KR102323528B1 - Micro-needle patch and micro-needle system - Google Patents

Abstract

The present invention relates to a microneedle patch and a microneedle system. The microneedle patch according to an embodiment of the present invention is individualized from each other, a plurality of microneedles having an upper end and a base portion, and a water-soluble base layer that is bonded to the plurality of microneedles to two-dimensionally arrange the plurality of microneedles Including, when moisture is supplied to the water-soluble base layer when applied to the skin, the water-soluble base layer is removed so that the two-dimensionally arranged plurality of microneedles can be individualized. The water-soluble base layer may have a mesh structure formed by intersecting a plurality of linear portions, and the microneedles may be disposed in a region where the plurality of linear portions cross each other, and decomposition of the material of the water-soluble base layer for moisture Alternatively, the dissolution rate may be faster than the decomposition or dissolution rate of the material of the microneedle with respect to moisture.

Description

Micro-needle patch and micro-needle system

The present invention relates to a pharmaceutical, medical or cosmetic material delivery device, and more particularly, to a micro-needle patch and a micro-needle system.

As a method for delivering a pharmaceutical, medical or cosmetically effective substance applied to the human body to the human body, a method of injecting the active substance in a liquid form through a hypodermic injection needle is widely applied. However, a hypodermic injection needle having a diameter of several millimeters or less may stimulate a number of pain points existing in the skin and give pain to the patient, and there is a problem that requires a high level of skill for its use.

Recently, in order to overcome the above disadvantages of the hypodermic needle, a method for transdermal delivery of the active substance using a microneedle having a diameter and height of only tens or hundreds of μm has been actively studied. The microneedle can form numerous microchannels at once that penetrate the stratum corneum layer of the skin, which is the main barrier layer for transdermal drug delivery. to reach the dermis layer. Thereafter, the active substance may be absorbed through, for example, blood vessels and lymph glands and introduced into the circulatory system of the human body.

Microneedles are used for detection of analytes in the body or biopsy, in addition to delivering active substances such as drugs, vitamins, or vaccines in vivo. The microneedles were conventionally manufactured using silicone, non-biodegradable polymer, metal or glass as a material. However, the materials have a problem in that it takes a long time to diffuse in the body in a sufficient amount for the effects of the active substances to appear.

In addition, in order for the active substances to be accurately diffused and delivered into the body, the microneedle or the patch on which the microneedle is formed must be properly attached to a biological surface such as skin, and the microneedle inserted into the biological surface is stable for an appropriate time. should be maintained as However, in general, in the microneedle patch, the uniform adhesion state with the biological surface over the entire or partial area is broken by the bending of the biological surface or the movement of the biological surface muscle, and the microneedle in the area detached from the biological surface can be separated from the skin. In this case, in the detached region, the mass transfer effect cannot be obtained because the effective material is not sufficiently transferred by the microneedle of the corresponding part, or the active material is transferred to the periphery other than the target location, which may cause unwanted side effects. have.

(Patent Document 1) KR 2018-0134744 A

The problem to be solved by the present invention is to provide a microneedle patch capable of stably maintaining the self-grained state of the microneedle in the biological surface so that effective substances can be effectively delivered despite the curved biological surface or muscle movement of the biological surface will do

Another object to be solved by the present invention is to provide a microneedle system that can maintain the microneedle's self-injection state in the skin in an easy way and is easy to use.

A microneedle patch according to an embodiment of the present invention for solving the above problems is individualized from each other, a plurality of microneedles having an upper end and a base portion and a plurality of microneedles are bonded to the plurality of microneedles to make the plurality of microneedles two-dimensional It includes a water-soluble basal layer arranged in a systematic manner, and when moisture is supplied to the water-soluble basal layer when applied to the skin, the water-soluble basal layer is removed so that the two-dimensionally arranged plurality of microneedles can be individualized.

In one embodiment, the plurality of microneedles may be formed of a biodegradable material. In another embodiment, a keratolytic material may be coated on the plurality of microneedles.

