KR20110034265A - Capsule endoscope having biopsy function and method for controling the same - Google Patents

Abstract

PURPOSE: A capsule endoscope including a biopsy function and a control method thereof are provided to inspect tissues by detecting light of a specific wavelength band among Raman-scattered light. CONSTITUTION: A camera(100) photographs internal organs of an object. A laser diode(130) irradiates a laser beam to the tissue of the internal organs of the object. A detector(150) detects the light of a specific wavelength band among Raman-scattered light.

Description

Capsule endoscope having biopsy function and method for controling the same}

The present invention relates to a capsule endoscope having a biopsy function capable of examining tissue and a control method thereof.

In general, an endoscope is a medical apparatus used to diagnose or treat diseases in the human body, such as the esophagus, stomach, colon, small intestine, colon, rectum, and anus, without surgery.

The endoscope may be inserted through the oral cavity or the anus to cause pain in the subject according to the body cavity structure of the subject, and the degree of pain and the examination time vary depending on the technical skill of the endoscope operator.

Therefore, during endoscopy, pain and discomfort are not welcomed by the subjects. For example, in the case of colonoscopy, the pain suffered by the patient depends largely on the experience and skill of the operator. There is a situation.

This invention solves the subject which can test a tissue.

According to a preferred aspect of the present invention,

A camera for imaging the inside of the organ of the subject;

A laser diode for irradiating a laser beam to tissue inside the organ of the subject;

There is provided a capsule endoscope having a biopsy function configured to include a detector for detecting light of a specific wavelength band among Raman-scattered lights of the irradiated laser beam.

Another preferable aspect of this invention is that

Irradiating light into the organ of the subject under at least one light source;

Imaging the organ inside with a camera;

Irradiating a laser beam to the organ internal tissue with a laser diode;

Provided is a control method of a capsule endoscope having a biopsy function configured to include detecting a light having a specific wavelength band among Raman scattered light in the tissue.

Another preferred embodiment of the present invention,

Irradiating light into the organ of the subject under at least one light source;

Imaging the organ inside with a camera;

Analyzing whether the abnormality exists in the organ by analyzing the image photographed by the camera;

Irradiating a laser beam on the tissue of the abnormal site when the abnormal site exists in the organ;

Provided is a control method of a capsule endoscope having a biopsy function configured to detect a Raman scattered light having a specific wavelength among raman scattered light in the tissue of the abnormal site.

The capsule endoscope of the present invention close-ups the inside of a small organ such as the esophagus, the small intestine, or the large intestine of the subject, irradiates a laser beam to the tissue inside the organ, and detects light having a specific wavelength band among the light Raman scattered from the tissue. Since the detection unit detects a disease such as cancer by examining a tissue using Raman spectroscopy.

In addition, since the capsule endoscope of the present invention can perform a biopsy without performing a biopsy to cut out the tissue and examine the cut tissue, the subject does not have to feel pain due to the biopsy and is unnecessary such as anesthesia. There is no need to perform medical activities.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings.

1 is a schematic cross-sectional view for explaining a capsule endoscope having a biopsy function according to the present invention.

Capsule endoscope 300 of the present invention comprises a camera 100 for imaging the inside of the organ of the subject; A laser diode 130 for irradiating a laser beam to tissues inside the organ of the subject; It includes a detector 150 for detecting light of a specific wavelength band of the Raman-scattered light of the irradiated laser beam.

That is, the capsule endoscope of the present invention close-ups the inside of a small organ such as the esophagus, the small intestine, or the large intestine of the subject, irradiates a laser beam to the tissue inside the organ, Since light can be detected by the detection unit, a tissue such as cancer can be diagnosed by examining a tissue using Raman spectroscopy.

Herein, when the laser beam is irradiated, absorption, fluorescence, and scattering are generated in the tissue. The capsule endoscope of the present invention detects only a specific wavelength band of scattered light of the laser beam.

Therefore, the capsule endoscope of the present invention can perform a biopsy without performing a biopsy to cut out the tissue and examine the cut tissue, so that the subject does not have to feel pain due to the biopsy and is unnecessary such as anesthesia. There is an advantage in not having to perform medical activities.

