. Evening primrose seed oil has been a folk medicine applied by Indians for inflammation and rashes since ancient times, and has been passed down as a special medicine for asthma to white people. Evening primrose oil significantly reduces the amount of cholesterol and improves circulatory disorders and heart diseases such as myocardial infarction, arteriosclerosis, high blood pressure, and angina pectoris. In addition, the excellent efficacy of evening primrose oil for weight loss, rheumatoid arthritis, menstrual irregularity, alcoholism, and diabetes has been recognized.

In the above "Kudzu Root Extract", Kudzu is a perennial root plant, and about 10 or more species are distributed around the world, and one species (scientific name: Pueraria Radix) grows in Korea. It is a vine shrub that grows wild in mountains and fields all over the country. It is about 10m long, and the long-old roots store a lot of starch, so they make reed powder and use the stems for home crafts. , make Galpo (葛布). In oriental medicine, it is known to have effects such as sweating, antipyretic, antispasmodic, antispasmodic, sedation, sluggishness, and congestion. It is known that its flowers, leaves and roots are also effective. Kudzu root is very safe enough to be used for private consumption, and in some parts of Africa, it is cultivated as one of the food resources due to its high starch content.

In the above "Dawang pine leaf extract", Daewang pine belongs to evergreen conifers and is native to North America. It is an arboreous tree that grows to a height of 30~36m. It has 3 leaves with 3 leaves, and the leaves are soft and elongated. It can be planted in the central region of Korea because of its cold resistance, pollution resistance and strong vitality against pests and diseases. Including chlorophyll, which is a green chlorophyll, it helps to discharge toxins and maintain healthy skin, and gives conditioning to the skin to help maintain vitality and vitality.

In the above-mentioned "Elm tree root extract," Elm tree is a deciduous broad-leaved tree belonging to the Elmaceae family, and there is a study of Hongdeung, which reports that it has analgesic action, anti-edema action, leukocyte induction inhibitory action and antibacterial activity, and the root (+)-catechin, which is a flavonoid, and (+)-catechin-5-O-β-D-apiofuranoside as its glycoside, and friedelin and epi from bark. Three types of triterpenoids, epifriedelin and taraxerol, have been isolated and reported.

In one embodiment, in the composition, the content ratio of the evening primrose extract, kudzu root extract, king pine leaf extract, and sugar elm root extract is 1: 0.1 to 5: 0.1 to 5: 0.1 to 5 based on weight. Alternatively, the content ratio is 1:0.5 to 1.5:0.5 to 1.5:0.5 to 1.5 based on weight. Alternatively, the content ratio is 1:1:1:1 by weight.

antibacterial

The "Zinc Pyrithione" exhibits antibacterial and antifungal effects, and is particularly excellent in inhibiting dandruff.

The “Piroctone Olamine” is a hydroxypyridinone-based antifungal agent known to act by interfering with the active movement of essential cells. Since the pyroctoneolamine has antibacterial properties against Malassezia, it can be used for fundamental treatment of dandruff.

The "Climbazole" is a white crystalline powder, which has an exclusive and continuous bactericidal effect on ovoid nasal fungus and trichophytic bacteria, as well as a skin soothing effect, and prevents dandruff by blocking the generation pathway of fungi and dandruff bacteria. It stops itching and makes the skin soft and elastic.

In one embodiment, the antimicrobial agent is a mixture of Zinc Pyrithione, Piroctone Olamine and Climbazole, and the Zinc Pyrithione, Piroctone Olamine ) and Climbazole in a content ratio of 1: 0.001 to 0.01: 0.001 to 0.01 based on weight. Alternatively, the content ratio is 1: 0.0025 to 0.0075: 0.0025 to 0.0075 based on weight. Alternatively, the content ratio is 1: 0.004: 0.004 by weight.

conditioning agent

In one embodiment, the composition comprises Dexpanthenol, Salicylic Acid, Niacinamide, Glycine, Glutamic Acid, Glutamine, Lysine ), at least one conditioning agent selected from the group consisting of Leucine, Methionine and Valine as an active ingredient.

In one embodiment, the antimicrobial agent is a mixture of Dexpanthenol, Salicylic Acid and Niacinamide.

The “Dexpanthenol” is a derivative of pantothenic acid, which is used as an aid in the treatment of skin diseases such as wounds and diaper rash. It is known to relieve symptoms such as dermatitis and have anti-inflammatory and soothing effects. It has a conditioning effect on hair and skin.