In one embodiment, the water-soluble base layer may include a planar structure having a continuous surface, a mesh structure, a through hole structure, a nonwoven structure or a porous structure. In another embodiment, the water-soluble base layer may include a material that absorbs heat when dissolved.

A microneedle patch according to an embodiment of the present invention for solving the above problems is individualized from each other, a plurality of microneedles having an upper end and a base portion, and a plurality of microneedles are bonded to the plurality of microneedles to make the plurality of microneedles two-dimensional The water-soluble base layer may include a water-soluble base layer arranged in a systematic manner, and a moisture supply member for individualizing the two-dimensionally arranged plurality of microneedles by supplying moisture to the water-soluble base layer to remove the water-soluble base layer. In another embodiment, the water-soluble base layer may include a plurality of through-pores serving as a movement path through which substances included in the moisture supply member move to the skin.

In one embodiment, the moisture supply member may be a moisture-containing sheet, hydrogel sheet, mask pack, moisture gel, moisture cream, skin, essence, toner, or a combination thereof. In another embodiment, the moisture supply member may include a pharmaceutical, medical, or cosmetically active substance. In another embodiment, the microneedles may be decomposed inside the skin and penetrate a part of the skin to form a substance exchange channel between the skin and the moisture supply member.

The microneedle patch according to an embodiment of the present invention uses a water-soluble base layer to fix a plurality of microneedles, so that when moisture is supplied to the water-soluble base layer, the water-soluble base layer is decomposed and the microneedles are fixed. They can be easily separated from the water-soluble base layer and inserted into the skin, and when the water-soluble base layer is detached, the microneedles are prevented from escaping to the outside of the skin along the water-soluble base layer, resulting in high-efficiency medical or cosmetic effect can be achieved.

The microneedle system according to an embodiment of the present invention supplies a sufficient amount of moisture to the water-soluble base layer without additional effort by providing a moisture supply member containing sufficient moisture for decomposition of the water-soluble base layer. The base layer can be removed without residue. In addition, the microneedles are inserted into the skin and decomposed to form a material movement path, so that moisture and/or nutrients contained in the moisture supply member can be effectively absorbed into the skin through the material movement path.

Figure 1a is a view showing a microneedle patch according to an embodiment of the present invention, Figure 1b is a view showing a microneedle according to an embodiment of the present invention.
Figure 2 is a view showing a method of action of the microneedle patch according to an embodiment of the present invention.
Figures 3a to 3c is a view showing a microneedle patch according to various embodiments of the present invention.
4 is a view showing a microneedle system according to an embodiment of the present invention.
5 is a view showing a method of applying a microneedle system according to an embodiment.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

Examples of the present invention are provided to more completely explain the present invention to those of ordinary skill in the art, and the following examples may be modified in various other forms, and the scope of the present invention is as follows It is not limited to an Example. Rather, these examples are provided so that this disclosure will be more thorough and complete, and will fully convey the spirit of the invention to those skilled in the art.

In addition, in the drawings, the thickness or size of each layer is exaggerated for convenience and clarity of description, and the same reference numerals in the drawings refer to the same elements. As used herein, the term “and/or” includes any one and any combination of one or more of those listed items.

The terminology used herein is used to describe specific embodiments, not to limit the present invention. As used herein, the singular forms may include the plural forms unless the context clearly dictates otherwise. Also, as used herein, “comprise” and/or “comprising” refers to the presence of the recited shapes, numbers, steps, actions, members, elements, and/or groups of those specified. and does not exclude the presence or addition of one or more other shapes, numbers, movements, members, elements and/or groups.

Although the terms first, second, etc. are used herein to describe various members, parts, regions, and/or parts, these members, parts, regions, and/or parts should not be limited by these terms. is self-evident These terms are used only to distinguish one member, component, region or part from another region or part. Accordingly, a first member, component, region, or portion discussed below may refer to a second member, component, region or portion without departing from the teachings of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention are described with reference to the drawings which schematically show ideal embodiments of the present invention. In the drawings, for example, the size and shape of the members may be exaggerated for convenience and clarity of description, and in actual implementation, variations of the illustrated shape may be expected. Accordingly, embodiments of the present invention should not be construed as limited to the specific shapes of the members or regions shown herein.