On the other hand, to facilitate the imaging of the camera 100, at least one light source for irradiating light inside the organ is further provided.

Referring to FIG. 1, the capsule endoscope 300 irradiates light a1 and a2 to the inside of the organ from the first and second light sources 111 and 112, and captures the inside of the organ from the camera 100.

In addition, the laser diode 130 irradiates the laser beam b1 to the internal tissues of the organ, and detects the light b2 of a specific wavelength band among the light Raman scattered from the tissue by the detector 150.

In addition, the camera 100, the laser diode 130, the detector 150, and the light source may be installed at the tip of the capsule endoscope 300 in a direction in which the capsule endoscope 300 is advanced.

In addition, the capsule endoscope 300 may be provided with a driving unit that can move forward or backward along the organ of the subject.

2A to 2D are schematic cross-sectional views for explaining a method of controlling a capsule endoscope having a biopsy function according to the present invention.

First, when the capsule endoscope 300 reaches the organ of the subject after being swallowed from the mouth of the subject, the first and second light sources 111 and 112 irradiate light into the organ 200 (FIG. 2A).

After that, the inside of the organ 200 is captured by the camera 100. (FIG. 2B).

Subsequently, the laser diode 130 irradiates a laser beam to the internal tissues of the organ 200 (FIG. 2C).

Subsequently, the detector 150 detects light of a specific wavelength band among the Raman scattered light in the tissue (FIG. 2D).

At this time, the capsule endoscope of the present invention lights up the light source to irradiate the light, image it with a camera, turn off the light source, drive a laser diode to irradiate a laser beam, and detect a light having a specific wavelength band from the Raman scattered light at the detector. By stopping the driving of the laser beam after detection, the power consumption of the capsule endoscope can be reduced.

3 is a schematic cross-sectional view for explaining a detector according to the present invention.

The detector 150 detects light of a specific wavelength band among Raman-scattered lights of the irradiated laser beam.

To this end, the detector 150 includes a photodiode 151 and a wavelength filter 152 that transmits a specific wavelength band mounted on the photodiode 151.

That is, the Raman scattered light in the tissue irradiated with the laser beam reaches the wavelength filter 152 when incident to the detector 150. The Raman scattered light A1, A2, and A3 reaching the wavelength filter 152 transmits only the light A2 of the allowable wavelength band transmitted by the wavelength filter 152 and enters the photodiode 151.

As a result, the photodiode 151 can detect only the light A2 of a specific wavelength band.

Therefore, the capsule endoscope of the present invention does not need a diffraction grating for spectroscopy by applying a wavelength filter to detect light of a specific wavelength band.

Figure 4 is a schematic cross-sectional view for explaining another embodiment of a capsule endoscope having a biopsy function according to the present invention.

The capsule endoscope 300 captures the inside of the organ 200 by the camera 100 while moving along the organ 200.

In addition, when the image captured by the camera 100 is analyzed by an external device, and the abnormal portion 210 is present inside the organ 200 in the result analyzed by the external device, the capsule endoscope 300 You can examine the tissue at the site.

Such a tissue test irradiates a laser beam from the laser diode 130 to the tissue of the abnormal region 210, detects light of a specific wavelength band among the Raman scattered light from the tissue, and then detects the light in the detector 150. 150 may be used to diagnose diseases such as cancer by examining tissues with signals for Raman scattered light.

In this case, the capsule endoscope 300 continuously moves along the organ 200 ('B' direction). When the laser diode 130 and the detector 150 are positioned at the front end of the capsule endoscope 300, In addition, the laser beam may not be irradiated onto the tissue of the abnormal region 210 and may not detect the Raman scattered light.

That is, as the capsule endoscope 300 moves, the abnormal part 210 is out of the laser beam irradiation area of the laser diode 130 and the detection area of the detection unit 150.

Therefore, the capsule endoscope of this embodiment is installed on the side of the capsule endoscope 300 and the laser diode 130 and the detection unit 150, even if the capsule endoscope 300 is moved in the tissue of the abnormal site 210 Raman scattered light can be detected.

5A and 5B are schematic cross-sectional views for explaining the backward function of a capsule endoscope having a biopsy function according to the present invention.