The “Salicylic Acid” is a component known under the name of BHA, a substance that can remove dead skin cells from the skin (scalp) without high irritation, and is known as a substance that has a conditioning effect on hair and skin. .

The "Niacinamide" is well known as a whitening functional ingredient approved by the Ministry of Food and Drug Safety, and is known to be effective in improving skin tone, suppressing trouble occurrence, whitening effect, and improving skin barrier. It is known to have a conditioning effect on skin and hair. In one embodiment, the content ratio of Dexpanthenol, Salicylic Acid, and Niacinamide is 1:0.1 to 1:0.1 based on weight. 5: 0.1 to 1. Alternatively, the content ratio is 1:0.5 to 1.5:0.25 to 0.75 based on weight. Alternatively, the content ratio is 1:1:0.5 based on weight.

cosmetic composition

The cosmetic composition according to one aspect of the present invention is, for example, a composition for skin, nails and/or hair, which includes softening lotion, astringent lotion, nutrient lotion, nutrient cream, massage cream, eye cream, eye essence, essence, cleansing cream, Cleansing lotion, cleansing foam, cleansing water, pack, powder, body lotion, body cream, body essence, body cleanser, hair dye, shampoo, conditioner, hairdresser, hair conditioner, ointment, gel, cream, patch, spray, powder and skin It may have a formulation such as an adhesive type, but is not limited thereto.

In addition, other ingredients in addition to the essential ingredients described above in each formulation can be appropriately selected and blended without difficulty by those skilled in the art according to the type or purpose of use of other external preparations. The cosmetic composition may be provided in any formulation suitable for topical application. For example, it may be provided in the form of a solution, an emulsion obtained by dispersing an oil phase in an aqueous phase, an emulsion obtained by dispersing an aqueous phase in an oil phase, a suspension, a solid, a gel, a powder, a paste, a microneedle, a foam, or an aerosol composition. there is. Compositions of such formulations may be prepared according to conventional methods in the art.

The cosmetic composition according to the present specification may further include functional additives and components included in general cosmetic compositions in addition to the compounds, extracts, or fractions of the present specification. The functional additive may include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, sphingolipids, and seaweed extracts. The cosmetic composition according to the present specification may include other components capable of giving a synergistic effect to the main effect within a range that does not impair the main effect. In addition, the cosmetic composition according to the present specification may further include a moisturizer, an emollient agent, a surfactant, a UV absorber, a preservative, a bactericide, an antioxidant, a pH adjuster, an organic and inorganic pigment, a fragrance, a cooling agent or an antiperspirant. The compounding amount of the components can be easily selected by those skilled in the art within a range that does not impair the purpose and effect of the present specification, and the compounding amount may be 0.001 to 10% by weight, specifically 0.01 to 3% by weight based on the total weight of the composition. there is.

According to another embodiment, the composition may be an external composition for skin. Compositions for external application for skin may be compositions such as cosmetics, oral preparations, detergents, pharmaceuticals and quasi-drugs, but are not limited thereto. The skin external preparation is not particularly limited in its formulation. In addition, the composition for external application for skin of the present specification may further include at least one selected from a functional salt for a special purpose and a pH adjusting agent for adjusting pH. In this case, the salt may be selected from inorganic salts, organic salts, and/or organic-inorganic salts for ion shielding, moisturizing, and UV protection. For example, the salt may be selected from sodium chloride (NaCl), sodium phosphate (Na ₃ PO ₄ ), and calcium chloride (CaCl ₂ ). The pH adjusting agent is selected from acids (aicd) or bases (base), for example, hydrochloric acid, sulfuric acid, tartaric acid, citric acid, phosphoric acid, acetic acid, lactic acid, sodium lactate, sodium hydroxide, potassium hydroxide, alkyl amines, alkanes It may be selected from the group consisting of olamine and ammonia.

{Example}

Hereinafter, the present disclosure will be described in detail by examples. However, the following examples are only examples for helping the overall understanding of the present disclosure, and the content of the present disclosure is not limited to the following examples.