Figure 1a is a perspective view of the microneedle patch 100 according to an embodiment of the present invention, Figure 1b is a view showing the microneedle 110 according to an embodiment of the present invention.

Referring to FIG. 1A , in one embodiment, the microneedle patch 100 may include a plurality of microneedles 110 , and a water-soluble base layer 120 supporting the plurality of microneedles 110 . have. The microneedles 110 are arranged on the water-soluble basal layer 120 extending in the first direction (x) and the second direction (y), and in the first direction (x) and/or the second direction (y). It is possible to form a microneedle array arranged spaced apart by a predetermined distance. In an embodiment, the predetermined distance may be in the range of 100 μm to 10 mm. The water-soluble base layer 120 may have a plate shape having both surfaces 120S1 and 120S2, and a plurality of microneedles 110 on the first surface 120S1 of the both surfaces 120S1 and 120S2 are formed in the third direction (z). ) can be arranged two-dimensionally. The term “two-dimensionally arranged” means that the plurality of microneedles 110 are formed on the first surface 120S1 of the water-soluble base layer 120 or the second surface 120S2 that is opposite to the first surface 120S1. It may mean that the surface is arranged to form a surface. In this case, the plurality of microneedles 110 may form a microneedle layer on the water-soluble base layer 120 .

Referring to FIG. 1B , in one embodiment, the microneedle 110 may have an upper end 112 and a base 111 . The base 111 of the microneedle 110 is a portion bonded to the base layer 120 , and the upper end 112 is a fore-end when the microneedle is incorporated into the living body surface. In one embodiment, the microneedle 110 may have a narrower diameter toward the upper end 112 from the base 111 . For example, the microneedle 110 may be conical as shown in FIG. 1B , the upper end 112 may be a tip, and the bottom surface of the base 111 may be a flat portion. The cross-section of the microneedle 110 is not limited to a circular shape, and may be a polygon, such as a triangle, a square, or a pentagon, or a combination thereof. In another embodiment, a portion of the microneedle 110 on the side of the base 111 is in the form of a column with a constant diameter, and a portion of the upper end 112 is a polygonal pyramid such as a cone, triangular pyramid or quadrangular pyramid extending from the column shape or these can have a combination of In another embodiment, the microneedle may have a columnar shape with a constant diameter from the base 111 to the upper end 112 . In one embodiment of the present invention, when the upper end 112 includes a tip, when the microneedle patch 100 is attached to the target site, the tip is such that the microneedle 110 can be easily inserted into the living body surface. And, as will be described later, the pharmacologically, medically or cosmetically effective material contained in at least a partial region of the microneedle 110 is easily formed through the channel in the living skin formed by the microneedle 110 in the dermis or body. It is possible to provide the microneedle patch 100 that can be introduced into the effective material can be efficiently delivered.

In one embodiment, the plurality of microneedles 110 may include a biodegradable material. The biodegradable material may be a monosaccharide, a polysaccharide, a biodegradable hydrogel, a biodegradable polymer, or a combination thereof. For example, the biodegradable material is chitosan, collagen, gelatin, hyaluronic acid (HA), alginic acid, pectin, carrageenan, chondroitin (sulfate), dextran (sulfate) , polylysine (polylysine), carboxymethyl titin, fibrin, agarose, pullulan, and at least any one of a bio-derived soluble substance of cellulose; polyvinylpyrrolidone (PVP); Polyethylene glycol (PEG), polyvinyl alcohol (PVA), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), hydroxypropyl methyl cellulose (HPMC), sodium carboxymethyl cellulose, polyalcohol, gum arabic, Alginate, cyclodextrin, dextrin, glucose, fructose, starch, trehalose, glucose, maltose, lactose, lactulose, fructose, turanose, melitose, melezitose, dextran, sorbitol, xylitol, palaty a biomaterial which is at least one of nits, polylactic acid, polyglycolic acid, polyethylene oxide, polyacrylic acid, polyacrylamide, polymethacrylic acid, and polymaleic acid; It may be a derivative of the above-mentioned substance or a mixture thereof. The above-mentioned materials are non-limiting examples, and embodiments of the present invention are not limited thereto, and all kinds of materials that are harmless to a living body and can be naturally decomposed in a living body may be applied. According to an embodiment of the present invention, since the materials constituting the plurality of microneedles 110 are biodegraded, there is an advantage that there is no need to take out the microneedles 110 outside the body after use.