As described above with reference to FIG. 4, even when the laser diode 130 and the detection unit 150 are installed on the side of the capsule endoscope 300, the capsule endoscope 300 is excessively moved in the tissue of the abnormal part 210. Raman scattered light cannot be detected.

Therefore, it is preferable that the capsule endoscope of the present invention is provided with an active locomotion control unit such as a driving unit capable of reversing.

That is, as shown in Figure 5a, the capsule endoscope 300 is moved along the organ 200, when excessively over the abnormal portion 210, the operation of the drive unit that can advance the capsule endoscope 300 The capsule endoscope is operated such that the abnormal part 210 is positioned in the laser beam irradiation area of the laser diode 130 and the detection area of the detection unit 150 by operating the driving unit capable of stopping and reversing. Reverse 300.

Here, the capsule endoscope 300 is retracted from the position (L) of Figure 5a is adjusted to the position of Figure 5b.

Thereafter, the laser diode 130 and the detection unit 150 can smoothly perform an operation of detecting light of a specific wavelength band among the Raman scattered light in the tissue of the abnormal region 210.

6 is a schematic cross-sectional view for explaining another embodiment of a capsule endoscope having a biopsy function according to the present invention.

In the capsule endoscope of this embodiment, the light sources 121 and 122 and the camera 101 are further provided on the side surfaces of the capsule endoscope.

That is, when the capsule endoscope moves (forwards driving) the organ and confirms the abnormal site by the captured image, before the laser is irradiated to the tissue of the abnormal site, the light sources 121 and 122 and the camera ( By using 101), the abnormal part may be imaged again, and the captured image may be analyzed to reconfirm whether the abnormal part is a normal part.

After performing such a reconfirmation operation, if the abnormal site is confirmed, the laser beam is irradiated from the laser 130 installed at the side of the capsule endoscope, and the detector 150 detects the Raman scattered light to examine the tissue.

Therefore, in the present invention, the presence of the abnormality is primarily determined by the image C1 captured by the camera 100 installed at the tip of the capsule endoscope in the direction in which the capsule endoscope is advanced.

After that, the presence of the abnormal part is determined second by the image C2 captured by the camera 101 installed on the side of the capsule endoscope.

7 is a block diagram of a capsule endoscope having a biopsy function according to the present invention.

Capsule endoscope 300 of the present invention comprises at least one light source 310 for irradiating light inside the organ of the subject; A camera (100) for capturing the inside of the organ; A laser diode (130) for irradiating a laser beam to tissues in the organ; And a detector 150 for detecting light of a specific wavelength band among Raman-scattered lights of the irradiated laser beam.

The light source 310, the camera 100, the laser diode 130, and the detector 150 are driven under the control of the controller 350.

That is, the controller 350 controls the capsule endoscope 300 to be smoothly driven inside the organ of the subject.

In addition, the capsule endoscope of the present invention may include a built-in power source such as a battery for driving, or may be driven by an external magnetic field.

8 is another block diagram of a capsule endoscope having a biopsy function according to the present invention.

The capsule endoscope further includes an RF transmitter 360 capable of performing wireless communication with an RF receiver of an external device 500 that is external to the subject.

In addition, the controller 350 outputs an image signal captured by the camera 320 and a signal for Raman scattered light having a specific wavelength band detected by the detector 150 to the RF transmitter 360.

The RF transmitter 360 is an RF receiver 510 of the external device 500 for the RF of the image signal captured by the camera 320 and the Raman scattered light of a specific wavelength band detected by the detector 150. Transmit the RF of the signal.

The external device 500 determines whether there is an abnormal part inside the organ of the subject from the RF of the image signal captured by the camera 320 received by the RF transmitter 360, and the detection unit ( The peak of the Raman scattered light of a specific wavelength band from the RF of the signal for the Raman scattered light of the specific wavelength band detected by 150 determines whether a disease such as cancer exists in the tissue.

Here, the external device 500 includes an image signal, a Raman scattered light analysis function, and a memory function.

9 is a block diagram illustrating a position sensor is provided in the capsule endoscope having a biopsy function according to the present invention.

As the capsule endoscope moves inside the organ of the subject, it continuously captures an internal image and detects Raman scattered light of the laser beam in the tissue of the abnormal site.