<Preparation Example> Preparation of shampoo composition for preventing hair loss or dandruff

A shampoo composition for preventing hair loss or dandruff was prepared according to the composition shown in Table 1 below (unit: % by weight).

division Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 evening primrose extract 0.0000025 - - 0.0000025 0.0000025 0.0000025 0.0000025 0.0000025 Kudzu Root Extract 0.0000025 - 0.0000025 - 0.0000025 0.0000025 0.0000025 0.0000025 Daewang Pine Leaf Extract 0.0000025 - 0.0000025 0.0000025 - 0.0000025 0.0000025 0.0000025 Sugar Elm Root Extract 0.0000025 - 0.0000025 0.0000025 0.0000025 - 0.0000025 0.0000025 zinc pyrithione 0.245 0.245 0.245 0.245 0.245 0.245 - 0.245 Piroctoneolamine 0.001 0.001 0.001 0.001 0.001 0.001 - 0.001 Climbazole 0.001 0.001 0.001 0.001 0.001 0.001 - 0.001 dexpanthenol 0.2 0.2 0.2 0.2 0.2 0.2 0.2 - salicylic acid 0.2 0.2 0.2 0.2 0.2 0.2 0.2 - Niacinamide 0.1 0.1 0.1 0.1 0.1 0.1 0.1 - Surfactants Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Spices Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Purified water balance balance balance balance balance balance balance balance

<Reference example> Experimental method

1. Subject selection

In order to confirm the anti-dandruff effect of the cosmetic composition for preventing hair loss or dandruff containing the crude drug extract of the present invention, 20 adult women with an average age of 51.3 years old who usually have dandruff on their scalp and feel itchy (one in their 30s and one in their 40s) 1 person, 13 people in their 40s, 1 person in their 60s) were applied to the scalp (forehead, crown, right head, left head) once a day for 4 weeks.

2. Statistical analysis

It was analyzed using a statistical analysis program (SPSS statistics), and the test results were subjected to statistical analysis after performing a normality test. As a result of the analysis, when the significance probability p<0.05 in the 95% confidence interval, it was judged that there was an improvement effect by using the test product. For statistical analysis, paired samples t-test was used in the case of using the parametric method, and Wilcoxon signed rank test was used in the case of using the non-parametric method.

<Experimental Example 1> Visual evaluation of dandruff information

The degree of dandruff of the subjects was judged by two or more experts according to the judgment criteria, and if there was a difference in the evaluations of the two experts, a level with low efficacy was adopted. At this time, the degree of dandruff was evaluated by the degree of dandruff attached to the hair away from the scalp and the degree of dandruff attached to the scalp. In principle, it was judged by observing the overall condition of the hair and scalp. The average was calculated by adding the values of dandruff attached to the hair and scalp. The lower the score of the degree of dandruff, the better the degree of dandruff. The values are shown in Table 2 below (9-10 points: very severe, 7-8 points: severe, 5-6 points: many, 3-4 points: severe, 1-2 points: slightly present, 0 points : none at all).

Example 1 Measurements (mean ± error) p-value improvement rate Before using the product 3.55 ± 1.172 - - After 2 weeks of product use 2.88 ± 0.740 0.000 15.4 After 4 weeks of product use 2.13 ± 0.415 0.000 40.1

From Table 2, it can be seen that the degree of dandruff is improved to a statistically significant level when the active ingredients of the composition according to the present invention are included in a preferred content range.

<Experimental Example 2> Dandruff severity evaluation

The test site was photographed before (0 weeks), 2 weeks after product use, and 4 weeks after product use using a high-resolution image capture device KONG Camera (Video Micro Scope, Bomtech). Measurement sites were performed on four parts of the scalp, including the forehead, crown, right temporal region, and left temporal region. The degree of dandruff relief by severity classification was evaluated through the photographed images. Scalp dandruff severity grade (Grade) is shown in Figure 1. 1 is a photograph showing the severity grade of scalp dandruff. The lower the scalp dandruff severity grade, the better the dandruff severity. The values are shown in Table 3 below. On the other hand, the scalp condition of each subject is shown in FIGS. 2 to 21. 2 to 21 are images of subjects' scalp conditions measured.

Example 1 Measurements (mean ± error) p-value improvement rate Before using the product 2.7 ± 0.558 - - After 2 weeks of product use 2.0 ± 0.406 0.000 23.7 After 4 weeks of product use 1.7±0.479 0.000 36.5

From Table 3, when the active ingredients of the composition according to the present invention are included in a preferred content range, it can be confirmed that the severity of dandruff is improved to a statistically significant level.