In another embodiment, the plurality of microneedles 110 may be formed of hyaluronic acid. The hyaluronic acid is a biosynthetic material present in a large amount in the body, and has a moisturizing effect when applied to the skin, so it can be used as a cosmetic or a mask pack. According to an embodiment of the present invention, since the plurality of microneedles 110 are formed of hyaluronic acid, the microneedle 110 is self-injected into the skin tissue to moisturize even without providing a separate active material in the microneedle 110 . It is possible to obtain a significant moisturizing effect and/or a cosmetic effect by the moisturizing effect without an instrument such as an injection needle that causes pain while inducing the effect.

In another embodiment, the plurality of microneedles 110 may be formed of a water-soluble material, and the decomposition rate of the plurality of microneedles 110 by water is higher than the decomposition rate by water of the water-soluble base layer 120 . can be small Accordingly, the water-soluble base layer 120 is decomposed so that the plurality of microneedles 110 are first inserted into the skin to release the active substance, or the plurality of microneedles 110 are decomposed to generate a predetermined effect. The plurality of micro-needles 110 may be fixedly supported without being removed, and then, the water-soluble base layer 120 may be decomposed.

In another embodiment, the base 111 of the microneedle 110 may be formed of a water-soluble material, and the upper end 112 of the microneedle 110 may include an active material. In this case, the base 111 is dissolved so that the microneedles 110 can be easily separated from the water-soluble base 111 , and the upper end 112 is not limited to a material that can be separated from the water-soluble base layer 120 . Instead, the multifunctional microneedle patch 100 may be provided by being formed of a variety of effective materials that are the same as or different from the base portion 111 .

In one embodiment, a pharmaceutical, medical, or cosmetically effective substance may be dissolved, dispersed, or coated on the plurality of microneedles 110 . For example, the active substance may include, but is not limited to, proteins, peptides, genes, antibodies, anesthetics, insulins, vaccines, polysaccharides, synthetic organic compounds, synthetic inorganic compounds, or cosmetic ingredients such as whitening, filler, anti-wrinkle or antioxidants. can be The active material may be dispersed in a solvent that forms the microneedles 110 in the form of fine particles, may be uniformly dissolved in the solvent, or may be coated on the microneedles 110 . This is not a non-limiting example, and the present invention is not limited, and the active material may be included in the plurality of microneedles 110 in various ways.

In another embodiment, a keratolytic material may be coated on the plurality of microneedles 110 . The keratolytic material may include glycolic acid, lactic acid, malic acid, citric acid, tartaric acid, salicylic acid, gluconic acid, galactose, or a combination thereof. The combination of the keratolytic substances may be variously combined according to the oil-water ratio of the skin, and various known techniques may be referred to. According to an embodiment of the present invention, since the keratolytic material decomposes the hard stratum corneum on the outermost surface of the skin, it is possible to prevent the microneedles 110 from collided with the stratum corneum and damaged during the insertion into the skin.