At this time, it is necessary to recognize which part of the organ the image is captured, and knowing whether the detected Raman scattered light is the tissue of the frozen part of the organ, it is possible to diagnose the disease of the correct part.

However, the picked-up image does not know which part of the organ was picked up, and the detected Raman scattered light does not indicate which part of the organ is Raman scattered light detected in the tissue.

Therefore, the present invention preferably includes a position sensor 370 capable of detecting a position when the capsule endoscope is moved.

The position sensor 370 detects a change in position as the capsule endoscope moves, and preferably includes a gyro sensor and / or an acceleration sensor.

Next, a control method of a capsule endoscope equipped with a position sensor will be described.

First, the position detection sensor 370 provided in the capsule endoscope 370 detects the position of the capsule endoscope 370, outputs a signal for the position of the capsule endoscope 370 to the control unit 350, and controls the control unit ( 350 outputs a signal for the position of the capsule endoscope 370 to the RF transmitter 360.

Thereafter, the RF transmitter 360 performs RF (S1) of the image signal captured by the camera 320, RF (S2) of the signal for the Raman scattered light of a specific wavelength band detected by the detector 150, and the capsule endoscope ( The RF (S3) of the signal for the position of the 370 is transmitted to the RF receiver 510 of the external device 500.

Therefore, the external device 500 can recognize the position of the capsule endoscope 370 by the RF (S3) of the signal for the position of the capsule endoscope 370 received by the RF receiver 510.

10 is a block diagram illustrating the configuration of a position sensor in an external device according to the present invention.

The external device 500 may be provided with a sensor capable of sensing the position of the capsule endoscope 300. When the sensor does not exist in the capsule endoscope 300, the RF transmitter 360 may include a camera. Only RF (S1) of the image signal captured by the 320 and the RF (S2) of the signal for the Raman scattered light of a specific wavelength band detected by the detector 150 are transmitted to the RF receiver 510 of the external device 500. do.

In addition, the external device 500 is responsible for detecting the position of the capsule endoscope 300.

As such, the configuration and method for detecting the position of the capsule endoscope 300 in the external device 500 may be applied in various ways, for example, position detection by triangulation.

That is, referring to FIG. 11, a plurality of RF receiving antennas 511, 512, 513, 514, 515, 516, 517, 518 and 519 are attached to the skin of the subject 600. At this time, the shape consisting of three antennas should be a triangle.

The plurality of RF receiving antennas 511, 512, 513, 514, 515, 516, 517, 518 and 519 are included in an RF receiver of an external device.

FIG. 11 illustrates that nine RF receiving antennas are attached to the skin of the subject 600. The first and ninth RF receiving antennas 511,512,513,514,515,516,517,518,519 are attached to the skin of the subject 600, The shape of the antennas is triangular.

In this case, when the capsule endoscope is moved into the organ of the subject 600, when the RF of the image signal photographing the organ and the RF of the Raman scattering light are detected in the tissue, the first and ninth RF receptions are received. Each of the antennas 511, 512, 513, 514, 515, 516, 517, 518, and 519 detects the RF of an image signal captured inside the organ and the RF of a signal for detecting Raman scattered light in the tissue.

When the intensity of the RF detected by each of the first and ninth RF receiving antennas 511, 512, 513, 514, 515, 516, 517, 518 and 519 is high, the second receiving antenna 512, the third receiving antenna 513 and the fifth receiving antenna 515 are encapsulated. The endoscope is determined to exist within a triangle composed of the second receiving antenna 512, the third receiving antenna 513, and the fifth receiving antenna 515.

The second receiving antenna 512, the third receiving antenna 513, and the third receiving antenna 513 and the fifth receiving antenna 515 respectively have the second receiving antenna 512 and the third receiving antenna 513 according to the reception strength of RF. ) And the equivalent position detection parameters, such as distance and the like at the fifth receiving antenna 515, may determine the position of the capsule endoscope.

12A and 12B are pulse waveform diagrams applied to a light source and a laser diode applied according to the present invention.