<Experimental Example 3> Evaluation of the amount of dandruff

Dandruff weight (g) was measured using a precision electronic scale (IZY-220) before product use (0 weeks), after 2 weeks of product use, and after 4 weeks of product use. Each subject combed their dandruff using a hair brush (a hard thing to brush their hair strongly) a total of 60 times (dividing their hair into three parts, left, center, and right, 20 times each). , and collected in polyvinylacetate plastic (20 x 30 inches, black). The weight of the collected dandruff was measured to evaluate the degree of dandruff improvement. The lower the weight, the better the amount of dandruff (unit: g). The values are shown in Table 4 below.

Example 1 Measurements (mean ± error) p-value improvement rate Before using the product 0.0251 ± 0.0110 - - After 2 weeks of product use 0.0199 ± 0.0078 0.000 19.4 After 4 weeks of product use 0.0141 ± 0.0079 0.000 44.3

From Table 4, it can be seen that the amount of dandruff is improved to a statistically significant level when the active ingredients of the composition according to the present invention are included in a preferred content range.

<Experimental Example 4> Evaluation of degree of itching

For each subject's self-assessment of itching, the change in itching score was evaluated before product use (0 weeks), after 2 weeks of product use, and after 4 weeks of product use. Itch The lower the score of the degree of itchiness, the better it means. The average values are shown in Table 2 below (4 points: very severe, 3 points: many, 2 points: severe, 1 point: slightly, 0 points: none). The values are shown in Table 5 below.

Example 1 Measured value (mean ± error) p-value improvement rate Before using the product 3.0 ± 0.826 - - After 2 weeks of product use 2.3±0.470 0.000 18.3 After 4 weeks of product use 1.0 ± 0.394 0.000 65.8

From Table 5, it can be seen that when the active ingredients of the composition according to the present invention are included in a preferred content range, the degree of itching is improved to a statistically significant level.

<Experimental Example 4> Adverse reaction evaluation

Erythema, edema, scaling, itching, stinging, burning, stiffness, prickling, and other abnormalities are evaluated with the naked eye. It was observed and evaluated whether a reaction occurred. As a result of the experiment, it was confirmed that there were no adverse reactions in all subjects.

<Experimental Example 6> Evaluation of usability and preference

For each subject, the usability and preference of the product was evaluated on a 5-point scale, and a positive response was considered when the score was 3 or higher. The average values are shown in Table 2 below (5 points: very much so, 4 points: so, 3 points: normal, 2 points: not so, 1 point: very not so). The average values are shown in Table 6 below.

division Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Dandruff and itching feeling improved 4.30 2.70 2.40 2.65 3.40 2.85 2.85 3.05 Moisture 4.25 2.60 2.55 2.60 2.90 2.90 3.00 3.05 lubricity 3.80 1.80 2.40 3.05 2.80 1.95 2.40 2.40 absorbent 4.60 2.85 2.85 3.45 3.40 2.90 3.00 3.00 spreadability 4.30 2.80 2.35 2.70 3.20 2.50 2.45 3.00 degree of incense 4.40 2.85 2.35 2.50 3.20 2.40 2.25 2.30 Overall usability 4.25 2.80 2.80 2.40 3.00 2.95 2.35 2.20

From Table 6, it can be seen that when the active ingredients of the composition according to the present invention are included in a preferred content range, the feeling of use is excellent.

Although the present invention has been described with respect to the preferred embodiments mentioned above, various modifications and variations are possible without departing from the spirit and scope of the invention. Accordingly, the appended claims are intended to include such modifications and variations insofar as they fall within the scope of the present invention.

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Claims (3)

It contains evening primrose extract, kudzu root extract, king pine leaf extract and sugar elm root extract as active ingredients,
Further comprising an antimicrobial agent which is a mixture of Zinc Pyrithione, Piroctone Olamine and Climbazole as an active ingredient,
It further contains a conditioning agent, which is a mixture of Dexpanthenol, Salicylic Acid and Niacinamide, as an active ingredient,
The content ratio of the evening primrose extract, kudzu root extract, king pine leaf extract, and sugar elm root extract is 1: 0.5 to 1.5: 0.5 to 1.5: 0.5 to 1.5 based on weight,
The content ratio of zinc pyrithione, piroctone olamine and climbazole is 1: 0.0025 to 0.0075: 0.0025 to 0.0075 based on weight,
The content ratio of Dexpanthenol, salicylic acid and niacinamide is 1: 0.5 to 1.5: 0.25 to 0.75 based on weight, a cosmetic composition for preventing hair loss or dandruff. delete delete