Referring back to FIG. 1A , the water-soluble base layer 120 of the microneedle patch 100 is removed by being decomposed by the moisture when moisture is supplied, thereby individualizing the plurality of microneedles 110 supported by it. have. In one embodiment, the water-soluble base layer 120 may be formed of a water-soluble material that absorbs moisture and decomposes or dissolves. The water-soluble material may include agar, gelatin, carrageenan, polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polyacrylic acid, polyacrylate, or a combination thereof. This is a non-limiting example, and various types of water-soluble substances may be applied. When the microneedles 110 are made of a water-soluble material, the water-soluble base layer 120 may be formed of a different water-soluble material that is the same as or different from the water-soluble material of the microneedles 110 . Preferably, the water-soluble material of the water-soluble base layer 120 is different from the water-soluble material of the microneedles 110 . In this case, the decomposition or dissolution rate of the water-soluble base layer 120 with respect to moisture may be greater than the decomposition or dissolution rate of the microneedles 110 .

2 is a view showing a method of operation of the microneedle patch 100 according to an embodiment of the present invention.

Referring to FIG. 2 , in one embodiment, when the microneedle patch 100 is applied to the skin, moisture (wt) is supplied to the water-soluble base layer 120 and decomposed by the water (wt), thereby the water-soluble base layer 120. When this is removed, a plurality of two-dimensionally arranged micro-needles 110 may be individualized from each other. The figure above the arrow shows immediately after the microneedle patch 100 is exemplarily attached to a biological surface, such as the skin 20, and the figure below the arrow shows that the microneedle patch 100 is supplied with moisture (wt). It shows that the water-soluble base layer 120 is decomposed and removed, and the individualized microneedles 110 are maintained in a state inserted into the skin 20, respectively.

In one embodiment, the microneedles 110 are biodegradable or dissolve or decompose the water-soluble basal layer 120 after being maintained for a predetermined time in a state that penetrates the epidermis or the epidermis of the skin 20 to the upper part of the dermis. It can be weakened and decomposed by moisture (wt) for After the microneedles 110 are inserted, the active material contained in the microneedles 110 may be released for the predetermined time.

In one embodiment, for supply of moisture (wt), after attaching the microneedle patch 100 to the skin 20, a water-soluble base layer ( 120) can be decomposed and removed. For a detailed description of the moisture supply member, reference may be made to the disclosure regarding the microneedle system 10 of FIG. 4 . In another embodiment, after attaching the microneedle patch 100 to the skin 20, washing face or using a tool such as a spray may provide moisture (wt). A detailed description of the moisture supply member will be described later in order to avoid overlapping descriptions. According to an embodiment of the present invention, by omitting the process of removing the microneedle patch 100 after using it, it is possible to obtain a fairly high level of cosmetic effect in a short time. In addition, since the water-soluble basal layer 120 is removed in the course of use, there is no problem of detachment from the biological surface due to the movement of the basal layer itself according to the movement of the curved biological surface or the muscle of the biological surface, and the microneedle ( 110) is stably maintained in the body surface, and effective substances are delivered, thereby maximizing the medical, pharmaceutical, or cosmetic effect of the microneedle patch 100 .

Referring back to FIG. 1A , the first surface 120S1 of the water-soluble base layer 120 on which the microneedles 110 are formed may have adhesiveness. The strength of the adhesive is not limited to a specific strength, and when the water-soluble base layer 120 comes into contact with the contact surface such as the skin 20 and adheres without falling off, it may be defined as having adhesiveness. According to an embodiment of the present invention, after attaching the microneedle patch 100 to the skin 20, the attached state can be maintained even without separately fixing the microneedle patch 100, so that the skin before supplying moisture (wt) It can be prevented from being easily detached from (20). Therefore, when using the micro-needle patch 100, other activities are possible while the micro-needle patch 100 is attached, and there is an advantage in that the convenience of use is improved.

Figures 3a to 3c is a view showing a microneedle patch 100 according to various embodiments of the present invention.