12A is a pulse waveform diagram applied to a light emitting diode (LED) light source, which is lit from a sinusoidal pulse K1, and FIG. 12B is a pulse waveform diagram applied to a laser diode, and a 'K2' sinusoidal pulse between 'K1' sinusoidal pulses. Is positioned to light the laser diode.

Therefore, the light source and the laser diode can be designed to light sequentially in order to reduce power consumption.

13 is a graph illustrating a method of diagnosing a disease with Raman scattered light detected by a single detection unit according to the present invention.

The laser beam irradiated from the laser diode is Raman scattered from the tissue of the organ of the subject, and only the light of a specific wavelength band of the Raman scattered light is detected by the detector.

In this case, the detector may be configured of a single or a plurality of detectors, and only a peak of a single wavelength band is detected by the single detector.

As described above, since the detection unit is preferably composed of a wavelength filter and a photodiode, when the allowable wavelength band transmitted by the wavelength filter is 'D1' peak in FIG. 13, Raman scattered light having a peak of 'D3' is detected. If it is, the presence of the disease is determined by comparing the detected peak of Raman scattered light 'D3' and the normal tissue Raman scattered light 'D2'.

On the other hand, the capsule endoscope having a biopsy function of the present invention can select the wavelength filter of the detector in the wavelength band where the spectral difference between the Raman scattered light of healthy tissue and cancer tissue is generated a lot.

That is, since the wavelength band where the spectral difference between the Raman scattered light of healthy tissue and cancer tissue is large is 843 nm, 867 nm, 886 nm, and 902 nm, the wavelength filter of the detection unit is 843 nm, 867 nm, 886 nm, and 902 nm. It is preferable to apply to the wavelength filter which transmits the Raman scattered light of one wavelength band.

14 is a schematic diagram illustrating a capsule endoscope having a plurality of detection units according to the present invention.

In order to examine the tissue of the abnormal part 210 in the organ 200 of the subject, as described above, the tissue of the abnormal part 210 is irradiated with a laser beam and the Raman scattered light from the tissue is detected by the detector. Detect.

The detector may be configured in plural, and as illustrated in FIG. 14, the first to fourth detectors 151a and 152a, 151b and 152b, 151c and 152c and 151d around the laser diode 130. 152d)) are arranged.

Each of the first to fourth detectors 151a, 152a, 151b, 152b, 151c, 152c, and 151d, 152d is provided with wavelength filters 151a, 151b, 151c and 151d. The wavelength filters 151a, 151b, 151c, and 151d have different allowable wavelength bands for transmitting Raman scattered light.

That is, the wavelength filters 151a, 151b, 151c, and 151d transmit Raman scattered light having different wavelength bands.

15 is a graph for explaining a method of diagnosing a disease with Raman scattered light detected by a plurality of detection units according to the present invention.

As shown in FIG. 14, the allowable wavelength band through which the Raman scattered light is transmitted is set differently, as shown in FIG. 15. As illustrated in FIG. 15, the first detector may detect a first wavelength λ1 band such as a peak of 'D1a'. The second detector may detect a second wavelength lambda 2 band, such as the 'D1b' peak, and the third detector may detect a third wavelength lambda 3 band, such as the 'D1c' peak.

Therefore, when the Raman scattered light having the peak of 'D3a' is detected in the first detector, the detected Raman scattered light is compared with the peak of the detected Raman scattered light 'D3a' and the peak 'D2a' of the normal Raman scattered light, and the second detector detects the Raman scattered light. D3b, the peak of Raman scattered light, and D2b, the peak of Raman scattered light of normal tissue, and D3c, the peak of Raman scattered light detected by the third detector, and D2c of Raman scattered light of normal tissue, After comparison, the presence or absence of the disease may be more accurately determined by comparing the peaks D3a ',' D3b ', and' D3c 'detected by the first to third detection units.

That is, the capsule endoscope of the present invention is capable of diagnosing a disease at the ratio of detected scattering intensity or scattering intensity.

16 is a flowchart illustrating a control method of a capsule endoscope having a biopsy function according to the present invention.

When the capsule endoscope reaches the organ of the subject, the light source is turned on (step S110), and the camera captures the inside of the organ (step S120).

Thereafter, the laser beam is irradiated from the laser to the organ (step S130), and the Raman scattered light is detected from the organ to which the laser beam is irradiated (step S140).