Referring to FIG. 3A , in one embodiment, the water-soluble base layer 120 is bonded to the base part 111 while passing the base part 111 of the microneedles 110 adjacent to each other among the plurality of microneedles 110 . It may be a mesh structure including a plurality of linear parts 121 that are formed. The linear portions 121 may cross each other in at least some regions to form the base layer 120 having a planar structure. In one embodiment, the linear parts 121 may be a fibrous structure formed by processing the precursor of the base layer 120 . For example, at least any part of the linear part 121 may be a linear structure, the other part may be a curved structure having a predetermined curvature, or a combination of a linear structure having at least any one or more bent portions.

Referring to FIG. 3B , in one embodiment, the water-soluble base layer 120 may be a through-hole structure. For example, the water-soluble base layer 120 may include a plurality of through pores (h), and the plurality of pores (h) are a moisture supply member for supplying moisture to the microneedle patch 100 ( FIG. 4 ). 200) may act as a movement path for the substances included in the skin. The plurality of through voids h may have a polygonal or oval shape such as a circle, a triangle, or a square.

In another embodiment, the through void h may have a slit-shaped straight line, a meander pattern, or a wavy pattern and a linear structure, or a complex pattern in which these patterns intersect each other. When the water-soluble base layer 120 is deformed due to flexibility or elasticity, the size or shape of the through-pore h may be changed. The area occupied by the plurality of through-pores h relative to the total area of the water-soluble base layer 120 may be in the range of 10% to 80%. As the area occupied by the plurality of through-pores h increases, elasticity or flexibility of the water-soluble base layer 120 may be improved. According to an embodiment of the present invention, a plurality of through-pores (h) 0 are formed in the water-soluble base layer 120 , so that the total amount of the water-soluble base layer 120 is compared to the case without the plurality of through-pores (h). Since the amount of water absorbed by the water-soluble base layer 120 formed of a water-soluble material is small due to the small volume or area in which the solid is autonomous relative to the area, the adverse effect of absorbing moisture from the skin can be minimized.

Referring to FIG. 3C , in one embodiment, the water-soluble base layer 120 may have a nonwoven structure. The plurality of linear portions 121 constituting the water-soluble base layer 120 may be intersected and fixed to form a nonwoven fabric structure in which the linear portions 121 are randomly disposed without forming a fabric. According to an embodiment of the present invention, the random arrangement of the linear parts 121 is possible, thereby improving the production speed of the water-soluble base layer 120 and increasing the production yield of the microneedle patch 100 .

4 is a view showing a microneedle system 10 according to an embodiment of the present invention.

Referring to FIG. 4 , in one embodiment, the microneedle system 10 is individualized with each other, and a plurality of microneedles 110 having an upper end 112 and a base 111 , a plurality of microneedles 110 . By removing the water-soluble base layer 120 by supplying moisture to the water-soluble base layer 120 and the water-soluble base layer 120 that are bonded to and arrange the plurality of microneedles 110 two-dimensionally, the two-dimensionally arranged A moisture supply member 200 for individualizing the plurality of microneedles 110 may be included. For detailed descriptions of the plurality of microneedles 110 and the water-soluble base layer 120 , reference may be made to the foregoing disclosures in FIGS. 1A to 3C without inconsistency.

In one embodiment, the moisture supply member 200 may be a carrier for supporting a material containing a large amount of moisture or moisture, such as a moisture-containing sheet, a hydrogel sheet, or a mask pack. For example, the carrier may be a non-woven fabric as a non-limiting example. The carrier may include any form capable of storing and discharging moisture. In another embodiment, the moisture supply member 200 does not include a separate carrier, and moisture gel, moisture cream, skin, essence, toner, or a combination thereof may be directly applied on the microneedle patch 100 . .

In another embodiment, the moisture supply member 200 may be a natural moisture carrier. The natural moisture carrier may be a natural pack using natural materials such as cucumber, potato, yogurt or rice water. The above-described examples are non-limiting examples, and all kinds of materials containing moisture may be applied.

In one embodiment, the moisture supply member 200 may include a pharmaceutical, medical, or cosmetically active substance. The moisture supply member 200 may include the same type of active material as the plurality of microneedles 110 or may include different types of active material. For a detailed description of the active material, reference may be made to the above-described disclosure regarding the active material included in the plurality of microneedles 110 . The microneedles 110 are decomposed inside the skin after penetrating the epidermal layer or the upper layers of the epidermis and dermis of the skin, thereby forming a material exchange channel between the skin and the moisture supply member 200 so that the active substances are to easily penetrate into the skin. According to an embodiment of the present invention, unlike the case in which the active substances are simply provided to the skin by penetrating the active substances into the skin through the substance exchange channel, an efficient effective substance transfer effect can be obtained.

In one embodiment, the water-soluble base layer 120 may include a material that absorbs heat when dissolved. The material may include a compound having a negative (-) heat of dissolution. For example, it may be ammonium nitrate, sodium chloride, potassium chloride, xylitol, barium hydroxide, barium oxide, potassium magnesium sulfate, potassium aluminum sulfate, sodium borate, sodium phosphate, or a combination thereof. According to an embodiment of the present invention, the water-soluble base layer 120 can provide a cooling or refreshing feeling to the skin by absorbing the heat of dissolution while the water-soluble base layer 120 is dissolved by moisture, including substances having negative heat of dissolution, By lowering the temperature of the skin, it can calm the skin irritated by the hot weather, and has the effect of suppressing the secretion of sebum.

In one embodiment, the microneedle system 10 may be configured in a predetermined package (not shown), and the package includes a first receiving area (not shown) in which the microneedle patch 100 is accommodated and a moisture supply member ( 200) is accommodated, and may include a second accommodating area (not shown) isolated from the first accommodating area. The package can prevent the water-soluble base layer 120 from absorbing moisture and decomposing before use by isolating the microneedle patch 100 and the moisture supply member 200 .

In an embodiment, the first accommodating area and/or the second accommodating area may be a space separated by an isolation member within a single pouch or packaging material. The isolation member may be, for example, a synthetic resin film. In another embodiment, the first receiving area may be provided by a first supporting film member, and the second receiving area may be provided by a second supporting film member. The first support film member and/or the second support film member include an upper support member and a lower support member, and the microneedle patch 100 and/or the moisture supply member 200 are disposed between the upper support member and the lower support member. ) can be placed and sealed.

5 is a view showing an application method of the micro-needle system 10 according to an embodiment.

Referring to FIG. 5, in one embodiment, first, the microneedle patch 100 is attached ( k1) can be Thereafter, the moisture supply member 200 may be disposed (k2) on the second surface (S2) opposite to the first surface (S1) after a predetermined time elapses or immediately after. In one embodiment, a film for moving the microneedle patch 100 onto the skin may be provided on the second surface S2 of the microneedle patch 100, and the user uses the film to the microneedle patch ( 100) may be attached to the first surface (S1) on the skin (k1), and the film may be removed. This is a non-limiting example, and the embodiment of the present invention is not limited to the above-described embodiment, and various known techniques may be referred to.

In one embodiment, before attaching (k1) the microneedle patch 100 on the skin 20, a predetermined active substance is provided on the first surface S1 of the microneedle patch 100, and the active substance The provided microneedle patch 100 may be attached to the skin 20 (k1). Alternatively, before attaching (k1) the microneedle patch 100, the predetermined active material is provided on the skin 20, and the microneedle patch 100 is applied on the skin 20 provided with the predetermined active material. Can be attached (k1). According to the embodiment of the present invention, a predetermined active material is provided in the area between the skin 20 and the microneedle patch 100, so that the upper end 112 of the microneedle 110 is formed when the microneedle patch 100 is attached. As it is injected into the skin 20, the active material may have a physical action to move into the skin 20, and since the microneedle 110 may form a movement path of the active material, the active material may be efficiently transferred to the skin 20 ) can penetrate into the inside, thereby maximizing the effect of the active substance. In addition, the active material is not provided included in the microneedle patch 100, but ingredients such as lotions, creams, gels, natural packs, or vitamins used by the user can be applied, so it is easy to use, and various active substances It has the advantage that the usable range is wide as they can be applied.