As such, the capsule endoscope repeatedly performs a series of steps consisting of '110', '120', '130' and '140' in the organ.

Meanwhile, after performing a series of steps consisting of steps 110, 120, 130, and 140, the RF of the image signal captured by the camera and a specific wavelength band detected by the detector are performed. The RF of the signal for the Raman scattered light may be further performed by the RF transmitter to the RF receiver of the external device.

And the capsule endoscope, as shown in Figure 17, can examine the tissue of the abnormal site in the organ.

First, when the capsule endoscope reaches the organ of the subject, the light source is turned on (step S210), and the camera captures the inside of the organ (step S220).

Next, the image captured by the camera is analyzed to determine whether an abnormal part exists in the organ (step S230).

Here, the determination of whether there is an abnormal part in the organ may be performed by the controller of the capsule endoscope or by an external device.

Subsequently, when an abnormal site exists in the organ, the laser beam is irradiated to the tissue of the abnormal site (step S240).

Subsequently, the detection unit detects Raman scattered light having a specific wavelength among the Raman scattered light in the tissue of the abnormal site.

It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

1 is a schematic cross-sectional view for explaining a capsule endoscope having a biopsy function according to the present invention

Figure 2a to 2d is a schematic cross-sectional view for explaining the control method of the capsule endoscope having a biopsy function according to the present invention

3 is a schematic cross-sectional view for explaining a detector according to the present invention.

Figure 4 is a schematic cross-sectional view for explaining another embodiment of a capsule endoscope having a biopsy function according to the present invention

5a and 5b are schematic cross-sectional views for explaining the reverse function of the capsule endoscope having a biopsy function according to the present invention

Figure 6 is a schematic cross-sectional view for explaining another embodiment of a capsule endoscope having a biopsy function according to the present invention

Figure 7 is a block diagram of a capsule endoscope having a biopsy function according to the present invention

8 is another block diagram of a capsule endoscope having a biopsy function according to the present invention

9 is a block diagram illustrating a position sensor is provided in the capsule endoscope having a biopsy function according to the present invention

10 is a block diagram illustrating the configuration of a position sensor in an external device according to the present invention.

11 is a diagram schematically illustrating a state in which RF receiving antennas are attached to the skin of a subject according to the present invention.

12A and 12B are pulse waveform diagrams applied to a light source and a laser diode applied according to the present invention.

13 is a graph illustrating a method for diagnosing a disease with Raman scattered light detected by a single detector according to the present invention.

14 is a schematic diagram illustrating a capsule endoscope having a plurality of detection units according to the present invention.

15 is a graph illustrating a method of diagnosing a disease with Raman scattered light detected by a plurality of detection units according to the present invention.

16 is a flowchart illustrating a control method of a capsule endoscope having a biopsy function according to the present invention.

17 is another flow chart for explaining the control method of the capsule endoscope having a biopsy function according to the present invention

Claims (20)

A camera for imaging the inside of the organ of the subject; A laser diode for irradiating a laser beam to tissue inside the organ of the subject; Capsule endoscope having a biopsy function comprising a detector (Detector) for detecting light of a specific wavelength band of the Raman-scattered light of the irradiated laser beam. The method according to claim 1, The detection unit, A photodiode; And a wavelength filter mounted on the photodiode and configured to transmit a specific wavelength band among the Raman scattered light beams of the irradiated laser beam. The method according to claim 2, The detection unit is a plurality, The wavelength filter of each of the detection units, Capsule endoscope having a biopsy function, characterized in that the wavelength band for transmitting the Raman scattered light is different. The method according to claim 1, Capsule endoscope having a biopsy function, characterized in that further provided with at least one light source for irradiating light inside the organ. The method according to claim 4, The camera, the laser diode, the detection unit and the light source, Capsule endoscope having a biopsy function, characterized in that the capsule endoscope is installed at the leading end of the capsule endoscope in the forward direction. The method according to claim 1, The capsule endoscope, Capsule endoscope having a biopsy function characterized in that it further comprises a drive unit capable of moving forward or backward along the organ. The method according to claim 4, The camera and the light source are installed at the tip of the capsule endoscope in the direction in which the capsule endoscope advances, The capsule endoscope having a biopsy function, characterized in that the laser diode and the detection unit is formed on the side of the capsule endoscope. The method of claim 7, Side of the capsule endoscope capsule endoscope having a biopsy function, characterized in that the camera is further provided with another light source. The method according to claim 4, Capsule endoscope having a biopsy function, characterized in that further comprising a control unit for controlling the camera, the laser diode, the detection unit and the light source. The method according to claim 9, Capsule endoscope having a biopsy function further comprises an RF transmitter for performing wireless communication with an RF receiver of an external device external to the subject. The method according to claim 10, The control unit, Outputting an image signal captured by the camera and a signal for Raman scattered light of a specific wavelength band detected by the detector to the RF transmitter; The RF transmitter has a biopsy function, characterized in that configured to transmit the RF of the image signal captured by the camera and the RF of the signal for the Raman scattered light of a specific wavelength band detected by the detector to the RF receiver of the external device. Capsule endoscope. The method according to claim 9, A capsule endoscope having a biopsy function is further provided with a position detecting sensor capable of detecting a position of the capsule endoscope, wherein the controller controls the position detecting sensor. The method according to claim 12, The control unit, Outputs an image signal captured by the camera, a signal for Raman scattered light of a specific wavelength band detected by the detector, and a signal for the position of the capsule endoscope detected by the position sensor to the RF transmitter; The RF transmitter transmits an RF of an image signal captured by the camera, an RF of a signal for Raman scattered light of a specific wavelength band detected by the detector, and an RF of a signal of a position of the capsule endoscope to an RF receiver of the external device. Capsule endoscope having a biopsy function, characterized in that configured to. The method of claim 11, RF receiver of the external device, Capsule endoscope having a biopsy function, characterized in that it comprises a plurality of RF receiving antennas attached to the shape of the three antennas on the skin of the subject to be a triangle. Irradiating light into the organ of the subject under at least one light source; Imaging the organ inside with a camera; Irradiating a laser beam to the organ internal tissue with a laser diode; The method of controlling the capsule endoscope having a biopsy function comprising the step of detecting the light of a specific wavelength band of the Raman scattered light in the tissue. Irradiating light into the organ of the subject under at least one light source; Imaging the organ inside with a camera; Analyzing whether the abnormality exists in the organ by analyzing the image photographed by the camera; Irradiating a laser beam on the tissue of the abnormal site when the abnormal site exists in the organ; The method of controlling the capsule endoscope having a biopsy function comprising the step of detecting the Raman scattered light of a specific wavelength of the Raman scattered light in the tissue of the abnormal site. 18. The method of claim 16, The camera and light source, The capsule endoscope is installed at the tip of the capsule endoscope in a forward direction, The side of the capsule endoscope is provided with a different light source and a different camera, In the analyzing of the image taken by the camera to determine whether there is an abnormal part in the organ, Re-imaging the abnormal site with a different camera from the other light source installed on the side of the capsule endoscope, and the step of analyzing the captured image and reconfirming whether the abnormal site or the normal site, characterized in that it has a biopsy function Control method of capsule endoscope. 18. The method of claim 16, Between analyzing the image taken by the camera to determine whether there is an abnormal site in the organ and, if there is an abnormal site in the organ, irradiating a laser beam to the tissue of the abnormal site with a laser, And transmitting an RF of an image signal captured by the camera and an RF of a signal for a Raman scattered light of a specific wavelength band detected by the detector to an RF receiver of an external device. Control method of capsule endoscope having a. 19. The method of claim 18, The RF transmitter, Capsule endoscope having a biopsy function, characterized in that further transmitting the RF of the signal for the position of the capsule endoscope to the RF receiver. 18. The method of claim 16, In the step of analyzing whether the abnormal part exists in the organ by analyzing the image photographed by the camera, when the abnormal part exists in the organ, the abnormality is detected in the laser beam irradiation area of the laser diode and the detection area of the detection unit. After the capsule endoscope is reversed so that the site is located, the method of controlling the capsule endoscope having a biopsy function, characterized by performing a step of irradiating a laser beam to the tissue of the abnormal site.

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