In one embodiment, the method of manufacturing the microneedle system 10 is individualized with each other, and preparing the microneedles 110 having a plurality of microneedles 110 having an upper end 112 and a base 111 . Step, bonding with the plurality of microneedles 110, forming the base layer 120 of a planar structure formed of a water-soluble material, and providing a moisture supply member 200 for supplying moisture to the base layer 120 may include steps.

It is common in the art to which the present invention pertains that the present invention described above is not limited to the above-described embodiments and the accompanying drawings, and various substitutions, modifications and changes are possible within the scope without departing from the technical spirit of the present invention. It will be clear to those who have knowledge.

100: micro needle patch
110: micro needle
120: water-soluble basal layer
111: base
112: upper part
h: through void
wt: moisture
20: skin
200: absence of moisture supply
10: micro-needle system

Claims (10)

a plurality of microneedles singulated from each other and having an upper end and a base; and
A microneedle patch comprising a water-soluble base layer bonded to the plurality of microneedles to two-dimensionally arrange the plurality of microneedles,
When the microneedle patch is applied to the skin and the plurality of microneedles are inserted into the skin, moisture is supplied to the water-soluble base layer from the outside of the skin, whereby the water-soluble base layer is decomposed or dissolved, of microneedles are individualized within the skin,
The water-soluble base layer has a mesh structure formed by intersecting a plurality of linear parts, and the microneedles are disposed in a region where the plurality of linear parts intersect,
The decomposition or dissolution rate of the material of the water-soluble base layer with respect to water is faster than the decomposition or dissolution rate of the material of the microneedle against water,
The water-soluble base layer comprises a material that absorbs heat upon dissolution, and the heat-absorbing material is ammonium nitrate, sodium chloride, potassium chloride, barium hydroxide, barium oxide, potassium magnesium sulfate, potassium aluminum sulfate, sodium borate, sodium phosphate or A combination of these microneedle patches. The method of claim 1,
The plurality of microneedles is a microneedle patch formed of a biodegradable material. The method of claim 1,
A microneedle patch in which a keratolytic material is coated on the plurality of microneedles. delete delete a plurality of microneedles singulated from each other and having an upper end and a base;
a water-soluble base layer bonded to the plurality of micro-needles to two-dimensionally arrange the plurality of micro-needles; and
When the microneedle patch is applied to the skin and the plurality of microneedles are inserted into the skin, moisture is supplied to the water-soluble base layer from the outside of the skin to decompose or dissolve the water-soluble base layer, so that the two-dimensional A moisture supply member for individualizing a plurality of microneedles arranged in a manner within the skin,
The water-soluble base layer has a mesh structure formed by intersecting a plurality of linear parts, and the microneedles are disposed in a region where the plurality of linear parts intersect,
The decomposition or dissolution rate of the material of the water-soluble base layer with respect to water is faster than the decomposition or dissolution rate of the material of the microneedle against water,
The water-soluble base layer comprises a material that absorbs heat upon dissolution, and the heat-absorbing material is ammonium nitrate, sodium chloride, potassium chloride, barium hydroxide, barium oxide, potassium magnesium sulfate, potassium aluminum sulfate, sodium borate, sodium phosphate or A microneedle system that is a combination of these. 7. The method of claim 6,
The water-soluble base layer is a microneedle system including a plurality of through-pores that act as a movement path for the substances included in the moisture supply member to move to the skin. 7. The method of claim 6,
The moisture supply member is a moisture-containing sheet, a hydrogel sheet, a mask pack, a moisture gel, a moisture cream, a skin, an essence, a toner, or a combination thereof. 7. The method of claim 6,
The moisture supply member is
A microneedle system comprising a pharmaceutical, medical or cosmetically active substance. 7. The method of claim 6,
The microneedle system is decomposed inside the skin and penetrates a part of the skin to form a material exchange channel between the skin and the moisture supply member.

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